Cryoglobulinemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NIH Rare Diseases:⁴⁸ Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to endocarditis and mesangial proliferative glomerulonephritis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics. The drugs interferon alfa-2b and recombinant interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:¹¹ A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:⁷¹ Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)

id	Related Disease	Score	Top Affiliating Genes
1	endocarditis	29.7	CD40LG, CD79A
2	mesangial proliferative glomerulonephritis	29.5	CD40LG, CD79A
3	homocystinuria	29.5	CD40LG, CD79A
4	cryoglobulinemia, familial mixed	12.2
5	type ii mixed cryoglobulinemia	11.9
6	mixed cryoglobulinemia type iii	11.9
7	simple cryoglobulinemia	11.8
8	hepatitis c virus	11.3
9	hepatitis	10.7
10	hepatitis c	10.7
11	vasculitis	10.4
12	primary laryngeal lymphangioma	10.3	CXCL10, CXCL11
13	amyotrohpic lateral sclerosis type 22	10.3	CD40LG, CXCL10
14	paramyloidosis	10.3	CD40LG, CD5
15	hyperparathyroidism, primary, caused by water clear cell hyperplasia	10.3	CD40LG, TNFSF13B
16	dyskeratosis congenita	10.3	CD40LG, CXCL10
17	alcoholic neuropathy	10.3	CD40LG, CD79A
18	camptodactyly vertebral fusion	10.3	CD40LG, CD79A
19	spinal polio	10.3	CD40LG, CD79A
20	rabies	10.3	CD40LG, CD79A
21	unilateral retinoblastoma	10.3	CD40LG, CD79A
22	delta chain disease	10.3	CD40LG, CD79A
23	discitis	10.3	CD40LG, CD79A
24	spinal canal and spinal cord meningioma	10.3	CD40LG, CD79A
25	trichostrongyloidiasis	10.3	CD40LG, CD79A
26	colloid adenoma	10.2	CD40LG, CD79A
27	heart septal defect	10.2	CD40LG, CD79A
28	cutaneous polyarteritis nodosa	10.2	CD40LG, CD79A
29	lymphoma	10.2
30	mild pre-eclampsia	10.2	CD40LG, CD79A
31	retinal microaneurysm	10.2	CD40LG, CD79A
32	pediatric meningioma	10.2	CD40LG, CD79A
33	tonsil cancer	10.2	CD40LG, CD79A
34	indomethacin antenatal infection	10.2	CD40LG, CD79A
35	postcricoid region cancer	10.2	CD40LG, CD79A
36	beach ear	10.2	CD40LG, CD79A
37	acute kidney tubular necrosis	10.2	CD40LG, CD79A
38	atheroembolism of kidney	10.2	CD40LG, CD79A
39	partial sensory epilepsy	10.2	CD40LG, CD79A
40	ritscher-schinzel syndrome 1	10.2	CD40LG, CD79A
41	diabetic angiopathy	10.2	CD40LG, CD79A
42	muscular dystrophy	10.2	CD40LG, CD79A
43	dumping syndrome	10.2	CD40LG, CD79A
44	striatonigral degeneration	10.2	CD40LG, CD79A
45	ciliary body spindle cell melanoma	10.2	CD40LG, CD79A
46	purulent endophthalmitis	10.2	CD40LG, CD79A
47	mu chain disease	10.2	CD40LG, CD79A
48	generalized atherosclerosis	10.2	CD40LG, CD79A
49	bursitis	10.2	CD40LG, CD79A
50	syphilis	10.2	CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:

Symptoms & Phenotypes for Cryoglobulinemia

Sources:
⁴¹MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	6.8	CD27, CD40LG, CD5, CD79A, CD81, CR2
2	immune system	MP:0005387	6.0	CD27, CD40LG, CD5, CD79A, CD81, CR2

Drugs & Therapeutics for Cryoglobulinemia

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁴⁶NDF-RT, ⁵⁰Novoseek, ⁵⁶PharmGKB, ⁶⁸UMLS
See all MalaCards sources

Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

rituximab

approved

Phase 4, Phase 2, Phase 3

1692

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

MabThera

Mabthera

Rituxan

rituximab

2

Antirheumatic Agents

Phase 4, Phase 2, Phase 3

10956

3

Sofosbuvir

approved

Phase 2, Phase 3

259

1190307-88-0

45375808

Synonyms:

S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate

SOVALDI

4

Ledipasvir

approved

Phase 2, Phase 3

107

1256388-51-8

67505836

Synonyms:

methyl [(2S)-1-{(6S)-6-[4-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

5

Antiviral Agents

Phase 2, Phase 3, Phase 1

9967

6

Anti-Infective Agents

Phase 2, Phase 3, Phase 1

22062

7

Ledipasvir, sofosbuvir drug combination

Phase 2, Phase 3

56

8

Aldesleukin

approved

Phase 1, Phase 2

405

85898-30-2, 110942-02-4

Synonyms:

125-L-serine-2-133-interleukin 2 (human reduced)

Interleukin-2 aldesleukin

Interleukin-2(2-133),125-ser

Recombinant interleukin-2 human

9

Prednisone

approved, vet_approved

Phase 2

1398

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

ACon0_000082

ACon1_000297

AI3-52939

Adasone

Ancortone

Apo-Prednisone

Apo-prednisone

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

Betapar

Bicortone

Bio-0649

C07370

C21H26O5

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

CPD001227202

Cartancyl

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

DB00635

Dacorten

Dacortin

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

Delta Cortelan

Delta E

Delta E.

Delta-Cortelan

Delta-Dome

Delta-cortelan

Delta-cortisone

Delta-cortone

Delta-dome

Deltacortene

Deltacortisone

Deltacortone

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Di-Adreson

Diadreson

EINECS 200-160-3

Econosone

Encorton

Encortone

Enkortolon

Enkorton

Fernisone

Fiasone

HMS1568O15

HMS2090J13

HSDB 3168

Hostacortin

In-Sone

Incocortyl

Juvason

Kortancyl

LMST02030180

LS-1325

Liquid Pred

Lisacort

Lodotra

MEGxm0_000443

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

Me-Korti

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI-C04897

NCI60_000008

NSC 10023

NSC10023

Nisona

Nizon

Novoprednisone

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

PRD

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Precort

Predeltin

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Prednison

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone Intensol

Prednisone [INN:BAN]

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Prestwick_405

Pronison

Pronisone

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

SK-Prednisone

SMR000718760

SMR001227202

SPBio_002214

Servisone

Sone

Sterapred

Supercortil

U 6020

UNII-VB0R961HZT

Ultracorten

Ultracortene

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Winpred

Wojtab

ZINC03875357

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

delta cortelan

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

delta-Cortisone

delta-Cortone

10

s 1 (combination)

Phase 1, Phase 2

378

Synonyms:

Gimeracil / oteracil / tegafur

TS 1

11

Analgesics

Phase 1, Phase 2

11733

12

Peripheral Nervous System Agents

Phase 1, Phase 2

23689

13

Interleukin-2

Phase 1, Phase 2

571

14

Analgesics, Non-Narcotic

Phase 1, Phase 2

6501

15

Immunoglobulins

Phase 2

6394

16

Antibodies, Monoclonal

Phase 2

4039

17

Anti-Retroviral Agents

Phase 1, Phase 2

3296

18

Antibodies

Phase 2

6394

19

Anti-HIV Agents

Phase 1, Phase 2

3162

20

Lactitol

Phase 1, Phase 2

336

585-86-4

3871

Synonyms:

4-O-b-D-Galactopyranosyl-D-glucitol, 9CI

E966

Emportal

Floralac

Importal

Oponaf

Portolac

21

Hormones

Phase 2

14415

22

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2

13168

23

Hormone Antagonists

Phase 2

13180

24

glucocorticoids

Phase 2

5103

25

Anti-Inflammatory Agents

Phase 2

10729

26

Antineoplastic Agents, Hormonal

Phase 2

5592

27

Ribavirin

approved

1003

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

28

Liver Extracts

4067

29

interferons

2175

Interventional clinical trials:

(show all 16)

id	Name	Status	NCT ID	Phase
1	Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab	Completed	NCT00820469	Phase 4
2	Tolerance and Efficacy of Rituximab in Sjogren's Disease	Completed	NCT00740948	Phase 2, Phase 3
3	Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia	Recruiting	NCT02825212	Phase 2, Phase 3
4	Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata	Unknown status	NCT01840046	Phase 1, Phase 2
5	Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients	Completed	NCT00574652	Phase 1, Phase 2
6	Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic Vasculitis	Completed	NCT00029107	Phase 2
7	Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis	Recruiting	NCT02556866	Phase 2
8	Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting	Unknown status	NCT01932021
9	Characterization of Clonal B Cell Populations in HCV Infection	Completed	NCT00435201
10	The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders	Completed	NCT00960713
11	Hepatitis C Virus and the Humoral Immune System	Completed	NCT00219999
12	Impact of Vasculitis on Employment and Income	Completed	NCT02476292
13	Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis	Recruiting	NCT02856243
14	Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment	Recruiting	NCT03042520
15	Clinical Transcriptomics in Systemic Vasculitis (CUTIS)	Recruiting	NCT03004326
16	Vasculitis Pregnancy Registry	Recruiting	NCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS⁶⁸/NDF-RT⁴⁶:

interferon alfa-2a

interferon alfa-2b

interferon alfa-3n,human leukocyte derived

interferon alfacon-1

interferon gamma-1b

interferons

peginterferon alfa-2a

peginterferon alfa-2b

recombinant interferon beta-1a

recombinant interferon beta-1b

Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

Anatomical Context for Cryoglobulinemia

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Cryoglobulinemia:

³⁶

B cells, Skin, Liver, Kidney, Thyroid, Bone, Brain

Publications for Cryoglobulinemia

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Cryoglobulinemia:

(show top 50) (show all 840)

id	Title	Authors	Year
1	Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. (27666584)	Emmanuel B.... Kottilil S.	2017
2	How I treat cryoglobulinemia. (27799164)	Muchtar E.... Gertz M.A.	2017
3	Micro and nanoparticles as possible pathogenetic co-factors in mixed cryoglobulinemia. (27694373)	Artoni E.... Ferri C.	2017
4	MACULAR PERIVENOUS RETINAL WHITENING AND PRESUMED RETINO-CILIARY SPARING IN A RECURRENT CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH THE ANTIPHOSPHOLIPID SYNDROME AND CRYOGLOBULINEMIA. (27902540)	Sebrow D.B.... Freund K.B.	2016
5	A systemic lupus erythematosus patient presenting as type B insulin resistance complicated with cryoglobulinemia. (27416845)	Huang Q.... Zuo L.	2016
6	Incidence of thyroid disorders in mixed cryoglobulinemia: Results from a longitudinal follow-up. (26970485)	Fallahi P.... Antonelli A.	2016
7	Digital ischemic necrosis with cryoglobulinemia associated with hepatitis B infection. (27857479)	Arslan F.... Mert A.	2016
8	Hepatic and Mesenteric Vasculitis as Presenting Manifestation of Mixed Cryoglobulinemia Related to Chronic Hepatitis C Virus Infection in a Female Patient. (27219310)	Calle Toro J.S.... Tobon G.	2016
9	Successful ledipasvira88+a88sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. (27848256)	Koga T.... Kawakami A.	2016
10	Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study. (27161362)	Roccatello D.... Menegatti E.	2016
11	Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study. (26853322)	Gragnani L.... Zignego A.L.	2016
12	Clinical and Morphologic Spectrum of Renal Involvement in Patients with HBV-Associated Cryoglobulinemia. (27062412)	Li S.J.... Liu Z.H.	2016
13	Coronary artery bypass grafting in a patient with active idiopathic cryoglobulinemia: revisiting the issue. (26908383)	Fakih H.A.... Vij R.	2016
14	Cryoglobulinemia in a patient with chronic lymphocytic leukemia - A case report and review of literature of renal involvement in CLL. (27519936)	Arora S.... Braverman A.	2016
15	Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. (27672862)	Patel A.	2016
16	Successful Treatment of Pyoderma Gangrenosum with Cryoglobulinemia and Hepatitis C. (27345376)	Pourmorteza M.... Young M.	2016
17	Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia. (27483451)	Gragnani L.... Zignego A.L.	2016
18	HCV-associated cryoglobulinemia vasculitis: are its days numbered? (27797754)	Moiseev S.... Mukhin N.	2016
19	Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia. (27139837)	Cusato J.... D'Avolio A.	2016
20	An Unusual Case of HCV Negative Cryoglobulinemia Presenting as Symmetrical Peripheral Gangrene. (27190872)	Dalai S.P.... Tripathy S.K.	2016
21	A Rare Cause of Unilateral Central Retinal Vein Occlusion in a Young Patient: Type III Mixed Cryoglobulinemia. (27418988)	Doguizi S.... Yilmazbas P.	2016
22	Purtscher-like Retinopathy as a Rare Presentation of Cryoglobulinemia. (27162457)	Chebil A.... El Matri L.	2016
23	The possible persistence of mixed cryoglobulinemia stigmata in spite of viral eradication: Insufficient or too late antiviral treatment? (27943334)	Zignego A.L.... Casato M.	2016
24	Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia. (27403724)	Ogishi M.... Koike K.	2016
25	Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. (26785421)	de Lorenzo-Pinto A.... Pinilla Llorente B.	2016
26	Unique Renal Manifestation of Type I Cryoglobulinemia, With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells. (26796493)	Hoelbeek J.... Florquin S.	2016
27	The correlation between antiphospholipid syndrome and cryoglobulinemia: case series of 4 patients and review of the literature. (27267327)	Shachaf S.... Yair M.	2016
28	Refractory Mononeuritis Multiplex Due to Hepatitis C Infection and Cryoglobulinemia: Efficient Response to Rituximab. (27119277)	Soares C.N.	2016
29	Virologic, Clinical, and Immune Response Outcomes of Patients With Hepatitis C Virus-Associated Cryoglobulinemia Treated With Direct-Acting Antivirals. (27725289)	Bonacci M.... HernA!ndez-RodrA-guez J.	2016
30	Mixed cryoglobulinemia-associated SjAPgren's syndrome leading to spontaneous rupture of the kidney: a case report. (27042145)	Haddiya I.... Bayahia R.	2016
31	Annular leukocytoclastic vasculitis associated with essential mixed cryoglobulinemia. (27098553)	Matsuzaki Y.... Sawamura D.	2016
32	Cold-associated painful purple digits due to type I cryoglobulinemia. (27681488)	Suyama Y.... Okada M.	2016
33	Lymphoproliferative associated type 1 cryoglobulinemia. (26271811)	Martens P.J.... Delforge M.	2015
34	Cryoglobulinemia presenting with crystals in peripheral blood. (26966746)	Chan N.C.... Tang S.S.	2015
35	Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment. (26060059)	Boglione L.... D'Avolio A.	2015
36	Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)	Ayad M.W.... Sakr A.S.	2015
37	Successful treatment of HCV-associated cryoglobulinemia with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin: A case report. (26414149)	Makara M.... VA!lyi-Nagy I.	2015
38	Glomerulonephritis and cryoglobulinemia: first manifestation of visceral leishmaniasis. (25600859)	Ortiz M.... Blanco J.	2015
39	Recurrent Mixed Cryoglobulinemia (MCS): A Case Report and Literature Review. (26422544)	Bhattarai M.... Bernardo J.F.	2015
40	Early onset mixed cryoglobulinemia in hepatitis C. (26275272)	Krishnamurthy K.... Jha N.	2015
41	Cryoglobulinemia in a Tunisian internal medicine department. (26039888)	Boukhris I.... Kooli C.	2015
42	Abnormal CD4a88+a88T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection. (26129991)	Kong F.... Wei L.	2015
43	Cryofibrinogenemia: a marker of severity of cryoglobulinemia vasculitis. (25827358)	Michaud M.... Sailler L.	2015
44	Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review. (26031898)	Visentini M.... Casato M.	2015
45	Cryoglobulinemia Vasculitis. (25837517)	Cacoub P.... Saadoun D.	2015
46	1259: CRYOGLOBULINEMIA DUE TO HEPATITIS C LEADING TO LIFE-THREATENING PULMONARY ALVEOLAR HEMORRHAGE. (26570920)	Chandrasekar V.T.... Kohlitz P.	2015
47	Cryoglobulinemia precipitated by targeted temperature management. (25605473)	Molinero C.... Argaud L.	2015
48	The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. (25452118)	Aihara N.... Shirota K.	2015
49	Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents. (26474537)	Sise M.E.... Chung R.T.	2015
50	Role of CXCL10 in cryoglobulinemia. (25571936)	Mazzi V.... Fallahi P.	2015

Genes related to Cryoglobulinemia

Sources:
¹³DISEASES, ²¹GeneCards, ⁵⁰Novoseek
See all MalaCards sources

Genes related to Cryoglobulinemia:

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	CD40LG	CD40 Ligand	43.36	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	11875606, 8600660, 2074925 more 16797380, 11769562
2	IFNA2	Interferon Alpha 2	39.38	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	8955758, 9252075, 8832526
3	TSLP	Thymic Stromal Lymphopoietin	39.17	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	17322382
4	CD79A	CD79a Molecule	38.73	DISEASES inferred ¹³ Novoseek inferred ⁵⁰ GeneCards inferred via : Disorders, Publications (show sections)	10380044, 11875606, 1300443
5	CXCL10	C-X-C Motif Chemokine Ligand 10	33.38	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
6	CD5	CD5 Molecule	32.97	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
7	CD81	CD81 Molecule	32.70	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
8	TNFSF13B	TNF Superfamily Member 13b	32.30	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
9	CD27	CD27 Molecule	32.01	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
10	CR2	Complement C3d Receptor 2	31.72	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
11	IFNL3	Interferon Lambda 3	31.72	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
12	CXCL11	C-X-C Motif Chemokine Ligand 11	31.46	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)

Variations for Cryoglobulinemia

Expression for genes affiliated with Cryoglobulinemia

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁶PharmGKB, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 11)

id	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁹	9.5	CD5, CD79A, IFNA2
2	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics⁵⁶ Show member pathways Inhibition of PKR⁶⁰	9.4	IFNA2, IFNL3
3	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions⁵⁹ Show member pathways TNFs bind their physiological receptors⁶⁰	9.2	CD27, CD40LG, TNFSF13B
4	IgA-Producing B Cells in the Intestine⁵⁹	9.1	CD40LG, CR2, TNFSF13B
5	NF-kappaB Signaling³	9.1	CD40LG, CD79A, CXCL10, TNFSF13B
6	Jak-STAT signaling pathway (KEGG)³⁴ Show member pathways Jak-STAT signaling pathway³⁴ Interleukin-19, 20, 22, 24⁶⁰ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁹ B-Cell Development⁵⁸	9.1	IFNA2, IFNL3, TSLP
7	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ Graft-versus-host disease³⁴ Antigen processing and presentation³⁴ THC Differentiation Pathway⁵⁸	8.9	CD40LG, CXCL11, IFNA2, TNFSF13B
8	G-protein signaling_RhoB regulation pathway⁶⁵	8.9	CD40LG, CXCL10, CXCL11, TNFSF13B
9	B Cell Development Pathways⁵⁹	8.7	CD27, CD40LG, CD5, CR2
10	Cytokine Signaling in Immune system⁶⁰ Show member pathways Signaling by Interleukins⁶⁰	7.8	CD27, CD40LG, CXCL10, IFNA2, IFNL3, TNFSF13B
11	PEDF Induced Signaling⁵⁸ Show member pathways Glucocorticoid Receptor Signaling⁵⁸ Endothelin-1 Signaling Pathway⁵⁸ Cytokine-cytokine receptor interaction³⁴ IL-6 Pathway⁵⁸ STAT3 Pathway⁵⁸ PGC1Alpha Pathway⁵⁸ all-trans-Retinoic Acid Signaling in Brain⁵⁸ MIF Regulation of Innate Immune Cells⁵⁸ NFAT Signaling and Lymphocyte Interactions⁵⁸ RAR-Gamma-RXR-Alpha Degradation⁵⁸ MIF Mediated Glucocorticoid Regulation⁵⁸	7.0	CD27, CD40LG, CXCL10, CXCL11, IFNA2, IFNL3

GO Terms for genes affiliated with Cryoglobulinemia

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.4	CD27, CD40LG, CD5, CD79A, CXCL10
2	extracellular region	GO:0005576	7.7	CD27, CD40LG, CXCL10, CXCL11, IFNA2, IFNL3
3	extracellular space	GO:0005615	7.5	CD40LG, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	immunoglobulin secretion	GO:0048305	10.4	CD40LG, TNFSF13B
2	positive regulation of cAMP metabolic process	GO:0030816	10.3	CXCL10, CXCL11
3	positive regulation of cAMP-mediated signaling	GO:0043950	10.3	CXCL10, CXCL11
4	positive regulation of release of sequestered calcium ion into cytosol	GO:0051281	10.2	CXCL10, CXCL11
5	T cell chemotaxis	GO:0010818	10.2	CXCL10, CXCL11
6	defense response	GO:0006952	10.0	CXCL10, CXCL11, IFNA2
7	T cell costimulation	GO:0031295	9.9	CD40LG, CD5, TNFSF13B
8	defense response to virus	GO:0051607	9.7	CXCL10, IFNA2, IFNL3
9	B cell differentiation	GO:0030183	9.7	CD40LG, CD79A, CR2, IFNA2
10	B cell proliferation	GO:0042100	9.7	CD40LG, CD79A, CR2, IFNA2
11	response to lipopolysaccharide	GO:0032496	9.7	CD27, CXCL10, CXCL11
12	cell surface receptor signaling pathway	GO:0007166	9.3	CD27, CD79A, CD81, CXCL10, IFNA2
13	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.2	CD27, CD40LG, TNFSF13B
14	inflammatory response	GO:0006954	9.2	CD27, CD40LG, CXCL10, CXCL11, IFNA2
15	immune response	GO:0006955	8.4	CD27, CD40LG, CR2, CXCL10, CXCL11, TNFSF13B

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	CXCR3 chemokine receptor binding	GO:0048248	10.3	CXCL10, CXCL11
2	tumor necrosis factor receptor binding	GO:0005164	9.8	CD40LG, TNFSF13B
3	transmembrane signaling receptor activity	GO:0004888	9.0	CD27, CD5, CD79A, CR2
4	cytokine activity	GO:0005125	8.1	CD40LG, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B