MCID: CRY004
MIFTS: 45

Cryoglobulinemia malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

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Aliases & Descriptions for Cryoglobulinemia:

Name: Cryoglobulinemia 10 45 47 12 36 65
 
Cryoimmunoglobulinaemia 10

Classifications:



External Ids:

Disease Ontology10 DOID:2917
ICD1027 D89.1
SNOMED-CT59 30911005
MeSH36 D003449
NCIt42 C26736
UMLS65 C0010403

Summaries for Cryoglobulinemia

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NIH Rare Diseases:45 Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to typhus and pulmonary edema. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Inflammatory Response Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:10 A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:68 Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 643)
idRelated DiseaseScoreTop Affiliating Genes
1typhus30.3CD40LG, CD79A
2pulmonary edema30.3CD40LG, CD79A
3narcissistic personality disorder30.1CD40LG, CD79A
4complex regional pain syndrome29.9CD27, IFNA2
5malaria29.9CD40LG, CD81, CXCL10, CXCL11
6capillary hemangioma29.9CD40LG, CD79A, TSLP
7transient global amnesia29.7CR2, FN1
8systemic lupus erythematosus29.3CD40LG, CD79A, CR2, CXCL10, TNFSF13B
9familial mixed cryoglobulinemia12.5
10simple cryoglobulinemia12.3
11mixed cryoglobulinemia type iii12.3
12type ii mixed cryoglobulinemia12.3
13cryoglobulinemic vasculitis11.8
14rare endometriosis10.5CXCL10, CXCL11
15rickettsia parkeri spotted fever10.5CD40LG, CXCL10
16congenital hypogammaglobulinemia10.4CD40LG, CD79A
17calabro syndrome10.4CD40LG, CD79A
18gamma heavy chain disease10.4CD40LG, CD79A
19exanthema subitum10.4CD40LG, CD79A
20osteomalacia10.4CD40LG, CD79A
21epidermolysis bullosa simplex10.4CD40LG, CD79A
22proliferative glomerulonephritis10.4CD40LG, CD79A
23acute salpingitis10.4CD40LG, CD79A
24beriberi10.4CD40LG, CD79A
25cystitis10.4CD40LG, CD79A
26purpura10.4CD40LG, CD79A
27choroid plexus meningioma10.4CD40LG, CD79A
28immunotactoid glomerulopathy10.4CD40LG, CD79A
29subacute delirium10.4CD40LG, CD79A
30chronic hiccups10.4CD79A, TNFSF13B
31alpha chain disease10.4CD40LG, CD79A
32dysgammaglobulinemia10.4CD40LG, CD79A
33generalized atherosclerosis10.4CD40LG, CD79A
34central sleep apnea10.4CD40LG, CD79A
35sialadenitis10.4CD40LG, CD79A
36ureteral lymphoma10.4CD40LG, CD79A
37mixed lacrimal gland cancer10.4CD40LG, CD79A
38somatoform disorder10.4CD40LG, CD79A
39duodenal benign neoplasm10.4CD79A, CXCL10
40aids phobia10.4CD40LG, CD79A
41ocular hypotension10.4CD40LG, CD79A
42tenosynovitis10.4CD40LG, CD79A
43hyperostosis10.4CD40LG, IFNA2
44brucella melitensis brucellosis10.4CD40LG, CD79A
45fallopian tube carcinoma10.4CD40LG, CD79A
46maxillary sinusitis10.4CD40LG, CD79A
47plasma protein metabolism disease10.4CD40LG, CD79A
48peripheral nervous system disease10.4CD40LG, CD79A
49impaired renal function disease10.4CD40LG, CD79A
50parasitic conjunctivitis10.4CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 4, Phase 2, Phase 31582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 4, Phase 2, Phase 38496
3Immunologic FactorsPhase 4, Phase 2, Phase 318483
4
AldesleukinapprovedPhase 1, Phase 238785898-30-2
Synonyms:
IL-2
Interleukin-2 precursor
 
Proleukin
T-cell growth factor
TCGF
5
PrednisoneapprovedPhase 2126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
6ImmunoglobulinsPhase 24477
7Antibodies, MonoclonalPhase 22413
8AntibodiesPhase 24477
9
LactitolPhase 1, Phase 2320585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
10AnalgesicsPhase 1, Phase 29358
11Analgesics, Non-NarcoticPhase 1, Phase 25184
12Interleukin-2Phase 1, Phase 2487
13
s 1 (combination)Phase 1, Phase 2325
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
14Peripheral Nervous System AgentsPhase 1, Phase 218510
15glucocorticoidsPhase 23896
16Anti-Inflammatory AgentsPhase 28478
17Antineoplastic Agents, HormonalPhase 24256
18Hormone AntagonistsPhase 210002
19Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
20HormonesPhase 211748
21Liver Extracts3572

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Study of the Influence of Plasma Exchange on the Pharmacokinetics of RituximabCompletedNCT00820469Phase 4
2Tolerance and Efficacy of Rituximab in Sjogren's DiseaseCompletedNCT00740948Phase 2, Phase 3
3Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis PatientsCompletedNCT00574652Phase 1, Phase 2
4Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2
5Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia VasculitisRecruitingNCT02556866Phase 2
6Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia AreataRecruitingNCT01840046Phase 1, Phase 2
7The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune DisordersCompletedNCT00960713
8Hepatitis C Virus and the Humoral Immune SystemCompletedNCT00219999
9Characterization of Clonal B Cell Populations in HCV InfectionCompletedNCT00435201
10Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
11Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingRecruitingNCT01932021
12Vasculitis Pregnancy RegistryRecruitingNCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

33
Skin, Breast, Bone, B cells, Lung, Prostate, Endothelial

Animal Models for Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Cryoglobulinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.3CD27, CD40LG, CD5, CD79A, CD81, CR2
2MP:00053876.0CD27, CD40LG, CD5, CD79A, CD81, CR2

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 805)
idTitleAuthorsYear
1
Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. (26981933)
2016
2
Gastric inverted hyperplastic polyp: A rare cause of iron deficiency anemia. (27099452)
2016
3
SEC14L2 enables pan-genotype HCV replication in cell culture. (26266980)
2015
4
Severe immune dysregulation with neurological impairment and minor bone changes in a child with spondyloenchondrodysplasia due to two novel mutations in the ACP5 gene. (26346816)
2015
5
PRIMARY HYPERPARATHYROIDISM, WITH A FOCUS ON MANAGMENT OF THE NORMOCALCEMIC FORM. TO TREAT OR NOT TO TREAT? (26523628)
2015
6
Case of non-Herlitz junctional epidermolysis bullosa with COL17A1 mutation. (25573436)
2015
7
The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation. (26715087)
2015
8
Liver-inherent immune system: its role in blood-stage malaria. (25408684)
2014
9
Pulmonary adenocarcinoma with osseous metaplasia: a rare occurrence possibly associated with early stage? (24250229)
2013
10
Management of facial erythema of rosacea: what is the role of topical I+-adrenergic receptor agonist therapy? (24229637)
2013
11
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. (23801362)
2013
12
Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (23116464)
2012
13
Temporal artery flow response during the last minute of a head up tilt test, in relation with orthostatic intolerance after a 60 day head-down bedrest. (22073117)
2011
14
An immunocytochemical assay to detect human CFTR expression following gene transfer. (19615439)
2009
15
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
16
TRPC3 activation by erythropoietin is modulated by TRPC6. (19074769)
2009
17
Exenatide efficacy and safety: a systematic review. (19719703)
2009
18
Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. (18404646)
2008
19
Bilateral osteochondrosis of the superior pole of the patellae in association with bilateral osteochondritis dissecans of the lateral femoral condyle. (18325370)
2008
20
Shiga toxin produced by enterohemorrhagic Escherichia coli inhibits PI3K/NF-kappaB signaling pathway in globotriaosylceramide-3-negative human intestinal epithelial cells. (17548655)
2007
21
The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure. (16451871)
2006
22
Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck). (16631599)
2006
23
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
24
Neoangiogenesis and coronary atherosclerosis: diagnostic value of a novel biochemical marker placenta growth factor in patients with ischemic heart disease]. (17159877)
2006
25
Preimplantation genetic diagnosis for Pelizaeus-Merzbacher disease with testing for age-related aneuploidies. (16454941)
2006
26
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. (15701693)
2005
27
Large supratentorial ectopic ependymoma with massive calcification and cyst formation--case report. (15508351)
2004
28
Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries. (15167831)
2004
29
The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk. (12516098)
2003
30
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. (12594313)
2003
31
Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease. (14642682)
2003
32
Thyroid peroxidase antibodies in dried blood specimens of newborns. (12193306)
2002
33
Stimulation and inhibition of uveal melanoma invasion by HGF, GRO, IL-1alpha and TGF-beta. (12356817)
2002
34
Fetal alcohol syndrome: What you should know about drinking during pregnancy. (20046290)
2002
35
Phase II clinical study on the effects of recombinant human interleukin-3 on thrombocytopenia after chemotherapy for advanced ovarian cancer. SDZ ILE 964 [IL-3] Study Group. (10570752)
1999
36
Genetic, morphometric and immunohistochemical markers of latent coeliac disease. (10563541)
1999
37
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas. (9285563)
1997
38
Pathology of skeletal muscle and impaired respiratory chain function in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency with the G1528C mutation. (8938697)
1996
39
Diagnosis and management of viral retinitis in the acute retinal necrosis syndrome. (10155697)
1995
40
Lymphangiomatosis of the limbs. Clinicopathologic analysis of a series with a good prognosis. (7832272)
1995
41
Monitoring anticoagulation following intracoronary procedures: which method? (7960247)
1994
42
The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. (8128316)
1993
43
Cutaneous mastocytosis in a dog. (1514225)
1992
44
Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. (1789255)
1991
45
Lymphotoxin induces secretion of granule proteins from adherent neutrophils: possible role of intracellular free calcium. (2161892)
1990
46
Current concepts on bronchoalveolar lavage cells in extrinsic allergic alveolitis. (3068746)
1988
47
Chronic recurrent multifocal osteomyelitis. A case report. (6480641)
1984
48
Lysosomal enzymes and vitamin E deficiency. I. Muscular dystrophy, encephalomalacia and exudative diathesis in the chick. (6024270)
1967
49
Balanitis xerotica obliterans; a case report. (13152866)
1954
50

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7CD40LG, FN1
29.4CD5, CD79A, IFNA2
39.2CD40LG, CR2, TNFSF13B
4
Show member pathways
8.9CD40LG, CR2, TNFSF13B
5
Show member pathways
8.8CXCL10, CXCL11, FN1
6
Show member pathways
8.7CXCL10, CXCL11, FN1
78.6CD27, CD40LG, CD5, CR2
8
Show member pathways
7.5CD27, CD40LG, CXCL10, CXCL11, IFNA2, TNFSF13B
9
Show member pathways
7.5CD27, CD40LG, CD79A, CD81, CXCL10, FN1

GO Terms for genes affiliated with Cryoglobulinemia

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Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1T cell chemotaxisGO:00108189.6CXCL10, CXCL11
2positive regulation of cAMP-mediated signalingGO:00439509.5CXCL10, CXCL11
3inflammatory responseGO:00069549.5CD27, CXCL10, IFNA2
4cell-cell signalingGO:00072679.2CXCL10, CXCL11, IFNA2
5cell surface receptor signaling pathwayGO:00071669.2CD27, CD81, CXCL10, IFNA2
6response to lipopolysaccharideGO:00324968.8CD27, CXCL10, CXCL11
7immune responseGO:00069557.8CD27, CR2, CXCL10, CXCL11, TNFSF13B

Sources for Cryoglobulinemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet