MCID: CRY004
MIFTS: 46

Cryoglobulinemia malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

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Summaries for Cryoglobulinemia

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NIH Rare Diseases:48 Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to endocarditis and mesangial proliferative glomerulonephritis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics. The drugs interferon alfa-2b and recombinant interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:11 A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:71 Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1endocarditis29.7CD40LG, CD79A
2mesangial proliferative glomerulonephritis29.5CD40LG, CD79A
3homocystinuria29.5CD40LG, CD79A
4cryoglobulinemia, familial mixed12.2
5type ii mixed cryoglobulinemia11.9
6mixed cryoglobulinemia type iii11.9
7simple cryoglobulinemia11.8
8hepatitis c virus11.3
9hepatitis10.7
10hepatitis c10.7
11vasculitis10.4
12primary laryngeal lymphangioma10.3CXCL10, CXCL11
13amyotrohpic lateral sclerosis type 2210.3CD40LG, CXCL10
14paramyloidosis10.3CD40LG, CD5
15hyperparathyroidism, primary, caused by water clear cell hyperplasia10.3CD40LG, TNFSF13B
16dyskeratosis congenita10.3CD40LG, CXCL10
17alcoholic neuropathy10.3CD40LG, CD79A
18camptodactyly vertebral fusion10.3CD40LG, CD79A
19spinal polio10.3CD40LG, CD79A
20rabies10.3CD40LG, CD79A
21unilateral retinoblastoma10.3CD40LG, CD79A
22delta chain disease10.3CD40LG, CD79A
23discitis10.3CD40LG, CD79A
24spinal canal and spinal cord meningioma10.3CD40LG, CD79A
25trichostrongyloidiasis10.3CD40LG, CD79A
26colloid adenoma10.2CD40LG, CD79A
27heart septal defect10.2CD40LG, CD79A
28cutaneous polyarteritis nodosa10.2CD40LG, CD79A
29lymphoma10.2
30mild pre-eclampsia10.2CD40LG, CD79A
31retinal microaneurysm10.2CD40LG, CD79A
32pediatric meningioma10.2CD40LG, CD79A
33tonsil cancer10.2CD40LG, CD79A
34indomethacin antenatal infection10.2CD40LG, CD79A
35postcricoid region cancer10.2CD40LG, CD79A
36beach ear10.2CD40LG, CD79A
37acute kidney tubular necrosis10.2CD40LG, CD79A
38atheroembolism of kidney10.2CD40LG, CD79A
39partial sensory epilepsy10.2CD40LG, CD79A
40ritscher-schinzel syndrome 110.2CD40LG, CD79A
41diabetic angiopathy10.2CD40LG, CD79A
42muscular dystrophy10.2CD40LG, CD79A
43dumping syndrome10.2CD40LG, CD79A
44striatonigral degeneration10.2CD40LG, CD79A
45ciliary body spindle cell melanoma10.2CD40LG, CD79A
46purulent endophthalmitis10.2CD40LG, CD79A
47mu chain disease10.2CD40LG, CD79A
48generalized atherosclerosis10.2CD40LG, CD79A
49bursitis10.2CD40LG, CD79A
50syphilis10.2CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms & Phenotypes for Cryoglobulinemia

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MGI Mouse Phenotypes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.8CD27, CD40LG, CD5, CD79A, CD81, CR2
2MP:00053876.0CD27, CD40LG, CD5, CD79A, CD81, CR2

Drugs & Therapeutics for Cryoglobulinemia

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Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 4, Phase 2, Phase 31692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Antirheumatic AgentsPhase 4, Phase 2, Phase 310956
3
SofosbuvirapprovedPhase 2, Phase 32591190307-88-045375808
Synonyms:
 
S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate
SOVALDI
4
LedipasvirapprovedPhase 2, Phase 31071256388-51-867505836
Synonyms:
 
methyl [(2S)-1-{(6S)-6-[4-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate
5Antiviral AgentsPhase 2, Phase 3, Phase 19967
6Anti-Infective AgentsPhase 2, Phase 3, Phase 122062
7Ledipasvir, sofosbuvir drug combinationPhase 2, Phase 356
8
AldesleukinapprovedPhase 1, Phase 240585898-30-2, 110942-02-4
Synonyms:
125-L-serine-2-133-interleukin 2 (human reduced)
 
Interleukin-2 aldesleukin
Interleukin-2(2-133),125-ser
Recombinant interleukin-2 human
9
Prednisoneapproved, vet_approvedPhase 2139853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
10
s 1 (combination)Phase 1, Phase 2378
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
11AnalgesicsPhase 1, Phase 211733
12Peripheral Nervous System AgentsPhase 1, Phase 223689
13Interleukin-2Phase 1, Phase 2571
14Analgesics, Non-NarcoticPhase 1, Phase 26501
15ImmunoglobulinsPhase 26394
16Antibodies, MonoclonalPhase 24039
17Anti-Retroviral AgentsPhase 1, Phase 23296
18AntibodiesPhase 26394
19Anti-HIV AgentsPhase 1, Phase 23162
20
LactitolPhase 1, Phase 2336585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
21HormonesPhase 214415
22Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
23Hormone AntagonistsPhase 213180
24glucocorticoidsPhase 25103
25Anti-Inflammatory AgentsPhase 210729
26Antineoplastic Agents, HormonalPhase 25592
27
Ribavirinapproved100336791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
28Liver Extracts4067
29interferons2175

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Study of the Influence of Plasma Exchange on the Pharmacokinetics of RituximabCompletedNCT00820469Phase 4
2Tolerance and Efficacy of Rituximab in Sjogren's DiseaseCompletedNCT00740948Phase 2, Phase 3
3Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related CryoglobulinemiaRecruitingNCT02825212Phase 2, Phase 3
4Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia AreataUnknown statusNCT01840046Phase 1, Phase 2
5Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis PatientsCompletedNCT00574652Phase 1, Phase 2
6Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2
7Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia VasculitisRecruitingNCT02556866Phase 2
8Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingUnknown statusNCT01932021
9Characterization of Clonal B Cell Populations in HCV InfectionCompletedNCT00435201
10The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune DisordersCompletedNCT00960713
11Hepatitis C Virus and the Humoral Immune SystemCompletedNCT00219999
12Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
13Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia VasculitisRecruitingNCT02856243
14Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based TreatmentRecruitingNCT03042520
15Clinical Transcriptomics in Systemic Vasculitis (CUTIS)RecruitingNCT03004326
16Vasculitis Pregnancy RegistryRecruitingNCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

36
B cells, Skin, Liver, Kidney, Thyroid, Bone, Brain

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. (27666584)
2017
2
How I treat cryoglobulinemia. (27799164)
2017
3
Micro and nanoparticles as possible pathogenetic co-factors in mixed cryoglobulinemia. (27694373)
2017
4
MACULAR PERIVENOUS RETINAL WHITENING AND PRESUMED RETINO-CILIARY SPARING IN A RECURRENT CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH THE ANTIPHOSPHOLIPID SYNDROME AND CRYOGLOBULINEMIA. (27902540)
2016
5
A systemic lupus erythematosus patient presenting as type B insulin resistance complicated with cryoglobulinemia. (27416845)
2016
6
Incidence of thyroid disorders in mixed cryoglobulinemia: Results from a longitudinal follow-up. (26970485)
2016
7
Digital ischemic necrosis with cryoglobulinemia associated with hepatitis B infection. (27857479)
2016
8
Hepatic and Mesenteric Vasculitis as Presenting Manifestation of Mixed Cryoglobulinemia Related to Chronic Hepatitis C Virus Infection in a Female Patient. (27219310)
2016
9
Successful ledipasvira88+a88sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. (27848256)
2016
10
Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study. (27161362)
2016
11
Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study. (26853322)
2016
12
Clinical and Morphologic Spectrum of Renal Involvement in Patients with HBV-Associated Cryoglobulinemia. (27062412)
2016
13
Coronary artery bypass grafting in a patient with active idiopathic cryoglobulinemia: revisiting the issue. (26908383)
2016
14
Cryoglobulinemia in a patient with chronic lymphocytic leukemia - A case report and review of literature of renal involvement in CLL. (27519936)
2016
15
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. (27672862)
2016
16
Successful Treatment of Pyoderma Gangrenosum with Cryoglobulinemia and Hepatitis C. (27345376)
2016
17
Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia. (27483451)
2016
18
HCV-associated cryoglobulinemia vasculitis: are its days numbered? (27797754)
2016
19
Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia. (27139837)
2016
20
An Unusual Case of HCV Negative Cryoglobulinemia Presenting as Symmetrical Peripheral Gangrene. (27190872)
2016
21
A Rare Cause of Unilateral Central Retinal Vein Occlusion in a Young Patient: Type III Mixed Cryoglobulinemia. (27418988)
2016
22
Purtscher-like Retinopathy as a Rare Presentation of Cryoglobulinemia. (27162457)
2016
23
The possible persistence of mixed cryoglobulinemia stigmata in spite of viral eradication: Insufficient or too late antiviral treatment? (27943334)
2016
24
Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia. (27403724)
2016
25
Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. (26785421)
2016
26
Unique Renal Manifestation of Type I Cryoglobulinemia, With Massive Crystalloid Deposits in Glomerular Histiocytes, Podocytes, and Endothelial Cells. (26796493)
2016
27
The correlation between antiphospholipid syndrome and cryoglobulinemia: case series of 4 patients and review of the literature. (27267327)
2016
28
Refractory Mononeuritis Multiplex Due to Hepatitis C Infection and Cryoglobulinemia: Efficient Response to Rituximab. (27119277)
2016
29
Virologic, Clinical, and Immune Response Outcomes of Patients With Hepatitis C Virus-Associated Cryoglobulinemia Treated With Direct-Acting Antivirals. (27725289)
2016
30
Mixed cryoglobulinemia-associated SjAPgren's syndrome leading to spontaneous rupture of the kidney: a case report. (27042145)
2016
31
Annular leukocytoclastic vasculitis associated with essential mixed cryoglobulinemia. (27098553)
2016
32
Cold-associated painful purple digits due to type I cryoglobulinemia. (27681488)
2016
33
Lymphoproliferative associated type 1 cryoglobulinemia. (26271811)
2015
34
Cryoglobulinemia presenting with crystals in peripheral blood. (26966746)
2015
35
Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment. (26060059)
2015
36
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)
2015
37
Successful treatment of HCV-associated cryoglobulinemia with ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin: A case report. (26414149)
2015
38
Glomerulonephritis and cryoglobulinemia: first manifestation of visceral leishmaniasis. (25600859)
2015
39
Recurrent Mixed Cryoglobulinemia (MCS): A Case Report and Literature Review. (26422544)
2015
40
Early onset mixed cryoglobulinemia in hepatitis C. (26275272)
2015
41
Cryoglobulinemia in a Tunisian internal medicine department. (26039888)
2015
42
Abnormal CD4a88+a88T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection. (26129991)
2015
43
Cryofibrinogenemia: a marker of severity of cryoglobulinemia vasculitis. (25827358)
2015
44
Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review. (26031898)
2015
45
Cryoglobulinemia Vasculitis. (25837517)
2015
46
1259: CRYOGLOBULINEMIA DUE TO HEPATITIS C LEADING TO LIFE-THREATENING PULMONARY ALVEOLAR HEMORRHAGE. (26570920)
2015
47
Cryoglobulinemia precipitated by targeted temperature management. (25605473)
2015
48
The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. (25452118)
2015
49
Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents. (26474537)
2015
50
Role of CXCL10 in cryoglobulinemia. (25571936)
2015

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.5CD5, CD79A, IFNA2
2
Show member pathways
9.4IFNA2, IFNL3
3
Show member pathways
9.2CD27, CD40LG, TNFSF13B
49.1CD40LG, CR2, TNFSF13B
59.1CD40LG, CD79A, CXCL10, TNFSF13B
6
Show member pathways
9.1IFNA2, IFNL3, TSLP
7
Show member pathways
8.9CD40LG, CXCL11, IFNA2, TNFSF13B
88.9CD40LG, CXCL10, CXCL11, TNFSF13B
98.7CD27, CD40LG, CD5, CR2
10
Show member pathways
7.8CD27, CD40LG, CXCL10, IFNA2, IFNL3, TNFSF13B
11
Show member pathways
7.0CD27, CD40LG, CXCL10, CXCL11, IFNA2, IFNL3

GO Terms for genes affiliated with Cryoglobulinemia

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Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4CD27, CD40LG, CD5, CD79A, CXCL10
2extracellular regionGO:00055767.7CD27, CD40LG, CXCL10, CXCL11, IFNA2, IFNL3
3extracellular spaceGO:00056157.5CD40LG, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin secretionGO:004830510.4CD40LG, TNFSF13B
2positive regulation of cAMP metabolic processGO:003081610.3CXCL10, CXCL11
3positive regulation of cAMP-mediated signalingGO:004395010.3CXCL10, CXCL11
4positive regulation of release of sequestered calcium ion into cytosolGO:005128110.2CXCL10, CXCL11
5T cell chemotaxisGO:001081810.2CXCL10, CXCL11
6defense responseGO:000695210.0CXCL10, CXCL11, IFNA2
7T cell costimulationGO:00312959.9CD40LG, CD5, TNFSF13B
8defense response to virusGO:00516079.7CXCL10, IFNA2, IFNL3
9B cell differentiationGO:00301839.7CD40LG, CD79A, CR2, IFNA2
10B cell proliferationGO:00421009.7CD40LG, CD79A, CR2, IFNA2
11response to lipopolysaccharideGO:00324969.7CD27, CXCL10, CXCL11
12cell surface receptor signaling pathwayGO:00071669.3CD27, CD79A, CD81, CXCL10, IFNA2
13tumor necrosis factor-mediated signaling pathwayGO:00332099.2CD27, CD40LG, TNFSF13B
14inflammatory responseGO:00069549.2CD27, CD40LG, CXCL10, CXCL11, IFNA2
15immune responseGO:00069558.4CD27, CD40LG, CR2, CXCL10, CXCL11, TNFSF13B

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CXCR3 chemokine receptor bindingGO:004824810.3CXCL10, CXCL11
2tumor necrosis factor receptor bindingGO:00051649.8CD40LG, TNFSF13B
3transmembrane signaling receptor activityGO:00048889.0CD27, CD5, CD79A, CR2
4cytokine activityGO:00051258.1CD40LG, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B

Sources for Cryoglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet