MCID: CRY004
MIFTS: 59

Cryoglobulinemia malady

Rare diseases, Immune diseases categories
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Summaries for Cryoglobulinemia

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NIH Rare Diseases:42 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis c and glomerulonephritis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Antigen Activates B Cell Receptor Leading to Generation of Second Messengers. The drugs interferon alfa-2a and interferon alfa-2b and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:65 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

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Cryoglobulinemia, Aliases & Descriptions:

Name: Cryoglobulinemia 8 42 10 44 62
 
Cryoimmunoglobulinaemia 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:2917
MeSH34 D003449
SNOMED-CT57 30911005
NCIt39 C26736

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.8CD40LG, IFNA2
2glomerulonephritis31.1CD40LG, CD79A, TSLP
3purpura31.1CD79A
4membranoproliferative glomerulonephritis30.9TSLP, IFNA2, CD79A
5macroglobulinemia30.8CD79A, CD5
6q fever30.7CD79A
7chronic lymphocytic leukemia30.6CD5, IGHM
8polyarteritis nodosa30.5IFNA2
9hepatitis b30.5CD79A, IFNA2, IGHM
10b-cell lymphomas30.4CD5, BCR, IGHM
11vasculitis30.4IGHM, APOH, IFNA2, CD79A, CD40LG
12viral hepatitis30.4IFNA2
13malt lymphoma30.3IGHM, CD5
14retinal vasculitis30.2APOH
15lupus erythematosus30.2APOH, CD79A, CD40LG
16polyneuropathy30.2CD40LG, CD79A, IFNA2
17hairy cell leukemia30.2CD5, IFNA2
18macroglobulinemia, waldenstrom, somatic30.1IGHM, CD40LG
19myeloma30.0IGHM, IFNA2, BCR, CD79A, CD40LG
20leukemia30.0IFNA2, BCR, CD5, CD79A, CD40LG
21antiphospholipid syndrome29.7CD40LG, CD79A, APOH
22nephritis29.7CD40LG, CD79A, APOH
23cryoglobulinemic vasculitis29.7IGHM, TSLP, IFNA2, BCR, CD5, CD40LG
24thrombocytopenia29.6CD40LG, CD79A, IFNA2, APOH
25systemic lupus erythematosus29.5CD40LG, CD79A, BCR, APOH, IGHM
26rheumatoid arthritis29.5IGHM, APOH, CD5, CD79A, CD40LG
27hepatitis11.1
28hepatitis c virus11.0
29type ii mixed cryoglobulinemia10.7
30neuropathy10.5
31dysentery10.4CD79A
32chickenpox10.4CD79A
33agammaglobulinemia 310.4CD79A
34mumps10.4CD79A
35cryptosporidiosis10.4CD79A
36peripheral neuropathy10.4
37hodgkin's lymphoma10.4
38multiple myeloma10.4
39thyroiditis10.3
40liver disease10.3
41degos disease10.3APOH
42congenital toxoplasmosis10.3CD40LG, CD79A
43arthritis10.3
44immunoglobulin g deficiency10.3CD40LG, CD79A
45selective iga deficiency disease10.3CD79A, CD40LG
46immunodeficiency, centromere instability and facial anomalies syndrome10.3CD40LG, CD79A
47immunoglobulin alpha deficiency10.3CD79A, CD40LG
48immunodeficiency with hyper igm type 110.3CD40LG, CD79A
49rubella10.3CD79A, CD40LG
50autoimmune thyroiditis10.3

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

32
Skin, B cells, Liver, Kidney, Thyroid, Bone, Brain, Bone marrow, T cells, Endothelial, Neutrophil, Lymph node, Lung, Testes, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Monocytes, Nk cells

Animal Models for Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Cryoglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5BCR, CD79A, CD40LG, IGHM
2MP:00053977.7IGHM, TSLP, BCR, CD5, CD79A, CD40LG
3MP:00053877.6IGHM, TSLP, BCR, CD5, CD79A, CD40LG
4MP:00053767.0CD79A, BCR, TSLP, APOH, IGHM, CD40LG

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 765)
idTitleAuthorsYear
1
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
2
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
3
The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)
2011
4
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
5
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
6
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
7
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
8
Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)
2010
9
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
10
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
11
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
12
Cryoglobulinemia and renal disease. (18408474)
2008
13
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
14
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
15
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)
2008
16
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
17
Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)
2007
18
Cryoglobulinemia. (17289231)
2007
19
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
20
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
21
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
22
Images in clinical medicine. Mixed cryoglobulinemia. (15972869)
2005
23
Successful treatment of necrotizing vasculitic lesions after infusion of iloprost in a patient with cryoglobulinemia and chronic HCV infection. (16396716)
2005
24
Autoamputation in a patient with cryoglobulinemia. (15468383)
2004
25
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
26
HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)
2003
27
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
28
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
29
Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)
2000
30
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
31
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
32
Cryoglobulinemia. (10626153)
1999
33
Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)
1999
34
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
35
Exacerbation of peripheral neuropathy during alpha-interferon therapy in a patient with mixed cryoglobulinemia and hepatitis B virus infection. (8877939)
1996
36
Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)
1995
37
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
38
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
39
The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)
1994
40
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
41
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
42
Cryoglobulinemia type II]. (2074925)
1990
43
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
44
Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)
1986
45
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
46
Synovial fluid in mixed cryoglobulinemia. (737009)
1978
47
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978
48
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
49
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, CD79A
2
Show member pathways
9.3CD79A, IGHM
38.9CD79A, CD5, IGHM

Compounds for genes affiliated with Cryoglobulinemia

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Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4410.0CD79A, CD40LG
2sandoglobulin4410.0CD40LG, CD79A
3vancomycin44 1111.0CD40LG, CD79A
4pneumococcal4410.0CD79A, CD40LG
5tuberculin4410.0CD40LG, CD79A
6chlorambucil44 1111.0CD40LG, IFNA2
7praziquantel44 1111.0CD40LG, CD79A
8hemocyanin4410.0CD40LG, CD79A
9fluorochrome449.9BCR, CD40LG
10gliadin449.9CD79A, CD40LG
11mizoribine449.9IFNA2, CD79A
12pmma449.9CD40LG, CD79A
13silicone449.9CD40LG, CD79A
14busulfan44 50 1111.8BCR, IFNA2
15mannan449.8CD79A, CD40LG
16isotretinoin44 1110.7IFNA2, CD79A
17allergens449.7TSLP, CD40LG, CD79A
18dapsone44 2 50 1112.6CD79A, IFNA2
19okt3449.6CD40LG, CD79A
20gamma globulin449.6CD79A, CD40LG, IFNA2
21neopterin449.6CD40LG, CD79A, IFNA2
22polyethylene glycol449.6IFNA2, CD40LG, CD79A
23thyroxine44 2410.5CD40LG, CD79A, IFNA2
24blys449.5CD79A, BCR, CD40LG
25gluten449.5APOH, CD79A
26con a449.5CD79A, IFNA2
27agar449.5CD79A, IFNA2, CD40LG
28epinephrine44 24 1111.4CD40LG, IFNA2, CD79A
29ascorbic acid44 2410.4CD40LG, CD79A, IFNA2
30indomethacin44 28 61 1112.4IFNA2, CD79A, CD40LG
31hydroxychloroquine44 1110.3CD40LG, IFNA2, APOH
32cardiolipin44 1110.2APOH, CD40LG, CD79A
33ivig449.2APOH, CD79A, CD40LG
34vitamin b12449.2CD79A, CD40LG, APOH
35folate449.2APOH, CD79A, CD40LG
36phosphatidylserine44 28 1111.1APOH, CD40LG, CD79A
37aspirin44 50 28 2412.1CD40LG, CD79A, APOH
38betacarotene449.1APOH, CD79A, IFNA2
39galactose449.1APOH, IFNA2, CD79A
40azathioprine44 2 50 1112.1CD79A, IFNA2, APOH
41prednisolone44 28 1111.1IFNA2, APOH, CD79A
42cyclophosphamide44 50 1111.1APOH, BCR, IFNA2
43sialic acid449.0CD79A, BCR, APOH
44fibrinogen448.9CD40LG, CD79A, APOH
45histamine44 28 2410.9CD40LG, CD79A, IFNA2
46vegf448.7CD40LG, IFNA2, CD79A, APOH
47heparin44 28 24 1111.7CD40LG, APOH, CD79A, BCR
48cysteine448.5CD40LG, BCR, IFNA2, CD79A
49estrogen448.4CD40LG, IFNA2, CD79A, APOH
50rituximab44 50 1110.3APOH, IFNA2, BCR, CD79A, CD40LG

GO Terms for genes affiliated with Cryoglobulinemia

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Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD40LG, CD79A, CD5
2extracellular spaceGO:0056158.5CD40LG, IFNA2, TSLP, APOH

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.6CD40LG, CD79A
2B cell proliferationGO:0421009.3CD40LG, CD79A

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3CD40LG, IFNA2, TSLP

Products for genes affiliated with Cryoglobulinemia

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Sources for Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet