MCID: CRH004
MIFTS: 21

Crohn Disease-Associated Growth Failure malady

Summaries for Crohn Disease-Associated Growth Failure

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Sources:
48OMIM, 34MalaCards
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MalaCards: Crohn Disease-Associated Growth Failure is related to arteriosclerosis and kaposi's sarcoma. An important gene associated with Crohn Disease-Associated Growth Failure is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder.

Description from OMIM:48 266600

Aliases & Classifications for Crohn Disease-Associated Growth Failure

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48OMIM
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Aliases & Descriptions:

crohn disease-associated growth failure 48


Related Diseases for Crohn Disease-Associated Growth Failure

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Crohn Disease-Associated Growth Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis10.1HGF
2kaposi's sarcoma10.0IL6
3diabetes mellitus10.0IL6
4endometriosis10.0HGF, IL6
5chronic kidney failure10.0HGF, IL6
6myeloma10.0HGF, IL6
7hepatocellular carcinoma10.0IL6, HGF
8primary hyperoxaluria10.0HGF, IL6

Graphical network of diseases related to Crohn Disease-Associated Growth Failure:



Diseases related to crohn disease-associated growth failure

Symptoms for Crohn Disease-Associated Growth Failure

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48OMIM
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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

Drugs & Therapeutics for Crohn Disease-Associated Growth Failure

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Crohn Disease-Associated Growth Failure

Drug clinical trials:

Search ClinicalTrials for Crohn Disease-Associated Growth Failure

Search NIH Clinical Center for Crohn Disease-Associated Growth Failure

Search CenterWatch for Crohn Disease-Associated Growth Failure

Genetic Tests for Crohn Disease-Associated Growth Failure

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Anatomical Context for Crohn Disease-Associated Growth Failure

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Animal Models for Crohn Disease-Associated Growth Failure or affiliated genes

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Publications for Crohn Disease-Associated Growth Failure

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Variations for Crohn Disease-Associated Growth Failure

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Expression for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crohn Disease-Associated Growth Failure

Search GEO for disease gene expression data for Crohn Disease-Associated Growth Failure.

Pathways for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 56Reactome
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Pathways related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
62Tocris Bioscience, 46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752629.6HGF, IL6
2pf 04217903 mesylate629.6IL6, HGF
3su 11274629.6IL6, HGF
4rebamipide469.6HGF, IL6
5filgrastim46 1210.5IL6, HGF
6crizotinib62 5210.5IL6, HGF
7pmma469.5HGF, IL6
8dextran sulfate469.5IL6, HGF
9pdtc469.5HGF, IL6
10pge1469.5HGF, IL6
11aprotinin46 1210.5IL6, HGF
12thalidomide46 52 62 1212.5HGF, IL6
13sp 60012546 6210.5HGF, IL6
14prednisolone46 30 1211.5IL6, HGF
15hydrocortisone46 3 62 1212.5HGF, IL6
16tgf beta1469.5IL6, HGF
17herbimycin a46 6210.5HGF, IL6
18hyaluronic acid46 2510.5HGF, IL6
19methotrexate52 46 1211.5IL6, HGF
20n acetylcysteine469.5HGF, IL6
21indomethacin46 30 62 1212.5IL6, HGF
22sb 20358046 6210.5HGF, IL6
23vitamin d469.5HGF, IL6
24norepinephrine46 25 1211.5IL6, HGF
25histamine46 30 2511.4HGF, IL6
26pd 98,059469.4IL6, HGF
27ly294002469.4HGF, IL6
28actinomycin d469.4HGF, IL6
29genistein46 30 62 3 25 1214.4IL6, HGF
30cyclosporin a46 30 6211.4HGF, IL6
31pge2469.4IL6, HGF
32lactate469.4HGF, IL6
33thymidine46 2510.3HGF, IL6
34creatinine469.3IL6, HGF
35cycloheximide469.3HGF, IL6
36testosterone46 62 25 1212.2IL6, HGF
37dexamethasone46 52 30 1212.2HGF, IL6
38vegf469.1HGF, IL6
39retinoic acid46 2510.1HGF, IL6
40alanine469.0IL6, HGF
41estrogen468.8HGF, IL6

GO Terms for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
17Gene Ontology
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Biological processes related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, IL6
5platelet activationGO:0301689.0IL6, HGF
6negative regulation of apoptotic processGO:0430668.8HGF, IL6

Molecular functions related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1HGF, IL6

Products for genes affiliated with Crohn Disease-Associated Growth Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Crohn Disease-Associated Growth Failure

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet