MCID: CRY004
MIFTS: 45

Cryoglobulinemia malady

Rare diseases, Immune diseases categories

Aliases & Classifications for Cryoglobulinemia

About this section

Aliases & Descriptions for Cryoglobulinemia:

Name: Cryoglobulinemia 10 45 47 12 65 36
 
Cryoimmunoglobulinaemia 10


Classifications:



External Ids:

Disease Ontology10 DOID:2917
NCIt42 C26736
SNOMED-CT59 30911005
MeSH36 D003449

Summaries for Cryoglobulinemia

About this section
NIH Rare Diseases:45 Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis and cryoglobulinemia, familial mixed. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Inflammatory Response Pathway and CXCR3-mediated signaling events. The drugs interferon alfa-2b and interferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:10 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:68 Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

About this section

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.4CD27, CD5, CR2
2cryoglobulinemia, familial mixed30.7CD40LG, CD79A, FN1
3multiple myeloma30.6CD40LG, CD79A, FN1
4pemphigus30.3CD40LG, CD79A
5hypersensitivity reaction type iv disease30.2CD40LG, CD79A
6conjunctivitis30.2CD40LG, CD79A
7erythema multiforme30.1CXCL10, CXCL11
8t cell deficiency30.0CD40LG, CD79A, FN1
9systemic lupus erythematosus29.9CD40LG, CD79A, CR2, CXCL10, TNFSF13B
10acute pancreatitis27.6CD27, CD40LG, CD5, CD79A, CD81, CR2
11hepatitis c11.1
12hepatitis c virus11.0
13vasculitis10.8
14type ii mixed cryoglobulinemia10.8
15glomerulonephritis10.7
16membranoproliferative glomerulonephritis10.5
17neuropathy10.5
18hepatitis b10.4
19myeloma10.4
20peripheral neuropathy10.4
21thyroiditis10.4
22b-cell lymphomas10.4
23liver disease10.4
24congenital unilateral hypoplasia of depressor anguli oris10.3CXCL10, CXCL11
25arthritis10.3
26leukemia10.3
27macroglobulinemia10.3
28cryoglobulinemic vasculitis10.3
29rocky mountain spotted fever10.3CD40LG, CXCL10
30acromesomelic dysplasia10.3CD40LG, CXCL10
31olecranon bursitis10.3CD40LG, CD79A
32bilateral hyperactive labyrinth10.3CD40LG, CD79A
33calabro syndrome10.3CD40LG, CD79A
34pulmonary edema10.3CD40LG, CD79A
35ovarian malignant mesothelioma10.3CD40LG, CD79A
36photoallergic dermatitis10.3CD40LG, CD79A
37tuberculous epididymitis10.3CD40LG, CD79A
38mammary paget's disease10.3CD40LG, CD79A
39atopic dermatitis10.3CD40LG, CD79A
40sarcoma10.3CD40LG, CD79A
41bilateral retinoblastoma10.3CD40LG, CD79A
42lichen planus10.3CD40LG, CD79A
43clear cell cystadenofibroma10.3CD40LG, CD79A
44immunotactoid glomerulopathy10.3CD40LG, CD79A
45cocaine dependence10.3CD40LG, CD79A
46hepatic cystic hamartoma10.3CD40LG, CD79A
47autoimmune thyroiditis10.3
48purpura10.3
49traumatic glaucoma10.3CD40LG, CD79A
50early myoclonic encephalopathy10.3CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

About this section

Drugs & Therapeutics for Cryoglobulinemia

About this section

Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 4, Phase 2, Phase 31514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2
AldesleukinapprovedPhase 1, Phase 237285898-30-2
Synonyms:
IL-2
Interleukin-2 precursor
 
Proleukin
T-cell growth factor
TCGF
3
PrednisoneapprovedPhase 2120853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
4
LactitolPhase 1, Phase 2313585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
5Interleukin-2Phase 1, Phase 2472

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of the Influence of Plasma Exchange on the Pharmacokinetics of RituximabCompletedNCT00820469Phase 4
2Tolerance and Efficacy of Rituximab in Sjogren's DiseaseCompletedNCT00740948Phase 2, Phase 3
3Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis PatientsCompletedNCT00574652Phase 1, Phase 2
4Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2
5Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia VasculitisRecruitingNCT02556866Phase 2
6Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia AreataRecruitingNCT01840046Phase 1, Phase 2
7The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune DisordersCompletedNCT00960713
8Hepatitis C Virus and the Humoral Immune SystemCompletedNCT00219999
9Characterization of Clonal B Cell Populations in HCV InfectionCompletedNCT00435201
10Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingRecruitingNCT01932021

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Cryoglobulinemia

Genetic Tests for Cryoglobulinemia

About this section

Anatomical Context for Cryoglobulinemia

About this section

MalaCards organs/tissues related to Cryoglobulinemia:

33
B cells, Skin, Liver, Kidney, Bone, Thyroid, Brain

Animal Models for Cryoglobulinemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Cryoglobulinemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.3CD27, CD40LG, CD5, CD79A, CD81, CR2
2MP:00053876.0CD27, CD40LG, CD5, CD79A, CD81, CR2

Publications for Cryoglobulinemia

About this section

Articles related to Cryoglobulinemia:

(show top 50)    (show all 799)
idTitleAuthorsYear
1
Pulmonary hemorrhage in cryoglobulinemia. (25493699)
2015
2
Influence of HCV and HIV on Development of Cryoglobulinemia. (25723551)
2015
3
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)
2015
4
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
5
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
6
The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)
2011
7
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
8
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
9
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
10
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
11
Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)
2009
12
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
13
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
14
Cryoglobulinemia and renal disease. (18408474)
2008
15
High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)
2008
16
Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)
2008
17
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)
2008
18
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
19
Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)
2007
20
Cryoglobulinemia. (17289231)
2007
21
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
22
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
23
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
24
Images in clinical medicine. Mixed cryoglobulinemia. (15972869)
2005
25
Autoamputation in a patient with cryoglobulinemia. (15468383)
2004
26
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
27
HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)
2003
28
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
29
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
30
Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)
2000
31
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
32
Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)
1999
33
Cryoglobulinemia. (10626153)
1999
34
Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)
1999
35
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
36
Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)
1995
37
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
38
Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)
1994
39
The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)
1994
40
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
41
The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)
1991
42
Cryoglobulinemia type II]. (2074925)
1990
43
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
44
Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)
1986
45
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
46
Synovial fluid in mixed cryoglobulinemia. (737009)
1978
47
Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)
1978
48
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
49
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Cryoglobulinemia

About this section

Expression for genes affiliated with Cryoglobulinemia

About this section
Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

About this section

GO Terms for genes affiliated with Cryoglobulinemia

About this section

Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CD27, CD40LG, CD5, CD79A, CR2, CXCL10
2extracellular spaceGO:00056157.5CD40LG, CXCL10, CXCL11, FN1, IFNA2, TNFSF13B
3extracellular regionGO:00055767.2CD27, CXCL10, CXCL11, FN1, IFNA2, TNFSF13B

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin secretionGO:004830510.3CD40LG, TNFSF13B
2B cell activationGO:004211310.1CD79A, CR2
3positive regulation of cAMP metabolic processGO:00308169.8CXCL10, CXCL11
4positive regulation of cAMP-mediated signalingGO:00439509.8CXCL10, CXCL11
5positive regulation of release of sequestered calcium ion into cytosolGO:00512819.8CXCL10, CXCL11
6tumor necrosis factor-mediated signaling pathwayGO:00332099.7CD27, CD40LG, TNFSF13B
7T cell chemotaxisGO:00108189.7CXCL10, CXCL11
8positive regulation of leukocyte chemotaxisGO:00026909.7CXCL10, CXCL11
9B cell differentiationGO:00301839.5CD40LG, CD79A, CR2, IFNA2
10B cell proliferationGO:00421009.5CD40LG, CD79A, CR2, IFNA2
11regulation of immune responseGO:00507769.4CD40LG, CD81, TNFSF13B
12response to lipopolysaccharideGO:00324969.1CD27, CXCL10, CXCL11
13cell surface receptor signaling pathwayGO:00071668.8CD27, CD79A, CD81, CXCL10, IFNA2
14positive regulation of cell proliferationGO:00082848.7CD81, CXCL10, FN1, TNFSF13B
15inflammatory responseGO:00069548.4CD27, CD40LG, CXCL10, CXCL11, IFNA2
16immune responseGO:00069557.5CD27, CD40LG, CR2, CXCL10, CXCL11, TNFSF13B

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:000516410.1CD40LG, TNFSF13B
2CXCR3 chemokine receptor bindingGO:00482489.2CXCL10, CXCL11
3cytokine activityGO:00051258.8CD40LG, IFNA2, TNFSF13B, TSLP
4transmembrane signaling receptor activityGO:00048888.8CD27, CD5, CD79A, CR2
5heparin bindingGO:00082018.8CXCL10, CXCL11, FN1

Sources for Cryoglobulinemia

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet