Aliases & Classifications for Croup

MalaCards integrated aliases for Croup:

Name: Croup 12 72 40 41 14 69
Laryngotracheobronchitis 12 69
Acute Laryngotracheobronchitis 12
Acute Obstructive Laryngitis 12
Croup Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9395
ICD10 32 J05.0
ICD9CM 34 464.4
MeSH 41 D003440
NCIt 46 C26735

Summaries for Croup

MedlinePlus : 40 Croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). It causes difficulty breathing, a barking cough, and a hoarse voice. The cause is usually a virus, often parainfluenza virus. Other causes include allergies and reflux. Croup often starts out like a cold. But then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. There may also be a fever and high-pitched noisy sounds when breathing. The symptoms are usually worse at night, and last for about three to five days. Children between the ages of 6 months and 3 years have the highest risk of getting croup. They may also have more severe symptoms. Croup is more common in the fall and winter. Most cases of viral croup are mild and can be treated at home. Rarely, croup can become serious and interfere with your child's breathing. If you are worried about your child's breathing, call your health care provider right away.

MalaCards based summary : Croup, also known as laryngotracheobronchitis, is related to tracheitis and diphtheria, and has symptoms including inspiratory stridor, stridor and snoring. An important gene associated with Croup is CD14 (CD14 Molecule), and among its related pathways/superpathways is Phagosome. The drugs Dexamethasone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include trachea, neutrophil and tongue.

Disease Ontology : 12 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

Wikipedia : 72 Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused... more...

Related Diseases for Croup

Diseases related to Croup via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 tracheitis 11.3
2 diphtheria 10.9
3 epiglottitis 10.9
4 asthma 10.2
5 laryngitis 10.2
6 bronchiolitis 10.2
7 laryngotracheitis 10.2
8 pneumonia 10.1
9 bronchitis 10.0
10 influenza 10.0
11 ige responsiveness, atopic 9.9
12 aging 9.9
13 mungan syndrome 9.9
14 hydrops, lactic acidosis, and sideroblastic anemia 9.9
15 pulmonary edema 9.9
16 gastroesophageal reflux 9.9
17 laryngomalacia 9.9
18 arthritis 9.9
19 esophagitis 9.9
20 myocarditis 9.9
21 herpes simplex 9.9
22 fibrosis of extraocular muscles, congenital, 1 9.7
23 otitis media 9.7
24 cystic fibrosis 9.7
25 pulmonary disease, chronic obstructive 9.7
26 autoimmune lymphoproliferative syndrome, type v 9.7
27 salmonellosis 9.7
28 chlamydia 9.7
29 toxic shock syndrome 9.7
30 candidiasis 9.7
31 pharyngitis 9.7
32 conjunctivitis 9.7
33 cleft lip 9.7

Graphical network of the top 20 diseases related to Croup:



Diseases related to Croup

Symptoms & Phenotypes for Croup

UMLS symptoms related to Croup:


inspiratory stridor, stridor, snoring, coughing

Drugs & Therapeutics for Croup

Drugs for Croup (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4 Racepinephrine Approved Phase 4 329-65-7
5
Salmeterol xinafoate Phase 4 94749-08-3 56801
6 Dexamethasone acetate Phase 4,Phase 2 1177-87-3
7
Fluticasone Phase 4,Phase 3 80474-14-2, 90566-53-3 22833648 62924
8 glucocorticoids Phase 4,Phase 3,Phase 2
9
protease inhibitors Phase 4,Phase 2
10 Respiratory System Agents Phase 4,Phase 3
11 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
12 Adrenergic Agents Phase 4,Phase 3
13 Adrenergic Agonists Phase 4,Phase 3
14 Adrenergic beta-2 Receptor Agonists Phase 4
15 Adrenergic beta-Agonists Phase 4
16 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
17 Neurotransmitter Agents Phase 4,Phase 3
18 HIV Protease Inhibitors Phase 4,Phase 2
19 Hormone Antagonists Phase 4,Phase 3,Phase 2
20 Dermatologic Agents Phase 4,Phase 3
21 Hormones Phase 4,Phase 3,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
23 Anti-Allergic Agents Phase 4,Phase 3
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
25 Anti-Asthmatic Agents Phase 4,Phase 3
26 Antiemetics Phase 4,Phase 3,Phase 2
27 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
29 BB 1101 Phase 4,Phase 2
30 Autonomic Agents Phase 4,Phase 3,Phase 2
31 Bronchodilator Agents Phase 4,Phase 3
32 Adrenergic alpha-Agonists Phase 4,Phase 3
33 Mydriatics Phase 4
34 Vasoconstrictor Agents Phase 4
35 Epinephryl borate Phase 4
36
Dexmedetomidine Approved, Vet_approved Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
37
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
38
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
39 Analgesics Phase 3
40 Central Nervous System Depressants Phase 3
41 Adrenergic alpha-2 Receptor Agonists Phase 3
42 Analgesics, Non-Narcotic Phase 3
43 Anesthetics Phase 3
44 Hypnotics and Sedatives Phase 3
45 Pharmaceutical Solutions Phase 3,Phase 2
46 Prednisolone acetate Phase 3,Phase 2
47 Methylprednisolone acetate Phase 3,Phase 2
48 Methylprednisolone Hemisuccinate Phase 3,Phase 2
49 Neuroprotective Agents Phase 3,Phase 2
50 Prednisolone hemisuccinate Phase 3,Phase 2

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Community Care for Croup (RCT) Completed NCT01042145 Phase 4 Prednisone;Dexamethasone
2 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4 Salmeterol/fluticasone propionate and fluticasone propionate
3 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Recruiting NCT01664507 Phase 4 conventional dose epinephrine;low dose epinephrine
4 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
5 Dexmedetomidine Infusion as an Analgesic Adjuvant During Laparoscopic Cholecystectomy Recruiting NCT03211871 Phase 3 Dexmedetomidine;Normal Saline Flush, 0.9% Injectable Solution_#1
6 Management of Recurrent Croup Terminated NCT01748162 Phase 3 Fluticasone;Prednisolone IF needed
7 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3 beclomethasone dipropionate suspension for nebulisation 800 mcg/2 ml;Placebo solution for nebulisation 2 ml
8 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
9 Steroids In The Management Of Acute Asthma Exacerbations In Children, Which Form Is More Suitable? Active, not recruiting NCT03204760 Phase 2 Dexamethasone 8Mg Solution for Injection;Prednisolone Oral, Per 5 Mg
10 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
11 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
12 Diagnosing Respiratory Disease in Children Using Cough Sounds Completed NCT02973282
13 Diagnosing Respiratory Disease in Children Using Cough Sounds 2 Recruiting NCT03392363
14 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Recruiting NCT02517294
15 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240
16 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849

Search NIH Clinical Center for Croup

Cochrane evidence based reviews: croup

Genetic Tests for Croup

Anatomical Context for Croup

MalaCards organs/tissues related to Croup:

38
Trachea, Neutrophil, Tongue, Testes, Liver, Kidney

Publications for Croup

Articles related to Croup:

(show top 50) (show all 543)
# Title Authors Year
1
Prenatal phthalate exposure was associated with croup in Swedish infants. ( 29385277 )
2018
2
Prognostic factors and importance of recognition of adult croup. ( 29310492 )
2018
3
Cough sound analysis for diagnosing croup in pediatric patients using biologically inspired features. ( 29060916 )
2017
4
Association of croup with asthma in children: A cohort study. ( 28858086 )
2017
5
Failure of Outpatient Management With Different Observation Times After Racemic Epinephrine for Croup. ( 29034735 )
2017
6
A Narrowing Diagnosis: A Rare Cause of Adult Croup and Literature Review. ( 28163937 )
2017
7
Effects of pre-education combined with a simulation for caring for children with croup on senior nursing students. ( 28436091 )
2017
8
Mistaken Identity: Asthma and Croup in a Previously Healthy 9-Year-Old Male. ( 28777267 )
2017
9
Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study. ( 28398936 )
2017
10
Calculated decisions: Westley croup score ( 29115814 )
2017
11
Management of Croup in the Emergency Department: The Role of Multidose Nebulized Epinephrine. ( 28953096 )
2017
12
Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup. ( 29100262 )
2017
13
Croup ( 28613724 )
2017
14
Are cytokines and cortisol important predictors for the severity of pediatric croup: A case control study. ( 29376573 )
2017
15
Westley score and clinical factors in predicting the outcome of croup in the pediatric emergency department. ( 28556543 )
2017
16
What is the effectiveness of systemic corticosteroids in children with croup? ( 28622285 )
2017
17
Stridor is not always croup: infantile haemangioma in the airway. ( 28899875 )
2017
18
A Systematic Review and Comprehensive Critical Analysis Examining the Use of Prednisolone for the Treatment of Mild to Moderate Croup. ( 29290883 )
2017
19
Variation in Inpatient Croup Management and Outcomes. ( 28292873 )
2017
20
Telephone Out Patient Score: The Derivation and Validation of a Telephone Follow-up Assessment Tool for Use in Clinical Research in Children With Croup. ( 27139290 )
2016
21
Recurrent croup and persistent laryngomalacia: Clinical resolution after supraglottoplasty. ( 27063760 )
2016
22
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child. ( 26889375 )
2016
23
Esophageal Foreign Body: A Case Report of a Refractory Croup in a 20-Month-Old Boy. ( 28008396 )
2016
24
Intensive care management of children intubated for croup: a retrospective analysis. ( 27029657 )
2016
25
Croup. ( 27637124 )
2016
26
Delivery of Epinephrine in the Vapor Phase for the Treatment of Croup. ( 26910479 )
2016
27
Croup. ( 26776546 )
2016
28
Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada. ( 27514690 )
2016
29
Bronchoscopy findings in recurrent croup: A systematic review and meta-analysis. ( 27729160 )
2016
30
The role of larygotracheal reconstruction in the management of recurrent croup in patients with subglottic stenosis. ( 26857320 )
2016
31
About the Therapy of Laryngotracheitis (Croup): Significance of Rectal Dosage Forms. ( 26021412 )
2015
32
Stridor is not always croup. ( 25651384 )
2015
33
Pediatric patients with chronic cough and recurrent croup: The case for a multidisciplinary approach. ( 25818348 )
2015
34
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015
35
Efficacy of nebulized L-epinephrine for treatment of croup: A randomized, double-blind study. ( 26463007 )
2015
36
Objective endoscopic findings in patients with recurrent croup: 10-year retrospective analysis. ( 26574171 )
2015
37
Evidence for Clinicians: Nebulized epinephrine for croup in children. ( 25722638 )
2015
38
Steeple sign: a case of croup. ( 25929218 )
2015
39
Inpatient Treatment after Multi-Dose Racemic Epinephrine for Croup in the Emergency Department. ( 26242923 )
2015
40
Acute Respiratory Distress in Children: Croup and Acute Asthma : Guest Editor: Bhim S. Pandhi. ( 25257964 )
2014
41
Unexpected and severe postintubation croup after a very short day surgery in a pediatric patient: a case report. ( 25368790 )
2014
42
Viral croup: diagnosis and a treatment algorithm. ( 24596395 )
2014
43
Role Of Operative Airway Evaluation In Children With Recurrent Croup: A Retrospective Cohort Study. ( 25409938 )
2014
44
Does Active Dissemination of Evidence Result in Faster Knowledge Transfer Than Passive Diffusion?: An Analysis of Trends of the Management of Pediatric Asthma and Croup in US Emergency Departments From 1995 to 2009. ( 24694945 )
2014
45
Inpatient hospitalizations for croup. ( 24584978 )
2014
46
Accidental button battery ingestion presenting as croup. ( 24555666 )
2014
47
Role of Direct Laryngoscopy and Bronchoscopy in Recurrent Croup. ( 25389322 )
2014
48
Weather factors associated with paediatric croup presentations to an Australian emergency department. ( 23558151 )
2014
49
Croup. ( 25263284 )
2014
50
Laryngomalacia presenting as recurrent croup in an infant. ( 23424697 )
2013

Variations for Croup

Expression for Croup

Search GEO for disease gene expression data for Croup.

Pathways for Croup

Pathways related to Croup according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 ATP6AP1 CD14

GO Terms for Croup

Molecular functions related to Croup according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.62 ATP6AP1 RIMS2

Sources for Croup

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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