Aliases & Classifications for Cryoglobulinemia

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Cryoglobulinemia, Aliases & Descriptions:

Name: Cryoglobulinemia 9 41 11 43 60
 
Cryoimmunoglobulinaemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:2917
MeSH33 D003449
SNOMED-CT55 30911005
NCIt38 C26736

Summaries for Cryoglobulinemia

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NIH Rare Diseases:41 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis c and glomerulonephritis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Antigen Activates B Cell Receptor Leading to Generation of Second Messengers. The drugs interferon alfa-2a and interferon alfa-2b and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:9 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:63 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.8CD40LG, IFNA2
2glomerulonephritis31.1CD40LG, CD79A, TSLP
3purpura31.1CD79A
4membranoproliferative glomerulonephritis30.9TSLP, IFNA2, CD79A
5macroglobulinemia30.8CD79A, CD5
6q fever30.7CD79A
7polyarteritis nodosa30.5IFNA2
8hepatitis b30.5CD79A, IFNA2, IGHM
9b-cell lymphomas30.4CD5, BCR, IGHM
10vasculitis30.4IGHM, APOH, IFNA2, CD79A, CD40LG
11viral hepatitis30.4IFNA2
12waldenstrom macroglobulinemia30.3IGHM, CD40LG
13malt lymphoma30.3IGHM, CD5
14retinal vasculitis30.2APOH
15polyneuropathy30.2CD40LG, CD79A, IFNA2
16lupus erythematosus30.1APOH, CD79A, CD40LG
17chronic lymphocytic leukemia30.0IGHM, BCR, CD5, CD40LG
18myeloma30.0IGHM, IFNA2, BCR, CD79A, CD40LG
19cryoglobulinemia, familial mixed30.0IGHM, TSLP, IFNA2, BCR, CD5, CD40LG
20nephritis29.9CD40LG, CD79A, APOH
21leukemia29.9IFNA2, BCR, CD5, CD79A, CD40LG
22antiphospholipid syndrome29.7CD40LG, CD79A, APOH
23thrombocytopenia29.6CD40LG, CD79A, IFNA2, APOH
24rheumatoid arthritis29.5IGHM, APOH, CD5, CD79A, CD40LG
25systemic lupus erythematosus29.4CD40LG, CD79A, BCR, APOH, IGHM
26hepatitis11.1
27hepatitis c virus11.0
28type ii mixed cryoglobulinemia10.7
29neuropathy10.5
30dysentery10.4CD79A
31chickenpox10.4CD79A
32agammaglobulinemia 310.4CD79A
33mumps10.4CD79A
34cryptosporidiosis10.4CD79A
35peripheral neuropathy10.4
36multiple myeloma10.4
37thyroiditis10.3
38liver disease10.3
39arthritis10.3
40degos disease10.3APOH
41congenital toxoplasmosis10.3CD40LG, CD79A
42immunoglobulin g deficiency10.3CD40LG, CD79A
43selective iga deficiency disease10.3CD79A, CD40LG
44immunodeficiency, centromere instability and facial anomalies syndrome10.3CD40LG, CD79A
45immunoglobulin alpha deficiency10.3CD79A, CD40LG
46immunodeficiency, x-linked, with hyper-igm10.3CD40LG, CD79A
47autoimmune thyroiditis10.3
48rubella10.3CD79A, CD40LG
49pfeiffer syndrome10.2CD40LG, CD79A
50autoimmune hemolytic anemia10.2CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

31
Skin, B cells, Liver, Kidney, Thyroid, Bone, Brain, Bone marrow, T cells, Endothelial, Neutrophil, Lymph node, Lung, Testes, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Monocytes, Nk cells

Animal Models for Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Cryoglobulinemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5CD40LG, CD79A, BCR, IGHM
2MP:00053977.7CD40LG, CD79A, CD5, BCR, TSLP, IGHM
3MP:00053877.6IGHM, TSLP, BCR, CD5, CD79A, CD40LG
4MP:00053767.0IGHM, APOH, TSLP, BCR, CD79A, CD40LG

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 776)
idTitleAuthorsYear
1
Pulmonary hemorrhage in cryoglobulinemia. (25493699)
2015
2
Influence of HCV and HIV on Development of Cryoglobulinemia. (25723551)
2015
3
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)
2015
4
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
5
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
6
The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)
2011
7
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
8
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
9
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
10
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
11
Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)
2010
12
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
13
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
14
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
15
Cryoglobulinemia and renal disease. (18408474)
2008
16
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
17
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
18
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)
2008
19
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
20
Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)
2007
21
Cryoglobulinemia. (17289231)
2007
22
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
23
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
24
Images in clinical medicine. Mixed cryoglobulinemia. (15972869)
2005
25
Successful treatment of necrotizing vasculitic lesions after infusion of iloprost in a patient with cryoglobulinemia and chronic HCV infection. (16396716)
2005
26
Autoamputation in a patient with cryoglobulinemia. (15468383)
2004
27
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
28
HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)
2003
29
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
30
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
31
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
32
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
33
Cryoglobulinemia. (10626153)
1999
34
Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)
1999
35
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
36
Exacerbation of peripheral neuropathy during alpha-interferon therapy in a patient with mixed cryoglobulinemia and hepatitis B virus infection. (8877939)
1996
37
Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)
1995
38
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
39
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
40
The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)
1994
41
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
42
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
43
Cryoglobulinemia type II]. (2074925)
1990
44
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
45
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
46
Synovial fluid in mixed cryoglobulinemia. (737009)
1978
47
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978
48
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
49
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, CD79A
2
Show member pathways
9.3CD79A, IGHM
38.9CD79A, CD5, IGHM

Compounds for genes affiliated with Cryoglobulinemia

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Compounds related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4310.0CD79A, CD40LG
2sandoglobulin4310.0CD40LG, CD79A
3vancomycin43 1211.0CD79A, CD40LG
4pneumococcal4310.0CD40LG, CD79A
5tuberculin4310.0CD79A, CD40LG
6chlorambucil43 1211.0CD40LG, IFNA2
7praziquantel43 1211.0CD79A, CD40LG
8hemocyanin4310.0CD40LG, CD79A
9fluorochrome439.9CD40LG, BCR
10gliadin439.9CD40LG, CD79A
11mizoribine439.9CD79A, IFNA2
12pmma439.9CD40LG, CD79A
13silicone439.9CD40LG, CD79A
14busulfan43 49 1211.8BCR, IFNA2
15mannan439.8CD40LG, CD79A
16dapsone43 2 49 1212.7CD79A, IFNA2
17allergens439.7TSLP, CD79A, CD40LG
18isotretinoin43 1210.6CD79A, IFNA2
19okt3439.6CD40LG, CD79A
20gamma globulin439.6IFNA2, CD79A, CD40LG
21neopterin439.6CD40LG, CD79A, IFNA2
22polyethylene glycol439.6CD40LG, CD79A, IFNA2
23thyroxine43 2410.5CD40LG, CD79A, IFNA2
24blys439.5BCR, CD79A, CD40LG
25gluten439.5CD79A, APOH
26con a439.5CD79A, IFNA2
27agar439.5IFNA2, CD79A, CD40LG
28epinephrine43 24 1211.4IFNA2, CD79A, CD40LG
29ascorbic acid43 2410.4CD40LG, CD79A, IFNA2
30indomethacin43 28 59 1212.4IFNA2, CD79A, CD40LG
31hydroxychloroquine43 1210.3APOH, IFNA2, CD40LG
32cardiolipin43 1210.2CD40LG, CD79A, APOH
33ivig439.2CD40LG, CD79A, APOH
34vitamin b12439.2APOH, CD79A, CD40LG
35folate439.2CD40LG, CD79A, APOH
36phosphatidylserine43 28 1211.1CD40LG, CD79A, APOH
37aspirin43 49 28 2412.1APOH, CD79A, CD40LG
38betacarotene439.1CD79A, IFNA2, APOH
39galactose439.1APOH, IFNA2, CD79A
40azathioprine43 2 49 1212.1CD79A, IFNA2, APOH
41prednisolone43 28 1211.1APOH, IFNA2, CD79A
42cyclophosphamide43 49 1211.1APOH, IFNA2, BCR
43sialic acid439.0CD79A, BCR, APOH
44fibrinogen438.9CD40LG, CD79A, APOH
45histamine43 28 2410.9CD40LG, CD79A, IFNA2
46vegf438.7CD40LG, CD79A, IFNA2, APOH
47heparin43 28 24 1211.7CD40LG, CD79A, BCR, APOH
48cysteine438.5IFNA2, BCR, CD79A, CD40LG
49estrogen438.4APOH, IFNA2, CD79A, CD40LG
50rituximab43 49 1210.3CD40LG, CD79A, BCR, IFNA2, APOH

GO Terms for genes affiliated with Cryoglobulinemia

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Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CD40LG, CD79A, CD5
2extracellular spaceGO:00056158.5CD40LG, IFNA2, TSLP, APOH

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:00301839.6CD40LG, CD79A
2B cell proliferationGO:00421009.3CD40LG, CD79A

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.3CD40LG, IFNA2, TSLP

Products for genes affiliated with Cryoglobulinemia

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Sources for Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet