CLI
MCID: CRT049
MIFTS: 58

Critical Limb Ischemia (CLI) malady

Summaries for Critical Limb Ischemia

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33MalaCards
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MalaCards: Critical Limb Ischemia, also known as CLI, is related to peripheral vascular disease and intermittent claudication. An important gene associated with Critical Limb Ischemia is APOM (apolipoprotein M), and among its related pathways are Malaria and Tyrosine Kinases / Adaptors. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Critical Limb Ischemia

Sources:
45Novoseek, 31LifeMap Discovery™, 61UMLS
See all sources

Aliases & Descriptions:

critical limb ischemia 45 31 61
cli 45


Related Diseases for Critical Limb Ischemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Critical Limb Ischemia family:

critical limb ischemia with alias cli

Diseases related to Critical Limb Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral vascular disease30.8SELE, VWF, APOA1
2intermittent claudication30.8VWF, FGF2
3vascular disease30.5APOA1, APOH, EDN1, ANGPT2, FGF2, VWF
4hyperhomocysteinemia30.4SELE, THBD, VWF, APOH
5uremia30.2VWF
6systemic scleroderma30.2EDN1
7coronary artery disease,30.2APOA1, SELE, TEK, THBD, VWF, PGF
8atherosclerosis30.2APOA1, APOM, SELE, TEK, THBD, THBS1
9colorectal cancer30.0HGF, ANGPT2, CD40, PGF, THBS1, TEK
10critical limb ischemia with alias cli10.3
11thromboangiitis obliterans10.3
12spinal cord ischemia10.3
13hypoxia10.3
14diabetic foot ulcers10.2
15ischemic neuropathy10.2
16pyoderma gangrenosum10.2
17thoracic aortic aneurysm10.2
18aortic aneurysm10.2
19b cell deficiency10.2
20brain disease10.2
21t cell deficiency10.2
22devic disease10.2
23brain ischemia10.2
24hepatitis10.0HGF
25multiple myeloma10.0CD40
26hyperthyroidism10.0CD40
27myeloid leukemia10.0AXL
28leiomyoma10.0FGF1
29pneumonia10.0CD40
30nephritis10.0APOH
31eclampsia10.0THBD
32disseminated intravascular coagulation10.0THBD
33hemangiopericytoma10.0NGFR
34kawasaki disease10.0SELE
35myelodysplastic syndromes10.0FGF1
36arteriosclerosis obliterans10.0HGF
37biliary atresia10.0HGF
38meningioma10.0PGF
39hyperglycemia10.0SELE
40goiter10.0TEK
41hepatitis b10.0APOA1
42nephrotic syndrome10.0APOA1
43wilms tumor10.0THBS1
44migraine10.0APOH
45glomerulonephritis10.0AXL, GAS6
46deficiency anemia10.0VWF
47hepatopulmonary syndrome10.0EDN1
48cor pulmonale10.0EDN1
49retinal vein occlusion10.0APOH
50dermatomyositis10.0THBS1, CD40

Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to critical limb ischemia

Clinical Features for Critical Limb Ischemia

Drugs & Therapeutics for Critical Limb Ischemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Critical Limb Ischemia

Drug clinical trials:

Search ClinicalTrials for Critical Limb Ischemia

Search NIH Clinical Center for Critical Limb Ischemia

Search CenterWatch for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous angiogenic cell precursors for the treatment of critical limb ischemia
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 9020076, 23192920, 22163120
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells, PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMID: 21216483
Bone marrow-derived mesenchymal stem cells , PMID: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells , PMIDs: 18005405, 18713449, 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T), PMIDs: 22453769, 22776246, 21684715
Bone marrow-derived mononuclear cells, PMID: 21586448
Bone marrow-derived mesenchymal stem cells, PMID: 21586448
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19526389, 19478280
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMIDs: 23307180, 18720444, 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

Anatomical Context for Critical Limb Ischemia

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Critical Limb Ischemia:

33
Bone marrow, Whole blood, Brain, Spinal cord, Skin, Placenta, Monocytes, T cells, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Critical Limb Ischemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Critical Limb Ischemia

Sources:
51PubMed
See all sources

Articles related to Critical Limb Ischemia:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Endovascular management of critical limb ischemia in renal transplant patients. (24011817)
2014
2
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
3
A long-term outcome of therapeutic angiogenesis by transplantation of peripheral blood stem cells in critical limb ischemia after interventional revascularization. (23019056)
2013
4
Medical therapy for critical limb ischemia and the diabetic foot: an update. (24126505)
2013
5
Intra-arterial allogeneic mesenchymal stem cells for critical limb ischemia are safe and efficacious: report of a phase I study. (23307180)
2013
6
Alternative techniques for treatment of complex below-the knee arterial occlusions in diabetic patients with critical limb ischemia. (22278664)
2013
7
Lejay A, Thaveau F, Georg Y, Bajcz C, Kretz JG, ChakfAc N. Autonomy following revascularisation in 80-year-old patients with critical limb ischemia. Eur J Vasc Endovasc Surg 2012;44:562-7. (23528245)
2013
8
Superficial femoral artery TASC D Registry: twelve-month effectiveness analysis of the Pulsar-18 SE nitinol stent in patients with critical limb ischemia. (24013531)
2013
9
Therapeutic angiogenesis for the critical limb ischemia decreases platelet activation. (23534936)
2013
10
Neutrophil-to-lymphocyte ratio and its association with critical limb ischemia in PAOD patients. (23457609)
2013
11
Therapeutic angiogenesis improves fibrinolytic imbalance in patients with critical limb ischemia. (24300022)
2013
12
Changes in functional status after treatment of critical limb ischemia. (24075105)
2013
13
Atherectomy offers no benefits over balloon angioplasty in tibial interventions for critical limb ischemia. (23755978)
2013
14
Therapeutic angiogenesis in critical limb ischemia. (23129733)
2013
15
Comparison of clinical outcome of infrapopliteal angioplasty between Korean diabetic and non-diabetic patients with critical limb ischemia. (22112858)
2012
16
Endovascular treatment of popliteal artery segments P1 and P2 in patients with critical limb ischemia: initial experience using a helical nitinol stent with increased radial force. (22788900)
2012
17
Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. (22936457)
2012
18
Limb revascularization feasibility in diabetic patients with critical limb ischemia: results from a cohort of 344 consecutive unselected diabetic patients evaluated in 2009. (22104261)
2012
19
TRICKS magnetic resonance angiography at 3-tesla for assessing whole lower extremity vascular tree in patients with high-grade critical limb ischemia: DSA and TASC II guidelines correlations. (23304080)
2012
20
Cost-effectiveness in the contemporary management of critical limb ischemia with tissue loss. (22854267)
2012
21
Association of diabetes and hemodialysis with ankle pressure and ankle-brachial index in Japanese patients with critical limb ischemia. (22723344)
2012
22
A high CHA(2)DS(2)-VASc score is associated with a high risk for critical limb ischemia in peripheral arterial occlusive disease patients. (23102450)
2012
23
Socioeconomic and hospital-related predictors of amputation for critical limb ischemia. (21163610)
2011
24
Dual vascular access for critical limb ischemia: immediate and follow-up results. (20853371)
2011
25
Critical limb ischemia: endovascular strategies for limb salvage. (21722787)
2011
26
A case of mistaken identity: persistent sciatic artery stenosis as a cause of critical limb ischemia. (20824772)
2011
27
Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia. (21514773)
2011
28
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
29
Below knee bare nitinol stent placement in high-risk patients with critical limb ischemia is still durable after 24 months of follow-up. (20541349)
2010
30
Impact of implanted bone marrow progenitor cell composition on limb salvage after cell implantation in patients with critical limb ischemia. (19748620)
2010
31
Importance of the angiosome concept for endovascular therapy in patients with critical limb ischemia. (20306500)
2010
32
Functional status as a prognostic factor for primary revascularization for critical limb ischemia. (20141960)
2010
33
L-alanyl-glutamine preoperative infusion in patients with critical limb ischemia subjected to distal revascularization reduces tissue damage and protects from oxidative stress. (20371164)
2010
34
Is endovascular revascularisation worthwhile in diabetic patients with critical limb ischemia who also have end-stage renal disease? (21030104)
2010
35
Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia. (19747609)
2009
36
Value of MDCT angiography in developing treatment strategies for critical limb ischemia. (19380571)
2009
37
Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. (19548076)
2009
38
FDA perspective on objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia. (19897334)
2009
39
Autologous bone marrow stem cell transplantation in patients with end-stage chronical critical limb ischemia and diabetic foot. (19378841)
2009
40
Homocysteine, the cholesterol of the 21st century. Impact of hyperhomocysteinemia on patency and amputation-free survival after intervention for critical limb ischemia. (18729558)
2008
41
Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. (18559703)
2008
42
Design and rationale of a randomized, double-blind, placebo-controlled phase III study for autologous bone marrow cell transplantation in critical limb ischemia: the BONe Marrow Outcomes Trial in Critical Limb Ischemia (BONMOT-CLI). (19003741)
2008
43
Interventional management of critical limb ischemia in renal patients. (18805385)
2008
44
Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells. (19084740)
2008
45
Platelet activation in bypass surgery for critical limb ischemia. (18421039)
2008
46
Initial clinical experience with the 4-F self-expanding XPERT stent system for infrapopliteal treatment of patients with severe claudication and critical limb ischemia. (17538131)
2007
47
Female gender and oral anticoagulants are associated with wound complications in lower extremity vein bypass: an analysis of 1404 operations for critical limb ischemia. (18154995)
2007
48
Risk factors for development of critical limb ischemia -- a survey of diabetic vs. nondiabetic population. (17211294)
2006
49
Marked decrease of plasma VEGF after implantation of autologous bone marrow mononuclear cells in a patient with critical limb ischemia--a case report. (16518534)
2006
50
Plasma prothrombotic markers after a short- and middle term treatment with iloprost in arteriopathic patients with critical limb ischemia. (7530356)
1994

Genetic Variations for Critical Limb Ischemia

Expression for genes affiliated with Critical Limb Ischemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for genes affiliated with Critical Limb Ischemia

Sources:
30KEGG, 4Cell Signaling Technology, 54Reactome, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD40
210.2FGF1, AXL
310.1FGF2, FGF1
4
Hide members
9.8FGF2, FGF1, FGF4
59.8FGF4, FGF1, FGF2
6
Hide members
9.8C4BPB, VWF, THBD
79.7TEK, FGF2, FGF1, ANGPT2
8
Hide members
9.7HGF, GAS6, NGFR, PGF
9
Hide members
9.7NGFR, FGF4, FGF1, FGF2
10
Hide members
9.6GAS6, AXL, FGF4, PGF
11
Hide members
9.6THBS1, VWF, PGF, HGF
129.6GAS6, ANGPT2, THBD, TEK, SELE
13
Hide members
9.5HGF, APOA1, GAS6, VWF, THBS1
14
Hide members
9.5NGFR, FGF4, FGF1, FGF2, THBS1
15
Hide members
9.5HGF, ANGPT2, NGFR, CD40, AXL, TEK
169.5HGF, FGF4, FGF1, FGF2, THBS1
17
Hide members
9.5HGF, FGF4, FGF1, FGF2, THBS1
18
Hide members
9.5VWF, THBS1, THBD, TEK, SELE
19
Hide members
9.3C4BPB, CD40, FGF4, FGF1, FGF2, HGF
20
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
21
Hide members
9.1HGF, GAS6, NGFR, FGF4, FGF1, FGF2
22
Hide members
8.9HGF, GAS6, ANGPT2, NGFR, FGF4, FGF1
23
Hide members
8.9HGF, GAS6, AXL, FGF4, FGF1, FGF2
24
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
25
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
26
Hide members
8.8HGF, GAS6, NGFR, AXL, FGF4, FGF1
27
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
28
Hide members
8.6HGF, GAS6, ANGPT2, NGFR, AXL, FGF4
29
Hide members
8.6NGFR, ANGPT2, GAS6, HGF, AXL, FGF4
30
Hide members
8.6APOA1, EDN1, NGFR, FGF4, FGF1, FGF2
318.5TEK, HGF, ANGPT2, NGFR, FGF4, FGF1

Compounds for genes affiliated with Critical Limb Ischemia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7APOH
2cycloheximide4510.5HGF
3dexamethasone45 50 29 1113.2HGF, ANGPT2, FGF2, FGF1
4phosphatidylserine45 29 1112.2C4BPB, AXL, APOH, GAS6
5kininogen4510.1VWF, APOH, THBS1
6Pentosan Polysulfate1110.0FGF4, FGF1, FGF2
7warfarin45 50 11 2413.0GAS6, AXL, FGF2, VWF, APOH
86-ketoprostaglandin f1alpha4510.0THBD, APOH, EDN1, VWF
9creatinine459.9SELE, ANGPT2, APOH, APOA1, THBD
10dermatan sulfate459.9VWF, HGF, FGF1, FGF2, THBD
11txb2459.8EDN1, THBD, THBS1, VWF, APOH
12cyclosporin a45 29 6011.8THBD, THBS1, FGF2, CD40, EDN1, ANGPT2
13fluvastatin45 50 29 1112.8VWF, THBD, SELE, CD40, APOA1
14dextran sulfate459.7SELE, HGF, APOA1, APOH, FGF1, THBS1
15prednisolone45 29 1111.7FGF2, THBD, HGF, VWF, CD40, APOH
16heparin45 29 11 2412.7FGF4, APOH, SELE, C4BPB, PGF
17infliximab45 50 1111.7SELE, FGF2, APOA1, APOH, ANGPT2, TEK
18serine459.7TEK, THBS1, FGF1, C4BPB, FGF2, SELE
19N,O6-Disulfo-Glucosamine119.7HGF, FGF1, FGF2
20pge1459.6VWF, THBD, CD40, HGF, APOH
21hyaluronic acid45 2410.6FGF2, THBD, THBS1, VWF, FGF1, HGF
22losartan45 50 29 1112.6SELE, VWF, EDN1, HGF, THBD
23heparan sulfate45 2410.6FGF2, HGF, FGF4, FGF1, THBD, THBS1
24cyclophosphamide45 50 1111.6THBD, VWF, APOH, HGF, THBS1, SELE
25ly294002459.5THBS1, ANGPT2, SELE, HGF, GAS6, CD40
26wortmannin459.5GAS6, THBS1, PGF, AXL, CD40, NGFR
27matrigel459.4FGF1, SELE, THBS1, PGF, FGF4, NGFR
28histamine45 29 2411.4EDN1, HGF, NGFR, CD40, VWF, THBD
29phospholipid459.4CD40, C4BPB, VWF, APOA1, APOM, APOH
30actinomycin d459.4HGF, EDN1, FGF1, FGF2, THBD, SELE
31oxygen45 2410.4TEK, FGF4, HGF, ANGPT2, PGF, FGF1
32genistein45 29 60 2 11 2414.3CD40, THBS1, SELE, HGF, APOA1, EDN1
33fibrinogen459.3CD40, APOA1, SELE, THBD, APOH, ANGPT2
34thymidine45 2410.3TEK, THBS1, FGF2, FGF1, CD40, ANGPT2
35aspirin45 50 29 2412.3THBD, HGF, APOA1, APOH, VWF, SELE
36agar459.3FGF2, FGF1, FGF4, THBS1, HGF, NGFR
37atorvastatin45 50 29 11 2413.2THBD, THBS1, SELE, VWF, PGF, CD40
38glucose459.2PGF, APOA1, APOM, APOH, CD40, THBS1
39h2o2459.2THBD, VWF, FGF2, FGF1, APOA1, ANGPT2
40lactate459.1SELE, THBD, VWF, HGF, APOA1, APOH
41paraffin458.9FGF1, TEK, THBD, THBS1, VWF, PGF
42alanine458.9HGF, APOA1, C4BPB, THBS1, FGF1, THBD
43cholesterol45 29 11 2411.8FGF1, APOA1, APOM, NGFR, CD40, FGF4
44retinoic acid45 249.8CD40, HGF, FGF1, VWF, THBD, THBS1
45lipid458.8THBS1, SELE, PGF, THBD, HGF, APOA1
46prostacyclin458.7VWF, THBS1, THBD, PGF, FGF2, HGF
47phosphatidylinositol458.6HGF, TEK, APOH, GAS6, EDN1, NGFR
48nitric oxide45 11 2410.6THBD, SELE, EDN1, ANGPT2, NGFR, TEK
49tyrosine458.3HGF, AXL, CD40, NGFR, ANGPT2, GAS6
50vegf457.9HGF, APOH, GAS6, EDN1, ANGPT2, NGFR

GO Terms for genes affiliated with Critical Limb Ischemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granuleGO:03109110.1THBS1, VWF
2very-low-density lipoprotein particleGO:0343619.9APOH, APOM, APOA1
3platelet alpha granule lumenGO:0310939.9HGF, GAS6, VWF, THBS1
4high-density lipoprotein particleGO:0343649.8APOA1, APOM, APOH
5spherical high-density lipoprotein particleGO:0343669.8APOM, APOA1
6cell surfaceGO:0099869.5APOH, NGFR, AXL, THBS1, THBD, TEK
7extracellular spaceGO:0056158.4HGF, APOA1, APOH, GAS6, EDN1, ANGPT2
8extracellular regionGO:0055767.7TEK, HGF, APOA1, GAS6, C4BPB, EDN1

Biological processes related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dendritic cell apoptotic processGO:200066910.6GAS6, AXL
2positive regulation of cytokine-mediated signaling pathwayGO:00196110.5GAS6, AXL
3cellular response to interferon-alphaGO:03545710.5AXL, GAS6
4Tie signaling pathwayGO:04801410.5ANGPT2, TEK
5dendritic cell differentiationGO:09702810.5GAS6, AXL
6high-density lipoprotein particle assemblyGO:03438010.5APOA1, APOM
7positive regulation of natural killer cell differentiationGO:03282510.5GAS6, AXL
8high-density lipoprotein particle clearanceGO:03438410.5APOA1, APOM
9negative regulation of smooth muscle cell apoptotic processGO:03439210.5APOH, EDN1
10enzyme linked receptor protein signaling pathwayGO:00716710.5GAS6, AXL
11positive regulation of endothelial cell apoptotic processGO:200035310.5CD40, THBS1
12negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.4APOA1, GAS6
13positive regulation of intracellular protein kinase cascadeGO:01074010.4FGF1, TEK
14chondroblast differentiationGO:06059110.4FGF2, FGF4
15negative regulation of blood vessel endothelial cell migrationGO:04353710.4ANGPT2, FGF2, THBS1
16negative regulation of fibroblast growth factor receptor signaling pathwayGO:04003710.4THBS1, NGFR
17negative regulation of fibrinolysisGO:05191810.4THBD, THBS1, APOH
18response to glucose stimulusGO:00974910.4THBS1, ANGPT2, APOM
19apoptotic cell clearanceGO:04327710.3GAS6, AXL
20negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.3HGF, GAS6, THBS1
21cell-substrate adhesionGO:03158910.3VWF, GAS6
22negative regulation of blood coagulationGO:03019510.3APOH, EDN1, THBD
23positive regulation of blood coagulationGO:03019410.3APOH, THBS1
24positive regulation of endothelial cell migrationGO:01059510.3TEK, THBS1, EDN1
25positive regulation of protein kinase B signaling cascadeGO:05189710.2GAS6, AXL, THBS1, TEK
26sprouting angiogenesisGO:00204010.2TEK, THBS1, PGF
27positive regulation of protein phosphorylationGO:00193410.2FGF1, FGF4, CD40, GAS6
28negative regulation of endothelial cell apoptotic processGO:200035210.2GAS6, TEK
29negative regulation of angiogenesisGO:01652510.2APOH, ANGPT2, THBS1, TEK
30positive regulation of cell migrationGO:03033510.2HGF, EDN1, FGF1, THBS1
31positive regulation of endothelial cell proliferationGO:00193810.2TEK, PGF, FGF2
32high-density lipoprotein particle remodelingGO:03437510.1APOM, APOA1
33positive regulation of ERK1 and ERK2 cascadeGO:07037410.1GAS6, FGF4, FGF2, TEK
34activation of MAPK activityGO:00018710.1THBS1, FGF2, HGF
35response to hypoxiaGO:00166610.0EDN1, ANGPT2, PGF, THBS1
36endothelial cell proliferationGO:00193510.0APOA1, TEK
37leukocyte migrationGO:05090010.0GAS6, ANGPT2, THBD, TEK, SELE
38organ inductionGO:00175910.0FGF2, FGF1
39positive regulation of cell divisionGO:05178110.0PGF, FGF2, FGF1, FGF4
40platelet degranulationGO:00257610.0HGF, APOA1, GAS6, VWF, THBS1
41organ regenerationGO:03110010.0HGF, APOA1, GAS6, ANGPT2, PGF
42neurotrophin TRK receptor signaling pathwayGO:0480119.9FGF2, FGF1, FGF4, NGFR
43negative regulation of endothelial cell migrationGO:0105969.8THBS1, APOH
44negative regulation of apoptotic processGO:0430669.8HGF, GAS6, NGFR, FGF4, THBS1, TEK
45cell-cell signalingGO:0072679.8EDN1, FGF4, PGF, TEK
46positive regulation of angiogenesisGO:0457669.7ANGPT2, FGF1, FGF2, PGF, THBS1, TEK
47positive regulation of cell proliferationGO:0082849.7EDN1, FGF4, FGF1, FGF2, PGF
48platelet activationGO:0301689.7HGF, APOA1, GAS6, CD40, AXL, VWF
49signal transductionGO:0071659.3GAS6, ANGPT2, AXL, FGF4, FGF1, FGF2
50blood coagulationGO:0075969.0SELE, HGF, APOA1, GAS6, C4BPB, ANGPT2

Molecular functions related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylserine bindingGO:00178610.1THBS1, AXL, GAS6
2fibroblast growth factor receptor bindingGO:0051049.8FGF2, FGF1, FGF4
3glycoprotein bindingGO:0019489.8APOH, VWF, THBS1
4growth factor activityGO:0080839.5HGF, FGF4, FGF1, FGF2, PGF
5receptor activityGO:0048729.5TEK, THBD, CD40, NGFR
6identical protein bindingGO:0428029.5APOA1, APOH, VWF, THBS1, HGF
7heparin bindingGO:0082019.4THBS1, PGF, FGF2, FGF1, FGF4, APOH
8protein bindingGO:0055157.7NGFR, ANGPT2, EDN1, GAS6, APOH, APOA1

Products for genes affiliated with Critical Limb Ischemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Critical Limb Ischemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet