MCID: CRN014
MIFTS: 46

Cronkhite-Canada Syndrome malady

Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases categories

Summaries for Cronkhite-Canada Syndrome

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42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Cronkhite-canada syndrome is a rare gastrointestinal disorder. it is characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, and stomach pain. the cause of the condition is not known. treatment aims to control symptoms and provide adequate nutrition. last updated: 12/20/2010

MalaCards: Cronkhite-Canada Syndrome, also known as gastric cronkhite canada polyposis, is related to diarrhea and adenoma, and has symptoms including polyposis of the bowel/colon/intestine, diffuse/generalised skin hyperpigmentation/melanoderma and absent/decreased/thin eyebrows. An important gene associated with Cronkhite-Canada Syndrome is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is Platelet activation, signaling and aggregation. The compounds erlotinib and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and olfactory bulb.

Description from OMIM:46 175500

Aliases & Classifications for Cronkhite-Canada Syndrome

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Sources:
8Disease Ontology, 48Orphanet, 46OMIM, 60UMLS, 42NIH Rare Diseases, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
cronkhite-canada syndrome:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

cronkhite-canada syndrome 8 48 46 60
gastric cronkhite canada polyposis 8 60
gastrointestinal polyposis - skin pigmentation - alopecia - fingernail changes 48
polyposis skin pigmentation alopecia fingernail changes 42
polyposis, gastrointestinal, with ectodermal changes 60
gastrointestinal polyposis - ectodermal changes 48
cronkhite-canada disease 42


External Ids:

Disease Ontology8 DOID:6225
NCIt39 C7035
OMIM46 175500
SNOMED-CT via Orphanet57 76304001
UMLS via Orphanet61 C0282207

Related Diseases for Cronkhite-Canada Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cronkhite-Canada Syndrome:



Diseases related to cronkhite-canada syndrome

Clinical Features for Cronkhite-Canada Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

175500

Clinical synopsis from OMIM:

175500

Symptoms:

48 (show all 28)
  • polyposis of the bowel/colon/intestine
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • absent/decreased/thin eyebrows
  • decreased body hair/axillar/pubic hairlessness
  • fissured/scrotal tongue
  • tapered fingers
  • dysplastic/thick/grooved fingernails
  • alopecia
  • dysplastic/thick/grooved toenails
  • anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia
  • neoplasms/tumors
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • seizures/epilepsy/absences/spasms/status epilepticus
  • cataract/lens opacification
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • vascular anomalies of skin/mucosae
  • malabsorption/chronic diarrhea/steatorrhea
  • asthenia/fatigue/weakness
  • anaemia
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • acute abdominal pain/colic
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • lymphedema
  • thin/hypoplastic/hyperconvex fingernails
  • thin/hypoplastic toenails
  • anorexia
  • macrocephaly/macrocrania/megalocephaly/megacephaly

Drugs & Therapeutics for Cronkhite-Canada Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cronkhite-Canada Syndrome

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Anatomical Context for Cronkhite-Canada Syndrome

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32MalaCards
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MalaCards organs/tissues related to Cronkhite-Canada Syndrome:

32
Skin, Colon, Olfactory bulb, Tongue, Liver, Bone, Brain

Animal Models for Cronkhite-Canada Syndrome or affiliated genes

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Publications for Cronkhite-Canada Syndrome

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50PubMed
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Articles related to Cronkhite-Canada Syndrome:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Cronkhite-Canada syndrome: a case report and review of literature. (23173699)
2013
2
Subtotal colectomy for severe protein-losing enteropathy associated with Cronkhite-Canada syndrome: a case report. (23323676)
2013
3
Cronkhite-Canada syndrome diagnosis in the absence of gastrointestinal polyps: a case report. (23515557)
2013
4
Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. (22675285)
2012
5
Cronkhite Canada syndrome with early colorectal carcinoma in a patient. (23240286)
2012
6
Case of Cronkhite Canada syndrome shows improvement with enteral supplements. (23029747)
2012
7
A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes. (22675284)
2012
8
Successful treatment for Cronkhite-Canada syndrome with endoscopic mucosal resection and salazosulfapyridine. (22847839)
2012
9
Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome. (22679262)
2011
10
Cronkhite-Canada syndrome associated with rib fractures: a case report. (20955587)
2010
11
Radiological features of Cronkhite-Canada syndrome. (20938600)
2010
12
Cecal intussusception in an adult with Cronkhite-Canada syndrome relieved by colonoscopy. (20558928)
2010
13
Magnifying the endoscopic appearance of Cronkhite-Canada syndrome. (19683713)
2009
14
Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. (18855786)
2008
15
Cronkhite-Canada syndrome associated with schizophrenia. (17301512)
2007
16
Is Cronkhite-Canada Syndrome necessarily a late-onset disease? (16148564)
2005
17
A case of Cronkhite-Canada syndrome with vestibular disturbances. (15014948)
2004
18
Cronkhite-Canada syndrome with adenomatous and carcinomatous transformation of colonic polyp. (14658536)
2003
19
Adenocarcinoma and multiple adenomas of the large intestine, associated with Cronkhite-Canada syndrome. (12868681)
2003
20
Cronkhite-Canada syndrome: sustained remission after corticosteroid treatment. (12818298)
2003
21
Cronkhite-Canada syndrome. A case of sustained partial-remission. (11838614)
2001
22
Cronkhite-Canada syndrome. (11428328)
2001
23
Cronkhite-Canada syndrome: report of two cases. (11023043)
2000
24
Case of the month: triple carcinomas in Cronkhite-Canada syndrome. (10418554)
1999
25
Surgical treatment of Cronkhite-Canada syndrome associated with protein-losing enteropathy: report of a case. (9678383)
1998
26
The Cronkhite-Canada Syndrome. A rare differential diagnosis of generalized gastrointestinal polyposis]. (9453910)
1997
27
Progressive ectodermal changes in the Cronkhite--Canada syndrome. (8918393)
1996
28
Cronkhite-Canada syndrome: epidemiological study of 110 cases reported in Japan. (8534187)
1995
29
The Cronkhite-Canada syndrome: a seldom recognized entity. (8076560)
1994
30
Cronkhite-Canada syndrome associated with colon cancer: report of a case. (8219618)
1993
31
Cronkhite-Canada syndrome associated with peripheral neuropathy. (1659357)
1991
32
Cronkhite-Canada syndrome with hypothyroidism. (2373535)
1990
33
Cronkhite Canada syndrome: case report with some features not previously described. (2335285)
1990
34
A case with some components of Cronkhite-Canada syndrome in a family with Peutz-Jeghers syndrome. (3154191)
1988
35
Cronkhite-Canada syndrome: an analysis of clinical features and follow-up studies of 80 cases reported in Japan. (3077242)
1988
36
Cronkhite-Canada syndrome. (3024934)
1987
37
Erosive arthritis in Cronkhite-Canada syndrome. (4011892)
1985
38
The Cronkhite-Canada syndrome: an ultrastructural study of pathogenesis. (3973050)
1985
39
Cronkhite-Canada syndrome associated with a rectal cancer and adenomatous changes in colonic polyps. (3970299)
1985
40
The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. (7109958)
1982
41
The radiographic appearance of the stomach in Cronkhite-Canada syndrome. (7291542)
1981
42
Cronkhite-Canada syndrome: report of a case with bacteriologic, immunologic, and electron microscopic studies. (7409392)
1980
43
'Chronic atrophic gastroenterocolitis': a variant of Cronkhite-Canada syndrome? (6893407)
1980
44
Cronkhite-Canada syndrome: report of an unusual case. (7409393)
1980
45
A patient with Cronkhite-Canada syndrome, myxedema and muscle atrophy. (433675)
1979
46
Cronkhite-Canada syndrome. Case report. (872063)
1977
47
Superficial cystic gastritis with alopecia. A forme fruste of the Cronkhite-Canada syndrome. (195553)
1977
48
Radiological aspect of Cronkhite-Canada syndrome. (4664355)
1972
49
Cronkhite-Canada syndrome. Radiological and endoscopic features. (4637352)
1972
50
Juvenile polyps with cachexia. Report of an infant and comparison with Cronkhite-Canada syndrome in adults. (4378049)
1969

Genetic Variations for Cronkhite-Canada Syndrome

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Expression for genes affiliated with Cronkhite-Canada Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cronkhite-Canada Syndrome

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Pathways for genes affiliated with Cronkhite-Canada Syndrome

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53Reactome
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Pathways related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ALB, KRAS

Compounds for genes affiliated with Cronkhite-Canada Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1erlotinib44 49 1111.2ALB, KRAS
2irinotecan44 49 1111.2ALB, KRAS
3gefitinib44 49 1111.1ALB, KRAS
4fatty acid449.1ALB, KRAS
5imatinib44 49 1111.0KRAS, ALB
6vitamin d448.8ALB, KRAS

GO Terms for genes affiliated with Cronkhite-Canada Syndrome

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16Gene Ontology
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Biological processes related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1ALB, KRAS

Products for genes affiliated with Cronkhite-Canada Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cronkhite-Canada Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet