MCID: CRN014
MIFTS: 43

Cronkhite-Canada Syndrome malady

Categories: Rare diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Cronkhite-Canada Syndrome

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Aliases & Descriptions for Cronkhite-Canada Syndrome:

Name: Cronkhite-Canada Syndrome 10 12 51 65
Gastric Cronkhite Canada Polyposis 10 65
Gastrointestinal Polyposis-Skin Pigmentation-Alopecia-Fingernail Changes Syndrome 51
Polyposis Skin Pigmentation Alopecia Fingernail Changes 45
 
Gastrointestinal Polyposis-Ectodermal Changes Syndrome 51
Polyposis, Gastrointestinal, with Ectodermal Changes 65
Cronkhite-Canada Disease 45

Characteristics:

Orphanet epidemiological data:

51
cronkhite-canada syndrome:
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:6225
NCIt42 C7035
Orphanet51 2930
UMLS via Orphanet66 C0282207
UMLS65 C1333764, C0282207, C0238386

Summaries for Cronkhite-Canada Syndrome

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NIH Rare Diseases:45 Cronkhite-canada syndrome is a rare gastrointestinal disorder characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, stomach pain, and/or excess fluid accumulation in arms and legs (peripheral edema). the cause of the condition is not known. treatment aims to control symptoms and provide adequate nutrition. last updated: 5/31/2015

MalaCards based summary: Cronkhite-Canada Syndrome, also known as gastric cronkhite canada polyposis, is related to esophagitis and cervical dystonia, and has symptoms including hamartoma/tumefaction of the tongue/gingivae/oral mucosa, abnormal pigmentary skin changes/skin pigmentation anomalies and diffuse/generalised skin hyperpigmentation/melanoderma. An important gene associated with Cronkhite-Canada Syndrome is ALB (Albumin), and among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Integrated Breast Cancer Pathway. Affiliated tissues include skin, colon and tongue, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Related Diseases for Cronkhite-Canada Syndrome

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Diseases related to Cronkhite-Canada Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis30.7ATP12A, ATP4A
2cervical dystonia30.7ATP12A, ATP4A
3hepatocellular carcinoma29.6ALB, PTEN, SERPINA1, TP53
4systemic lupus erythematosus10.4
5breast cancer10.4
6hepatitis10.4
7prostatitis10.4
8syringoma10.4
9cervicitis10.4
10cerebritis10.4
11mediastinitis10.4
12lupus erythematosus10.4
13amyloidosis10.4
14distal 10q deletion syndrome10.4BMPR1A, PTEN
15familial drusen10.4BMPR1A, PTEN
16glioma susceptibility 210.4BMPR1A, PTEN
17hemopericardium10.4ALB, SERPINA1
18orofaciodigital syndrome iii10.3ALB, SERPINA1
19cowden syndrome 610.3BMPR1A, PTEN
20allergic urticaria10.3ALB, SERPINA1
21hyperinsulinism-hyperammonemia syndrome10.3BMPR1A, PTEN
22bacterial gastritis10.3ALB, ATP4A
23black piedra10.3ALB, ATP4A
24pulmonary aspergilloma10.3ALB, ATP4A
25microinvasive gastric cancer10.3ALB, ATP4A
26schizophrenia10.3
27gastrointestinal stromal tumor10.3
28neuroblastoma10.3
29parathyroid carcinoma10.3
30hiv-110.3
31asthma10.3
32synesthesia10.3
33obesity10.3
34west nile virus10.3
35attention deficit-hyperactivity disorder10.3
36colchicine resistance10.3
37chordoma10.3
38aspergillosis10.3
39pseudohypoparathyroidism, type ib10.3
40incontinentia pigmenti10.3
41twin-to-twin transfusion syndrome10.3
42aortic atherosclerosis10.3
43atherosclerosis10.3
44autoimmune hepatitis10.3
45charcot-marie-tooth disease10.3
46hemolytic anemia10.3
47intermittent claudication10.3
48leukemia10.3
49spinal stenosis10.3
50fusariosis10.3

Graphical network of the top 20 diseases related to Cronkhite-Canada Syndrome:



Diseases related to cronkhite-canada syndrome

Symptoms for Cronkhite-Canada Syndrome

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Symptoms:

 51 (show all 44)
  • hamartoma/tumefaction of the tongue/gingivae/oral mucosa
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • alopecia
  • thin/hypoplastic/hyperconvex fingernails
  • dysplastic/thick/grooved fingernails
  • thin/hypoplastic toenails
  • dysplastic/thick/grooved toenails
  • abnormal nails colour/leukonychia/melanonychia
  • polyposis of the bowel/colon/intestine
  • malabsorption/chronic diarrhea/steatorrhea
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • absent/decreased/thin eyebrows
  • irregular/patchy skin hypopigmentation
  • vascular anomalies of skin/mucosae
  • decreased body hair/axillar/pubic hairlessness
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • lymphedema
  • anorexia
  • autoimmunity/autoimmune reaction/autoantibodies
  • anaemia
  • small bowel neoplasm/tumor/carcinoma/cancer
  • asthenia/fatigue/weakness
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • cataract/lens opacification
  • anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia
  • fissured/scrotal tongue
  • tapered fingers
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • heart/cardiac failure
  • renal glomerular defect/glomerulopathy
  • hypothyroidy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hypoproteinemia
  • neoplasms/tumors
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • early death/lethality

Drugs & Therapeutics for Cronkhite-Canada Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Cronkhite-Canada Syndrome

Genetic Tests for Cronkhite-Canada Syndrome

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Anatomical Context for Cronkhite-Canada Syndrome

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MalaCards organs/tissues related to Cronkhite-Canada Syndrome:

33
Skin, Colon, Tongue, Liver, Heart, Olfactory bulb, Bone

Animal Models for Cronkhite-Canada Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Cronkhite-Canada Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ALB, BMPR1A, MUC2, PTEN, TP53
2MP:00053798.1ALB, ATP4A, BMPR1A, MUC2, PTEN, TP53
3MP:00053816.6ALB, ATP12A, ATP4A, MUC2, MUC5AC, PTEN
4MP:00053766.5ALB, ATP12A, ATP4A, BMPR1A, MUC2, MUC5AC

Publications for Cronkhite-Canada Syndrome

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Articles related to Cronkhite-Canada Syndrome:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Improved Diagnosis of Prosthetic Joint Infection by Culturing Periprosthetic Tissue Specimens in Blood Culture Bottles. (26733067)
2016
2
MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma. (26251675)
2015
3
Biomechanical effect of transforaminal lumbar interbody fusion and axial interbody threaded rod on range of motion and s1 screw loading in a destabilized L5-s1 spondylolisthesis model. (24150429)
2014
4
Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility. (25252845)
2014
5
Insights into TREM2 biology by network analysis of human brain gene expression data. (23855984)
2013
6
Efficacy and safety of deferasirox in myelodysplastic syndromes. (23417759)
2013
7
The effect of delayed percutaneous nephrolithotomy on the risk of bacteremia and sepsis in patients with neuromuscular disorders. (23443410)
2013
8
Comparison of outcome between older and younger patients following surgery for primary hyperparathyroidism. (24310763)
2013
9
Myasthenia gravis, schizophrenia, and colorectal cancer in a patient: long-term follow-up with medication complexity. (24302955)
2013
10
What lies beneath: Posterior ST elevation myocardial infarction with underlying right ventricular-paced rhythm. (24294052)
2013
11
Remarkable cystic expansion of microprolactinoma causing diabetes insipidus during pregnancy. (22593591)
2012
12
B-cell chronic lymphocytic leukaemia presenting as lower motor neuron disease and SS. (22389126)
2012
13
Transverse sinus stenting for idiopathic intracranial hypertension: a review of 52 patients and of model predictions. (21799038)
2011
14
Effect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphism. (21801125)
2011
15
Sleep disorder and cardiovascular risk factors among patients with type 2 diabetes mellitus. (22016588)
2011
16
Single-center experience with rituximab as first-line immunosuppression for acquired hemophilia. (21575131)
2011
17
Vascular endothelial growth factor +405 G/C,-460 T/C and -2578 A/C polymorphisms are not associated with insulin resistance in polycystic ovary syndrome. (20477880)
2010
18
Histiocytic sarcoma with interdigitating dendritic cell differentiation: a case report with fine needle aspiration cytology and review of literature. (19845032)
2010
19
Impedance audiometry in infants with a cleft palate: the standard 226-Hz probe tone has no predictive value for the middle ear condition. (20381885)
2010
20
A first report of collagenous gastritis, sprue, and colitis in a 9-month-old infant: 14 years of clinical, endoscopic, and histologic follow-up. (19757370)
2009
21
Cytogenetic evidence of metastatic myxoid liposarcoma and therapy-related myelodysplastic syndrome in a bone marrow biopsy. (19439345)
2009
22
Lack of HER-2 gene amplification in non-Hodgkin lymphoma using chromogenic in situ hybridisation test. (19452317)
2009
23
DISC1-kendrin interaction is involved in centrosomal microtubule network formation. (18955030)
2008
24
Regulation of mitochondrial mRNA stability by RNase L is translation-dependent and controls IFNalpha-induced apoptosis. (17431428)
2007
25
Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction. (18087239)
2007
26
Does HER2 immunoreactivity provide prognostic information in locally advanced urothelial carcinoma patients receiving adjuvant M-VEC chemotherapy? (17940352)
2007
27
Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples. (17080715)
2006
28
Characterisation of cryopreserved cells freshly isolated from human bone marrow. (16691306)
2006
29
Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs. (16261825)
2005
30
Effect of fluoridation of hydroxyapatite in hydroxyapatite-polycaprolactone composites on osteoblast activity. (15701368)
2005
31
Signaling mechanisms mediated by G-protein coupled receptors in human platelets. (15210061)
2004
32
Infection of primary human macrophages with hepatitis C virus in vitro: induction of tumour necrosis factor-alpha and interleukin 8. (14718619)
2004
33
Effects of neoadjuvant chemotherapy on estrogen and progesterone receptors and HER-2 in breast cancer]. (15604081)
2004
34
Ca2+-independent phospholipases A2 and production of arachidonic acid in nuclei of LA-N-1 cell cultures: a specific receptor activation mediated with retinoic acid. (12877989)
2003
35
New in vitro model to study high glucose-dependent endothelial dysfunctions. (14505826)
2003
36
Conservative management of intrahepatic perforation of the gallbladder secondary to acalculous cholecystitis. (14618527)
2003
37
CD40, CD154, Bax and Bcl-2 expression in SjAPgren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. (12472667)
2002
38
Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells. (11752227)
2002
39
Mechanism of the immune response to human factor VIII in murine hemophilia A. (11204564)
2001
40
Positive response to therapy in a patient with a seropositive paraneoplastic cerebellar degeneration and an endometrioid carcinoma of the vesicovaginal septum. (10577031)
1999
41
Long-term survival after resection of proximal bile duct carcinoma (Klatskin tumors). (9841770)
1999
42
Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators. (9056059)
1997
43
Fine needle aspiration cytology of cystic partially differentiated nephroblastoma. A case report. (8693903)
1996
44
Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure. (7882493)
1995
45
Naturally occurring autoantibodies to interleukin-1 alpha, interleukin-6, interleukin-10, and interferon-alpha. (7822860)
1994
46
Risperidone. (7524043)
1994
47
Differences in 2-oxoglutarate dehydrogenase regulation in liver and kidney. (8240307)
1993
48
The discriminative stimulus properties of acute ethanol withdrawal (hangover) in rats. (1590555)
1992
49
An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma. (2472127)
1989
50
Sebaceous carcinoma of the eyelid masquerading as superior limbic keratoconjunctivitis. (4051856)
1985

Variations for Cronkhite-Canada Syndrome

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Expression for genes affiliated with Cronkhite-Canada Syndrome

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Search GEO for disease gene expression data for Cronkhite-Canada Syndrome.

Pathways for genes affiliated with Cronkhite-Canada Syndrome

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Pathways related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4ALB, BMPR1A, SERPINA1
29.1BMPR1A, PTEN, TP53

GO Terms for genes affiliated with Cronkhite-Canada Syndrome

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Biological processes related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium ion importGO:00101079.4ATP12A, ATP4A

Molecular functions related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5ALB, TP53

Sources for Cronkhite-Canada Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet