MCID: CRN014
MIFTS: 50

Cronkhite-Canada Syndrome malady

Rare diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases categories
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Summaries for Cronkhite-Canada Syndrome

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43NIH Rare Diseases, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Cronkhite-canada syndrome is a rare gastrointestinal disorder. it is characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, and stomach pain. the cause of the condition is not known. treatment aims to control symptoms and provide adequate nutrition. last updated: 12/20/2010

MalaCards: Cronkhite-Canada Syndrome, also known as gastric cronkhite canada polyposis, is related to pancreatitis and adenoma, and has symptoms including polyposis of the bowel/colon/intestine, alopecia and diffuse/generalised skin hyperpigmentation/melanoderma. An important gene associated with Cronkhite-Canada Syndrome is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is Hemostasis. The compounds erlotinib and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and olfactory bulb, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Description from OMIM:47 175500

Aliases & Classifications for Cronkhite-Canada Syndrome

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Sources:
8Disease Ontology, 49Orphanet, 47OMIM, 62UMLS, 43NIH Rare Diseases, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
cronkhite-canada syndrome:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

cronkhite-canada syndrome 8 49 47 62
gastric cronkhite canada polyposis 8 62
gastrointestinal polyposis - skin pigmentation - alopecia - fingernail changes 49
polyposis skin pigmentation alopecia fingernail changes 43
polyposis, gastrointestinal, with ectodermal changes 62
gastrointestinal polyposis - ectodermal changes 49
cronkhite-canada disease 43


External Ids:

Disease Ontology8 DOID:6225
NCIt40 C7035
OMIM47 175500
SNOMED-CT via Orphanet59 76304001
UMLS via Orphanet63 C0282207

Related Diseases for Cronkhite-Canada Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cronkhite-Canada Syndrome:



Diseases related to cronkhite-canada syndrome

Symptoms for Cronkhite-Canada Syndrome

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47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

175500

Clinical features from OMIM:

175500

Symptoms:

49 (show all 28)
  • polyposis of the bowel/colon/intestine
  • alopecia
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • absent/decreased/thin eyebrows
  • decreased body hair/axillar/pubic hairlessness
  • fissured/scrotal tongue
  • tapered fingers
  • dysplastic/thick/grooved fingernails
  • dysplastic/thick/grooved toenails
  • anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia
  • neoplasms/tumors
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • seizures/epilepsy/absences/spasms/status epilepticus
  • cataract/lens opacification
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • vascular anomalies of skin/mucosae
  • malabsorption/chronic diarrhea/steatorrhea
  • asthenia/fatigue/weakness
  • anaemia
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • acute abdominal pain/colic
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • lymphedema
  • thin/hypoplastic/hyperconvex fingernails
  • thin/hypoplastic toenails
  • anorexia
  • macrocephaly/macrocrania/megalocephaly/megacephaly

Drugs & Therapeutics for Cronkhite-Canada Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cronkhite-Canada Syndrome

Search NIH Clinical Center for Cronkhite-Canada Syndrome

Genetic Tests for Cronkhite-Canada Syndrome

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Anatomical Context for Cronkhite-Canada Syndrome

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33MalaCards
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MalaCards organs/tissues related to Cronkhite-Canada Syndrome:

33
Skin, Colon, Olfactory bulb, Liver, Tongue, Brain, Bone

Animal Models for Cronkhite-Canada Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cronkhite-Canada Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.2KRAS, ALB
2MP:00053709.2KRAS, ALB
3MP:00053679.1KRAS, ALB
4MP:00053799.1KRAS, ALB
5MP:00053819.0ALB, KRAS
6MP:00053698.8KRAS, ALB

Publications for Cronkhite-Canada Syndrome

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Sources:
52PubMed
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Articles related to Cronkhite-Canada Syndrome:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Spontaneous Regression of Polyposis following Abdominal Colectomy and Helicobacter pylori Eradication for Cronkhite-Canada Syndrome. (23569441)
2013
2
Cronkhite-Canada syndrome: a report of two familial cases. (23408256)
2013
3
Cronkhite-Canada syndrome: a case report and review of literature. (23173699)
2013
4
A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. (24226722)
2013
5
Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. (23826450)
2013
6
Steroid-resistant Cronkhite-Canada Syndrome Successfully Treated by Cyclosporine and Azathioprine. (24172181)
2013
7
Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. (22675285)
2012
8
Cronkhite Canada syndrome with early colorectal carcinoma in a patient. (23240286)
2012
9
Case of Cronkhite Canada syndrome shows improvement with enteral supplements. (23029747)
2012
10
A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes. (22675284)
2012
11
Twenty nail onychomadesis: an unusual finding in Cronkhite-Canada syndrome. (20542187)
2010
12
Cronkhite-Canada syndrome associated with rib fractures: a case report. (20955587)
2010
13
Magnifying the endoscopic appearance of Cronkhite-Canada syndrome. (19683713)
2009
14
Cronkhite-Canada syndrome with adenomatous polyposis. (18480533)
2008
15
Unusual cause of diarrhea: cronkhite-Canada syndrome. (18356114)
2008
16
Cronkhite Canada syndrome. (19051706)
2008
17
Electronic clinical challenges and images in GI. Cronkhite-Canada syndrome. (19013171)
2008
18
Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells. (17510553)
2007
19
Cronkhite-Canada syndrome associated with schizophrenia. (17301512)
2007
20
Wireless capsule endoscopic finding in Cronkhite-Canada syndrome. (16698761)
2006
21
A case of Cronkhite-Canada syndrome with vestibular disturbances. (15014948)
2004
22
Cronkhite-Canada syndrome. (15332040)
2004
23
Novel endosonographic findings in Cronkhite-Canada syndrome. (12701028)
2003
24
Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. (14505136)
2003
25
Medical management of Cronkhite-Canada syndrome. (11846261)
2002
26
A case of Cronkhite-Canada syndrome involving the entire gastrointestinal tract. (11315906)
2001
27
Cronkhite-Canada syndrome. A case of sustained partial-remission. (11838614)
2001
28
Cronkhite-Canada syndrome. (11428328)
2001
29
Cronkhite-Canada syndrome associated with advanced rectal cancer treated by a subtotal colectomy: report of a case. (11428606)
2001
30
Cronkhite-Canada syndrome: report of two cases. (11023043)
2000
31
Cronkhite Canada syndrome. (11310396)
2000
32
Residents' corner. Answer to case of the month #64. Cronkhite-Canada syndrome. (10555512)
1999
33
Image of the month. Cronkhite-Canada syndrome. (9394720)
1997
34
Infantile Cronkhite-Canada syndrome?--Case report. (1329940)
1992
35
Triple carcinomas in Cronkhite-Canada syndrome. (1942550)
1991
36
Cronkhite-Canada syndrome with hypothyroidism. (2373535)
1990
37
Cronkhite-Canada syndrome: radiologic features. (2680733)
1989
38
A case with some components of Cronkhite-Canada syndrome in a family with Peutz-Jeghers syndrome. (3154191)
1988
39
Cronkhite-Canada syndrome associated with colon carcinoma and adenomatous changes in C-C polyps. (3381811)
1988
40
Cronkhite Canada syndrome: a new hypothesis. (3996943)
1985
41
Erosive arthritis in Cronkhite-Canada syndrome. (4011892)
1985
42
The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. (7109958)
1982
43
A case of Cronkhite-Canada syndrome developing after hemi-colectomy. (7297517)
1981
44
Cronkhite-Canada syndrome in a Malay. (760669)
1979
45
Cronkhite-Canada syndrome. Case report. (872063)
1977
46
An autopsy case of Cronkhite-Canada syndrome. (992257)
1976
47
Two autopsy cases of diffuse gastrointestinal polyposis with ectodermal changes. Cronkhite-Canada syndrome. (1211385)
1975
48
The Cronkhite-Canada syndrome. (4635110)
1972
49
Radiological aspect of Cronkhite-Canada syndrome. (4664355)
1972
50
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969

Variations for Cronkhite-Canada Syndrome

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Expression for genes affiliated with Cronkhite-Canada Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cronkhite-Canada Syndrome

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Pathways for genes affiliated with Cronkhite-Canada Syndrome

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50PathCards, 55Reactome
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Pathways related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1KRAS, ALB

Compounds for genes affiliated with Cronkhite-Canada Syndrome

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45Novoseek, 51PharmGKB, 11DrugBank
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Compounds related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1erlotinib45 51 1111.3KRAS, ALB
2gefitinib45 51 1111.2KRAS, ALB
3irinotecan45 51 1111.2KRAS, ALB
4imatinib45 51 1111.1ALB, KRAS
5lipid459.1KRAS, ALB
6vitamin d459.0KRAS, ALB
7fatty acid458.8KRAS, ALB

GO Terms for genes affiliated with Cronkhite-Canada Syndrome

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16Gene Ontology
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Biological processes related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1KRAS, ALB

Products for genes affiliated with Cronkhite-Canada Syndrome

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  • Antibodies

Sources for Cronkhite-Canada Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet