MCID: CRN014
MIFTS: 46

Cronkhite-Canada Syndrome malady

Rare diseases, Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases categories

Aliases & Classifications for Cronkhite-Canada Syndrome

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 65UMLS, 42NCIt, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Cronkhite-Canada Syndrome:

Name: Cronkhite-Canada Syndrome 10 12 51 65
Gastric Cronkhite Canada Polyposis 10 65
Gastrointestinal Polyposis - Skin Pigmentation - Alopecia - Fingernail Changes 51
Polyposis Skin Pigmentation Alopecia Fingernail Changes 45
 
Polyposis, Gastrointestinal, with Ectodermal Changes 65
Gastrointestinal Polyposis - Ectodermal Changes 51
Cronkhite-Canada Disease 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
cronkhite-canada syndrome:
Inheritance: Not applicable; Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology10 DOID:6225
NCIt42 C7035
Orphanet51 2930
UMLS via Orphanet66 C0282207

Summaries for Cronkhite-Canada Syndrome

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NIH Rare Diseases:45 Cronkhite-canada syndrome is a rare gastrointestinal disorder characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, stomach pain, and/or excess fluid accumulation in arms and legs (peripheral edema). the cause of the condition is not known. treatment aims to control symptoms and provide adequate nutrition. last updated: 5/31/2015

MalaCards based summary: Cronkhite-Canada Syndrome, also known as gastric cronkhite canada polyposis, is related to eosinophilic gastroenteritis and pancreatitis, and has symptoms including hamartoma/tumefaction of the tongue/gingivae/oral mucosa, abnormal pigmentary skin changes/skin pigmentation anomalies and diffuse/generalised skin hyperpigmentation/melanoderma. An important gene associated with Cronkhite-Canada Syndrome is ALB (Albumin), and among its related pathways are Thyroid cancer and mTOR Pathway. Affiliated tissues include skin, colon and tongue, and related mouse phenotypes are pigmentation and muscle.

Related Diseases for Cronkhite-Canada Syndrome

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Diseases related to Cronkhite-Canada Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilic gastroenteritis30.5ATP12A, ATP4A
2pancreatitis30.4MUC2, MUC5AC
3esophagitis30.4ATP12A, ATP4A, TP53
4gastric cancer10.7
5adenoma10.7
6protein-losing enteropathy10.6
7alopecia10.5
8adenocarcinoma10.4
9hypothyroidism10.4
10reticulohistiocytic granuloma10.3ALB, TP53
11cataract - intellectual disability - hypogonadism10.3KRAS, TP53
12childhood brain germinoma10.3ALB, BMPR1A
13myh9-related disorders10.3KRAS, TP53
14schizophrenia10.3
15myelodysplastic syndrome10.3
16peutz-jeghers syndrome10.3
17arthritis10.3
18cataract10.3
19colorectal adenoma10.3
20glomerulonephritis10.3
21villous adenocarcinoma10.3
22acute pancreatitis10.3
23myxedema10.3
24membranous glomerulonephritis10.3
25intussusception10.3
26colon adenoma10.3
27colitis10.3
28diarrhea10.3
29gastritis10.3
30gastroenteritis10.3
31neuropathy10.3
32peripheral neuropathy10.3
33vasculitis10.3
34kidney hemangiopericytoma10.3KRAS, TP53
35pancreatic islet cell tumors10.3KRAS, TP53
36mature teratoma of the ovary10.3KRAS, TP53
37toxic encephalopathy10.3KRAS, TP53
38peripheral focal chorioretinitis10.3ALB, TP53
39pulmonary embolism10.2KRAS, TP53
40chest wall lymphoma10.2PTEN, TP53
41sublingual gland adenoid cystic carcinoma10.2KRAS, PTEN
42foix-alajouanine syndrome10.2BMPR1A, PTEN
43ovary epithelial cancer10.2KRAS, TP53
44mixed epithelial tumor of ovary10.2KRAS, TP53
45acantholytic variant squamous cell breast carcinoma10.2PTEN, TP53
46bannayan-riley-ruvalcaba syndrome10.2BMPR1A, PTEN
47hemopericardium10.2ALB, SERPINA1
48ovarian mucinous cystadenocarcinoma10.2KRAS, MUC2
49endogenous depression10.2ALB, SERPINA1
50fallopian tube squamous cell carcinoma10.2KRAS, TP53

Graphical network of the top 20 diseases related to Cronkhite-Canada Syndrome:



Diseases related to cronkhite-canada syndrome

Symptoms for Cronkhite-Canada Syndrome

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Symptoms:

 51 (show all 44)
  • hamartoma/tumefaction of the tongue/gingivae/oral mucosa
  • abnormal pigmentary skin changes/skin pigmentation anomalies
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • alopecia
  • thin/hypoplastic/hyperconvex fingernails
  • dysplastic/thick/grooved fingernails
  • thin/hypoplastic toenails
  • dysplastic/thick/grooved toenails
  • abnormal nails colour/leukonychia/melanonychia
  • polyposis of the bowel/colon/intestine
  • malabsorption/chronic diarrhea/steatorrhea
  • estomach/gastric neoplasm/tumor/carcinoma/cancer
  • colon neoplasm/tumor/carcinoma/cancer
  • absent/decreased/thin eyebrows
  • irregular/patchy skin hypopigmentation
  • vascular anomalies of skin/mucosae
  • decreased body hair/axillar/pubic hairlessness
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • lymphedema
  • anorexia
  • autoimmunity/autoimmune reaction/autoantibodies
  • anaemia
  • small bowel neoplasm/tumor/carcinoma/cancer
  • asthenia/fatigue/weakness
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • cataract/lens opacification
  • anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia
  • fissured/scrotal tongue
  • tapered fingers
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • heart/cardiac failure
  • renal glomerular defect/glomerulopathy
  • hypothyroidy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hypoproteinemia
  • neoplasms/tumors
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • early death/lethality

Drugs & Therapeutics for Cronkhite-Canada Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Cronkhite-Canada Syndrome

Genetic Tests for Cronkhite-Canada Syndrome

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Anatomical Context for Cronkhite-Canada Syndrome

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MalaCards organs/tissues related to Cronkhite-Canada Syndrome:

33
Skin, Colon, Tongue, Olfactory bulb, Heart, Liver, Small intestine

Animal Models for Cronkhite-Canada Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Cronkhite-Canada Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4BMPR1A, KRAS, PTEN, TP53
2MP:00053698.9ALB, BMPR1A, KRAS, PTEN, TP53
3MP:00053678.7ALB, ATP12A, KRAS, PTEN, TP53
4MP:00020068.3ALB, BMPR1A, KRAS, MUC2, PTEN, TP53
5MP:00053798.3ALB, BMPR1A, KRAS, MUC2, PTEN, TP53
6MP:00053816.9ALB, ATP12A, ATP4A, KRAS, MUC2, MUC5AC
7MP:00053876.8ATP4A, BMPR1A, KRAS, MUC2, MUC5AC, PTEN
8MP:00053766.2ALB, ATP12A, ATP4A, BMPR1A, KRAS, MUC2

Publications for Cronkhite-Canada Syndrome

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Articles related to Cronkhite-Canada Syndrome:

(show top 50)    (show all 157)
idTitleAuthorsYear
1
Cronkhite-Canada Syndrome (CCS)-A Rare Case Report. (25954656)
2015
2
Cronkhite-Canada syndrome showing elevated levels of antinuclear and anticentromere antibody. (25518819)
2015
3
A Case of Cronkhite-Canada Syndrome with a Colitis-mimicking Endoscopic Presentation. (26363517)
2015
4
Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. (26216651)
2015
5
Cronkhite-Canada syndrome: report of six cases and review of literature. (24966624)
2014
6
Spontaneous Regression of Polyposis following Abdominal Colectomy and Helicobacter pylori Eradication for Cronkhite-Canada Syndrome. (23569441)
2013
7
Cronkhite-Canada syndrome: a report of two familial cases. (23408256)
2013
8
Cronkhite-Canada syndrome: a case report and review of literature. (23173699)
2013
9
A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. (24226722)
2013
10
Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. (23826450)
2013
11
Steroid-resistant Cronkhite-Canada Syndrome Successfully Treated by Cyclosporine and Azathioprine. (24172181)
2013
12
Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. (22675285)
2012
13
Cronkhite Canada syndrome with early colorectal carcinoma in a patient. (23240286)
2012
14
Case of Cronkhite Canada syndrome shows improvement with enteral supplements. (23029747)
2012
15
A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes. (22675284)
2012
16
Twenty nail onychomadesis: an unusual finding in Cronkhite-Canada syndrome. (20542187)
2010
17
Cronkhite-Canada syndrome associated with rib fractures: a case report. (20955587)
2010
18
Magnifying the endoscopic appearance of Cronkhite-Canada syndrome. (19683713)
2009
19
Cronkhite-Canada syndrome with adenomatous polyposis. (18480533)
2008
20
Unusual cause of diarrhea: cronkhite-Canada syndrome. (18356114)
2008
21
Cronkhite Canada syndrome. (19051706)
2008
22
Electronic clinical challenges and images in GI. Cronkhite-Canada syndrome. (19013171)
2008
23
Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells. (17510553)
2007
24
Cronkhite-Canada syndrome associated with schizophrenia. (17301512)
2007
25
Wireless capsule endoscopic finding in Cronkhite-Canada syndrome. (16698761)
2006
26
A case of Cronkhite-Canada syndrome with vestibular disturbances. (15014948)
2004
27
Novel endosonographic findings in Cronkhite-Canada syndrome. (12701028)
2003
28
Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. (14505136)
2003
29
A case of Cronkhite-Canada syndrome involving the entire gastrointestinal tract. (11315906)
2001
30
Cronkhite-Canada syndrome. A case of sustained partial-remission. (11838614)
2001
31
Cronkhite-Canada syndrome. (11428328)
2001
32
Cronkhite-Canada syndrome: report of two cases. (11023043)
2000
33
Cronkhite Canada syndrome. (11310396)
2000
34
Cronkhite-Canada syndrome: report of two cases, biopsy findings in the associated alopecia, and a new treatment option. (9564598)
1998
35
Triple carcinomas in Cronkhite-Canada syndrome. (1942550)
1991
36
Cronkhite-Canada syndrome with hypothyroidism. (2373535)
1990
37
Cronkhite-Canada syndrome: radiologic features. (2680733)
1989
38
A case with some components of Cronkhite-Canada syndrome in a family with Peutz-Jeghers syndrome. (3154191)
1988
39
Cronkhite-Canada syndrome associated with colon carcinoma and adenomatous changes in C-C polyps. (3381811)
1988
40
Cronkhite Canada syndrome: a new hypothesis. (3996943)
1985
41
Erosive arthritis in Cronkhite-Canada syndrome. (4011892)
1985
42
The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. (7109958)
1982
43
A case of Cronkhite-Canada syndrome developing after hemi-colectomy. (7297517)
1981
44
Cronkhite-Canada syndrome in a Malay. (760669)
1979
45
Cronkhite-Canada syndrome. Case report. (872063)
1977
46
An autopsy case of Cronkhite-Canada syndrome. (992257)
1976
47
Two autopsy cases of diffuse gastrointestinal polyposis with ectodermal changes. Cronkhite-Canada syndrome. (1211385)
1975
48
The Cronkhite-Canada syndrome. (4635110)
1972
49
Radiological aspect of Cronkhite-Canada syndrome. (4664355)
1972
50
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969

Variations for Cronkhite-Canada Syndrome

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Expression for genes affiliated with Cronkhite-Canada Syndrome

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Search GEO for disease gene expression data for Cronkhite-Canada Syndrome.

Pathways for genes affiliated with Cronkhite-Canada Syndrome

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Pathways related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KRAS, TP53
2
Show member pathways
9.4BMPR1A, KRAS, TP53
39.4KRAS, PTEN, TP53
49.4KRAS, PTEN, TP53
59.4KRAS, PTEN, TP53
69.4KRAS, PTEN, TP53
79.4KRAS, PTEN, TP53
89.0BMPR1A, KRAS, PTEN, TP53

GO Terms for genes affiliated with Cronkhite-Canada Syndrome

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Biological processes related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of cellular senescenceGO:200077210.3BMPR1A, TP53
2embryonic organ developmentGO:004856810.3BMPR1A, TP53
3cellular sodium ion homeostasisGO:00068839.7ATP12A, ATP4A
4potassium ion importGO:00101079.7ATP12A, ATP4A
5sodium ion export from cellGO:00363769.7ATP12A, ATP4A
6ATP hydrolysis coupled proton transportGO:00159919.7ATP12A, ATP4A
7cellular potassium ion homeostasisGO:00300079.7ATP12A, ATP4A
8blood coagulationGO:00075969.0ALB, KRAS, SERPINA1, TP53

Molecular functions related to Cronkhite-Canada Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hydrogen:potassium-exchanging ATPase activityGO:00089009.4ATP12A, ATP4A
2sodium:potassium-exchanging ATPase activityGO:00053919.3ATP12A, ATP4A

Sources for Cronkhite-Canada Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet