MCID: CRH001
MIFTS: 80

Crohn's Disease

Categories: Rare diseases, Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Crohn's Disease

MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 37 12 72 72 49 24 36 40 14
Pediatric Crohn's Disease 12 49 69
Crohn Disease 12 24 69
Enteritis 49 51 69
Crohn's Disease of Large Bowel 12 69
Granulomatous Colitis 12 49
Ileitis 49 69
Pediatric Onset Crohn's Disease 49
Crohn's Disease, Pediatric 49
Crohn's Disease of Colon 12
Enteritis, Granulomatous 24
Granulomatous Enteritis 49
Colitis, Granulomatous 24
Enteritis, Regional 24
Regional Enteritis 69
Crohn's Enteritis 24

Classifications:



Summaries for Crohn's Disease

MedlinePlus : 40 Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. Crohn's can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an abnormal reaction by the body's immune system. It also seems to run in some families. It most commonly starts between the ages of 13 and 30. The most common symptoms are pain in the abdomen and diarrhea. Other symptoms include Bleeding from the rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. Crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. People with Crohn's can also have joint pain and skin problems. Children with the disease may have growth problems. There is no cure for Crohn's. Treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. Some people have long periods of remission, when they are free of symptoms. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Crohn's Disease, also known as pediatric crohn's disease, is related to inflammatory bowel disease 1 and inflammatory bowel disease 25, autosomal recessive, and has symptoms including diarrhea, constipation and gastrointestinal gas. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Cytokine-cytokine receptor interaction. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference : 24 Crohn disease is a complex, long-lasting (chronic) disorder that primarily affects the digestive system. This condition involves an abnormal immune response that causes excess inflammation. It most often affects the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). However, inflammation can occur in any part of the digestive system, from the mouth to the anus. The inflamed tissues become thick and swollen, and the inner surfaces of the digestive system may develop open sores (ulcers).

NIH Rare Diseases : 49 Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the gastrointestinal (GI) tract. Common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. Other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. Complications of Crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to involve both genetic and environmental factors. It appears to run in some families. Treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. Last updated: 3/15/2016

Related Diseases for Crohn's Disease

Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 1 33.3 NOD2 SLC22A4 SLC22A5
2 inflammatory bowel disease 25, autosomal recessive 32.1 IL10RA IL10RB
3 ulcerative colitis 29.6 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRF5
4 colitis 29.5 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL23R
5 inflammatory bowel disease 27.8 ABCB1 ATG16L1 DUOX2 IL10RA IL10RB IL12RB2
6 thoraco abdominal enteric duplication 12.2
7 cryptogenic multifocal ulcerous stenosing enteritis 12.0
8 enteric pattern testicular yolk sac tumor 11.9
9 trichohepatoenteric syndrome 1 11.7
10 typhoid fever 11.5
11 crohn's colitis 11.5
12 diarrhea 4, malabsorptive, congenital 11.4
13 gastroenteritis 11.4
14 eosinophilic gastroenteritis 11.3
15 intestinal pseudo-obstruction 11.2
16 duodenitis 11.2
17 coccidiosis 11.2
18 hirschsprung disease 1 11.1
19 campylobacteriosis 11.1
20 amebiasis 11.1
21 coccidioidomycosis 11.1
22 visceral myopathy 11.1
23 aspiration pneumonia 11.1
24 endocarditis 11.1
25 thiopurines, poor metabolism of, 1 11.1
26 hermansky-pudlak syndrome 4 11.0
27 hermansky-pudlak syndrome 5 11.0
28 inflammatory bowel disease 10 10.9
29 inflammatory bowel disease 13 10.9
30 inflammatory bowel disease 14 10.9
31 inflammatory bowel disease 17 10.9
32 inflammatory bowel disease 19 10.9
33 inflammatory bowel disease 28, autosomal recessive 10.9
34 bile acid malabsorption, primary 10.8
35 autoimmune disease 6 10.8
36 short bowel syndrome 10.8
37 intestinal disease 10.4 ATG16L1 IL23R IRGM NOD2
38 ovarian mucinous adenocarcinoma 10.4 ABCB1 MUC2
39 carnitine deficiency, systemic primary 10.4 SLC22A4 SLC22A5
40 inflammatory bowel disease 5 10.3 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
41 sarcoidosis 1 10.3 IL12RB2 NOD2 SLC11A1
42 leprosy 3 10.3 IL12RB2 LACC1 NOD2 SLC11A1
43 primary biliary cholangitis 10.2 IL12RB2 IRF5
44 ovarian cystadenocarcinoma 10.1 ABCB1 UBE4A
45 jejunoileitis 10.1
46 gastroduodenal crohn's disease 10.1
47 hidradenitis suppurativa 9.8
48 hidradenitis 9.8
49 pustulosis of palm and sole 9.8
50 psoriasis 9.8

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Inflammatory Bowel Disease 1
Intestinal Obstruction Protein-Energy Malnutrition
Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease

Symptoms & Phenotypes for Crohn's Disease

UMLS symptoms related to Crohn's Disease:


diarrhea, constipation, gastrointestinal gas, nausea and vomiting, icterus, heartburn, dyspepsia, abdominal pain

MGI Mouse Phenotypes related to Crohn's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 ABCB1 IL23R ATG16L1 MUC2 IL10RA NOD2
2 hematopoietic system MP:0005397 9.93 IL12RB2 ABCB1 IL23R ATG16L1 IRF5 ITGA4
3 endocrine/exocrine gland MP:0005379 9.86 IL12RB2 IL18BP ABCB1 IL23R ATG16L1 DUOX2
4 homeostasis/metabolism MP:0005376 9.77 SLC22A4 SLC22A5 IL12RB2 ABCB1 IL23R ATG16L1
5 immune system MP:0005387 9.44 ABCB1 IL23R ATG16L1 IRF5 ITGA4 HP

Drugs & Therapeutics for Crohn's Disease

Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 414)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 657311 5754
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
5
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
6
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
7
Rifabutin Approved, Investigational Phase 4,Phase 3 72559-06-9 6323490
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
10
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
11
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
12
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 5281004 63006
13
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
14
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
15
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
16
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
17
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
18
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
19
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
20
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
21
Etidronic acid Approved Phase 4 2809-21-4, 7414-83-7 3305
22
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
23 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 943609-66-3
24
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
25
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
26
Everolimus Approved Phase 4 159351-69-6 6442177
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
28
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
29
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
30
Dextromethorphan Approved Phase 4,Phase 1 125-71-3 5362449 5360696
31
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 1 93-14-1 3516
32
Losartan Approved Phase 4 114798-26-4 3961
33
Thioguanine Approved Phase 4 154-42-7 2723601
34
Vancomycin Approved Phase 4,Phase 2 1404-90-6 14969 441141
35
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
36
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
37
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
38
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 10883523 5280795 6221
39
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 50-14-6 5280793
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
41
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1406-16-2
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
44
Menadione Approved, Nutraceutical Phase 4,Phase 1 58-27-5 4055
45
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 1 84-80-0 5284607 4812
46
Caffeine Approved, Nutraceutical Phase 4,Phase 1 58-08-2 2519
47 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1104)

# Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
5 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
6 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
7 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
8 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
9 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
12 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
13 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
14 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
15 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
16 Precision Dosing of Infliximab Versus Conventional Dosing of Infliximab Unknown status NCT02453776 Phase 4 PRECISION dosing Infliximab
17 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
18 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
19 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
20 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
21 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
22 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
23 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
24 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
25 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
26 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
27 Endoscopic Severity Score of Small Bowel Crohn's Disease With Wireless Capsule Endoscopy Completed NCT00492791 Phase 4
28 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
29 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
30 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
31 The Crohn's Therapy, Resource, Evaluation, and Assessment Tool Registry Completed NCT00553176 Phase 4
32 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
33 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
34 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
35 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
36 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
37 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
38 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
39 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
40 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
41 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
42 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
43 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
44 An Observational Study of Lymphoma in Patients With Rheumatoid Arthritis or Crohn's Disease. Completed NCT00440817 Phase 4
45 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
46 Remicade Infusion Management Program Completed NCT00723905 Phase 4
47 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
48 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
49 A Long-term Safety Study of Infliximab (Remicade) Completed NCT00261976 Phase 4 Infliximab (Remicade)
50 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.

Genetic Tests for Crohn's Disease

Anatomical Context for Crohn's Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Crohn's Disease:

18
Intestine

MalaCards organs/tissues related to Crohn's Disease:

38
Colon, Bone, T Cells, Testes, Small Intestine, Kidney, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Crohn's Disease

Articles related to Crohn's Disease:

(show top 50) (show all 2862)
# Title Authors Year
1
Budd-Chiari syndrome: a rare and life-threatening complication of Crohn's disease. ( 29348288 )
2018
2
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
3
A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease. ( 29452228 )
2018
4
Crohn's Disease Candidate Gene Alleles Predict Time to Progression from Inflammatory B1 to Stricturing B2, or Penetrating B3 Phenotype. ( 29446656 )
2018
5
Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by Magnetic Resonance Enterography. ( 29361096 )
2018
6
Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis. ( 29441064 )
2018
7
A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population. ( 29441677 )
2018
8
Crohn's Disease associated Strictures. ( 29427364 )
2018
9
A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease. ( 28961694 )
2018
10
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? Authors' reply. ( 29446137 )
2018
11
Histologic features in pediatric ileitis: Is it possible to tip the balance towards Crohn's disease? ( 29397324 )
2018
12
Crohn's Disease Behavior and Location is Altered when Associated with Primary Sclerosing Cholangitis. ( 29333790 )
2018
13
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
14
Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence. ( 29434453 )
2018
15
Clinical utility of ustekinumab in Crohn's disease. ( 29445293 )
2018
16
T-cell immune response against cytomegalovirus in peripheral blood and colonic mucosa from ulcerative colitis and Crohn's disease patients. ( 29422814 )
2018
17
Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohn's Disease. ( 29430467 )
2018
18
Does a histologically inflamed resection margin increase postoperative complications in patients with Crohn's disease? ( 29431516 )
2018
19
Enteral Nutrition for Pediatric Crohn's Disease: An Underutilized Therapy. ( 29446858 )
2018
20
The assessment of online heath videos for surgery in Crohn's Disease. ( 29427466 )
2018
21
Developing a core outcome set for fistulising perianal Crohn's disease. ( 29437911 )
2018
22
Prognostic value of preoperative neutrophil-to-lymphocyte ratio in Crohn's disease. ( 29435759 )
2018
23
Perianal Crohn's disease - association with significant inflammatory activity in proximal small bowel segments. ( 29447487 )
2018
24
Systematic Review With Meta-Analysis: Anti-TNF Therapy in Refractory Pouchitis and Crohn's Disease-Like Complications of the Pouch After Ileal Pouch-Anal Anastomosis Following Colectomy for Ulcerative Colitis. ( 29361101 )
2018
25
Filgotinib for the treatment of Crohn's disease. ( 29448862 )
2018
26
IgG4-Related Disease Mimicking Crohn's Disease: A Case Report and Review of Literature. ( 29417330 )
2018
27
Crohn's Disease in Niemann-Pick Disease Type C1: Caught in the Cross-Fire of Host-Microbial Interactions. ( 29411209 )
2018
28
Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. ( 29434451 )
2018
29
Letter: mucosal response in discriminating intestinal tuberculosis from Crohn's disease-when to look for it? ( 29446132 )
2018
30
Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography. ( 28852526 )
2017
31
Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide. ( 29142522 )
2017
32
Paradoxical SAPHO syndrome observed during anti-TNFI+ therapy for Crohn's disease. ( 28579754 )
2017
33
Crohn's disease and smoldering multiple myeloma: a case report and literature review. ( 28522957 )
2017
34
5-Aminosalicylates to maintain remission in Crohn's disease: Interpreting conflicting systematic review evidence. ( 28533918 )
2017
35
Diet to the Rescue: Cessation of Pharmacotherapy After Initiation of Exclusive Enteral Nutrition (EEN) Followed by Strict and Liberalized Specific Carbohydrate Diet (SCD) in Crohn's Disease. ( 28084605 )
2017
36
MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. ( 28190086 )
2017
37
Prolonged azathioprine treatment reduces the need for surgery in early Crohn's disease. ( 28940780 )
2017
38
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
39
Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity inA Crohn's Disease. ( 28400196 )
2017
40
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis. ( 28165466 )
2017
41
Safety and Efficacy of Exclusive Enteral Nutrition for Percutaneously Undrainable Abdominal Abscesses in Crohn's Disease. ( 28947899 )
2017
42
Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. ( 28071062 )
2017
43
Primary intestinal choriocarcinoma in a patient with long-standing Crohn's disease. ( 29205146 )
2017
44
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial. ( 28838644 )
2017
45
Amblyopia due to intermediate uveitis as the presenting symptom of Crohn's disease in a 6-year-old boy. ( 29102673 )
2017
46
Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls. ( 28522944 )
2017
47
An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease. ( 28472811 )
2017
48
Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. ( 28792733 )
2017
49
Nonsteroidal anti-inflammatory drug-induced protein-losing enteropathy: a great masquerade of Crohn's disease. ( 28554654 )
2017
50
Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis. ( 28523573 )
2017

Variations for Crohn's Disease

Copy number variations for Crohn's Disease from CNVD:

7 (show all 25)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19625 1 150839831 150840116 Deletion and duplication LCE3C Crohn''s disease
2 19631 1 150852910 150853198 Deletion and duplication LCE3B Crohn''s disease
3 71426 12 69818942 132349534 Copy number Crohn''s disease
4 112709 17 40930407 78774742 Copy number Crohn''s disease
5 139336 2 179004449 242951149 Copy number Crohn''s disease
6 194979 5 147200000 152100000 Low copy numbers IRGM Crohn''s disease
7 195288 5 149800000 152700000 Copy number Crohn''s disease
8 195354 5 150157836 180857866 Copy number Crohn''s disease
9 195374 5 150183562 180857866 Copy number Crohn''s disease
10 195384 5 150207878 150208422 Deletion IRGM Crohn''s disease
11 195385 5 150207878 150208422 Deletion and duplication IRGM Crohn''s disease
12 210788 6 31416574 170899992 Copy number Crohn''s disease
13 211338 6 32582950 170899992 Copy number Crohn''s disease
14 211384 6 32609209 170899992 Copy number Crohn''s disease
15 211736 6 336751 356443 Copy number IRF4 Crohn''s disease
16 230702 8 1 12700000 Copy number Crohn''s disease
17 241420 8 6200000 12700000 Copy number HBD-2 Crohn''s disease
18 241431 8 6200000 12700000 Duplication DEFB103 Crohn''s disease
19 241433 8 6200000 12700000 Duplication DEFB4 Crohn''s disease
20 241436 8 6200000 12700000 Duplication SPAG11 Crohn''s disease
21 241467 8 6200000 12700000 Low copy numbers Crohn''s disease
22 242030 8 6873390 6875823 Copy number Crohn''s disease
23 242532 8 7259842 7791647 Copy number DEFB4 Crohn''s disease
24 242534 8 7259842 7791647 Deletion and duplica tion DEFB4 Crohn''s disease
25 242535 8 7259842 7791647 Deletion and duplica tion HBD-2 Crohn''s disease

Expression for Crohn's Disease

LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.

Pathways for Crohn's Disease

Pathways related to Crohn's Disease according to KEGG:

36
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Cytokine-cytokine receptor interaction hsa04060
3 Jak-STAT signaling pathway hsa04630
4 Inflammatory bowel disease (IBD) hsa05321
5 Autophagy - animal hsa04140

GO Terms for Crohn's Disease

Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.47 ABCB1 CEACAM6 DUOX2 IL10RA IL10RB IL12RB2
2 apical plasma membrane GO:0016324 9.26 ABCB1 DUOX2 SLC22A4 SLC22A5

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.81 HP IRGM NOD2 SLC11A1
2 defense response to Gram-negative bacterium GO:0050829 9.7 IL23R IRGM SLC11A1
3 positive regulation of interleukin-12 production GO:0032735 9.59 IL23R IRF5
4 drug transmembrane transport GO:0006855 9.58 ABCB1 SLC22A5
5 response to interferon-gamma GO:0034341 9.58 IL23R SLC11A1
6 organic anion transport GO:0015711 9.57 SLC22A4 SLC22A5
7 positive regulation of interleukin-17 production GO:0032740 9.56 IL23R NOD2
8 response to muramyl dipeptide GO:0032495 9.55 IRF5 NOD2
9 maintenance of gastrointestinal epithelium GO:0030277 9.54 MUC2 NOD2
10 positive regulation of interferon-gamma production GO:0032729 9.5 IL12RB2 IL23R SLC11A1
11 positive regulation of T-helper 1 type immune response GO:0002827 9.49 IL23R SLC11A1
12 carnitine metabolic process GO:0009437 9.48 SLC22A4 SLC22A5
13 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.46 IRGM NOD2
14 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.43 NOD2 SLC11A1
15 carnitine transport GO:0015879 9.4 SLC22A4 SLC22A5
16 quaternary ammonium group transport GO:0015697 9.37 SLC22A4 SLC22A5
17 response to lipopolysaccharide GO:0032496 9.35 IL10RA IL12RB2 IL18BP IL23R SLC11A1
18 protein lipidation involved in autophagosome assembly GO:0061739 9.26 ATG16L1 IRGM
19 carnitine transmembrane transport GO:1902603 9.16 SLC22A4 SLC22A5
20 cytokine-mediated signaling pathway GO:0019221 9.02 DUOX2 IL10RA IL10RB IL12RB2 IRF5

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.54 ABCB1 SLC22A4 SLC22A5
2 organic anion transmembrane transporter activity GO:0008514 9.4 SLC22A4 SLC22A5
3 CARD domain binding GO:0050700 9.32 IRGM NOD2
4 interleukin-10 receptor activity GO:0004920 9.26 IL10RA IL10RB
5 quaternary ammonium group transmembrane transporter activity GO:0015651 9.16 SLC22A4 SLC22A5
6 carnitine transmembrane transporter activity GO:0015226 8.96 SLC22A4 SLC22A5
7 cation:cation antiporter activity GO:0015491 8.62 SLC22A4 SLC22A5

Sources for Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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