Crohn's Disease malady

MedlinePlus: Crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. the disease can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. crohn's disease seems to run in some families. it can occur in people of all age groups but is most often diagnosed in young adults. common symptoms are pain in the abdomen and diarrhea. bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. children with the disease may have growth problems. other problems can include intestinal blockage and malnutrition. treatment may include medicines, nutrition supplements, surgery or a combination of these options. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Crohn's Disease, also known as ileitis, is related to carcinoma and leukemia. An important gene associated with Crohn's Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Antioxidant Action of Vitamin-C and p38 Signaling. The drugs ceftriaxone sodium and ceftriaxone and the compounds lipid and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include intestine, bone marrow and whole blood, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: An intestinal disease that involves inflammation located in intestine.⁶

CDC: Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.²

Genetics Home Reference: Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).¹⁷

Wikipedia: Crohn\'s disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel...⁴⁴ more...

Aliases & Descriptions:

crohn's disease 6 44 16 17 23 ileitis 17 32 43 crohn's disease of large bowel 6 43 regional ileocolitis 6 43 crohn disease 17 43 regional enteritis of small intestine with large intestine 6 regional enteritis of the large bowel 6 crohn's disease of colon (disorder) 6 crohn's disease of the ileum 43 enteritis, granulomatous 17 colitis, granulomatous 17 granulomatous colitis 6

enteritis, regional 17 regional colitis 6 regional ileitis 6 crohn's colitis 6 crohns disease 8 eleocolitis 6 ileocolitis 17 iieocolitis 43 enteritis 43 colitis 43

Diseases related to crohn's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1042)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	68.1	PIGR, PIK3C2A, PI3, KLF4, REG3A, REG4
2	leukemia	57.5	PIK3C2A, KLF4, NCF4, NCR1, NCR2, REL
3	ulcerative colitis	55.7	PI3, REG4, SFRP2, GCG, SELE, SELL
4	pancreatitis	53.9	PIK3C2A, PI3, KLF4, REG3A, REG4, RETN
5	inflammatory bowel disease	53.5	PIGR, REG3A, REG4, RETN, GCG, SELE
6	prostatitis	51.8	PIK3C2A, KLF4, REG4, REL, RETN, CNR1
7	neuronitis	49.7	PIK3C2A, SH2B1, KLF4, NDFIP1, NCF4, REG3A
8	lupus erythematosus	48.5	PIK3C2A, REL, RETN, KIR2DL1, KIR2DL3, KIR2DL2
9	psoriasis	47.5	PI3, RETN, CNR1, KIR2DL1, KIR2DL3, KIR2DL2
10	fibrosis	47.5	PI3, REG3A, RETN, CNR1, VTN, SELE
11	adenocarcinoma	46.9	PIGR, PIK3C2A, KLF4, NCR2, REG3A, REG4
12	melanoma	45.9	PIK3C2A, PI3, REL, KIR2DL1, KIR2DL3, KIR2DL2
13	spondylitis	45.0	ZNF365, KIR2DL1, KIR2DL3, KIR2DL2, GCKR, BTNL2
14	gastric cancer	44.3	ZNF300, KLF4, REG3A, REG4, RETN, VTN
15	pediatric crohns disease	44.3	ZNF678, BSN, LIN28B, PAX5, ZBTB38, LBP
16	thyroiditis	43.4	PIK3C2A, KLF4, RETN, VTN, GCG, SELE
17	pulmonary disease	41.6	PI3, RETN, SELE, SELL, SERPINC1, SERPINA1
18	ovarian cancer	41.3	REL, VTN, SELE, SERPINC1, SERPINA1, SERPINE1
19	colon cancer	41.2	KLF4, REG4, RETN, CNR1, GCG, SELE
20	systemic lupus erythematosus	41.1	VTN, SELE, VIP, NAT2, BLZF1, CIITA
21	sarcoidosis	40.9	PIK3C2A, KIR2DL3, VTN, BTNL2, SELE, SELL
22	pneumonia	40.7	PIGR, PIK3C2A, PI3, VTN, SELE, SELL
23	cervicitis	40.4	NCR1, NCR2, CNR1, KIR2DL1, KIR2DL3, KIR2DL2
24	colon carcinoma	40.3	PIGR, KLF4, CNR1, VTN, SELE, SELL
25	dermatitis	39.7	PIK3C2A, PI3, NCR1, NCR2, REL, CNR1
26	adenoma	39.4	KLF4, REG3A, REG4, RETN, CNR1, SFRP2
27	cholesterol	39.1	PIK3C2A, REL, RETN, CNR1, VTN, GCKR
28	esophagitis	39.0	PIK3C2A, KLF4, CNR1, SFRP2, GCG, BTNL2
29	cystic fibrosis	38.8	PI3, REG3A, SELL, SERPINC1, SERPINA1, VIP
30	cholangitis	38.6	REL, BPI, MUC2, LBR, CFTR, MST1
31	cerebritis	38.4	PIK3C2A, KLF4, NDFIP1, CNR1, VTN, SELE
32	anemia	38.4	NDFIP1, SELE, SELL, SERPINC1, VEGFA, LPL
33	peritonitis	38.0	PIK3C2A, NCR1, NCR2, REG4, KIR2DL1, KIR2DL3
34	alzheimer's disease	37.9	ZNF365, NCR2, CNR1, GCG, SELL, SERPINC1
35	sclerosing cholangitis	37.6	REL, BPI, LBR, CFTR, ATG16L1, MPO
36	influenza	37.4	PIGR, PIK3C2A, NCR1, NCR2, KIR2DL1, KIR2DL2
37	nephropathy	37.4	ZNF365, PIGR, RETN, VTN, GCG, SELE
38	blindness	37.2	PIK3C2A, CNR1, GCG, SELE, SERPINC1, SERPINE1
39	nephritis	37.2	VTN, SELE, SERPINA1, SERPINE1, VEGFA, BMP6
40	arthritis	37.0	SELL, SERPINA1, VIP, MMP3, IL17A, IL1A
41	leprosy	36.8	KIR2DL1, KIR2DL3, KIR2DL2, BTNL2, VIL1, VDR
42	obesity	36.8	PIK3C2A, SH2B1, REG3A, RETN, CNR1, KIR2DL1
43	spondyloarthropathy	36.8	KIR2DL1, KIR2DL3, KIR2DL2, SELE, BMP6, B2M
44	herpes simplex	36.7	NCR1, NCR2, SERPINC1, SERPINE1, VIM, VEGFA
45	uveitis	36.7	KIR2DL1, KIR2DL3, KIR2DL2, SELE, SELL, SERPINA1
46	osteoarthritis	36.7	RETN, CNR1, VTN, BTNL2, SERPINA1, SERPINE1
47	immunodeficiency	36.6	SELL, VIP, BPI, BMP6, BLZF1, CIITA
48	familial mediterranean fever	36.6	KIR2DL1, KIR2DL3, KIR2DL2, SELL, SERPINC1, SERPINE1
49	multiple sclerosis	36.5	BSN, ZMIZ1, CLEC16A, MST1, MST1R, CD24
50	sepsis	36.4	PI3, RETN, VTN, SELE, SELL, SERPINC1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aminosalicylic acid, azathioprine, ceftriaxone, ceftriaxone sodium, cholecalciferol, opium, opium alkaloids hydrochloride, opium,powdered, paregoric [va product], thalidomide

Cell-based therapeutics:

Genetic tests related to crohn's disease:

id	Genetic test	Affiliating Genes
1	Crohn's Disease clinical/research	NOD2

MalaCards organs/tissues related to crohn's disease:

²²

FMA organs/tissues related to crohn's disease:

¹¹

MGI Mouse Phenotypes related to crohn's disease:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	26.0	KLF4, NDFIP1, REL, CNR1, SFRP2, SELE
2	homeostasis/metabolism phenotype	MP:0005376	25.9	PIGR, PIK3C2A, SH2B1, KLF4, NDFIP1, REG3A
3	mortality/aging	MP:0010768	24.3	PIK3C2A, SH2B1, KLF4, NDFIP1, NCF4, NCR1
4	immune system phenotype	MP:0005387	24.2	PIGR, SH2B1, NDFIP1, NCF4, REL, SELL
5	hematopoietic system phenotype	MP:0005397	23.6	PIGR, NDFIP1, NCR1, VAMP3, MYO9B, ZMIZ1
6	growth/size phenotype	MP:0005378	20.7	PIK3C2A, SH2B1, NDFIP1, REL, CNR1, SFRP2
7	cardiovascular system phenotype	MP:0005385	17.8	REL, SFRP2, SELE, SELL, SERPINC1, SERPINE1
8	normal phenotype	MP:0002873	17.7	KLF4, NCR1, VTN, SFRP2, SELE, VIL1
9	digestive/alimentary phenotype	MP:0005381	16.7	PIGR, KLF4, REL, GCG, VEGFA, VDR
10	reproductive system phenotype	MP:0005389	16.1	PIGR, SH2B1, KLF4, SFRP2, VIP, VEGFA
11	behavior/neurological phenotype	MP:0005386	16.1	KLF4, CNR1, SELE, VIM, VIP, BSN
12	nervous system phenotype	MP:0003631	15.2	NDFIP1, REL, CNR1, SFRP2, SERPINC1, VAMP3
13	integument phenotype	MP:0010771	15.0	KLF4, NDFIP1, REL, CNR1, RARG, ZMIZ1
14	respiratory system phenotype	MP:0005388	14.9	NDFIP1, REL, SELL, LPL, SCNN1A, CFTR
15	endocrine/exocrine gland phenotype	MP:0005379	14.7	SH2B1, KLF4, NDFIP1, SFRP2, SELL, RARG
16	liver/biliary system phenotype	MP:0005370	14.3	NDFIP1, REL, RETN, SERPINC1, VEGFA, LPL
17	skeleton phenotype	MP:0005390	14.1	REL, CNR1, VEGFA, VDR, BMP6, RARG
18	embryogenesis phenotype	MP:0005380	14.1	REL, SFRP2, SERPINC1, VIM, RARG, RASIP1
19	tumorigenesis	MP:0002006	13.7	KLF4, SELL, SERPINE1, ZFP36L1, BCL2L1, LEP
20	no phenotypic analysis	MP:0003012	13.7	CNR1, SFRP2, VEGFA, RASIP1, CLN3, PARD3
21	vision/eye phenotype	MP:0005391	13.4	SELE, SERPINC1, VIM, VEGFA, RARG, CLDN11
22	craniofacial phenotype	MP:0005382	13.1	KLF4, RARG, ZMIZ1, LBR, T, CFTR
23	limbs/digits/tail phenotype	MP:0005371	12.8	NDFIP1, SFRP2, VEGFA, VDR, PARD3, LEP
24	muscle phenotype	MP:0005369	12.7	SFRP2, VIM, BSN, VEGFA, LPL, MYLK3
25	adipose tissue phenotype	MP:0005375	11.7	PIK3C2A, RETN, CNR1, SERPINE1, LPL, LEP
26	renal/urinary system phenotype	MP:0005367	11.1	TNFRSF1B, NLRP3, SLC22A5

Articles related to crohn's disease:

(show top 50)    (show all 1089)

id	Title	Authors	Year	Affiliating Genes
1	Association of cytotoxic T lymphocyte associated anti gen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of se rum sCTLA-4 in Crohn's disease. (21251066)	Chen Z.... Xia B.	2011	CTLA4
2	Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (20846217)	Lee J.J.... Hirschhorn J.	2010	CDK6, EFEMP1, IHH
3	Analysis of SNPs with an effect on gene expression id entifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (20601676)	Fransen K.... Weersma R.K.	2010	UBE2L3, ENTPD5, BCL3
4	Crohn's disease susceptibility gene interactions, a N OD to the newcomer ATG16L1. (20875485)	Cadwell K.	2010	NOD2, ATG16L1
5	Genetic Variants in IL-23R and ATG16L1 Independently Predispose to Increased Susceptibility to Crohn's Disease in a Canadian Population. (19276991)	Newman W.G.... Siminovitch K.A.	2009	IL23R, ATG16L1
6	The anti-inflammatory target A(3) adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn's disease. (19426966)	Ochaion A.... Fishman P.	2009	CREB1, ADORA3
7	Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease. (19549264)	KA1bler I.... Wehkamp J.	2009	DEFA5, DEFA6
8	Infliximab dependency in children with Crohn's disease. (19183163)	Duricova D.... Munkholm P.	2009	TNF, CASP9, FASLG
9	Crohn's disease: Th1, Th17 or both? The change of a p aradigm: new immunological and genetic insights implicate Th17 cells in the pat hogenesis of Crohn's disease. (19592695)	Brand S.	2009	STAT3, CCR6, IL12B
10	Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn's disease stricture formation. (18635600)	Floer M.... Rafiee P.	2008	MSH2
11	Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. (18305068)	Simms L.A.... Radford-Smith G.L.	2008	VIL1, NOD2, DEFA5
12	Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease. (18425803)	Hosomi S.... Arakawa T.	2008	GHSR, GHRL
13	Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease. (18355814)	Zeissig S.... Schulzke J.D.	2008	SCNN1A
14	Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. (18022867)	Schmechel S.... Brand S.	2008	NOD2, IL23R, IL22
15	Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population. (18213697)	Hume G.E.... Radford-Smith G.L.	2008	TLR4, TLR5, NOD2
16	NOD2 engagement induces proinflammatory cytokine production, but not apoptosis, in leukocytes isolated from patients with Crohn's disease. (19103524)	Bodar E.... Van der Meer J.W.	2008	NOD2
17	Disease Behavior in Children with Crohn's Disease: The Effect of Disease Duration, Ethnicity, Genotype, and Phenotype. (18594982)	Shaoul R.... Levine A.	2008	NOD2
18	Increase in substance P precursor mRNA in noninflamed small-bowel sections in patients with Crohn's disease. (17368292)	Michalski C.W.... Friess H.	2007	TACR1
19	Vascular changes in ulcerative colitis and LeA9niowski-Crohn's disease. (17585538)	Zurawski J.... Majewski P.	2007	ICAM1
20	Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease. (17660460)	Lewis C.M.... Marteau T.M.	2007	NOD2
21	Evaluation of the interleukin-23 receptor gene coding variant R381Q in pediatric and adult Crohn disease. (18030204)	Leshinsky-Silver E.... Levine A.	2007	IL23R
22	Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease. (17476680)	De Ridder L.... Stokkers P.C.	2007	TLR4, SLC22A5, NOD2
23	The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. (17446213)	Glas J.... Weiss E.H.	2007	HLA-G
24	Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. (16917230)	Fakhoury M.... Jacqz-Agrain E.	2006	CYP3A4
25	Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn's disease: regulation by steroid treatment. (16911685)	Schaffler A.... Herfarth H.	2006	CCL5, IL10
26	Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism. (16118351)	Middel P.... Radzun H.J.	2006	CCL21, CCR7, CCL19
27	Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease. (16838391)	Beddy D.... O'Connell P.R.	2006	CTGF
28	Polymorphism in IgG Fc receptor gene FCGR3A and response to infliximab in Crohn's disease: a subanalysis of the ACCENT I study. (17108815)	Louis E.J.... Colombel J.F.	2006	FCGR3A
29	Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. (15674109)	Schmidt C.... Stallmach A.	2005	EBI3, IL27
30	Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene. (16097053)	Machida H.... Wen C.Y.	2005	NAT2, UGT1A7
31	CARD15 polymorphisms are associated with anti-Saccharomyces cerevisiae antibodies in caucasian Crohn's disease patients. (15807862)	Cruyssen B.V.... De Keyser F.	2005	NOD2
32	Serum osteoprotegerin is increased in Crohn's disease: a population-based case control study. (15803021)	Bernstein C.N.... Leslie W.D.	2005	TNFRSF11B, TNFSF11
33	Anti-inflammatory role of interleukin-15 in Crohn's disease. (15735428)	Silva M.A.... Seidman E.G.	2005	TNF, IFNG, IL15
34	The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort. (16133971)	Karban A.... Eliakim R.	2005	NOD2
35	Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease. (15472511)	Smith B.R.... Satsangi J.	2004	NOD2
36	NOD2/CARD15 mutations and genotype-phenotype correlations in patients with Crohn's disease. Hungarian multicenter study (15320482)	Lakatos L.... Szalay F.	2004	NOD2
37	Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn's disease. (15058523)	Thomas C.W.... Sandborn W.J.	2004	TNF
38	Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease. (15352908)	Franchimont N.... Louis E.	2004	CD36, BGLAP
39	Functional variants of OCTN cation transporter genes are associated with Crohn disease. (15107849)	Peltekova V.D.... Siminovitch K.A.	2004	SLC22A5, NOD2, SLC22A4
40	How future tumor necrosis factor antagonists and othe r compounds will meet the remaining challenges in Crohn's disease. (15583528)	Sandborn W.J.	2004	TNF
41	Octreotide for enterocutaneous fistulas of Crohn's disease. (14532930)	Lavy A.... Yasin K.	2003	SST
42	Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease. (12192200)	Regueiro M.... Mardini H.	2002	TPMT
43	Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement. (12492197)	Okazawa A.... Hibi T.	2002	LPL, IL18, IL12RB2
44	Association of susceptibility locus for inflammatory bowel disease on chromosome 16 with both ulcerative colitis and Crohn's disease. (11318544)	Farmer M.... Galandiuk S.	2001	NOD2
45	Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease? (11247890)	Schoon E.J.... Stockbrugger R.W.	2001	BGLAP
46	Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease. (10466882)	Esaki M.... Fujishima M.	1999	HSPA1B
47	Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. (7657114)	Mantyh C.R.... Pappas T.N.	1995	TACR1
48	Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn's disease. (7907543)	Baca-Estrada M.E.... Croitoru K.	1994	HSPD1
49	Report of a case of Crohn's disease associated with hyper-creatine phosphokinase-emia. (1803046)	Hayashi K.... Hirata I.	1991	PIK3C2A
50	Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin. (2370014)	Brynskov J.... Tvede N.	1990	IL2, IL2RB

Genes related to crohn's disease according to GeneCards:

(show top 50)    (show all 662)

id	Symbol	Description	Score	GeneCards Section Context
1	NOD2	nucleotide-binding oligomerization domain containing 2	11.1	Publications, Summaries
2	IRGM	immunity-related GTPase family, M	11.0	Publications, Summaries
3	UBE4A	ubiquitination factor E4A	11.0	Publications, Summaries
4	IL18BP	interleukin 18 binding protein	11.0	Publications, Summaries
5	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications, Summaries
6	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications, Summaries
7	HP	haptoglobin	11.0	Publications, Summaries
8	SAA1	serum amyloid A1	11.0	Summaries
9	SLC22A4	solute carrier family 22 (organic cation/ergothioneine transporter), member 4	11.0	Publications, Expressions
10	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	11.0	Publications, Orthologs
11	SLC22A5	solute carrier family 22 (organic cation/carnitine transporter), member 5	11.0	Publications, Expressions
12	IL23R	interleukin 23 receptor	11.0	Publications
13	ANAPC13	anaphase promoting complex subunit 13	11.0	Publications
14	CENPW	centromere protein W	11.0	Publications
15	PHOX2B	paired-like homeobox 2b	11.0	Publications
16	HIST1H1D	histone cluster 1, H1d	11.0	Publications
17	IHH	Indian hedgehog	11.0	Publications
18	PTGER4	prostaglandin E receptor 4 (subtype EP4)	11.0	Publications
19	BSN	bassoon (presynaptic cytomatrix protein)	11.0	Publications
20	CEP63	centrosomal protein 63kDa	11.0	Publications
21	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	11.0	Publications
22	LBP	lipopolysaccharide binding protein	11.0	Publications
23	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	11.0	Publications
24	TNF	tumor necrosis factor	11.0	Publications
25	C6orf106	chromosome 6 open reading frame 106	11.0	Publications
26	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
27	HHIP	hedgehog interacting protein	11.0	Publications
28	LIN28B	lin-28 homolog B (C. elegans)	11.0	Publications
29	ZBTB38	zinc finger and BTB domain containing 38	11.0	Publications
30	ZNF678	zinc finger protein 678	11.0	Publications
31	IL10	interleukin 10	11.0	Publications
32	PAX5	paired box 5	11.0	Publications
33	SPAG17	sperm associated antigen 17	11.0	Publications
34	STAT5B	signal transducer and activator of transcription 5B	11.0	Publications
35	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0	Publications
36	CDK6	cyclin-dependent kinase 6	11.0	Publications
37	IL15	interleukin 15	11.0	Publications
38	IL1B	interleukin 1, beta	11.0	Publications
39	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
40	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0	Publications
41	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
42	ALB	albumin	11.0	Publications
43	CD44	CD44 molecule (Indian blood group)	11.0	Publications
44	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
45	IBD15	Inflammatory bowel disease-15	10.9	Publications
46	IBD18	Inflammatory bowel disease-18	10.9	Publications
47	IBD4	inflammatory bowel disease 4	10.9	Publications
48	IBD6	inflammatory bowel disease 6	10.9	Publications
49	IBD5	inflammatory bowel disease 5	10.9	Publications
50	OCTN3	organic cation transporter 3	10.9	Publications

Pathways related to crohn's disease according to GeneDecks:

(show top 50)    (show all 157)

id	Pathway	Score	Top Affiliating Genes
1	Antioxidant Action of Vitamin-C36	17.7	NCF4, MYO9B, BMP6, JUN, JAK2, CD4
2	p38 Signaling36	17.2	BMP6, MST1R, CD4, CD80, FGF2, FGF7
3	Akt Signaling36	17.0	MST1R, CD4, CD80, ITGAL, ITGAM, ITGAX
4	Immune System38	16.7	SH2B1, NCR2, REL, KIR2DL1, KIR2DL3, KIR2DL2
5	Molecular Mechanisms of Cancer36	15.9	BMP6, BCL2L1, CFLAR, JUN, CD4, CD80
6	Transendothelial Migration of Leukocytes36	15.5	NCF4, MYO9B, CLDN2, CLDN4, CLDN5, CLDN11
7	MAPK Family Pathway36	14.8	BMP6, JUN, CD4, CD80, FGF2, FGF7
8	MIF Mediated Glucocorticoid Regulation36	14.8	BMP6, CD14, CD80, MIF, IL10, IL11
9	all-trans-Retinoic Acid Signaling in Brain36	14.8	BMP6, RARG, CD80, IL10, IL11, IL12A
10	MIF Regulation of Innate Immune Cells36	14.6	BMP6, JUN, CD14, CD80, MIF, IL10
11	JAK-STAT Pathway36	14.3	BMP6, UBC, MST1R, JUN, JAK2, CD4
12	Glucocorticoid Receptor Signaling36	14.3	BMP6, JUN, CD4, CD80, IL10, IL10RA
13	ERK Signaling36	14.0	BMP6, LAT, MST1R, CD80, ITGA4, ITGA5
14	Endothelin-1 Signaling Pathway36	13.8	BMP6, MST1R, CD80, IL10, IL11, IL12A
15	Chemokine signaling pathway20	13.6	PARD3, XCL1, JAK2, IL8, MAPK1, CCL7
16	Chemokine Signaling36	13.6	XCL1, JUN, JAK2, IL8, MAPK8, MAPK1
17	TGF-Beta Pathway36	13.4	BMP6, JUN, CD4, CD80, CDH1, FGF2
18	Cell adhesion molecules (CAMs)20	13.2	SELL, CLDN2, CLDN4, CLDN5, CLDN11, CLDN8
19	Jak-STAT signaling pathway20	13.2	BCL2L1, LEP, JAK2, IL10, IL10RA, IL10RB
20	IL-6 Pathway36	13.0	BMP6, CD80, IL10, IL11, IL12A, IL12B
21	NF-kappaB Signaling3	13.0	REL, IRF1, IRF4, IRF5, IL1B, FAS
22	TNF Superfamily Pathway36	12.8	JUN, MAPK8, MAP3K7, IKBKE, IKBKG, CASP1
23	Toll-like receptor signaling pathway20	12.8	LBP, JUN, CD86, CD14, CD80, CD40
24	NF-KappaB Family Pathway36	12.7	REL, BMP6, BCL3, FGF2, FGF7, IL1A
25	Cytokine production by Th17 cells in CF (Mouse model)41	12.6	REL, LBP, CFTR, JAK2, CD14, FOXP3
26	NFAT Signaling and Lymphocyte Interactions36	12.6	BMP6, CD4, CD80, IL11, IL12A, IL12B
27	Hematopoietic cell lineage20	12.5	CD24, CD36, CD14, CD59, CD4, CD19
28	THC Differentiation Pathway36	12.5	CD86, IL10, IL10RA, IL10RB, IL12A, IL12B
29	Intestinal immune network for IgA production20	12.5	PIGR, CD86, CD40LG, CD80, CD40, ITGA4
30	TRAF Pathway36	12.4	UBC, JUN, IL12A, IL12B, IL1A, IL1B
31	Natural killer cell mediated cytotoxicity20	12.3	NCR1, NCR2, KIR2DL1, KIR2DL3, KIR2DL2, LAT
32	UPA-UPAR Pathway36	12.0	VTN, SERPINE1, JUN, JAK2, ITGA4, ITGA5
33	Immune response_IL-12 signaling pathway41	12.0	UBC, JAK2, IRF1, IRF4, IL12A, IL12B
34	Immune response_Bacterial infections in normal airways41	11.9	REL, LBP, CFTR, CD14, IRF1, IL1B
35	Type I diabetes mellitus20	11.8	CD86, CD80, GZMB, IL12A, IL12B, IL1A
36	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.8	GZMB, IL12B, IL17A, IL17F, IL1B, IL21
37	Leishmaniasis20	11.8	NCF4, JUN, JAK2, ITGA4, ITGAM, ITGB2
38	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	11.7	VDR, BGLAP, JUN, CDX2, IL1A, IL1B
39	Allograft rejection20	11.6	CD86, CD40LG, CD80, CD40, GZMB, IL10
40	Graft-versus-host disease20	11.6	KIR2DL1, KIR2DL3, KIR2DL2, CD86, CD80, IL1A
41	Bacterial infections in CF airways41	11.5	REL, MUC1, LBP, CFTR, IRF1, IL1R1
42	Immune response IL-22 signaling pathway10	11.5	BCL2L1, JUN, JAK2, CD86, CD4, IL10RB
43	Immune response_IL-22 signaling pathway41	11.5	BCL2L1, JUN, JAK2, CD86, CD4, IL10RB
44	Cytokine Network36	11.4	IL10, IL12A, IL12B, IL13, IL15, IL16
45	Immune response MIF in innate immunity response10	11.4	LBP, JUN, CD14, MIF, IL1B, IL6
46	Immune response_MIF in innate immunity response41	11.4	LBP, JUN, CD14, MIF, IL1B, IL6
47	Chagas disease (American trypanosomiasis)20	11.4	SERPINE1, CFLAR, JUN, IL10, IL12A, IL12B
48	Autoimmune thyroid disease20	11.2	CD86, CD40LG, CD80, CD40, GZMB, IL10
49	Immune response_IL-1 signaling pathway41	11.2	SERPINE1, UBC, JUN, IRF1, IL1A, IL1B
50	Pathways in cancer20	9.2	VEGFA, BCL2L1, MSH2, JUN, CDH1, ITGAV

Compounds related to crohn's disease according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	lipid32	22.1	PIK3C2A, PI3, NCF4, RETN, CNR1, KIR2DL1
2	nitric oxide32 9 18 9	21.7	PI3, KLF4, REL, RETN, SELE, SERPINA1
3	oxygen32 18	18.5	PIK3C2A, PI3, NCF4, SERPINA1, BLVRB, BLZF1
4	estrogen32	15.4	RETN, GCG, SERPINC1, SERPINA1, SERPINE1, VIP
5	superoxide32 18	15.7	PIK3C2A, PI3, NCF4, SELL, BLVRB, BLZF1
6	creatinine32	14.5	RETN, GCG, SELE, SELL, SERPINC1, SERPINA1
7	glucose32	14.0	REG3A, GCG, LMAN1, VAMP3, RARRES2, BLVRB
8	wortmannin32 42	14.9	PIK3C2A, PI3, VTN, GCG, VIM, MYLK3
9	mannose32	13.5	KIR2DL2, LMAN1, LGALS3, CIITA, CD209, CD79A
10	ethanol32 34 9 18 9	17.1	SERPINA1, BPI, MYLK3, BLVRB, CHAT, MUC1
11	nacl32	12.9	BLZF1, SCNN1A, S100A4, P2RX7, XCL1, MMP3
12	calcitriol32 42 9 18 9	16.8	VDR, BMP6, BGLAP, PAX5, LBP, S100A9
13	lactate32	12.7	PIK3C2A, VTN, GCG, SELE, SELL, VIM
14	estradiol32 9 18 9	15.5	SERPINE1, VIM, BLVRB, CHAT, UGT1A7, MUC1
15	butyrate32	12.5	KLF4, GCG, VIM, VDR, BMP6, BLZF1
16	dopamine32 9 18 9	15.3	GCG, SELE, VIP, BMP6, BLVRB, CIITA
17	1,25 dihydroxy vitamin d332	12.3	VDR, BMP6, BGLAP, S100A9, CDK6, CD14
18	homocysteine32 18	13.3	PIK3C2A, RETN, SELE, SERPINC1, SERPINE1, NAT2
19	hydrocortisone32 9 9	14.2	VIM, BMP6, BGLAP, MUC1, LCT, CD36
20	genistein32 9 18 9	15.2	GCG, SELE, SELL, SERPINE1, VIM, VEGFA
21	heparan sulfate32 18	13.1	VTN, SERPINC1, SERPINE1, VIM, LPL, BMP6
22	agarose32	12.1	SERPINA1, BLZF1, BCL2L1, MUC1, MUC2, LBR
23	methotrexate32 34 42 9 9	15.9	PIK3C2A, SELE, SERPINE1, VIM, NAT2, BMP6
24	chloroquine32 34 9 9	14.9	VTN, SERPINC1, BMP6, CIITA, B2M, CFTR
25	groalpha32	11.8	SELE, IL10, IL13, IL17A, IL18, IL1A
26	cytochalasin b32	11.7	VTN, VIM, MYLK3, MT-CYB, S100A9, MPO
27	matrigel32	11.7	VTN, SELE, SERPINE1, VIM, VEGFA, BMP6
28	mannitol32 9 9	13.6	GCKR, XDH, B2M, JAK2, CD40LG, CDH1
29	polysulfone32	11.4	SELL, BPI, LBP, B2M, CD14, ITGAM
30	thyroxine32 18	12.4	PIK3C2A, RETN, VIP, LPL, VDR, BGLAP
31	actinomycin d32	11.3	RETN, SELE, SERPINE1, VIM, VEGFA, VDR
32	citrate32	11.3	PIK3C2A, VDR, BLZF1, CFTR, CD79A, MKI67
33	agar32	11.3	VIM, MUC1, JAK2, CD40LG, CDH1, FN1
34	leflunomide32 9 9	13.3	MMP1, MMP3, IL13, IL15, IL18R1, IL1R1
35	amiloride32 9 9	13.2	VIP, SCNN1A, CFTR, CA2, ODC1, CTGF
36	valine32	11.2	VIM, VIP, LPL, MTHFR, MTR, SAA1
37	choline32 9 18 9	14.1	PIK3C2A, VIM, VIP, BLVRB, CHAT, MTHFR
38	aprotinin32 9 9	13.1	SERPINC1, VIP, MMP2, MMP9, FN1, FGA
39	ibmx32	11.0	GCG, VIP, LPL, CIITA, CFTR, ITGB2
40	fluvastatin32 34 9 9	13.9	PIK3C2A, SERPINE1, LPL, CD40, ITGAL, MMP1
41	n acetylcysteine32	10.8	SELE, SERPINC1, MUC5AC, CFTR, JAK2, CD79A
42	mg 13232 42	11.8	VDR, BLZF1, BCL2L1, UBE2L3, CFLAR, CFTR
43	vincristine32 34 9 9	13.8	ITGA4, FGF2, ANXA5, IFNA1, IFNB1, CALCA
44	imiquimod32 42 9 9	13.7	BMP6, IL10, IL12B, IL18, IL1A, IL1RAPL2
45	pmma32	10.7	VTN, BMP6, B2M, CD40LG, FN1, CCL5
46	prostaglandin f2alpha32	10.4	SERPINE1, VIP, LPL, CD44, MMP1, IL1A
47	formaldehyde32 18	11.4	SELE, SELL, VIM, BLVRB, BLZF1, LGALS3
48	rottlerin32 42	11.1	JUN, CDK6, CD36, CD40LG, ITGAM, IL6R
49	5fluorouracil32	9.6	GCG, SELE, VEGFA, VDR, BCL2L1, MUC1
50	irinotecan32 34 9 9	12.0	VEGFA, BCL2L1, UGT1A7, MTHFR, CFLAR, CDH1

Cellular components related to crohn's disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	22.1	PIK3C2A, CNR1, KIR2DL1, KIR2DL3, KIR2DL2, GCG
2	cytoplasm	GO:005737	21.5	PIK3C2A, REG3A, VIL1, VIM, BSN, VEGFA
3	extracellular region	GO:005576	18.5	PIGR, NDFIP1, REG4, RETN, VTN, GCG
4	extracellular space	GO:005615	17.9	REG3A, VTN, SFRP2, GCG, SELE, SERPINC1
5	integral to plasma membrane	GO:005887	17.4	PIGR, NCR1, NCR2, CNR1, KIR2DL1, KIR2DL3
6	cytosol	GO:005829	15.8	PIK3C2A, SH2B1, NCF4, REL, GCKR, VIM
7	external side of plasma membrane	GO:009897	13.8	SELL, SCNN1A, P2RX7, B2M, CD79A, CD36
8	cell surface	GO:009986	12.0	VEGFA, LPL, CD24, CD36, CD14, CD59
9	membrane raft	GO:045121	12.0	SELE, CLN3, LAT, P2RX7, JAK2, CD79A
10	Golgi lumen	GO:005796	10.9	BLZF1, MUC1, MUC12, MUC19, MUC2, MUC3A
11	platelet alpha granule lumen	GO:031093	10.1	SERPINA1, SERPINE1, VEGFA, FN1, FGA, FGB

Biological processes related to crohn's disease according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	17.6	NDFIP1, NCR1, NCR2, GCG, VDR, RASIP1
2	immune response	GO:006955	17.2	NCF4, KIR2DL1, KIR2DL3, VTN, BPI, BMP6
3	inflammatory response	GO:006954	16.9	SELE, BMP6, CHI3L1, S100A12, S100A9, P2RX7
4	innate immune response	GO:045087	15.3	BCL2L1, LGALS3, UBA7, UBC, LCN2, LBP
5	cell-cell signaling	GO:007267	14.3	SFRP2, S100A9, XCL1, CEACAM6, CD86, CD80
6	cytokine-mediated signaling pathway	GO:019221	14.0	CIITA, UBA7, UBC, B2M, JAK2, CD44
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.0	KLF4, SFRP2, SERPINE1, VEGFA, VDR, BMP6
8	chemotaxis	GO:006935	13.3	S100A9, FGF2, IL4, MAPK1, CCL7, CCR6
9	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	13.1	NDFIP1, REL, UBC, S100A12, S100A4, CFLAR
10	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.8	GCG, CHI3L1, CD44, MIF, FGF2, IL1A
11	positive regulation of interferon-gamma production	GO:032729	12.7	CD40LG, IL12A, IL12B, IL12RB1, IL12RB2, IL18
12	regulation of immune response	GO:050776	12.7	KIR2DL1, KIR2DL3, KIR2DL2, SELL, B2M, CD40LG
13	positive regulation of NF-kappaB transcription factor activity	GO:051092	12.7	UBC, CD40, IL1B, IL6, IL6R, MAP3K7
14	defense response to bacterium	GO:042742	12.6	BPI, S100A12, MICA, IL10, IFNB1, IFNG
15	positive regulation of JNK cascade	GO:046330	12.6	IL1A, IL1B, MAP3K7, MAP3K11, CCL21, CCR7
16	positive regulation of tumor necrosis factor production	GO:032760	12.6	LBP, JAK2, CD36, CD14, IL12B, IL18
17	positive regulation of inflammatory response	GO:050729	12.4	SERPINE1, JAK2, IL12B, IL15, IL18, IL1RL1
18	response to lipopolysaccharide	GO:032496	12.4	CNR1, SELE, SERPINA1, LBP, S100A9, P2RX7
19	apoptotic process	GO:006915	12.4	VIM, BCL2L1, UBC, LCN2, CFLAR, MSH2
20	positive regulation of interleukin-6 production	GO:032755	12.4	LBP, P2RX7, CD36, IL1A, IL1B, IL6
21	defense response to Gram-positive bacterium	GO:050830	12.3	LBP, P2RX7, CD36, IL12A, IL6, IL6R
22	interferon-gamma-mediated signaling pathway	GO:060333	12.2	CIITA, B2M, JAK2, CD44, IRF1, IRF4
23	cellular response to mechanical stimulus	GO:071260	12.1	CD40, IRF1, IL13, IL18, IL1B, FAS
24	anti-apoptosis	GO:006916	12.0	BCL2L1, MUC1, UBC, CFLAR, MPO, CD40LG
25	response to drug	GO:042493	12.0	SFRP2, LPL, BGLAP, CHAT, LCT, P2RX7
26	positive regulation of activated T cell proliferation	GO:042104	12.0	CD24, IL12B, IL12RB1, IL18, IL2, IL23A
27	positive regulation of interleukin-12 production	GO:032735	11.9	CD36, CD40LG, CD40, IL12B, IL23A, IL23R
28	negative regulation of inflammatory response	GO:050728	11.9	KLF4, NDFIP1, SERPINC1, SAA1, MEFV, IL2
29	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	11.9	BCL2L1, UBC, P2RX7, MEFV, MAP3K7, IKBKG
30	leukocyte migration	GO:050900	11.9	SELL, ITGA4, ITGA5, ITGAL, ITGAM, ITGAV
31	positive regulation of cell proliferation	GO:008284	11.8	SFRP2, VIP, VEGFA, BCL2L1, LEP, T
32	response to hypoxia	GO:001666	11.8	SERPINA1, VEGFA, LEP, CHAT, LCT, CD24
33	defense response to Gram-negative bacterium	GO:050829	11.8	SERPINE1, LBP, CD4, IL12B, IL23A, IL23R
34	negative regulation of growth of symbiont in host	GO:044130	11.8	LBP, CD36, IL10, IL12B, MBL2, IFNG
35	positive regulation of protein kinase B signaling cascade	GO:051897	11.8	CHI3L1, MST1R, IL26, ANGPT1, CCL21, CCR7
36	negative regulation of apoptotic process	GO:043066	11.7	GCG, SERPINE1, VEGFA, CLN3, BCL2L1, BCL3
37	acute-phase response	GO:006953	11.6	REG3A, SERPINA1, LBP, SAA1, FN1, IL1RN
38	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.6	XDH, JAK2, FASLG, FAS, CCK, IFNB1
39	negative regulation of smooth muscle cell proliferation	GO:048662	11.6	KLF4, IL12A, IL12B, IL15, ANG, IGFBP5
40	virus-host interaction	GO:019048	11.5	VIM, CFLAR, KAT5, CD209, CD86, CD80
41	positive regulation of interleukin-10 production	GO:032733	11.5	XCL1, CD40LG, CD83, IL12B, IL21, IL23A
42	response to ethanol	GO:045471	11.5	CNR1, BGLAP, CHAT, LCT, S100A9, MMP9
43	response to organic cyclic compound	GO:014070	11.5	SERPINA1, P2RX7, MSH2, JUN, CD83, IL1A
44	Toll signaling pathway	GO:008063	11.2	UBC, LBP, JUN, CD14, MAPK8, MAP3K7
45	elevation of cytosolic calcium ion concentration	GO:007204	11.2	SAA1, JAK2, CD24, FIS1, IL1B, IL2
46	blood coagulation	GO:007596	11.1	SH2B1, SELL, SERPINC1, SERPINA1, SERPINE1, VEGFA
47	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.1	VTN, VEGFA, JAK2, CD36, CD4, CD80
48	cellular response to lipopolysaccharide	GO:071222	11.1	SERPINE1, LBP, CD36, CD14, GSTP1, IL10
49	platelet activation	GO:030168	10.5	SERPINA1, SERPINE1, VEGFA, LAT, SAA1, CD36
50	platelet degranulation	GO:002576	10.4	SERPINA1, SERPINE1, VEGFA, CD36, ITGB3, FN1

Molecular functions related to crohn's disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	22.4	SYMPK, POU2F1, SLPI, SLC22A4, SLAMF1, SLC40A1
2	cytokine activity	GO:005125	13.5	FGF2, IL1A, IL1B, IL2, IL21, IL22
3	receptor binding	GO:005102	13.2	LPL, RARRES2, LBP, P2RX7, JAK2, ITGB2
4	receptor activity	GO:004872	12.5	TNFRSF6B, TNFRSF11B, TNFRSF10B, TNFRSF10A, ICAM1, TNFRSF9
5	chemokine activity	GO:008009	12.3	CCL19, CCL5, CXCL1, CXCL10, CXCL16, CXCL6
6	protein homodimerization activity	GO:042803	11.9	NOD1, NOS2, NFKB1, SHBG, CRP, SMAD3
7	heparin binding	GO:008201	11.3	CCL5, CTGF, CTSG, LTF, ABP1, ELANE
8	tumor necrosis factor receptor binding	GO:005164	11.3	TNFSF15, TNFSF18, TNFSF8, LTA, LTB, TNFSF14
9	growth factor activity	GO:008083	10.6	HBEGF, CTGF, F2, IGF1, IGF2, TGFA
10	hormone activity	GO:005179	10.4	PTH, SST, EDN1, TTR, POMC, NMB
11	protease binding	GO:002020	10.0	TP53, TNF, TNFRSF1A, ELANE, DPP4, ECM1