Aliases & Classifications for Critical Limb Ischemia

MalaCards integrated aliases for Critical Limb Ischemia:

Name: Critical Limb Ischemia 37 51 69
Cli 51

External Ids:

UMLS 69 C1142264

Summaries for Critical Limb Ischemia

MalaCards based summary : Critical Limb Ischemia, also known as cli, is related to peripheral artery disease and intermittent claudication. An important gene associated with Critical Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Aspirin and Menthol have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 72 Critical limb ischemia (CLI), also referred to as limb threat, is an advanced stage of peripheral artery... more...

Related Diseases for Critical Limb Ischemia

Diseases related to Critical Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 31.0 IL6 VEGFA
2 intermittent claudication 30.7 IL6 VEGFA
3 arteries, anomalies of 30.5 IL6 TNF VEGFA
4 diabetes mellitus 29.9 IL6 TNF VEGFA
5 limb ischemia 29.5 ANGPT2 HGF IL6 TEK TNF VEGFA
6 ischemia 11.1
7 endotheliitis 10.4
8 spinal disease 10.4 IL6 VEGFA
9 primary effusion lymphoma 10.3 IL6 VEGFA
10 macular retinal edema 10.3 IL6 VEGFA
11 central retinal vein occlusion 10.3 IL6 VEGFA
12 wrinkles 10.3 HGF VEGFA
13 capillary hemangioma 10.3 TEK VEGFA
14 retinal vein occlusion 10.3 IL6 VEGFA
15 pericardial effusion 10.3 IL6 VEGFA
16 arteriovenous malformation 10.3 IL6 VEGFA
17 intussusception 10.3 IL6 TEK
18 breast carcinoma in situ 10.3 IL6 VEGFA
19 arteriosclerosis obliterans 10.2 HGF IL6
20 radiation proctitis 10.2 TNF VEGFA
21 soft tissue sarcoma 10.2 TNF VEGFA
22 lymphangiosarcoma 10.2 TNF VEGFA
23 corneal neovascularization 10.2 TEK VEGFA
24 tuberculous meningitis 10.2 TNF VEGFA
25 scorpion envenomation 10.2 IL6 TNF
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
27 streptococcal toxic-shock syndrome 10.2 IL6 TNF
28 null-cell leukemia 10.2 IL6 TNF
29 retinitis pigmentosa 55 10.2 IL6 TNF
30 geographic tongue 10.2 TNF VEGFA
31 glossitis 10.2 IL6 TNF
32 laryngitis 10.2 IL6 TNF
33 anterior uveitis 10.2 IL6 TNF
34 acute vascular insufficiency of intestine 10.2 IL6 TNF
35 posterior urethral valves 10.2 IL6 TNF
36 retinal ischemia 10.2 TNF VEGFA
37 microscopic colitis 10.2 IL6 TNF
38 meconium aspiration syndrome 10.2 IL6 TNF
39 burning mouth syndrome 10.2 IL6 TNF
40 central nervous system vasculitis 10.2 IL6 TNF
41 osteosclerotic myeloma 10.2 IL6 TNF
42 stachybotrys chartarum 10.2 IL6 TNF
43 louse-borne relapsing fever 10.2 IL6 TNF
44 listeriosis 10.2 IL6 TNF
45 crimean-congo hemorrhagic fever 10.2 IL6 TNF
46 transverse myelitis 10.2 IL6 TNF
47 ischemic heart disease 10.2 IL6 TNF
48 intermediate uveitis 10.2 IL6 TNF
49 monoclonal gammopathy of uncertain significance 10.2 IL6 TNF
50 post-transplant lymphoproliferative disease 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to Critical Limb Ischemia

Symptoms & Phenotypes for Critical Limb Ischemia

MGI Mouse Phenotypes related to Critical Limb Ischemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 ANGPT2 HGF IL6 TEK TNF VEGFA
2 mortality/aging MP:0010768 9.43 VEGFA ANGPT2 HGF IL6 TEK TNF
3 vision/eye MP:0005391 9.02 VEGFA ANGPT2 IL6 TEK TNF

Drugs & Therapeutics for Critical Limb Ischemia

Drugs for Critical Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
2
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
3
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
4
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
5
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1 120202-66-6, 113665-84-2 60606
6
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
7
Cilostazol Approved, Investigational Phase 4,Phase 2 73963-72-1 2754
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
9
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
10
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
11 Analgesics Phase 4,Phase 2
12 Analgesics, Non-Narcotic Phase 4,Phase 2
13 Anti-Inflammatory Agents Phase 4,Phase 2
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
15 Antipyretics Phase 4,Phase 2
16 Antirheumatic Agents Phase 4,Phase 2
17 Cyclooxygenase Inhibitors Phase 4,Phase 2
18 Fibrinolytic Agents Phase 4,Phase 2
19 Peripheral Nervous System Agents Phase 4,Phase 2
20 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
21 Anti-Anxiety Agents Phase 4
22 Anticonvulsants Phase 4
23 calcium channel blockers Phase 4
24 Calcium, Dietary Phase 4,Early Phase 1
25 Central Nervous System Depressants Phase 4
26 Psychotropic Drugs Phase 4
27 Tranquilizing Agents Phase 4
28 Anticoagulants Phase 4,Phase 2,Early Phase 1
29 Antimetabolites Phase 4
30 Blood Substitutes Phase 4,Phase 2
31 Glucuronyl glucosamine glycan sulfate Phase 4
32 Hypoglycemic Agents Phase 4
33 Hypolipidemic Agents Phase 4
34 Lipid Regulating Agents Phase 4
35 Albumin-Bound Paclitaxel Phase 4,Phase 2,Phase 3
36 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
37 Antihypertensive Agents Phase 4,Phase 2,Phase 3
38 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
39 Purinergic P2 Receptor Antagonists Phase 4,Phase 2,Phase 3,Phase 1
40 Purinergic P2Y Receptor Antagonists Phase 4,Phase 2,Phase 3,Phase 1
41 Vasodilator Agents Phase 4,Phase 2
42 Antipruritics Phase 4
43 Dermatologic Agents Phase 4
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
45 Antiemetics Phase 4,Phase 2
46 Antineoplastic Agents, Hormonal Phase 4,Phase 2
47 Autonomic Agents Phase 4,Phase 2
48 BB 1101 Phase 4,Phase 2
49 Dexamethasone acetate Phase 4,Phase 2 1177-87-3
50 Gastrointestinal Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 243)

# Name Status NCT ID Phase Drugs
1 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
2 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
3 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
4 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4 pregabalin;placebo
5 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
6 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
7 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
8 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
9 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
10 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
11 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
12 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
13 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
14 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
15 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
16 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
17 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
18 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
19 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
20 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Active, not recruiting NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
21 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
22 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
23 Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells Unknown status NCT01833585 Phase 3
24 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
25 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
26 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
27 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
28 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
29 An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Completed NCT01483898 Phase 3
30 Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI) Completed NCT01245335 Phase 3
31 Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions Completed NCT00566657 Phase 3
32 Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA) Completed NCT02454231 Phase 2, Phase 3
33 Bone Marrow Autograft in Limb Ischemia Completed NCT00904501 Phase 3
34 Drug Eluting Stents In The Critically Ischemic Lower Leg 2 Completed NCT01442636 Phase 2, Phase 3
35 Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries Completed NCT01630070 Phase 2, Phase 3
36 Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures Completed NCT00041925 Phase 2, Phase 3 CGT003 (E2F Duplex Decoy)
37 Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease Completed NCT00059657 Phase 3 Ecraprost in lipid emulsion
38 Efficacy, Tolerability and Safety of Intramuscular Injections of PLX PAD for the Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization Recruiting NCT03006770 Phase 3
39 Use of Indocyanine Green Angiography in Critical Limb Ischemia Recruiting NCT02820467 Phase 3
40 Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia Recruiting NCT02230527 Phase 2, Phase 3 Ticagrelor;Clopidogrel
41 An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) Recruiting NCT02856230 Phase 2, Phase 3
42 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM Recruiting NCT03174522 Phase 3 Rexmyelocel-T;Placebo
43 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM Recruiting NCT03111238 Phase 3 Rexmyelocel-T;Placebo
44 PTA and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia Active, not recruiting NCT00471289 Phase 2, Phase 3
45 Safety and Efficacy Study of Autologous Bone Marrow Aspirate Concentrate for No-Option Critical Limb Ischemia Active, not recruiting NCT01818310 Phase 2, Phase 3
46 Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System Not yet recruiting NCT02538978 Phase 3
47 Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI) Not yet recruiting NCT03423732 Phase 2, Phase 3 CardioCell;Placebos
48 Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs Not yet recruiting NCT03042572 Phase 2, Phase 3 Allogeneic Mesenchymal Stromal Cell
49 Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia Terminated NCT02144610 Phase 3
50 Safety and Efficacy Study of Urokinase for the Treatment of Diabetic Foot Syndrome and Critical Limb Ischemia Terminated NCT01638585 Phase 3 urokinase

Search NIH Clinical Center for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACP-01, autologous angiogenic precursor cells for critical limb ischemia
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for critical limb ischemia
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
PDA002, Placenta-derived cells for vascular disease
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
ReN009, human neural stem cells for peripheral arterial disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Angiogenic cell precursors
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 9020076 23192920 22163120
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Bone marrow-derived mononuclear cells (family) PMIDs: 23586040 17394441 21216483
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC) PMIDs: 15995108 22019148 19500466 19896796 18351022
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells PMIDs: 23586040 17394441
Bone marrow-derived mesenchymal stem cells PMIDs: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells PMIDs: 18005405 18713449 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T) PMIDs: 22453769 22776246 21684715
Bone marrow-derived mononuclear cells PMIDs: 21586448
Bone marrow-derived mesenchymal stem cells PMIDs: 21586448
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Placenta-derived cells
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX) PMIDs: 18154467 19526389 19478280
Neural stem cell line (CTX0E03) PMIDs: 23067568
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 23307180 18720444 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

Anatomical Context for Critical Limb Ischemia

MalaCards organs/tissues related to Critical Limb Ischemia:

38
Bone, Bone Marrow, Endothelial, Smooth Muscle, Skin, Monocytes, Small Intestine
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
# Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
3 Placenta Chorionic Villus Chorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Critical Limb Ischemia

Articles related to Critical Limb Ischemia:

(show top 50) (show all 677)
# Title Authors Year
1
Endovascular Distal Plantar Vein Arterialization in Dialysis Patients With No-Option Critical Limb Ischemia and Posterior Tibial Artery Occlusion: A Technique for Limb Salvage in a Challenging Patient Subset. ( 29264998 )
2018
2
Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )
2018
3
The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )
2018
4
Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )
2018
5
Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )
2018
6
Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )
2018
7
Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )
2018
8
Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )
2018
9
Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )
2018
10
The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )
2018
11
Successful limb salvage from critical limb ischemia with bilateral variant anatomy of infrapopliteal arteries. ( 29275511 )
2017
12
Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry. ( 28807382 )
2017
13
Decision-Making in Critical Limb Ischemia: A Markov Simulation. ( 28739455 )
2017
14
Fractional flow reserve in below the knee arteries with critical limb ischemia and validation against gold-standard morphologic, functional measures and long term clinical outcomes. ( 28866449 )
2017
15
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
16
Thrombolytic therapy for critical limb ischemia in a Jehovah's Witness with severe anemia. ( 29349406 )
2017
17
Letter by Czihal and Hoffmann Regarding Article, "Prevalence of Tibial Artery and Pedal Arch Patency by Angiography in Patients With Critical Limb Ischemia and Noncompressible Ankle Brachial Index". ( 28916606 )
2017
18
Prevalence and Impact of Critical Limb Ischemia on In-Hospital Outcome in Transcatheter Aortic Valve Implantation in Germany. ( 28870876 )
2017
19
Predictive Parameters for Clinical Outcome in Patients with Critical Limb Ischemia Who Underwent Percutaneous Transluminal Angioplasty (PTA): A Systematic Review. ( 28924874 )
2017
20
Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia. ( 28848442 )
2017
21
Risk of major amputation or death among patients with critical limb ischemia initially treated with endovascular intervention, surgical bypass, minor amputation, or conservative management. ( 28760065 )
2017
22
The Effect of Charcot Neuroarthropathy on Limb Preservation in Diabetic Patients with Foot Wound and Critical Limb Ischemia after Balloon Angioplasty. ( 28951878 )
2017
23
A nationwide analysis of 30-day readmissions related to critical limb ischemia. ( 28836900 )
2017
24
A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia. ( 29358955 )
2017
25
Reduced amputation rate with isovolemic hemodilution in critical limb ischemia patients. ( 28922142 )
2017
26
Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia. ( 28790926 )
2017
27
Switch to Ticagrelor in critical limb ischemia antiplatelet study (STT-CLIPS). ( 29329963 )
2017
28
Association Between Preoperative Frailty and Mortality in Patients With Critical Limb Ischemia Following Infrainguinal Bypass Surgerya88- Usefulness of the Barthel Index. ( 28835590 )
2017
29
High and immeasurable ankle-brachial index as predictor ofA poor amputation-free survival in critical limb ischemia. ( 29290494 )
2017
30
Long-Term Outcomes of Successful Endovascular Therapy Via the Retrograde Approach for Below-the-Knee Chronic Total Occlusion in Patients With Critical Limb Ischemia After a Failed Antegrade Approach. ( 28045669 )
2017
31
Characteristics and clinical outcomes of repeat endovascular therapy after infrapopliteal balloon angioplasty in patients with critical limb ischemia. ( 28799724 )
2017
32
Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. ( 28900239 )
2017
33
Comparison of drug eluting balloon angioplasty to infrapopliteal artery critical lesions with or without additional pedal artery angioplasty in patients with diabetes mellitus and critical limb ischemia. ( 29250834 )
2017
34
Three-Year Outcomes of Surgical Versus Endovascular Revascularization for Critical Limb Ischemia: The SPINACH Study (Surgical Reconstruction Versus Peripheral Intervention in Patients With Critical Limb Ischemia). ( 29246911 )
2017
35
Ghrelin, MicroRNAs, and Critical Limb Ischemia: Hungering for a Novel Treatment Option. ( 29326658 )
2017
36
Staged endovascular repair of critical limb ischemia in high risk patients: the procedural and clinical outcomes. ( 28884985 )
2017
37
Evaluation of Chitotriosidase as a Marker of Inflammatory Status in Critical Limb Ischemia. ( 29263045 )
2017
38
Analysis of IN.PACT DEEP trial on the association between changes in perfusion from pre- to postrevascularization and clinical outcomes in critical limb ischemia. ( 28862375 )
2017
39
Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )
2017
40
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products. ( 27914820 )
2017
41
Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (rutherford clinical category 4-6). ( 28876565 )
2017
42
Coronary Artery Disease in Patients with Critical Limb Ischemia Undergoing Major Amputation or Not. ( 28740785 )
2017
43
Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia. ( 28042626 )
2017
44
Isolated lower extremity vasculitis leading to progressive critical limb ischemia. ( 29349396 )
2017
45
Outcomes of Critical Limb Ischemia in an Urban, Safety Net Hospital Population with High WIfI Amputation Scores. ( 27546850 )
2016
46
TCT-792 Non-Invasive Hemodynamics Poorly Predict Disease Severity and Response to Endovascular Therapy in Patients with Critical Limb Ischemia. ( 27970180 )
2016
47
Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia. ( 27021473 )
2016
48
Activation of the Pro-Oxidant PKCI^II-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia. ( 27600065 )
2016
49
The Mid-Term Clinical Follow-Up Using Drug-Eluting Balloons on Tibial Artery "De Novo" Lesions in Patients With Critical Limb Ischemia: A Cohort Study. ( 27206745 )
2016
50
Quality of life assessment as an outcomes measure in critical limb ischemia. ( 27876523 )
2016

Variations for Critical Limb Ischemia

Expression for Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for Critical Limb Ischemia

Pathways related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 ANGPT2 HGF IL6 TEK TNF VEGFA
2
Show member pathways
13.31 ANGPT2 HGF IL6 TEK TNF VEGFA
3
Show member pathways
13.19 ANGPT2 HGF IL6 TEK TNF VEGFA
4
Show member pathways
13.16 ANGPT2 HGF IL6 TEK TNF
5
Show member pathways
13.11 HGF IL6 TEK TNF VEGFA
6
Show member pathways
13.07 ANGPT2 HGF TEK VEGFA
7
Show member pathways
13.05 ANGPT2 HGF IL6 TEK TNF
8
Show member pathways
13.02 HGF IL6 TEK TNF VEGFA
9
Show member pathways
12.54 ANGPT2 HGF TEK VEGFA
10
Show member pathways
12.49 HGF IL6 TNF
11
Show member pathways
12.38 ANGPT2 IL6 TEK TNF
12 12.38 ANGPT2 HGF TEK TNF VEGFA
13
Show member pathways
12.36 ANGPT2 IL6 TNF VEGFA
14 12.12 HGF TNF VEGFA
15 12.02 IL6 TNF VEGFA
16 12.01 IL6 TNF VEGFA
17
Show member pathways
11.92 ANGPT2 HGF IL6 TEK TNF VEGFA
18 11.91 HGF IL6 VEGFA
19 11.76 IL6 TNF VEGFA
20 11.68 ANGPT2 HGF TEK
21 11.61 HGF IL6 TNF VEGFA
22 11.5 HGF IL6 TNF
23
Show member pathways
11.49 IL6 TNF VEGFA
24 11.46 ANGPT2 IL6 TEK VEGFA
25 11.43 IL6 TNF
26 11.4 IL6 VEGFA
27 11.4 IL6 TNF
28 11.37 IL6 TNF
29 11.36 IL6 TNF
30 11.36 TNF VEGFA
31 11.33 IL6 TNF
32 11.32 HGF IL6 TNF
33
Show member pathways
11.3 HGF VEGFA
34 11.29 HGF IL6 VEGFA
35 11.24 ANGPT2 VEGFA
36 11.21 IL6 TNF
37 11.21 IL6 TNF
38 11.21 IL6 TEK TNF VEGFA
39 11.16 IL6 TNF
40 11.15 IL6 TNF
41 11.13 IL6 TNF
42 11.03 TEK VEGFA
43 10.98 IL6 TNF
44 10.94 ANGPT2 HGF IL6 TNF
45 10.91 IL6 TNF
46 10.67 ANGPT2 HGF IL6 TEK TNF

GO Terms for Critical Limb Ischemia

Cellular components related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ANGPT2 HGF IL6 TNF VEGFA
2 extracellular region GO:0005576 9.1 ANGPT2 HGF IL6 TEK TNF VEGFA

Biological processes related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.9 HGF IL6 TNF VEGFA
2 positive regulation of gene expression GO:0010628 9.8 IL6 TNF VEGFA
3 MAPK cascade GO:0000165 9.75 HGF TEK TNF
4 angiogenesis GO:0001525 9.73 ANGPT2 TEK VEGFA
5 negative regulation of apoptotic process GO:0043066 9.73 HGF IL6 TEK VEGFA
6 leukocyte migration GO:0050900 9.7 ANGPT2 TEK TNF
7 response to hypoxia GO:0001666 9.67 ANGPT2 TEK VEGFA
8 regulation of receptor activity GO:0010469 9.67 HGF IL6 TNF VEGFA
9 response to glucocorticoid GO:0051384 9.65 IL6 TNF
10 positive regulation of MAP kinase activity GO:0043406 9.65 TNF VEGFA
11 positive regulation of protein phosphorylation GO:0001934 9.65 TEK TNF VEGFA
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.64 IL6 TNF
13 humoral immune response GO:0006959 9.64 IL6 TNF
14 positive regulation of osteoblast differentiation GO:0045669 9.63 HGF IL6
15 positive regulation of protein kinase B signaling GO:0051897 9.63 HGF TEK TNF
16 negative regulation of fat cell differentiation GO:0045599 9.62 IL6 TNF
17 positive regulation of endothelial cell migration GO:0010595 9.62 TEK VEGFA
18 positive regulation of cell adhesion GO:0045785 9.61 TNF VEGFA
19 positive regulation of interleukin-6 production GO:0032755 9.61 IL6 TNF
20 animal organ regeneration GO:0031100 9.59 ANGPT2 HGF
21 positive chemotaxis GO:0050918 9.58 HGF VEGFA
22 negative regulation of interleukin-6 production GO:0032715 9.57 HGF TNF
23 positive regulation of focal adhesion assembly GO:0051894 9.55 TEK VEGFA
24 positive regulation of protein complex assembly GO:0031334 9.54 TNF VEGFA
25 positive regulation of chemokine production GO:0032722 9.51 IL6 TNF
26 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 HGF IL6 VEGFA
27 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 IL6 TNF VEGFA
28 negative regulation of lipid storage GO:0010888 9.4 IL6 TNF
29 glomerulus vasculature development GO:0072012 9.16 ANGPT2 TEK
30 Tie signaling pathway GO:0048014 8.96 ANGPT2 TEK
31 positive regulation of angiogenesis GO:0045766 8.92 ANGPT2 HGF TEK VEGFA

Molecular functions related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 HGF VEGFA
2 cytokine activity GO:0005125 9.13 IL6 TNF VEGFA
3 growth factor activity GO:0008083 8.8 HGF IL6 VEGFA

Sources for Critical Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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