Cryoglobulinemia malady

NIH Rare Diseases: Cryoglobulinemia is a condition that can affect blood vessels throughout the body. This condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. These abnormal proteins become solid in cold temperatures and block blood flow. Symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, Raynaud's phenomenon, skin ulcers, and skin death.³⁰

MalaCards: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis and hepatitis c. An important gene associated with Cryoglobulinemia is TSLP (thymic stromal lymphopoietin), and among its related pathways are Graft-versus-host disease and RAR-Gamma-RXR-Alpha Degradation. The drugs interferon beta-1b,recombinant and peginterferon alfa-2a and the compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include brain, small intestine and kidney, and related mouse phenotypes are respiratory system and renal/urinary system.

Disease Ontology: A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.⁶

Wikipedia: Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -...⁴⁴ more...

Aliases & Descriptions:

cryoglobulinemia 6 30 8 32 43 cryoimmunoglobulinaemia 6

Diseases related to cryoglobulinemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 812)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	35.3	GPT, IFNA1, SLC17A5
2	hepatitis c	29.4	MX1, CD81, CD40LG, IL10, IL4, FAS
3	hodgkin's lymphoma	28.8	BIRC3, BCL2, BCR, IGHM, HSP90AA1, HSPA4
4	b-cell lymphomas	28.1	BIRC3, BCL2, BCR, CD81, CD5, FAS
5	calciphylaxis	27.9	CD79A, CD40LG, FN1, EPO
6	antiphospholipid syndrome	27.9	APOH, F2
7	non-hodgkin lymphoma	27.8	BIRC3, BCL2, BCR, CD27, CD5, FAS
8	marginal zone b-cell lymphoma	27.8	BIRC3, CD79A, CD40LG, FAS, MALT1
9	autoimmune thyroiditis	27.6	IL4, FASLG, FAS, IFNG, ICAM1
10	venous thrombosis	27.2	VWF, APOH, F2, PLAT
11	pure red-cell aplasia	27.0	CD79A, CD40LG, IFNA1, F2, HLA-DQB1, HLA-DRB1
12	malt lymphoma	26.8	BIRC3, BCL2, CD79A, CD5, MALT1, IGHM
13	liver cirrhosis	26.2	GPT, IFNA1, IFNA2, F2, HSPA4, HLA-DRB1
14	peripheral neuropathy	25.6	SELE, CD40LG, IL10, IGHM, IFNA1, IFNG
15	churg-strauss syndrome	25.5	IL10, IL4, FAS, IFNA1, IFNG, HLA-DRB1
16	rheumatoid arthritis	25.2	IL10, IL1B, HLA-DRB1, TNF
17	b-cell non-hodgkin lymphoma	24.8	BCL2, IL10, IL4, FASLG, FAS, MALT1
18	hepatitis b	24.4	MX1, IL10, GPT, IFNA1, IFNA2, IFNG
19	polyneuropathy	23.7	BMP6, CD79A, CD40LG, IL10, IL1B, GPT
20	immunodeficiency	22.8	BMP6, BCR, CD79A, CD81, CD40LG, IL10
21	neuropathy	21.7	VWF, SELE, MT1H, CD79A, CD40LG, MMP7
22	vasculitis	21.6	VWF, SELE, VCAM1, BMP6, MT1H, CD79A
23	thrombosis	19.9	VWF, SELE, VCAM1, CD79A, CD40LG, FN1
24	systemic lupus erythematosus	19.3	VWF, SELE, VCAM1, BCR, MX1, CD79A
25	glomerulonephritis	18.5	VWF, VCAM1, BMP6, BCL2, CD79A, CD40LG
26	peritonitis	17.3	VWF, SELE, VCAM1, BMP6, BCL2, CD79A
27	thyroiditis	17.2	VWF, SELE, VCAM1, BMP6, BCL2, CD79A
28	lymphocytic leukemia	16.8	VCAM1, BMP6, BIRC3, BCL2, BCR, MX1
29	arthritis	16.0	VWF, SELE, VCAM1, BMP6, BCL2, MX1
30	lupus erythematosus	15.0	VWF, SELE, VCAM1, BMP6, BCL2, BCR
31	leukemia	14.0	VWF, SELE, VCAM1, BMP6, BIRC3, BCL2
32	membranoproliferative glomerulonephritis type 2	13.8	CD79A, IFNA2, TSLP
33	cryofibrinogenemia	13.8	CD79A, CD40LG, FN1
34	autoimmune thrombocytopenic purpura	13.8	CD79A, CD40LG, IFNA1, IFNA2
35	cd40 ligand deficiency	13.8	CD79A, CD40LG, C6orf25
36	secondary syphilis	13.8	CD79A, CD40LG, FN1
37	congenital toxoplasmosis	13.7	CD79A, CD40LG
38	immunoglobulin alpha deficiency	13.7	CD79A, CD40LG, HLA-DQB1
39	granulomatous hepatitis	13.7	IFNA1, IFNA2
40	collagenous colitis	13.7	CD79A, CD40LG, APOH
41	hepatitis d	13.7	GPT, IFNA1, IFNA2
42	21-hydroxylase deficiency	13.7	GPT, IFNA1, IFNA2, SLC17A5
43	polyarteritis nodosa	13.7	CD40LG, APOH, GPT, IFNA1, IFNA2
44	splenic marginal zone lymphoma	13.6	BIRC3, BCR, CD5, MALT1
45	iritis	13.6	CD79A, CD40LG, EPO
46	diffuse infiltrative lymphocytosis syndrome	13.6	BCR, CD5, FASLG
47	scrub typhus	13.6	CD40LG, GPT, SLC17A5
48	sneddon syndrome	13.6	CD79A, APOH, F2
49	berger disease	13.5	BMP6, CD79A, CD40LG
50	neonatal intrahepatic cholestasis caused by citrin deficiency	13.5	GPT, F2, SLC17A5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, peginterferon alfa-2a, peginterferon alfa-2b

MalaCards organs/tissues related to cryoglobulinemia:

²²

MGI Mouse Phenotypes related to cryoglobulinemia:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	CD81, IGHM
2	renal/urinary system phenotype	MP:0005367	9.9	BCL2, BCR, IGHM
3	skeleton phenotype	MP:0005390	9.8	PLAT, FAS, FN1, CD81, BMP6
4	liver/biliary system phenotype	MP:0005370	9.2	IFNG, TLR2, EPO
5	endocrine/exocrine gland phenotype	MP:0005379	9.2	TLR2, IFNG, FASLG, CD40LG
6	hematopoietic system phenotype	MP:0005397	9.1	EPO, TSLP, TNFSF13B, HLA-DQB1, IGHM, MALT1
7	nervous system phenotype	MP:0003631	9.0	SLC17A5, CXCL10, TLR2, HLA-DQB1, HSPA4, F2
8	growth/size phenotype	MP:0005378	8.8	FAS, ENO1, IGHM, PLAT, TSLP, MMP7
9	integument phenotype	MP:0010771	8.0	TLR2, F2, IFNG, IGHM, FAS, FASLG
10	digestive/alimentary phenotype	MP:0005381	7.9	TLR2, TSLP, PLAT, F2, IFNG, IGHM
11	reproductive system phenotype	MP:0005389	7.6	TNF, IFNG, CCL2, FASLG, IL4, IL10
12	immune system phenotype	MP:0005387	7.4	VWF, TNF, HLA-DQB1, HSP90AA1, F2, IFNG
13	muscle phenotype	MP:0005369	7.0	NPPB, TLR2, PLAT, TNF, HLA-DQB1, ICAM1
14	mortality/aging	MP:0010768	6.9	IFNG, F2, HSPA4, HLA-DQB1, PLAT, TSLP
15	normal phenotype	MP:0002873	6.7	EPO, TLR2, HLA-DQB1, F2, IFNG, IGHM
16	homeostasis/metabolism phenotype	MP:0005376	6.5	FAS, CCL2, IGHM, ICAM1, F2, HLA-DQB1
17	tumorigenesis	MP:0002006	6.1	IGHM, IFNG, ICAM1, TNF, TLR2, CCL2
18	vision/eye phenotype	MP:0005391	6.1	SLC17A5, PLAT, TNF, ICAM1, IFNG, CCL2
19	cardiovascular system phenotype	MP:0005385	4.3	HLA-DQB1, F2, ICAM1, IFNG, TNF, PLAT
20	cellular phenotype	MP:0005384	3.2	TNFSF13B, TNF, HLA-DQB1, HSPA4, HSP90AA1, F2

Articles related to cryoglobulinemia:

(show top 50)    (show all 78)

id	Title	Authors	Year	Affiliating Genes
1	Serum concentrations of interleukin 1beta, CXCL10, an d interferon-gamma in mixed cryoglobulinemia associated with hepatitis C infect ion. (19918044)	Antonelli A.... Fallahi P.	2010	IL1B, IFNG, CXCL10
2	HLA DR-DQ combination associated with the increased r isk of developing human HCV positive non-Hodgkin's lymphoma is related to the t ype II mixed cryoglobulinemia. (20002609)	De Re V.... Toffoli G.	2010	HLA-DQB1, HLA-DRB1
3	Interleukin-1I^, C-x-C motif ligand 10, and interferon -gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroi ditis. (20929277)	Antonelli A.... Fallahi P.	2010	IL1B, CXCL10
4	Characterization of antibodies directed against the i mmunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus -related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)	De Re V.... Toffoli G.	2009	BCR
5	High circulating N-terminal pro-brain natriuretic pep tide and tumor necrosis factor-alpha in mixed cryoglobulinemia. (19860001)	Antonelli A.... Fallahi P.	2009	TNF, NPPB
6	Persisting mixed cryoglobulinemia in Chikungunya infe ction. (19190731)	Oliver M.... Simon F.	2009	C1QBP
7	Can BAFF promoter polymorphism be a predisposing condition for HCV-related mixed cryoglobulinemia? (18988879)	Giannini C.... Zignego A.L.	2008	TNFSF13B
8	Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditis. (18702954)	Antonelli A.... Ferrannini E.	2008	CCL2, CXCL10
9	Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. (18550853)	Sansonno D.... Dammacco F.	2008	CXCL13
10	High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)	Antonelli A.... Ferrannini E.	2008	TNF, IFNG, CXCL10
11	Hepatitis C-associated leukocytoclastic vasculitis wi th anticardiolipin antibodies causing penile necrosis and deep venous thrombosi s in the absence of cryoglobulinemia. (18438797)	Daniels A.H.... Harrison R.A.	2008	APOH
12	High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis. (18282714)	Antonelli A.... Ferrannini E.	2008	CXCL10
13	Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. (17322382)	Kowalewska J.... Alpers C.E.	2007	TSLP
14	Improvement in liver cirrhosis after treatment of HCV-related mixed cryoglobulinemia with rituximab. (17936214)	Petrarca A.... Zignego A.L.	2007	F2
15	Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative stress-derived molecules in hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. (17393409)	Saadoun D.... Cacoub P.	2007	MMP7, HSP90AA1, HSPA4
16	Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma. (16899594)	Feldmann G.... Spengler U.	2006	TLR2
17	Polyneuropathy with demyelinating features in mixed cryoglobulinemia with hepatitis C virus infection. (16930357)	Boukhris S.... Vallat J.M.	2006	GPT
18	Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. (16142759)	Saadoun D.... Cacoub P.	2005	TNF
19	Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in the pathogenesis of severe forms of vasculitis due to hepatitis C-associated mixed cryoglobulinemia. (15710215)	Kaplanski G.... Cacoub P.	2005	ICAM1, SELE, VCAM1
20	Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis. (15582138)	Saadoun D.... Cacoub P.	2004	TNF, IL4, IL10
21	Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) arising in the small intestine with monoclonal cryoglobulinemia. (15363040)	Saito T.... Mikata I.	2004	MALT1, BIRC3
22	Association of HCV-related mixed cryoglobulinemia with specific mutational pattern of the HCV E2 protein and CD81 expression on peripheral B lymphocytes. (15294858)	Hofmann W.P.... Sarrazin C.	2004	CD81
23	Pure red-cell aplasia in a peritoneal dialysis patient with HCV-related cryoglobulinemia in the absence of neutralizing antierythropoietin antibodies. (15593045)	Aterini S.... Amato M.	2004	EPO
24	Interferon plus ribavirin in patients with hepatitis C virus positive mixed cryoglobulinemia resistant to interferon. (12913934)	Mazzaro C.... Pozzato G.	2003	IFNA1
25	Serum interferon (IFN)-neutralizing antibodies and bioactivities of IFNs in patients with severe type II essential mixed cryoglobulinemia. (12522042)	Scagnolari C.... Antonelli G.	2003	MX1, IFNA1
26	Factors predisposing to the occurrence of cryoglobulinemia in two cohorts of Egyptian and Japanese patients with chronic hepatitis C infection: ethnic and genotypic influence. (12794722)	Gad A.... Kiyosawa K.	2003	GPT
27	Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia. (11877309)	Casato M.... Kay J.	2002	BCL2
28	Influence of HLA-DR phenotype on the risk of hepatitis C virus-associated mixed cryoglobulinemia. (11592376)	Cacoub P.... Caillat-Zucman S.	2001	HLA-DRB1
29	Cryoglobulinemia associated with Purtscher-like retinopathy. (11384584)	Myers J.P.... Mann E.S.	2001	CD40LG
30	Characterization of cryoglobulin, M protein, low molecular weight IgM in a patient with chronic hepatitis C and type II mixed cryoglobulinemia (11769562)	Nishiyama Y.... Ichiyama S.	2001	CD40LG
31	Treatment of refractory, symptomatic, hepatitis C virus related mixed cryoglobulinemia with ribavirin and interferon-alpha. (10990230)	Zuckerman E.... Yeshurun D.	2000	IFNA1
32	Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia. (11071657)	De Re V.... Boiocchi M.	2000	C6orf25
33	Hepatitis C virus infection with and without cryoglobulinemia as a case of Churg-Strauss syndrome. (10743831)	MerciAc P.... Pellegrin J.L.	2000	IFNA1
34	Cryoglobulinemia. (10626153)	Dispenzieri A.... Gorevic P.D.	1999	IFNA1
35	Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies (9161561)	Jacq F.... Fiessinger J.N.	1997	APOH
36	Interferon-alpha treatment of hepatitis C virus-associated mixed cryoglobulinemia. (9252075)	Polzien F.... Hartmann H.	1997	IFNA2
37	Nonrheumatoid IgM in human hepatitis C virus-associated type II cryoglobulinemia recognize mimotopes of the CD4-like LAG-3 protein. (8871676)	Mecchia M.... Nicosia A.	1996	LAG3
38	Cryoglobulinemia in hepatitis C virus chronic active hepatitis: effects of interferon-alpha therapy. (8877728)	Casaril M.... Corrocher R.	1996	IFNA1
39	Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia. Evidence for somatic mutations and intraclonal diversity of the expressed VH region gene. (7527818)	Crouzier R.... Pasquali J.L.	1995	CD40LG
40	Effects of two different alpha-interferon regimens on clinical and virological findings in mixed cryoglobulinemia. (8730503)	Mazzaro C.... Pozzato G.	1995	IFNA1
41	Long-term results regarding the use of recombinant interferon alpha-2b in the treatment of II type mixed essential cryoglobulinemia. (8832526)	Lauta V.M.... De Sangro M.A.	1995	IFNA2
42	Lymphoproliferation in type II mixed cryoglobulinemia. (8730495)	Monteverde A.... Pileri S.	1995	CD5
43	Resistance to recombinant alpha interferon therapy in idiopathic mixed cryoglobulinemia: reinduction of remission by natural alpha interferon both in antibody-positive and -negative patients. (7863814)	Casato M.... Bonomo L.	1994	IFNA2
44	Interferon-alpha in mixed cryoglobulinemia patients: a randomized, crossover-controlled trial. (8382969)	Ferri C.... Moretti A.	1993	IFNA1
45	Pseudoleukocytosis in cryoglobulinemia type I (8444103)	WAPltjen H.H.... Bremer K.	1993	IFNA2
46	Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma. (1300443)	Rollino C.... Cordonnier D.	1992	CD79A
47	The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)	Pasquali J.L.... Levallois H.	1991	CD5
48	Clinical significance of endothelial damage markers in essential mixed cryoglobulinemia. (1950376)	Toschi V.... Gibelli A.	1991	VWF, PLAT, FN1
49	Low number of complement C3b/C4b receptors (CR1) on erythrocytes from patients with essential mixed cryoglobulinemia, systemic lupus erythematosus and rheumatoid arthritis: relationship with disease activity, anticardiolipin antibodies, complement activation and therapy. (1833542)	Corvetta A.... Danieli G.	1991	APOH, CR1
50	Cryoglobulinemia type II (2074925)	Madi N.... Schifferli J.A.	1990	CD40LG

Genes related to cryoglobulinemia according to GeneCards:

(show top 50)    (show all 53)

id	Symbol	Description	Score	GeneCards Section Context
1	TSLP	thymic stromal lymphopoietin	11.0	Publications
2	CD40LG	CD40 ligand	11.0	Publications
3	IFNA1	interferon, alpha 1	11.0	Publications
4	IFNA2	interferon, alpha 2	11.0	Publications
5	IGHM	immunoglobulin heavy constant mu	11.0	Publications
6	CD5	CD5 molecule	11.0	Publications
7	ENO1	enolase 1, (alpha)	11.0	Publications
8	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
9	BCR	breakpoint cluster region	11.0	Publications
10	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
11	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
12	MT1H	metallothionein 1H	11.0	Publications
13	REXO1L1	REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1	11.0
14	LAG3	lymphocyte-activation gene 3	11.0	Publications
15	C6orf25	chromosome 6 open reading frame 25	11.0	Publications
16	CD81	CD81 molecule	11.0	Publications
17	CD27	CD27 molecule	11.0	Publications
18	C1QBP	complement component 1, q subcomponent binding protein	11.0	Publications
19	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
20	BIRC3	baculoviral IAP repeat containing 3	11.0	Publications
21	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
22	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	11.0	Publications
23	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
24	CXCL13	chemokine (C-X-C motif) ligand 13	11.0	Publications
25	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
26	GALK2	galactokinase 2	11.0
27	FN1	fibronectin 1	11.0	Publications
28	PLAT	plasminogen activator, tissue	11.0	Publications
29	NPPB	natriuretic peptide B	11.0	Publications
30	RIT2	Ras-like without CAAX 2	11.0
31	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
32	SELE	selectin E	11.0	Publications
33	TLR2	toll-like receptor 2	11.0	Publications
34	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
35	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
36	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
37	HSPA4	heat shock 70kDa protein 4	11.0	Publications
38	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	11.0	Publications
39	VWF	von Willebrand factor	11.0	Publications
40	BMP6	bone morphogenetic protein 6	11.0	Publications
41	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
42	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
43	F2	coagulation factor II (thrombin)	11.0	Publications
44	EPO	erythropoietin	11.0	Publications
45	ICAM1	intercellular adhesion molecule 1	11.0	Publications
46	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
47	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
48	IL4	interleukin 4	11.0	Publications
49	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
50	TNF	tumor necrosis factor	11.0	Publications

Pathways related to cryoglobulinemia according to GeneDecks:

(show top 50)    (show all 88)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.7	FASLG
2	RAR-Gamma-RXR-Alpha Degradation36	10.6	TNFSF13B, CXCL13
3	Bacterial infections in CF airways41	10.6	TLR2
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	BCL2, FASLG
5	Antigen processing and presentation20	9.8	HLA-DRB1, HLA-DQB1, HSPA4, HSP90AA1
6	NFAT Signaling and Lymphocyte Interactions36	9.2	BCL2, TNFSF13B, BMP6, IL4, CCL2
7	Intestinal immune network for IgA production20	9.1	HLA-DQB1, HLA-DRB1, CD40LG, IL4, IL10, TNFSF13B
8	Apoptosis and survival_Apoptotic TNF-family pathways41	9.0	TNF, BCL2, CD27, FASLG, FAS
9	Apoptosis and survival Apoptotic TNF-family pathways10	9.0	CD27, FASLG, FAS, TNF, BCL2
10	Immune System38	9.0	CD81, IFNG, MALT1, CD79A, ICAM1, VCAM1
11	PGC1Alpha Pathway36	9.0	BMP6, BCL2, IL1B, TNFSF13B, IL4
12	Molecular Mechanisms of Cancer36	9.0	BCL2, TNFSF13B, FN1, BMP6, CXCL13, BIRC3
13	LDL Oxidation in Atherogenesis36	9.0	IL1B, VCAM1, TNF, ICAM1, CCL2
14	Jak-STAT signaling pathway20	8.9	IL10, EPO, IFNA2, IFNA1, IL4, TSLP
15	Natural killer cell mediated cytotoxicity20	8.9	TNF, ICAM1, IFNG, IFNA1, IFNA2
16	IL-6 Pathway36	8.9	CXCL13, CXCL10, TNFSF13B, CCL2, IL4, IL10
17	Apoptosis Signaling Pathways37	8.9	HSP90AA1, TNF, BIRC3, BCL2, FASLG, FAS
18	Asthma20	8.8	CD40LG, IL10, IL4, HLA-DQB1, HLA-DRB1, TNF
19	Autoimmune thyroid disease20	8.8	HLA-DRB1, CD40LG, IL10, IL4, FASLG, FAS
20	Endothelin-1 Signaling Pathway36	8.7	TNFSF13B, IL4, CXCL13, BMP6, IL10, CXCL10
21	Akt Signaling36	8.4	CXCL10, TNFSF13B, CCL2, IL4, HSP90AA1, IL10
22	Apoptosis20	8.4	BCL2, IL1B, FASLG, BIRC3, TNF, FAS
23	Hematopoietic cell lineage20	8.4	EPO, CD5, IL1B, IL4, HLA-DRB1, TNF
24	ERK Signaling36	8.4	CXCL10, BMP6, TNFSF13B, IL4, IL1B, IL10
25	Measles20	8.2	IFNG, IFNA2, MX1, IL1B, IL4, FASLG
26	Type I diabetes mellitus20	8.1	TNF, HLA-DRB1, HLA-DQB1, IFNG, FAS, FASLG
27	THC Differentiation Pathway36	8.0	HLA-DQB1, IFNG, IL4, IL10, TNF, HLA-DRB1
28	Cytokine Network36	7.9	IL4, TNF, IFNG, IFNA2, IFNA1, IL1B
29	Glucocorticoid Receptor Signaling36	7.8	CCL2, HSP90AA1, IL4, IL1B, TNFSF13B, IL10
30	Rho Family GTPases36	7.7	BCL2, IL1B, IL4, TNFSF13B, BMP6, CXCL10
31	SOCS Pathway36	7.7	IL1B, TNFSF13B, CCL2, IL4, IL10, BCL2
32	Toxoplasmosis20	7.6	BIRC3, TNF, HLA-DQB1, IFNG, IL10, CD40LG
33	Rheumatoid arthritis20	7.6	HLA-DQB1, IL1B, ICAM1, CCL2, IFNG, HLA-DRB1
34	Allograft rejection20	7.6	IL10, IL4, FASLG, FAS, CD40LG, HLA-DQB1
35	MIF Mediated Glucocorticoid Regulation36	7.4	CXCL13, BMP6, BCL2, IL10, IL1B, CXCL10
36	MIF Regulation of Innate Immune Cells36	7.4	BCL2, IL10, IL1B, IL4, BMP6, TNF
37	all-trans-Retinoic Acid Signaling in Brain36	7.4	TNFSF13B, CCL2, CXCL10, CXCL13, IL10, BCL2
38	PEDF Induced Signaling36	7.4	CXCL13, IL10, BCL2, BMP6, CCL2, IL4
39	Chagas disease (American trypanosomiasis)20	7.4	FAS, FASLG, IL10, CCL2, IFNG, TNF
40	STAT3 Pathway36	7.4	BCL2, CXCL10, BMP6, TNFSF13B, TNF, CCL2
41	PAK Pathway36	7.3	IL10, TNF, CXCL13, BMP6, TNFSF13B, CCL2
42	African trypanosomiasis20	7.3	IL1B, VCAM1, SELE, IFNG, FAS, IL10
43	Antioxidant Action of Vitamin-C36	7.2	BCL2, IL1B, TNF, BMP6, IL10, IL4
44	p38 Signaling36	7.1	CXCL13, CXCL10, TNFSF13B, BCL2, IL10, IL1B
45	Influenza A20	7.1	FASLG, IL1B, CCL2, IFNA1, IFNA2, IFNG
46	Leishmaniasis20	7.0	TLR2, IL10, IL1B, IL4, IFNG, HLA-DQB1
47	Malaria20	6.7	IL1B, IL10, CD40LG, CD81, VCAM1, CCL2
48	Tuberculosis20	6.7	TLR2, BCL2, IL10, IL1B, MALT1, IFNA1
49	JAK-STAT Pathway36	6.6	BCL2, F2, IFNG, IFNA2, IFNA1, CCL2
50	Cytokine-cytokine receptor interaction20	6.2	IFNA2, CCL2, FAS, FASLG, CD27, CD40LG

Compounds related to cryoglobulinemia according to GeneDecks:

(show top 50)    (show all 335)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.5	APOH, NPPB
2	ivig32	10.4	VWF, FASLG
3	polyethylene glycol32	10.3	IFNA2, FN1, SELE
4	endotoxin32	10.0	APOH, FASLG, CR1, CXCL10, SLC17A5
5	aspartate32	9.8	CD40LG, FASLG, ENO1, F2, HLA-DQB1, SLC17A5
6	n acetylcysteine32	9.7	VWF, SELE, VCAM1, CD79A, GPT, F2
7	heparin32 9 18 9	12.5	VWF, CD79A, FN1, F2, CR1, C1QBP
8	pge232	9.5	SELE, VCAM1, FN1, FASLG, HSP90AA1, TLR2
9	hyaluronic acid32 18	10.4	SLC17A5, F2, GPT, BMP6, FASLG, FN1
10	rituximab32 34 9 9	12.3	TNFSF13B, FASLG, BCL2, BCR, CD79A, CD40LG
11	fibrinogen32	8.4	SLC17A5, VCAM1, CD79A, MMP7, FN1, ENO1
12	okt332	8.4	SELE, VCAM1, BMP6, CD79A, CD40LG, IL10
13	creatinine32	8.3	CXCL10, NPPB, EPO, TNFSF13B, HSPA4, CCL2
14	histamine32 18	9.1	CCL2, IFNA2, ICAM1, PLAT, TLR2, CXCL10
15	ribavirin32 34 9 9	10.9	MX1, CD81, CD40LG, IL10, IL4, GPT
16	sb 20358032 42	8.8	SELE, VCAM1, BMP6, BIRC3, BCL2, IFNG
17	imiquimod32 42 9 9	10.7	MX1, BMP6, IFNA2, IL10, FASLG, IFNA1
18	poly(i-c)32	7.6	IFNA1, MX1, CXCL10, TLR2, TNF, IFNG
19	vegf32	7.5	VWF, SELE, VCAM1, BCL2, CD40LG, MMP7
20	alanine32	7.5	VWF, SELE, VCAM1, BMP6, BIRC3, MX1
21	rantes32	7.4	IFNA1, IFNG, ICAM1, TLR2, CXCL10, CCL2
22	cyclosporin a32 42	8.4	VWF, FN1, IL10, IL4, FASLG, GPT
23	ly29400232	7.4	IL1B, IL4, FASLG, CCL2, ICAM1, TNF
24	troglitazone32 42 9 9	10.4	PLAT, TNF, ICAM1, GPT, CCL2, IL1B
25	thalidomide32 42 9 9	10.3	BIRC3, CD40LG, IL10, IL1B, FASLG, IFNA1
26	infliximab32 9 9	9.3	IL4, APOH, FAS, IFNA2, IFNG, TNF
27	polyinosinic-polycytidylic acid32	7.3	TNF, TLR2, CXCL10, IFNG, IFNA1, IL4
28	atorvastatin32 34 9 18 9	11.2	SLC17A5, NPPB, PLAT, VWF, SELE, VCAM1
29	il-1232	7.1	TNF, CCL2, IFNA1, IFNG, CD40LG, IL4
30	methotrexate32 34 42 9 9	11.0	IL10, SELE, BMP6, IL1B, APOH, CD79A
31	prostacyclin32	7.0	VWF, SELE, VCAM1, BMP6, FN1, IL10
32	prednisolone32 9 9	8.9	VWF, VCAM1, BMP6, CD79A, IL10, FAS
33	lactate32	6.9	EPO, SLC17A5, ICAM1, BMP6, CD79A, CD40LG
34	neopterin32	6.9	MX1, CD79A, CD40LG, IL10, IL1B, IL4
35	tacrolimus32 34 9 9	9.9	BMP6, CD79A, FN1, IL10, IL4, FASLG
36	indomethacin32 9 9	8.8	BMP6, IL4, NPPB, PLAT, TNF, CD79A
37	phosphatidylinositol32	6.8	NPPB, EPO, CXCL10, BCL2, BCR, CD81
38	paraffin32	6.7	IL4, FASLG, FAS, MALT1, CCL2, HSPA4
39	gm-csf32	6.6	IL1B, ICAM1, IL4, IFNG, IL10, EPO
40	herbimycin a32 42	7.4	FN1, IL1B, IL4, FAS, CCL2, IFNG
41	polymyxin b32	6.4	SELE, VCAM1, IL10, IL1B, IL4, CCL2
42	nitric oxide32 9 18 9	9.4	IL10, IFNG, TLR2, NPPB, CR1, CCL2
43	genistein32 9 18 9	9.1	HSP90AA1, HSPA4, TNF, CXCL10, NPPB, ICAM1
44	tyrosine32	6.0	BMP6, VCAM1, BIRC3, BCR, CD81, CD5
45	simvastatin32 34 42 9 18 9	11.0	VWF, SELE, VCAM1, BMP6, IL10, IL4
46	actinomycin d32	5.8	NPPB, TLR2, PLAT, TNF, SELE, BIRC3
47	thymidine32 18	6.5	IL1B, NPPB, TNFSF13B, IFNG, IFNA2, CXCL10
48	retinoic acid32 42 18	7.2	VWF, VCAM1, BMP6, BCL2, CD79A, CD40LG
49	dexamethasone32 42 34 9 9	8.4	VWF, HSPA4, TNF, TLR2, CXCL10, NPPB
50	cycloheximide32	4.2	TLR2, SELE, HSPA4, TNF, CR1, PLAT

Cellular components related to cryoglobulinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	8.2	HLA-DRB1, TNF, CR1, TLR2, ICAM1, FASLG
2	external side of plasma membrane	GO:009897	6.6	CXCL10, CD27, CD79A, LAG3, VCAM1, VWF
3	extracellular region	GO:005576	6.3	IFNG, F2, PLAT, CXCL10, CXCL13, NPPB
4	plasma membrane	GO:005886	6.1	HSP90AA1, HLA-DQB1, HLA-DRB1, TNF, TNFSF13B, CR1
5	extracellular space	GO:005615	4.2	EPO, NPPB, CXCL13, CXCL10, TSLP, C1QBP

Biological processes related to cryoglobulinemia according to GeneDecks:

(show all 42)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation, intrinsic pathway	GO:007597	10.2	VWF, APOH, F2, C1QBP
2	leukocyte cell-cell adhesion	GO:007159	10.1	SELE, VCAM1, CD40LG, ICAM1
3	inflammatory cell apoptotic process	GO:006925	10.0	FAS, FASLG
4	negative regulation of angiogenesis	GO:016525	10.0	NPPB, CXCL10, CCL2, FASLG, APOH
5	leukocyte tethering or rolling	GO:050901	9.9	SELE, VCAM1, TNF
6	regulation of immune response	GO:050776	9.7	ICAM1, IL4, CD40LG, CD81, VCAM1
7	response to lipopolysaccharide	GO:032496	9.7	EPO, CXCL10, FAS, FASLG, SELE
8	B cell proliferation	GO:042100	9.6	BCL2, CD79A, CD40LG, IL10
9	induction of apoptosis via death domain receptors	GO:008625	9.6	TNF, FAS, FASLG
10	B cell differentiation	GO:030183	9.5	IL4, IL10, CD40LG, CD79A, VCAM1
11	regulation of isotype switching	GO:045191	9.5	IL4, IL10
12	positive regulation of NF-kappaB import into nucleus	GO:042346	9.4	TLR2, TNF, IL1B
13	positive regulation of interleukin-12 production	GO:032735	9.4	CD40LG, IFNG, TLR2
14	induction of apoptosis	GO:006917	9.4	TLR2, TNF, IFNA2, FAS, FASLG, CD27
15	response to gamma radiation	GO:010332	9.4	CXCL10, CCL2, IL1B, BCL2
16	lipopolysaccharide-mediated signaling pathway	GO:031663	9.3	IL1B, CCL2, TNF, TLR2
17	positive regulation of vitamin D biosynthetic process	GO:060557	9.2	TNF, IFNG
18	aging	GO:007568	9.2	EPO, CCL2, FAS, IL1B, VCAM1
19	response to heat	GO:009408	9.2	BCL2, IL1B, CCL2, HSPA4
20	response to ethanol	GO:045471	9.2	ICAM1, CCL2, IL4, CD27, BCL2
21	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	IL1B, MALT1, ICAM1, TNF, TLR2
22	interferon-gamma-mediated signaling pathway	GO:060333	9.1	HLA-DRB1, HLA-DQB1, ICAM1, IFNG, VCAM1
23	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.0	TNF, IFNG, IL1B
24	positive regulation of MHC class II biosynthetic process	GO:045348	9.0	IFNG, IL4, IL10, CD40LG
25	positive regulation of membrane protein ectodomain proteolysis	GO:051044	8.9	TNF, IFNG, IL1B
26	immune response	GO:006955	8.9	CXCL13, CXCL10, TLR2, C1QBP, TNFSF13B, HLA-DRB1
27	positive regulation of T cell proliferation	GO:042102	8.8	IFNG, IL4, IL1B, VCAM1
28	cell surface receptor signaling pathway	GO:007166	8.8	NPPB, CXCL10, F2, IFNG, IFNA2, CCL2
29	cell-cell signaling	GO:007267	8.7	CXCL13, CXCL10, IFNA2, FASLG, IL1B, IL10
30	negative regulation of growth of symbiont in host	GO:044130	8.7	IL10, IFNG, TNF, TLR2
31	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	8.7	TNF, MALT1, FASLG, IL1B, BIRC3
32	humoral immune response	GO:006959	8.6	BCL2, CCL2, IFNG, TNF
33	positive regulation of chemokine biosynthetic process	GO:045080	8.6	TNF, IFNG, IL4, IL1B
34	cellular response to lipopolysaccharide	GO:071222	8.6	ICAM1, IFNG, CCL2, IL10
35	response to glucocorticoid stimulus	GO:051384	8.4	PLAT, TNF, CCL2, FAS, IL1B, IL10
36	positive regulation of nitric oxide biosynthetic process	GO:045429	8.3	TLR2, TNF, HSP90AA1, ICAM1, IFNG, IL1B
37	response to hypoxia	GO:001666	8.3	NPPB, PLAT, TNF, CCL2, FAS, IL1B
38	signal transduction	GO:007165	8.1	EPO, RIT2, CXCL13, CXCL10, TLR2, TNFSF13B
39	cytokine-mediated signaling pathway	GO:019221	8.1	HLA-DRB1, HLA-DQB1, ICAM1, IFNG, IFNA2, CCL2
40	inflammatory response	GO:006954	7.9	TNF, TLR2, CXCL10, NPPB, IFNA2, CCL2
41	anti-apoptosis	GO:006916	7.5	BIRC3, EPO, TNF, CCL2, MALT1, FAS
42	response to drug	GO:042493	6.8	IFNG, ICAM1, TNF, NPPB, CCL2, FAS

Molecular functions related to cryoglobulinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:008201	9.7	FN1, APOH, CCL2, C6orf25, CXCL13
2	transmembrane signaling receptor activity	GO:004888	9.5	TLR2, ICAM1, CD5, CD27, CD79A, LAG3
3	tumor necrosis factor receptor binding	GO:005164	9.5	TNFSF13B, TNF, FASLG, CD40LG
4	protease binding	GO:002020	8.8	TNF, MALT1, BCL2, VWF
5	cytokine activity	GO:005125	6.9	BMP6, TSLP, TNFSF13B, TNF, IFNG, IFNA2
6	protein binding	GO:005515	5.3	ENO1, MALT1, IFNA2, ICAM1, F2, HSP90AA1