MCID: CRH001
MIFTS: 78

Crohn's Disease malady

Gastrointestinal category

Summaries for Crohn's Disease

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Crohn's Disease, also known as crohn disease, is related to ulcerative colitis and hepatitis c. An important gene associated with Crohn's Disease is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Immune System and Leishmaniasis. The drugs azathioprine and thalidomide and the compounds epinephrine and vitamin d have been mentioned in the context of this disorder. Affiliated tissues include intestine, skin and liver, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference:21 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

NIH Rare Diseases:43 Crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the intestines. common signs and symptoms include abdominal pain and diarrhea. bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. other problems can include intestinal blockage and malnutrition. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. quitting smoking can also improve the symptoms of crohn’s disease. last updated: 11/15/2012

CDC:3 Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Wikipedia:64 Crohn\'s disease, also known as Crohn syndrome and regional enteritis, is a type of inflammatory bowel... more...

Aliases & Classifications for Crohn's Disease

Sources:
8Disease Ontology, 64Wikipedia, 43NIH Rare Diseases, 21Genetics Home Reference, 34MedlinePlus, 31LifeMap Discovery™, 20GeneTests, 61UMLS, 45Novoseek, 10DISEASES, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

crohn's disease 8 64 43 21 34 31
crohn disease 8 20 21 61
ileitis 43 21 45 61
crohn's disease of large bowel 8 61
pediatric crohn's disease 8 61
granulomatous colitis 8 43
regional ileocolitis 8 61
enteritis 43 61
regional enteritis of small intestine with large intestine 8
regional enteritis of the large bowel 8
pediatric onset crohns disease 43
crohn's disease of the ileum 61
crohns disease, pediatric 43
pediatric crohns disease 43
enteritis, granulomatous 21
crohn's disease of colon 8
granulomatous enteritis 43
colitis, granulomatous 21
enteritis, regional 21
crohn's enteritis 21
regional colitis 8
regional ileitis 8
crohn's colitis 8
crohns disease 10
eleocolitis 8
ileocolitis 21
iieocolitis 61


External Ids:

Disease Ontology8 DOID:8778
NCIt40 C35210
ICD9CM27 555.0
ICD1025 K50, K50.9

Related Diseases for Crohn's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 483)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis30.7IBD5, TNFSF15, DEFA5, IL6, IL23R, SLC11A1
2hepatitis c30.4HP
3adenocarcinoma30.4CD44
4tuberculosis30.3IRGM, HP, SLC11A1, NOD2
5arthritis30.1SAA1, CD44, HP, IL6, SLC11A1, NOD2
6deficiency anemia30.1SLC11A1, IL6, HP, SAA1
7colorectal cancer29.8NOD2, CD44
8hemochromatosis29.8HP
9asthma29.6IL12RB2, SLC11A1, NOD2
10short bowel syndrome10.5
11short syndrome10.5
12hirschsprung's disease10.4
13typhoid fever10.4
14hepatitis e10.3
15pouchitis10.3
16acute diarrhea10.3
17reactive arthritis10.3
18gastric outlet obstruction10.3
19hermansky-pudlak syndrome10.3
20small bowel adenocarcinoma10.2
21hepatitis a10.2
22steatorrhea10.2
23paratyphoid fever10.2
24intestinal tuberculosis10.1
25vasculitis10.1
26nutrition disease10.1
27campylobacteriosis10.1
28exocrine pancreatic insufficiency10.1
29clostridium difficile10.1
30myxozoa10.1
31hepatitis c virus10.1
32oophoritis10.1
33hypophosphatemia10.1
34anorexia nervosa10.1
35agammaglobulinemia10.1
36spondyloarthropathy10.1
37substance abuse10.1
38thoraco abdominal enteric duplication10.1
39warfarin resistance10.1
40ileus10.1
41anisakiasis10.1
42intestinal schistosomiasis10.1
43mesenteric lymphadenitis10.1
44acute monocytic leukemia10.1
45chronic granulomatous disease10.1
46hypercalcemia10.1
47retinal vasculitis10.1
48acute leukemia10.1
49spondylarthropathy10.1
50crohn disease-associated growth failure10.1

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to crohn's disease

Clinical Features for Crohn's Disease

Drugs & Therapeutics for Crohn's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Crohn's Disease

Sources:
20GeneTests
See all sources

Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease20 NOD2

Anatomical Context for Crohn's Disease

Sources:
31LifeMap Discovery™, 33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Crohn's Disease:

33
Skin, Liver, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Thymus, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Placenta, Monocytes, T cells, B cells, Endothelial, Appendix

FMA organs/tissues related to Crohn's Disease:

14
Intestine

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Crohn's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Crohn's Disease

Sources:
51PubMed
See all sources

Articles related to Crohn's Disease:

(show top 50)    (show all 1094)
idTitleAuthorsYear
1
Clinical features and predictors of clinical outcomes in Korean patients with Crohn's disease: A Korean Association for the Study of Intestinal Diseases multicenter study. (23981141)
2014
2
Cannabis Use Provides Symptom Relief in Patients with Inflammatory Bowel Disease but Is Associated with Worse Disease Prognosis in Patients with Crohn's Disease. (24407485)
2014
3
An envirogenomic signature is associated with risk of IBD-related surgery in a population-based Crohn's disease cohort. (23818124)
2013
4
Development of psoriasis scalp with alopecia during treatment of Crohn's disease with infliximab and rapid response to both diseases to ustekinumab. (24174369)
2013
5
Surgical cost of care in Crohn's disease. (24133109)
2013
6
Mortality and causes of death in Crohn's disease: results from 20 years of follow-up in the IBSEN study. (23744613)
2013
7
How early to take arms against a sea of troubles? The case for aggressive early therapy in Crohn's disease to prevent fibrotic intestinal strictures. (23880128)
2013
8
Contrast-enhanced MR enterography as a stand-alone tool to evaluate Crohn's disease in a paediatric population. (23796211)
2013
9
Five-year mortality in colorectal cancer patients with ulcerative colitis or Crohn's disease: a nationwide population-based cohort study. (23435402)
2013
10
Cancer of the small intestine in patients with Crohn's disease. (23780989)
2013
11
Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease. (22749932)
2012
12
Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease. (22234764)
2011
13
Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease. (21725903)
2011
14
The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype. (20428899)
2010
15
Crohn's disease during the course of multiple sclerosis: role of interferon-beta therapy]. (19201069)
2009
16
Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population. (19700857)
2009
17
Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease. (18825772)
2008
18
Clinical and genetic factors associated with sacroiliitis in Crohn's disease. (17725592)
2008
19
Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: is there a role for defensins? (18397186)
2008
20
JC viral loads in patients with Crohn's disease treated with immunosuppression: can we screen for elevated risk of progressive multifocal leukoencephalopathy? (18436577)
2008
21
Effects of infliximab and parenteral nutrition on albumin and fibrinogen synthesis rates in pediatric Crohn disease. (18979581)
2008
22
Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial. (18440315)
2008
23
Anti-Saccharomyces cerevisiae antibody is not useful to differentiate between Crohn's disease and intestinal tuberculosis in India. (17699989)
2007
24
Pure ileal Crohn's disease without colonic involvement after a long ileo-colonic anastomosis (Lester Martin Procedure) for Hirschsprung's disease: an argument favoring a specific sensitivity of the ileum in a subset of patients with Crohn's disease. (17206715)
2007
25
Tumor necrosis factor-alpha haplotype is strongly associated with bone mineral density in patients with Crohn's disease. (17565648)
2007
26
Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn's disease. (16911686)
2006
27
Small bowel adenocarcinoma in Crohn's disease: a case report and review of literature. (16534894)
2006
28
The potential role of serology in diagnosing chronic lymphogranuloma venereum (LGV): a case of LGV mimicking Crohn's disease. (16581740)
2006
29
Correlated expression of high-sensitivity C-reactive protein in relation to disease activity in inflammatory bowel disease: lack of differences between Crohn's disease and ulcerative colitis. (16837810)
2006
30
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. (15910952)
2005
31
A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease. (16164701)
2005
32
Response to Dr Waldum's letter regarding 'Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease'. (16093882)
2005
33
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease. (15539413)
2005
34
Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease. (15472511)
2004
35
NOD2/CARD15 genotype and phenotype differences between Ashkenazi and Sephardic Jews with Crohn's disease. (15180737)
2004
36
Small bowel adenocarcinoma at a strictureplasty site in a patient with Crohn's disease: report of a case. (15037927)
2004
37
Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease. (14750643)
2003
38
No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease. (14571275)
2003
39
Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: a prospective cohort study. (12851868)
2003
40
Low serum concentrations of insulin-like growth factor-I in children with active Crohn disease: effect of enteral nutritional support and glutamine supplementation. (12523592)
2002
41
A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. (12190096)
2002
42
CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. (11487533)
2001
43
Frequently relapsing Crohn's disease is characterized by persistent elevation in interleukin-6 and soluble interleukin-2 receptor serum levels during remission. (11008719)
2000
44
C1 inhibitor deficiency and angioedema of the small intestine masquerading as Crohn's disease. (10799090)
2000
45
Crohn's disease and the Melkersson-Rosenthal syndrome. (10203435)
1999
46
Simultaneous occurrence of hereditary angioneurotic edema and Crohn disease]. (9613166)
1998
47
Mapping of a susceptibility locus for Crohn's disease on chromosome 16. (8587604)
1996
48
Soluble interleukin-2 receptor as a marker of lymphocyte activation in childhood Crohn's disease. (1791504)
1991
49
Pernicious anemia caused by Crohn's disease of the stomach. (433904)
1979
50
Granulomatous oophoritis and salpingitis associated with Crohn's disease of the appendix. (1146908)
1975

Genetic Variations for Crohn's Disease

Expression for genes affiliated with Crohn's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Crohn's Disease

Search GEO for disease gene expression data for Crohn's Disease.

Pathways for genes affiliated with Crohn's Disease

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Crohn's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5IL6, CD44, DEFA5, DEFA6, SAA1, UBE4A
2
Hide members
11.3NOD2, IL23R, IL6, IL12RB2, IRGM
311.1TNFSF15, ATG16L1, CD44, IL6
4
Hide members
10.8SLC22A5, SLC22A4
510.8DEFA6, DEFA5

Compounds for genes affiliated with Crohn's Disease

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1epinephrine45 11 2413.4SLC22A5, IL6, HP, CD44
2vitamin d4511.3SLC11A1, IL6, HP, CD44
3hbd24511.3IL6, DEFA5, DEFA6
4endotoxin4511.1IL18BP, SAA1
5cirazoline4511.1SLC22A4, SLC22A5
6moxa4511.1SLC22A4, SLC22A5
7tiotropium50 45 29 1114.1SLC22A5, SLC22A4
8ipratropium bromide45 1112.1SLC22A4, SLC22A5
9Penicillin G1111.0SLC22A4, SLC22A5
10tenidap45 2912.0SAA1, IL6
11moxonidine4511.0SLC22A4, SLC22A5
12Aminohippurate1111.0SLC22A4, SLC22A5
13ulinastatin4510.9HP, IL6
14procainamide45 1111.9SLC22A4, SLC22A5
15mepyramine45 1111.8SLC22A4, SLC22A5
16ofloxacin45 2 1112.8SLC22A5, SLC22A4
17L-Carnitine11 2411.7SLC22A5, SLC22A4
18prednisolone45 29 1112.7NOD2, IL6, CD44

GO Terms for genes affiliated with Crohn's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4IL6, TNFSF15, DEFA6, DEFA5, HP, IL18BP
2autophagic vacuole membraneGO:00042110.8ATG16L1, IRGM
3endocytic vesicle lumenGO:07168210.5HP, SAA1

Biological processes related to Crohn's Disease according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:03249611.8NOD2, SLC11A1, IL23R, IL6, IL18BP, IL12RB2
2defense response to bacteriumGO:04274211.6DEFA6, DEFA5, HP, SLC11A1, NOD2
3innate immune responseGO:04508711.3SAA1, IRGM, DEFA6, DEFA5, NOD2
4defense response to Gram-negative bacteriumGO:05082911.3IL6, IL23R, SLC11A1
5positive regulation of interferon-gamma productionGO:03272911.3SLC11A1, IL23R, IL12RB2
6acute-phase responseGO:00695311.2SAA1, HP, IL6
7inflammatory responseGO:00695411.2IRGM, IL6, IL23R, SLC11A1
8positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.2NOD2, IL6, CD44
9quaternary ammonium group transportGO:01569711.1SLC22A5, SLC22A4
10positive regulation of ERK1 and ERK2 cascadeGO:07037411.1NOD2, IL6, CD44
11carnitine transportGO:01587911.1SLC22A5, SLC22A4
12positive regulation of B cell activationGO:05087111.1NOD2, IL6
13positive regulation of dendritic cell antigen processing and presentationGO:00260611.0SLC11A1, NOD2
14positive regulation of T-helper 1 type immune responseGO:00282711.0SLC11A1, IL23R
15positive regulation of interleukin-17 productionGO:03274011.0IL23R, NOD2
16killing of cells of other organismGO:03164010.9DEFA5, DEFA6
17response to interferon-gammaGO:03434110.8SLC11A1, IL23R
18defense response to protozoanGO:04283210.7SLC11A1, IL6
19defense response to fungusGO:05083210.5DEFA5, DEFA6

Molecular functions related to Crohn's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1quaternary ammonium group transmembrane transporter activityGO:01565110.8SLC22A5, SLC22A4
2carnitine transmembrane transporter activityGO:01522610.5SLC22A5, SLC22A4

Products for genes affiliated with Crohn's Disease

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Sources for Crohn's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet