MCID: CRH004
MIFTS: 21

Crohn Disease-Associated Growth Failure malady

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Summaries for Crohn Disease-Associated Growth Failure

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47OMIM, 33MalaCards
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MalaCards: Crohn Disease-Associated Growth Failure is related to arteriosclerosis and kaposi's sarcoma. An important gene associated with Crohn Disease-Associated Growth Failure is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder.

Description from OMIM:47 266600

Aliases & Classifications for Crohn Disease-Associated Growth Failure

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47OMIM
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Aliases & Descriptions:

crohn disease-associated growth failure 47


Related Diseases for Crohn Disease-Associated Growth Failure

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17GeneCards, 18GeneDecks
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Diseases related to Crohn Disease-Associated Growth Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis10.1HGF
2kaposi's sarcoma10.0IL6
3diabetes mellitus10.0IL6
4endometriosis10.0HGF, IL6
5chronic kidney failure10.0HGF, IL6
6myeloma10.0HGF, IL6
7hepatocellular carcinoma10.0IL6, HGF
8primary hyperoxaluria10.0HGF, IL6

Graphical network of diseases related to Crohn Disease-Associated Growth Failure:



Diseases related to crohn disease-associated growth failure

Symptoms for Crohn Disease-Associated Growth Failure

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47OMIM
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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

Drugs & Therapeutics for Crohn Disease-Associated Growth Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Crohn Disease-Associated Growth Failure

Search NIH Clinical Center for Crohn Disease-Associated Growth Failure

Genetic Tests for Crohn Disease-Associated Growth Failure

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Anatomical Context for Crohn Disease-Associated Growth Failure

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Animal Models for Crohn Disease-Associated Growth Failure or affiliated genes

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Publications for Crohn Disease-Associated Growth Failure

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Variations for Crohn Disease-Associated Growth Failure

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Expression for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crohn Disease-Associated Growth Failure

Search GEO for disease gene expression data for Crohn Disease-Associated Growth Failure.

Pathways for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
61Tocris Bioscience, 45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752619.6HGF, IL6
2pf 04217903 mesylate619.6IL6, HGF
3su 11274619.6IL6, HGF
4rebamipide459.6HGF, IL6
5filgrastim45 1110.5IL6, HGF
6crizotinib61 5110.5IL6, HGF
7pmma459.5HGF, IL6
8dextran sulfate459.5IL6, HGF
9pdtc459.5HGF, IL6
10pge1459.5HGF, IL6
11aprotinin45 1110.5IL6, HGF
12thalidomide45 51 61 1112.5HGF, IL6
13sp 60012545 6110.5HGF, IL6
14prednisolone45 29 1111.5IL6, HGF
15hydrocortisone45 3 61 1112.5HGF, IL6
16tgf beta1459.5IL6, HGF
17herbimycin a45 6110.5HGF, IL6
18hyaluronic acid45 2410.5HGF, IL6
19methotrexate51 45 1111.5IL6, HGF
20n acetylcysteine459.5HGF, IL6
21indomethacin45 29 61 1112.5IL6, HGF
22sb 20358045 6110.5HGF, IL6
23vitamin d459.5HGF, IL6
24norepinephrine45 24 1111.5IL6, HGF
25histamine45 29 2411.4HGF, IL6
26pd 98,059459.4IL6, HGF
27ly294002459.4HGF, IL6
28actinomycin d459.4HGF, IL6
29genistein45 29 61 3 24 1114.4IL6, HGF
30cyclosporin a45 29 6111.4HGF, IL6
31pge2459.4IL6, HGF
32lactate459.4HGF, IL6
33thymidine45 2410.3HGF, IL6
34creatinine459.3IL6, HGF
35cycloheximide459.3HGF, IL6
36testosterone45 61 24 1112.2IL6, HGF
37dexamethasone45 51 29 1112.2HGF, IL6
38vegf459.1HGF, IL6
39retinoic acid45 2410.1HGF, IL6
40alanine459.0IL6, HGF
41estrogen458.8HGF, IL6

GO Terms for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
16Gene Ontology
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Biological processes related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, IL6
5platelet activationGO:0301689.0IL6, HGF
6negative regulation of apoptotic processGO:0430668.8HGF, IL6

Molecular functions related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1HGF, IL6

Products for genes affiliated with Crohn Disease-Associated Growth Failure

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Crohn Disease-Associated Growth Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet