MCID: CRH004
MIFTS: 20

Crohn Disease-Associated Growth Failure malady

Summaries for Crohn Disease-Associated Growth Failure

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46OMIM, 32MalaCards
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MalaCards: Crohn Disease-Associated Growth Failure is related to gastric ulcer and proliferative diabetic retinopathy. An important gene associated with Crohn Disease-Associated Growth Failure is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PI3K-Akt signaling pathway and p70S6K Signaling. The compounds pha 665752 and su 11274 have been mentioned in the context of this disorder.

Description from OMIM:46 266600

Aliases & Classifications for Crohn Disease-Associated Growth Failure

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46OMIM
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Aliases & Descriptions:

crohn disease-associated growth failure 46


Related Diseases for Crohn Disease-Associated Growth Failure

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17GeneCards, 18GeneDecks
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Diseases related to Crohn Disease-Associated Growth Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1gastric ulcer10.0HGF
2proliferative diabetic retinopathy10.0HGF
3biliary atresia10.0HGF
4arteriosclerosis10.0HGF
5malignant mesothelioma10.0HGF
6hepatoblastoma10.0HGF
7pulmonary fibrosis10.0HGF
8periodontal disease10.0IL6
9acute pancreatitis10.0IL6
10liver cirrhosis10.0HGF
11meningitis10.0IL6
12vascular disease10.0IL6
13pulmonary disease, chronic obstructive10.0IL6
14chronic kidney failure10.0HGF, IL6
15primary hyperoxaluria10.0IL6, HGF

Graphical network of diseases related to Crohn Disease-Associated Growth Failure:



Diseases related to crohn disease-associated growth failure

Clinical Features for Crohn Disease-Associated Growth Failure

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46OMIM
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Clinical features from OMIM:

266600

Clinical synopsis from OMIM:

266600

Drugs & Therapeutics for Crohn Disease-Associated Growth Failure

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Crohn Disease-Associated Growth Failure

Genetic Tests for Crohn Disease-Associated Growth Failure

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Anatomical Context for Crohn Disease-Associated Growth Failure

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Animal Models for Crohn Disease-Associated Growth Failure or affiliated genes

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Publications for Crohn Disease-Associated Growth Failure

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Genetic Variations for Crohn Disease-Associated Growth Failure

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Expression for genes affiliated with Crohn Disease-Associated Growth Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crohn Disease-Associated Growth Failure

Search GEO for disease gene expression data for Crohn Disease-Associated Growth Failure.

Pathways for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1IL6, HGF
2
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9.1IL6, HGF
39.1HGF, IL6
4
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9.1IL6, HGF
5
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9.1IL6, HGF
6
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9.1IL6, HGF

Compounds for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources:
59Tocris Bioscience, 44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1pha 665752599.5IL6, HGF
2su 11274599.5IL6, HGF
3pf 04217903 mesylate599.5IL6, HGF
4rebamipide449.5HGF, IL6
5crizotinib49 5910.5HGF, IL6
6filgrastim44 1110.5IL6, HGF
7pmma449.5IL6, HGF
8dextran sulfate449.5HGF, IL6
9pdtc449.5IL6, HGF
10pge1449.5IL6, HGF
11thalidomide44 49 59 1112.5IL6, HGF
12sp 60012544 5910.4HGF, IL6
13prednisolone44 28 1111.4IL6, HGF
14tgf beta1449.4IL6, HGF
15herbimycin a44 5910.4HGF, IL6
16hyaluronic acid44 2410.4IL6, HGF
17methotrexate44 49 1111.4IL6, HGF
18n acetylcysteine449.4IL6, HGF
19indomethacin44 59 28 1112.4HGF, IL6
20sb 20358044 5910.3IL6, HGF
21vitamin d449.3IL6, HGF
22histamine44 28 2411.3HGF, IL6
23pd 98,059449.2IL6, HGF
24ly294002449.2IL6, HGF
25actinomycin d449.1HGF, IL6
26lactate449.1IL6, HGF
27genistein44 28 59 2 11 2414.0IL6, HGF
28pge2448.8IL6, HGF

GO Terms for genes affiliated with Crohn Disease-Associated Growth Failure

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16Gene Ontology
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Biological processes related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.1IL6, HGF
2platelet activationGO:0301689.1IL6, HGF
3negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.0IL6, HGF
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8IL6, HGF

Molecular functions related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1IL6, HGF

Products for genes affiliated with Crohn Disease-Associated Growth Failure

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Sources for Crohn Disease-Associated Growth Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet