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MCID: CRY004
MIFTS: 59

Cryoglobulinemia malady
10 drugs, 58 genes, 18 tissues, 236 related diseases, clinical trials.

Summaries for Cryoglobulinemia

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8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis c and vasculitis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Rheumatoid arthritis and Tuberculosis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds aspartate and ribavirin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:64 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

cryoglobulinemia 8 43 10 45 61
cryoimmunoglobulinaemia 8


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Disease Ontology8 DOID:2917
NCIt40 C26736
SNOMED-CT57 30911005
MeSH35 D003449

Related Diseases for Cryoglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.6IFNA2, IFNA1, TNFSF13B, FAS, HLA-DRB1, CD40LG
2vasculitis31.1ENO1, CD40LG, FN1, IGHM, APOH, TNFSF13B
3hepatitis e31.1CD40LG
4hepatitis d31.0IFNA1, IFNA2
5hepatitis b30.8IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, CXCL10
6membranoproliferative glomerulonephritis30.7TSLP, IFNA2
7cryoglobulinemic vasculitis30.5IFNA2, BCR, TSLP, ENO1, CD40LG, CD5
8arthritis30.4HLA-DRB1, FN1, CXCL10
9macroglobulinemia30.3CD5
10thyroiditis30.3HLA-DRB1, FASLG, IFNA1
11autoimmune hepatitis30.3IFNA1, FAS, HLA-DQB1, HLA-DRB1, CD40LG
12systemic lupus erythematosus30.3CD27, TNFSF13B
13viral hepatitis30.2IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, FN1
14thrombocytopenia30.0IFNA2, IFNA1, APOH, CD40LG
15nephritis30.0CD40LG, FN1, APOH, TNFSF13B
16polyarteritis nodosa29.8IFNA2
17macroglobulinemia, waldenstrom, somatic29.8CD40LG, IGHM
18antiphospholipid syndrome29.8CD40LG, APOH
19uveitis29.8CXCL10, CXCL11, IFNA2
20pemphigus vulgaris29.8HLA-DRB1, TNFSF13B
21b-cell chronic lymphocytic leukemia29.8IGHM, CD5, CD27
22mycosis fungoides29.8IFNA2, IFNA1, CXCL11, CXCL10
23bronchiolitis obliterans29.8CXCL10
24systemic scleroderma29.8TNFSF13B, APOH, HLA-DQB1, HLA-DRB1, CD40LG
25adenocarcinoma29.8FAS, FASLG, CXCL10, MMP7, ENO1
26retinal vasculitis29.8APOH
27hepatitis c virus11.0
28hepatitis a10.8
29hepatitis b virus infection10.4
30autoimmune thyroiditis10.2
31cold agglutinin disease10.2
32rapidly progressive glomerulonephritis10.1
33proliferative glomerulonephritis10.1
34liver lymphoma10.1
35poems syndrome10.1
36lymphoplasmacytic lymphoma10.1
37cryoglobulinemia, familial mixed10.1
38simple cryoglobulinemia10.1
39mononeuritis multiplex10.0
40gastric lymphoma10.0
41churg-strauss syndrome10.0
42cryofibrinogenemia10.0
43mixed cryoglobulinemia type iii10.0
44type ii mixed cryoglobulinemia10.0
45atopic dermatitis10.0TSLP
46acute leukemia10.0BCR
47malaria10.0HLA-DRB1
48measles10.0CD40LG
49hypothyroidism10.0IFNA1
50celiac disease10.0HLA-DQB1

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Clinical Features for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cryoglobulinemia

Drug clinical trials:

Search ClinicalTrials for Cryoglobulinemia

Search NIH Clinical Center for Cryoglobulinemia

Search CenterWatch for Cryoglobulinemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Cryoglobulinemia:

33
Skin, Liver, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Thyroid, Monocytes, Nk cells, T cells, B cells, Endothelial

Animal Models for Cryoglobulinemia or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cryoglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
homeostasis/metabolism phenotype
MP:00053769.9APOH, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
2
cardiovascular system phenotype
MP:00053859.9FASLG, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
3
digestive/alimentary phenotype
MP:00053819.9FAS, FASLG, HLA-DQB1, IGHM, MMP7, TSLP
4
hematopoietic system phenotype
MP:00053979.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
5
cellular phenotype
MP:00053849.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
6
immune system phenotype
MP:00053879.7BCR, TNFSF13B, FAS, FASLG, HLA-DQB1, IGHM
7
mortality/aging
MP:00107689.4APOH, FAS, FASLG, HLA-DQB1, IGHM, FN1

Publications for Cryoglobulinemia

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51PubMed
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Articles related to Cryoglobulinemia:

(show top 50)    (show all 753)
idTitleAuthorsYear
1
Enhanced activation of memory, but not naA^ve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis. (23840845)
2013
2
Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia. (23650540)
2013
3
The spectrum of type I cryoglobulinemia vasculitis: new insights based on 64 cases. (23429354)
2013
4
No evidence of Polyomavirus and EBV infections in Italian patients with mixed cryoglobulinemia infected chronically with HCV. (24374940)
2013
5
Peg-IFNI+/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24. (23606708)
2013
6
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
7
Changes of some humoral immunologic indicators and clinical manifestations of cryoglobulinemia in heroin addicts. (23221138)
2012
8
Peripheral ulcerative keratitis and necrotizing scleritis initiated by trauma in the setting of mixed cryoglobulinemia. (22220165)
2011
9
Interleukin-1I^, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis. (20929277)
2010
10
Rituximab-induced accelerated cryoprecipitation in hepatitis C virus-associated mixed cryoglobulinemia has parallels with intravenous immunoglobulin-induced immune complex deposition in mixed cryoglobulinemia: comment on the article by SA"ne et al. (20662059)
2010
11
Management of hepatitis C virus-related mixed cryoglobulinemia. (20399313)
2010
12
A case of essential mixed cryoglobulinemia and associated acquired von-Willebrand disease treated with rituximab. (18193394)
2009
13
Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemia. (19950277)
2009
14
Persisting mixed cryoglobulinemia in Chikungunya infection. (19190731)
2009
15
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
16
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
17
Response to bortezomib in refractory type I cryoglobulinemia. (18756542)
2008
18
Efficacy and risk of rituximab in type II mixed cryoglobulinemia: a significant case report. (17936216)
2007
19
Treatment of type II cryoglobulinemia associated with hepatitis C with rituximab. (16721231)
2006
20
Natural history and therapy of 66 patients with mixed cryoglobulinemia. (16755564)
2006
21
Hepatitis C virus-related cryoglobulinemia and glomerulonephritis: pathogenesis and therapeutic strategies. (16052839)
2005
22
Treatment with peg-interferon alfa-2b and ribavirin of hepatitis C virus-associated mixed cryoglobulinemia: a pilot study. (15826710)
2005
23
Gastrointestinal bleeding, cryoglobulinemia, and hepatitis C. (15128376)
2004
24
Immunoadsorption apheresis (Selesorb) in the treatment of chronic hepatitis C virus-related type 2 mixed cryoglobulinemia. (12725944)
2003
25
Severe cutaneous vasculitis following intravenous infusion of gammaglobulin in a patient with type II mixed cryoglobulinemia. (12051404)
2002
26
Myths, misconceptions and mixed cryoglobulinemia associated with HCV infection. (16491057)
2002
27
Glomerulonephritis with microtubular deposits associated with cryoglobulinemia and chronic active hepatitis. (12167108)
2002
28
Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia. (10925464)
2000
29
Close association between HCV infection and cryoglobulinemia in patients on chronic hemodialysis. (10364716)
1999
30
Rituximab for the treatment of type II mixed cryoglobulinemia. (10586221)
1999
31
Cryoglobulinemia after intravesical administration of Bacille Calmette-GuAcrin. (9502479)
1998
32
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
33
Hepatitis C virus infection and type II cryoglobulinemia: an immunological perspective. (9397973)
1997
34
Cerebral ischemia in patients with hepatitis C virus infection and mixed cryoglobulinemia. (8656709)
1996
35
Hepatitis C virus in mixed cryoglobulinemia and B cell lymphoma. (8162649)
1994
36
Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. (7949176)
1994
37
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
38
Association between hepatitis C virus and mixed cryoglobulinemia. (1656512)
1991
39
Peripheral and central nervous system involvement in essential mixed cryoglobulinemia: a case report. (1884525)
1991
40
Recurrent essential mixed cryoglobulinemia in renal allografts. Report of two cases and review of the literature. (2525879)
1989
41
Renal involvement in essential mixed cryoglobulinemia: a peculiar type of immune-mediated renal disease. (2963505)
1988
42
Abnormalities in dermal vessel walls of normal skin of patients with essential mixed cryoglobulinemia. An ultrastructural study. (3787095)
1986
43
Accelerated periodontal disease in a patient with essential mixed cryoglobulinemia. (6579460)
1983
44
Immunoglobulin M-Immunoglobulin G mixed cryoglobulinemia in Schistosoma japonicum-infected rabbits. (6404826)
1983
45
Prolonged plasma exchange in the treatment of renal involvement in essential mixed cryoglobulinemia. (6642737)
1983
46
Complement activation and impaired capacity to solubilize immune complexes or to prevent their formation in essential mixed cryoglobulinemia. (6333960)
1983
47
The effect of combination therapy (steroids, immunosuppressives, and plasmapheresis) on 5 mixed cryoglobulinemia patients with renal, neurologic, and vascular involvement. (6272817)
1981
48
The complement system in essential mixed cryoglobulinemia. (7466165)
1980
49
Concomitant cryoglobulinemia and cold agglutinin disease. Clinical, immunochemical, and post-mortem investigations. (417968)
1978
50
Immune complexes and mixed cryoglobulinemia. (5458000)
1970

Genetic Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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30KEGG, 54Reactome, 12EMD Millipore, 53R&D Systems, 56SinoBiological, 38NCBI BioSystems Database, 52QIAGEN
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Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Rheumatoid arthritis30
10.4TNFSF13B
2
Tuberculosis30
10.3HLA-DQB1, HLA-DRB1
3
FasL/ CD95L signaling54
10.3FAS, FASLG
4
Regulation by c-FLIP54
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10.3FASLG, FAS
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.2IFNA2, FN1, IFNA1
6
Apoptosis and survival Apoptotic TNF-family pathways
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10.2FASLG, FAS, CD27
7
Cytosolic DNA-sensing pathway30
10.2IFNA1, CXCL10, IFNA2
8
Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response12
10.2FN1, CXCL11, CXCL10
9
Interferon Signaling54
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10.2HLA-DRB1, HLA-DQB1, IFNA1, IFNA2
10
Immune response Fc epsilon RI pathway12
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10.1FASLG, IGHM, IFNA1, IFNA2, FAS
11
Immune System54
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10.1CD40LG, IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, IGHM
12
TNF Signaling56
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10.0TNFSF13B, FAS, FASLG, HLA-DQB1, CD40LG, CD27
13
Toll-like receptor signaling pathway38
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10.0IFNA2, IFNA1, FAS, FASLG, CXCL11, CXCL10
14
Influenza A30
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9.9IFNA2, IFNA1, FAS, FASLG, HLA-DQB1, HLA-DRB1
15
Allograft rejection30
Hide members
9.9HLA-DRB1, TNFSF13B, FAS, FASLG, HLA-DQB1, CD40LG
16
PEDF Induced Signaling52
Hide members
9.8FAS, IFNA1, TNFSF13B, FASLG, CD27, CXCL11

Compounds for genes affiliated with Cryoglobulinemia

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45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1aspartate4510.8CD40LG, FASLG
2ribavirin45 50 1112.8CD40LG, IFNA2
3ivig4510.7APOH, CD40LG
4hydroxychloroquine45 1111.7IFNA2, CD40LG, APOH
5infliximab45 50 1112.7CXCL10, APOH, IFNA2
6gliadin4510.7CD40LG
7blys4510.6TNFSF13B, BCR, CD40LG
8atpo45 2911.6IFNA1, FAS, FASLG, APOH
9serine4510.6BCR, FN1
102-chlorodeoxyadenosine4510.6CD40LG, FASLG, FAS, IFNA1
11dextran sulfate4510.6CD40LG, APOH, MMP7, FN1
12fludarabine45 1111.6FAS, CD40LG, FASLG, IFNA1
13indomethacin45 60 29 1113.6FN1
14agar4510.6FASLG, FN1, FAS
15busulfan45 1111.6IFNA2, IFNA1, BCR
16allergens4510.6TSLP, CXCL10, HLA-DRB1, CD40LG
17neopterin4510.5IFNA1, CD40LG, CXCL10, IFNA2
18cytarabine45 50 1112.5IFNA2, IFNA1, FAS, FASLG, BCR
19cyclophosphamide45 50 1112.5BCR, FASLG, APOH, IFNA2, IFNA1
20ifn-alpha4510.5IFNA2, IFNA1, FAS, CXCL10, FASLG
21teniposide45 1111.5FAS, IFNA1, FASLG
22rantes4510.5FASLG, FAS, CXCL11, CD40LG, IFNA1
23cyclosporin a45 29 6012.5CD40LG, CXCL11, FN1, IFNA1
24thalidomide45 50 60 1113.5CD40LG, IFNA2, FASLG, IFNA1
25creatinine4510.5APOH, CXCL10, ENO1, TNFSF13B, FAS
26rituximab45 50 1112.4BCR, CD40LG, FASLG, APOH, TNFSF13B, IFNA1
27paraffin4510.4FN1, FAS, FASLG, CD5, CD40LG, MMP7
28genistein45 29 60 2 11 2415.4FN1, CXCL10, FAS, FASLG, BCR, CD40LG
29polyethylene glycol4510.4IFNA1, IFNA2, CD40LG, FN1
30pegasys4510.4IFNA2, IFNA1
31doxorubicin45 50 1112.4MMP7, FN1, FAS, IFNA1, IFNA2, CD40LG
32lactate4510.4APOH, FAS, FASLG, FN1, ENO1, CD40LG
33imiquimod45 29 60 1113.4FASLG, IFNA1, IFNA2
34dexamethasone45 50 29 1113.4CD40LG, CXCL11, FN1, FASLG, IFNA1, FAS
35cisplatin45 50 60 1113.3FASLG, FN1, FAS, CD40LG, IFNA1, IFNA2
36thymidine45 2411.3CXCL10, FN1, FASLG, FAS, IFNA1, IFNA2
37phosphatidylinositol4510.3FAS, BCR, APOH, FASLG, TSLP, MMP7
38oligonucleotide4510.3BCR, MMP7, CXCL11, FASLG, HLA-DRB1, HLA-DQB1
39alanine4510.3CXCL10, IFNA2, CD40LG, FN1, HLA-DRB1, FASLG
40heparin45 29 11 2413.3FASLG, CD40LG, BCR, FAS, APOH, FN1
41cysteine4510.3FASLG, FAS, IFNA2, CD40LG, MMP7, CD27
42vegf4510.2CXCL10, MMP7, IFNA1, CD40LG, FN1, FASLG
43retinoic acid45 2411.2IFNA1, IFNA2, FAS, FN1, CD40LG, CXCL10
44arginine4510.2FAS, APOH, ENO1, HLA-DRB1, CD40LG, CXCL11
45thymidylate4510.2IFNA1, IFNA2, FAS, FASLG
46adriamycin4510.2IFNA1, FASLG, FN1, FAS
47tyrosine4510.0TSLP, BCR, FASLG, IFNA1, FAS, HLA-DQB1
48fibrinogen4510.0APOH, FN1, CD40LG, MMP7, ENO1
49prednisolone45 29 1111.9APOH, IFNA1, IFNA2, FAS
50calcium45 50 11 2412.9FASLG, CD5, CD27, CXCL11, BCR, CXCL10

GO Terms for genes affiliated with Cryoglobulinemia

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16Gene Ontology
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Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9FAS, CXCL10, CD27, CD40LG, CD5, HLA-DRB1
2extracellular regionGO:0055769.8CXCL10, CXCL11, CD27, FN1, IGHM, FASLG
3extracellular spaceGO:0056159.4IFNA2, TNFSF13B, APOH, FASLG, FN1, CD40LG

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FAS, FASLG
2immunoglobulin secretionGO:04830510.6CD40LG, TNFSF13B
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB1, HLA-DQB1
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DQB1, HLA-DRB1
5positive regulation of endothelial cell apoptotic processGO:200035310.5CD40LG, FASLG
6negative regulation of angiogenesisGO:01652510.5FASLG, CXCL10, APOH
7T cell costimulationGO:03129510.4HLA-DRB1, TNFSF13B, HLA-DQB1, CD5
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.3FAS, FASLG
9cell-cell signalingGO:00726710.2IFNA2, FASLG, CXCL10, CXCL11
10positive regulation of leukocyte chemotaxisGO:00269010.2CXCL10, CXCL11
11immune responseGO:00695510.2CXCL11, HLA-DQB1, HLA-DRB1, IGHM, TNFSF13B, CXCL10
12inflammatory responseGO:00695410.2CD40LG, CXCL11, CXCL10, IFNA2
13signal transductionGO:0071659.7CXCL11, BCR, CXCL10, FASLG, FAS, TNFSF13B

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.3HLA-DRB1, HLA-DQB1
2tumor necrosis factor receptor bindingGO:00516410.2TNFSF13B, FASLG, CD40LG
3cytokine activityGO:00512510.1TSLP, CD40LG, FASLG, TNFSF13B, IFNA2
4protein bindingGO:0055159.2IFNA2, TNFSF13B, APOH, FAS, FASLG, MT1H

Products for genes affiliated with Cryoglobulinemia

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  • Antibodies
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Sources for Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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