Aliases & Classifications for Croup

MalaCards integrated aliases for Croup:

Name: Croup 12 41 42 14 69
Laryngotracheobronchitis 12 69
Acute Laryngotracheobronchitis 12
Acute Obstructive Laryngitis 12
Croup Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9395
ICD10 33 J05.0
ICD9CM 35 464.4
MeSH 42 D003440
NCIt 47 C26735
UMLS 69 C0010380

Summaries for Croup

MedlinePlus : 41 croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). it causes difficulty breathing, a barking cough, and a hoarse voice. the cause is usually a virus, often parainfluenza virus. other causes include allergies and reflux. croup often starts out like a cold. but then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. there may also be a fever and high-pitched noisy sounds when breathing. the symptoms are usually worse at night, and last for about three to five days. children between the ages of 6 months and 3 years have the highest risk of getting croup. they may also have more severe symptoms. croup is more common in the fall and winter. most cases of viral croup are mild and can be treated at home. rarely, croup can become serious and interfere with your child's breathing. if you are worried about your child's breathing, call your health care provider right away.

MalaCards based summary : Croup, also known as laryngotracheobronchitis, is related to tracheitis and epiglottitis, and has symptoms including coughing, snoring and stridor. An important gene associated with Croup is CD14 (CD14 Molecule). The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include trachea, neutrophil and tongue, and related phenotype is Increased transferrin (TF) endocytosis.

Disease Ontology : 12 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

Wikipedia : 72 Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused... more...

Related Diseases for Croup

Diseases related to Croup via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
id Related Disease Score Top Affiliating Genes
1 tracheitis 11.2
2 epiglottitis 10.8
3 diphtheria 10.8
4 asthma 10.1
5 laryngitis 10.1
6 bronchiolitis 10.1
7 laryngotracheitis 10.1
8 pneumonia 10.0
9 bronchitis 9.9
10 influenza 9.9
11 atopy 9.9
12 pulmonary edema 9.9
13 gastroesophageal reflux 9.8
14 laryngomalacia 9.8
15 arthritis 9.8
16 esophagitis 9.8
17 myocarditis 9.8
18 herpes simplex 9.8
19 cystic fibrosis 9.6
20 otitis media 9.6
21 salmonellosis 9.6
22 chlamydia 9.6
23 toxic shock syndrome 9.6
24 candidiasis 9.6
25 pharyngitis 9.6
26 conjunctivitis 9.6
27 cleft lip 9.6
28 epididymo-orchitis 6.7 ATP6AP1 CD14 CLNK FOXD1 IYD MX2

Graphical network of the top 20 diseases related to Croup:



Diseases related to Croup

Symptoms & Phenotypes for Croup

UMLS symptoms related to Croup:


coughing, snoring, stridor, inspiratory stridor

GenomeRNAi Phenotypes related to Croup according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.1 ATP6AP1 CD14 CLNK FOXD1 MX2 ZFAT

Drugs & Therapeutics for Croup

Drugs for Croup (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2 Racepinephrine Approved Phase 4
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5 Adrenergic Agents Phase 4,Phase 3
6 Adrenergic Agonists Phase 4,Phase 3
7 Adrenergic alpha-Agonists Phase 4,Phase 3
8 Adrenergic beta-Agonists Phase 4
9 Anti-Asthmatic Agents Phase 4,Phase 3
10 Autonomic Agents Phase 4,Phase 3,Phase 2
11 Bronchodilator Agents Phase 4,Phase 3
12 Epinephryl borate Phase 4
13 Mydriatics Phase 4
14 Neurotransmitter Agents Phase 4,Phase 3
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
16 Respiratory System Agents Phase 4,Phase 3
17 Vasoconstrictor Agents Phase 4
18 Antiemetics Phase 4,Phase 2
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
20 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
21 BB 1101 Phase 4,Phase 2
22 Dexamethasone acetate Phase 4,Phase 2 1177-87-3
23 Gastrointestinal Agents Phase 4,Phase 2
24 glucocorticoids Phase 4,Phase 3,Phase 2
25 HIV Protease Inhibitors Phase 4,Phase 2
26 Hormone Antagonists Phase 4,Phase 3,Phase 2
27 Hormones Phase 4,Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
29
protease inhibitors Phase 4,Phase 2
30 Adrenergic beta-2 Receptor Agonists Phase 4
31 Anti-Allergic Agents Phase 4,Phase 3
32 Dermatologic Agents Phase 4,Phase 3
33
Fluticasone Phase 4,Phase 3 90566-53-3, 80474-14-2 62924 22833648
34 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
35
Salmeterol xinafoate Phase 4 94749-08-3 56801
36
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
37
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
38
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
39 Methylprednisolone acetate Phase 3,Phase 2
40 Methylprednisolone Hemisuccinate Phase 3,Phase 2
41 Prednisolone acetate Phase 3,Phase 2
42 Prednisolone hemisuccinate Phase 3,Phase 2
43 Prednisolone phosphate Phase 3,Phase 2
44 Adrenergic alpha-2 Receptor Agonists Phase 3
45 Analgesics Phase 3
46 Analgesics, Non-Narcotic Phase 3
47 Anesthetics Phase 3
48 Central Nervous System Depressants Phase 3
49 Hypnotics and Sedatives Phase 3
50 Pharmaceutical Solutions Phase 3,Phase 2

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Unknown status NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
2 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
3 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4 Salmeterol/fluticasone propionate and fluticasone propionate
4 Management of Recurrent Croup Completed NCT01748162 Phase 3 Fluticasone
5 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
6 Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy Recruiting NCT03211871 Phase 3 Dexmedetomidine;Normal Saline Flush, 0.9% Injectable Solution_#1
7 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
8 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
9 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Active, not recruiting NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
10 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
11 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
12 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Recruiting NCT02517294
13 Diagnosing Respiratory Disease in Children Using Cough Sounds Active, not recruiting NCT02973282
14 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240
15 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849

Search NIH Clinical Center for Croup

Cochrane evidence based reviews: croup

Genetic Tests for Croup

Anatomical Context for Croup

MalaCards organs/tissues related to Croup:

39
Trachea, Neutrophil, Tongue, Testes, Liver, Kidney

Publications for Croup

Articles related to Croup:

(show top 50) (show all 535)
id Title Authors Year
1
Effects of pre-education combined with a simulation for caring for children with croup on senior nursing students. ( 28436091 )
2017
2
A Narrowing Diagnosis: A Rare Cause of Adult Croup and Literature Review. ( 28163937 )
2017
3
Westley score and clinical factors in predicting the outcome of croup in the pediatric emergency department. ( 28556543 )
2017
4
Management of Croup in the Emergency Department: The Role of Multidose Nebulized Epinephrine. ( 28953096 )
2017
5
Mistaken Identity: Asthma and Croup in a Previously Healthy 9-Year-Old Male. ( 28777267 )
2017
6
Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study. ( 28398936 )
2017
7
Croup ( 28613724 )
2017
8
Association of croup with asthma in children: A cohort study. ( 28858086 )
2017
9
What is the effectiveness of systemic corticosteroids in children with croup? ( 28622285 )
2017
10
Variation in Inpatient Croup Management and Outcomes. ( 28292873 )
2017
11
Stridor is not always croup: infantile haemangioma in the airway. ( 28899875 )
2017
12
Intensive care management of children intubated for croup: a retrospective analysis. ( 27029657 )
2016
13
The role of larygotracheal reconstruction in the management of recurrent croup in patients with subglottic stenosis. ( 26857320 )
2016
14
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child. ( 26889375 )
2016
15
Recurrent croup and persistent laryngomalacia: Clinical resolution after supraglottoplasty. ( 27063760 )
2016
16
Croup. ( 27637124 )
2016
17
Delivery of Epinephrine in the Vapor Phase for the Treatment of Croup. ( 26910479 )
2016
18
Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada. ( 27514690 )
2016
19
Croup. ( 26776546 )
2016
20
Esophageal Foreign Body: A Case Report of a Refractory Croup in a 20-Month-Old Boy. ( 28008396 )
2016
21
Bronchoscopy findings in recurrent croup: A systematic review and meta-analysis. ( 27729160 )
2016
22
Telephone Out Patient Score: The Derivation and Validation of a Telephone Follow-up Assessment Tool for Use in Clinical Research in Children With Croup. ( 27139290 )
2016
23
Efficacy of nebulized L-epinephrine for treatment of croup: A randomized, double-blind study. ( 26463007 )
2015
24
About the Therapy of Laryngotracheitis (Croup): Significance of Rectal Dosage Forms. ( 26021412 )
2015
25
Steeple sign: a case of croup. ( 25929218 )
2015
26
Objective endoscopic findings in patients with recurrent croup: 10-year retrospective analysis. ( 26574171 )
2015
27
Inpatient Treatment after Multi-Dose Racemic Epinephrine for Croup in the Emergency Department. ( 26242923 )
2015
28
Stridor is not always croup. ( 25651384 )
2015
29
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015
30
Pediatric patients with chronic cough and recurrent croup: The case for a multidisciplinary approach. ( 25818348 )
2015
31
Evidence for Clinicians: Nebulized epinephrine for croup in children. ( 25722638 )
2015
32
Acute Respiratory Distress in Children: Croup and Acute Asthma : Guest Editor: Bhim S. Pandhi. ( 25257964 )
2014
33
Inpatient hospitalizations for croup. ( 24584978 )
2014
34
Role of Direct Laryngoscopy and Bronchoscopy in Recurrent Croup. ( 25389322 )
2014
35
Unexpected and severe postintubation croup after a very short day surgery in a pediatric patient: a case report. ( 25368790 )
2014
36
Croup. ( 25263284 )
2014
37
Role Of Operative Airway Evaluation In Children With Recurrent Croup: A Retrospective Cohort Study. ( 25409938 )
2014
38
Does Active Dissemination of Evidence Result in Faster Knowledge Transfer Than Passive Diffusion?: An Analysis of Trends of the Management of Pediatric Asthma and Croup in US Emergency Departments From 1995 to 2009. ( 24694945 )
2014
39
Accidental button battery ingestion presenting as croup. ( 24555666 )
2014
40
Weather factors associated with paediatric croup presentations to an Australian emergency department. ( 23558151 )
2014
41
Viral croup: diagnosis and a treatment algorithm. ( 24596395 )
2014
42
Laryngeal foreign body mimicking croup. ( 23348345 )
2013
43
Using ibuprofen to treat croup in six children presented to an emergency unit. ( 25268031 )
2013
44
CD14 gene variants and their importance for childhood croup, atopy, and asthma. ( 24347797 )
2013
45
A catastrophic presentation of adult croup. ( 23767911 )
2013
46
Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years. ( 23694832 )
2013
47
Multilevel airway obstruction including rare tongue base mass presenting as severe croup in an infant. ( 22995201 )
2013
48
Nebulized epinephrine for croup in children. ( 24114291 )
2013
49
Impacted button-battery masquerading as croup. ( 23375223 )
2013
50
Heliox for croup in children. ( 24318607 )
2013

Variations for Croup

Expression for Croup

Search GEO for disease gene expression data for Croup.

Pathways for Croup

GO Terms for Croup

Sources for Croup

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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