Aliases & Classifications for Crohn's Colitis

MalaCards integrated aliases for Crohn's Colitis:

Name: Crohn's Colitis 12 14
Crohn Disease 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060192
ICD10 33 K50.1
ICD9CM 35 555.1
MeSH 42 D003424
UMLS 69 C0156147

Summaries for Crohn's Colitis

Disease Ontology : 12 An inflammatory bowel disease characterized by inflammation located in colon only, has symptom diarrhea, has symptom rectal bleeding, has symptom skin lesions and has symptom formation of ulcers, fistulas and abscesses around the anus.

MalaCards based summary : Crohn's Colitis, also known as crohn disease, is related to ileitis and basidiobolomycosis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Colitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Infliximab and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and cardiovascular system

Related Diseases for Crohn's Colitis

Diseases related to Crohn's Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
id Related Disease Score Top Affiliating Genes
1 ileitis 30.3 CDH1 IL1B
2 basidiobolomycosis 30.1 CXCL8 TNF
3 pyelonephritis 29.7 CXCL8 IL1B TNF
4 colon adenocarcinoma 29.7 CXCL8 IL1B TNF
5 lymphoma 28.5 IFNG IL1B IL2 TNF
6 rheumatoid arthritis 27.5 CXCL8 IFNG IL1B IL2 TNF
7 crohn disease-associated growth failure 12.2
8 crohn's disease 11.7
9 inflammatory bowel disease 28, early onset, autosomal recessive 10.8
10 inflammatory bowel disease 17, protection against 10.8
11 inflammatory bowel disease 10 10.8
12 inflammatory bowel disease 25, early onset, autosomal recessive 10.8
13 inflammatory bowel disease 19 10.8
14 inflammatory bowel disease 13 10.8
15 inflammatory bowel disease 14 10.8
16 oculomotor nerve paralysis 10.8 CXCL8 IL1B
17 common peroneal nerve lesion 10.7 CXCL8 IL1B
18 lacrimal apparatus disease 10.7 CXCL8 IL1B
19 infancy electroclinical syndrome 10.7 CXCL8 IL1B
20 tabatznik syndrome 10.7 IL1B TNF
21 pulmonary hypertension 10.7 IL1B TNF
22 congenital insensitivity to pain with hyperhidrosis 10.7 CXCL8 NOD2
23 chancroid 10.7 CXCL8 IL1B
24 walker dyson syndrome 10.7 IL1B TNF
25 autoimmune disease 6 10.7
26 bile acid malabsorption, primary 10.7
27 short bowel syndrome 10.7
28 thiopurines, poor metabolism of, 1 10.7
29 cataract 10.7 IL1B TNF
30 scrotal carcinoma 10.7 IL1B TNF
31 acute gonococcal cystitis 10.7 CXCL8 NOD2
32 neuromuscular disease 10.6 NOD2 TNF
33 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.6 IL1B TNF
34 subglottis neoplasm 10.6 CXCL8 IL1B
35 upper gum cancer 10.6 IL1B TNF
36 tarsal tunnel syndrome 10.6 CXCL8 TNF
37 moved to 244450 10.6 IL1B TNF
38 bipolar i disorder 10.6 IL1B TNF
39 bullous retinoschisis 10.6 CXCL8 IL1B
40 halal setton wang syndrome 10.6 CXCL8 TNF
41 lung sarcoma 10.6 IL1B TNF
42 gastric cancer risk after h. pylori infection 10.6 CDH1 IL1B
43 central nervous system leiomyosarcoma 10.6 IL1B TNF
44 carbuncle 10.6 CXCL8 IL1B
45 indolent myeloma 10.6 IL1B TNF
46 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.6 IL1B TNF
47 ileocolitis 10.6 IL1B TNF
48 mycobacterium kansasii 10.6 CXCL8 TNF
49 immunodeficiency 27b, mycobacteriosis, ad 10.6 CDH1 IL1B
50 trachea sarcoma 10.5 CXCL8 TNF

Graphical network of the top 20 diseases related to Crohn's Colitis:



Diseases related to Crohn's Colitis

Symptoms & Phenotypes for Crohn's Colitis

UMLS symptoms related to Crohn's Colitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Crohn's Colitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 IL2 NOD2 NOS2 TNF CXCL8 IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 IL2 NOD2 NOS2 TNF CXCL8 IL1B

MGI Mouse Phenotypes related to Crohn's Colitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 CDH1 IFNG IL1B IL2 NOS2 SLIT2
2 digestive/alimentary MP:0005381 9.8 CDH1 IFNG IL2 NOD2 NOS2 SLIT2
3 endocrine/exocrine gland MP:0005379 9.7 CDH1 CDH3 IFNG IL2 NOS2 SLIT2
4 integument MP:0010771 9.5 IL1B NOS2 SLIT2 TNF CDH1 CDH3
5 neoplasm MP:0002006 9.1 CDH1 IFNG IL1B IL2 NOS2 TNF

Drugs & Therapeutics for Crohn's Colitis

Drugs for Crohn's Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 212)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
2
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
3
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Ciprofloxacin Approved, Investigational Phase 4,Phase 2 85721-33-1 2764
6
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
7
Iron Approved Phase 4,Phase 2 7439-89-6 23925
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
9
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
10
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
11 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 943609-66-3
12
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
13
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
14
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
15
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
16
Losartan Approved Phase 4 114798-26-4 3961
17
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
18
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
19
Benzocaine Approved Phase 4,Phase 1 1994-09-7, 94-09-7 2337
20
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
21
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 50-14-6 5280793
22
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1406-16-2
23
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
24 tannic acid Approved, Nutraceutical Phase 4,Phase 1
25
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
26 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
29 6-Mercaptopurine Phase 4,Phase 3,Phase 2
30 Adjuvants, Immunologic Phase 4,Phase 2
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
32 Mesalamine Phase 4,Phase 2,Phase 3,Early Phase 1 89-57-6
33 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
34 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
35 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
36 glucocorticoids Phase 4,Phase 2,Phase 3
37 Hormone Antagonists Phase 4,Phase 2,Phase 3
38 Hormones Phase 4,Phase 2,Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
41 Antibiotics, Antitubercular Phase 4,Phase 2
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2
43 Antimalarials Phase 4,Phase 2
44 Antiparasitic Agents Phase 4,Phase 3,Phase 2
45 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
46 Antitubercular Agents Phase 4,Phase 2
47 Autonomic Agents Phase 4,Phase 2
48 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2
49 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
50 Topoisomerase Inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 342)

id Name Status NCT ID Phase Drugs
1 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
2 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
3 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
4 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
5 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
6 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
7 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
8 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
9 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
10 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
11 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)
12 Immunogenicity of Hepatitis A Vaccine in Inflammatory Bowel Disease (IBD) Patients Completed NCT01341808 Phase 4
13 Single-dose Linaclotide for Capsule Endoscopy Preparation Completed NCT02465385 Phase 4 Linaclotide
14 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
15 Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease Completed NCT01981889 Phase 4 Prednisone
16 Manipulating the Microbiome in IBD by Antibiotics and FMT Recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
17 Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease Recruiting NCT02559713 Phase 4 Vedolizumab
18 Extended Access Program of Vedolizumab IV in Ulcerative Colitis and Crohn's Disease Recruiting NCT02743806 Phase 4 Vedolizumab
19 Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study Recruiting NCT02760615 Phase 4 Caffeine;Losartan;Omeprazole;Dextromethorphan;Midazolam;Vedolizumab
20 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Recruiting NCT01804166 Phase 4 Infliximab;Golimumab
21 Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis Not yet recruiting NCT02921555 Phase 4 Methylprednisolone;Prednisone
22 Brief Escalation of Adalimumab Treatment for Prevention of Clinical Relapse in IBD Not yet recruiting NCT03059849 Phase 4 Adalimumab
23 GIS-SUSANTI-TNF-2015 (Anti-TNF Discontinuation ) Not yet recruiting NCT02994836 Phase 4 Anti-TNF discontinuation: Physiological saline solution;Anti-TNF discontinuation: Physiological saline solution
24 Anemia in Inflammatory Bowel Disease Not yet recruiting NCT02760940 Phase 4 oral liposomal iron
25 Evaluation of Health Costs and Resource Utilization Terminated NCT01960426 Phase 4
26 Efficacy Study of Granulocytapheresis Plus Steroids vs Steroids Alone in Active Steroid Dependant Ulcerative Colitis Terminated NCT00702611 Phase 4
27 Trial of High Dose Vitamin D in Patient's With Crohn's Disease Terminated NCT02208310 Phase 4 Cholecalciferol 10,000 IU;Cholecalciferol 400 IU
28 Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease Unknown status NCT01817972 Phase 3 Azathioprine
29 Probiotics in GastroIntestinal Disorders Unknown status NCT00510978 Phase 2, Phase 3
30 Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease (IBD) Unknown status NCT01496053 Phase 2, Phase 3
31 Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases Unknown status NCT01793831 Phase 2, Phase 3 5-ASA, Prednisone, Azathioprine or Remicade
32 Standardized Fecal Microbiota Transplantation for Ulcerative Colitis Unknown status NCT01790061 Phase 2, Phase 3 Traditional treatments according to associated guidelines
33 Adalimumab for the Management of Post-operative Crohn's Disease (CD) Unknown status NCT01629628 Phase 3 Adalimumab;6 Mercaptopurine
34 Thalidomide in Pediatric Inflammatory Bowel Diseases. Completed NCT00720538 Phase 3 Thalidomide;placebo
35 A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Patients With Moderately to Severely Active Crohn's Disease (UNITI-2) Completed NCT01369342 Phase 3 Group 1: Placebo;Group 2 ustekinumab 130 mg;Group 3: ustekinumab approximately 6 mg/kg
36 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3 Alendronate
37 Adalimumab on Preventing Post-chirurgic Recurrence on Crohn´s Disease Completed NCT01564823 Phase 3 Metronidazole;Metronidazole;Azathioprine;Adalimumab
38 A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1) Completed NCT01369329 Phase 3 Group 2 ustekinumab 130 mg;Group 3: ustekinumab approximately 6 mg/kg;Group 1: Placebo
39 Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD) Completed NCT01692743 Phase 3
40 Zoledronate for Osteopenia in Pediatric Crohn's Completed NCT00798473 Phase 3 zoledronic acid
41 A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease Completed NCT00078611 Phase 3 natalizumab
42 Efficacy and Safety Study of Mongersen (GED-0301) for the Treatment of Subjects With Active Crohn's Disease Recruiting NCT02596893 Phase 3 GED-0301;Placebo
43 A Long-term Active Treatment Study of Mongersen (GED-0301) in Subjects With Crohn's Disease Recruiting NCT02641392 Phase 3 GED-0301
44 Vedolizumab Subcutaneous Long-Term Open-Label Extension Study Recruiting NCT02620046 Phase 3 Vedolizumab SC
45 BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity Recruiting NCT02871635 Phase 3 BI 695501;HUMIRA
46 A Study of the Safety and Efficacy of Etrolizumab in Patients With Moderately to Severely Active Crohn's Disease Recruiting NCT02394028 Phase 3 Etrolizumab 210 mg;Etrolizumab 105 mg;Placebo
47 Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Crohn's Disease Recruiting NCT02914561 Phase 3 Filgotinib;Placebo to match filgotinib
48 A Study of the Efficacy and Safety of Etrolizumab in Ulcerative Colitis Participants Who Are Refractory to or Intolerant of Tumor Necrosis Factor (TNF) Inhibitors Recruiting NCT02100696 Phase 3 Etrozulimab;Placebo
49 Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies Recruiting NCT02118584 Phase 3 Etrolizumab
50 Filgotinib in Long-Term Extension Study of Adults With Crohn's Disease Recruiting NCT02914600 Phase 3 Filgotinib;Placebo

Search NIH Clinical Center for Crohn's Colitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: crohn disease

Genetic Tests for Crohn's Colitis

Anatomical Context for Crohn's Colitis

MalaCards organs/tissues related to Crohn's Colitis:

39
Colon, Skin, T Cells, Bone, Testes, Endothelial, B Cells

Publications for Crohn's Colitis

Articles related to Crohn's Colitis:

(show top 50) (show all 64)
id Title Authors Year
1
Completion Proctectomy for Crohn's Colitis: Lessons Learned. ( 28158506 )
2017
2
Colectomy in refractory Crohn's colitis improves nutrition and reduces steroid use. ( 28864042 )
2017
3
Early histological findings may predict the clinical phenotype in Crohn's colitis. ( 28815033 )
2017
4
Crohn's Colitis: Development of a multiplex gene expression assay comparing mRNA levels of susceptibility genes. ( 28365139 )
2017
5
Letter: small bowel recurrence and fate of the rectum after total colectomy and ileostomy for Crohn's colitis. ( 28211630 )
2017
6
Clinical recurrence and re-resection rates after extensive vs. segmental colectomy in Crohn's colitis: a retrospective cohort study. ( 26886936 )
2016
7
Listeria Rhombencephalitis Complicating Anti-TNF Treatment during an Acute Flare of Crohn's Colitis. ( 27651962 )
2016
8
Challenges in detection and real-time diagnosis of dysplasia in Crohn's colitis: the search still continues. ( 27102530 )
2016
9
Changes in biosimilar knowledge among European Crohn's Colitis Organization (ECCO) members : A updated survey. ( 27112706 )
2016
10
Indolent T-cell lymphoproliferative disease of the gastro-intestinal tract following treatment with Adalimumab in resistant Crohn's colitis. ( 27402301 )
2016
11
pANCA and ASCA in Children with IBD-Unclassified, Crohn's Colitis, and Ulcerative Colitis-A Longitudinal Report from the IBD Porto Group of ESPGHAN. ( 27135480 )
2016
12
DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance. ( 27104828 )
2016
13
Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer. ( 27026089 )
2016
14
Colorectal polyps in ulcerative colitis and Crohn's colitis. ( 26446684 )
2015
15
P621. Comparison between total abdominal colectomy and segmental colectomy in Crohn's colitis patients: Recurrence and re-resection rates. A retrospective cohort study. ( 25718123 )
2015
16
DOP045. pANCA and ASCA in > 400 children with IBD-unclassified (IBD-U), Crohn's Colitis and Ulcerative Colitis (UC) - a longitudinal report from the Porto pediatric IBD group of ESPGHAN. ( 25718257 )
2015
17
Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn's colitis. ( 26140094 )
2015
18
DOP047. Long Term Outcome of Segmental Resection for Crohn's Colitis: an Observational Study on 200 Patients. ( 25718260 )
2015
19
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
20
Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. ( 26434930 )
2015
21
Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohn's colitis. ( 25725040 )
2015
22
Significance of the epithelioid granuloma in biopsies of Crohn's colitis. ( 25208107 )
2014
23
Detection rate and outcome of colonic serrated epithelial changes in patients with ulcerative colitis or Crohn's colitis. ( 24779703 )
2014
24
FOXP3+ regulatory T-cell counts correlate with histological response in Crohn's colitis treated with infliximab. ( 25354875 )
2014
25
Herpes simplex virus blepharitis in a patient with Crohn's colitis. ( 24613714 )
2014
26
A patient with severe Crohn's colitis responds to Faecal Microbiota Transplantation. ( 24239403 )
2014
27
Subtotal colectomy in severe ulcerative and Crohn's colitis: what benefit does the laparoscopic approach confer? ( 25379999 )
2014
28
Fecal microbiota transplantation inducing remission in Crohn's colitis and the associated changes in fecal microbial profile. ( 24667590 )
2014
29
Colorectal cancer and Crohn's colitis: clinical implications from 313 surgical patients. ( 23381673 )
2013
30
Risk of permanent stoma in extensive Crohn's colitis: the impact of biological drugs. ( 23594132 )
2013
31
Intestinal microbiota transplantation: a case of Crohn's colitis with superimposed Clostridium difficile infection. ( 24831911 )
2013
32
Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients. ( 22532293 )
2013
33
Case series: does a combination of anti-tnf antibodies and transient ileal fecal stream diversion in severe Crohn's colitis with perianal fistula prevent definitive stoma? ( 24091520 )
2013
34
Proteomic patterns of colonic mucosal tissues delineate Crohn's colitis and ulcerative colitis. ( 23382084 )
2013
35
Early histological findings quantified by histomorphometry allow prediction of clinical phenotypes in Crohn's colitis patients. ( 23700718 )
2013
36
High rates of metachronous colon cancer or dysplasia after segmental resection or subtotal colectomy in Crohn's colitis. ( 23669402 )
2013
37
About the colorectal cancer screening and surveillance in Crohn's colitis. ( 23478507 )
2013
38
Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis. ( 23643741 )
2013
39
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis. ( 23681475 )
2013
40
Lymphoid aggregates in Crohn's colitis and mucosal immunity. ( 23979405 )
2013
41
An easy method to quantify plasma cells/plasma cell precursors in normal colonic mucosa, collagenous colitis and Crohn's colitis. ( 22993311 )
2012
42
Recurrent drug-induced ANCA vasculitis in a patient with Crohn's colitis treated with infliximab: a potential contraindication to immunosuppressive therapy. ( 23265134 )
2012
43
Increased risk of colorectal cancer and dysplasia in patients with Crohn's colitis and primary sclerosing cholangitis. ( 21979184 )
2011
44
Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options. ( 20090331 )
2010
45
Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis. ( 18255351 )
2008
46
Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility. ( 17763471 )
2007
47
Early changes in rectal nitric oxide and mucosal inflammatory mediators in Crohn's colitis in response to infliximab treatment. ( 17402996 )
2007
48
[Levels of cytokines in mucosal biopsies of Crohn's colitis. Physiopatological observations]. ( 11832856 )
2002
49
Obliterative arteritis with nitric oxide synthase and HLA-DR expression in Crohn's colitis. ( 11379318 )
2001
50
Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. ( 11559654 )
2001

Variations for Crohn's Colitis

Expression for Crohn's Colitis

Search GEO for disease gene expression data for Crohn's Colitis.

Pathways for Crohn's Colitis

Pathways related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CDH1 CXCL8 IFNG IL1B IL2 NOD2
2
Show member pathways
13.74 CDH1 CDH3 CXCL8 IL1B IL2 NOS2
3
Show member pathways
13.55 CXCL8 IFNG IL1B IL2 NOS2 TNF
4
Show member pathways
13.44 CDH1 CXCL8 IFNG IL1B IL2 TNF
5
Show member pathways
13.27 CXCL8 IFNG IL1B IL2 NOD2 NOS2
6
Show member pathways
13.2 CDH1 CXCL8 IL1B IL2 TNF
7
Show member pathways
12.93 CXCL8 IL1B NOD2 NOS2 TNF
8
Show member pathways
12.81 CXCL8 IFNG IL1B IL2 TNF
9
Show member pathways
12.78 CXCL8 IFNG IL1B IL2 NOS2 TNF
10
Show member pathways
12.75 CXCL8 IFNG IL1B IL2 TNF
11
Show member pathways
12.66 CXCL8 IFNG IL1B TNF
12
Show member pathways
12.56 IFNG IL1B IL2 NOD2 TNF
13
Show member pathways
12.54 IFNG IL1B IL2 NOS2 TNF
14 12.49 IFNG IL1B IL2 TNF
15
Show member pathways
12.4 IFNG IL1B IL2 TNF
16
Show member pathways
12.31 CXCL8 IFNG IL1B TNF
17
Show member pathways
12.23 IFNG IL1B NOS2 TNF
18
Show member pathways
12.19 CXCL8 IFNG IL1B NOS2 TNF
19 12.17 CDH1 IFNG NOS2 TNF
20 12.16 IFNG IL1B NOD2 NOS2 TNF
21 12.11 CXCL8 IL1B TNF
22
Show member pathways
12.09 CXCL8 IFNG IL1B NOS2 TNF
23 12.04 IFNG IL1B TNF
24 11.99 IFNG IL1B TNF
25
Show member pathways
11.98 CXCL8 IFNG IL1B IL2 TNF
26 11.96 CXCL8 IL1B NOS2 TNF
27 11.95 IFNG IL2 TNF
28
Show member pathways
11.95 IFNG IL1B IL2 NOS2
29 11.92 IL1B NOD2 TNF
30
Show member pathways
11.92 IFNG IL1B IL2 TNF
31 11.91 CXCL8 IFNG IL1B
32 11.87 CXCL8 IL1B TNF
33 11.85 CXCL8 IL1B TNF
34 11.83 CXCL8 IFNG IL1B TNF
35 11.8 CXCL8 IFNG IL1B NOS2
36 11.79 CXCL8 IFNG IL2
37 11.76 IFNG IL1B IL2 TNF
38
Show member pathways
11.73 CXCL8 IFNG IL2 TNF
39 11.72 CXCL8 IL1B NOS2 TNF
40 11.66 CXCL8 IL1B TNF
41
Show member pathways
11.65 IFNG IL2 TNF
42 11.64 CXCL8 IFNG IL1B NOS2 TNF
43 11.6 CXCL8 IFNG NOS2
44 11.6 CXCL8 IL1B TNF
45 11.56 IFNG IL2 TNF
46 11.53 CXCL8 IL1B TNF
47 11.49 IFNG IL1B TNF
48 11.45 CXCL8 IFNG IL1B TNF
49 11.43 CDH1 IFNG IL1B IL2 TNF
50
Show member pathways
11.42 IFNG IL2 TNF

GO Terms for Crohn's Colitis

Cellular components related to Crohn's Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CXCL8 IFNG IL1B IL2 SLIT2 TNF
2 extracellular region GO:0005576 9.17 CDH1 CXCL8 IFNG IL1B IL2 SLIT2

Biological processes related to Crohn's Colitis according to GeneCards Suite gene sharing:

(show all 45)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 CDH3 IFNG IL1B TNF
2 immune response GO:0006955 9.89 CXCL8 IFNG IL1B IL2 TNF
3 negative regulation of gene expression GO:0010629 9.87 IFNG NOS2 TNF
4 positive regulation of cell proliferation GO:0008284 9.86 IFNG IL2 NOD2
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B NOD2 TNF
6 defense response to bacterium GO:0042742 9.85 IFNG NOD2 NOS2 TNF
7 defense response GO:0006952 9.84 CXCL8 NOD2 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B NOD2 TNF
9 activation of MAPK activity GO:0000187 9.8 IL1B NOD2 TNF
10 cellular response to organic cyclic compound GO:0071407 9.77 IL1B NOD2 TNF
11 positive regulation of JNK cascade GO:0046330 9.76 IL1B NOD2 TNF
12 neutrophil chemotaxis GO:0030593 9.75 CXCL8 IFNG IL1B
13 positive regulation of T cell proliferation GO:0042102 9.74 IFNG IL1B IL2
14 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL1B IL2 TNF
15 positive regulation of phagocytosis GO:0050766 9.69 IL1B TNF
16 protein import into nucleus, translocation GO:0000060 9.69 IFNG TNF
17 positive regulation of interleukin-1 beta secretion GO:0050718 9.69 IFNG NOD2
18 positive regulation of interleukin-6 production GO:0032755 9.69 IL1B NOD2 TNF
19 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.67 NOD2 TNF
21 positive regulation of NF-kappaB import into nucleus GO:0042346 9.67 IL1B TNF
22 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
23 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL8 IFNG NOS2 TNF
24 embryonic digestive tract development GO:0048566 9.66 CXCL8 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.65 IFNG TNF
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
29 positive regulation of interleukin-17 production GO:0032740 9.64 IL2 NOD2
30 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B IL2 TNF
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
32 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IFNG IL2
33 regulation of defense response to virus by host GO:0050691 9.61 IFNG IL1B
34 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 IFNG IL1B
35 regulation of establishment of endothelial barrier GO:1903140 9.6 IL1B TNF
36 positive regulation of fever generation GO:0031622 9.56 IL1B TNF
37 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
38 positive regulation of killing of cells of other organism GO:0051712 9.52 IFNG NOS2
39 positive regulation of interleukin-8 production GO:0032757 9.5 IL1B NOD2 TNF
40 regulation of insulin secretion GO:0050796 9.46 IFNG IL1B NOS2 TNF
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IFNG IL1B TNF
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
43 positive regulation of chemokine biosynthetic process GO:0045080 9.13 IFNG IL1B TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF
45 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.08 IFNG IL1B IL2 NOD2 TNF

Molecular functions related to Crohn's Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IFNG IL1B IL2 TNF

Sources for Crohn's Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
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52 Novoseek
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59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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