MCID: CRH004
MIFTS: 21

Crohn Disease-Associated Growth Failure malady

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Summaries for Crohn Disease-Associated Growth Failure

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MalaCards based summary: Crohn Disease-Associated Growth Failure is related to arteriosclerosis and kaposi's sarcoma, and has symptoms including An important gene associated with Crohn Disease-Associated Growth Failure is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder.

Description from OMIM:46 266600

Aliases & Classifications for Crohn Disease-Associated Growth Failure

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Crohn Disease-Associated Growth Failure, Aliases & Descriptions:

Name: Crohn Disease-Associated Growth Failure 46


Related Diseases for Crohn Disease-Associated Growth Failure

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Diseases related to Crohn Disease-Associated Growth Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis10.3HGF
2kaposi's sarcoma10.2IL6
3diabetes mellitus10.0IL6
4endometriosis9.9HGF, IL6
5chronic kidney failure9.9IL6, HGF
6myeloma9.9HGF, IL6
7liver cancer9.9HGF, IL6
8primary hyperoxaluria9.8HGF, IL6

Graphical network of diseases related to Crohn Disease-Associated Growth Failure:



Diseases related to crohn disease-associated growth failure

Symptoms for Crohn Disease-Associated Growth Failure

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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

HPO human phenotypes related to Crohn Disease-Associated Growth Failure:

(show all 7)
id Description Frequency HPO Source Accession
1 heterogeneous HP:0001425
2 multifactorial inheritance HP:0001426
3 weight loss HP:0001824
4 diarrhea HP:0002014
5 abdominal pain HP:0002027
6 intestinal obstruction HP:0005214
7 recurrent aphthous stomatitis HP:0011107

Drugs & Therapeutics for Crohn Disease-Associated Growth Failure

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Drug clinical trials:

Search ClinicalTrials for Crohn Disease-Associated Growth Failure

Search NIH Clinical Center for Crohn Disease-Associated Growth Failure

Genetic Tests for Crohn Disease-Associated Growth Failure

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Anatomical Context for Crohn Disease-Associated Growth Failure

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Animal Models for Crohn Disease-Associated Growth Failure or affiliated genes

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Publications for Crohn Disease-Associated Growth Failure

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Variations for Crohn Disease-Associated Growth Failure

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Expression for genes affiliated with Crohn Disease-Associated Growth Failure

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Expression patterns in normal tissues for genes affiliated with Crohn Disease-Associated Growth Failure

Search GEO for disease gene expression data for Crohn Disease-Associated Growth Failure.

Pathways for genes affiliated with Crohn Disease-Associated Growth Failure

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Pathways related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Crohn Disease-Associated Growth Failure

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Compounds related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752619.6HGF, IL6
2pf 04217903 mesylate619.6IL6, HGF
3su 11274619.6IL6, HGF
4rebamipide449.6HGF, IL6
5filgrastim44 1110.5IL6, HGF
6crizotinib61 5010.5IL6, HGF
7pmma449.5HGF, IL6
8dextran sulfate449.5IL6, HGF
9pdtc449.5HGF, IL6
10pge1449.5HGF, IL6
11aprotinin44 1110.5IL6, HGF
12thalidomide44 50 61 1112.5HGF, IL6
13sp 60012544 6110.5HGF, IL6
14prednisolone44 28 1111.5IL6, HGF
15hydrocortisone44 2 61 1112.5HGF, IL6
16tgf beta1449.5IL6, HGF
17herbimycin a44 6110.5HGF, IL6
18hyaluronic acid44 2410.5HGF, IL6
19methotrexate50 44 1111.5IL6, HGF
20n acetylcysteine449.5HGF, IL6
21indomethacin44 28 61 1112.5IL6, HGF
22sb 20358044 6110.5HGF, IL6
23vitamin d449.5HGF, IL6
24norepinephrine44 24 1111.5IL6, HGF
25histamine44 28 2411.4HGF, IL6
26pd 98,059449.4IL6, HGF
27ly294002449.4HGF, IL6
28actinomycin d449.4HGF, IL6
29genistein44 28 61 2 24 1114.4IL6, HGF
30cyclosporin a44 28 6111.4HGF, IL6
31pge2449.4IL6, HGF
32lactate449.4HGF, IL6
33thymidine44 2410.3HGF, IL6
34creatinine449.3IL6, HGF
35cycloheximide449.3HGF, IL6
36testosterone44 61 24 1112.2IL6, HGF
37dexamethasone44 50 28 1112.2HGF, IL6
38vegf449.1HGF, IL6
39retinoic acid44 2410.1HGF, IL6
40alanine449.0IL6, HGF
41estrogen448.8HGF, IL6

GO Terms for genes affiliated with Crohn Disease-Associated Growth Failure

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Biological processes related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, IL6
5platelet activationGO:0301689.0IL6, HGF
6negative regulation of apoptotic processGO:0430668.8IL6, HGF

Molecular functions related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1HGF, IL6

Products for genes affiliated with Crohn Disease-Associated Growth Failure

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  • Antibodies
  • Proteins
  • Lysates

Sources for Crohn Disease-Associated Growth Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet