CLI
MCID: CRT049
MIFTS: 51

Critical Limb Ischemia (CLI) malady

Aliases & Classifications for Critical Limb Ischemia

Aliases & Descriptions for Critical Limb Ischemia:

Name: Critical Limb Ischemia 38 52 69
Cli 52

Summaries for Critical Limb Ischemia

MalaCards based summary : Critical Limb Ischemia, also known as cli, is related to aortic aneurysm and neuropathy. An important gene associated with Critical Limb Ischemia is HGF (Hepatocyte Growth Factor), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Aspirin and Menthol have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Critical limb ischemia (CLI), also referred to as limb threat, is an advanced stage of peripheral artery... more...

Related Diseases for Critical Limb Ischemia

Diseases related to Critical Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 aortic aneurysm 29.8 VEGFA VWF
2 neuropathy 29.6 IL6 TNF
3 intermittent claudication 11.3
4 ischemia 11.1
5 limb ischemia 11.1
6 artery disease 10.4
7 endotheliitis 10.3
8 peripheral artery disease 10.3
9 seminal vesicle acute gonorrhea 10.2 HGF VEGFA
10 craniosynostosis, type 1 10.2 IL6 VEGFA
11 vaginal endometrial stromal tumor 10.2 HGF IL6
12 cardiac tuberculosis 10.2 IL6 VEGFA
13 tooth erosion 10.2 VEGFA VWF
14 prinzmetal's variant angina 10.2 IL6 VEGFA
15 conjugate gaze palsy 10.2 IL6 VEGFA
16 cryptosporidiosis 10.2 IL6 VEGFA
17 angular blepharoconjunctivitis 10.2 IL6 VEGFA
18 multilocular clear cell renal cell carcinoma 10.2 IL6 VEGFA
19 cataract 10.2 HGF TNF
20 pyriform sinus cancer 10.2 IL6 VEGFA
21 secretory diarrhea myopathy and deafness 10.2 IL6 VWF
22 benign idiopathic neonatal seizures 10.1 TNF VEGFA
23 spastic paraplegia 1 10.1 TNF VEGFA
24 ulcerative proctitis 10.1 TNF VEGFA
25 mucopolysaccharidosis 10.1 TNF VEGFA
26 lupus erythematosus 10.1 IL6 VWF
27 mitral valve stenosis 10.1 VEGFA VWF
28 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.1 IL6 TNF
29 dyslexia 5 10.1 IL6 TNF
30 aortic atherosclerosis 10.1 IL6 TNF
31 unilateral multicystic dysplastic kidney 10.1 IL6 TNF
32 thymic neuroendocrine carcinoma 10.1 IL6 TNF
33 swine influenza 10.1 IL6 TNF
34 drug dependence 10.1 IL6 TNF
35 transient tic disorder 10.1 IL6 TNF
36 anal paget's disease 10.1 IL6 TNF
37 papilledema 10.1 IL6 TNF
38 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.1 IL6 TNF
39 aortic coarctation 10.1 IL6 TNF
40 preaxial polydactyly of fingers 10.1 IL6 TNF
41 human immunodeficiency virus infectious disease 10.1 IL6 TNF
42 esophagus lymphoma 10.1 IL6 TNF
43 tinea capitis 10.1 IL6 TNF
44 clostridium difficile colitis 10.1 IL6 TNF
45 measles 10.1 IL6 TNF
46 cyclosporiasis 10.1 IL6 TNF
47 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL6 TNF
48 joint disorders 10.1 IL6 TNF
49 steroid dehydrogenase deficiency dental anomalies 10.1 IL6 TNF
50 trichomalacia 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Critical Limb Ischemia:



Diseases related to Critical Limb Ischemia

Symptoms & Phenotypes for Critical Limb Ischemia

MGI Mouse Phenotypes related to Critical Limb Ischemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 HGF IL6 TEK TNF VEGFA VWF
2 hematopoietic system MP:0005397 9.63 IL6 TEK TNF VEGFA VWF HGF
3 liver/biliary system MP:0005370 9.26 HGF IL6 TNF VEGFA
4 mortality/aging MP:0010768 9.1 HGF IL6 TEK TNF VEGFA VWF

Drugs & Therapeutics for Critical Limb Ischemia

Drugs for Critical Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-78-2 2244
2
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
3
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
4
Ephedrine Approved Phase 4 299-42-3 9294
5
Norepinephrine Approved Phase 4 51-41-2 439260
6
Oxymetazoline Approved Phase 4 1491-59-4 4636
7
Phenylephrine Approved Phase 4 59-42-7 6041
8
Pseudoephedrine Approved Phase 4 90-82-4 7028
9
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3 33069-62-4 36314
10
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
11
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
12
Cilostazol Approved Phase 4,Phase 2 73963-72-1 2754
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
14
Vorapaxar Approved Phase 4 618385-01-6
15
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
16
Clopidogrel Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 120202-66-6, 113665-84-2 60606
17 Analgesics Phase 4,Phase 2,Phase 3
18 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
19 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
20 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
21 Antipyretics Phase 4,Phase 2,Phase 3
22 Antirheumatic Agents Phase 4,Phase 2,Phase 3
23 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3
24 Fibrinolytic Agents Phase 4,Phase 2,Phase 3
25 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
26 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
27 Anti-Anxiety Agents Phase 4
28 Anticonvulsants Phase 4
29 calcium channel blockers Phase 4
30 Calcium, Dietary Phase 4
31 Central Nervous System Depressants Phase 4
32 Psychotropic Drugs Phase 4
33 Tranquilizing Agents Phase 4
34 Anticoagulants Phase 4,Phase 2,Phase 3
35 Antimetabolites Phase 4
36 Blood Substitutes Phase 4,Phase 2
37 Glucuronyl glucosamine glycan sulfate Phase 4
38 Hypoglycemic Agents Phase 4
39 Hypolipidemic Agents Phase 4
40 Lipid Regulating Agents Phase 4
41 Adrenergic Agents Phase 4
42 Adrenergic Agonists Phase 4
43 Adrenergic alpha-Agonists Phase 4
44 Autonomic Agents Phase 4,Phase 2
45 Mydriatics Phase 4
46 Nasal Decongestants Phase 4
47 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Protective Agents Phase 4
49 Respiratory System Agents Phase 4
50 Vasoconstrictor Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 254)
id Name Status NCT ID Phase
1 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
2 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
3 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
4 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Unknown status NCT00403780 Phase 4
5 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
6 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
7 A Pilot Trial of Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Unknown status NCT02203630 Phase 4
8 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
9 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
10 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
11 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
12 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4
13 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
14 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
15 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
16 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
17 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
18 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
19 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
20 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4
21 Drug Eluting Stent for the Management of PERipheral Arterial Disease Of the SFA (DESPERADO-SFA Study) Recruiting NCT02734836 Phase 4
22 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Active, not recruiting NCT01983449 Phase 4
23 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4
24 Vorapaxar and Lower Extremity Bypass Grafts Not yet recruiting NCT02975583 Phase 4
25 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
26 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
27 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3
28 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
29 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
30 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
31 Aspirin for the Prevention of Recurrent Venous Thromboembolism Unknown status NCT00222677 Phase 2, Phase 3
32 Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI) Completed NCT01245335 Phase 3
33 An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Completed NCT01483898 Phase 3
34 Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions Completed NCT00566657 Phase 3
35 Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA) Completed NCT02454231 Phase 2, Phase 3
36 Bone Marrow Autograft in Limb Ischemia Completed NCT00904501 Phase 3
37 Drug Eluting Stents In The Critically Ischemic Lower Leg 2 Completed NCT01442636 Phase 2, Phase 3
38 Single Arm Study With a Nitinol Self-Expanding Paclitaxel-Eluting Stent to Treat BTK Arteries Completed NCT01630070 Phase 2, Phase 3
39 Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures Completed NCT00041925 Phase 2, Phase 3
40 Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease Completed NCT00059657 Phase 3
41 Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells Recruiting NCT01833585 Phase 3
42 Efficacy, Tolerability and Safety of Intramuscular Injections of PLX PAD for the Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization Recruiting NCT03006770 Phase 3
43 Use of Indocyanine Green Angiography in Critical Limb Ischemia Recruiting NCT02820467 Phase 3
44 An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) Recruiting NCT02856230 Phase 2, Phase 3
45 Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia Recruiting NCT02230527 Phase 2, Phase 3
46 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM Recruiting NCT03174522 Phase 3
47 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM Recruiting NCT03111238 Phase 3
48 Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery Recruiting NCT01450722 Phase 3
49 PTA and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia Active, not recruiting NCT00471289 Phase 2, Phase 3
50 Safety and Efficacy Study of Autologous Bone Marrow Aspirate Concentrate for No-Option Critical Limb Ischemia Active, not recruiting NCT01818310 Phase 2, Phase 3

Search NIH Clinical Center for Critical Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Critical Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Critical Limb Ischemia:
ACP-01, autologous angiogenic precursor cells for critical limb ischemia
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for critical limb ischemia
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
PDA002, Placenta-derived cells for vascular disease
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
ReN009, human neural stem cells for peripheral arterial disease
RNL-Astrostem
StempeucelCLI
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Critical Limb Ischemia:
Angiogenic cell precursors
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 9020076 23192920 22163120
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Bone marrow-derived mononuclear cells (family) PMIDs: 23586040 17394441 21216483
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC) PMIDs: 15995108 22019148 19500466 19896796 18351022
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells PMIDs: 23586040 17394441
Bone marrow-derived mesenchymal stem cells PMIDs: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells PMIDs: 18005405 18713449 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T) PMIDs: 22453769 22776246 21684715
Bone marrow-derived mononuclear cells PMIDs: 21586448
Bone marrow-derived mesenchymal stem cells PMIDs: 21586448
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Placenta-derived cells
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX) PMIDs: 18154467 19526389 19478280
Neural stem cell line (CTX0E03) PMIDs: 23067568
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 23307180 18720444 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Critical Limb Ischemia

Anatomical Context for Critical Limb Ischemia

MalaCards organs/tissues related to Critical Limb Ischemia:

39
Bone, Endothelial, Bone Marrow, Smooth Muscle, Monocytes, Neutrophil, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Critical Limb Ischemia:
id Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
3 Placenta Chorionic Villus Chorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Critical Limb Ischemia

Articles related to Critical Limb Ischemia:

(show top 50) (show all 637)
id Title Authors Year
1
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products. ( 27914820 )
2017
2
Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia. ( 28042626 )
2017
3
Long-Term Outcomes of Successful Endovascular Therapy Via the Retrograde Approach for Below-the-Knee Chronic Total Occlusion in Patients With Critical Limb Ischemia After a Failed Antegrade Approach. ( 28045669 )
2017
4
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
5
Quality of life assessment as an outcomes measure in critical limb ischemia. ( 27876523 )
2016
6
Early-phase wound healing and long-term outcomes of a selective endovascular-first approach for treating Rutherford 5 critical limb ischemia with infrainguinal lesions. ( 27091136 )
2016
7
Treatment of Infrapopliteal Disease in Critical Limb Ischemia: Beyond Angioplasty. ( 27162221 )
2016
8
TCT-18 Validation of Wound, Ischemia, foot Ischemia (WIFI) classification system in Japanese patients after endovascular treatment for critical limb ischemia (CLI). ( 27970366 )
2016
9
Validation of the Wound, Ischemia, foot Infection (WIfI) classification system in nondiabetic patients treated by endovascular means for critical limb ischemia. ( 26994958 )
2016
10
Below-knee endovascular interventions have better outcomes compared to open bypass for patients with critical limb ischemia. ( 27928034 )
2016
11
Augmentation of arterial blood velocity with electrostimulation in patients with critical limb ischemia unsuitable for revascularization. ( 27154976 )
2016
12
Vascular access in critical limb ischemia. ( 27157294 )
2016
13
Dementia in patients suffering from critical limb ischemia. ( 27575308 )
2016
14
Safety and efficacy of cell-based therapy on critical limb ischemia: A meta-analysis. ( 27067609 )
2016
15
Long-term survival of patients with critical limb ischemia treated with iloprost: response rate and predictive criteria. A retrospective analysis of 102 patients. ( 28051243 )
2016
16
Peripheral vascular intervention is better than tibial bypass for critical limb ischemia. ( 27940922 )
2016
17
New devices to cross chronic total occlusion in critical limb ischemia. ( 27647338 )
2016
18
Human Stem Cells Overexpressing miR-21 Promote Angiogenesis in Critical Limb Ischemia by Targeting CHIP to Enhance HIF-1I+ Activity. ( 26841045 )
2016
19
Risk of contrast induced nephropathy in diabetic patients affected by critical limb ischemia and diabetic foot ulcers treated by percutaneous transluminal angioplasty of lower limbs. ( 27786404 )
2016
20
Arteriographic Patterns of Atherosclerosis and the Association between Diabetes Mellitus and Ethnicity in Chronic Critical Limb Ischemia. ( 27908824 )
2016
21
Autologous bone marrow mononuclear cell therapy for critical limb ischemia is effective and durable. ( 27021379 )
2016
22
Acute and chronic anemia and short- and long-term outcome of patients with peripheral arterial disease and critical limb ischemia. ( 27021473 )
2016
23
Monitoring of Foot Oxygenation with Near-infrared Spectroscopy in Patients with Critical Limb Ischemia Undergoing Percutaneous Transluminal Angioplasty: A Pilot Study. ( 27614555 )
2016
24
Commentary on 'Monitoring of Foot Oxygenation with Near-infrared Spectroscopy in Patients with Critical Limb Ischemia Undergoing Percutaneous Transluminal Angioplasty: A Pilot Study'. ( 27641489 )
2016
25
Endovascular Therapy Versus Bypass Surgery as First-Line Treatment Strategies for Critical Limb Ischemia: Results of the Interim Analysis of the CRITISCH Registry. ( 28007205 )
2016
26
Drug-Eluting Balloon Angioplasty for Below the Knee Lesions in End Stage Renal Disease Patients with Critical Limb Ischemia: Midterm Results. ( 27910185 )
2016
27
The Current State of Critical Limb Ischemia: A Systematic Review. ( 27551978 )
2016
28
Medical Therapy in Peripheral Artery Disease and Critical Limb Ischemia. ( 27181397 )
2016
29
Hospital Readmissions Following Endovascular Therapy for Critical Limb Ischemia: Associations With Wound Healing, Major Adverse Limb Events, and Mortality. ( 27207964 )
2016
30
The expression profile of angiogenic genes in critical limb ischemia popliteal arteries. ( 27511996 )
2016
31
Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia. ( 27526702 )
2016
32
TCT-792 Non-Invasive Hemodynamics Poorly Predict Disease Severity and Response to Endovascular Therapy in Patients with Critical Limb Ischemia. ( 27970180 )
2016
33
Characteristics of responders to autologous bone marrow cell therapy for no-option critical limb ischemia. ( 27530339 )
2016
34
The Impact of Chronic Kidney Disease on Hospitalized Patients With Peripheral Arterial Disease and Critical Limb Ischemia. ( 27069108 )
2016
35
How to Treat Critical Limb Ischemia: The Critical Need for High-Grade Evidence. ( 28007206 )
2016
36
Endovascular Treatment of Acute Aortic Occlusion with Critical Limb Ischemia using an Angiojet device. ( 27522976 )
2016
37
New treatment possibilities for patients with advanced coronary artery disease and critical limb ischemia - a feasibility study. ( 27980553 )
2016
38
2014 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report. ( 28018516 )
2016
39
Outcomes of Critical Limb Ischemia in an Urban, Safety Net Hospital Population with High WIfI Amputation Scores. ( 27546850 )
2016
40
Profunda Femoral to Anterior Tibial Artery Bypass to Treat Critical Limb Ischemia in a Patient with Numerous Prior Arterial Reconstructions. ( 27592736 )
2016
41
Using the diamond intermediate anastomosis in composite sequential bypass grafting for critical limb ischemia. ( 27016861 )
2016
42
Activation of the Pro-Oxidant PKCI^II-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia. ( 27600065 )
2016
43
Compared to Intermittant Claudication Critical Limb Ischemia Is Associated with Elevated Levels of Cytokines. ( 27611073 )
2016
44
Outcome for Endovascular and Open Procedures in Infrapopliteal Lesions for Critical Limb Ischemia: Registry Based Single Center Study. ( 27592734 )
2016
45
The Mid-Term Clinical Follow-Up Using Drug-Eluting Balloons on Tibial Artery "De Novo" Lesions in Patients With Critical Limb Ischemia: A Cohort Study. ( 27206745 )
2016
46
Successful carbon dioxide angiography guided endovascular thrombectomy of the superficial femoral artery in a young patient with critical limb ischemia. ( 27663555 )
2016
47
Nationwide Trends of Hospital Admission and Outcomes Among Critical Limb Ischemia Patients: From 2003-2011. ( 27012780 )
2016
48
Diabetes Mellitus Is Associated With Decreased Limb Survival in Patients With Critical Limb Ischemia: Pooled Data From Two Randomized Controlled Trials. ( 27612499 )
2016
49
2013 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report. ( 28018515 )
2016
50
Outcomes of Open and Endovascular Lower Extremity Revascularization in Current Smokers With Intermittent Claudication and Critical Limb Ischemia. ( 27763293 )
2016

Variations for Critical Limb Ischemia

Expression for Critical Limb Ischemia

Search GEO for disease gene expression data for Critical Limb Ischemia.

Pathways for Critical Limb Ischemia

Pathways related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 HGF IL6 TEK TNF VEGFA VWF
2
Show member pathways
13.68 HGF IL6 TEK TNF VEGFA VWF
3
Show member pathways
13.36 HGF IL6 TEK TNF VEGFA
4
Show member pathways
13.23 HGF IL6 TEK TNF VEGFA
5
Show member pathways
13.17 HGF TEK TNF VEGFA VWF
6
Show member pathways
13.07 HGF TEK VEGFA VWF
7
Show member pathways
13.04 HGF IL6 TEK TNF
8
Show member pathways
12.92 HGF IL6 TEK TNF VEGFA
9
Show member pathways
12.84 HGF IL6 TEK TNF VEGFA VWF
10 12.45 HGF IL6 VEGFA
11
Show member pathways
12.36 IL6 TEK TNF
12 12.07 HGF TNF VEGFA
13 11.94 IL6 TNF VEGFA
14 11.92 IL6 TNF VEGFA
15 11.89 HGF IL6 TEK VEGFA VWF
16 11.83 HGF IL6 VEGFA
17 11.68 IL6 TNF VEGFA
18 11.67 IL6 TEK VEGFA
19 11.57 HGF TEK VWF
20 11.51 HGF IL6 TNF VEGFA
21 11.42 IL6 TNF
22 11.41 HGF IL6 TNF
23 11.38 IL6 VEGFA
24 11.38 IL6 TNF
25
Show member pathways
11.38 IL6 TNF VEGFA
26 11.36 IL6 TNF
27 11.34 IL6 TNF
28 11.34 TNF VEGFA
29 11.3 IL6 TNF
30
Show member pathways
11.27 HGF VEGFA
31 11.23 HGF IL6 TNF
32 11.19 IL6 TNF
33 11.18 IL6 TNF
34 11.18 HGF IL6 VEGFA
35 11.14 IL6 TNF
36 11.12 IL6 TNF
37 11.09 IL6 TNF
38 10.99 TEK VEGFA
39 10.98 HGF IL6 TNF
40 10.93 IL6 TNF
41 10.88 IL6 TEK TNF VEGFA
42 10.85 IL6 TNF

GO Terms for Critical Limb Ischemia

Cellular components related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 HGF IL6 TEK TNF VEGFA VWF
2 platelet alpha granule lumen GO:0031093 8.8 HGF VEGFA VWF

Biological processes related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.89 HGF IL6 TNF VEGFA
2 positive regulation of gene expression GO:0010628 9.79 IL6 TNF VEGFA
3 negative regulation of apoptotic process GO:0043066 9.76 HGF IL6 TEK VEGFA
4 MAPK cascade GO:0000165 9.74 HGF TEK TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 IL6 TEK TNF
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 IL6 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.65 TEK TNF VEGFA
8 positive regulation of MAP kinase activity GO:0043406 9.64 TNF VEGFA
9 humoral immune response GO:0006959 9.64 IL6 TNF
10 positive regulation of osteoblast differentiation GO:0045669 9.63 HGF IL6
11 positive regulation of cell adhesion GO:0045785 9.63 TNF VEGFA
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 IL6 VEGFA
13 positive regulation of endothelial cell migration GO:0010595 9.61 TEK VEGFA
14 negative regulation of fat cell differentiation GO:0045599 9.61 IL6 TNF
15 platelet degranulation GO:0002576 9.61 HGF VEGFA VWF
16 positive regulation of interleukin-6 production GO:0032755 9.6 IL6 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL6 TNF
18 positive chemotaxis GO:0050918 9.58 HGF VEGFA
19 negative regulation of interleukin-6 production GO:0032715 9.56 HGF TNF
20 positive regulation of protein complex assembly GO:0031334 9.55 TNF VEGFA
21 positive regulation of focal adhesion assembly GO:0051894 9.54 TEK VEGFA
22 positive regulation of angiogenesis GO:0045766 9.54 HGF TEK VEGFA
23 positive regulation of chemokine production GO:0032722 9.51 IL6 TNF
24 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 HGF IL6 VEGFA
25 cellular response to hepatocyte growth factor stimulus GO:0035729 9.49 HGF IL6
26 negative regulation of lipid storage GO:0010888 9.4 IL6 TNF
27 positive regulation of protein kinase B signaling GO:0051897 9.33 IL6 TEK TNF
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.26 IL6 TNF
29 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.13 IL6 TNF VEGFA
30 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 8.8 HGF IL6 VEGFA

Molecular functions related to Critical Limb Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 HGF VEGFA
2 cytokine activity GO:0005125 9.13 IL6 TNF VEGFA
3 growth factor activity GO:0008083 8.8 HGF IL6 VEGFA

Sources for Critical Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....