MCID: CRY004
MIFTS: 61

Cryoglobulinemia malady

Summaries for Cryoglobulinemia

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis and hepatitis c. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Rheumatoid arthritis and Tuberculosis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds aspartate and ribavirin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:63 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cryoglobulinemia 8 42 10 44 60
cryoimmunoglobulinaemia 8


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Disease Ontology8 DOID:2917
NCIt39 C26736
SNOMED-CT56 30911005
MeSH34 D003449

Related Diseases for Cryoglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, CXCL10
2hepatitis c31.5IFNA2, IFNA1, TNFSF13B, FAS, HLA-DRB1, CD40LG
3vasculitis31.1ENO1, CD40LG, FN1, IGHM, APOH, TNFSF13B
4glomerulonephritis30.8TSLP, CD40LG, FN1
5hepatitis b30.8IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, CXCL10
6membranoproliferative glomerulonephritis30.6TSLP, IFNA2
7myeloma30.5IFNA2, IFNA1, TNFSF13B, FAS, FASLG, IGHM
8thyroiditis30.4HLA-DRB1, FASLG, IFNA1
9cryoglobulinemic vasculitis30.4IFNA2, BCR, TSLP, ENO1, CD40LG, CD5
10arthritis30.3HLA-DRB1, FN1, CXCL10
11autoimmune hepatitis30.3IFNA1, FAS, HLA-DQB1, HLA-DRB1, CD40LG
12leukemia30.3CD27, CD40LG, CD5, FN1, HLA-DRB1, FASLG
13macroglobulinemia30.3CD5
14systemic lupus erythematosus30.2CD27, TNFSF13B
15lupus erythematosus30.2IFNA2, APOH
16chronic lymphocytic leukemia30.2BCR, CD27, CD40LG, CD5, IGHM, TNFSF13B
17rheumatoid arthritis30.2HLA-DRB1, HLA-DQB1, FASLG, FAS, APOH, TNFSF13B
18viral hepatitis30.1IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, FN1
19non-hodgkin lymphoma30.1TNFSF13B, FAS, HLA-DRB1, CD5, CD27, BCR
20liver cirrhosis30.0IFNA2, IFNA1, HLA-DRB1, CXCL10
21endocarditis29.9FN1
22polyneuropathy29.9CD40LG, IFNA2
23thrombocytopenia29.9IFNA2, IFNA1, APOH, CD40LG
24hepatocellular carcinoma29.9IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, FN1
25polyarteritis nodosa29.7IFNA2
26pneumonia29.7CXCL10
27encephalitis29.7CXCL10, IFNA1
28macroglobulinemia, waldenstrom, somatic29.7CD40LG, IGHM
29antiphospholipid syndrome29.7CD40LG, APOH
30uveitis29.7CXCL10, CXCL11, IFNA2
31influenza29.7IFNA1, CD27, CXCL10
32hepatitis e29.7CD40LG
33hairy cell leukemia29.7CD5, IFNA1, IFNA2
34psoriasis29.7HLA-DRB1, FN1, CXCL10
35mycosis fungoides29.7IFNA2, IFNA1, CXCL11, CXCL10
36bronchiolitis obliterans29.7CXCL10
37lymphopenia29.7FAS, FASLG
38systemic scleroderma29.7TNFSF13B, APOH, HLA-DQB1, HLA-DRB1, CD40LG
39adenocarcinoma29.7FAS, FASLG, CXCL10, MMP7, ENO1
40retinal vasculitis29.7APOH
41periodontal disease29.7MMP7, CXCL10, FN1
42hepatitis a10.6
43neuropathy10.4
44peripheral neuropathy10.3
45hodgkin's lymphoma10.3
46multiple myeloma10.3
47liver disease10.3
48autoimmune thyroiditis10.2
49purpura10.2
50ischemia10.1

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Clinical Features for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cryoglobulinemia

Drug clinical trials:

Search ClinicalTrials for Cryoglobulinemia

Search NIH Clinical Center for Cryoglobulinemia

Search CenterWatch for Cryoglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Cryoglobulinemia:

32
Skin, B cells, Liver, Kidney, Thyroid, Bone, Brain, Bone marrow, Endothelial, T cells, Testes, Lymph node, Lung, Heart, Smooth muscle, Monocytes, Nk cells, Small intestine, Whole blood, Colon

Animal Models for Cryoglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cryoglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9APOH, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
2MP:00053859.9FASLG, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
3MP:00053819.9FAS, FASLG, HLA-DQB1, IGHM, MMP7, TSLP
4MP:00053979.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
5MP:00053849.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
6MP:00053879.7BCR, TNFSF13B, FAS, FASLG, HLA-DQB1, IGHM
7MP:00107689.4APOH, FAS, FASLG, HLA-DQB1, IGHM, FN1

Publications for Cryoglobulinemia

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50PubMed
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Articles related to Cryoglobulinemia:

(show top 50)    (show all 751)
idTitleAuthorsYear
1
Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2. (23559389)
2013
2
An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature. (22895834)
2013
3
High serum levels of CXCL11 in mixed cryoglobulinemia are associated with increased circulating levels of interferon-I^. (21724697)
2011
4
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
5
Long-term efficacy of rituximab in hepatitis C virus-associated cryoglobulinemia. (19705122)
2010
6
Adult perniosis and cryoglobulinemia: a retrospective study and review of the literature. (20466166)
2010
7
Safety and efficacy of rituximab in nonviral cryoglobulinemia vasculitis: data from the French Autoimmunity and Rituximab registry. (20740617)
2010
8
Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab. (19097173)
2009
9
WaldenstrAPm's macroglobulinemia: hyperviscosity syndrome and cryoglobulinemia. (19362986)
2009
10
Hepatitis C virus-induced cryoglobulinemia. (19606079)
2009
11
Mixed cryoglobulinemia syndrome as an additional autoimmune disorder associated with risk for lymphoma development. (18544704)
2008
12
Relapse of hepatitis C virus-associated mixed cryoglobulinemia vasculitis in patients with sustained viral response. (18240235)
2008
13
Increased risks of lymphoma and death among patients with non-hepatitis C virus-related mixed cryoglobulinemia. (17060540)
2006
14
Interferon/pegylated interferon and ribavirin in HCV-associated kidney disease with or without cryoglobulinemia. (16338023)
2006
15
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
16
Life-threatening cryoglobulinemia in HCV-negative Southern Chinese and a novel association with structural aortic abnormalities. (15503020)
2005
17
Cryoglobulinemia in kidney transplant recipients. (16387095)
2005
18
Initial increase in the cryoglobulin level after rituximab therapy for type II cryoglobulinemia secondary to WaldenstrAPm macroglobulinemia does not indicate failure of response. (15551276)
2004
19
Enhanced TH1 cytokine production in hepatitis C virus-infected patients with mixed cryoglobulinemia: understanding the pathological issues. (15582141)
2004
20
bcl-2 rearrangement in mixed cryoglobulinemia. (12899594)
2003
21
Influence of age and autoimmunity on liver disease in HCV-associated type II mixed cryoglobulinemia. (12175729)
2002
22
Intravenous interferon-alpha treatment of mixed cryoglobulinemia associated with chronic hepatitis C virus infection. (12175119)
2002
23
Type I cryoglobulinemia presenting as hemorrhagic crusted leg ulcers. (12502119)
2002
24
Gallbladder vasculitis associated with type-1 cryoglobulinemia. (11281178)
2001
25
Mixed cryoglobulinemia and hepatitis C virus association: ten years later. (11433637)
2001
26
Biclonal gammopathy and platelet antibodies in a patient with chronic hepatitis C virus infection and mixed cryoglobulinemia. (10985369)
2000
27
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
28
Cryoglobulinemia. (10626153)
1999
29
Clinical image: cutaneous ulceration in type II cryoglobulinemia. (9588739)
1998
30
A case of mixed monoclonal cryoglobulinemia leading to the diagnosis of lymphoma in a patient with primary SjAPgren's syndrome. (9808406)
1998
31
Renal involvement in essential monoclonal (type 1) IgG cryoglobulinemia. (9776430)
1998
32
Guidelines for the management of essential mixed cryoglobulinemia. (8730505)
1995
33
Localization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus-infected patients with mixed cryoglobulinemia. (7843698)
1995
34
A role for chronic hepatitis C virus infection in a patient with cutaneous vasculitis, cryoglobulinemia, and chronic liver disease. Effective therapy with interferon-alpha. (7781436)
1995
35
Pemphigus vulgaris with cryoglobulinemia and cold agglutinin disease. (7829446)
1994
36
Hepatitis C virus antibodies in mixed cryoglobulinemia. (1711426)
1991
37
Cryoglobulinemia type II]. (2074925)
1990
38
Fatal pneumocystosis complicating essential mixed cryoglobulinemia. (3139520)
1988
39
Persistent Epstein-Barr virus infection in patients with type II essential mixed cryoglobulinemia. (2836115)
1988
40
Clinical significance of cross-linked fibrin degradation products in essential mixed cryoglobulinemia. (3240365)
1988
41
Analysis of serum immune complexes isolated from patients with essential mixed cryoglobulinemia. (3311079)
1987
42
Case 40-1984: essential mixed cryoglobulinemia and chronic persistent hepatitis. (3871248)
1985
43
Essential mixed cryoglobulinemia: clinical and immunological studies. (6746538)
1984
44
Acute renal failure in essential mixed cryoglobulinemia: precipitation and reversal by plasma exchange. (6733996)
1984
45
Plasmapheresis as sole therapy in a patient with essential mixed cryoglobulinemia. (6741940)
1984
46
Immune complexes and complement profile in essential mixed cryoglobulinemia before and after plasma exchange. (6642740)
1983
47
Pancytopenia with mixed cryoglobulinemia: evidence for anti-percursor cell activity of cryoglobulin--effects of plasmapheresis. (7096545)
1982
48
Idiopathic mixed cryoglobulinemia in two sisters. (6785977)
1981
49
Mixed cryoglobulinemia: association of glomerulonephritis with defective reticuloendothelial system Fc receptor function. (549248)
1979
50
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978

Genetic Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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29KEGG, 53Reactome, 12EMD Millipore, 52R&D Systems, 55SinoBiological, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4TNFSF13B
210.3HLA-DRB1, HLA-DQB1
310.3FASLG, FAS
4
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10.3FASLG, FAS
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.2IFNA2, IFNA1, FN1
6
Apoptosis and survival Apoptotic TNF-family pathways
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10.2FAS, FASLG, CD27
710.2CXCL10, IFNA1, IFNA2
810.2CXCL10, CXCL11, FN1
9
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10.2IFNA2, IFNA1, HLA-DQB1, HLA-DRB1
10
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10.1IGHM, FASLG, FAS, IFNA1, IFNA2
11
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10.1IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, IGHM, CD40LG
12
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10.0TNFSF13B, FAS, FASLG, HLA-DQB1, CD40LG, CD27
13
Hide members
10.0IFNA2, IFNA1, FAS, FASLG, CXCL11, CXCL10
14
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9.9IFNA2, IFNA1, FAS, FASLG, HLA-DQB1, HLA-DRB1
15
Hide members
9.9CD40LG, IFNA2, IFNA1, TNFSF13B, FAS, FASLG
16
Hide members
9.8IFNA1, TNFSF13B, FAS, FASLG, CD27, CXCL11

Compounds for genes affiliated with Cryoglobulinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1aspartate4410.8CD40LG, FASLG
2ribavirin44 49 1112.8IFNA2, CD40LG
3ivig4410.7CD40LG, APOH
4hydroxychloroquine44 1111.7IFNA2, APOH, CD40LG
5infliximab44 49 1112.7IFNA2, APOH, CXCL10
6gliadin4410.7CD40LG
7blys4410.6TNFSF13B, CD40LG, BCR
8atpo44 2811.6IFNA1, APOH, FAS, FASLG
9serine4410.6BCR, FN1
102-chlorodeoxyadenosine4410.6IFNA1, FAS, FASLG, CD40LG
11dextran sulfate4410.6MMP7, CD40LG, FN1, APOH
12fludarabine44 1111.6CD40LG, FASLG, FAS, IFNA1
13indomethacin44 59 28 1113.6FN1
14agar4410.6FN1, FASLG, FAS
15busulfan44 1111.6IFNA2, IFNA1, BCR
16allergens4410.6HLA-DRB1, CD40LG, CXCL10, TSLP
17neopterin4410.5CXCL10, CD40LG, IFNA1, IFNA2
18cytarabine44 49 1112.5BCR, FASLG, FAS, IFNA1, IFNA2
19teniposide44 1111.5IFNA1, FAS, FASLG
20cyclophosphamide44 49 1112.5IFNA2, IFNA1, APOH, FASLG, BCR
21ifn-alpha4410.5IFNA2, IFNA1, FAS, FASLG, CXCL10
22rantes4410.5IFNA1, FAS, FASLG, CD40LG, CXCL11
23cyclosporin a44 28 5912.5IFNA1, FN1, CD40LG, CXCL11
24thalidomide44 49 59 1113.5IFNA2, IFNA1, FASLG, CD40LG
25creatinine4410.5TNFSF13B, APOH, FAS, CXCL10, ENO1
26rituximab44 49 1112.4BCR, CD40LG, FASLG, APOH, TNFSF13B, IFNA1
27paraffin4410.4FAS, FASLG, FN1, CD5, CD40LG, MMP7
28genistein44 28 59 2 11 2415.4FAS, FASLG, FN1, CD40LG, CXCL10, BCR
29polyethylene glycol4410.4IFNA2, IFNA1, FN1, CD40LG
30pegasys4410.4IFNA1, IFNA2
31doxorubicin44 49 1112.4IFNA2, IFNA1, FAS, FASLG, FN1, CD40LG
32lactate4410.4APOH, FAS, FASLG, FN1, CD40LG, ENO1
33imiquimod44 28 59 1113.4IFNA2, IFNA1, FASLG
34dexamethasone44 49 28 1113.4IFNA1, FAS, FASLG, FN1, CD40LG, CXCL11
35cisplatin44 49 59 1113.3IFNA2, IFNA1, FAS, FASLG, FN1, CD40LG
36thymidine44 2411.3IFNA2, IFNA1, TNFSF13B, FAS, FASLG, FN1
37phosphatidylinositol4410.3APOH, FAS, FASLG, FN1, CXCL10, MMP7
38oligonucleotide4410.3FAS, FASLG, HLA-DQB1, HLA-DRB1, CXCL11, MMP7
39alanine4410.3IFNA2, IFNA1, TNFSF13B, FASLG, HLA-DRB1, FN1
40heparin44 28 11 2413.3APOH, FAS, FASLG, FN1, CD40LG, BCR
41cysteine4410.3IFNA2, FAS, FASLG, FN1, CD40LG, CD27
42vegf4410.2IFNA2, IFNA1, APOH, FAS, FASLG, FN1
43retinoic acid44 2411.2IFNA2, IFNA1, FAS, FASLG, FN1, CD40LG
44arginine4410.2APOH, FAS, HLA-DRB1, FN1, CD40LG, CXCL11
45thymidylate4410.2IFNA2, IFNA1, FAS, FASLG
46adriamycin4410.2FN1, FASLG, FAS, IFNA1
47prednisolone44 28 1112.1IFNA2, IFNA1, APOH, FAS
48tyrosine4410.0IFNA2, IFNA1, FAS, FASLG, HLA-DQB1, HLA-DRB1
49calcium44 49 11 2412.9TNFSF13B, APOH, FASLG, CD5, CD27, CXCL11
50fibrinogen449.8APOH, FN1, CD40LG, MMP7, ENO1

GO Terms for genes affiliated with Cryoglobulinemia

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16Gene Ontology
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Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9CXCL10, FAS, FASLG, HLA-DRB1, CD5, CD40LG
2extracellular regionGO:0055769.8FAS, FASLG, IGHM, FN1, CD27, CXCL11
3extracellular spaceGO:0056159.4IFNA2, TNFSF13B, APOH, FASLG, FN1, CD40LG

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FASLG, FAS
2immunoglobulin secretionGO:04830510.6CD40LG, TNFSF13B
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB1, HLA-DQB1
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DQB1, HLA-DRB1
5positive regulation of endothelial cell apoptotic processGO:200035310.5CD40LG, FASLG
6negative regulation of angiogenesisGO:01652510.5APOH, FASLG, CXCL10
7T cell costimulationGO:03129510.4TNFSF13B, HLA-DQB1, HLA-DRB1, CD5
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.3FAS, FASLG
9cell-cell signalingGO:00726710.2CXCL10, CXCL11, FASLG, IFNA2
10positive regulation of leukocyte chemotaxisGO:00269010.2CXCL11, CXCL10
11immune responseGO:00695510.2CXCL10, CXCL11, IGHM, HLA-DRB1, HLA-DQB1, FASLG
12inflammatory responseGO:00695410.2CXCL10, CXCL11, CD40LG, IFNA2
13signal transductionGO:0071659.7TNFSF13B, FAS, FASLG, CXCL11, CXCL10, BCR

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.3HLA-DRB1, HLA-DQB1
2tumor necrosis factor receptor bindingGO:00516410.2TNFSF13B, FASLG, CD40LG
3cytokine activityGO:00512510.1TSLP, CD40LG, FASLG, TNFSF13B, IFNA2
4protein bindingGO:0055159.2IFNA2, TNFSF13B, APOH, FAS, FASLG, MT1H

Products for genes affiliated with Cryoglobulinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet