Cryoglobulinemia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

NIH Rare Diseases:⁴⁵ Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to purpura and proliferative glomerulonephritis, and has symptoms including vasculitic rashand cryoglobulinemic purpura. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Inflammatory Response Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:¹⁰ A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:⁶⁸ Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)

id	Related Disease	Score	Top Affiliating Genes
1	purpura	30.9	CD40LG, CD79A
2	proliferative glomerulonephritis	30.7	CD40LG, CD79A
3	pemphigus	30.2	CD40LG, CD79A
4	blue toe syndrome	30.0	CD40LG, CD79A
5	complex regional pain syndrome	29.4	CD27, IFNA2
6	viral hepatitis	29.4	CD81, CXCL10, IFNA2
7	pneumocystosis	29.4	CD27, CD40LG, CD79A
8	systemic lupus erythematosus	28.8	CD40LG, CD79A, CR2, CXCL10, TNFSF13B
9	familial mixed cryoglobulinemia	12.1
10	type ii mixed cryoglobulinemia	12.0
11	mixed cryoglobulinemia type iii	12.0
12	simple cryoglobulinemia	11.9
13	cryoglobulinemic vasculitis	11.7
14	hepatitis c virus	11.1
15	rare endometriosis	10.8	CXCL10, CXCL11
16	hepatitis	10.8
17	hepatitis c	10.8
18	rickettsia parkeri spotted fever	10.7	CD40LG, CXCL10
19	typhus	10.6	CD40LG, CD79A
20	pulmonary edema	10.6	CD40LG, CD79A
21	congenital hypogammaglobulinemia	10.6	CD40LG, CD79A
22	calabro syndrome	10.6	CD40LG, CD79A
23	gamma heavy chain disease	10.6	CD40LG, CD79A
24	exanthema subitum	10.6	CD40LG, CD79A
25	osteomalacia	10.6	CD40LG, CD79A
26	epidermolysis bullosa simplex	10.6	CD40LG, CD79A
27	acute salpingitis	10.6	CD40LG, CD79A
28	beriberi	10.6	CD40LG, CD79A
29	cystitis	10.6	CD40LG, CD79A
30	choroid plexus meningioma	10.6	CD40LG, CD79A
31	immunotactoid glomerulopathy	10.6	CD40LG, CD79A
32	subacute delirium	10.6	CD40LG, CD79A
33	chronic hiccups	10.6	CD79A, TNFSF13B
34	alpha chain disease	10.6	CD40LG, CD79A
35	dysgammaglobulinemia	10.6	CD40LG, CD79A
36	generalized atherosclerosis	10.6	CD40LG, CD79A
37	central sleep apnea	10.6	CD40LG, CD79A
38	sialadenitis	10.6	CD40LG, CD79A
39	ureteral lymphoma	10.6	CD40LG, CD79A
40	mixed lacrimal gland cancer	10.6	CD40LG, CD79A
41	somatoform disorder	10.6	CD40LG, CD79A
42	duodenal benign neoplasm	10.6	CD79A, CXCL10
43	aids phobia	10.6	CD40LG, CD79A
44	ocular hypotension	10.6	CD40LG, CD79A
45	tenosynovitis	10.6	CD40LG, CD79A
46	hyperostosis	10.6	CD40LG, IFNA2
47	brucella melitensis brucellosis	10.6	CD40LG, CD79A
48	fallopian tube carcinoma	10.6	CD40LG, CD79A
49	maxillary sinusitis	10.6	CD40LG, CD79A
50	plasma protein metabolism disease	10.6	CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:

Symptoms for Cryoglobulinemia

Sources:
⁶⁵UMLS
See all MalaCards sources

UMLS symptoms related to Cryoglobulinemia:

vasculitic rash, cryoglobulinemic purpura

Drugs & Therapeutics for Cryoglobulinemia

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library, ⁶⁵UMLS, ⁴³NDF-RT, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

rituximab

approved

Phase 4, Phase 2, Phase 3

1582

174722-31-7

10201696

Synonyms:

AntiCD20

IDEC-102

IDEC-C2B8

Ig gamma-1 chain C region

MabThera

Mabthera

Rituxan

rituximab

2

Antirheumatic Agents

Phase 4, Phase 2, Phase 3

8496

3

Immunologic Factors

Phase 4, Phase 2, Phase 3

18483

4

Aldesleukin

approved

Phase 1, Phase 2

387

85898-30-2

Synonyms:

IL-2

Interleukin-2 precursor

Proleukin

T-cell growth factor

TCGF

5

Prednisone

approved

Phase 2

1267

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

ACon0_000082

ACon1_000297

AI3-52939

Adasone

Ancortone

Apo-Prednisone

Apo-prednisone

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

Betapar

Bicortone

Bio-0649

C07370

C21H26O5

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

CPD001227202

Cartancyl

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

DB00635

Dacorten

Dacortin

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

Delta Cortelan

Delta E

Delta E.

Delta-Cortelan

Delta-Dome

Delta-cortelan

Delta-cortisone

Delta-cortone

Delta-dome

Deltacortene

Deltacortisone

Deltacortone

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Di-Adreson

Diadreson

EINECS 200-160-3

Econosone

Encorton

Encortone

Enkortolon

Enkorton

Fernisone

Fiasone

HMS1568O15

HMS2090J13

HSDB 3168

Hostacortin

In-Sone

Incocortyl

Juvason

Kortancyl

LMST02030180

LS-1325

Liquid Pred

Lisacort

Lodotra

MEGxm0_000443

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

Me-Korti

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI-C04897

NCI60_000008

NSC 10023

NSC10023

Nisona

Nizon

Novoprednisone

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

PRD

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Perrigo Prednisone

Precort

Predeltin

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Prednison

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone Intensol

Prednisone [INN:BAN]

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Prestwick_405

Pronison

Pronisone

Rayos

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

SK-Prednisone

SMR000718760

SMR001227202

SPBio_002214

Servisone

Sone

Sterapred

Supercortil

U 6020

UNII-VB0R961HZT

Ultracorten

Ultracortene

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Winpred

Wojtab

ZINC03875357

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

delta cortelan

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

delta-Cortisone

delta-Cortone

6

Immunoglobulins

Phase 2

4477

7

Antibodies, Monoclonal

Phase 2

2413

8

Antibodies

Phase 2

4477

9

Lactitol

Phase 1, Phase 2

320

585-86-4

3871

Synonyms:

4-O-b-D-Galactopyranosyl-D-glucitol, 9CI

E966

Emportal

Floralac

Importal

Oponaf

Portolac

10

Analgesics

Phase 1, Phase 2

9358

11

Analgesics, Non-Narcotic

Phase 1, Phase 2

5184

12

Interleukin-2

Phase 1, Phase 2

487

13

s 1 (combination)

Phase 1, Phase 2

325

Synonyms:

Gimeracil / oteracil / tegafur

TS 1

14

Peripheral Nervous System Agents

Phase 1, Phase 2

18510

15

glucocorticoids

Phase 2

3896

16

Anti-Inflammatory Agents

Phase 2

8478

17

Antineoplastic Agents, Hormonal

Phase 2

4256

18

Hormone Antagonists

Phase 2

10002

19

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2

9988

20

Hormones

Phase 2

11748

21

Liver Extracts

3572

Interventional clinical trials:

(show all 12)

id	Name	Status	NCT ID	Phase
1	Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab	Completed	NCT00820469	Phase 4
2	Tolerance and Efficacy of Rituximab in Sjogren's Disease	Completed	NCT00740948	Phase 2, Phase 3
3	Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients	Completed	NCT00574652	Phase 1, Phase 2
4	Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic Vasculitis	Completed	NCT00029107	Phase 2
5	Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis	Recruiting	NCT02556866	Phase 2
6	Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata	Recruiting	NCT01840046	Phase 1, Phase 2
7	The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders	Completed	NCT00960713
8	Hepatitis C Virus and the Humoral Immune System	Completed	NCT00219999
9	Characterization of Clonal B Cell Populations in HCV Infection	Completed	NCT00435201
10	Impact of Vasculitis on Employment and Income	Completed	NCT02476292
11	Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting	Recruiting	NCT01932021
12	Vasculitis Pregnancy Registry	Recruiting	NCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS⁶⁵/NDF-RT⁴³:

interferon alfa-2a

interferon alfa-2b

interferon alfa-3n,human leukocyte derived

interferon alfacon-1

interferon gamma-1b

interferons

peginterferon alfa-2a

peginterferon alfa-2b

recombinant interferon beta-1a

recombinant interferon beta-1b

Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

Anatomical Context for Cryoglobulinemia

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Cryoglobulinemia:

³³

B cells, Skin, Liver, Breast, Kidney, Bone, Thyroid

Animal Models for Cryoglobulinemia or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Cryoglobulinemia:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	6.3	CD27, CD40LG, CD5, CD79A, CD81, CR2
2	immune system	MP:0005387	6.0	CD27, CD40LG, CD5, CD79A, CD81, CR2

Publications for Cryoglobulinemia

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Cryoglobulinemia:

(show top 50) (show all 823)

id	Title	Authors	Year
1	Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. (26785421)	de Lorenzo-Pinto A.... Pinilla Llorente B.	2016
2	Pulmonary hemorrhage in cryoglobulinemia. (25493699)	Kirkpatrick G.... van Eeden S.	2015
3	Influence of HCV and HIV on Development of Cryoglobulinemia. (25723551)	Rogalska-PA8oA8ska M.... Flisiak R.	2015
4	Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)	Ayad M.W.... Sakr A.S.	2015
5	Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)	Visentini M.... Fiorilli M.	2012
6	Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)	Wallace E.... Schulman G.	2012
7	A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)	Almog O.... Levy Y.	2010
8	Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)	Giovanardi P.... Bondi M.	2010
9	Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)	De Vita S.... Quartuccio L.	2010
10	Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)	Fukunaga N.... Okada Y.	2010
11	Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)	Annear N.M.... Salama A.D.	2010
12	Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)	De Re V.... Toffoli G.	2009
13	Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)	Guo S.... Alpers C.E.	2009
14	Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)	Alatoom A.... Wang H.Y.	2009
15	Cryoglobulinemia and renal disease. (18408474)	Alpers C.E.... Smith K.D.	2008
16	High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)	Antonelli A.... Ferrannini E.	2008
17	Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)	Satish S.... Unni V.N.	2008
18	Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)	Saadoun D.... Cacoub P.	2008
19	Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)	Mazzaro C.... Tirelli U.	2007
20	Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)	Alpa M.... Roccatello D.	2007
21	Cryoglobulinemia. (17289231)	Tedeschi A.... Morra E.	2007
22	Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)	Mohan S.... Pogue V.A.	2006
23	Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)	Hermida Lazcano I.... Solera Santos J.	2005
24	Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)	D'Amico E.... Palazzi C.	2005
25	Images in clinical medicine. Mixed cryoglobulinemia. (15972869)	Josephsen G.	2005
26	Autoamputation in a patient with cryoglobulinemia. (15468383)	Overton S.D.... Johnson F.E.	2004
27	Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)	Auzerie V.... Senet P.	2003
28	Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)	Lamprecht P.... Gross W.L.	2000
29	Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)	Kitay-Cohen Y.... Lishner M.	2000
30	Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)	Sanmugarajah J.... Friedman S.	2000
31	Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)	Weinberg J.M.... Kramer E.M.	2000
32	Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)	Cacoub P.... Musset L.	1999
33	Cryoglobulinemia. (10626153)	Dispenzieri A.... Gorevic P.D.	1999
34	Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)	Kerr G.S.... Seeff L.B.	1997
35	Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)	Sepp N.T.... Vogel W.	1995
36	Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)	CuAcllar M.L.... Molina J.F.	1995
37	Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)	Dammacco F.... Rizzi R.	1994
38	The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)	Agnello V.	1994
39	Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)	Disdier P.... Weiller P.J.	1992
40	The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)	Pasquali J.L.... Levallois H.	1991
41	Cryoglobulinemia type II]. (2074925)	Madi N.... Schifferli J.A.	1990
42	POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)	Fishel B.... Yaron M.	1988
43	Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)	Barbieri P.... Bombardieri S.	1986
44	Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)	Chejfec G.... Gould V.E.	1981
45	Synovial fluid in mixed cryoglobulinemia. (737009)	Frayha R.A.	1978
46	Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)	Casali P.... Zanussi C.	1978
47	Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)	Levo Y.... Franklin E.C.	1977
48	Immune complexes and mixed cryoglobulinemia. (5458000)	Barnett E.V.... Cracchiolo A.	1970
49	Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)	ENGLE R.L.	1956
50	(16795070)

Genes related to Cryoglobulinemia

Sources:
²⁰GeneCards, ¹²DISEASES, ⁴⁷Novoseek
See all MalaCards sources

Genes related to Cryoglobulinemia:

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	CD40LG	CD40 Ligand	33.94	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	11875606, 8600660, 2074925 more 16797380, 11769562
2	IFNA2	Interferon, Alpha 2	30.31	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	8955758, 9252075, 8832526
3	CD79A	CD79a Molecule	29.61	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	10380044, 11875606, 1300443
4	TSLP	Thymic Stromal Lymphopoietin	29.00	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	17322382
5	CXCL10	C-X-C Motif Chemokine Ligand 10	24.28	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
6	CD81	CD81 Molecule	23.71	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
7	TNFSF13B	Tumor Necrosis Factor Superfamily Member 13b	23.31	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
8	CD5	CD5 Molecule	23.09	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
9	CD27	CD27 Molecule	23.01	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
10	CR2	Complement Component 3d Receptor 2	22.67	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
11	CXCL11	C-X-C Motif Chemokine Ligand 11	22.62	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
12	FN1	Fibronectin 1	22.37	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)

Variations for Cryoglobulinemia

Expression for genes affiliated with Cryoglobulinemia

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

Sources:
⁵²PathCards, ³⁹NCBI BioSystems Database, ⁵⁶R&D Systems, ³¹KEGG, ⁶²Thomson Reuters, ⁵⁵QIAGEN, ⁵⁷Reactome
See all MalaCards sources

Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Inflammatory Response Pathway³⁹	9.7	CD40LG, FN1
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	9.4	CD5, CD79A, IFNA2
3	IgA-Producing B Cells in the Intestine⁵⁶	9.2	CD40LG, CR2, TNFSF13B
4	B cell receptor signaling pathway (KEGG)³¹ Show member pathways B cell receptor signaling pathway³¹ T cell receptor signaling pathway³¹ TCR Signaling Pathway³⁹ BCR signaling pathway³⁹	8.9	CD40LG, CD79A, CD81, CR2
5	Bacterial infections in CF airways⁶² Show member pathways Immune response TLR signaling pathways⁶² Immune response Bacterial infections in normal airways⁶² IL-1 beta-dependent CFTR expression⁶²	8.8	CXCL10, CXCL11, FN1
6	B Cell Receptor Signaling Pathway (WikiPathways)³⁹ Show member pathways B Cell Receptor Signaling Pathway³⁹	8.7	CD5, CD79A, CD81, CR2
7	B Cell Development Pathways⁵⁶	8.6	CD27, CD40LG, CD5, CR2
8	PEDF Induced Signaling⁵⁵ Show member pathways IL-6 Pathway⁵⁵ Endothelin-1 Signaling Pathway⁵⁵ Cytokine-cytokine receptor interaction³¹ STAT3 Pathway⁵⁵ Glucocorticoid Receptor Signaling⁵⁵ all-trans-Retinoic Acid Signaling in Brain⁵⁵ NFAT Signaling and Lymphocyte Interactions⁵⁵ MIF Regulation of Innate Immune Cells⁵⁵ MIF Mediated Glucocorticoid Regulation⁵⁵ RAR-Gamma-RXR-Alpha Degradation⁵⁵ PGC1Alpha Pathway⁵⁵	7.5	CD27, CD40LG, CXCL10, CXCL11, IFNA2, TNFSF13B
9	Immune System⁵⁷ Show member pathways Innate Immune System⁵⁷ Adaptive Immune System⁵⁷	7.5	CD27, CD40LG, CD79A, CD81, CXCL10, FN1

GO Terms for genes affiliated with Cryoglobulinemia

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	T cell chemotaxis	GO:0010818	9.6	CXCL10, CXCL11
2	positive regulation of cAMP-mediated signaling	GO:0043950	9.5	CXCL10, CXCL11
3	inflammatory response	GO:0006954	9.5	CD27, CXCL10, IFNA2
4	cell-cell signaling	GO:0007267	9.2	CXCL10, CXCL11, IFNA2
5	cell surface receptor signaling pathway	GO:0007166	9.2	CD27, CD81, CXCL10, IFNA2
6	response to lipopolysaccharide	GO:0032496	8.8	CD27, CXCL10, CXCL11
7	immune response	GO:0006955	7.8	CD27, CR2, CXCL10, CXCL11, TNFSF13B