MCID: CRH004
MIFTS: 23

Crohn Disease-Associated Growth Failure malady

Summaries for Crohn Disease-Associated Growth Failure

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MalaCards based summary: Crohn Disease-Associated Growth Failure is related to arteriosclerosis and kaposi's sarcoma, and has symptoms including heterogeneous, multifactorial inheritance and weight loss. An important gene associated with Crohn Disease-Associated Growth Failure is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are PAK Pathway and TGF-Beta Pathway. The compounds pha 665752 and pf 04217903 mesylate have been mentioned in the context of this disorder.

Description from OMIM:46 266600

Aliases & Classifications for Crohn Disease-Associated Growth Failure

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Crohn Disease-Associated Growth Failure, Aliases & Descriptions:

Name: Crohn Disease-Associated Growth Failure 46


Related Diseases for Crohn Disease-Associated Growth Failure

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Diseases related to Crohn Disease-Associated Growth Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis10.3HGF
2kaposi's sarcoma10.2IL6
3diabetes mellitus10.0IL6
4endometriosis9.9HGF, IL6
5chronic kidney failure9.9HGF, IL6
6myeloma9.9HGF, IL6
7liver cancer9.9IL6, HGF
8primary hyperoxaluria9.8HGF, IL6

Graphical network of diseases related to Crohn Disease-Associated Growth Failure:



Diseases related to crohn disease-associated growth failure

Symptoms for Crohn Disease-Associated Growth Failure

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Symptoms by clinical synopsis from OMIM:

266600

Clinical features from OMIM:

266600

HPO human phenotypes related to Crohn Disease-Associated Growth Failure:

(show all 7)
id Description Frequency HPO Source Accession
1 heterogeneous HP:0001425
2 multifactorial inheritance HP:0001426
3 weight loss HP:0001824
4 diarrhea HP:0002014
5 abdominal pain HP:0002027
6 intestinal obstruction HP:0005214
7 recurrent aphthous stomatitis HP:0011107

Drugs & Therapeutics for Crohn Disease-Associated Growth Failure

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Drug clinical trials:

Search ClinicalTrials for Crohn Disease-Associated Growth Failure

Search NIH Clinical Center for Crohn Disease-Associated Growth Failure

Genetic Tests for Crohn Disease-Associated Growth Failure

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Anatomical Context for Crohn Disease-Associated Growth Failure

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Animal Models for Crohn Disease-Associated Growth Failure or affiliated genes

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Publications for Crohn Disease-Associated Growth Failure

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Variations for Crohn Disease-Associated Growth Failure

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Expression for genes affiliated with Crohn Disease-Associated Growth Failure

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Expression patterns in normal tissues for genes affiliated with Crohn Disease-Associated Growth Failure

Search GEO for disease gene expression data for Crohn Disease-Associated Growth Failure.

Pathways for genes affiliated with Crohn Disease-Associated Growth Failure

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Pathways related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1IL6, HGF
2
Show member pathways
9.1HGF, IL6
3
Show member pathways
9.1HGF, IL6
4
Show member pathways
9.1IL6, HGF
5
Show member pathways
9.1HGF, IL6
6
Show member pathways
9.1HGF, IL6
7
Show member pathways
9.1HGF, IL6
8
Show member pathways
9.1IL6, HGF
9
Show member pathways
9.1IL6, HGF
10
Show member pathways
9.1HGF, IL6
11
Show member pathways
9.1HGF, IL6
12
Show member pathways
9.1HGF, IL6
139.1IL6, HGF
149.1HGF, IL6
15
Show member pathways
9.1HGF, IL6
16
Show member pathways
9.1HGF, IL6
179.1HGF, IL6

Compounds for genes affiliated with Crohn Disease-Associated Growth Failure

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Compounds related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1pha 665752609.6HGF, IL6
2pf 04217903 mesylate609.6IL6, HGF
3su 11274609.6IL6, HGF
4rebamipide449.6HGF, IL6
5filgrastim44 1210.5IL6, HGF
6crizotinib60 5010.5IL6, HGF
7pmma449.5HGF, IL6
8dextran sulfate449.5IL6, HGF
9pdtc449.5HGF, IL6
10pge1449.5HGF, IL6
11aprotinin44 1210.5IL6, HGF
12thalidomide44 50 60 1212.5HGF, IL6
13sp 60012544 6010.5HGF, IL6
14prednisolone44 29 1211.5IL6, HGF
15hydrocortisone44 3 60 1212.5HGF, IL6
16tgf beta1449.5IL6, HGF
17herbimycin a44 6010.5HGF, IL6
18hyaluronic acid44 2510.5HGF, IL6
19methotrexate50 44 1211.5IL6, HGF
20n acetylcysteine449.5HGF, IL6
21indomethacin44 29 60 1212.5IL6, HGF
22sb 20358044 6010.5HGF, IL6
23vitamin d449.5HGF, IL6
24norepinephrine44 25 1211.5IL6, HGF
25histamine44 29 2511.4HGF, IL6
26pd 98,059449.4IL6, HGF
27ly294002449.4HGF, IL6
28actinomycin d449.4HGF, IL6
29genistein44 29 60 3 25 1214.4IL6, HGF
30cyclosporin a44 29 6011.4HGF, IL6
31pge2449.4IL6, HGF
32lactate449.4HGF, IL6
33thymidine44 2510.3HGF, IL6
34creatinine449.3IL6, HGF
35cycloheximide449.3HGF, IL6
36testosterone44 60 25 1212.2IL6, HGF
37dexamethasone44 50 29 1212.2HGF, IL6
38vegf449.1HGF, IL6
39retinoic acid44 2510.1HGF, IL6
40alanine449.0IL6, HGF
41estrogen448.8HGF, IL6

GO Terms for genes affiliated with Crohn Disease-Associated Growth Failure

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Biological processes related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of osteoblast differentiationGO:0456699.2HGF, IL6
2negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.2HGF, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1HGF, IL6
4positive regulation of transcription from RNA polymerase II promoterGO:0459449.1HGF, IL6
5platelet activationGO:0301689.0IL6, HGF
6negative regulation of apoptotic processGO:0430668.8HGF, IL6

Molecular functions related to Crohn Disease-Associated Growth Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1HGF, IL6

Products for genes affiliated with Crohn Disease-Associated Growth Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Crohn Disease-Associated Growth Failure

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet