CROUP
MCID: CRP002
MIFTS: 38

Croup (CROUP) malady

Respiratory diseases category

Summaries for Croup

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. the disease is caused by viruses, bacteria, allergies and inhaled irritants. it is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. croup is caused by parainfluenza virus (types 1 and 2), influenza a and b viruses, measles virus, adenovirus, respiratory syncytial virus, staphylococcus and streptococcus.

MalaCards: Croup, also known as laryngotracheobronchitis, is related to epiglottitis and laryngitis. An important gene associated with Croup is IYD (iodotyrosine deiodinase). Affiliated tissues include trachea, tongue and kidney.

Wikipedia:66 Croup (or laryngotracheobronchitis) is a respiratory condition that is usually triggered by an acute... more...

Aliases & Classifications for Croup

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

croup 9 11 63
laryngotracheobronchitis 9 63
acute laryngotracheobronchitis 9
acute obstructive laryngitis 9
croup syndrome 9


External Ids:

Disease Ontology9 DOID:9395
ICD9CM28 464.4
MeSH36 D003440
NCIt41 C26735
ICD1026 J05.0

Related Diseases for Croup

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Croup via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1epiglottitis10.7
2laryngitis10.5
3blindness10.5
4tracheitis10.5
5bronchiolitis10.4
6laryngotracheitis10.4
7asthma10.4
8bronchitis10.3
9influenza10.3
10pneumonia10.3
11pulmonary edema10.2
12atopy10.2
13arthritis10.1
14herpes simplex10.1
15myocarditis10.1
16pulmonary function10.1
17peripheral t-cell lymphoma10.0
18cystic fibrosis10.0
19pharyngitis10.0
20cleft lip10.0
21gastroesophageal reflux disease10.0
22toxic shock syndrome10.0
23candidiasis10.0
24conjunctivitis10.0
25esophagitis10.0
26otitis media10.0
27laryngomalacia10.0

Graphical network of the top 20 diseases related to Croup:



Diseases related to croup

Symptoms for Croup

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Drugs & Therapeutics for Croup

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Croup

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Anatomical Context for Croup

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Sources:
34MalaCards
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MalaCards organs/tissues related to Croup:

34
Trachea, Tongue, Kidney, Testes

Animal Models for Croup or affiliated genes

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Publications for Croup

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Sources:
53PubMed
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Articles related to Croup:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
A catastrophic presentation of adult croup. (23767911)
2013
2
Variation and trends in ED use of radiographs for asthma, bronchiolitis, and croup in children. (23878045)
2013
3
Heliox for croup in children. (24318607)
2013
4
The management of recurrent croup in children. (23544702)
2013
5
Fifteen-minute consultation: structured approach to management of a child with recurrent croup. (24231112)
2013
6
Atypical croup: association with airway lesions, atopy, and esophagitis. (22588730)
2012
7
Evidence to support current use of nebulised epinephrine in croup to achieve immediate clinical improvement. (22417464)
2012
8
The administration of general anesthesia to a patient with croup. (22435283)
2011
9
Treatment of viral croup. No humidity needed. (21319449)
2010
10
Cricoarytenoid arthritis presenting as croup. (19875539)
2009
11
A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup. (17208307)
2007
12
Humidified air for croup? (17225704)
2007
13
Recurrent croup presentation, diagnosis, and management. (17980773)
2007
14
100% humidity no better than blow-by for croup. (16795940)
2006
15
Delivery of 100%, 40%, and blow-by humidity did not differ for change in croup scores in children with moderate croup. (17076007)
2006
16
Croup. (16620410)
2005
17
Managing children with croup in emergency departments. (16259236)
2005
18
State of the evidence for standard-of-care treatments for croup: are we where we need to be? (16378046)
2005
19
Croup--the bark is worse than the bite. (15385654)
2004
20
Oral dexamethasone for mild croup. (15619743)
2004
21
Oral dexamethasone for mild croup. (15619742)
2004
22
Viral croup. (14971835)
2004
23
Croup. (12603886)
2002
24
Management of croup. (11960512)
2002
25
An update on inflammatory disorders of the pediatric airway: epiglottitis, croup, and tracheitis. (11464324)
2001
26
Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing. (11099587)
2000
27
Randomized controlled trial of dexamethasone in infectious croup. (9175396)
1997
28
The role of corticosteroids in bronchiolitis and croup. (9246128)
1997
29
Efficacy of oral dexamethasone for outpatient croup. (8917136)
1996
30
Croup and related disorders. (8498980)
1993
31
Herpes simplex virus infection. A rare cause of prolonged croup. (8387316)
1993
32
Recurrent and non-recurrent croup: an epidemiological study. (3266553)
1988
33
Use of steroids and a long-acting vasoconstrictor in the treatment of postintubation croup. A ferret model. (3620146)
1987
34
Diagnostic and therapeutic efficiency in croup and epiglottitis. (3573912)
1987
35
Defective regulation of immune responses in croup due to parainfluenza virus. (2991841)
1985
36
Croup (laryngotracheobronchitis) and epiglottitis (supraglottitis): when is tracheostomy necessary? (6592397)
1984
37
Assessment of intubation in croup and epiglottitis. (7114722)
1982
38
Croup. (7148634)
1982
39
Wheezing in infancy, croup, and epiglottitis. (7060393)
1982
40
Steroid treatment of pseudo-croup. (7161115)
1982
41
Definition of croup. (7373480)
1980
42
Efficacy of helium--oxygen mixtures in the management of severe viral and post-intubation croup. (466564)
1979
43
Letter: Racemic epinephrine in croup. (4590735)
1974
44
The evaluation of racemic epinephrine in the treatment of infectious croup. (4579587)
1973
45
The diagnosis of epiglottitis: simplicity and reliability of radiographs of the neck in the differential diagnosis of the croup syndrome. (5016357)
1972
46
Corticosteroids in croup: further testimony. (5013433)
1972
47
Croup 1967-1969: survey from Wellington Hospital. (5289741)
1971
48
Environmental factors in Croup syndrome. (5127306)
1971
49
Weight and sex of children hospitalized with infectious croup. An analysis of 850 cases. (13970618)
1963
50
Acute obstructive laryngitis. (croup). (13262654)
1955

Variations for Croup

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Expression for genes affiliated with Croup

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Croup

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Pathways for genes affiliated with Croup

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Compounds for genes affiliated with Croup

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GO Terms for genes affiliated with Croup

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17Gene Ontology
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Cellular components related to Croup according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.7MX2, NCAPG, LCORL, ZNF83, ZNF17, FOXD2

Molecular functions related to Croup according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA bindingGO:0036778.3LCORL, ZNF83, ZNF17, ZFAT

Products for genes affiliated with Croup

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Sources for Croup

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet