MCID: CRZ001
MIFTS: 67

Crouzon Syndrome malady

Genetic diseases, Rare diseases, Eye diseases, Bone diseases, Fetal diseases categories

Aliases & Classifications for Crouzon Syndrome

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Aliases & Descriptions for Crouzon Syndrome:

Name: Crouzon Syndrome 49 32 10 11 68 45 23 47 12 67
Crouzon Craniofacial Dysostosis 45 22 23 51 67
Craniofacial Dysostosis 10 68 23 36
Craniofacial Dysostosis Type 1 45 22 65
Crouzon Disease 45 22 51
Craniofacial Dysarthrosis 68 23
Crouzons Disease 23 24
 
Cfd1 45 67
Craniofacial Dysostosis, Type 1; Cfd1 23
Craniofacial Dysostosis Syndrome 23
Craniofacial Dysostosis Type I 67
Crouzon's Disease 23
Cs 67


Classifications:



Characteristics (Orphanet epidemiological data):

51
crouzon craniofacial dysostosis:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy


External Ids:

OMIM49 123500
Disease Ontology10 DOID:2339
MeSH36 D003394
NCIt42 C84653
SNOMED-CT59 28861008
Orphanet51 207
ICD10 via Orphanet28 Q75.1
ICD1027 Q75.1

Summaries for Crouzon Syndrome

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NIH Rare Diseases:45 Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). this early fusion prevents the skull from growing normally and affects the shape of the head and face. the abnormal growth of the bones in the skull causes wide-set, bulging eyes, eyes that do not point in the same direction (strabismus), a beaked nose, and an underdeveloped upper jaw. other features may include dental problems, hearing loss, and an opening in the lip and the roof of the mouth (cleft lip and palate). the severity of these signs and symptoms varies among affected people. people with crouzon syndrome are usually of normal intelligence. crouzon syndrome is caused by mutations in the fgfr2 gene and is inherited in an autosomal dominant fashion. last updated: 3/24/2011

MalaCards based summary: Crouzon Syndrome, also known as crouzon craniofacial dysostosis, is related to achondroplasia and pfeiffer syndrome, and has symptoms including high forehead, craniosynostosis and abnormal facial shape. An important gene associated with Crouzon Syndrome is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways are Central carbon metabolism in cancer and Akt Signaling Pathway. Affiliated tissues include bone, eye and skin, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Disease Ontology:10 A craniosynostosis that involves premature fusion of certain skull bones. this early fusion prevents the skull from growing normally and affects the shape of the head and face. the disease is associated with mutations in the fgfr2 gene.

Genetics Home Reference:23 Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face.

OMIM:49 Crouzon syndrome is an autosomal dominant disorder characterized by craniosynostosis causing secondary alterations of... (123500) more...

UniProtKB/Swiss-Prot:67 Crouzon syndrome: An autosomal dominant syndrome characterized by craniosynostosis, hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism.

Wikipedia:68 Crouzon syndrome is an autosomal dominant genetic disorder known as a branchial arch syndrome.... more...

Related Diseases for Crouzon Syndrome

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Diseases related to Crouzon Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1achondroplasia30.5FGFR1, FGFR2, FGFR3
2pfeiffer syndrome30.5FGFR1, FGFR2, FGFR3
3apert syndrome30.5FGF2, FGFR1, FGFR2, FGFR3
4jackson-weiss syndrome30.3FGFR1, FGFR2, FGFR3
5saethre-chotzen syndrome30.0FGFR1, FGFR2, FGFR3, MSX2
6crouzon syndrome with acanthosis nigricans10.8
7acanthosis nigricans10.7
8craniofacial dysostosis with diaphyseal hyperplasia10.5
9craniosynostosis10.5
10malaria10.4
11craniofacial dysostosis arthrogryposis progeroid appearence10.4
12gorlin chaudhry moss syndrome10.4
13cockayne syndrome, type a10.4
14parasitic protozoa infectious disease10.3
15dysostosis10.3
16cockayne syndrome10.3
17potocki-shaffer syndrome10.3
18hypertrichosis10.3
19von economo's disease10.2FGFR2, FGFR3
20beare-stevenson cutis gyrata syndrome10.2FGFR2, FGFR3
21obstructive sleep apnea10.2
22sleep apnea10.2
23strabismus10.2
24synostosis10.2
25meningoencephalocele10.2
26pfeiffer syndrome type 1, 2 and 310.2FGFR1, FGFR2
27barbiturate abuse10.2FGFR2, FGFR3
28congestive heart failure10.2
29cushing's syndrome10.2
30plasmodium falciparum malaria10.2
31congenital heart disease10.2
32larynx sarcoma10.2FGF2, TGFB1
33spinocerebellar ataxia 510.2FGFR1, FGFR2
34branchiootorenal syndrome10.2FGF2, TGFB1
35cowden syndrome 110.1
36periodic fever, familial10.1
37xeroderma pigmentosum, group d10.1
38vaccinia10.1
39tumor necrosis factor receptor 1 associated periodic syndrome10.1
40flna-related periventricular nodular heterotopia10.1FGFR1, FGFR2, FGFR3
41plagiocephaly and x-linked mental retardation10.1FGFR1, FGFR2, FGFR3
42osteoglophonic dysplasia10.1FGFR1, FGFR2, FGFR3
43muenke syndrome10.1FGFR1, FGFR2, FGFR3
44gonococcal iridocyclitis10.1FGFR2, FGFR3, TGFB1
45patent ductus arteriosus10.1
46omphalocele10.1
47acrofrontofacionasal dysostosis10.1
48intracranial hypertension10.1
49metaphyseal dysplasia10.1
50craniofacial dyssynostosis10.1

Graphical network of the top 20 diseases related to Crouzon Syndrome:



Diseases related to crouzon syndrome

Symptoms for Crouzon Syndrome

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Symptoms by clinical synopsis from OMIM:

123500

Clinical features from OMIM:

123500

Symptoms:

 51 (show all 32)
  • skull/cranial anomalies
  • craniostenosis/craniosynostosis/sutural synostosis
  • frontal bossing/prominent forehead
  • high forehead
  • facial dysmorphism
  • autosomal dominant inheritance
  • turricephaly/oxycephaly/acrocephaly
  • brachycephaly/flat occiput
  • hypertelorism
  • hypoplastic maxillary bones/zygomatic bones/maxillary hypoplasia
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • strabismus/squint
  • ptosis
  • conductive deafness/hearing loss
  • arnold-chiari anomaly
  • cranial hypertension
  • coloboma of iris
  • optic nerve anomaly/optic atrophy/anomaly of the papilla
  • visual loss/blindness/amblyopia
  • beaked nose
  • choanal atresia
  • high vaulted/narrow palate
  • external auditory canal atresia/stenosis/agenesis
  • hearing loss/hypoacusia/deafness
  • sacro-coccyx/sacrum anomaly
  • irregular/patchy skin hypopigmentation
  • pigmented naevi/naevus pigmentosus/lentigo
  • acanthosis nigricans
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hydrocephaly
  • cerebellum/cerebellar vermis anomaly/agenesis/hypoplasia
  • facial pain/cephalalgia/migraine

HPO human phenotypes related to Crouzon Syndrome:

(show all 48)
id Description Frequency HPO Source Accession
1 high forehead hallmark (90%) HP:0000348
2 craniosynostosis hallmark (90%) HP:0001363
3 abnormal facial shape hallmark (90%) HP:0001999
4 frontal bossing hallmark (90%) HP:0002007
5 hypertelorism typical (50%) HP:0000316
6 conductive hearing impairment typical (50%) HP:0000405
7 strabismus typical (50%) HP:0000486
8 ptosis typical (50%) HP:0000508
9 arnold-chiari malformation typical (50%) HP:0002308
10 increased intracranial pressure typical (50%) HP:0002516
11 abnormality of the palate occasional (7.5%) HP:0000174
12 hydrocephalus occasional (7.5%) HP:0000238
13 atresia of the external auditory canal occasional (7.5%) HP:0000413
14 convex nasal ridge occasional (7.5%) HP:0000444
15 choanal atresia occasional (7.5%) HP:0000453
16 visual impairment occasional (7.5%) HP:0000505
17 iris coloboma occasional (7.5%) HP:0000612
18 optic atrophy occasional (7.5%) HP:0000648
19 acanthosis nigricans occasional (7.5%) HP:0000956
20 melanocytic nevus occasional (7.5%) HP:0000995
21 hypopigmented skin patches occasional (7.5%) HP:0001053
22 migraine occasional (7.5%) HP:0002076
23 respiratory insufficiency occasional (7.5%) HP:0002093
24 abnormality of the sacrum occasional (7.5%) HP:0005107
25 aplasia/hypoplasia of the cerebellum occasional (7.5%) HP:0007360
26 autosomal dominant inheritance HP:0000006
27 brachycephaly HP:0000248
28 mandibular prognathia HP:0000303
29 hypertelorism HP:0000316
30 hypoplasia of the maxilla HP:0000327
31 conductive hearing impairment HP:0000405
32 atresia of the external auditory canal HP:0000413
33 strabismus HP:0000486
34 visual impairment HP:0000505
35 conjunctivitis HP:0000509
36 shallow orbits HP:0000586
37 optic atrophy HP:0000648
38 dental crowding HP:0000678
39 intellectual disability HP:0001249
40 seizures HP:0001250
41 abnormality of the nasopharynx HP:0001739
42 frontal bossing HP:0002007
43 abnormality of the cervical spine HP:0003319
44 craniofacial dysostosis HP:0004439
45 coronal craniosynostosis HP:0004440
46 sagittal craniosynostosis HP:0004442
47 lambdoidal craniosynostosis HP:0004443
48 sleep apnea HP:0010535

Drugs & Therapeutics for Crouzon Syndrome

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Drugs for Crouzon Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Tranexamic AcidapprovedPhase 4, Phase 31991197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
KBioSS_001871
 
LS-56611
LS-56612
LT00159441
Lysteda
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic Acid
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
2CoagulantsPhase 4, Phase 3, Phase 2, Phase 1983
3Calcium, DietaryPhase 43529
4
PaclitaxelapprovedPhase 2250533069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
5
Aminocaproic Acidapproved, investigationalPhase 2, Phase 12360-32-2564
Synonyms:
.epsilon. S
.epsilon.-Aminocaproic acid
.epsilon.-Aminohexanoic acid
.epsilon.-Leucine
.epsilon.-Norleucine
.omega.-Aminocaproic acid
.omega.-Aminohexanoic acid
1319-82-0
177 J.D
177 J.D.
1cea
3kiv
6 Aminocaproic Acid
6 Aminohexanoic Acid
6-Amino-Hexanoate
6-Amino-Hexanoic acid
6-Amino-N-hexanoate
6-Amino-N-hexanoic acid
6-Amino-n-hexanoic acid
6-Aminocaproate
6-Aminocaproic acid
6-Aminohexanoate
6-Aminohexanoic acid
6-amino-hexanoic acid
6-amino-n-caproate
6-amino-n-caproic acid
6-aminohexanoate
6-aminohexanoic acid
60-32-2
87867-96-7
93208-38-9
A 7824
A0312
A2504_SIGMA
A7824_SIGMA
AB00051911
AC-035
AC1L19IP
AC1Q54EY
ACS
AI3-14512
AKOS000118734
AMICAR
AMINOCAPROIC
Acepramin
Acepramine
Acid, 6-Aminocaproic
Acid, 6-Aminohexanoic
Acid, epsilon-Aminocaproic
Acide aminocaproique
Acide aminocaproique [French]
Acide aminocaproique [INN-French]
Acide aminocaproque
Acide aminocaproïque
Acido aminocaproico
Acido aminocaproico [DCIT,Spanish]
Acido aminocaproico [INN-Spanish]
Acidum Aminocaproicum
Acidum aminocaproicum
Acidum aminocaproicum [INN-Latin]
Acidum aminocaproicum [Latin]
Acikaprin
Afibrin
Ahx
Amicar
Amicar (TN)
Amicar, |A-amino caproic acid, |A-Ahx, 6-aminohexanoic acid, Aminocaproic acid
Amikar
Aminocaproate
Aminocaproic
Aminocaproic Acid
Aminocaproic Acid In Plastic Container
Aminocaproic Acids
Aminocaproic acid
Aminocaproic acid (USP)
Aminocaproic acid (USP/INN)
Aminocaproic acid [USAN:BAN:INN]
Aminocaproic acid [USAN:INN:BAN]
Aminocapronsäure
Aminohexanoic acid
Aminokapron
Atsemin
BIDD:GT0162
BPBio1_001056
BRN 0906872
BSPBio_000960
C02378
C3BDD377-8F43-4BEC-900A-D5850050BA82
C6H13NO2
CAS-60-32-2
CBDivE_004370
CCRIS 7706
CHEBI:16586
CHEMBL1046
CID564
CL 10304
CL-10304
CY 116
CY-116
CY116
Caplamin
Capracid
Capralense
Capramol
Capranol
Caproamin
Caprocid
Caprolisin
D00160
D015119
DB00513
DB04134
DivK1c_000551
EACA
EACS
EINECS 200-469-3
EPSILON-AMINOCAPROIC ACID
EU-0100082
Eaca
Eaca kabi
 
Epsamon
Epsicaprom
Epsicapron
Epsikapron
Epsilcapramin
Epsilcapramine
Epsillon-Aminocaproate
Epsillon-Aminocaproic acid
Epsillon-Aminocaproic acid' Epsilcapramin
Epsilon S
Epsilon-Aminocaproic Acid
Epsilon-Aminocapronsaeure
Epsilon-aminocapronzuur
H-6-Ahx-OH
H-EAhx-OH
H-epsilon-Acp-OH
HEXANOIC ACID,6-AMINO
HMS1570P22
HMS1920C07
HMS2091I07
HMS501L13
HSDB 3005
Hemocaprol
Hemopar
Hepin
IDI1_000551
InChI=1/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9
Ipsilon
JD 177
KBio1_000551
KBio2_000398
KBio2_002966
KBio2_005534
KBioGR_000586
KBioSS_000398
Kyselina omega-aminokapronova
Kyselina omega-aminokapronova [Czech]
LMFA01100035
LS-7191
Lopac-A-7824
Lopac0_000082
MLS001335991
MLS002695931
MolPort-001-779-881
NCGC00015092-01
NCGC00015092-02
NCGC00015092-03
NCGC00015092-07
NCGC00093587-01
NCGC00093587-02
NCGC00093587-03
NCGC00093587-04
NINDS_000551
NSC 26154
NSC 400230
NSC-26154
NSC212532
NSC26154
NSC400230
Omega-Aminocaproate
Omega-Aminocaproic acid
Omega-Aminohexanoate
Omega-Aminohexanoic acid
Prestwick0_000960
Prestwick1_000960
Prestwick2_000960
Prestwick3_000960
Respramin
S04-0132
S1671_Selleck
SMR000059162
SPBio_000202
SPBio_003109
SPECTRUM1500114
STK246894
Spectrum2_000131
Spectrum4_000143
Spectrum5_000780
Spectrum_000038
TL8003819
UNII-U6F3787206
WLN: Z5VQ
Z
acide aminocaproque
amicar
bmse000394
e-Amino-N-hexanoate
e-Amino-N-hexanoic acid
e-Aminocaproate
e-Aminocaproic acid
e-Aminocaproic acid USP
e-Aminohexanoate
e-Aminohexanoic acid
e-Leucine
e-Norleucine
epsilcapramine
epsilon Aminocaproic Acid
epsilon S
epsilon-Ahx
epsilon-Amino-N-hexanoate
epsilon-Amino-N-hexanoic acid
epsilon-Amino-n-caproic acid
epsilon-Amino-n-hexanoic acid
epsilon-Aminocaproate
epsilon-Aminocaproic acid
epsilon-Aminocaproic acid (JAN)
epsilon-Aminocaproic acid USP
epsilon-Aminohexanoate
epsilon-Aminohexanoic acid
epsilon-Leucine
epsilon-Norleucine
epsilon-S
epsilon-aminocaproate
nchembio.104-comp21
nchembio.2007.30-comp14
omega-Aminocaproic acid
omega-Aminohexanoic acid
w-Aminocaproate
w-Aminocaproic acid
w-Aminohexanoate
w-Aminohexanoic acid
Ácido aminocapróico
6
Valproic Acidapproved, investigationalPhase 230299-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-PROPYL-pentanoic acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Depakote ER
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaeure
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VALPROIC acid
VPA
Valcote
Valparin
Valproate
Valproate Semisodium
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic
Valproic Acid
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
7
SimvastatinapprovedPhase 248279902-63-954454
Synonyms:
(+)-Simvastatin
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
79902-63-9
AC-1530
AC1L1H1F
AKOS005111006
ARONIS24119
BCBcMAP01_000007
BIDD:GT0769
BPBio1_001001
BRD-K22134346-001-05-8
BRN 4768037
BSPBio_000909
BSPBio_002337
Bio-0672
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,*aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
C25H38O5
CCRIS 7558
CHEBI:9150
CHEMBL1064
CID54454
CPD000718785
Cholestat
Coledis
Colemin
Corolin
D00434
D019821
DRG-0320
Denan
DivK1c_006991
Eucor
HMS1570N11
HMS1922H13
HMS2089D12
HMS2093E06
HSDB 7208
InChI=1/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
KBio1_001935
KBio2_002197
KBio2_004765
KBio2_007333
KBio3_001557
KBioGR_001244
KBioSS_002197
KS-1113
Kolestevan
L 644128-000U
LS-46264
Labistatin
Lipex
Lipinorm
Liponorm
Lipovas
Lodales
MK 0733
MK 733
MK-0733
MK-733
MK733
MLS001304029
MLS001333077
MLS001333078
 
MLS002154038
Medipo
Modutrol
MolPort-002-507-345
MolPort-002-885-862
NCGC00017324-01
NCGC00017324-02
NCGC00017324-03
Nivelipol
Nor-Vastina
Pantok
Pepstatin
Prestwick0_000865
Prestwick1_000865
Prestwick2_000865
Prestwick3_000865
Prestwick_171
Rechol
Rendapid
S1792_Selleck
S6196_SIGMA
SAM002589969
SMR000718785
SPBio_001881
SPBio_002830
SPECTRUM1504236
STK801938
Simcor
Simovil
Simvast CR
Simvastatin
Simvastatin & Primycin
Simvastatin (JAN/USP/INN)
Simvastatin [USAN:INN:BAN]
Simvastatin [Usan:Ban:Inn]
Simvastatin lactone
Simvastatin, Compactin
Simvastatina
Simvastatina [Spanish]
Simvastatine
Simvastatine [French]
Simvastatinum
Simvastatinum [Latin]
Simvotin
Sinvacor
Sinvascor
Sivastin
SpecPlus_000895
Spectrum2_001671
Spectrum3_000669
Spectrum4_000632
Spectrum5_001428
Spectrum_001717
Statin
Synvinolin
TNP00259
UNII-AGG2FN16EV
Valemia
Vasotenal
Velostatin
Vytorin
ZINC03780893
Zocor
Zocor (TN)
Zocor, Simlup, Simcard, Simvacor, Simvoget, Zorced, Simvastatin
Zocord
[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1 alpha,3 alpha,7 beta,8 beta(2S*,4S*),-8a beta
nchembio790-comp16
simvastatin
8
BenzocaineapprovedPhase 1, Phase 215361994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
9
ponatinibapprovedPhase 226943319-70-824826799
Synonyms:
AP 24534
AP24534
 
Iclusig
Ponatinib Hydrochloride
Ponatinibum
ponatinib
10tannic acidNutraceuticalPhase 1, Phase 21536
11tyrosineNutraceuticalPhase 1, Phase 2547
12
Mentholapproved17482216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
999 Itch Relief
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
Absorbine Back Therapeutic Pain Relief
Absorbine Jr
Absorbine Jr Ultra Strength Pain Relieving
Absorbine Jr.
Absorbine Jr. Back
Algomend Pain Relief
Alhua Huogan Pain Relieving Patch
Aloemint Skin Aid
Amar Ice
Analgesic
Anc Neverpain External Analgesic
Anti Itch
Army Health Pain Reliever
Arthri-support
Arthri-zen Relief
Arthripain Relief
Arthritis Relief
Aspercreme Heat
Aspercreme Max No Mess Roll On
Assured Cold N Hot Pain Relief Menthol
Assured Extra Strength Cold N Hot
Assured Ice Cold Topical Analgesic
Assured Muscle Rub
Assured Pain Relief Hot Menthol
Atopalm Pain Relieving
Aurorae Healing Pain Relieving Roll-on
Avapta
Avedana Pain Relieving Roll On
Avedana Pain-relieving
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
Babyganics Cold Relief Chest Rub
Barox
Barox BODY CARE MASSAGE
Barox Body Care Massage Relax Refresh Revital
Being Well Extra Strength Menthol Heat
Bengay Ultra Strength Large Size
Bengay Ultra Strength Pain Relieving Large Size
Bengay Ultra Strength Pain Relieving Regular Size
Bengay Ultra Strength Regular Size
Bengay Vanishing Scent
Bengay Zero Degrees Menthol Pain Relieving
Bentasil SUGAR FREE BLACKCURRANT SOFT Texture
Bentasil SUGAR FREE CHERRY SOFT Texture
Bentasil SUGAR FREE HONEY LEMON SOFT Texture
Berri-freez
Besthealth Cherry
Besthealth Cough Suppressant Sugar Free Black Cherry Flavor
Besthealth Cough Suppressant Sugar Free Honey Lemon Flavor
Besthealth Honey Lemon
Besthealth Menthol
Bio 2 Brazilian Heat Brazilian Heat
Bio-scriptives Extreme Pr
Bioblast Pain Relief
Bioflexor
Biofreeze
Biofreeze Colorless
Biofreeze Colorless Roll-on
Biofreeze Roll-on
Biorelief Ice Pain Relieving
Blistex Ivarest Medicated Poison Ivy Cleansing Foam
Blue Gel Pain Relieving
Blue Ice
Blue Ice Analgesic
Blue Ice Analgesic Gel
Blue Ice Pain Relieving
Body
Budpack Muscle Rub
Budpak Muscle Rub
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Canker Complete Canker Sore Relief
Caswell No. 540
Celadrin
Cepacol Sore Throat From Post Nasal Drip
Cepacol Sore Throat Regular Strength
Ching Wan Hung Soothing Herbal Balm
Choice Personal Care Theraputic Blue Ice
Cold Hot Patch
Cold Spot Point Relief
Coldaid
Cool N Heat Patch For Back Extra Strength
Coralite Extra Strength Menthol Pain Relief Sleeve - Knee
Coralite Extra Strength Menthol Pain Relief Sleeve - Wrist
Coralite Pain Relief
Counteract Cough Drops Honey Lemon
Counteract Cough Drops Orchard Cherry
Cryogel Island Rain Natural Pain Relieving Vitaminerals
Cvs Cold Hot Medicated
Cvs Soothing Itch Relief
Cvs Sore Muscle Rub Vanishing Scent
Cvs Therapeutic Menthol Gel
Cvs Therapeutic Menthol Pain Reliever
Cvs Tropical Citrus Cough
Cvs Ultra Strength Pain Relieving
Cvs Vanishing Scent Muscle Rub
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
Dg Health Extra Strength Medicated
Dg Health Pain Relieving
Dg Ice Cold Analgesic
Diapedic Foot Treatment
DivK1c_000820
Dorflex Icy Hot Flexible, Large
Dorflex Icy Hot Flexible, Small
Dorflex Icy Hot Flexible, XL
Dr. Blue
Dt Ice Cold Analgesic
Dual Action Cherry Cough Suppressant Oral Anesthetic
Dynafreeze
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
Easy
Eb301ap Pain Relief
Eb301ct Bruise Pain Relief
Eb302 Arthritis Relief
Ecolyptus Pain Relieving Muscle Rub
Efac Pain Relieving
Elgin Pain Relief
Equaline Blue Ice Pain Relieving
Equate Menthol Extra Strength
Eros Iron Man
Eucalyptamint
Eucerin Calming Itch Relief Treatment
Extra Strength Cold N Hot Pain Relief Medicated
Extra Strength Pain Relief Therapy
Extra Strength Stopain Cold Pain Relieving
Extra Strength Stopain Cold Pain Relieving Roll On
FEMA No. 2665
Family Care Maximum Strength Medicated Anti Itch
Fast Freeze
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
Flexall Pain Relieving
Flexgen
Fluaid
Foot Works Achy Foot Massager Pain Relieving
Gold Bond Foot Extra Strength
Gold Bond Medicated Foot
Gold Bond Pain Relieving Foot
Gold Bond Pain Relieving Foot Roll On
Green Bamboo
Green Guard Cough Drop Relief
HMS1922G13
HMS2092L14
HMS502I22
HSDB 5662
HSDB 593
Halls Apple Cider
Halls Butterscotch
Halls Cherry
Halls Extra Strong Menthol
Halls Honey Lemon
Halls Ice Peppermint
Halls MENTHO-LYPTUS
Halls Melon Splash
Halls Menthol
Halls Mentholyptus
Halls Mocha Mint
Halls Naturals Honey Lemon Chamomile
Halls Plus Cherry
Halls Plus Honey
Halls Plus Strawberry
Halls Spearmint
Halls Strawberry
Halls Sugar Free Black Cherry
Halls Sugar Free Citrus Blend
Halls Sugar Free Extra Strong Menthol
Halls Sugar Free Honey Berry
Halls Sugar Free Honey Lemon
Halls Sugar Free Mountain Menthol
Halls Tropical Fruit
Hallsmelon Splash Melon Splash
Hallssugar Free Extra Sugar Free Extra Strong Menthol
Han Honey Loquat Syrup
Hanbang Cataplasma
Harmon Extra Strength Pain Relieving
Harmon Extra Strength Pain Relieving Roll-on
Headache crystals
Health Smart Medicated Foot
Herbion Naturals Honey Lemon
Herbion Naturals Honey Lemon Cough Drops
Herbion Naturals Honey-Lemon Cough Drops
Herbion Naturals Mint Cough Drops
Herbion Naturals Orange
Herbion Naturals Orange Cough Drops
Hexahydrothymol
Hielo Ardiente
Honibe
 
Hot Ice Soothing Analgesic Gel
Huitomi Slimming Sports
Humphreys Bendito Alcoholado
I06-1216
I14-7371
IDI1_000820
Ice
Ice Cold Analgesic
Ice Cold Topical Analgesic Gel
Ice External Analgesic Leader
Ice Quake
Ice Quake Muscle Rub
Icy Cool Maximum Strength
Icy Hot
Icy Hot Back
Icy Hot Medicated
Icy Hot Medicated No Mess Applicator
Icy Hot Medicated Roll Large
Icy Hot Medicated Roll Medium
Icy Hot Medicated Roll, Large
Icy Hot Medicated Roll, Medium
Icy Hot Medicated, Advanced Relief
Icy Hot Medicated, Back
Icy Hot Medicated, XL
Icy Hot Naturals
Icy Hot Power Gel
Icy Hot Vanishing Scent
Icyhot Medicated
Imada Four Seasons Safe Analgesic Balm
Jakemans Blueberry
Jakemans Cherry
Jakemans Peppermint
K2 Cold Therapy
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
Kay Medic Menthol Pain Relief
Kool Comfort
Kool Comfort Pain Relieving Roll-on
Kpp Triple Action
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
La Jiao Feng Shi Gao
Lander Polar Ice
Leader Cough Drops Cherry Flavor
Leader Cough Drops Honey Lemon
Leader Cough Drops Menthol Flavor
Leader Extra Strength Medicated Pain Relief Patch
Leader Sugar Free Cough Drops Black Cherry
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
Linkus Lozenges Cough Suppressant/Oral Anesthetic
Low Sugar Cherry Flavor Fishermans Friend Menthol Cough Suppressant
Ludens Honey Lemon Throat Drops
Ludens Honey Licorice Throat Drops
Ludens Original Menthol Throat Drops
Lurosil
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Makesense Extra Strength Muscle Rub
Maxfit Freeze Gel
Maybelline New York Baby Lips Dr Rescue Medicated Balm
Medi First Plus Cherry Cough Drops
Medi-first Cherry Cough Drops
Medic Ice
Medicated Body Powder
Medicated Pain Relief
Mediflex
Medique Medikoff Drops
Medique Sugar Free Medikoff Drops
Meditowel PAIN RELIEF
Meijer Cherry Cough Drops
Meijer Honey Lemon Cough Drops
Meijer Menthol Cough Drops
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol Fresh Cough Suppressant
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Mentholatum Pain Relief Extra Strength
Mentholatum Sports Pain Relief Cold
Menthomenthol
Menthyl alcohol
Mineral Ice Pain Relieving
Miracle Foot Repair
Miracle Foot Repair Cream
Miracle Of Aloe Rub Roll On
Miracle Pain Cream
Moisture Therapy Anti-Itch
MolPort-000-849-729
MolPort-001-793-392
Moore Medical Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Black Cherry Cough Suppressant/anesthetic Drops
Moore Medical Sugar Free Menthol Cough Suppressant/anesthetic Drops
Mr Dudleys Topical Pain Relief
Muscle
Muscle Rub Ultra Strength Pain Relieving
Myo-breathe
Myorx Low Dose Pain Relieving
Myorx Pain Relieving
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Nan San Easy Flex Pain Relieving
Natural Cherry Honey Herb Throat Drops
Natural Herb cough drop
Natural Honey Herb Cough Suppressant Throat Drops
Natural Lemon Mint Herb Throat Drops
Natural Pain Relieving Lavender Breeze Cryogel
Natures Choice Cool Hot Ice
Natures Sunshine Products Everflex Topical Analgesic Pain Relief
Neoisomenthol
Nice Assorted
Nice Cherry
Nice Citrus
Nice Cool Mint
Nice Honey Lemon
Nice Menthol
No Pain More Gain
North Cough Drop
Numotizine
Olbas Lozenges Maximun Strength
Olbas Pastilles
Original Extra Strong All Natural Fishermans Friend Menthol Cough Suppressant
Ortho-nesic
Osmoflex
Oxyrub Pain Relief
Pain Relief Balmpreferred Plus Ph Preferred Plus Pharmacy
Pain Relief Therapy Patch
Pain Reliever
Pain Relieving
Pain Relieving Analgesic
Pain Relieving Patch
Pain Relieving Patch Ultra Strength
Pain Relieving Patch Ultra Strength ULTRA STRENGTH
Panitrol XR
Paraid Extra Strength Menthol Pain Relief Sleeve Knee Large Ankles Elbows
Patch Scherer Labs
Patch Walgreens
Peppermint camphor
Perfect Purity Hotice
Perfect Purity Medicated Foot Powder
Perform
Personal Care Extra Strength Cold Hot
Personal Care Ice Cold
Plaster MandAHerbalPlaster
Po Sum On Medicated
Polar Frost Cold
Power Relief
Preferred Plus Body Powder
Premier Value Medicated Foot Powder
Q Health Pain Relief Spray
Quickflex
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Raw Heat
Raw Ice
Reactice Reactivating Ice Baume
Red Lion Relief
Relief Pain Relieving Cream
Rexall Vanishing Scent Pain Relieving
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Screamin Menthol Toast
Sella Natural
Skin So Soft Bug Guard Plusitch Relief itch relief
Smith Bros Honey Lemon Cough Drops
Smith Bros Menthol Eucalyptus Cough Drops
Smith Bros Sugar-free Black Cherry Cough Drops
Sof Skin Icy Blue
Sofskin Ice Analgesic
Sombra Cool Therapy
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Stopain Cold Pain Relieving
Stopain Cold Professional Strength Pain Relieving
Stopain Extra Strength Pain Relieving
Sub-zero COOL PAIN RELIEVING
Sugar Free Cherry Fishermans Friend Menthol Cough Suppressant
Sugar Free Cherry Herb Throat Drops
Sugar Free Lemon Mint Herb Throat Drops
Sugar Free Mountain Herb Cough Suppressant Throat Drops
Sugar Free Original Swiss Herb Cough Suppressant Throat Drops
Sugar Free Refreshing Mint Fishermans Friend Menthol Cough Suppressant
Sugar Free Swiss Cherry Herb Throat Drops
The Medicine Shoppe Extra Strength Pain Relieving
The Original Natural Herb Cough Drops
Therafreeze
Theraid
Therapeutic Relief Preferred Plus Pharmacy
Theraplus Plus
Throat Coat
Tianhe Guben Yaoshen Tie Gao
Top Care Medicated
Topcare Medicated
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
Ultra Strength Stopain Pain Relieving
Us Favorite Cold Pain Relieving
Vaporizing Colds Rub
Vicks Vapodrops Cough Relief
Vitaminerals Inc. Cryogel Natural Pain Relieving
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
Walgreens Aloe Vera Cooling
Watermelon Frost Sore Throat
Wellpatch Backache Pain Relief
Xtracare Ice Cold Topical Analgesic Gel
Youngevity Invision CM
Yun Xiang Jing
ZINC01482164
Zhong Hua Jiu Patch
Zims Arnica Max
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
13
Adenosineapproved, investigational34058-61-760961
Synonyms:
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
1-(6-Amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose
1odi
2fqy
2gl0
30143-02-3
4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside
46946-45-6
46969-16-8
58-61-7
6-Amino-9-.beta.-ribofuranosyl-9H-purine
6-Amino-9-beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-D-ribofuranosyl-9H-purine
6-Amino-9beta-delta-ribofuranosyl-9H-purine
9-(beta-D-Arabinofuranosyl)adenine
9-beta-D-Arabinofuranosyladenine
9-beta-D-Ribofuranosidoadenine
9-beta-D-Ribofuranosyl-9H-purin-6-amine
9-beta-D-Ribofuranosyladenine
9-beta-delta-Arabinofuranosyladenine
9-beta-delta-Ribofuranosidoadenine
9-beta-delta-Ribofuranosyl-9H-purin-6-amine
9-beta-delta-Ribofuranosyladenine
9beta-D-Ribofuranosyladenine
9beta-D-ribofuranosyl-9H-Purin-6-amine
9beta-delta-Ribofuranosyladenine
9beta-delta-ribofuranosyl-9H-Purin-6-amine
A0152
A4036_SIGMA
A9251_SIGMA
AC1L1U8O
AC1Q1ID3
AC1Q52XU
ADN
AI3-52413
Ade-Rib
Ade-rib
Adenin riboside
Adenine 9-beta-D-arabinofuranoside
Adenine deoxyribonucleoside
Adenine nucleoside
Adenine riboside
Adenine-9-beta-D-ribofuranoside
Adenine-9beta-D-Ribofuranoside
Adenine-9beta-delta-Ribofuranoside
Adenocard
Adenocard (TN)
Adenocard, Adenosine
Adenocor
Adenoscan
Adenoscan (TN)
Adenosin
Adenosin [German]
Adenosina
Adenosine
Adenosine (JAN/USP)
Adenosine [USAN:BAN]
Adenosine, homopolymer
Adenosinum
Adensoine
Adenyldeoxyriboside
Ado
Adénosine
BB_NC-0565
BSPBio_001796
Bio1_000437
 
Bio1_000926
Bio1_001415
Boniton
C00212
CCRIS 2557
CHEBI:16335
CHEMBL477
CID60961
Caswell No. 010B
D000241
D00045
DB00640
Deoxyadenosine
Desoxyadenosine
EA6C60C2-6AFB-4264-A2F0-541373DB950E
EINECS 200-389-9
FT-0082881
HMS1920A13
HMS2091G13
KBio3_001296
LS-15085
MEDR-640
MLS000069638
MLS002153227
MolPort-001-838-229
Myocol
NCGC00023673-03
NCGC00023673-04
NCGC00023673-05
NCGC00023673-06
NCGC00023673-07
NSC 627048
NSC 7652
NSC627048
NSC7652
Nucleocardyl
Pallacor
Polyadenosine
Polyriboadenosine
S1647_Selleck
SDCCGMLS-0003108.P003
SMR000058216
SPBio_001194
SPECTRUM1500107
SR 96225
SR-96225
SUN-Y4001
Sandesin
Spectrum2_001257
Spectrum3_000288
TL8003749
UNII-K72T3FS567
USAF CB-10
V0098
Vidarabine
ZINC02169830
adenine-D-ribose
adenosine
b-D-Adenosine
beta-Adenosine
beta-D-Adenosine
beta-D-Ribofuranoside, adenine-9
beta-delta-Adenosine
bmse000061
nchembio.143-comp9
nchembio.186-comp109
nchembio.2007.56-comp13
nchembio.64-comp4
nchembio706-5

Interventional clinical trials:

(show all 48)
idNameStatusNCT IDPhase
1The Efficacy and Population Pharmacokinetics of Tranexamic Acid for Craniosynostosis SurgeryRecruitingNCT02188576Phase 4
2Tranexamic Acid for Craniofacial SurgeryTerminatedNCT00722436Phase 4
3Comparison of Allogenix Plus Demineralized Bone Matrix and Autogenous Bone Dust Versus Autogenous Bone Dust Alone in Ossification of Small Calvarial Defects, a Pilot Study.WithdrawnNCT01006148Phase 4
4Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic AcidRecruitingNCT01094977Phase 3
5Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative CellsCompletedNCT01674439Phase 2
6Treatment of the Cholesterol Defect in Smith-Lemli-Opitz SyndromeCompletedNCT00272844Phase 1, Phase 2
7Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz SyndromeCompletedNCT00114634Phase 2
8Prenatal Screening For Smith-Lemli-Opitz SyndromeCompletedNCT00070850Phase 2
9Simvastatin Therapy in Smith-Lemli-Opitz SyndromeCompletedNCT00064792Phase 2
10Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic TrialCompletedNCT01619644Phase 2
11A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome PatientsCompletedNCT00961896Phase 2
12Efficacy and Safety of AZD4547 Versus Paclitaxel in Advanced Gastric or Gastro-oesophageal Junction Cancer PatientsCompletedNCT01457846Phase 2
13Phase II Study of Dietary Cholesterol for Smith-Lemli-Opitz SyndromeRecruitingNCT00004347Phase 2
14Efficacy of Amicar for Children Having Craniofacial SurgeryRecruitingNCT02229968Phase 2
15Phase 1/2 Study of ARQ 087 in Adult Subjects With Advanced Solid Tumors With FGFR Genetic AlterationsRecruitingNCT01752920Phase 1, Phase 2
16A Phase II, Single Arm Study of BGJ398 in Patients With Advanced CholangiocarcinomaRecruitingNCT02150967Phase 2
17Dovitinib for Gastric Cancer With FGFR2 AmplificationRecruitingNCT01719549Phase 2
18Ponatinib Hydrochloride in Treating Patients With Advanced Biliary Cancer With FGFR2 FusionsRecruitingNCT02265341Phase 2
19Amicar Pharmacokinetics of Children Having Craniofacial SurgeryCompletedNCT00912119Phase 1
20Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2)RecruitingNCT02368951Phase 1
21Estimation of the Carrier Frequency and Incidence of Smith-Lemli-Opitz Syndrome in African AmericansCompletedNCT00017732
22Child and Infant Learning ProjectCompletedNCT00077831
23Genetic Analysis of Craniosynostosis, Philadelphia TypeCompletedNCT00367796
24Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary ResultsCompletedNCT01672619
25Study of Quality of Life in Freeman-Sheldon Syndrome and Related ConditionsRecruitingNCT01307475
26Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon SyndromeRecruitingNCT01144741
27Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related ConditionsRecruitingNCT01306994
28Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)RecruitingNCT02224677
29Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)RecruitingNCT01773278
30SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol SupplementationRecruitingNCT01434745
31Sterol and Isoprenoid Disease Research Consortium: Smith-Lemli-Opitz SyndromeRecruitingNCT01356420
32Study of Smith-Lemli-Opitz SyndromeRecruitingNCT00001721
33MRI for Non-invasive Evaluation of Brain StressRecruitingNCT01898650
34Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled TrialRecruitingNCT02180321
35Clinical and Molecular Characterisation of Orofaciodigital Syndromes and Other Clinical Phenotypes Secondary to Mutations in the OFD1 GeneRecruitingNCT01962129
36UAB HRFD Core Center: Core A: The Hepato/Renal Fibrocystic Diseases Translational ResourceRecruitingNCT01401998
37Osteogenic Profiling of Tissue From Children With CraniosynostosisRecruitingNCT00773643
38Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)RecruitingNCT00106977
39Clinical and Molecular Investigations Into CiliopathiesRecruitingNCT00068224
40Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced OsteomalaciaRecruitingNCT01660308
41Qualitative and Quantitative Study Which Aims to Determine the Specifics of the Announcement for the Diagnosis of Patients With Craniosynostosis and Their Parents to Better Support Them in Their CareActive, not recruitingNCT02287805
42National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular ConditionsActive, not recruitingNCT01322165
43Role of Mesenchymal Stem Cells in Fat GraftingNot yet recruitingNCT02494752
44Hanger Helmet StudyNot yet recruitingNCT02561728
45Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis RepairNot yet recruitingNCT02483702
46The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITUNot yet recruitingNCT01996163
47A Long-Term Study of Cholesterol Supplements for Smith-Lemli-Opitz SyndromeWithdrawnNCT01413425
48Endoscopic Treatment for Isolated, Single Suture CraniosynostosisWithdrawnNCT00769847

Search NIH Clinical Center for Crouzon Syndrome


Cochrane evidence based reviews: Craniofacial Dysostosis

Genetic Tests for Crouzon Syndrome

About this section

Genetic tests related to Crouzon Syndrome:

id Genetic test Affiliating Genes
1 Crouzon Syndrome22 24 FGFR2

Anatomical Context for Crouzon Syndrome

About this section

MalaCards organs/tissues related to Crouzon Syndrome:

33
Bone, Eye, Skin, Cerebellum, Lung, Trachea, Brain

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Crouzon Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 BoneRostral Skull Membranous BonesIntramembrenous Osteocytes Affected by disease

Animal Models for Crouzon Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Crouzon Syndrome:

38 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3FGF2, FGFR1, FGFR2, FGFR3, MSX2
2MP:00053719.0ALX3, FGFR1, FGFR2, FGFR3, MSX2
3MP:00053678.9DCN, FGFR1, FGFR2, FGFR3, TGFB1
4MP:00020068.7DCN, FGF2, FGFR2, FGFR3, TGFB1
5MP:00028738.7ERF, FGF1, FGFR1, FGFR2, FGFR3, MSX2
6MP:00053888.5ALX3, DCN, FGFR2, FGFR3, TGFB1
7MP:00053698.5DCN, FGF2, FGFR1, FGFR2, MSX2, TGFB1
8MP:00107718.4DCN, FGFR1, FGFR2, FGFR3, MSX2, TGFB1
9MP:00053808.2ALX3, ERF, FGFR1, FGFR2, MSX2, TGFB1
10MP:00053817.9ALX3, DCN, FGFR1, FGFR2, FGFR3, MSX2
11MP:00053797.8ALX3, DCN, FGFR1, FGFR2, MSX2, TGFB1
12MP:00053907.8ALX3, DCN, ERF, FGF2, FGFR1, FGFR2
13MP:00053897.7ALX3, DCN, FGF2, FGFR2, FGFR3, TGFB1
14MP:00053827.6ALX3, DCN, ERF, FGFR1, FGFR2, FGFR3
15MP:00053917.5ALX3, DCN, FGF2, FGFR1, FGFR2, FGFR3
16MP:00053787.4ALX3, DCN, ERF, FGFR1, FGFR2, FGFR3
17MP:00053977.2DCN, ERF, FGF1, FGF2, FGFR2, FGFR3
18MP:00107687.1ALX3, DCN, ERF, FGF2, FGFR1, FGFR2
19MP:00053767.1ALX3, DCN, ERF, FGF1, FGF2, FGFR2
20MP:00053846.8ALX3, DCN, ERF, FGF13, FGF2, FGFR1
21MP:00053866.5ALX3, DCN, FGF13, FGF2, FGFR1, FGFR2
22MP:00036316.0ALX3, ERF, FGF1, FGF13, FGF2, FGFR1

Publications for Crouzon Syndrome

About this section

Articles related to Crouzon Syndrome:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Monobloc Le Fort III Distraction Osteogenesis for Correction of Severe Fronto-orbital and Midface Hypoplasia in Pediatric Crouzon Syndrome. (25650655)
2015
2
Crouzon Syndrome: Visual Diagnosis. (26283152)
2015
3
Crouzon Syndrome: Relationship of Eye Movements to Pattern Strabismus. (26176876)
2015
4
Crouzon syndrome with bony upper airway obstruction: case report and review literature. (24828762)
2014
5
Three-dimensional precise orientation of bilateral auricular trial prosthesis using a facebow for a young adult with Crouzon syndrome. (25096652)
2014
6
Orbitofrontal monobloc advancement for Crouzon syndrome. (24530078)
2014
7
Analysis of FGFR2 gene mutations in two Chinese families with Crouzon syndrome]. (24928000)
2014
8
Identification of causative mutation in a korean family with crouzon syndrome using whole exome sequencing. (25361936)
2014
9
A case of Crouzon syndrome treated by simultaneous bimaxillary distraction. (23886558)
2014
10
Management of Crouzon syndrome in an adult patient. (24378546)
2013
11
Psychosocial conditions in adults with Crouzon syndrome: a follow-up study of 31 Swedish patients. (24328900)
2013
12
Crouzon syndrome and Bent bone dysplasia associated with mutations at the same Tyr-381 residue in FGFR2 gene. (23808569)
2013
13
A newborn with acanthosis nigricans: can it be Crouzon syndrome with acanthosis nigricans? (20199409)
2010
14
Dandy-Walker malformation in Crouzon syndrome. (20413808)
2010
15
Familial Crouzon syndrome. (22114439)
2010
16
A rare association of acanthosis nigricans with Crouzon syndrome. (20061739)
2010
17
Marathon of eponyms: 3 Crouzon syndrome. (19523096)
2009
18
Early orthodontic management of Crouzon Syndrome: a case report. (23139476)
2009
19
FGFR2 gene mutation in a family with Crouzon syndrome and a sporadic Crouzon syndrome patient]. (18393251)
2008
20
The value of the maxillo-malar osteotomy in the treatment of Crouzon syndrome with exorbitism. (18724129)
2008
21
Endocardial cushion defect in a patient with Crouzon syndrome carrying a mutation in the fibroblast growth factor receptor (FGFR)-2 gene. (17850625)
2007
22
Facial diplegia revealing ventriculoperitoneal shunt failure in a patient with Crouzon syndrome. Case report. (17644920)
2007
23
Crouzon syndrome. (16651211)
2006
24
A cloverleaf skull associated with Crouzon syndrome. (16492963)
2006
25
Intracranial space, brain, and cerebrospinal fluid volume measurements obtained with the aid of three-dimensional computerized tomography in patients with and without Crouzon syndrome. (16238077)
2005
26
Monozygotic twins concordant for Crouzon syndrome. (15669095)
2005
27
Crouzon syndrome: phenotypic signs and symptoms of the postnatally expressed subtype. (15167238)
2004
28
Clinically mild, atypical, and aged craniofacial syndrome is diagnosed as Crouzon syndrome by identification of a point mutation in the fibroblast growth factor receptor 2 gene (FGFR2). (15206560)
2004
29
Mutation analysis of Crouzon syndrome and identification of one novel mutation in Taiwanese patients. (11380921)
2001
30
Abnormal timing in the prenatal ossification of vertebral column and hand in Crouzon syndrome. (10706360)
2000
31
The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. (10696568)
2000
32
Crouzon syndrome with acanthosis nigricans: case report and mutational analysis. (10670894)
2000
33
A novel FGFR2 gene mutation in Crouzon syndrome associated with apparent nonpenetrance. (10574673)
1999
34
Cephalometric analysis of families with dominantly inherited Crouzon syndrome: an aid to diagnosis in family studies. (9632171)
1998
35
Novel mutation in the FGFR2 gene at the same codon as the Crouzon syndrome mutations in a severe Pfeiffer syndrome type 2 case. (9475591)
1998
36
Case report: a surgical and prosthetic approach to combination syndrome presenting in a patient with craniofacial dysostosis (Crouzon syndrome). (9680879)
1998
37
Studies of Crouzon syndrome. (8596806)
1996
38
Jugular foraminal stenosis in Crouzon syndrome. (9309789)
1996
39
Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras. (8755573)
1996
40
Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. (7493034)
1995
41
Constitutive activation of fibroblast growth factor receptor-2 by a point mutation associated with Crouzon syndrome. (7592798)
1995
42
Effect on splicing of a silent FGFR2 mutation in Crouzon syndrome. (7773284)
1995
43
Crouzon syndrome is not linked to craniosynostosis loci at 7p and 5qter. (8014970)
1994
44
Genetic heterogeneity among craniosynostosis syndromes: mapping the Saethre-Chotzen syndrome locus between D7S513 and D7S516 and exclusion of Jackson-Weiss and Crouzon syndrome loci from 7p. (8188211)
1994
45
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. (7874170)
1994
46
Crouzon syndrome: cephalometric analysis and evaluation of pathogenesis. (8068703)
1994
47
Germinal mosaicism in Crouzon syndrome. A family with three affected siblings of normal parents. (1884515)
1991
48
Patterns of dysmorphology in Crouzon syndrome: an anthropometric study. (3168267)
1988
49
Germinal mosaicism in Crouzon syndrome. (3359675)
1988
50
Radiographic hand abnormalities in fifteen cases of Crouzon syndrome. (7166594)
1982

Variations for Crouzon Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Crouzon Syndrome:

67 (show all 37)
id Symbol AA change Variation ID SNP ID
1FGFR2p.Tyr105CysVAR_004112
2FGFR2p.Ser252LeuVAR_004113
3FGFR2p.Ser267ProVAR_004118
4FGFR2p.Phe276ValVAR_004120
5FGFR2p.Cys278PheVAR_004121
6FGFR2p.Gln289ProVAR_004123
7FGFR2p.Trp290ArgVAR_004125
8FGFR2p.Lys292GluVAR_004126
9FGFR2p.Tyr301CysVAR_004127
10FGFR2p.Tyr328CysVAR_004130
11FGFR2p.Asn331IleVAR_004131
12FGFR2p.Gly338GluVAR_004133
13FGFR2p.Tyr340HisVAR_004134
14FGFR2p.Thr341ProVAR_004135
15FGFR2p.Cys342PheVAR_004136
16FGFR2p.Cys342ArgVAR_004137
17FGFR2p.Cys342SerVAR_004138
18FGFR2p.Cys342TyrVAR_004139
19FGFR2p.Ala344GlyVAR_004140
20FGFR2p.Ala344ProVAR_004141
21FGFR2p.Ser347CysVAR_004142
22FGFR2p.Ser351CysVAR_004143
23FGFR2p.Ser354CysVAR_004144
24FGFR2p.Val359PheVAR_004146
25FGFR2p.Gly384ArgVAR_004147
26FGFR2p.Gly338ArgVAR_015011
27FGFR2p.Pro263LeuVAR_017261
28FGFR2p.Cys278TyrVAR_017263
29FGFR2p.Tyr281CysVAR_017264
30FGFR2p.Ile288SerVAR_017265
31FGFR2p.Trp290GlyVAR_017266
32FGFR2p.Ala337ProVAR_017268
33FGFR2p.Cys342TrpVAR_017271
34FGFR2p.Ser354TyrVAR_017272
35FGFR2p.Ala362SerVAR_017273
36FGFR2p.Asn549HisVAR_017276
37FGFR2p.Arg678GlyVAR_017281

Clinvar genetic disease variations for Crouzon Syndrome:

5 (show all 17)
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR2NM_000141.4(FGFR2): c.1025G> A (p.Cys342Tyr)single nucleotide variantPathogenicrs121918487GRCh37Chr 10, 123276892: 123276892
2FGFR2NM_000141.4(FGFR2): c.1018T> C (p.Tyr340His)single nucleotide variantPathogenicrs121918489GRCh37Chr 10, 123276899: 123276899
3FGFR2NM_000141.4(FGFR2): c.1061C> G (p.Ser354Cys)single nucleotide variantPathogenicrs121918490GRCh37Chr 10, 123276856: 123276856
4FGFR2NM_000141.4(FGFR2): c.1024T> C (p.Cys342Arg)single nucleotide variantPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
5FGFR2NM_000141.4(FGFR2): c.1024T> A (p.Cys342Ser)single nucleotide variantPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
6FGFR2NM_000141.4(FGFR2): c.1032G> A (p.Ala344=)single nucleotide variantPathogenicrs121918491GRCh37Chr 10, 123276885: 123276885
7FGFR2NM_000141.4(FGFR2): c.1031C> G (p.Ala344Gly)single nucleotide variantPathogenicrs121918492GRCh37Chr 10, 123276886: 123276886
8FGFR2NM_000141.4(FGFR2): c.983A> G (p.Tyr328Cys)single nucleotide variantPathogenicrs121918493GRCh37Chr 10, 123276934: 123276934
9FGFR2NM_000141.4(FGFR2): c.1040C> G (p.Ser347Cys)single nucleotide variantPathogenicrs121918494GRCh37Chr 10, 123276877: 123276877
10FGFR2NM_000141.4(FGFR2): c.1026C> G (p.Cys342Trp)single nucleotide variantPathogenicrs121918496GRCh37Chr 10, 123276891: 123276891
11FGFR2NM_000141.4(FGFR2): c.866A> C (p.Gln289Pro)single nucleotide variantPathogenicrs121918497GRCh37Chr 10, 123279566: 123279566
12FGFR2NM_000141.4(FGFR2): c.874A> G (p.Lys292Glu)single nucleotide variantPathogenicrs121918500GRCh37Chr 10, 123279558: 123279558
13FGFR2NM_000141.4(FGFR2): c.868T> C (p.Trp290Arg)single nucleotide variantPathogenicrs121918501GRCh37Chr 10, 123279564: 123279564
14FGFR2NM_000141.4(FGFR2): c.868T> G (p.Trp290Gly)single nucleotide variantPathogenicrs121918501GRCh37Chr 10, 123279564: 123279564
15FGFR2NM_000141.4(FGFR2): c.1576A> G (p.Lys526Glu)single nucleotide variantPathogenicrs121918507GRCh37Chr 10, 123258105: 123258105
16FGFR2FGFR2, IVSDS, A-G, +3single nucleotide variantPathogenic
17FGFR2NM_000141.4(FGFR2): c.1009G> C (p.Ala337Pro)single nucleotide variantPathogenicrs387906676GRCh37Chr 10, 123276908: 123276908

Expression for genes affiliated with Crouzon Syndrome

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Search GEO for disease gene expression data for Crouzon Syndrome.

Pathways for genes affiliated with Crouzon Syndrome

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Pathways related to Crouzon Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FGFR1, FGFR2, FGFR3
29.5FGFR1, FGFR2, FGFR3
39.5FGFR1, FGFR2, FGFR3
49.3FGF1, FGFR1, FGFR2
5
Angiogenesis (WikiPathways)
Show member pathways
9.0FGF1, FGFR1, FGFR2
69.0FGF13, FGF2, FGFR1
78.8FGF13, FGF2, TGFB1
8
Show member pathways
8.8FGF13, FGF2, TGFB1
9
Show member pathways
8.5FGF13, FGF2, FGFR2, TGFB1
108.5FGF13, FGF2, FGFR2, TGFB1
118.5FGF13, FGF2, FGFR1, TGFB1
128.5FGF13, FGF2, FGFR1, TGFB1
138.4FGF13, FGF2, FGFR1, FGFR2, FGFR3
14
Show member pathways
8.4FGF13, FGF2, FGFR1, FGFR2, FGFR3
15
Show member pathways
8.4DCN, FGF13, FGF2, TGFB1
16
Show member pathways
8.2FGF1, FGF13, FGF2, FGFR2, FGFR3
17
Show member pathways
8.2FGF1, FGF13, FGF2, FGFR1, FGFR2
188.2FGF13, FGF2, FGFR1, FGFR3, TGFB1
198.0DCN, FGF13, FGF2, FGFR1, TGFB1
208.0FGF13, FGF2, FGFR1, FGFR2, FGFR3, MSX2
217.9FGF1, FGF13, FGF2, FGFR1, TGFB1
22
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
23
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
24
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
25
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
26
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
27
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
28
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
297.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
30
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
317.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
32
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
33
Show member pathways
7.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
347.9FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
35
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
36
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
37
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
387.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
39
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
40
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
41
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
42
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
43
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
44
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
45
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
46
Angiogenesis (CST)
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
477.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
48
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
49
Show member pathways
7.4FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3
50
Show member pathways
6.9DCN, FGF1, FGF13, FGF2, FGFR1, FGFR2

GO Terms for genes affiliated with Crouzon Syndrome

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Cellular components related to Crouzon Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.9DCN, FGF1, FGF13, FGF2, FGFR1, FGFR2

Biological processes related to Crouzon Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idNameGO IDScoreTop Affiliating Genes
1orbitofrontal cortex developmentGO:002176910.6FGFR1, FGFR2
2ventricular zone neuroblast divisionGO:002184710.6FGFR1, FGFR2
3fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.6FGFR1, FGFR2
4positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwayGO:009008010.6FGFR1, FGFR3
5lens fiber cell developmentGO:007030710.5FGFR2, FGFR3
6negative regulation of mitotic nuclear divisionGO:004583910.5FGFR2, FGFR3
7positive regulation of phospholipase C activityGO:001086310.5FGF2, FGFR1
8lung-associated mesenchyme developmentGO:006048410.5FGFR1, FGFR2
9mesenchymal cell differentiationGO:004876210.5FGFR1, FGFR2
10branching involved in salivary gland morphogenesisGO:006044510.5FGFR1, FGFR2
11outflow tract septum morphogenesisGO:000314810.5FGFR2, MSX2
12regulation of endothelial cell chemotaxis to fibroblast growth factorGO:200054410.4FGF1, FGF2
13endochondral bone growthGO:000341610.4FGFR3, MSX2
14negative regulation of blood vessel endothelial cell migrationGO:004353710.3FGF2, TGFB1
15frontal suture morphogenesisGO:006036410.3MSX2, TGFB1
16salivary gland morphogenesisGO:000743510.3FGFR1, TGFB1
17hyaluronan catabolic processGO:003021410.2FGF2, TGFB1
18positive regulation of cardiac muscle cell proliferationGO:006004510.2FGF2, FGFR1, FGFR2
19positive regulation of MAPK cascadeGO:004341010.1FGFR1, FGFR2, FGFR3
20positive regulation of phospholipase activityGO:001051810.1FGFR1, FGFR2, FGFR3
21positive regulation of cell divisionGO:005178110.0FGF1, FGF2, FGFR2
22organ inductionGO:000175910.0FGF1, FGF2, FGFR1
23bone morphogenesisGO:006034910.0FGFR2, FGFR3, MSX2
24peptidyl-tyrosine phosphorylationGO:001810810.0FGFR1, FGFR2, FGFR3
25positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.9FGF2, FGFR3, TGFB1
26organ morphogenesisGO:00098879.9DCN, FGF2, FGFR2
27ureteric bud developmentGO:00016579.9FGFR1, FGFR2, TGFB1
28chondrocyte differentiationGO:00020629.6FGFR1, FGFR3, TGFB1
29angiogenesisGO:00015259.5FGF1, FGF2, FGFR1, FGFR2
30lung developmentGO:00303249.5FGF1, FGF2, FGFR1, FGFR2
31positive regulation of ERK1 and ERK2 cascadeGO:00703749.5FGF1, FGF2, FGFR2, FGFR3
32positive regulation of epithelial cell proliferationGO:00506799.4FGF1, FGF2, FGFR2, TGFB1
33positive regulation of MAP kinase activityGO:00434069.3FGF1, FGF2, FGFR1, TGFB1
34phosphatidylinositol-mediated signalingGO:00480159.3FGF1, FGF2, FGFR1, FGFR2, FGFR3
35negative regulation of cell proliferationGO:00082859.1FGF2, FGFR2, FGFR3, MSX2, TGFB1
36activation of MAPKK activityGO:00001869.1FGF1, FGF2, FGFR1, FGFR2, FGFR3
37Ras protein signal transductionGO:00072659.1FGF1, FGF2, FGFR1, FGFR2, FGFR3
38insulin receptor signaling pathwayGO:00082869.1FGF1, FGF2, FGFR1, FGFR2, FGFR3
39fibroblast growth factor receptor signaling pathwayGO:00085439.1FGF1, FGF2, FGFR1, FGFR2, FGFR3
40Fc-epsilon receptor signaling pathwayGO:00380959.0FGF1, FGF2, FGFR1, FGFR2, FGFR3
41neurotrophin TRK receptor signaling pathwayGO:00480119.0FGF1, FGF2, FGFR1, FGFR2, FGFR3
42wound healingGO:00420609.0DCN, FGF2, MSX2, TGFB1
43axon guidanceGO:00074118.8FGF1, FGF2, FGFR1, FGFR2, FGFR3
44innate immune responseGO:00450878.7FGF1, FGF2, FGFR1, FGFR2, FGFR3
45positive regulation of cell proliferationGO:00082848.7FGF1, FGF2, FGFR1, FGFR2, FGFR3, TGFB1
46vascular endothelial growth factor receptor signaling pathwayGO:00480108.6FGF1, FGF2, FGFR1, FGFR2, FGFR3
47small GTPase mediated signal transductionGO:00072648.4FGF1, FGF2, FGFR1, FGFR2, FGFR3
48epidermal growth factor receptor signaling pathwayGO:00071738.3FGF1, FGF2, FGFR1, FGFR2, FGFR3, TGFB1
49negative regulation of transcription from RNA polymerase II promoterGO:00001228.2ERF, FGFR1, FGFR2, FGFR3, MSX2, TGFB1
50MAPK cascadeGO:00001657.7FGF1, FGF13, FGF2, FGFR1, FGFR2, FGFR3

Molecular functions related to Crouzon Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor bindingGO:000510410.2FGF1, FGF2
2fibroblast growth factor-activated receptor activityGO:000500710.1FGFR1, FGFR2, FGFR3
3fibroblast growth factor bindingGO:001713410.0FGFR1, FGFR2, FGFR3
4protein tyrosine kinase activityGO:00047139.5FGFR1, FGFR2, FGFR3
5heparin bindingGO:00082019.0FGF1, FGF2, FGFR1, FGFR2
6growth factor activityGO:00080838.2FGF1, FGF13, FGF2, TGFB1

Sources for Crouzon Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet