MCID: CRY004
MIFTS: 57

Cryoglobulinemia malady

Rare diseases, Immune diseases categories
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Summaries for Cryoglobulinemia

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis c and vasculitis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Antigen Activates B Cell Receptor Leading to Generation of Second Messengers. The drugs interferon alfa-2a and interferon alfa-2b and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:65 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

cryoglobulinemia 8 43 10 45 62
cryoimmunoglobulinaemia 8


External Ids:

Disease Ontology8 DOID:2917
NCIt40 C26736
SNOMED-CT58 30911005
MeSH35 D003449

Related Diseases for Cryoglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.6CD40LG, IFNA2
2vasculitis31.0IGHM, APOH, CD79A, CD40LG, IFNA2
3glomerulonephritis30.9TSLP, CD79A, CD40LG
4membranoproliferative glomerulonephritis30.7IFNA2, CD79A, TSLP
5hepatitis b30.6IFNA2, IGHM, CD79A
6purpura30.5CD79A
7macroglobulinemia30.5CD5, CD79A
8b-cell lymphomas30.4CD5, IGHM, BCR
9myeloma30.4IGHM, IFNA2, BCR, CD79A, CD40LG
10cryoglobulinemic vasculitis30.3IGHM, CD40LG, CD5, IFNA2, TSLP, BCR
11leukemia30.3CD79A, CD40LG, CD5, IFNA2, BCR
12lupus erythematosus30.3CD79A, APOH, CD40LG
13chronic lymphocytic leukemia30.2BCR, IGHM, CD40LG, CD5
14q fever30.2CD79A
15systemic lupus erythematosus30.1CD79A, IGHM, APOH, BCR, CD40LG
16malt lymphoma30.1IGHM, CD5
17rheumatoid arthritis30.0IGHM, APOH, CD79A, CD40LG, CD5
18polyneuropathy30.0IFNA2, CD79A, CD40LG
19nephritis30.0APOH, CD40LG, CD79A
20polyarteritis nodosa29.9IFNA2
21viral hepatitis29.9IFNA2
22thrombocytopenia29.9CD40LG, CD79A, APOH, IFNA2
23retinal vasculitis29.9APOH
24hairy cell leukemia29.9CD5, IFNA2
25macroglobulinemia, waldenstrom, somatic29.9CD40LG, IGHM
26antiphospholipid syndrome29.8CD79A, APOH, CD40LG
27hepatitis11.1
28hepatitis c virus11.0
29type ii mixed cryoglobulinemia10.7
30neuropathy10.4
31peripheral neuropathy10.4
32hodgkin's lymphoma10.4
33multiple myeloma10.4
34liver disease10.3
35thyroiditis10.3
36arthritis10.3
37autoimmune thyroiditis10.2
38cold agglutinin disease10.2
39ischemia10.2
40non-hodgkin lymphoma10.2
41scleritis10.2
42mixed cryoglobulinemia type iii10.2
43dysentery10.1CD79A
44chickenpox10.1CD79A
45agammaglobulinemia 310.1CD79A
46mumps10.1CD79A
47cerebritis10.1
48rapidly progressive glomerulonephritis10.1
49proliferative glomerulonephritis10.1
50lymphoplasmacytic lymphoma10.1

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Cryoglobulinemia:

33
Skin, B cells, Liver, Kidney, Thyroid, Bone, Bone marrow, Brain, Endothelial, T cells, Lung, Lymph node, Testes, Nk cells, Monocytes, Colon, Smooth muscle, Heart, Whole blood, Small intestine

Animal Models for Cryoglobulinemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cryoglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5BCR, CD79A, CD40LG, IGHM
2MP:00053977.7IGHM, TSLP, BCR, CD5, CD79A, CD40LG
3MP:00053877.6IGHM, TSLP, BCR, CD5, CD79A, CD40LG
4MP:00053767.0CD79A, BCR, TSLP, APOH, IGHM, CD40LG

Publications for Cryoglobulinemia

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Sources:
52PubMed
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Articles related to Cryoglobulinemia:

(show top 50)    (show all 742)
idTitleAuthorsYear
1
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
2
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
3
The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)
2011
4
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
5
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
6
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
7
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
8
Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)
2010
9
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
10
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
11
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
12
Cryoglobulinemia and renal disease. (18408474)
2008
13
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
14
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
15
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)
2008
16
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
17
Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)
2007
18
Cryoglobulinemia. (17289231)
2007
19
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
20
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
21
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
22
Images in clinical medicine. Mixed cryoglobulinemia. (15972869)
2005
23
Successful treatment of necrotizing vasculitic lesions after infusion of iloprost in a patient with cryoglobulinemia and chronic HCV infection. (16396716)
2005
24
Autoamputation in a patient with cryoglobulinemia. (15468383)
2004
25
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
26
HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)
2003
27
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
28
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
29
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
30
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
31
Cryoglobulinemia. (10626153)
1999
32
Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)
1999
33
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
34
Exacerbation of peripheral neuropathy during alpha-interferon therapy in a patient with mixed cryoglobulinemia and hepatitis B virus infection. (8877939)
1996
35
Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)
1995
36
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
37
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
38
The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)
1994
39
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
40
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
41
Association between hepatitis C virus and mixed cryoglobulinemia. (1656512)
1991
42
Cryoglobulinemia type II]. (2074925)
1990
43
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
44
Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)
1986
45
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
46
Synovial fluid in mixed cryoglobulinemia. (737009)
1978
47
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978
48
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
49
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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50PathCards, 30KEGG, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database
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Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, CD79A
2
Show member pathways
9.3CD79A, IGHM
38.9CD79A, CD5, IGHM

Compounds for genes affiliated with Cryoglobulinemia

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 3BitterDB, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1sulfolipid i4510.0CD79A, CD40LG
2sandoglobulin4510.0CD40LG, CD79A
3vancomycin45 1111.0CD40LG, CD79A
4pneumococcal4510.0CD79A, CD40LG
5tuberculin4510.0CD40LG, CD79A
6chlorambucil45 1111.0CD40LG, IFNA2
7praziquantel45 1111.0CD40LG, CD79A
8hemocyanin4510.0CD40LG, CD79A
9fluorochrome459.9BCR, CD40LG
10gliadin459.9CD79A, CD40LG
11mizoribine459.9IFNA2, CD79A
12pmma459.9CD40LG, CD79A
13silicone459.9CD40LG, CD79A
14busulfan45 51 1111.8BCR, IFNA2
15mannan459.8CD79A, CD40LG
16isotretinoin45 1110.7IFNA2, CD79A
17allergens459.7TSLP, CD40LG, CD79A
18dapsone45 3 51 1112.6CD79A, IFNA2
19okt3459.6CD40LG, CD79A
20gamma globulin459.6CD79A, CD40LG, IFNA2
21neopterin459.6CD40LG, CD79A, IFNA2
22polyethylene glycol459.6IFNA2, CD40LG, CD79A
23thyroxine45 2410.5CD40LG, CD79A, IFNA2
24blys459.5CD79A, BCR, CD40LG
25gluten459.5APOH, CD79A
26con a459.5CD79A, IFNA2
27agar459.5CD79A, IFNA2, CD40LG
28epinephrine45 24 1111.4CD40LG, IFNA2, CD79A
29ascorbic acid45 2410.4CD40LG, CD79A, IFNA2
30indomethacin45 29 61 1112.4IFNA2, CD79A, CD40LG
31hydroxychloroquine45 1110.3CD40LG, IFNA2, APOH
32cardiolipin45 1110.2APOH, CD40LG, CD79A
33ivig459.2APOH, CD79A, CD40LG
34vitamin b12459.2CD79A, CD40LG, APOH
35folate459.2APOH, CD79A, CD40LG
36phosphatidylserine45 29 1111.1APOH, CD40LG, CD79A
37aspirin45 51 29 2412.1CD40LG, CD79A, APOH
38betacarotene459.1APOH, CD79A, IFNA2
39galactose459.1APOH, IFNA2, CD79A
40azathioprine45 3 51 1112.1CD79A, IFNA2, APOH
41prednisolone45 29 1111.1IFNA2, APOH, CD79A
42cyclophosphamide45 51 1111.1APOH, BCR, IFNA2
43sialic acid459.0CD79A, BCR, APOH
44fibrinogen458.9CD40LG, CD79A, APOH
45histamine45 29 2410.9CD40LG, CD79A, IFNA2
46vegf458.7CD40LG, IFNA2, CD79A, APOH
47heparin45 29 24 1111.7CD40LG, APOH, CD79A, BCR
48cysteine458.5CD40LG, BCR, IFNA2, CD79A
49estrogen458.4CD40LG, IFNA2, CD79A, APOH
50rituximab45 51 1110.3APOH, IFNA2, BCR, CD79A, CD40LG

GO Terms for genes affiliated with Cryoglobulinemia

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16Gene Ontology
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Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CD40LG, CD79A, CD5
2extracellular spaceGO:0056158.5CD40LG, IFNA2, TSLP, APOH

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.6CD40LG, CD79A
2B cell proliferationGO:0421009.3CD40LG, CD79A

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.3CD40LG, IFNA2, TSLP

Products for genes affiliated with Cryoglobulinemia

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Sources for Cryoglobulinemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet