CROUP
MCID: CRP002
MIFTS: 37

Croup (CROUP) malady

Categories: Respiratory diseases

Aliases & Classifications for Croup

Aliases & Descriptions for Croup:

Name: Croup 12 41 42 14 69
Laryngotracheobronchitis 12 69
Acute Laryngotracheobronchitis 12
Acute Obstructive Laryngitis 12
Croup Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9395
ICD10 33 J05.0
ICD9CM 35 464.4
MeSH 42 D003440
NCIt 47 C26735
UMLS 69 C0010380

Summaries for Croup

MedlinePlus : 41 croup is an inflammation of the vocal cords (larynx) and windpipe (trachea). it causes difficulty breathing, a barking cough, and a hoarse voice. the cause is usually a virus, often parainfluenza virus. other causes include allergies and reflux. croup often starts out like a cold. but then the vocal cords and windpipe become swollen, causing the hoarseness and the cough. there may also be a fever and high-pitched noisy sounds when breathing. the symptoms are usually worse at night, and last for about three to five days. children between the ages of 6 months and 3 years have the highest risk of getting croup. they may also have more severe symptoms. croup is more common in the fall and winter. most cases of viral croup are mild and can be treated at home. rarely, croup can become serious and interfere with your child's breathing. if you are worried about your child's breathing, call your health care provider right away.

MalaCards based summary : Croup, also known as laryngotracheobronchitis, is related to tracheitis and epiglottitis, and has symptoms including coughing, snoring and stridor. An important gene associated with Croup is CD14 (CD14 Molecule). The drugs Epinephrine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include trachea, testes and neutrophil.

Disease Ontology : 12 A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

Wikipedia : 71 Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused... more...

Related Diseases for Croup

Diseases related to Croup via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
id Related Disease Score Top Affiliating Genes
1 tracheitis 11.2
2 epiglottitis 10.8
3 diphtheria 10.8
4 laryngitis 10.1
5 bronchiolitis 10.1
6 asthma 10.1
7 laryngotracheitis 10.1
8 pneumonia 10.0
9 bronchitis 9.9
10 influenza 9.9
11 atopy 9.8
12 pulmonary edema 9.8
13 gastroesophageal reflux 9.8
14 laryngomalacia 9.8
15 arthritis 9.8
16 esophagitis 9.8
17 myocarditis 9.8
18 herpes simplex 9.8
19 cystic fibrosis 9.6
20 otitis media 9.6
21 salmonellosis 9.6
22 chlamydia 9.6
23 toxic shock syndrome 9.6
24 candidiasis 9.6
25 pharyngitis 9.6
26 conjunctivitis 9.6
27 cleft lip 9.6
28 hypertensive encephalopathy 8.8 ATP6AP1 CD14 CLCN2 CLNK FOXD1 IYD

Graphical network of the top 20 diseases related to Croup:



Diseases related to Croup

Symptoms & Phenotypes for Croup

UMLS symptoms related to Croup:


coughing, snoring, stridor, inspiratory stridor

Drugs & Therapeutics for Croup

Drugs for Croup (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-Agonists Phase 4
7 Adrenergic beta-Agonists Phase 4
8 Anti-Asthmatic Agents Phase 4,Phase 3
9 Autonomic Agents Phase 4,Phase 3
10 Bronchodilator Agents Phase 4,Phase 3
11 Epinephryl borate Phase 4
12 Mydriatics Phase 4
13 Neurotransmitter Agents Phase 4
14 Peripheral Nervous System Agents Phase 4,Phase 3
15 Racepinephrine Phase 4
16 Respiratory System Agents Phase 4,Phase 3
17 Vasoconstrictor Agents Phase 4
18 Antiemetics Phase 4
19 Anti-Inflammatory Agents Phase 4,Phase 3
20 Antineoplastic Agents, Hormonal Phase 4,Phase 3
21 BB 1101 Phase 4
22 Dexamethasone 21-phosphate Phase 4
23 Dexamethasone acetate Phase 4 1177-87-3
24 Gastrointestinal Agents Phase 4
25 glucocorticoids Phase 4,Phase 3
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4,Phase 3
28 Hormones Phase 4,Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
30
protease inhibitors Phase 4
31 Adrenergic beta-2 Receptor Agonists Phase 4
32 Anti-Allergic Agents Phase 4,Phase 3
33 Dermatologic Agents Phase 4,Phase 3
34
Fluticasone Phase 4,Phase 3 90566-53-3, 80474-14-2 62924 22833648
35 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
36
Salmeterol xinafoate Phase 4 94749-08-3 56801
37
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
38
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
39 Methylprednisolone acetate Phase 3
40 Methylprednisolone Hemisuccinate Phase 3
41 Prednisolone acetate Phase 3
42 Prednisolone hemisuccinate Phase 3
43 Prednisolone phosphate Phase 3
44
Beclomethasone Phase 3 4419-39-0 20469
45 Pharmaceutical Solutions Phase 3
46 Vaccines Phase 1

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 The Effect and Safety of Low Dose Nebulized Epinephrine in Croup Unknown status NCT01664507 Phase 4
2 Community Care for Croup (RCT) Completed NCT01042145 Phase 4
3 Study Of Airway Physiology In Adults. SERETIDE DISKUS® Inhaler and FLIXOTIDE® Inhaler Are Trademarks of GSK Croup of Companies. Completed NCT00370591 Phase 4
4 Management of Recurrent Croup Completed NCT01748162 Phase 3
5 A Trial of Point of Care Information in Ambulatory Pediatrics Completed NCT00368823 Phase 3
6 Efficacy of Nebulized Beclomethasone Dipropionate (BDP) in the Treatment of Moderate Croup Terminated NCT00938353 Phase 3
7 Comparing Different Ways of Delivering Humidity to Children With Croup Completed NCT00230841 Phase 2
8 Safety of and Immune Response to Recombinant Live-Attenuated Parainfluenza Type 1 Virus Vaccine Completed NCT00641017 Phase 1
9 A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers Recruiting NCT00186927 Phase 1
10 Diagnosing Respiratory Disease in Children Using Cough Sounds Recruiting NCT02973282
11 , "Mucosal Injury During Nasotracheal Intubation for Dental Procedures in Children-does the Tube Design Matter?" Recruiting NCT02517294
12 Sunface Mirroring RCT in Brazil Not yet recruiting NCT03178240
13 A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup Terminated NCT00147849

Search NIH Clinical Center for Croup

Cochrane evidence based reviews: croup

Genetic Tests for Croup

Anatomical Context for Croup

MalaCards organs/tissues related to Croup:

39
Trachea, Testes, Neutrophil, Liver, Kidney, Tongue

Publications for Croup

Articles related to Croup:

(show top 50) (show all 524)
id Title Authors Year
1
Intensive care management of children intubated for croup: a retrospective analysis. ( 27029657 )
2016
2
Croup. ( 26776546 )
2016
3
Esophageal Foreign Body: A Case Report of a Refractory Croup in a 20-Month-Old Boy. ( 28008396 )
2016
4
Telephone Out Patient Score: The Derivation and Validation of a Telephone Follow-up Assessment Tool for Use in Clinical Research in Children With Croup. ( 27139290 )
2016
5
Bronchoscopy findings in recurrent croup: A systematic review and meta-analysis. ( 27729160 )
2016
6
The role of larygotracheal reconstruction in the management of recurrent croup in patients with subglottic stenosis. ( 26857320 )
2016
7
Recurrent croup and persistent laryngomalacia: Clinical resolution after supraglottoplasty. ( 27063760 )
2016
8
Croup. ( 27637124 )
2016
9
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child. ( 26889375 )
2016
10
Use of laboratory and administrative data to understand the potential impact of human parainfluenza virus 4 on cases of bronchiolitis, croup, and pneumonia in Alberta, Canada. ( 27514690 )
2016
11
Delivery of Epinephrine in the Vapor Phase for the Treatment of Croup. ( 26910479 )
2016
12
Objective endoscopic findings in patients with recurrent croup: 10-year retrospective analysis. ( 26574171 )
2015
13
Stridor is not always croup. ( 25651384 )
2015
14
Clinical characteristics of children and adolescents with croup and epiglottitis who visited 146 Emergency Departments in Korea. ( 26576182 )
2015
15
About the Therapy of Laryngotracheitis (Croup): Significance of Rectal Dosage Forms. ( 26021412 )
2015
16
Steeple sign: a case of croup. ( 25929218 )
2015
17
Inpatient Treatment after Multi-Dose Racemic Epinephrine for Croup in the Emergency Department. ( 26242923 )
2015
18
Evidence for Clinicians: Nebulized epinephrine for croup in children. ( 25722638 )
2015
19
Pediatric patients with chronic cough and recurrent croup: The case for a multidisciplinary approach. ( 25818348 )
2015
20
Efficacy of nebulized L-epinephrine for treatment of croup: A randomized, double-blind study. ( 26463007 )
2015
21
Acute Respiratory Distress in Children: Croup and Acute Asthma : Guest Editor: Bhim S. Pandhi. ( 25257964 )
2014
22
Weather factors associated with paediatric croup presentations to an Australian emergency department. ( 23558151 )
2014
23
Accidental button battery ingestion presenting as croup. ( 24555666 )
2014
24
Role of Direct Laryngoscopy and Bronchoscopy in Recurrent Croup. ( 25389322 )
2014
25
Viral croup: diagnosis and a treatment algorithm. ( 24596395 )
2014
26
Does Active Dissemination of Evidence Result in Faster Knowledge Transfer Than Passive Diffusion?: An Analysis of Trends of the Management of Pediatric Asthma and Croup in US Emergency Departments From 1995 to 2009. ( 24694945 )
2014
27
Unexpected and severe postintubation croup after a very short day surgery in a pediatric patient: a case report. ( 25368790 )
2014
28
Role Of Operative Airway Evaluation In Children With Recurrent Croup: A Retrospective Cohort Study. ( 25409938 )
2014
29
Inpatient hospitalizations for croup. ( 24584978 )
2014
30
Croup. ( 25263284 )
2014
31
Variation and trends in ED use of radiographs for asthma, bronchiolitis, and croup in children. ( 23878045 )
2013
32
Nebulized epinephrine for croup in children. ( 24114291 )
2013
33
Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during 4 consecutive years. ( 23694832 )
2013
34
Croup in children. ( 23939212 )
2013
35
Using ibuprofen to treat croup in six children presenting to an emergency unit. ( 23964610 )
2013
36
The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. ( 24092872 )
2013
37
Using ibuprofen to treat croup in six children presented to an emergency unit. ( 25268031 )
2013
38
Impacted button-battery masquerading as croup. ( 23375223 )
2013
39
Laryngeal foreign body mimicking croup. ( 23348345 )
2013
40
Heliox for croup in children. ( 24318607 )
2013
41
A catastrophic presentation of adult croup. ( 23767911 )
2013
42
Multilevel airway obstruction including rare tongue base mass presenting as severe croup in an infant. ( 22995201 )
2013
43
CD14 gene variants and their importance for childhood croup, atopy, and asthma. ( 24347797 )
2013
44
Laryngomalacia presenting as recurrent croup in an infant. ( 23424697 )
2013
45
The management of recurrent croup in children. ( 23544702 )
2013
46
Fifteen-minute consultation: structured approach to management of a child with recurrent croup. ( 24231112 )
2013
47
How fast does oral dexamethasone work in mild to moderately severe croup? A randomized double-blinded clinical trial. ( 22313564 )
2012
48
Heliox in children with croup: a strategy to hasten improvement. ( 22541348 )
2012
49
Images in clinical medicine. Steeple sign of croup. ( 22762320 )
2012
50
Evidence to support current use of nebulised epinephrine in croup to achieve immediate clinical improvement. ( 22417464 )
2012

Variations for Croup

Expression for Croup

Search GEO for disease gene expression data for Croup.

Pathways for Croup

GO Terms for Croup

Sources for Croup

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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