CLI
MCID: CRT049
MIFTS: 60

Critical Limb Ischemia (CLI) malady

Summaries for Critical Limb Ischemia

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32MalaCards
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MalaCards: Critical Limb Ischemia, also known as CLI, is related to ischemia and peripheral vascular disease. An important gene associated with Critical Limb Ischemia is APOM (apolipoprotein M), and among its related pathways are Malaria and Tyrosine Kinases / Adaptors. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Critical Limb Ischemia

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30LifeMap Discovery™, 44Novoseek, 60UMLS
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Aliases & Descriptions:

critical limb ischemia 30 44 60
cli 30 44


Related Diseases for Critical Limb Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Critical Limb Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia32.2SELE, TEK, PGF, FGF2, FGF1, FGF4
2peripheral vascular disease30.8SELE, VWF, APOA1
3intermittent claudication30.7VWF, FGF2
4diabetes mellitus30.7APOA1, EDN1, ANGPT2, SELE, TEK, THBD
5vascular disease30.5APOA1, APOH, EDN1, ANGPT2, FGF2, VWF
6hyperhomocysteinemia30.4SELE, THBD, VWF, APOH
7uremia30.2VWF
8systemic scleroderma30.2EDN1
9hypertension30.2SELE, PGF, EDN1, APOA1
10coronary artery disease30.1APOA1, SELE, TEK, THBD, VWF, PGF
11atherosclerosis30.1APOA1, APOM, SELE, TEK, THBD, THBS1
12colorectal cancer29.9HGF, ANGPT2, CD40, PGF, THBS1, TEK
13lung cancer29.9HGF, ANGPT2, CD40, AXL, THBS1, TEK
14breast cancer29.9HGF, ANGPT2, NGFR, AXL, FGF4, FGF1
15diabetic foot ulcers10.4
16thromboangiitis obliterans10.3
17spinal cord ischemia10.3
18ischemic neuropathy10.1
19pyoderma gangrenosum10.1
20thoracic aortic aneurysm10.1
21aortic aneurysm10.1
22brain disease10.1
23neuropathy10.1
24pyoderma10.1
25scleroderma10.1
26hepatitis10.0HGF
27multiple myeloma10.0CD40
28hyperthyroidism10.0CD40
29myeloid leukemia10.0AXL
30leiomyoma10.0FGF1
31pneumonia10.0CD40
32nephritis10.0APOH
33eclampsia10.0THBD
34disseminated intravascular coagulation10.0THBD
35hemangiopericytoma10.0NGFR
36kawasaki disease10.0SELE
37myelodysplastic syndromes10.0FGF1
38arteriosclerosis obliterans10.0HGF
39biliary atresia10.0HGF
40meningioma10.0PGF
41hyperglycemia10.0SELE
42goiter10.0TEK
43hepatitis b10.0APOA1
44nephrotic syndrome10.0APOA1
45wilms tumor10.0THBS1
46migraine10.0APOH
47glomerulonephritis10.0AXL, GAS6
48deficiency anemia10.0VWF
49hepatopulmonary syndrome10.0EDN1
50cor pulmonale10.0EDN1

Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to critical limb ischemia

Clinical Features for Critical Limb Ischemia

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Drugs & Therapeutics for Critical Limb Ischemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Critical Limb Ischemia

Drug clinical trials:

Search ClinicalTrials for Critical Limb Ischemia

Search NIH Clinical Center for Critical Limb Ischemia

Search CenterWatch for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous angiogenic cell precursors for the treatment of critical limb ischemia
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 9020076, 23192920, 22163120
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells, PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMID: 21216483
Bone marrow-derived mesenchymal stem cells , PMID: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells , PMIDs: 18005405, 18713449, 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T), PMIDs: 22453769, 22776246, 21684715
Bone marrow-derived mononuclear cells, PMID: 21586448
Bone marrow-derived mesenchymal stem cells, PMID: 21586448
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19526389, 19478280
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMIDs: 23307180, 18720444, 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

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Anatomical Context for Critical Limb Ischemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Critical Limb Ischemia:

32
Bone, Bone marrow, Endothelial, Monocytes, Spinal cord, Skin, Brain

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Critical Limb Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Critical Limb Ischemia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2ANGPT2
2MP:00036319.8FGF1, AXL, NGFR, EDN1
3MP:00053919.5ANGPT2, NGFR, AXL, FGF2, THBS1, SELE
4MP:00053709.2HGF, APOA1, NGFR, AXL, THBS1, THBD
5MP:00028738.7EDN1, NGFR, CD40, AXL, FGF4, FGF1
6MP:00053858.6EDN1, GAS6, APOA1, HGF, ANGPT2, NGFR
7MP:00053878.5APOA1, GAS6, ANGPT2, NGFR, CD40, AXL
8MP:00053768.5SELE, APOA1, APOM, APOH, GAS6, NGFR
9MP:00053848.4HGF, APOA1, GAS6, NGFR, CD40, AXL
10MP:00053978.3CD40, NGFR, GAS6, APOA1, HGF, AXL
11MP:00107688.0NGFR, ANGPT2, EDN1, GAS6, APOH, HGF

Publications for Critical Limb Ischemia

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50PubMed
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Articles related to Critical Limb Ischemia:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Endovascular recanalization of infrapopliteal occlusions in patients with critical limb ischemia. (24393279)
2014
2
Randomized controlled trial of dual antiplatelet therapy in patients undergoing surgery for critical limb ischemia. (21694576)
2014
3
Endovascular-first approach is not associated with worse amputation-free survival in appropriately selected patients with critical limb ischemia. (24184092)
2014
4
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
5
Transplantation of purified CD34+ cells in the treatment of critical limb ischemia. (23611711)
2013
6
Risk prediction of 30-day readmission after infrainguinal bypass for critical limb ischemia. (23395204)
2013
7
'Real Angiosome' Assessment from Peripheral Tissue Perfusion Using Tissue Oxygen Saturation Foot-mapping in Patients with Critical Limb Ischemia. (24412085)
2013
8
Critical limb ischemia: an update for interventional radiologists. (23233402)
2013
9
Critical limb ischemia in a young man: saddle embolism or unusual presentation of thromboangiitis obliterans? (24367737)
2013
10
Drug-eluting balloon in peripheral intervention for below the knee angioplasty evaluation (DEBATE-BTK): a randomized trial in diabetic patients with critical limb ischemia. (23797811)
2013
11
Comparison of clinical outcome of infrapopliteal angioplasty between Korean diabetic and non-diabetic patients with critical limb ischemia. (22112858)
2012
12
Critical limb ischemia: advanced medical therapy. (23342181)
2012
13
Factors affecting amputation-free survival rates in critical limb ischemia. (22357163)
2012
14
Regenerative medicine in critical limb ischemia. (22785564)
2012
15
Autologous bone marrow stem cell transplantation in critical limb ischemia: a meta-analysis of randomized controlled trials. (23217403)
2012
16
Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats. (21926605)
2012
17
A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia. (23192920)
2012
18
The effectiveness of skin perfusion pressure measurements during endovascular therapy in determining the endpoint in critical limb ischemia. (22728485)
2012
19
Retrograde transpedal stenting of the tibioperoneal trunk in critical limb ischemia. (22121120)
2012
20
A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study. (23197862)
2012
21
MRI tracking of transplanted iron-labeled mesenchymal stromal cells in an immune-compromised mouse model of critical limb ischemia. (23165968)
2012
22
Postoperative treatment of critical limb ischemia. (22520633)
2012
23
Variation in the use of lower extremity vascular procedures for critical limb ischemia. (22147886)
2012
24
Socioeconomic and hospital-related predictors of amputation for critical limb ischemia. (21163610)
2011
25
Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia. (22289660)
2011
26
A multicenter comparison between autologous saphenous vein and heparin-bonded expanded polytetrafluoroethylene (ePTFE) graft in the treatment of critical limb ischemia in diabetics. (21840151)
2011
27
Early and Long-term Effects of the Autologous Peripheral Stem Cell Implantation for Critical Limb Ischemia. (23555471)
2011
28
Early results and lessons learned from a multicenter, randomized, double-blind trial of bone marrow aspirate concentrate in critical limb ischemia. (22019148)
2011
29
Superiority of transcutaneous oxygen tension measurements in predicting limb salvage after below-the-knee angioplasty: a prospective trial in diabetic patients with critical limb ischemia. (20820781)
2011
30
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
31
Think of the angiosome concept when revascularizing the patient with critical limb ischemia. (20432387)
2010
32
Dynamic skin perfusion pressure: a new measure of assessment for wound healing capacity and alternative angiosome in critical limb ischemia. (20885234)
2010
33
Perioperative platelet and monocyte activation in patients with critical limb ischemia. (20816321)
2010
34
An elevated neutrophil-lymphocyte ratio independently predicts mortality in chronic critical limb ischemia. (20573475)
2010
35
Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia. (19747609)
2009
36
Value of MDCT angiography in developing treatment strategies for critical limb ischemia. (19380571)
2009
37
Update on PADI trial: percutaneous transluminal angioplasty and drug-eluting stents for infrapopliteal lesions in critical limb ischemia. (19700099)
2009
38
Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients. (19563958)
2009
39
Long-term outcomes after medical and interventional therapy of critical limb ischemia. (19782924)
2009
40
Subintimal angioplasty for below-the-ankle arterial occlusions in diabetic patients with chronic critical limb ischemia. (19842730)
2009
41
New techniques for endovascular treatment of peripheral artery disease with focus on chronic critical limb ischemia. (19229799)
2009
42
The efficacy and safety of closure of brachial access using the AngioSeal closure device: experience with 161 interventions in diabetic patients with critical limb ischemia. (18295438)
2008
43
Meta-analysis of infrapopliteal angioplasty for chronic critical limb ischemia. (18372148)
2008
44
Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? (18713449)
2008
45
Angiogenesis achieved by granulocyte colony-stimulating factor in combination with bypass surgery in 2 cases of critical limb ischemia. (18654031)
2008
46
The prostacyclin analogue iloprost increases circulating endothelial progenitor cells in patients with critical limb ischemia. (18989532)
2008
47
A comparison of percutaneous transluminal angioplasty versus amputation for critical limb ischemia in patients unsuitable for open surgery. (17264008)
2007
48
Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia. (17598820)
2007
49
Risk factors for development of critical limb ischemia -- a survey of diabetic vs. nondiabetic population. (17211294)
2006
50
Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia? (17164743)
2006

Genetic Variations for Critical Limb Ischemia

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Expression for genes affiliated with Critical Limb Ischemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for genes affiliated with Critical Limb Ischemia

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Sources:
29KEGG, 4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD40
210.2FGF1, AXL
310.1FGF2, FGF1
4
Hide members
9.8FGF2, FGF1, FGF4
59.8FGF4, FGF1, FGF2
6
Hide members
9.8C4BPB, VWF, THBD
79.7TEK, FGF2, FGF1, ANGPT2
8
Hide members
9.7HGF, GAS6, NGFR, PGF
9
Hide members
9.7NGFR, FGF4, FGF1, FGF2
10
Hide members
9.6GAS6, AXL, FGF4, PGF
11
Hide members
9.6THBS1, VWF, PGF, HGF
129.6GAS6, ANGPT2, THBD, TEK, SELE
13
Hide members
9.5HGF, APOA1, GAS6, VWF, THBS1
14
Hide members
9.5NGFR, FGF4, FGF1, FGF2, THBS1
15
Hide members
9.5HGF, ANGPT2, NGFR, CD40, AXL, TEK
169.5HGF, FGF4, FGF1, FGF2, THBS1
17
Hide members
9.5HGF, FGF4, FGF1, FGF2, THBS1
18
Hide members
9.5VWF, THBS1, THBD, TEK, SELE
19
Hide members
9.3C4BPB, CD40, FGF4, FGF1, FGF2, HGF
20
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
21
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
22
Hide members
8.9HGF, GAS6, ANGPT2, NGFR, FGF4, FGF1
23
Hide members
8.9HGF, GAS6, AXL, FGF4, FGF1, FGF2
24
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
25
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
26
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
27
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
28
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
29
Hide members
8.6NGFR, ANGPT2, GAS6, HGF, AXL, FGF4
30
Hide members
8.6APOA1, EDN1, NGFR, FGF4, FGF1, FGF2
318.5TEK, HGF, ANGPT2, NGFR, FGF4, FGF1

Compounds for genes affiliated with Critical Limb Ischemia

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7APOH
2cycloheximide4410.5HGF
3dexamethasone44 49 28 1113.2HGF, ANGPT2, FGF1, FGF2
4phosphatidylserine44 28 1112.2AXL, C4BPB, GAS6, APOH
5kininogen4410.1THBS1, VWF, APOH
6Pentosan Polysulfate1110.0FGF4, FGF1, FGF2
7warfarin44 49 11 2413.0APOH, GAS6, AXL, FGF2, VWF
86-ketoprostaglandin f1alpha4410.0THBD, VWF, EDN1, APOH
9creatinine449.9APOA1, APOH, ANGPT2, THBD, SELE
10dermatan sulfate449.9HGF, FGF1, FGF2, VWF, THBD
11txb2449.8APOH, EDN1, VWF, THBS1, THBD
12cyclosporin a44 28 5911.8EDN1, ANGPT2, CD40, FGF2, THBS1, THBD
13fluvastatin44 49 28 1112.8APOA1, CD40, VWF, THBD, SELE
14dextran sulfate449.7HGF, APOA1, APOH, FGF1, THBS1, SELE
15prednisolone44 28 1111.7HGF, APOH, CD40, FGF2, VWF, THBD
16heparin44 28 11 2412.7APOH, C4BPB, FGF4, PGF, SELE
17infliximab44 49 1111.7APOA1, APOH, ANGPT2, FGF2, TEK, SELE
18serine449.7C4BPB, FGF1, FGF2, THBS1, TEK, SELE
19N,O6-Disulfo-Glucosamine119.7FGF2, FGF1, HGF
20pge1449.6HGF, APOH, CD40, VWF, THBD
21hyaluronic acid44 2410.6HGF, CD40, FGF1, FGF2, VWF, THBS1
22losartan44 49 28 1112.6HGF, EDN1, VWF, THBD, SELE
23heparan sulfate44 2410.6HGF, FGF4, FGF1, FGF2, THBS1, THBD
24cyclophosphamide44 49 1111.6HGF, APOH, CD40, VWF, THBS1, THBD
25ly294002449.5HGF, GAS6, ANGPT2, CD40, AXL, FGF2
26wortmannin449.5HGF, GAS6, ANGPT2, NGFR, CD40, AXL
27matrigel449.4THBS1, PGF, FGF1, FGF4, NGFR, TEK
28histamine44 28 2411.4HGF, EDN1, NGFR, CD40, VWF, THBD
29phospholipid449.4APOA1, APOM, APOH, C4BPB, CD40, VWF
30actinomycin d449.4HGF, EDN1, CD40, FGF1, FGF2, THBD
31oxygen44 2410.4HGF, ANGPT2, NGFR, CD40, FGF4, FGF1
32genistein44 28 59 2 11 2414.3HGF, APOA1, EDN1, CD40, FGF1, FGF2
33fibrinogen449.3APOA1, APOH, ANGPT2, CD40, VWF, THBS1
34thymidine44 2410.3HGF, EDN1, ANGPT2, NGFR, CD40, FGF1
35aspirin44 49 28 2412.3HGF, APOA1, APOH, VWF, THBD, SELE
36agar449.3HGF, NGFR, FGF4, FGF1, FGF2, THBS1
37atorvastatin44 49 28 11 2413.2APOA1, EDN1, CD40, PGF, VWF, THBS1
38glucose449.2APOA1, APOM, APOH, ANGPT2, NGFR, CD40
39h2o2449.2HGF, APOA1, ANGPT2, CD40, FGF1, FGF2
40lactate449.1APOA1, APOH, FGF1, VWF, THBD, SELE
41paraffin448.9TEK, THBD, THBS1, VWF, PGF, FGF2
42alanine448.9HGF, APOA1, C4BPB, FGF1, FGF2, VWF
43cholesterol44 28 11 2411.8APOA1, APOM, APOH, NGFR, CD40, FGF4
44retinoic acid44 249.8HGF, APOA1, ANGPT2, NGFR, CD40, FGF4
45lipid448.8HGF, APOA1, APOM, APOH, NGFR, CD40
46prostacyclin448.7HGF, SELE, THBD, THBS1, VWF, PGF
47phosphatidylinositol448.6HGF, APOH, TEK, THBS1, PGF, FGF2
48nitric oxide44 11 2410.6CD40, NGFR, ANGPT2, EDN1, APOH, FGF1
49tyrosine448.3AXL, CD40, NGFR, ANGPT2, GAS6, HGF
50vegf447.9SELE, TEK, THBD, THBS1, VWF, PGF

GO Terms for genes affiliated with Critical Limb Ischemia

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Sources:
16Gene Ontology
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Cellular components related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.1THBS1, VWF
2very-low-density lipoprotein particleGO:0343619.9APOH, APOM, APOA1
3platelet alpha granule lumenGO:0310939.9HGF, GAS6, VWF, THBS1
4high-density lipoprotein particleGO:0343649.8APOA1, APOM, APOH
5spherical high-density lipoprotein particleGO:0343669.8APOM, APOA1
6cell surfaceGO:0099869.5APOH, NGFR, AXL, THBS1, THBD, TEK
7extracellular spaceGO:0056158.4HGF, APOA1, APOH, GAS6, EDN1, ANGPT2
8extracellular regionGO:0055767.7TEK, HGF, APOA1, GAS6, C4BPB, EDN1

Biological processes related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dendritic cell apoptotic processGO:200066910.6GAS6, AXL
2positive regulation of cytokine-mediated signaling pathwayGO:00196110.5GAS6, AXL
3cellular response to interferon-alphaGO:03545710.5AXL, GAS6
4Tie signaling pathwayGO:04801410.5ANGPT2, TEK
5dendritic cell differentiationGO:09702810.5GAS6, AXL
6high-density lipoprotein particle assemblyGO:03438010.5APOA1, APOM
7positive regulation of natural killer cell differentiationGO:03282510.5GAS6, AXL
8high-density lipoprotein particle clearanceGO:03438410.5APOA1, APOM
9negative regulation of smooth muscle cell apoptotic processGO:03439210.5APOH, EDN1
10enzyme linked receptor protein signaling pathwayGO:00716710.5GAS6, AXL
11positive regulation of endothelial cell apoptotic processGO:200035310.5CD40, THBS1
12negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.4APOA1, GAS6
13positive regulation of intracellular protein kinase cascadeGO:01074010.4FGF1, TEK
14chondroblast differentiationGO:06059110.4FGF2, FGF4
15negative regulation of blood vessel endothelial cell migrationGO:04353710.4ANGPT2, FGF2, THBS1
16negative regulation of fibroblast growth factor receptor signaling pathwayGO:04003710.4THBS1, NGFR
17negative regulation of fibrinolysisGO:05191810.4THBD, THBS1, APOH
18response to glucose stimulusGO:00974910.4THBS1, ANGPT2, APOM
19apoptotic cell clearanceGO:04327710.3GAS6, AXL
20negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.3HGF, GAS6, THBS1
21cell-substrate adhesionGO:03158910.3VWF, GAS6
22negative regulation of blood coagulationGO:03019510.3APOH, EDN1, THBD
23positive regulation of blood coagulationGO:03019410.3APOH, THBS1
24positive regulation of endothelial cell migrationGO:01059510.3TEK, THBS1, EDN1
25positive regulation of protein kinase B signaling cascadeGO:05189710.2GAS6, AXL, THBS1, TEK
26sprouting angiogenesisGO:00204010.2TEK, THBS1, PGF
27positive regulation of protein phosphorylationGO:00193410.2FGF1, FGF4, CD40, GAS6
28negative regulation of endothelial cell apoptotic processGO:200035210.2GAS6, TEK
29negative regulation of angiogenesisGO:01652510.2APOH, ANGPT2, THBS1, TEK
30positive regulation of cell migrationGO:03033510.2HGF, EDN1, FGF1, THBS1
31positive regulation of endothelial cell proliferationGO:00193810.2TEK, PGF, FGF2
32high-density lipoprotein particle remodelingGO:03437510.1APOM, APOA1
33positive regulation of ERK1 and ERK2 cascadeGO:07037410.1GAS6, FGF4, FGF2, TEK
34activation of MAPK activityGO:00018710.1THBS1, FGF2, HGF
35response to hypoxiaGO:00166610.0EDN1, ANGPT2, PGF, THBS1
36endothelial cell proliferationGO:00193510.0APOA1, TEK
37leukocyte migrationGO:05090010.0GAS6, ANGPT2, THBD, TEK, SELE
38organ inductionGO:00175910.0FGF2, FGF1
39positive regulation of cell divisionGO:05178110.0PGF, FGF2, FGF1, FGF4
40platelet degranulationGO:00257610.0HGF, APOA1, GAS6, VWF, THBS1
41organ regenerationGO:03110010.0HGF, APOA1, GAS6, ANGPT2, PGF
42neurotrophin TRK receptor signaling pathwayGO:0480119.9FGF2, FGF1, FGF4, NGFR
43negative regulation of endothelial cell migrationGO:0105969.8THBS1, APOH
44negative regulation of apoptotic processGO:0430669.8HGF, GAS6, NGFR, FGF4, THBS1, TEK
45cell-cell signalingGO:0072679.8EDN1, FGF4, PGF, TEK
46positive regulation of angiogenesisGO:0457669.7ANGPT2, FGF1, FGF2, PGF, THBS1, TEK
47positive regulation of cell proliferationGO:0082849.7EDN1, FGF4, FGF1, FGF2, PGF
48platelet activationGO:0301689.7HGF, APOA1, GAS6, CD40, AXL, VWF
49signal transductionGO:0071659.3GAS6, ANGPT2, AXL, FGF4, FGF1, FGF2
50blood coagulationGO:0075969.0SELE, HGF, APOA1, GAS6, C4BPB, ANGPT2

Molecular functions related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylserine bindingGO:00178610.1THBS1, AXL, GAS6
2fibroblast growth factor receptor bindingGO:0051049.8FGF2, FGF1, FGF4
3glycoprotein bindingGO:0019489.8APOH, VWF, THBS1
4growth factor activityGO:0080839.5HGF, FGF4, FGF1, FGF2, PGF
5receptor activityGO:0048729.5TEK, THBD, CD40, NGFR
6identical protein bindingGO:0428029.5APOA1, APOH, VWF, THBS1, HGF
7heparin bindingGO:0082019.4THBS1, PGF, FGF2, FGF1, FGF4, APOH
8protein bindingGO:0055157.7NGFR, ANGPT2, EDN1, GAS6, APOH, APOA1

Products for genes affiliated with Critical Limb Ischemia

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Sources for Critical Limb Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet