CLI
MCID: CRT049
MIFTS: 49

Critical Limb Ischemia (CLI) malady

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Summaries for Critical Limb Ischemia

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MalaCards based summary: Critical Limb Ischemia, also known as CLI, is related to atherosclerosis and limb ischemia. An important gene associated with Critical Limb Ischemia is MIR16-1 (microRNA 16-1), and among its related pathways are Tyrosine Kinases / Adaptors and Cell surface interactions at the vascular wall. The compounds gamma-carboxyglutamic acid and warfarin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Critical Limb Ischemia

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Critical Limb Ischemia, Aliases & Descriptions:

Name: Critical Limb Ischemia 30 44 62
 
Cli 44


Related Diseases for Critical Limb Ischemia

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Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to critical limb ischemia

Symptoms for Critical Limb Ischemia

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Drugs & Therapeutics for Critical Limb Ischemia

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Drug clinical trials:

Search ClinicalTrials for Critical Limb Ischemia

Search NIH Clinical Center for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous angiogenic cell precursors for the treatment of critical limb ischemia
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 9020076, 23192920, 22163120
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC), PMIDs: 15995108, 19896796, 18351022
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells, PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMIDs: 23586040, 17394441
Bone marrow-derived mononuclear cells (family), PMID: 21216483
Bone marrow-derived mesenchymal stem cells , PMID: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells , PMIDs: 18005405, 18713449, 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T), PMIDs: 22453769, 22776246, 21684715
Bone marrow-derived mononuclear cells, PMID: 21586448
Bone marrow-derived mesenchymal stem cells, PMID: 21586448
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX), PMIDs: 18154467, 19526389, 19478280
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMIDs: 23307180, 18720444, 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

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Anatomical Context for Critical Limb Ischemia

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MalaCards organs/tissues related to Critical Limb Ischemia:

32
Bone, Bone marrow, Endothelial, Monocytes, Skin, Neutrophil, Spinal cord, Brain

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
3 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Critical Limb Ischemia or affiliated genes

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MGI Mouse Phenotypes related to Critical Limb Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0AXL, CD40, GAS6, ANGPT2
2MP:00053767.2AXL, CD40, GAS6, ANGPT2, APOM

Publications for Critical Limb Ischemia

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Articles related to Critical Limb Ischemia:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Three-year clinical outcome after infrapopliteal angioplasty for critical limb ischemia in hemodialysis patients with minor or major tissue loss. (25256632)
2014
2
Endoscopic versus open saphenous vein graft harvest for lower extremity bypass in critical limb ischemia. (24370082)
2014
3
Comparison of graft patency, limb salvage, and antithrombotic therapy between prosthetic and autogenous below-knee bypass for critical limb ischemia. (24011814)
2013
4
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
5
Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: techniques and short-term follow-up. (23404942)
2013
6
Association Between Statin Medications and Mortality, Major Adverse Cardiovascular Event, and Amputation-Free Survival Rates in Patients with Critical Limb Ischemia. (24315911)
2013
7
Prognosis of critical limb ischemia in hemodialysis patients after isolated infrapopliteal balloon angioplasty: results from the Japan below-the-knee artery treatment (J-BEAT) registry. (23391091)
2013
8
Safety and efficacy of autologous cell therapy in critical limb ischemia: a systematic review. (22490340)
2013
9
Optimal medical therapy predicts amputation-free survival in chronic critical limb ischemia. (23993439)
2013
10
Combined arterial reconstruction and free tissue transfer for patients with critical limb ischemia. (24386019)
2013
11
Treatment of Chronic SFA In-Stent Occlusion With Combined Laser Atherectomy and Drug-Eluting Balloon Angioplasty in Patients With Critical Limb Ischemia: A Single-Center, Prospective, Randomized Study. (24325697)
2013
12
Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization. (24169097)
2013
13
Paradoxical impairment of angiogenesis, endothelial function and circulating number of endothelial progenitor cells in DPP4-deficient rat after critical limb ischemia. (23517567)
2013
14
Clinically-driven need for secondary interventions after endovascular revascularization of tibial arteries in patients with critical limb ischemia. (24093325)
2013
15
Intra-arterial autologous bone marrow cell transplantation in a patient with upper-extremity critical limb ischemia. (22580683)
2013
16
Effect of sarpogrelate treatment on the prognosis after endovascular therapy for critical limb ischemia. (23494607)
2013
17
Stem cell therapy for critical limb ischemia: what can we learn from cell therapy for chronic wounds? (23086986)
2012
18
Percutaneous transluminal angioplasty improves glucose control and quality of life in patients with critical limb ischemia. (23280023)
2012
19
Improved amputation-free survival in unreconstructable critical limb ischemia and its implications for clinical trial design and quality measurement. (22209608)
2012
20
Insights into gene therapy for critical limb ischemia: the devil is in the details. (22580542)
2012
21
Randomized comparison of everolimus-eluting versus bare-metal stents in patients with critical limb ischemia and infrapopliteal arterial occlusive disease. (22169682)
2012
22
Revascularization by angioplasty of type D femoropopliteal and long infrapopliteal lesion in diabetic patients with critical limb ischemia: are TASC II recommendations suitable? A population-based cohort study. (23089965)
2012
23
Hybrid procedures as a novel technique in the treatment of critical limb ischemia. (22623443)
2012
24
Comparison of clinical outcome of infrapopliteal angioplasty between Korean diabetic and non-diabetic patients with critical limb ischemia. (22112858)
2012
25
Critical limb ischemia: advanced medical therapy. (23342181)
2012
26
Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis. (21468429)
2011
27
Endovascular management of patients with critical limb ischemia. (21211929)
2011
28
Interim analysis results from the RESTORE-CLI, a randomized, double-blind multicenter phase II trial comparing expanded autologous bone marrow-derived tissue repair cells and placebo in patients with critical limb ischemia. (21684715)
2011
29
Predictors of wound complications following major amputation for critical limb ischemia. (21840153)
2011
30
Primary everolimus-eluting stenting versus balloon angioplasty with bailout bare metal stenting of long infrapopliteal lesions for treatment of critical limb ischemia. (21314342)
2011
31
Critical limb ischemia. (22009625)
2011
32
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
33
Open versus endovascular intervention for critical limb ischemia: a population-based study. (20421003)
2010
34
Use of the Boomerang catalyst advantage closure device to facilitate complex multistaged percutaneous revascularization procedures for the treatment of critical limb ischemia. (19530181)
2009
35
A direct thrombin inhibitor, lepirudin, for thrombophilic patients with inoperable critical limb ischemia. (19155057)
2009
36
Validation of the PIII CLI risk score for the prediction of amputation-free survival in patients undergoing infrainguinal autogenous vein bypass for critical limb ischemia. (19628361)
2009
37
Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia. (19747609)
2009
38
Infrapopliteal stenting with silicon carbide-coated stents in critical limb ischemia: a 12 month follow-up study. (20077948)
2009
39
Tibial intervention for critical limb ischemia. (21326541)
2009
40
Questioning the life-saving role of statins in patients with critical limb ischemia. (18796452)
2008
41
Individual treatment strategies for patients suffering from critical limb ischemia are mandatory. (17390300)
2007
42
Subintimal angioplasty as the first-choice revascularization technique for infrainguinal arterial occlusions in patients with critical limb ischemia. (17980800)
2007
43
Cardiac troponins as a risk stratification tool for patients with chronic critical limb ischemia. (17292643)
2007
44
Impact of femoropopliteal bypass surgery on the survival and amputation rate of end-stage renal disease patients with critical limb ischemia. (17323017)
2007
45
Predictive values of transcutaneous oxygen tension for above-the-ankle amputation in diabetic patients with critical limb ischemia. (17296318)
2007
46
Influence of secondary infection on amputation in chronic critical limb ischemia. (17227717)
2007
47
Risk factors for development of critical limb ischemia -- a survey of diabetic vs. nondiabetic population. (17211294)
2006
48
Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial. (12866606)
2003
49
The use of below-knee percutaneous transluminal angioplasty in arterial occlusive disease causing chronic critical limb ischemia. (8781151)
1996
50
Plasma prothrombotic markers after a short- and middle term treatment with iloprost in arteriopathic patients with critical limb ischemia. (7530356)
1994

Variations for Critical Limb Ischemia

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Expression for genes affiliated with Critical Limb Ischemia

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Expression patterns in normal tissues for genes affiliated with Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for genes affiliated with Critical Limb Ischemia

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Compounds for genes affiliated with Critical Limb Ischemia

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Sources:
44Novoseek, 50PharmGKB, 24HMDB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gamma-carboxyglutamic acid449.4AXL, GAS6
2warfarin44 50 24 1112.4GAS6, AXL
3phosphatidylserine44 28 1111.3AXL, GAS6
4vegf448.4ANGPT2, GAS6, CD40
5glucose448.4CD40, ANGPT2, APOM
6ly294002448.2AXL, CD40, GAS6, ANGPT2
7wortmannin448.2ANGPT2, GAS6, CD40, AXL
8phosphatidylinositol448.1AXL, CD40, GAS6, ANGPT2
9tyrosine448.0AXL, CD40, GAS6, ANGPT2

GO Terms for genes affiliated with Critical Limb Ischemia

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Cellular components related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7AXL, CD40, APOM
2extracellular spaceGO:0056157.7AXL, CD40, GAS6, ANGPT2

Biological processes related to Critical Limb Ischemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dendritic cell apoptotic processGO:20006699.7AXL, GAS6
2positive regulation of cytokine-mediated signaling pathwayGO:0019619.7GAS6, AXL
3cellular response to interferon-alphaGO:0354579.7AXL, GAS6
4response to glucoseGO:0097499.6ANGPT2, APOM
5dendritic cell differentiationGO:0970289.6GAS6, AXL
6positive regulation of natural killer cell differentiationGO:0328259.6GAS6, AXL
7enzyme linked receptor protein signaling pathwayGO:0071679.6GAS6, AXL
8apoptotic cell clearanceGO:0432779.6AXL, GAS6
9negative regulation of interferon-gamma productionGO:0326899.6AXL, GAS6
10protein kinase B signalingGO:0434919.6GAS6, AXL
11negative regulation of tumor necrosis factor productionGO:0327209.6GAS6, AXL
12phagocytosisGO:0069099.5AXL, GAS6
13cellular response to growth factor stimulusGO:0713639.5ANGPT2, GAS6
14positive regulation of protein kinase B signalingGO:0518979.4GAS6, AXL
15cellular response to lipopolysaccharideGO:0712229.2CD40, AXL
16neuron migrationGO:0017649.2GAS6, AXL
17organ regenerationGO:0311009.2AXL, GAS6, ANGPT2
18leukocyte migrationGO:0509009.0GAS6, ANGPT2
19positive regulation of protein phosphorylationGO:0019349.0CD40, GAS6
20signal transductionGO:0071658.8AXL, GAS6, ANGPT2
21platelet activationGO:0301688.8GAS6, CD40, AXL

Molecular functions related to Critical Limb Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:0309719.3GAS6, ANGPT2
2phosphatidylserine bindingGO:0017869.0AXL, GAS6

Products for genes affiliated with Critical Limb Ischemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Critical Limb Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet