MCID: CRH001
MIFTS: 83

Crohn's Disease malady

Gastrointestinal diseases category

Summaries for Crohn's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Crohn's Disease, also known as crohn disease, is related to ulcerative colitis and hepatitis. An important gene associated with Crohn's Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Immune System and Leishmaniasis. The drugs azathioprine and cholecalciferol and the compounds epinephrine and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and small intestine, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference:21 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

NIH Rare Diseases:42 Crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the intestines. common signs and symptoms include abdominal pain and diarrhea. bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. other problems can include intestinal blockage and malnutrition. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. quitting smoking can also improve the symptoms of crohn’s disease. last updated: 11/15/2012

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Wikipedia:63 Crohn\'s disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel... more...

Aliases & Classifications for Crohn's Disease

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Sources:
8Disease Ontology, 63Wikipedia, 42NIH Rare Diseases, 21Genetics Home Reference, 33MedlinePlus, 30LifeMap Discovery™, 20GeneTests, 60UMLS, 44Novoseek, 10DISEASES, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

crohn's disease 8 63 42 21 33 30
crohn disease 8 20 21 60
ileitis 42 21 44 60
crohn's disease of large bowel 8 60
pediatric crohn's disease 8 60
granulomatous colitis 8 42
regional ileocolitis 8 60
enteritis 42 60
regional enteritis of small intestine with large intestine 8
regional enteritis of the large bowel 8
pediatric onset crohns disease 42
crohn's disease of the ileum 60
crohns disease, pediatric 42
pediatric crohns disease 42
enteritis, granulomatous 21
crohn's disease of colon 8
granulomatous enteritis 42
colitis, granulomatous 21
enteritis, regional 21
crohn's enteritis 21
regional colitis 8
regional ileitis 8
crohn's colitis 8
crohns disease 10
eleocolitis 8
ileocolitis 21
iieocolitis 60


External Ids:

Disease Ontology8 DOID:8778
NCIt39 C35210
ICD9CM27 555.0
ICD1025 K50, K50.9

Related Diseases for Crohn's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 535)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.6IBD5, TNFSF15, DEFA5, IL6, IL23R, SLC11A1
2hepatitis30.5HP
3adenocarcinoma30.3CD44
4psoriasis30.2IL6, IL23R, SLC22A5, NOD2
5tuberculosis30.2IRGM, HP, SLC11A1, NOD2
6arthritis30.0SAA1, CD44, HP, IL6, SLC11A1, NOD2
7deficiency anemia30.0SLC11A1, IL6, HP, SAA1
8hepatitis c29.9HP
9rheumatoid arthritis29.8SAA1, CD44, HP, IL18BP, IL6, IL23R
10inflammatory bowel disease29.8NOD2, TNFSF15, DEFA5, IL6, IL23R, SLC22A4
11colorectal cancer29.8NOD2, CD44
12dermatitis29.8NOD2
13hemochromatosis29.8HP
14sarcoidosis29.6NOD2, SLC11A1, IL12RB2
15asthma29.6IL12RB2, SLC11A1, NOD2
16periodontal disease29.6IL6
17neuronitis10.6
18short bowel syndrome10.5
19intestinal disease10.4
20hirschsprung's disease10.4
21intestinal obstruction10.3
22typhoid fever10.3
23burns10.3
24gastroenteritis10.3
25intestinal pseudo-obstruction10.3
26acute diarrhea10.3
27reactive arthritis10.3
28coccidiosis10.3
29colonic disease10.3
30hermansky-pudlak syndrome10.3
31duodenitis10.2
32syndromic diarrhea10.2
33peritonitis10.2
34chromosomal disease10.2
35campylobacteriosis10.1
36steatorrhea10.1
37paratyphoid fever10.1
38esophageal cancer10.1
39lipoma10.1
40exocrine pancreatic insufficiency10.1
41hepatitis a10.1
42meningitis10.1
43intestinal tuberculosis10.1
44leukemia10.1
45retinal disease10.1
46retinitis10.1
47vasculitis10.1
48anisakiasis10.1
49intestinal schistosomiasis10.1
50mesenteric lymphadenitis10.1

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to crohn's disease

Clinical Features for Crohn's Disease

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Drugs & Therapeutics for Crohn's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Genetic Tests for Crohn's Disease

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20GeneTests
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Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease20 NOD2

Anatomical Context for Crohn's Disease

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30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Crohn's Disease:

32
Colon, Small intestine, Skin, Testes, Bone, T cells, Eye, Kidney, Monocytes, Endothelial, Liver, Bone marrow, Smooth muscle, B cells, Thyroid, Lymph node, Appendix, Whole blood, Myeloid, Thymus, Lung, Pancreas, Tonsil, Skeletal muscle

FMA organs/tissues related to Crohn's Disease:

14
Intestine

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Crohn's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Crohn's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538712.4NOD2, TNFSF15, IRGM, ATG16L1, NKX2-3, CD44
2MP:000539712.0TNFSF15, NKX2-3, CD44, HP, IL12RB2, IL6
3MP:000538411.9ATG16L1, NKX2-3, CD44, HP, IL12RB2, IL6
4MP:000537611.8SAA1, IRGM, NKX2-3, CD44, HP, IL12RB2
5MP:000538111.6ATG16L1, NKX2-3, CD44, IL12RB2, IL6, SLC11A1
6MP:000200610.9HP, IL6, SLC11A1

Publications for Crohn's Disease

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Sources:
50PubMed
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Articles related to Crohn's Disease:

(show top 50)    (show all 2261)
idTitleAuthorsYear
1
Pyogenic liver abscesses: a serious but often unrecognized hepatic complication of Crohn's disease. (24247652)
2014
2
Capsule endoscopy in the diagnosis of Crohn's disease. (23818810)
2013
3
Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis. (23946888)
2013
4
Bacterial translocation influences the response to biological therapy in Crohn's disease. (23973858)
2013
5
Enteroscopy in small bowel Crohn's disease: A review. (24147191)
2013
6
Phenotypic Features of Crohn's Disease Associated With Failure of Medical Treatment. (23978351)
2013
7
Mortality and causes of death in Crohn's disease: results from 20 years of follow-up in the IBSEN study. (23744613)
2013
8
Surgery for Crohn's disease and anti-TNF agents: the changing scenario. (24161133)
2013
9
Smoking does influence disease behaviour and impacts the need for therapy in Crohn's disease in the biologic era. (23980933)
2013
10
Mechanism and therapeutic strategy of secondary failure to anti-tumor necrosis factor-I+ monoclonal antibody treatment for Crohn's disease. (23797247)
2013
11
Massive pyoderma gangrenosum in a 77 year old female with Crohn's disease responsive to adalimumab. (22926276)
2013
12
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
13
Can an immunohistochemistry method differentiate intestinal tuberculosis from Crohn's disease in biopsy specimens? (20824497)
2011
14
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (19760754)
2010
15
Crohn's colitis with perianal disease complicated by collagenous colitis: discourse on management options. (20090331)
2010
16
Expression and regulation of the chemokine CXCL16 in Crohn's disease and models of intestinal inflammation. (20848509)
2010
17
Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. (21072187)
2010
18
Mushroom intolerance: a novel diet-gene interaction in Crohn's disease. (19660151)
2009
19
Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants. (19492906)
2009
20
CD68 expression is markedly different in Crohn's disease and the colitis associated with chronic granulomatous disease. (19229980)
2009
21
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. (19221600)
2009
22
Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa. (18839424)
2009
23
Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease. (19398441)
2009
24
Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab. (18240280)
2008
25
Fecal calprotectin, lactoferrin, and endoscopic disease activity in monitoring anti-TNF-alpha therapy for Crohn's disease. (18484671)
2008
26
Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease. (17206681)
2007
27
1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. (17996686)
2007
28
Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation. (16461743)
2006
29
TNFalpha genotype influences development of IgA-ASCA antibodies in Crohn's disease patients with CARD15 wild type. (16952484)
2006
30
Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease. (16450309)
2006
31
Infliximab for treatment of resistant pyoderma gangrenosum associated with Crohn's disease. (17982610)
2006
32
Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease. (16307694)
2005
33
Failure to replicate the association of the novel NOD2/CARD15 haplotype (S268P-JW1) to Crohn's disease in the Jewish Israeli population. (14765395)
2004
34
Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease. (15479684)
2004
35
Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease. (15472511)
2004
36
Circulating monocytes and plasma inflammatory biomarkers in active Crohn's disease: elevated oxidized low-density lipoprotein and the anti-inflammatory effect of atorvastatin. (15290911)
2004
37
Medical therapy for Crohn's disease strictures. (15058528)
2004
38
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. (12512038)
2003
39
Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients. (14752224)
2003
40
Review article: maintenance treatment of Crohn's disease. (12786610)
2003
41
Review article: the immunoregulatory cytokine interleukin-10--a therapy for Crohn's disease? (11683684)
2001
42
Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease. (11709514)
2001
43
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation. (10657017)
2000
44
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. (10352304)
1999
45
Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16. (9924607)
1998
46
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). (7797011)
1995
47
Leukotriene B4 receptor levels and intracellular calcium signalling in polymorphonuclear leukocytes from patients with Crohn's disease. (7600141)
1995
48
Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis. (7828979)
1994
49
Diminished cytochrome b content and toxic oxygen metabolite production in circulating neutrophils from patients with Crohn's disease. (8395381)
1993
50
Small bowel adenocarcinoma and Crohn's disease. (3818257)
1986

Genetic Variations for Crohn's Disease

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Expression for genes affiliated with Crohn's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crohn's Disease

Search GEO for disease gene expression data for Crohn's Disease.

Pathways for genes affiliated with Crohn's Disease

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Crohn's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5IL6, CD44, DEFA5, DEFA6, SAA1, UBE4A
2
Hide members
11.3NOD2, IL23R, IL6, IL12RB2, IRGM
311.1TNFSF15, ATG16L1, CD44, IL6
4
Hide members
10.8SLC22A5, SLC22A4
510.8DEFA6, DEFA5

Compounds for genes affiliated with Crohn's Disease

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1epinephrine44 11 2413.4SLC22A5, IL6, HP, CD44
2vitamin d4411.3SLC11A1, IL6, HP, CD44
3hbd24411.3IL6, DEFA5, DEFA6
4endotoxin4411.1IL18BP, SAA1
5cirazoline4411.1SLC22A4, SLC22A5
6moxa4411.1SLC22A4, SLC22A5
7tiotropium49 44 28 1114.1SLC22A5, SLC22A4
8ipratropium bromide44 1112.1SLC22A4, SLC22A5
9Penicillin G1111.0SLC22A4, SLC22A5
10tenidap44 2812.0SAA1, IL6
11moxonidine4411.0SLC22A4, SLC22A5
12Aminohippurate1111.0SLC22A4, SLC22A5
13ulinastatin4410.9HP, IL6
14procainamide44 1111.9SLC22A4, SLC22A5
15mepyramine44 1111.8SLC22A4, SLC22A5
16ofloxacin44 2 1112.8SLC22A5, SLC22A4
17L-Carnitine11 2411.7SLC22A5, SLC22A4
18prednisolone44 28 1112.7NOD2, IL6, CD44

GO Terms for genes affiliated with Crohn's Disease

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16Gene Ontology
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Cellular components related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4IL6, TNFSF15, DEFA6, DEFA5, HP, IL18BP
2autophagic vacuole membraneGO:00042110.8ATG16L1, IRGM
3endocytic vesicle lumenGO:07168210.5HP, SAA1

Biological processes related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:03249611.8NOD2, SLC11A1, IL23R, IL6, IL18BP, IL12RB2
2defense response to bacteriumGO:04274211.6DEFA6, DEFA5, HP, SLC11A1, NOD2
3innate immune responseGO:04508711.3SAA1, IRGM, DEFA6, DEFA5, NOD2
4defense response to Gram-negative bacteriumGO:05082911.3IL6, IL23R, SLC11A1
5positive regulation of interferon-gamma productionGO:03272911.3SLC11A1, IL23R, IL12RB2
6acute-phase responseGO:00695311.2SAA1, HP, IL6
7inflammatory responseGO:00695411.2IRGM, IL6, IL23R, SLC11A1
8positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.2NOD2, IL6, CD44
9quaternary ammonium group transportGO:01569711.1SLC22A5, SLC22A4
10positive regulation of ERK1 and ERK2 cascadeGO:07037411.1NOD2, IL6, CD44
11carnitine transportGO:01587911.1SLC22A5, SLC22A4
12positive regulation of B cell activationGO:05087111.1NOD2, IL6
13positive regulation of dendritic cell antigen processing and presentationGO:00260611.0SLC11A1, NOD2
14positive regulation of T-helper 1 type immune responseGO:00282711.0SLC11A1, IL23R
15positive regulation of interleukin-17 productionGO:03274011.0IL23R, NOD2
16killing of cells of other organismGO:03164010.9DEFA5, DEFA6
17response to interferon-gammaGO:03434110.8SLC11A1, IL23R
18defense response to protozoanGO:04283210.7SLC11A1, IL6
19defense response to fungusGO:05083210.5DEFA5, DEFA6

Molecular functions related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1quaternary ammonium group transmembrane transporter activityGO:01565110.8SLC22A5, SLC22A4
2carnitine transmembrane transporter activityGO:01522610.5SLC22A5, SLC22A4

Products for genes affiliated with Crohn's Disease

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Sources for Crohn's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet