CLI
MCID: CRT049
MIFTS: 60

Critical Limb Ischemia (CLI) malady

Summaries for Critical Limb Ischemia

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32MalaCards
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MalaCards: Critical Limb Ischemia, also known as CLI, is related to ischemia and peripheral vascular disease. An important gene associated with Critical Limb Ischemia is APOM (apolipoprotein M), and among its related pathways are Malaria and Tyrosine Kinases / Adaptors. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Critical Limb Ischemia

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30LifeMap Discovery™, 44Novoseek, 60UMLS
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Aliases & Descriptions:

critical limb ischemia 30 44 60
cli 30 44


Related Diseases for Critical Limb Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Critical Limb Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia32.2SELE, TEK, PGF, FGF2, FGF1, FGF4
2peripheral vascular disease30.8SELE, VWF, APOA1
3intermittent claudication30.7VWF, FGF2
4diabetes mellitus30.7APOA1, EDN1, ANGPT2, SELE, TEK, THBD
5vascular disease30.5APOA1, APOH, EDN1, ANGPT2, FGF2, VWF
6hyperhomocysteinemia30.4SELE, THBD, VWF, APOH
7uremia30.2VWF
8systemic scleroderma30.2EDN1
9hypertension30.2SELE, PGF, EDN1, APOA1
10coronary artery disease30.1APOA1, SELE, TEK, THBD, VWF, PGF
11atherosclerosis30.1APOA1, APOM, SELE, TEK, THBD, THBS1
12colorectal cancer29.9HGF, ANGPT2, CD40, PGF, THBS1, TEK
13lung cancer29.9HGF, ANGPT2, CD40, AXL, THBS1, TEK
14breast cancer29.9HGF, ANGPT2, NGFR, AXL, FGF4, FGF1
15diabetic foot ulcers10.4
16thromboangiitis obliterans10.3
17spinal cord ischemia10.3
18ischemic neuropathy10.1
19pyoderma gangrenosum10.1
20thoracic aortic aneurysm10.1
21aortic aneurysm10.1
22brain disease10.1
23neuropathy10.1
24pyoderma10.1
25scleroderma10.1
26hepatitis10.0HGF
27multiple myeloma10.0CD40
28hyperthyroidism10.0CD40
29myeloid leukemia10.0AXL
30leiomyoma10.0FGF1
31pneumonia10.0CD40
32nephritis10.0APOH
33eclampsia10.0THBD
34disseminated intravascular coagulation10.0THBD
35hemangiopericytoma10.0NGFR
36kawasaki disease10.0SELE
37myelodysplastic syndromes10.0FGF1
38arteriosclerosis obliterans10.0HGF
39biliary atresia10.0HGF
40meningioma10.0PGF
41hyperglycemia10.0SELE
42goiter10.0TEK
43hepatitis b10.0APOA1
44nephrotic syndrome10.0APOA1
45wilms tumor10.0THBS1
46migraine10.0APOH
47glomerulonephritis10.0AXL, GAS6
48deficiency anemia10.0VWF
49hepatopulmonary syndrome10.0EDN1
50cor pulmonale10.0EDN1

Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to critical limb ischemia

Clinical Features for Critical Limb Ischemia

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Drugs & Therapeutics for Critical Limb Ischemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Critical Limb Ischemia

Drug clinical trials:

Search ClinicalTrials for Critical Limb Ischemia

Search NIH Clinical Center for Critical Limb Ischemia

Search CenterWatch for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous angiogenic cell precursors for the treatment of critical limb ischemia
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 9020076, 23192920, 22163120
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells, PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMID: 21216483
Bone marrow-derived mesenchymal stem cells , PMID: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells , PMIDs: 18005405, 18713449, 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T), PMIDs: 22453769, 22776246, 21684715
Bone marrow-derived mononuclear cells, PMID: 21586448
Bone marrow-derived mesenchymal stem cells, PMID: 21586448
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19526389, 19478280
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMIDs: 23307180, 18720444, 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

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Anatomical Context for Critical Limb Ischemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Critical Limb Ischemia:

32
Bone, Bone marrow, Endothelial, Monocytes, Spinal cord, Skin, Brain

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Critical Limb Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Critical Limb Ischemia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2ANGPT2
2MP:00036319.8FGF1, AXL, NGFR, EDN1
3MP:00053919.5ANGPT2, NGFR, AXL, FGF2, THBS1, SELE
4MP:00053709.2HGF, APOA1, NGFR, AXL, THBS1, THBD
5MP:00028738.7EDN1, NGFR, CD40, AXL, FGF4, FGF1
6MP:00053858.6EDN1, GAS6, APOA1, HGF, ANGPT2, NGFR
7MP:00053878.5APOA1, GAS6, ANGPT2, NGFR, CD40, AXL
8MP:00053768.5SELE, APOA1, APOM, APOH, GAS6, NGFR
9MP:00053848.4HGF, APOA1, GAS6, NGFR, CD40, AXL
10MP:00053978.3CD40, NGFR, GAS6, APOA1, HGF, AXL
11MP:00107688.0NGFR, ANGPT2, EDN1, GAS6, APOH, HGF

Publications for Critical Limb Ischemia

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50PubMed
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Articles related to Critical Limb Ischemia:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Prognosis of critical limb ischemia in hemodialysis patients after isolated infrapopliteal balloon angioplasty: results from the Japan below-the-knee artery treatment (J-BEAT) registry. (23391091)
2013
2
Clinically-driven need for secondary interventions after endovascular revascularization of tibial arteries in patients with critical limb ischemia. (24093325)
2013
3
Role of serum levels of angiogenic cytokines in assessment of angiogenesis after stem cell therapy of diabetic patients with critical limb ischemia. (24148204)
2013
4
Long-term outcomes of direct and indirect below-the-knee open revascularization based on the angiosome concept in diabetic patients with critical limb ischemia. (24333196)
2013
5
Open versus endoscopic great saphenous vein harvest for lower extremity revascularization of critical limb ischemia. (24103407)
2013
6
A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia. (23758736)
2013
7
Davies lends editorial expertise to follow-up issue on critical limb ischemia. (23805335)
2013
8
Percutaneous angioplasty of long tibial occlusions in critical limb ischemia. (23993107)
2013
9
Stem cell therapy for critical limb ischemia: what can we learn from cell therapy for chronic wounds? (23086986)
2012
10
Critical limb ischemia: introduction. (23342180)
2012
11
Cellular therapy with Ixmyelocel-T to treat critical limb ischemia: the randomized, double-blind, placebo-controlled RESTORE-CLI trial. (22453769)
2012
12
Critical limb ischemia: reporting outcomes and quality. (23342183)
2012
13
Comparison of initial hemodynamic response after endovascular therapy and open surgical bypass in patients with diabetes mellitus and critical limb ischemia. (22840897)
2012
14
Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. (22498564)
2012
15
Diagnostic accuracy of dynamic computed tomographic angiographic of the lower leg in patients with critical limb ischemia. (22543967)
2012
16
Basic data related to endovascular management of peripheral arterial disease in critical limb ischemia. (22704191)
2012
17
Predictors of failure of endovascular revascularization for critical limb ischemia. (22968240)
2012
18
Cell therapy in critical limb ischemia: current developments and future progress. (22731756)
2012
19
A framework for the evaluation of "value" and cost-effectiveness in the management of critical limb ischemia. (21943802)
2011
20
Advances in the treatment of acute thrombotic and chronic critical limb ischemia. (21792152)
2011
21
Assessment of macro- and microcirculation in contemporary critical limb ischemia. (21805568)
2011
22
Value of drug-eluting stents after failed percutaneous transluminal angioplasty in the infrapopliteal vessels for the treatment of critical limb ischemia: favorable mid-term patency and limb salvage results. (21792153)
2011
23
Skin perfusion pressure measurement to assess improvement in peripheral circulation after arterial reconstruction for critical limb ischemia. (23555459)
2011
24
Cell therapy for critical limb ischemia: moving forward one step at a time. (21325196)
2011
25
Impact of renal insufficiency on clinical outcomes in patients with critical limb ischemia undergoing endovascular revascularization. (21531529)
2011
26
Bare nitinol stent enabled recanalization of long-segment, chronic total occlusion of superficial femoral and adjacent proximal popliteal artery in diabetic patients presenting with critical limb ischemia. (20934655)
2010
27
Spontaneous aortic arch thrombus presenting as acute critical limb ischemia. (20308165)
2010
28
The influence of glycemic control on the prognosis of Japanese patients undergoing percutaneous transluminal angioplasty for critical limb ischemia. (20843974)
2010
29
The use of the cryoplasty technique in the treatment of infrapopliteal lesions for Critical Limb Ischemia patients in a routine hospital setting: one-year outcome of the Cryoplasty CLIMB Registry. (20354489)
2010
30
Below the knee PTA in critical limb ischemia results after 12 months: single center experience. (20462719)
2010
31
Successful bone marrow transplantation reveals the lack of endothelial progenitor cells mobilization in a patient with critical limb ischemia: a case report. (20832596)
2010
32
Peripheral chronic total occlusion in patients with critical limb ischemia. (20665866)
2010
33
Comment on: Below-Knee Bare Nitinol Stent Placement in High-risk Patients with Critical Limb Ischemia and Unlimited Supragenicular Inflow as Treatment of Choice "K.P. Donas, A. Schwindt, T. SchAPnefeld, J. Tessarek, G. Torsello". (19328025)
2009
34
Chronic critical limb ischemia: European experiences. (19741580)
2009
35
Infrapopliteal balloon angioplasty for chronic critical limb ischemia in diabetic patients with uremia: when is it worth the effort? (19157896)
2009
36
Clinical utility of 3 French infrapopliteal intervention in the setting of critical limb ischemia. (19652249)
2009
37
Primary cryoplasty therapy provides durable support for limb salvage in critical limb ischemia patients with infrapopliteal lesions: 12-month follow-up results from the BTK Chill Trial. (19624073)
2009
38
24-carat gold, 14-carat gold, or platinum standards in the treatment of critical limb ischemia: bypass surgery or endovascular intervention? (19317578)
2009
39
Improvement in systemic endothelial condition following amputation in patients with critical limb ischemia. (18974704)
2008
40
Impact of femoropopliteal bypass surgery on the survival and amputation rate of end-stage renal disease patients with critical limb ischemia. (17323017)
2007
41
Predictive values of transcutaneous oxygen tension for above-the-ankle amputation in diabetic patients with critical limb ischemia. (17296318)
2007
42
A population-based study of peripheral arterial disease prevalence with special focus on critical limb ischemia and sex differences. (17543683)
2007
43
Endovascular therapy for limb salvage in a case of critical lower limb ischemia resulting from fibromuscular dysplasia. (17903659)
2007
44
A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study. (17652878)
2007
45
Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience. (17309918)
2007
46
Critical limb ischemia and stem cell research: anchoring hope with informed adverse event reporting. (17159073)
2006
47
Prospective multicenter study of quality of life before and after lower extremity vein bypass in 1404 patients with critical limb ischemia. (17098529)
2006
48
Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient. (16939072)
2006
49
Arteriogenic gene therapy in patients with unreconstructable critical limb ischemia: a randomized, placebo-controlled clinical trial of adenovirus 5-delivered fibroblast growth factor-4. (16218781)
2005
50
Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial. (12866606)
2003

Genetic Variations for Critical Limb Ischemia

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Expression for genes affiliated with Critical Limb Ischemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for genes affiliated with Critical Limb Ischemia

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Sources:
29KEGG, 4Cell Signaling Technology, 53Reactome, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD40
210.2FGF1, AXL
310.1FGF2, FGF1
4
Hide members
9.8FGF2, FGF1, FGF4
59.8FGF4, FGF1, FGF2
6
Hide members
9.8C4BPB, VWF, THBD
79.7TEK, FGF2, FGF1, ANGPT2
8
Hide members
9.7HGF, GAS6, NGFR, PGF
9
Hide members
9.7NGFR, FGF4, FGF1, FGF2
10
Hide members
9.6GAS6, AXL, FGF4, PGF
11
Hide members
9.6THBS1, VWF, PGF, HGF
129.6GAS6, ANGPT2, THBD, TEK, SELE
13
Hide members
9.5HGF, APOA1, GAS6, VWF, THBS1
14
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9.5NGFR, FGF4, FGF1, FGF2, THBS1
15
Hide members
9.5HGF, ANGPT2, NGFR, CD40, AXL, TEK
169.5HGF, FGF4, FGF1, FGF2, THBS1
17
Hide members
9.5HGF, FGF4, FGF1, FGF2, THBS1
18
Hide members
9.5VWF, THBS1, THBD, TEK, SELE
19
Hide members
9.3C4BPB, CD40, FGF4, FGF1, FGF2, HGF
20
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
21
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
22
Hide members
8.9HGF, GAS6, ANGPT2, NGFR, FGF4, FGF1
23
Hide members
8.9HGF, GAS6, AXL, FGF4, FGF1, FGF2
24
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
25
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
26
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
27
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
28
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
29
Hide members
8.6NGFR, ANGPT2, GAS6, HGF, AXL, FGF4
30
Hide members
8.6APOA1, EDN1, NGFR, FGF4, FGF1, FGF2
318.5TEK, HGF, ANGPT2, NGFR, FGF4, FGF1

Compounds for genes affiliated with Critical Limb Ischemia

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7APOH
2cycloheximide4410.5HGF
3dexamethasone44 49 28 1113.2HGF, ANGPT2, FGF2, FGF1
4phosphatidylserine44 28 1112.2C4BPB, AXL, APOH, GAS6
5kininogen4410.1VWF, APOH, THBS1
6Pentosan Polysulfate1110.0FGF4, FGF1, FGF2
7warfarin44 49 11 2413.0GAS6, AXL, FGF2, VWF, APOH
86-ketoprostaglandin f1alpha4410.0THBD, APOH, EDN1, VWF
9creatinine449.9SELE, ANGPT2, APOH, APOA1, THBD
10dermatan sulfate449.9VWF, HGF, FGF1, FGF2, THBD
11txb2449.8EDN1, THBD, THBS1, VWF, APOH
12cyclosporin a44 28 5911.8THBD, THBS1, FGF2, CD40, EDN1, ANGPT2
13fluvastatin44 49 28 1112.8VWF, THBD, SELE, CD40, APOA1
14dextran sulfate449.7SELE, HGF, APOA1, APOH, FGF1, THBS1
15prednisolone44 28 1111.7FGF2, THBD, HGF, VWF, CD40, APOH
16heparin44 28 11 2412.7FGF4, APOH, SELE, C4BPB, PGF
17infliximab44 49 1111.7SELE, FGF2, APOA1, APOH, ANGPT2, TEK
18serine449.7TEK, THBS1, FGF1, C4BPB, FGF2, SELE
19N,O6-Disulfo-Glucosamine119.7HGF, FGF1, FGF2
20pge1449.6VWF, THBD, CD40, HGF, APOH
21hyaluronic acid44 2410.6FGF2, THBD, THBS1, VWF, FGF1, HGF
22losartan44 49 28 1112.6SELE, VWF, EDN1, HGF, THBD
23heparan sulfate44 2410.6FGF2, HGF, FGF4, FGF1, THBD, THBS1
24cyclophosphamide44 49 1111.6THBD, VWF, APOH, HGF, THBS1, SELE
25ly294002449.5THBS1, ANGPT2, SELE, HGF, GAS6, CD40
26wortmannin449.5GAS6, THBS1, PGF, AXL, CD40, NGFR
27matrigel449.4FGF1, SELE, THBS1, PGF, FGF4, NGFR
28histamine44 28 2411.4EDN1, HGF, NGFR, CD40, VWF, THBD
29phospholipid449.4CD40, C4BPB, VWF, APOA1, APOM, APOH
30actinomycin d449.4HGF, EDN1, FGF1, FGF2, THBD, SELE
31oxygen44 2410.4TEK, FGF4, HGF, ANGPT2, PGF, FGF1
32genistein44 28 59 2 11 2414.3CD40, THBS1, SELE, HGF, APOA1, EDN1
33fibrinogen449.3CD40, APOA1, SELE, THBD, APOH, ANGPT2
34thymidine44 2410.3TEK, THBS1, FGF2, FGF1, CD40, ANGPT2
35aspirin44 49 28 2412.3THBD, HGF, APOA1, APOH, VWF, SELE
36agar449.3FGF2, FGF1, FGF4, THBS1, HGF, NGFR
37atorvastatin44 49 28 11 2413.2THBD, THBS1, SELE, VWF, PGF, CD40
38glucose449.2PGF, APOA1, APOM, APOH, CD40, THBS1
39h2o2449.2THBD, VWF, FGF2, FGF1, APOA1, ANGPT2
40lactate449.1SELE, THBD, VWF, HGF, APOA1, APOH
41paraffin448.9FGF1, TEK, THBD, THBS1, VWF, PGF
42alanine448.9HGF, APOA1, C4BPB, THBS1, FGF1, THBD
43cholesterol44 28 11 2411.8FGF1, APOA1, APOM, NGFR, CD40, FGF4
44retinoic acid44 249.8CD40, HGF, FGF1, VWF, THBD, THBS1
45lipid448.8THBS1, SELE, PGF, THBD, HGF, APOA1
46prostacyclin448.7VWF, THBS1, THBD, PGF, FGF2, HGF
47phosphatidylinositol448.6HGF, TEK, APOH, GAS6, EDN1, NGFR
48nitric oxide44 11 2410.6THBD, SELE, EDN1, ANGPT2, NGFR, TEK
49tyrosine448.3HGF, AXL, CD40, NGFR, ANGPT2, GAS6
50vegf447.9HGF, APOH, GAS6, EDN1, ANGPT2, NGFR

GO Terms for genes affiliated with Critical Limb Ischemia

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Sources:
16Gene Ontology
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Cellular components related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.1THBS1, VWF
2very-low-density lipoprotein particleGO:0343619.9APOH, APOM, APOA1
3platelet alpha granule lumenGO:0310939.9HGF, GAS6, VWF, THBS1
4high-density lipoprotein particleGO:0343649.8APOA1, APOM, APOH
5spherical high-density lipoprotein particleGO:0343669.8APOM, APOA1
6cell surfaceGO:0099869.5APOH, NGFR, AXL, THBS1, THBD, TEK
7extracellular spaceGO:0056158.4HGF, APOA1, APOH, GAS6, EDN1, ANGPT2
8extracellular regionGO:0055767.7TEK, HGF, APOA1, GAS6, C4BPB, EDN1

Biological processes related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dendritic cell apoptotic processGO:200066910.6GAS6, AXL
2positive regulation of cytokine-mediated signaling pathwayGO:00196110.5GAS6, AXL
3cellular response to interferon-alphaGO:03545710.5AXL, GAS6
4Tie signaling pathwayGO:04801410.5ANGPT2, TEK
5dendritic cell differentiationGO:09702810.5GAS6, AXL
6high-density lipoprotein particle assemblyGO:03438010.5APOA1, APOM
7positive regulation of natural killer cell differentiationGO:03282510.5GAS6, AXL
8high-density lipoprotein particle clearanceGO:03438410.5APOA1, APOM
9negative regulation of smooth muscle cell apoptotic processGO:03439210.5APOH, EDN1
10enzyme linked receptor protein signaling pathwayGO:00716710.5GAS6, AXL
11positive regulation of endothelial cell apoptotic processGO:200035310.5CD40, THBS1
12negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.4APOA1, GAS6
13positive regulation of intracellular protein kinase cascadeGO:01074010.4FGF1, TEK
14chondroblast differentiationGO:06059110.4FGF2, FGF4
15negative regulation of blood vessel endothelial cell migrationGO:04353710.4ANGPT2, FGF2, THBS1
16negative regulation of fibroblast growth factor receptor signaling pathwayGO:04003710.4THBS1, NGFR
17negative regulation of fibrinolysisGO:05191810.4THBD, THBS1, APOH
18response to glucose stimulusGO:00974910.4THBS1, ANGPT2, APOM
19apoptotic cell clearanceGO:04327710.3GAS6, AXL
20negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.3HGF, GAS6, THBS1
21cell-substrate adhesionGO:03158910.3VWF, GAS6
22negative regulation of blood coagulationGO:03019510.3APOH, EDN1, THBD
23positive regulation of blood coagulationGO:03019410.3APOH, THBS1
24positive regulation of endothelial cell migrationGO:01059510.3TEK, THBS1, EDN1
25positive regulation of protein kinase B signaling cascadeGO:05189710.2GAS6, AXL, THBS1, TEK
26sprouting angiogenesisGO:00204010.2TEK, THBS1, PGF
27positive regulation of protein phosphorylationGO:00193410.2FGF1, FGF4, CD40, GAS6
28negative regulation of endothelial cell apoptotic processGO:200035210.2GAS6, TEK
29negative regulation of angiogenesisGO:01652510.2APOH, ANGPT2, THBS1, TEK
30positive regulation of cell migrationGO:03033510.2HGF, EDN1, FGF1, THBS1
31positive regulation of endothelial cell proliferationGO:00193810.2TEK, PGF, FGF2
32high-density lipoprotein particle remodelingGO:03437510.1APOM, APOA1
33positive regulation of ERK1 and ERK2 cascadeGO:07037410.1GAS6, FGF4, FGF2, TEK
34activation of MAPK activityGO:00018710.1THBS1, FGF2, HGF
35response to hypoxiaGO:00166610.0EDN1, ANGPT2, PGF, THBS1
36endothelial cell proliferationGO:00193510.0APOA1, TEK
37leukocyte migrationGO:05090010.0GAS6, ANGPT2, THBD, TEK, SELE
38organ inductionGO:00175910.0FGF2, FGF1
39positive regulation of cell divisionGO:05178110.0PGF, FGF2, FGF1, FGF4
40platelet degranulationGO:00257610.0HGF, APOA1, GAS6, VWF, THBS1
41organ regenerationGO:03110010.0HGF, APOA1, GAS6, ANGPT2, PGF
42neurotrophin TRK receptor signaling pathwayGO:0480119.9FGF2, FGF1, FGF4, NGFR
43negative regulation of endothelial cell migrationGO:0105969.8THBS1, APOH
44negative regulation of apoptotic processGO:0430669.8HGF, GAS6, NGFR, FGF4, THBS1, TEK
45cell-cell signalingGO:0072679.8EDN1, FGF4, PGF, TEK
46positive regulation of angiogenesisGO:0457669.7ANGPT2, FGF1, FGF2, PGF, THBS1, TEK
47positive regulation of cell proliferationGO:0082849.7EDN1, FGF4, FGF1, FGF2, PGF
48platelet activationGO:0301689.7HGF, APOA1, GAS6, CD40, AXL, VWF
49signal transductionGO:0071659.3GAS6, ANGPT2, AXL, FGF4, FGF1, FGF2
50blood coagulationGO:0075969.0SELE, HGF, APOA1, GAS6, C4BPB, ANGPT2

Molecular functions related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylserine bindingGO:00178610.1THBS1, AXL, GAS6
2fibroblast growth factor receptor bindingGO:0051049.8FGF2, FGF1, FGF4
3glycoprotein bindingGO:0019489.8APOH, VWF, THBS1
4growth factor activityGO:0080839.5HGF, FGF4, FGF1, FGF2, PGF
5receptor activityGO:0048729.5TEK, THBD, CD40, NGFR
6identical protein bindingGO:0428029.5APOA1, APOH, VWF, THBS1, HGF
7heparin bindingGO:0082019.4THBS1, PGF, FGF2, FGF1, FGF4, APOH
8protein bindingGO:0055157.7NGFR, ANGPT2, EDN1, GAS6, APOH, APOA1

Products for genes affiliated with Critical Limb Ischemia

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Sources for Critical Limb Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet