MCID: CRH001
MIFTS: 74

Crohn's Disease malady

Genetic diseases, Rare diseases, Gastrointestinal diseases categories
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Summaries for Crohn's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Crohn's Disease, also known as crohn disease, is related to ulcerative colitis and psoriasis. An important gene associated with Crohn's Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways is Leishmaniasis. The drugs azathioprine and thalidomide and the compounds peptidoglycan and il 10 have been mentioned in the context of this disorder. Affiliated tissues include intestine, skin and colon.

Disease Ontology:8 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference:21 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

NIH Rare Diseases:43 Crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the intestines. common signs and symptoms include abdominal pain and diarrhea. bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. other problems can include intestinal blockage and malnutrition. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. quitting smoking can also improve the symptoms of crohn’s disease. last updated: 11/15/2012

CDC:4 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Wikipedia:65 Crohn\'s disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel... more...

Aliases & Classifications for Crohn's Disease

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8Disease Ontology, 65Wikipedia, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

crohn's disease 8 65 43 21 34 31
crohn disease 8 20 21 62
ileitis 43 21 45 62
pediatric crohn's disease 8 43 62
crohn's disease of large bowel 8 62
granulomatous colitis 8 43
regional ileocolitis 8 62
enteritis 43 62
regional enteritis of small intestine with large intestine 8
regional enteritis of the large bowel 8
pediatric onset crohn's disease 43
crohn's disease of the ileum 62
crohn's disease, pediatric 43
enteritis, granulomatous 21
crohn's disease of colon 8
granulomatous enteritis 43
colitis, granulomatous 21
enteritis, regional 21
crohn's enteritis 21
regional colitis 8
regional ileitis 8
crohn's colitis 8
crohns disease 10
eleocolitis 8
ileocolitis 21
iieocolitis 62


External Ids:

Disease Ontology8 DOID:8778
NCIt40 C35210
ICD9CM27 555.0
ICD1025 K50, K50.9

Related Diseases for Crohn's Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to crohn's disease

Symptoms for Crohn's Disease

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Drugs & Therapeutics for Crohn's Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Crohn's Disease

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20GeneTests
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Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease20 NOD2

Anatomical Context for Crohn's Disease

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Sources:
31LifeMap Discovery™, 33MalaCards, 14FMA
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MalaCards organs/tissues related to Crohn's Disease:

33
Skin, Colon, Small intestine, Testes, Bone, T cells, Eye, Kidney, Monocytes, Endothelial, Bone marrow, Smooth muscle, Liver, B cells, Lymph node, Thyroid, Appendix, Whole blood, Myeloid, Lung, Pancreas, Tonsil, Skeletal muscle

FMA organs/tissues related to Crohn's Disease:

14
Intestine

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Crohn's Disease or affiliated genes

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Publications for Crohn's Disease

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52PubMed
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Articles related to Crohn's Disease:

(show top 50)    (show all 2229)
idTitleAuthorsYear
1
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. (23266558)
2013
2
The utility of platelet, mean platelet volume, and red cell distribution width in the diagnosis of active Crohn's disease and intestinal tuberculosis. (24252895)
2013
3
Mucosal barrier in ulcerative colitis and Crohn's disease. (23737764)
2013
4
Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn's disease: A meta-analysis. (24307809)
2013
5
Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease. (23749272)
2013
6
Incidence, clinical characteristics, long-term course, and comparison of progressive and nonprogressive cases of aphthous-type Crohn's disease: a single-center cohort study. (23751515)
2013
7
American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-I+ biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease. (24267475)
2013
8
Auricular pyoderma gangrenosum associated with Crohn's disease. (22585655)
2012
9
Crohn's disease and primary sclerosing cholangitis: a case report and review of the literature. (22892482)
2012
10
Has primary sclerosing cholangitis associated with Crohn's disease a better outcome? (22677115)
2012
11
Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients. (21688348)
2012
12
The cystic fibrosis F508del mutation in Crohn's disease. (21131241)
2011
13
Concurrent small bowel adenocarcinoma and carcinoid tumor in Crohn's disease--case report and literature review. (21939921)
2011
14
Gastrointestinal tuberculosis with anal and perianal involvement misdiagnosed as Crohn's disease for 15 years. (21479355)
2011
15
Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (20846217)
2010
16
Portal cavernoma in a patient with Crohn's disease associated with factor V Leiden mutation and antiphospholipid syndrome. (21188340)
2010
17
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. (18936107)
2009
18
Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. (19587699)
2009
19
Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population. (19276991)
2009
20
Mushroom intolerance: a novel diet-gene interaction in Crohn's disease. (19660151)
2009
21
Different regulation of eosinophil activity in Crohn's disease compared with ulcerative colitis. (18801925)
2008
22
Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients. (17879276)
2008
23
Increased subpopulations of CD16(+) and CD56(+) blood monocytes in patients with active Crohn's disease. (17260384)
2007
24
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis. (17877509)
2007
25
Analysis of soluble angiogenic factors in Crohn's disease: a preliminary study. (17980128)
2007
26
Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants. (17876878)
2007
27
Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. (17206716)
2007
28
CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease. (17504508)
2007
29
Influence of a nucleotide oligomerization domain 1 (NOD1) polymorphism and NOD2 mutant alleles on Crohn's disease phenotype. (17907287)
2007
30
Clinically active Crohn's disease in the presence of a low C-reactive protein. (16497618)
2006
31
The +1059G/C polymorphism in the C-reactive protein (CRP) gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn's disease. (16984505)
2006
32
TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease. (15937090)
2005
33
CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease. (15551253)
2004
34
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. (14561165)
2003
35
Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): results of a randomized, open-label, pilot study. (12534402)
2003
36
99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease. (12634965)
2003
37
Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case. (12032437)
2002
38
Seroreactivities against Saccharomyces cerevisiae and Mycobacterium avium subsp. paratuberculosis p35 and p36 antigens in Crohn's disease patients. (12353858)
2002
39
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. (11788561)
2002
40
Therapeutic inhibitors of tumor necrosis factor in Crohn's disease. (12498004)
2002
41
Thalidomide treatment for refractory Crohn's disease: a review of the history, pharmacological mechanisms and clinical literature. (11730158)
2001
42
Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission. (11008719)
2000
43
Beta2 integrin/ICAM expression in Crohn's disease. (9473377)
1998
44
Mapping of a susceptibility locus for Crohn's disease on chromosome 16. (8587604)
1996
45
Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. (7523224)
1994
46
Anti-lactoferrin antibodies and other types of ANCA in ulcerative colitis, primary sclerosing cholangitis, and Crohn's disease. (8432453)
1993
47
Antibodies to cathepsin G in Crohn's disease. (1633838)
1992
48
T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. (2298368)
1990
49
Small bowel adenocarcinoma and Crohn's disease. (3818257)
1986
50
Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease. (6132589)
1983

Variations for Crohn's Disease

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Expression for genes affiliated with Crohn's Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Crohn's Disease

Search GEO for disease gene expression data for Crohn's Disease.

Pathways for genes affiliated with Crohn's Disease

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50PathCards, 30KEGG
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Pathways related to Crohn's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0NOD2, IL6, IRGM

Compounds for genes affiliated with Crohn's Disease

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank
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Compounds related to Crohn's Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1peptidoglycan45 2911.2NOD2, IL6
2il 104510.1NOD2, IL6
3infliximab45 51 1111.9NOD2, IL6

GO Terms for genes affiliated with Crohn's Disease

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16Gene Ontology
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Cellular components related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:03067010.2SLC11A1, IRGM

Biological processes related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell activationGO:05087110.4NOD2, IL6
2positive regulation of dendritic cell antigen processing and presentationGO:00260610.4SLC11A1, NOD2
3defense response to protozoanGO:04283210.4SLC11A1, IL6
4positive regulation of phagocytosisGO:05076610.3SLC11A1, NOD2
5defense response to Gram-negative bacteriumGO:05082910.3IL6, SLC11A1
6defense response to Gram-positive bacteriumGO:05083010.3NOD2, IL6
7response to lipopolysaccharideGO:03249610.3IL6, NOD2, SLC11A1
8positive regulation of interleukin-6 productionGO:03275510.2NOD2, IL6
9positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2NOD2, IL6
10positive regulation of epithelial cell proliferationGO:05067910.1IL6, NOD2
11inflammatory responseGO:0069549.7SLC11A1, IL6, IRGM

Products for genes affiliated with Crohn's Disease

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Sources for Crohn's Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet