MCID: CRH001
MIFTS: 73

Crohn's Disease

Categories: Rare diseases, Gastrointestinal diseases, Infectious diseases, Genetic diseases

Aliases & Classifications for Crohn's Disease

MalaCards integrated aliases for Crohn's Disease:

Name: Crohn's Disease 38 12 72 50 25 41 14
Crohn Disease 12 24 25 69
Pediatric Crohn's Disease 12 50 69
Enteritis 50 52 69
Ileitis 50 25 69
Crohn's Disease of Large Bowel 12 69
Granulomatous Colitis 12 50
Pediatric Onset Crohn's Disease 50
Crohn's Disease, Pediatric 50
Crohn's Disease of Colon 12
Enteritis, Granulomatous 25
Granulomatous Enteritis 50
Colitis, Granulomatous 25
Enteritis, Regional 25
Regional Enteritis 69
Crohn's Enteritis 25
Ileocolitis 25
Iieocolitis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8778
ICD9CM 35 555.1
MeSH 42 D003424
UMLS 69 C0156147

Summaries for Crohn's Disease

MedlinePlus : 41 crohn's disease causes inflammation of the digestive system. it is one of a group of diseases called inflammatory bowel disease. crohn's can affect any area from the mouth to the anus. it often affects the lower part of the small intestine called the ileum. the cause of crohn's disease is unknown. it may be due to an abnormal reaction by the body's immune system. it also seems to run in some families. it most commonly starts between the ages of 13 and 30. the most common symptoms are pain in the abdomen and diarrhea. other symptoms include bleeding from the rectum weight loss fever your doctor will diagnose crohn's disease with a physical exam, lab tests, imaging tests, and a colonoscopy. crohn's can cause complications, such as intestinal blockages, ulcers in the intestine, and problems getting enough nutrients. people with crohn's can also have joint pain and skin problems. children with the disease may have growth problems. there is no cure for crohn's. treatment can help control symptoms, and may include medicines, nutrition supplements, and/or surgery. some people have long periods of remission, when they are free of symptoms. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Crohn's Disease, also known as crohn disease, is related to crohn disease-associated growth failure and thoraco abdominal enteric duplication, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Crohn's Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Innate Immune System. The drugs Adalimumab and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 An intestinal disease that involves inflammation located in intestine.

Genetics Home Reference : 25 Crohn disease is a complex, chronic disorder that primarily affects the digestive system. This condition typically involves abnormal inflammation of the intestinal walls, particularly in the lower part of the small intestine (the ileum) and portions of the large intestine (the colon). Inflammation can occur in any part of the digestive system, however. The inflamed tissues become thick and swollen, and the inner surface of the intestine may develop open sores (ulcers).

NIH Rare Diseases : 50 crohn's disease is a type of inflammatory bowel disease (ibd), the general name for conditions that cause inflammation in the gastrointestinal (gi) tract. common signs and symptoms include abdominal pain and cramping, diarrhea, and weight loss. other general symptoms include feeling tired, nausea and loss of appetite, fever, and anemia. complications of crohn's disease may include intestinal blockage, fistulas, anal fissures, ulcers, malnutrition, and inflammation in other areas of the body. crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. the exact cause is unknown, but is thought to involve both genetic and environmental factors. it appears to run in some families. treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery. last updated: 3/15/2016

Wikipedia : 72 Crohn\'s disease is a type of inflammatory bowel disease (IBD) that may affect any part of the... more...

Related Diseases for Crohn's Disease

Diseases related to Crohn's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 crohn disease-associated growth failure 12.2
2 thoraco abdominal enteric duplication 12.1
3 ileocolitis 12.0
4 cryptogenic multifocal ulcerous stenosing enteritis 11.9
5 enteric pattern testicular yolk sac tumor 11.8
6 trichohepatoenteric syndrome 1 11.5
7 typhoid fever 11.4
8 gastroenteritis 11.3
9 eosinophilic gastroenteritis 11.3
10 crohn's colitis 11.2
11 intestinal pseudo-obstruction 11.1
12 aspiration pneumonia 11.0
13 visceral myopathy 11.0
14 endocarditis 11.0
15 diarrhea 4, malabsorptive, congenital 11.0
16 hermansky-pudlak syndrome 4 10.9
17 hermansky-pudlak syndrome 5 10.9
18 inflammatory bowel disease 25, early onset, autosomal recessive 10.8
19 inflammatory bowel disease 13 10.8
20 inflammatory bowel disease 14 10.8
21 inflammatory bowel disease 17, protection against 10.8
22 inflammatory bowel disease 28, early onset, autosomal recessive 10.8
23 inflammatory bowel disease 10 10.8
24 inflammatory bowel disease 19 10.8
25 thiopurines, poor metabolism of, 1 10.7
26 short bowel syndrome 10.7
27 autoimmune disease 6 10.7
28 bile acid malabsorption, primary 10.7
29 saethre-chotzen syndrome 10.6 NOD2 SLC22A4 SLC22A5
30 microcephaly, short stature, and limb abnormalities 10.6 IL10RA IL10RB
31 endometrial clear cell adenocarcinoma 10.6 ATG16L1 IL23R IRGM NOD2
32 appendix adenocarcinoma 10.5 ABCB1 UBE4A
33 allergic rhinitis 10.5 ATG16L1 IL23R NOD2 SLC22A4 SLC22A5
34 primary fanconi syndrome 10.4 IL12RB2 IRF5
35 inflammatory bowel disease 3 10.4 IL12RB2 NOD2 SLC11A1
36 intussusception 10.4
37 aspartylglucosaminuria 10.3 IL12RB2 LACC1 NOD2 SLC11A1
38 mitochondrial complex iii deficiency, nuclear type 4 10.3 SLC22A4 SLC22A5
39 jejunoileitis 10.0
40 gastroduodenal crohn's disease 10.0
41 colitis 9.9
42 ulcerative colitis 9.9
43 asphyxiating thoracic dystrophy 9.9 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRGM
44 psoriasis 9.8
45 hidradenitis suppurativa 9.8
46 hidradenitis 9.8
47 adenocarcinoma 9.7
48 tuberculosis 9.7
49 vocal cord scarring 9.7 ABCB1 ATG16L1 IL10RA IL10RB IL23R IRF5
50 vasculitis 9.7

Comorbidity relations with Crohn's Disease via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Esophagitis
Intestinal Obstruction Iron Deficiency Anemia
Osteoporosis Paralytic Ileus
Protein-Energy Malnutrition Ulcerative Colitis

Graphical network of the top 20 diseases related to Crohn's Disease:



Diseases related to Crohn's Disease

Symptoms & Phenotypes for Crohn's Disease

UMLS symptoms related to Crohn's Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Crohn's Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 MUC2 NOD2 SLC11A1 SLC22A4 ABCB1 ATG16L1
2 hematopoietic system MP:0005397 9.93 ABCB1 ATG16L1 HP IL10RA IL10RB IL12RB2
3 endocrine/exocrine gland MP:0005379 9.86 ABCB1 ATG16L1 DUOX2 IL10RB IL12RB2 IL18BP
4 homeostasis/metabolism MP:0005376 9.77 ABCB1 ATG16L1 DUOX2 HP IL10RA IL10RB
5 immune system MP:0005387 9.44 ABCB1 ATG16L1 HP IL10RA IL10RB IL12RB2

Drugs & Therapeutics for Crohn's Disease

Drugs for Crohn's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 401)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
2
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
3
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
4
Clofazimine Approved, Investigational Phase 4,Phase 3 2030-63-9 2794
5
Rifabutin Approved Phase 4,Phase 3 72559-06-9 6323490
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
8
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
9
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
10
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
11
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
12
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
13
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
14
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
15
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
16
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
17
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
18
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
19
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1 443-48-1 4173
20
Etidronic acid Approved Phase 4 7414-83-7, 2809-21-4 3305
21
Natalizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 189261-10-7
22 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Early Phase 1 943609-66-3
23
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
24
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
25
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
26
Everolimus Approved Phase 4 159351-69-6 6442177
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
28
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
29
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
30
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
31
Losartan Approved Phase 4 114798-26-4 3961
32
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
33
Vancomycin Approved Phase 4,Phase 2 1404-90-6 441141 14969
34
Thioguanine Approved Phase 4 154-42-7 2723601
35
Sulfamethazine Approved, Vet_approved Phase 4 57-68-1 5327
36
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
37
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 50-14-6 5280793
39 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 1406-16-2
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
43
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
44
Phytonadione Approved, Nutraceutical Phase 4 84-80-0 4812 5284607
45
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
46
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
47 Antibodies Phase 4,Phase 2,Phase 3,Phase 1
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1069)

id Name Status NCT ID Phase Drugs
1 A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Unknown status NCT01632462 Phase 4 VSL#3
2 Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy Unknown status NCT00851565 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Treatment of Crohn's Disease With an Antibiotic Regimen Directed Against Mycobacterium Avium Paratuberculosis Unknown status NCT00513552 Phase 4 Rifabutin, Clarithromycin, and Clofazimine
5 Comparison of a Nutritional Anti-Inflammatory Treatment to Steroids for Pediatric Crohn's Disease - the Molecular Basis Unknown status NCT00265772 Phase 4 MODULEN IBD (R) (specific Enteral Nutrition);prednisolon
6 Evaluation of PET CT in the Management of Patients With Crohn's Disease. Unknown status NCT00731809 Phase 4
7 Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult Unknown status NCT02056418 Phase 4 corticosteroid
8 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
9 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Unknown status NCT02010762 Phase 4 Vitamin D;Placebo
10 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
11 Discontinuation of Infliximab Therapy in Patients With Crohn's Disease During Sustained Complete Remission Unknown status NCT01817426 Phase 4 Infliximab
12 Optimizing Cimzia in Crohn's Patients Unknown status NCT01024647 Phase 4
13 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
14 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
15 Confocal Endomicroscopy During Endoscopy Unknown status NCT00988273 Phase 4
16 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
17 Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease Completed NCT00588653 Phase 4
18 Trial of a Treatment Algorithm for the Management of Crohn's Disease Completed NCT01030809 Phase 4
19 A Study Comparing the Acceptability of Pentasa® Sachets Versus Pentasa® Tablets in Children With Crohn´s Disease Completed NCT00225810 Phase 4 Crohn's Disease
20 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
21 SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD). Completed NCT02199626 Phase 4
22 VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease Completed NCT00114465 Phase 4 VSL#3
23 Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease Completed NCT02148718 Phase 4
24 Endoscopic Severity Score of Small Bowel Crohn's Disease With Wireless Capsule Endoscopy Completed NCT00492791 Phase 4
25 Evaluation of the Applicability of the CDEIS to Data Obtained by the Colonic Capsule Endoscopy in Crohn Disease Completed NCT01183845 Phase 4
26 Top Down Versus Step Up Strategies in Crohn's Disease Completed NCT00554710 Phase 4 infliximab+azathioprine;methylprednisolone or budesonide
27 The Efficacy of Open Label Infliximab for the Induction and Maintenance of Mucosal Healing in Small Bowel Crohn's Disease Assessed Through Wireless Camera Endoscopy Completed NCT01181765 Phase 4
28 Infliximab for the Prevention of Recurrent Crohn's Disease After Surgery Completed NCT00688636 Phase 4 infliximab;placebo
29 Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease Completed NCT01596894 Phase 4 Azithromycin + Metronidazole;Metronidazole
30 The Crohn's Therapy, Resource, Evaluation, and Assessment Tool Registry Completed NCT00553176 Phase 4
31 Vitamin D Supplementation in Adult Crohn's Disease Completed NCT01369667 Phase 4
32 Early Immunosuppressants in Crohn's Disease Completed NCT00546546 Phase 4 early immunosuppressants (azathioprine, methotrexate)
33 Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease Completed NCT01442025 Phase 4 Infliximab;Infliximab;Infliximab
34 Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease Completed NCT01215890 Phase 4 risedronate;placebo
35 Adalimumab-psoriasis and Small Bowel Lesions Completed NCT01556672 Phase 4 Adalimumab
36 Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Completed NCT00280956 Phase 4 natalizumab
37 The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients Completed NCT01235325 Phase 4
38 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
39 Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease Completed NCT02349594 Phase 4 Omegaven 10%;Intralipid 20%
40 Vitamin D in Pediatric Crohn's Disease Completed NCT01187459 Phase 4
41 An Observational Study of Lymphoma in Patients With Rheumatoid Arthritis or Crohn's Disease. Completed NCT00440817 Phase 4
42 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
43 Vitd and Barrier Function in IBD Completed NCT01792388 Phase 4
44 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
45 Remicade Infusion Management Program Completed NCT00723905 Phase 4
46 The NOR-SWITCH Study Completed NCT02148640 Phase 4 Innovator infliximab;Biosimilar infliximab
47 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
48 A Long-term Safety Study of Infliximab (Remicade) Completed NCT00261976 Phase 4 Infliximab (Remicade)
49 Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas Completed NCT00517296 Phase 4 adalimumab
50 Centocor Microarray Study of Patients Completed NCT00462072 Phase 4 Infliximab

Search NIH Clinical Center for Crohn's Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Crohn's Disease cell therapies at LifeMap Discovery.

Genetic Tests for Crohn's Disease

Genetic tests related to Crohn's Disease:

id Genetic test Affiliating Genes
1 Crohn Disease 24 NOD2

Anatomical Context for Crohn's Disease

MalaCards organs/tissues related to Crohn's Disease:

39
Colon, Bone, T Cells, Testes, Skin, Small Intestine, Kidney
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crohn's Disease:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Crohn's Disease

Articles related to Crohn's Disease:

(show top 50) (show all 2804)
id Title Authors Year
1
Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis. ( 28523573 )
2017
2
Defective ATG16L1-mediated removal of IRE1I+ drives Crohn's disease-like ileitis. ( 28082357 )
2017
3
Nodular Vasculitis in a Patient With Crohn's Disease on Vedolizumab. ( 28953016 )
2017
4
Antineutrophil cytoplasmic antibodies associated vasculitis in patient with Crohn's disease treated with adalimumab. ( 28946973 )
2017
5
The Ileitis of Ulcerative Colitis. Why Is It Not Crohn's Disease? ( 28079623 )
2017
6
Laparoscopic resection for primary and recurrent Crohn's disease: AA case series of over 100 consecutive cases. ( 28951290 )
2017
7
Can we rely on inflammatory biomarkers for the diagnosis and monitoring Crohn's disease activity? ( 28950707 )
2017
8
Meta-Analytic Bayesian Model For Differentiating Intestinal Tuberculosis from Crohn's Disease. ( 28045023 )
2017
9
Miliary tuberculosis during adalimumab therapy in Crohn's disease. ( 28743405 )
2017
10
Responsiveness of Endoscopic Indices of Disease Activity for Crohn's Disease. ( 28071654 )
2017
11
Plasmablastic Lymphoma in a Patient With Crohn's Disease After Extensive Immunosuppressive Therapy. ( 28782668 )
2017
12
Increasing Incidence of Crohn's Disease with Familial Clustering in the Kingdom of Bahrain: A 25-Year Population-based Study. ( 28092308 )
2017
13
Perianal eccrine hidradenocarcinoma in the context of a fistulising Crohn's disease. ( 28827020 )
2017
14
Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohn's disease with fecal calprotectin. ( 28071062 )
2017
15
Effect of threatening life experiences and adverse family relations in ulcerative colitis: analysis using structural equation modeling and comparison with Crohn's disease. ( 28059861 )
2017
16
The long-term outcome of anti-TNF alpha therapy in perianal Crohn's disease. ( 28066859 )
2017
17
Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn's disease: Systematic review and meta-analysis. ( 28512034 )
2017
18
Can Inspection of the Mouth Help Clinicians Diagnose Crohn's Disease? A Review. ( 28530005 )
2017
19
Adalimumab or infliximab: which is better for perianal fistula in Crohn's disease? ( 28522942 )
2017
20
Paradoxical SAPHO syndrome observed during anti-TNFI+ therapy for Crohn's disease. ( 28579754 )
2017
21
Adherence to an elemental diet for preventing postoperative recurrence of Crohn's disease. ( 28534264 )
2017
22
Foreign body ileitis: a histopathological mimic of Crohn's disease? ( 28689632 )
2017
23
Exclusive and partial enteral nutrition for Crohn's disease - Authors' reply. ( 28952446 )
2017
24
Treatment of Crohn's Disease Anastomotic Stricture with a Lumen-Apposing Metal Stent. ( 28529163 )
2017
25
Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? ( 28560286 )
2017
26
Current status of endoscopic balloon dilation for Crohn's disease. ( 28522945 )
2017
27
Diet to the Rescue: Cessation of Pharmacotherapy After Initiation of Exclusive Enteral Nutrition (EEN) Followed by Strict and Liberalized Specific Carbohydrate Diet (SCD) in Crohn's Disease. ( 28084605 )
2017
28
Tissue Drug Concentrations of Anti-tumor Necrosis Factor Agents Are Associated with the Long-term Outcome of Patients with Crohn's Disease. ( 28945638 )
2017
29
Pyoderma gangrenosum associated with Crohn's disease in a Malawian teenage boy: case report and review of literature. ( 28767000 )
2017
30
Fecal microbiota transplantation for refractory Crohn's disease. ( 28522956 )
2017
31
Erythema elevatum diutinum in Crohn's disease-associated Spondyloarthritis - a rare vasculitis, an unusual association. ( 28917218 )
2017
32
Nonsteroidal anti-inflammatory drug-induced protein-losing enteropathy: a great masquerade of Crohn's disease. ( 28554654 )
2017
33
Impact of Crohn's Disease Duration on the Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis. ( 28050039 )
2017
34
Aspecific ileitis: Crohn's disease or not Crohn's disease? A prospective study. ( 28161731 )
2017
35
Dietary Therapy with the Crohn's Disease Exclusion Diet is a Successful Strategy for Induction of Remission in Children and Adults Failing Biological Therapy. ( 28525622 )
2017
36
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
37
Endoscopic and clinical responses to anti-tubercular therapy can differentiate intestinal tuberculosis from Crohn's disease. ( 27813111 )
2017
38
Anoperineal lesions in Crohn's disease: French recommendations for clinical practice. ( 28929282 )
2017
39
Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis. ( 28424866 )
2017
40
Exclusive and partial enteral nutrition for Crohn's disease. ( 28952445 )
2017
41
Successful treatment of chronic hepatitis C with ground ledipasvir/sofosbuvir in a patient with Crohn's disease and short bowel syndrome. ( 28783205 )
2017
42
Crohn's disease and acquired von Willebrand syndrome: a rare dangerous affair? ( 28103720 )
2017
43
Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. ( 28792733 )
2017
44
Metastatic Crohn's Disease. ( 28527172 )
2017
45
IBD LIVE Series-Case 8: Treatment Options for Refractory Esophageal Crohn's Disease and Hidradenitis Suppurativa. ( 28906288 )
2017
46
Comparison of Transperianal Ultrasound With Colonoscopy and Magnetic Resonance Imaging in Perianal Crohn's Disease. ( 28953535 )
2017
47
Efficacy and Safety of Vedolizumab in Ulcerative Colitis and Crohn's Disease Patients Stratified by Age. ( 28070861 )
2017
48
Chronic cheilitis: Faecal calprotectin test a way to diagnose oral Crohn's disease. ( 28731524 )
2017
49
Validation of Risk Factors for Fecal Incontinence in Patients With Crohn's Disease. ( 28682970 )
2017
50
Prolonged azathioprine treatment reduces the need for surgery in early Crohn's disease. ( 28940780 )
2017

Variations for Crohn's Disease

Copy number variations for Crohn's Disease from CNVD:

7 (show all 25)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 19625 1 150839831 150840116 Deletion and duplication LCE3C Crohn''s disease
2 19631 1 150852910 150853198 Deletion and duplication LCE3B Crohn''s disease
3 71426 12 69818942 132349534 Copy number Crohn''s disease
4 112709 17 40930407 78774742 Copy number Crohn''s disease
5 139336 2 179004449 242951149 Copy number Crohn''s disease
6 194979 5 147200000 152100000 Low copy numbers IRGM Crohn''s disease
7 195288 5 149800000 152700000 Copy number Crohn''s disease
8 195354 5 150157836 180857866 Copy number Crohn''s disease
9 195374 5 150183562 180857866 Copy number Crohn''s disease
10 195384 5 150207878 150208422 Deletion IRGM Crohn''s disease
11 195385 5 150207878 150208422 Deletion and duplication IRGM Crohn''s disease
12 210788 6 31416574 170899992 Copy number Crohn''s disease
13 211338 6 32582950 170899992 Copy number Crohn''s disease
14 211384 6 32609209 170899992 Copy number Crohn''s disease
15 211736 6 336751 356443 Copy number IRF4 Crohn''s disease
16 230702 8 1 12700000 Copy number Crohn''s disease
17 241420 8 6200000 12700000 Copy number HBD-2 Crohn''s disease
18 241431 8 6200000 12700000 Duplication DEFB103 Crohn''s disease
19 241433 8 6200000 12700000 Duplication DEFB4 Crohn''s disease
20 241436 8 6200000 12700000 Duplication SPAG11 Crohn''s disease
21 241467 8 6200000 12700000 Low copy numbers Crohn''s disease
22 242030 8 6873390 6875823 Copy number Crohn''s disease
23 242532 8 7259842 7791647 Copy number DEFB4 Crohn''s disease
24 242534 8 7259842 7791647 Deletion and duplica tion DEFB4 Crohn''s disease
25 242535 8 7259842 7791647 Deletion and duplica tion HBD-2 Crohn''s disease

Expression for Crohn's Disease

LifeMap Discovery
Genes differentially expressed in tissues of Crohn's Disease patients vs. healthy controls: 35
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 REG1A regenerating islet-derived 1 alpha Colon + 4.42 0.002
2 CXCL2 chemokine (C-X-C motif) ligand 2 Colon + 4.02 0.000
3 REG1B regenerating islet-derived 1 beta Colon + 3.99 0.008
4 LCN2 lipocalin 2 Colon + 3.90 0.000
5 REG3A regenerating islet-derived 3 alpha Colon + 3.74 0.026
6 CXCL11 chemokine (C-X-C motif) ligand 11 Colon + 3.70 0.016
7 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Colon + 3.60 0.000
8 CXCL8 chemokine (C-X-C motif) ligand 8 Colon + 3.50 0.004
9 DEFA6 defensin, alpha 6, Paneth cell-specific Colon + 3.49 0.029
10 S100A8 S100 calcium binding protein A8 Colon + 3.04 0.017
Search GEO for disease gene expression data for Crohn's Disease.

Pathways for Crohn's Disease

GO Terms for Crohn's Disease

Cellular components related to Crohn's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.47 ABCB1 CEACAM6 DUOX2 IL10RA IL10RB IL12RB2
2 apical plasma membrane GO:0016324 9.26 ABCB1 DUOX2 SLC22A4 SLC22A5

Biological processes related to Crohn's Disease according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.81 HP IRGM NOD2 SLC11A1
2 defense response to Gram-negative bacterium GO:0050829 9.7 IL23R IRGM SLC11A1
3 response to interferon-gamma GO:0034341 9.59 IL23R SLC11A1
4 positive regulation of interleukin-12 production GO:0032735 9.58 IL23R IRF5
5 organic anion transport GO:0015711 9.58 SLC22A4 SLC22A5
6 drug transmembrane transport GO:0006855 9.57 ABCB1 SLC22A5
7 positive regulation of interleukin-17 production GO:0032740 9.56 IL23R NOD2
8 response to muramyl dipeptide GO:0032495 9.55 IRF5 NOD2
9 maintenance of gastrointestinal epithelium GO:0030277 9.54 MUC2 NOD2
10 positive regulation of interferon-gamma production GO:0032729 9.5 IL12RB2 IL23R SLC11A1
11 positive regulation of T-helper 1 type immune response GO:0002827 9.49 IL23R SLC11A1
12 carnitine metabolic process GO:0009437 9.48 SLC22A4 SLC22A5
13 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.46 IRGM NOD2
14 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.43 NOD2 SLC11A1
15 carnitine transport GO:0015879 9.4 SLC22A4 SLC22A5
16 quaternary ammonium group transport GO:0015697 9.37 SLC22A4 SLC22A5
17 response to lipopolysaccharide GO:0032496 9.35 IL10RA IL12RB2 IL18BP IL23R SLC11A1
18 carnitine transmembrane transport GO:1902603 9.16 SLC22A4 SLC22A5
19 cytokine-mediated signaling pathway GO:0019221 9.02 DUOX2 IL10RA IL10RB IL12RB2 IRF5
20 protein lipidation involved in autophagosome assembly GO:0061739 8.96 IRGM

Molecular functions related to Crohn's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.62 ABCB1 SLC11A1 SLC22A4 SLC22A5
2 organic anion transmembrane transporter activity GO:0008514 9.4 SLC22A4 SLC22A5
3 CARD domain binding GO:0050700 9.37 IRGM NOD2
4 interleukin-10 receptor activity GO:0004920 9.26 IL10RA IL10RB
5 quaternary ammonium group transmembrane transporter activity GO:0015651 9.16 SLC22A4 SLC22A5
6 carnitine transmembrane transporter activity GO:0015226 8.96 SLC22A4 SLC22A5
7 cation:cation antiporter activity GO:0015491 8.62 SLC22A4 SLC22A5

Sources for Crohn's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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