MCID: CRY004
MIFTS: 49

Cryoglobulinemia malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

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Aliases & Descriptions for Cryoglobulinemia:

Name: Cryoglobulinemia 10 45 47 12 36 65
 
Cryoimmunoglobulinaemia 10

Classifications:



External Ids:

Disease Ontology10 DOID:2917
ICD1027 D89.1
SNOMED-CT59 30911005
MeSH36 D003449
NCIt42 C26736
UMLS65 C0010403

Summaries for Cryoglobulinemia

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NIH Rare Diseases:45 Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to purpura and proliferative glomerulonephritis, and has symptoms including vasculitic rashand cryoglobulinemic purpura. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Inflammatory Response Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:10 A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:68 Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1purpura30.9CD40LG, CD79A
2proliferative glomerulonephritis30.7CD40LG, CD79A
3pemphigus30.2CD40LG, CD79A
4blue toe syndrome30.0CD40LG, CD79A
5complex regional pain syndrome29.4CD27, IFNA2
6viral hepatitis29.4CD81, CXCL10, IFNA2
7pneumocystosis29.4CD27, CD40LG, CD79A
8systemic lupus erythematosus28.8CD40LG, CD79A, CR2, CXCL10, TNFSF13B
9familial mixed cryoglobulinemia12.1
10type ii mixed cryoglobulinemia12.0
11mixed cryoglobulinemia type iii12.0
12simple cryoglobulinemia11.9
13cryoglobulinemic vasculitis11.7
14hepatitis c virus11.1
15rare endometriosis10.8CXCL10, CXCL11
16hepatitis10.8
17hepatitis c10.8
18rickettsia parkeri spotted fever10.7CD40LG, CXCL10
19typhus10.6CD40LG, CD79A
20pulmonary edema10.6CD40LG, CD79A
21congenital hypogammaglobulinemia10.6CD40LG, CD79A
22calabro syndrome10.6CD40LG, CD79A
23gamma heavy chain disease10.6CD40LG, CD79A
24exanthema subitum10.6CD40LG, CD79A
25osteomalacia10.6CD40LG, CD79A
26epidermolysis bullosa simplex10.6CD40LG, CD79A
27acute salpingitis10.6CD40LG, CD79A
28beriberi10.6CD40LG, CD79A
29cystitis10.6CD40LG, CD79A
30choroid plexus meningioma10.6CD40LG, CD79A
31immunotactoid glomerulopathy10.6CD40LG, CD79A
32subacute delirium10.6CD40LG, CD79A
33chronic hiccups10.6CD79A, TNFSF13B
34alpha chain disease10.6CD40LG, CD79A
35dysgammaglobulinemia10.6CD40LG, CD79A
36generalized atherosclerosis10.6CD40LG, CD79A
37central sleep apnea10.6CD40LG, CD79A
38sialadenitis10.6CD40LG, CD79A
39ureteral lymphoma10.6CD40LG, CD79A
40mixed lacrimal gland cancer10.6CD40LG, CD79A
41somatoform disorder10.6CD40LG, CD79A
42duodenal benign neoplasm10.6CD79A, CXCL10
43aids phobia10.6CD40LG, CD79A
44ocular hypotension10.6CD40LG, CD79A
45tenosynovitis10.6CD40LG, CD79A
46hyperostosis10.6CD40LG, IFNA2
47brucella melitensis brucellosis10.6CD40LG, CD79A
48fallopian tube carcinoma10.6CD40LG, CD79A
49maxillary sinusitis10.6CD40LG, CD79A
50plasma protein metabolism disease10.6CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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UMLS symptoms related to Cryoglobulinemia:


vasculitic rash, cryoglobulinemic purpura

Drugs & Therapeutics for Cryoglobulinemia

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Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 4, Phase 2, Phase 31582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 4, Phase 2, Phase 38496
3Immunologic FactorsPhase 4, Phase 2, Phase 318483
4
AldesleukinapprovedPhase 1, Phase 238785898-30-2
Synonyms:
IL-2
Interleukin-2 precursor
 
Proleukin
T-cell growth factor
TCGF
5
PrednisoneapprovedPhase 2126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
6ImmunoglobulinsPhase 24477
7Antibodies, MonoclonalPhase 22413
8AntibodiesPhase 24477
9
LactitolPhase 1, Phase 2320585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
10AnalgesicsPhase 1, Phase 29358
11Analgesics, Non-NarcoticPhase 1, Phase 25184
12Interleukin-2Phase 1, Phase 2487
13
s 1 (combination)Phase 1, Phase 2325
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
14Peripheral Nervous System AgentsPhase 1, Phase 218510
15glucocorticoidsPhase 23896
16Anti-Inflammatory AgentsPhase 28478
17Antineoplastic Agents, HormonalPhase 24256
18Hormone AntagonistsPhase 210002
19Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
20HormonesPhase 211748
21Liver Extracts3572

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Study of the Influence of Plasma Exchange on the Pharmacokinetics of RituximabCompletedNCT00820469Phase 4
2Tolerance and Efficacy of Rituximab in Sjogren's DiseaseCompletedNCT00740948Phase 2, Phase 3
3Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis PatientsCompletedNCT00574652Phase 1, Phase 2
4Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2
5Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia VasculitisRecruitingNCT02556866Phase 2
6Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia AreataRecruitingNCT01840046Phase 1, Phase 2
7The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune DisordersCompletedNCT00960713
8Hepatitis C Virus and the Humoral Immune SystemCompletedNCT00219999
9Characterization of Clonal B Cell Populations in HCV InfectionCompletedNCT00435201
10Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
11Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingRecruitingNCT01932021
12Vasculitis Pregnancy RegistryRecruitingNCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

33
B cells, Skin, Liver, Breast, Kidney, Bone, Thyroid

Animal Models for Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Cryoglobulinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.3CD27, CD40LG, CD5, CD79A, CD81, CR2
2MP:00053876.0CD27, CD40LG, CD5, CD79A, CD81, CR2

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 823)
idTitleAuthorsYear
1
Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. (26785421)
2016
2
Pulmonary hemorrhage in cryoglobulinemia. (25493699)
2015
3
Influence of HCV and HIV on Development of Cryoglobulinemia. (25723551)
2015
4
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)
2015
5
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
6
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
7
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
8
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
9
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
10
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
11
Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)
2010
12
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
13
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
14
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
15
Cryoglobulinemia and renal disease. (18408474)
2008
16
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
17
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
18
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)
2008
19
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
20
Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)
2007
21
Cryoglobulinemia. (17289231)
2007
22
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
23
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
24
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
25
Images in clinical medicine. Mixed cryoglobulinemia. (15972869)
2005
26
Autoamputation in a patient with cryoglobulinemia. (15468383)
2004
27
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
28
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
29
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
30
Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)
2000
31
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
32
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
33
Cryoglobulinemia. (10626153)
1999
34
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
35
Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)
1995
36
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
37
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
38
The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)
1994
39
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
40
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
41
Cryoglobulinemia type II]. (2074925)
1990
42
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
43
Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)
1986
44
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
45
Synovial fluid in mixed cryoglobulinemia. (737009)
1978
46
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978
47
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
48
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
49
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956
50

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7CD40LG, FN1
29.4CD5, CD79A, IFNA2
39.2CD40LG, CR2, TNFSF13B
4
Show member pathways
8.9CD40LG, CD79A, CD81, CR2
5
Show member pathways
8.8CXCL10, CXCL11, FN1
6
Show member pathways
8.7CD5, CD79A, CD81, CR2
78.6CD27, CD40LG, CD5, CR2
8
Show member pathways
7.5CD27, CD40LG, CXCL10, CXCL11, IFNA2, TNFSF13B
9
Show member pathways
7.5CD27, CD40LG, CD79A, CD81, CXCL10, FN1

GO Terms for genes affiliated with Cryoglobulinemia

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Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1T cell chemotaxisGO:00108189.6CXCL10, CXCL11
2positive regulation of cAMP-mediated signalingGO:00439509.5CXCL10, CXCL11
3inflammatory responseGO:00069549.5CD27, CXCL10, IFNA2
4cell-cell signalingGO:00072679.2CXCL10, CXCL11, IFNA2
5cell surface receptor signaling pathwayGO:00071669.2CD27, CD81, CXCL10, IFNA2
6response to lipopolysaccharideGO:00324968.8CD27, CXCL10, CXCL11
7immune responseGO:00069557.8CD27, CR2, CXCL10, CXCL11, TNFSF13B

Sources for Cryoglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet