MCID: CRH001
MIFTS: 75

Crohn's Disease malady

Categories: Rare diseases, Gastrointestinal diseases, Infectious diseases, Genetic diseases

Aliases & Classifications for Crohn's Disease

Aliases & Descriptions for Crohn's Disease:

Name: Crohn's Disease 38 12 71 50 25 41 14
Crohn Disease 12 24 25 14 69
Pediatric Crohn's Disease 12 50 69
Enteritis 50 52 69
Ileitis 50 25 69
Crohn's Disease of Large Bowel 12 69
Granulomatous Colitis 12 50
Pediatric Onset Crohn's Disease 50
Crohn's Disease, Pediatric 50
Crohn's Disease of Colon 12
Enteritis, Granulomatous 25
Granulomatous Enteritis 50
Colitis, Granulomatous 25
Enteritis, Regional 25
Regional Enteritis 69
Crohn's Enteritis 25
Ileocolitis 25
Iieocolitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8778
ICD9CM 35 555.1
MeSH 42 D003424
UMLS 69 C0156147

Summaries for Crohn's Disease

MedlinePlus : 41 crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to collagenous colitis and ileitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are hematopoietic system and cardiovascular system

NIH Rare Diseases : 50 crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the gastrointestinal (gi) tract. common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. complications of crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. last updated: 3/15/2016

Genetics Home Reference : 25 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

Wikipedia : 71 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Crohn's Disease

Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Related Disease Score Top Affiliating Genes
1 collagenous colitis 29.6 ATG16L1 IL23R IRGM MUC2 NOD2 TNF
2 ileitis 12.4
3 thoraco abdominal enteric duplication 11.9
4 cryptogenic multifocal ulcerous stenosing enteritis 11.9
5 enteric pattern testicular yolk sac tumor 11.8
6 inflammatory bowel disease 1 11.6
7 trichohepatoenteric syndrome 1 11.5
8 crohn's colitis 11.3
9 inflammatory bowel disease 25, early onset, autosomal recessive 10.8
10 inflammatory bowel disease 17, protection against 10.8
11 inflammatory bowel disease 10 10.8
12 inflammatory bowel disease 19 10.8
13 inflammatory bowel disease 13 10.8
14 inflammatory bowel disease 14 10.8
15 inflammatory bowel disease 28, early onset, autosomal recessive 10.8
16 bile acid malabsorption, primary 10.7
17 6-mercaptopurine sensitivity 10.7
18 hypomagnesemia 1, intestinal 10.7
19 autoimmune disease 6 10.7
20 benign eccrine breast spiradenoma 10.3 NOD2 SLC11A1 TNF
21 endobronchial leiomyoma 10.3 IL23R NOD2 TNF
22 parkinson disease 11 10.2 ATG16L1 IL23R NOD2 SLC22A4 TNF
23 pseudohypoaldosteronism, type iid 10.2 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
24 dermatosis papulosa nigra 10.2 NOD2 TNF
25 molybdenum cofactor deficiency a 10.2 IL23R NOD2 TNF
26 uterine ligament clear cell adenocarcinoma 10.2 ATG16L1 IL23R IRGM NOD2 TNF
27 deafness, autosomal recessive 67 10.2 IL12RB2 NOD2 SLC11A1 TNF
28 goodpasture syndrome 10.2 IL12RB2 IL23R NOD2 TNF
29 periarthritis 10.2 HP SLC11A1 TNF
30 wagr syndrome 10.2 ATG16L1 IL23R IRGM MUC2 NOD2 TNF
31 atrial septal defect 6 10.2 IL12RB2 IL18RAP NOD2 SLC11A1 TNF
32 amyotrophic lateral sclerosis type 5 10.2 NOD2 TNF
33 glycogen storage disease ix 10.1 ATG16L1 IL18RAP IL23R ITGA4 NOD2 SLC22A4
34 colitis 10.1
35 ulcerative colitis 10.0
36 jejunoileitis 9.9
37 gastroduodenal crohn's disease 9.9
38 pouchitis 9.9
39 purpura 9.9
40 mesenteric lymphadenitis 9.8
41 lymphadenitis 9.8
42 gastritis 9.7
43 anisakiasis 9.7
44 appendicitis 9.7
45 interstitial nephritis 9.6
46 granulomatous hepatitis 9.6
47 protein-losing enteropathy 9.6
48 pancreatitis 9.6
49 adenoma 9.6
50 fabry disease 9.6

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease

Symptoms & Phenotypes for Crohn's Disease

UMLS symptoms related to Crohn's Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IL23R ITGA4 MUC2 NOD2 SLC11A1 TNF
2 cardiovascular system MP:0005385 10.06 ADAM17 ATG16L1 FGFR1OP HP IL12RB2 ITGA4
3 homeostasis/metabolism MP:0005376 10.03 ADAM17 ATG16L1 FGFR1OP HP IL12RB2 IL18RAP
4 digestive/alimentary MP:0005381 10.02 ADAM17 ATG16L1 IL12RB2 IL23R MUC2 NOD2
5 immune system MP:0005387 9.97 ADAM17 ATG16L1 FGFR1OP HP IL12RB2 IL18RAP
6 mortality/aging MP:0010768 9.73 ADAM17 ATG16L1 FGFR1OP HP ITGA4 MUC2
7 neoplasm MP:0002006 9.1 HP IL12RB2 IL23R MUC2 SLC11A1 TNF

Drugs & Therapeutics for Crohn's Disease

Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 419)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
3
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
4
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
5
Rifabutin Approved Phase 4,Phase 3 72559-06-9 6323490
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
8
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
10
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
11
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
12
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
13
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
14
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
15
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
16
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
17
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
18
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
19
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
20
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
21
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
22
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
23
Bupropion Approved Phase 4,Phase 2,Phase 3 34841-39-9, 34911-55-2 444
24
Dopamine Approved Phase 4,Phase 2,Phase 3 51-61-6, 62-31-7 681
25
Dimenhydrinate Approved Phase 4 523-87-5 441281
26
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
27
Vedolizumab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 943609-66-3
28
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
31
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
32
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
33
Losartan Approved Phase 4 114798-26-4 3961
34
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
35
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
36
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
37
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
38
Thioguanine Approved Phase 4 154-42-7 2723601
39
Pantoprazole Approved Phase 4 102625-70-7 4679
40
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
41
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
42
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
43
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 50-14-6 5280793
44 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
46
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
47
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
48
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
49
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
50 Antibodies Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 1122)
id Name Status NCT ID Phase
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4
4 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4
5 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4
6 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
7 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4
8 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4
9 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4
12 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
13 Enhanced Algorithm for Crohn's Treatment Incorporating Early Combination Therapy Unknown status NCT01698307 Phase 4
14 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
15 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4
16 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
17 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
18 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
19 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
20 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4
21 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4
22 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
23 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4
24 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
25 Endoscopic Severity Score of Small Bowel Crohn's Disease With Wireless Capsule Endoscopy Completed NCT00492791 Phase 4
26 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
27 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4
28 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
29 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4
30 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4
31 The Crohn's Therapy, Resource, Evaluation, and Assessment Tool Registry Completed NCT00553176 Phase 4
32 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
33 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4
34 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4
35 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4
36 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4
37 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4
38 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
39 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
40 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4
41 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
42 An Observational Study of Lymphoma in Patients With Rheumatoid Arthritis or Crohn's Disease. Completed NCT00440817 Phase 4
43 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
44 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
45 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
46 Remicade Infusion Management Program Completed NCT00723905 Phase 4
47 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4
48 A Long-term Safety Study of Infliximab (Remicade) Completed NCT00261976 Phase 4
49 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4
50 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.

Genetic Tests for Crohn's Disease

Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease 24 NOD2

Anatomical Context for Crohn's Disease

MalaCards organs/tissues related to Crohn's Disease:

39
Colon, Small Intestine, Testes, T Cells, Bone, Skin, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

18
Intestine
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Crohn's Disease

Articles related to Crohn's Disease:

(show top 50) (show all 2733)
id Title Authors Year
1
Can Inspection of the Mouth Help Clinicians Diagnose Crohn's Disease? A Review. ( 28530005 )
2017
2
Accuracy of computed tomographic features in differentiating intestinal tuberculosis from Crohn's disease: a systematic review with meta-analysis. ( 28522943 )
2017
3
Defective ATG16L1-mediated removal of IRE1I+ drives Crohn's disease-like ileitis. ( 28082357 )
2017
4
Dietary Therapy with the Crohn's Disease Exclusion Diet is a Successful Strategy for Induction of Remission in Children and Adults Failing Biological Therapy. ( 28525622 )
2017
5
Effect of threatening life experiences and adverse family relations in ulcerative colitis: analysis using structural equation modeling and comparison with Crohn's disease. ( 28059861 )
2017
6
Efficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn's Disease Patients Stratified by Age. ( 28070861 )
2017
7
Clinical efficacy of adalimumab versus infliximab and the factors associated with recurrence or aggravation during treatment of anal fistulas in Crohn's disease. ( 28522947 )
2017
8
Diffusion-weighted MRI Enables to Accurately Grade Inflammatory Activity in Patients of Ileocolonic Crohn's Disease: Results from an Observational Study. ( 28079618 )
2017
9
Predictive Model for Differentiating Crohn's Disease and Intestinal Tuberculosis: The Story Is Incomplete Without Imaging. ( 28050042 )
2017
10
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. ( 28067912 )
2017
11
Adherence to an elemental diet for preventing postoperative recurrence of Crohn's disease. ( 28534264 )
2017
12
Treatment of Crohn's Disease Anastomotic Stricture with a Lumen-Apposing Metal Stent. ( 28529163 )
2017
13
Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn's disease: Systematic review and meta-analysis. ( 28512034 )
2017
14
Risk factors of surgical site infections in patients with Crohn's disease complicated with gastrointestinal fistula. ( 28091846 )
2017
15
The long-term outcome of anti-TNF alpha therapy in perianal Crohn's disease. ( 28066859 )
2017
16
Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn's Disease. ( 28045023 )
2017
17
Complications and Disease Recurrence After Primary Ileocecal Resection in Pediatric Crohn's Disease: A Multicenter Cohort Analysis. ( 28079626 )
2017
18
Increasing Incidence of Crohn's Disease with Familial Clustering in the Kingdom of Bahrain: A 25-Year Population-based Study. ( 28092308 )
2017
19
Impact of Crohn's Disease Duration on the Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. ( 28050039 )
2017
20
5-Aminosalicylates to maintain remission in Crohn's disease: Interpreting conflicting systematic review evidence. ( 28533918 )
2017
21
Ustekinumab: A Review in Moderate to Severe Crohn's Disease. ( 28528528 )
2017
22
Crohn's disease and smoldering multiple myeloma: a case report and literature review. ( 28522957 )
2017
23
Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. ( 28071062 )
2017
24
Recurrent Ileal Sub-Occlusion Related to Multiple Polyps and Misdiagnosed as Crohn's Disease. ( 28063970 )
2017
25
Association study between OCTN1 functional haplotypes and Crohn's disease in a Korean population. ( 28066136 )
2017
26
Levels of Faecal Calprotectin and Magnetic Resonance Enterocolonography Correlate with Severity of Small Bowel Crohn's Disease: A Retrospective Cohort Study. ( 28512287 )
2017
27
Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls. ( 28522944 )
2017
28
Fecal microbiota transplantation for refractory Crohn's disease. ( 28522956 )
2017
29
Adalimumab or infliximab: which is better for perianal fistula in Crohn's disease? ( 28522942 )
2017
30
Current status of endoscopic balloon dilation for Crohn's disease. ( 28522945 )
2017
31
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
32
Granulomas in mesenteric lymph nodes in Crohn's disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. ( 28087973 )
2017
33
Circulating Endothelial Progenitor Cells in Crohn's Disease: An EPiC in the Making? ( 28078527 )
2017
34
Can laparoscopic surgery prevent incisional hernia in patients with Crohn's disease: a comparison study of 750 patients undergoing open and laparoscopic bowel resection. ( 28523361 )
2017
35
Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis. ( 28523573 )
2017
36
Metastatic Crohn's Disease. ( 28527172 )
2017
37
Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease. ( 28528037 )
2017
38
Endoscopic and clinical responses to anti-tubercular therapy can differentiate intestinal tuberculosis from Crohn's disease. ( 27813111 )
2017
39
Crohn's Disease and Ulcerative Colitis Show Unique Cytokine Profiles. ( 28533995 )
2017
40
Diet to the Rescue: Cessation of Pharmacotherapy After Initiation of Exclusive Enteral Nutrition (EEN) Followed by Strict and Liberalized Specific Carbohydrate Diet (SCD) in Crohn's Disease. ( 28084605 )
2017
41
Responsiveness of Endoscopic Indices of Disease Activity for Crohn's Disease. ( 28071654 )
2017
42
Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab. ( 28377934 )
2017
43
The differential frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum of patients with Crohn's disease. ( 27215784 )
2016
44
Wernicke's encephalopathy after total parenteral nutrition in patients with Crohn's disease. ( 27175122 )
2016
45
Acute stroke revealing Takayasu's arteritis in a patient with Crohn's disease. ( 27075786 )
2016
46
Chronic Recurrent Multifocal Osteomyelitis in Crohn's Disease - Complete Resolution with Anti TNFI+ Therapy. ( 27050047 )
2016
47
A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders. ( 26891020 )
2016
48
The influence of anti-TNF therapy on CD31 and VEGF expression in colonic mucosa of Crohn's disease patients in relation to mucosal healing. ( 27270504 )
2016
49
Faecal microbiota transplantation for recurring Clostridium difficile infection in a patient with Crohn's disease and ileorectal anastomosis. ( 27664230 )
2016
50
Pirfenidone inhibits the proliferation of fibroblasts from patients with active Crohn's disease. ( 27181436 )
2016

Variations for Crohn's Disease

Copy number variations for Crohn's Disease from CNVD:

7 (show all 25)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19625 1 150839831 150840116 Deletion and duplication LCE3C Crohn''s disease
2 19631 1 150852910 150853198 Deletion and duplication LCE3B Crohn''s disease
3 71426 12 69818942 132349534 Copy number Crohn''s disease
4 112709 17 40930407 78774742 Copy number Crohn''s disease
5 139336 2 179004449 242951149 Copy number Crohn''s disease
6 194979 5 147200000 152100000 Low copy numbers IRGM Crohn''s disease
7 195288 5 149800000 152700000 Copy number Crohn''s disease
8 195354 5 150157836 180857866 Copy number Crohn''s disease
9 195374 5 150183562 180857866 Copy number Crohn''s disease
10 195384 5 150207878 150208422 Deletion IRGM Crohn''s disease
11 195385 5 150207878 150208422 Deletion and duplication IRGM Crohn''s disease
12 210788 6 31416574 170899992 Copy number Crohn''s disease
13 211338 6 32582950 170899992 Copy number Crohn''s disease
14 211384 6 32609209 170899992 Copy number Crohn''s disease
15 211736 6 336751 356443 Copy number IRF4 Crohn''s disease
16 230702 8 1 12700000 Copy number Crohn''s disease
17 241420 8 6200000 12700000 Copy number HBD-2 Crohn''s disease
18 241431 8 6200000 12700000 Duplication DEFB103 Crohn''s disease
19 241433 8 6200000 12700000 Duplication DEFB4 Crohn''s disease
20 241436 8 6200000 12700000 Duplication SPAG11 Crohn''s disease
21 241467 8 6200000 12700000 Low copy numbers Crohn''s disease
22 242030 8 6873390 6875823 Copy number Crohn''s disease
23 242532 8 7259842 7791647 Copy number DEFB4 Crohn''s disease
24 242534 8 7259842 7791647 Deletion and duplica tion DEFB4 Crohn''s disease
25 242535 8 7259842 7791647 Deletion and duplica tion HBD-2 Crohn''s disease

Expression for Crohn's Disease

LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.

Pathways for Crohn's Disease

GO Terms for Crohn's Disease

Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 ADAM17 CEACAM6 IL12RB2 SLC11A1 SLC22A4 SLC22A5
2 plasma membrane GO:0005886 9.44 ADAM17 CEACAM6 IL12RB2 IL18RAP IL23R IRGM
3 phagocytic cup GO:0001891 9.16 IRGM TNF

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 ADAM17 CEACAM6 FGFR1OP IL12RB2 NOD2
2 inflammatory response GO:0006954 9.88 IL18RAP IL23R IRGM SLC11A1 TNF
3 defense response to Gram-negative bacterium GO:0050829 9.63 IL23R IRGM SLC11A1
4 defense response GO:0006952 9.62 HP NOD2 SP140 TNF
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.59 NOD2 TNF
6 positive regulation of osteoclast differentiation GO:0045672 9.58 IL23R TNF
7 positive regulation of chemokine production GO:0032722 9.58 ADAM17 TNF
8 leukocyte tethering or rolling GO:0050901 9.57 ITGA4 TNF
9 positive regulation of interleukin-17 production GO:0032740 9.56 IL23R NOD2
10 defense response to bacterium GO:0042742 9.55 HP IRGM NOD2 SLC11A1 TNF
11 maintenance of gastrointestinal epithelium GO:0030277 9.54 MUC2 NOD2
12 positive regulation of T-helper 1 type immune response GO:0002827 9.52 IL23R SLC11A1
13 carnitine metabolic process GO:0009437 9.51 SLC22A4 SLC22A5
14 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.49 NOD2 SLC11A1
15 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.43 IRGM NOD2
16 carnitine transport GO:0015879 9.4 SLC22A4 SLC22A5
17 quaternary ammonium group transport GO:0015697 9.37 SLC22A4 SLC22A5
18 response to lipopolysaccharide GO:0032496 9.35 ADAM17 IL12RB2 IL18BP IL23R SLC11A1
19 carnitine transmembrane transport GO:1902603 9.26 SLC22A4 SLC22A5
20 positive regulation of interferon-gamma production GO:0032729 8.92 IL12RB2 IL23R SLC11A1 TNF

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 9.5 ADAM17 SLC22A4 SLC22A5
2 CARD domain binding GO:0050700 9.26 IRGM NOD2
3 carnitine transmembrane transporter activity GO:0015226 9.16 SLC22A4 SLC22A5
4 quaternary ammonium group transmembrane transporter activity GO:0015651 8.96 SLC22A4 SLC22A5
5 cation:cation antiporter activity GO:0015491 8.62 SLC22A4 SLC22A5

Sources for Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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