MCID: CRH001
MIFTS: 75

Crohn's Disease malady

Genetic diseases, Rare diseases, Gastrointestinal diseases categories

Summaries for Crohn's Disease

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MedlinePlus:33 Crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Crohn's Disease, also known as crohn disease, is related to ulcerative colitis and arthritis. An important gene associated with Crohn's Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways is Leishmaniasis. The drugs azathioprine and thalidomide and the compounds peptidoglycan and il 10 have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and small intestine.

Disease Ontology:9 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference:22 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

NIH Rare Diseases:42 Crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the intestines. common signs and symptoms include abdominal pain and diarrhea. bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. other problems can include intestinal blockage and malnutrition. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery.┬áquitting smoking can also improve the symptoms of crohnÔÇÖs disease. last updated: 11/15/2012

Wikipedia:64 Crohn\'s disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel... more...

Aliases & Classifications for Crohn's Disease

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Crohn's Disease, Aliases & Descriptions:

Name: Crohn's Disease 31 9 64 42 22 33
Crohn Disease 9 21 22 61
Pediatric Crohn's Disease 9 42 61
Ileitis 42 22 61
Regional Enteritis of the Large Bowel 9 61
Pediatric Onset Crohn's Disease 42 61
Crohn's Disease of Large Bowel 9 61
Crohn's Disease of Colon 9 61
Granulomatous Enteritis 42 61
Granulomatous Colitis 9 42
Regional Ileocolitis 9 61
Crohn's Enteritis 22 61
 
Ileocolitis 22 61
Enteritis 42 61
Regional Enteritis of Small Intestine with Large Intestine 9
Crohn's Disease of the Ileum 61
Crohn's Disease, Pediatric 42
Enteritis, Granulomatous 22
Colitis, Granulomatous 22
Enteritis, Regional 22
Regional Colitis 9
Regional Ileitis 9
Crohns Disease 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:8778
NCIt39 C35210
ICD9CM28 555.0
ICD1026 K50, K50.9

Related Diseases for Crohn's Disease

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Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to crohn's disease

Symptoms for Crohn's Disease

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Drugs & Therapeutics for Crohn's Disease

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Genetic Tests for Crohn's Disease

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Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease21 NOD2

Anatomical Context for Crohn's Disease

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MalaCards organs/tissues related to Crohn's Disease:

32
Colon, Small intestine, Skin, Testes, Bone, T cells, Eye, Kidney, Monocytes, Endothelial, Liver, Neutrophil, Bone marrow, Smooth muscle, B cells, Lymph node, Thyroid, Whole blood, Myeloid, Appendix, Thymus, Skeletal muscle, Lung, Pancreas, Tonsil

FMA organs/tissues related to Crohn's Disease:

15
Intestine

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Crohn's Disease or affiliated genes

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Publications for Crohn's Disease

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Articles related to Crohn's Disease:

(show top 50)    (show all 2334)
idTitleAuthorsYear
1
Quality of care in Crohn's disease. (25400990)
2014
2
Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy. (24148619)
2014
3
Takayasu's Arteritis and Crohn's Disease in a Young Hispanic Female. (25152825)
2014
4
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. (23266558)
2013
5
The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis. (24252895)
2013
6
Mucosal barrier in ulcerative colitis and Crohn's disease. (23737764)
2013
7
Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn's disease: A meta-analysis. (24307809)
2013
8
Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease. (23749272)
2013
9
Incidence, clinical characteristics, long-term course, and comparison of progressive and nonprogressive cases of aphthous-type Crohn's disease: a single-center cohort study. (23751515)
2013
10
American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-I+ biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease. (24267475)
2013
11
Is really megacolon a contraindication to infliximab in Crohn's disease? (24592552)
2013
12
Auricular pyoderma gangrenosum associated with Crohn's disease. (22585655)
2012
13
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
14
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
15
Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients. (21688348)
2012
16
The cystic fibrosis F508del mutation in Crohn's disease. (21131241)
2011
17
Concurrent small bowel adenocarcinoma and carcinoid tumor in Crohn's disease--case report and literature review. (21939921)
2011
18
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (20846217)
2010
19
Portal cavernoma in a patient with Crohn's disease associated with factor V Leiden mutation and antiphospholipid syndrome. (21188340)
2010
20
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. (18936107)
2009
21
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. (19587699)
2009
22
Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population. (19276991)
2009
23
Mushroom intolerance: a novel diet-gene interaction in Crohn's disease. (19660151)
2009
24
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
25
Increased subpopulations of CD16(+) and CD56(+) blood monocytes in patients with active Crohn's disease. (17260384)
2007
26
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. (17877509)
2007
27
Analysis of soluble angiogenic factors in Crohn's disease: a preliminary study. (17980128)
2007
28
Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants. (17876878)
2007
29
Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. (17206716)
2007
30
CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease. (17504508)
2007
31
Clinically active Crohn's disease in the presence of a low C-reactive protein. (16497618)
2006
32
The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease. (16984505)
2006
33
TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease. (15937090)
2005
34
CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease. (15551253)
2004
35
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. (14561165)
2003
36
Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): results of a randomized, open-label, pilot study. (12534402)
2003
37
Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case. (12032437)
2002
38
Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients. (12353858)
2002
39
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. (11788561)
2002
40
Therapeutic inhibitors of tumor necrosis factor in Crohn's disease. (12498004)
2002
41
Thalidomide treatment for refractory Crohn's disease: a review of the history, pharmacological mechanisms and clinical literature. (11730158)
2001
42
Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission. (11008719)
2000
43
Beta2 integrin/ICAM expression in Crohn's disease. (9473377)
1998
44
Mapping of a susceptibility locus for Crohn's disease on chromosome 16. (8587604)
1996
45
Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. (7523224)
1994
46
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
47
Antibodies to cathepsin G in Crohn's disease. (1633838)
1992
48
T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. (2298368)
1990
49
Small bowel adenocarcinoma and Crohn's disease. (3818257)
1986
50
Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. (6132589)
1983

Variations for Crohn's Disease

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Expression for genes affiliated with Crohn's Disease

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Expression patterns in normal tissues for genes affiliated with Crohn's Disease

Search GEO for disease gene expression data for Crohn's Disease.

Pathways for genes affiliated with Crohn's Disease

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Pathways related to Crohn's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0NOD2, IL6, IRGM

Compounds for genes affiliated with Crohn's Disease

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Sources:
44Novoseek, 29IUPHAR, 50PharmGKB, 12DrugBank
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Compounds related to Crohn's Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1peptidoglycan44 2911.2NOD2, IL6
2il 104410.1NOD2, IL6
3infliximab44 50 1211.9NOD2, IL6

GO Terms for genes affiliated with Crohn's Disease

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Cellular components related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:03067010.2SLC11A1, IRGM

Biological processes related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:05087110.4NOD2, IL6
2positive regulation of dendritic cell antigen processing and presentationGO:00260610.4SLC11A1, NOD2
3defense response to protozoanGO:04283210.4SLC11A1, IL6
4positive regulation of phagocytosisGO:05076610.3SLC11A1, NOD2
5defense response to Gram-negative bacteriumGO:05082910.3IL6, SLC11A1
6defense response to Gram-positive bacteriumGO:05083010.3NOD2, IL6
7response to lipopolysaccharideGO:03249610.3IL6, NOD2, SLC11A1
8positive regulation of interleukin-6 productionGO:03275510.2NOD2, IL6
9positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2NOD2, IL6
10positive regulation of epithelial cell proliferationGO:05067910.1IL6, NOD2
11inflammatory responseGO:0069549.7SLC11A1, IL6, IRGM

Products for genes affiliated with Crohn's Disease

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Sources for Crohn's Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet