MCID: CRN014
MIFTS: 46

Cronkhite-Canada Syndrome malady

Gastrointestinal diseases, Skin diseases, Fetal diseases, Cancer diseases categories

Summaries for Cronkhite-Canada Syndrome

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42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Cronkhite-canada syndrome is a rare gastrointestinal disorder. it is characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, and stomach pain. the cause of the condition is not known. treatment aims to control symptoms and provide adequate nutrition. last updated: 12/20/2010

MalaCards: Cronkhite-Canada Syndrome, also known as gastric cronkhite canada polyposis, is related to diarrhea and adenoma, and has symptoms including cataract/lens opacification, anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia and fissured/scrotal tongue. An important gene associated with Cronkhite-Canada Syndrome is KRAS (Kirsten rat sarcoma viral oncogene homolog), and among its related pathways is Platelet activation, signaling and aggregation. The compounds erlotinib and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and tongue.

Description from OMIM:46 175500

Aliases & Classifications for Cronkhite-Canada Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 46OMIM, 60UMLS, 39NCIt, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
cronkhite-canada syndrome:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Any age


Aliases & Descriptions:

cronkhite-canada syndrome 8 48 46 60
gastric cronkhite canada polyposis 8 60
gastrointestinal polyposis - skin pigmentation - alopecia - fingernail changes 48
polyposis skin pigmentation alopecia fingernail changes 42
polyposis, gastrointestinal, with ectodermal changes 60
gastrointestinal polyposis - ectodermal changes 48
cronkhite-canada disease 42


External Ids:

Disease Ontology8 DOID:6225
NCIt39 C7035
OMIM46 175500
SNOMED-CT via Orphanet57 76304001
UMLS via Orphanet61 C0282207

Related Diseases for Cronkhite-Canada Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cronkhite-Canada Syndrome:



Diseases related to cronkhite-canada syndrome

Clinical Features for Cronkhite-Canada Syndrome

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46OMIM, 48Orphanet
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Clinical features from OMIM:

175500

Clinical synopsis from OMIM:

175500

Symptoms:

48 (show all 28)
  • cataract/lens opacification
  • anosmia/cacosmia/hypogeusia/hyposmia/olfactory bulb hypoplasia
  • fissured/scrotal tongue
  • tapered fingers
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • seizures/epilepsy/absences/spasms/status epilepticus
  • neoplasms/tumors
  • wasted (excluding lipodystrophy)/poorly muscled build/cachexy
  • macrocephaly/macrocrania/megalocephaly/megacephaly
  • asthenia/fatigue/weakness
  • anaemia
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • alopecia
  • thin/hypoplastic/hyperconvex fingernails
  • dysplastic/thick/grooved fingernails
  • thin/hypoplastic toenails
  • dysplastic/thick/grooved toenails
  • polyposis of the bowel/colon/intestine
  • malabsorption/chronic diarrhea/steatorrhea
  • absent/decreased/thin eyebrows
  • vascular anomalies of skin/mucosae
  • decreased body hair/axillar/pubic hairlessness
  • acute abdominal pain/colic
  • lymphedema
  • anorexia
  • abnormal pigmentary skin changes/skin pigmentation anomalies

Drugs & Therapeutics for Cronkhite-Canada Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Cronkhite-Canada Syndrome

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Anatomical Context for Cronkhite-Canada Syndrome

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32MalaCards
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MalaCards organs/tissues related to Cronkhite-Canada Syndrome:

32
Skin, Colon, Tongue, Olfactory bulb, Liver, Bone, Brain

Animal Models for Cronkhite-Canada Syndrome or affiliated genes

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Publications for Cronkhite-Canada Syndrome

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Sources:
50PubMed
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Articles related to Cronkhite-Canada Syndrome:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Cronkhite-Canada syndrome: a report of two familial cases. (23408256)
2013
2
Cronkhite-Canada syndrome: a case report and review of literature. (23173699)
2013
3
Cronkhite-Canada Syndrome: Review of the Literature. (24369458)
2013
4
Cronkhite-Canada syndrome diagnosis in the absence of gastrointestinal polyps: a case report. (23515557)
2013
5
Cronkhite-Canada syndrome: an acquired condition of gastrointestinal polyposis and dermatologic abnormalities. (22675285)
2012
6
A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes. (22675284)
2012
7
Cronkhite-Canada syndrome associated with a giant cell bone tumor. (23256113)
2012
8
Diarrhoea, weight loss and polyposis: think Cronkhite-Canada syndrome. (22679262)
2011
9
A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. (20887986)
2011
10
Radiological features of Cronkhite-Canada syndrome. (20938600)
2010
11
Cecal intussusception in an adult with Cronkhite-Canada syndrome relieved by colonoscopy. (20558928)
2010
12
A fulminant course of Cronkhite-Canada syndrome. (21170844)
2010
13
Magnifying the endoscopic appearance of Cronkhite-Canada syndrome. (19683713)
2009
14
Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. (18855786)
2008
15
CT endoscopy for the follow-up of Cronkhite-Canada syndrome. (16680416)
2007
16
A case of Cronkhite-Canada syndrome with colorectal adenomas: effect of the nonsteroidal anti-inflammatory drug sulindac. (17686082)
2007
17
A case of Cronkhite-Canada syndrome with taste disturbance as a leading complaint. (15942207)
2005
18
Is Cronkhite-Canada Syndrome necessarily a late-onset disease? (16148564)
2005
19
A case of Cronkhite-Canada syndrome with vestibular disturbances. (15014948)
2004
20
Cronkhite-Canada syndrome with adenomatous and carcinomatous transformation of colonic polyp. (14658536)
2003
21
Cronkhite-Canada syndrome: sustained remission after corticosteroid treatment. (12818298)
2003
22
Cronkhite-Canada syndrome. A case of sustained partial-remission. (11838614)
2001
23
Cronkhite-Canada syndrome: report of two cases. (11023043)
2000
24
Cronkhite Canada syndrome. (11310396)
2000
25
Infantile Cronkhite-Canada syndrome. (10771847)
1997
26
The Cronkhite-Canada Syndrome. A rare differential diagnosis of generalized gastrointestinal polyposis]. (9453910)
1997
27
The Cronkhite-Canada syndrome: a seldom recognized entity. (8076560)
1994
28
Cronkhite-Canada syndrome associated with colon cancer: report of a case. (8219618)
1993
29
Cronkhite-Canada syndrome associated with peripheral neuropathy. (1659357)
1991
30
Cronkhite-Canada syndrome with hypothyroidism. (2373535)
1990
31
Cronkhite Canada syndrome: case report with some features not previously described. (2335285)
1990
32
A case with some components of Cronkhite-Canada syndrome in a family with Peutz-Jeghers syndrome. (3154191)
1988
33
Cronkhite-Canada syndrome: an analysis of clinical features and follow-up studies of 80 cases reported in Japan. (3077242)
1988
34
Colon cancer in the Cronkhite-Canada syndrome. (3745857)
1986
35
Erosive arthritis in Cronkhite-Canada syndrome. (4011892)
1985
36
The Cronkhite-Canada syndrome: an ultrastructural study of pathogenesis. (3973050)
1985
37
Cronkhite-Canada syndrome associated with a rectal cancer and adenomatous changes in colonic polyps. (3970299)
1985
38
Spontaneous improvement of Cronkhite-Canada syndrome in a postpartum female. (6714066)
1984
39
The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. (7109958)
1982
40
Cronkhite-Canada syndrome associated with systemic vasculitis: an autopsy study. (7106738)
1982
41
The radiographic appearance of the stomach in Cronkhite-Canada syndrome. (7291542)
1981
42
'Chronic atrophic gastroenterocolitis': a variant of Cronkhite-Canada syndrome? (6893407)
1980
43
Cronkhite-Canada syndrome: report of an unusual case. (7409393)
1980
44
Cronkhite-Canada syndrome in a Malay. (760669)
1979
45
Superficial cystic gastritis with alopecia. A forme fruste of the Cronkhite-Canada syndrome. (195553)
1977
46
An autopsy case of Cronkhite-Canada syndrome. (992257)
1976
47
The Cronkhite-Canada syndrome. (4635110)
1972
48
Radiological aspect of Cronkhite-Canada syndrome. (4664355)
1972
49
Gastrointestinal polyposis with protein-losing enteropathy, abnormal skin pigmentation and loss of hair and nails (Cronkhite-Canada syndrome). (5808657)
1969
50
Case of cronkhite--Canada syndrome with associated jejunal diverticulosis. (4964743)
1967

Genetic Variations for Cronkhite-Canada Syndrome

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Expression for genes affiliated with Cronkhite-Canada Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cronkhite-Canada Syndrome

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Pathways for genes affiliated with Cronkhite-Canada Syndrome

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53Reactome
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Pathways related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ALB, KRAS

Compounds for genes affiliated with Cronkhite-Canada Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1erlotinib44 49 1111.2ALB, KRAS
2irinotecan44 49 1111.2ALB, KRAS
3gefitinib44 49 1111.1ALB, KRAS
4fatty acid449.1ALB, KRAS
5imatinib44 49 1111.0KRAS, ALB
6vitamin d448.8ALB, KRAS

GO Terms for genes affiliated with Cronkhite-Canada Syndrome

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16Gene Ontology
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Biological processes related to Cronkhite-Canada Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1ALB, KRAS

Products for genes affiliated with Cronkhite-Canada Syndrome

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Cronkhite-Canada Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet