MCID: CRY004
MIFTS: 47

Cryoglobulinemia malady

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Cryoglobulinemia

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Summaries for Cryoglobulinemia

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NIH Rare Diseases:46 Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called "cryoglobulins." at cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. many people affected by this condition will not experience any unusual signs or symptoms. when present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis; joint or muscle pain; purpura; raynaud's phenomenon; skin death; and/or skin ulcers. in some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause. last updated: 5/7/2015

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to psoriasis and mesangial proliferative glomerulonephritis, and has symptoms including cryoglobulinemic purpura and vasculitic rash. An important gene associated with Cryoglobulinemia is CD40LG (CD40 Ligand), and among its related pathways are Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and liver, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:11 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:69 Cryoglobulinemia or cryoglobulinaemia is a medical condition in which the blood contains large amounts... more...

Related Diseases for Cryoglobulinemia

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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 281)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.3CD40LG, CD79A
2mesangial proliferative glomerulonephritis30.2CD40LG, CD79A
3polyarteritis nodosa30.2CD40LG, CD79A
4erythema multiforme29.8CXCL10, CXCL11, IFNL3
5hepatitis b29.4CD27, CD5, CR2
6systemic lupus erythematosus29.1CD40LG, CD79A, CR2, TNFSF13B
7membranoproliferative glomerulonephritis24.7CD27, CD40LG, CD5, CD79A, CD81, CR2
8cryoglobulinemia, familial mixed12.2
9type ii mixed cryoglobulinemia12.0
10mixed cryoglobulinemia type iii12.0
11simple cryoglobulinemia11.9
12hepatitis c virus11.1
13laminopathy type decaudain-vigouroux10.8CXCL10, CXCL11
14hepatitis10.8
15hepatitis c10.8
16cherry allergy10.8CXCL10, CXCL11
17rocky mountain spotted fever10.7CD40LG, CXCL10
18capillary hemangioma10.7CD40LG, CXCL10
19disease_ontology10.7CD40LG, TNFSF13B
20calcific tendinitis10.7CD40LG, CD79A
21medullary sponge kidney10.7CD40LG, CD79A
22variola major10.7CD40LG, CD79A
23mu chain disease10.7CD40LG, CD79A
24calcium metabolism disease10.7CD40LG, CD79A
25retinal cancer10.7CD40LG, CD79A
26focal embolic glomerulonephritis10.7CD40LG, CD79A
27membranous glomerulonephritis10.7CD40LG, CD79A
28heart disease10.7CD40LG, CD79A
29endometrial stromal nodule10.7CD40LG, CD79A
30chronic cystitis10.7CD40LG, CD79A
31van benthem-driessen-hanveld syndrome10.7CD40LG, CD79A
32hemolytic-uremic syndrome10.7CD40LG, CD79A
33partial motor epilepsy10.7CD40LG, CD79A
34benign meningioma10.7CD40LG, CD79A
35parasitic helminthiasis infectious disease10.7CD40LG, CD79A
36occlusion of gallbladder10.7CD40LG, CD79A
37viral meningitis10.7CD40LG, CD79A
38substance-induced psychosis10.7CD40LG, CD79A
39gamma heavy chain disease10.7CD40LG, CD79A
40regional ureteric cancer10.7CD40LG, CD79A
41arteriosclerosis10.7CD40LG, CD79A
42pompholyx10.7CD40LG, CD79A
43bacterial conjunctivitis10.6CD40LG, CD79A
44deep keratitis10.6CD40LG, CD79A
45monoclonal paraproteinemia10.6CD40LG, CD79A
46cockayne syndrome10.6CD40LG, CD79A
47juvenile type testicular granulosa cell tumor10.6CD40LG, CD79A
48testicular brenner tumor10.6CD40LG, CD79A
49oculo cerebro osseous syndrome10.6CD40LG, CD79A
50diabetic angiopathy10.6CD40LG, CD79A

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Symptoms for Cryoglobulinemia

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UMLS symptoms related to Cryoglobulinemia:


cryoglobulinemic purpura, vasculitic rash

Drugs & Therapeutics for Cryoglobulinemia

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Drugs for Cryoglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabPhase 4, Phase 2, Phase 31611174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2
sofosbuvirPhase 2, Phase 32121190307-88-045375808
Synonyms:
 
S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate
SOVALDI
3
ledipasvirPhase 2, Phase 3931256388-51-867505836
Synonyms:
 
methyl [(2S)-1-{(6S)-6-[4-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate
4
lactitolPhase 1, Phase 2325585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
5
AldesleukinPhase 1, Phase 239185898-30-2, 110942-02-4
Synonyms:
125-L-serine-2-133-interleukin 2 (human reduced)
 
Interleukin-2 aldesleukin
Interleukin-2(2-133),125-ser
Recombinant interleukin-2 human
6
s 1 (combination)Phase 1, Phase 2343
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
7INTERLEUKIN-2Phase 1, Phase 2537
8
PrednisonePhase 2131853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
9glucocorticoidsPhase 24756

Interventional clinical trials:

(show all 14)
idNameStatusNCT IDPhase
1Study of the Influence of Plasma Exchange on the Pharmacokinetics of RituximabCompletedNCT00820469Phase 4
2Tolerance and Efficacy of Rituximab in Sjogren's DiseaseCompletedNCT00740948Phase 2, Phase 3
3Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related CryoglobulinemiaRecruitingNCT02825212Phase 2, Phase 3
4Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis PatientsCompletedNCT00574652Phase 1, Phase 2
5Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2
6Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia VasculitisRecruitingNCT02556866Phase 2
7Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia AreataRecruitingNCT01840046Phase 1, Phase 2
8The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune DisordersCompletedNCT00960713
9Hepatitis C Virus and the Humoral Immune SystemCompletedNCT00219999
10Characterization of Clonal B Cell Populations in HCV InfectionCompletedNCT00435201
11Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
12Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia VasculitisRecruitingNCT02856243
13Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingRecruitingNCT01932021
14Vasculitis Pregnancy RegistryRecruitingNCT02593565

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: cryoglobulinemia

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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MalaCards organs/tissues related to Cryoglobulinemia:

34
B cells, Skin, Liver, Kidney, Thyroid, Bone, Brain

Animal Models for Cryoglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Cryoglobulinemia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.5CD27, CD40LG, CD5, CD79A, CD81, CR2
2MP:00053876.4CD27, CD40LG, CD5, CD79A, CD81, CR2

Publications for Cryoglobulinemia

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Articles related to Cryoglobulinemia:

(show top 50)    (show all 828)
idTitleAuthorsYear
1
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. (25800158)
2015
2
Role of CXCL10 in cryoglobulinemia. (25571936)
2015
3
Sudden onset of coma in a 70-year-old woman with cryoglobulinemia. (24516693)
2014
4
Cryoglobulinemia vasculitis: an update. (23196322)
2013
5
Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)
2012
6
The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)
2011
7
A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)
2010
8
Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)
2010
9
Chronic hepatitis C virus infection: prevalence of cryoglobulinemia and renal affection in the Egyptian patients. (21246960)
2010
10
Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)
2009
11
Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)
2009
12
Immunoadsorption apheresis and immunosuppressive drug therapy in the treatment of complicated HCV-related cryoglobulinemia. (19927363)
2009
13
Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemia. (18484642)
2008
14
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
15
Lymphoplasmacytic lymphoma arising in the setting of hepatitis C and mixed cryoglobulinemia. (17878484)
2007
16
Mixed cryoglobulinemia: a model of virus-related disease in internal medicine. (17936230)
2007
17
Lymphoplasmacytic lymphoma associated with polyradiculoneuritis and cryoglobulinemia mimicking polyarteritis nodosa. (17287105)
2007
18
Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)
2006
19
Successful treatment of necrotizing vasculitic lesions after infusion of iloprost in a patient with cryoglobulinemia and chronic HCV infection. (16396716)
2005
20
Cryoglobulinemia. (16304405)
2005
21
Cutaneous vasculitis with undetectable cryoglobulinemia in chronic hepatitis C. (15377307)
2004
22
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
23
HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)
2003
24
Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia. (11877309)
2002
25
Palpable purpura at the site of previous herpes zoster in association with mixed cryoglobulinemia and hepatitis C virus infection. (11436363)
2001
26
Gallbladder vasculitis associated with type-1 cryoglobulinemia. (11281178)
2001
27
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
28
Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)
2000
29
Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)
2000
30
Cryoglobulinemia. (10626153)
1999
31
Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)
1999
32
Hepatitis C virus but not GB virus C/hepatitis G virus has a role in type II cryoglobulinemia. (10513805)
1999
33
Anticardiolipin, anti-beta2-glycoprotein I, and antinucleosome antibodies in hepatitis C virus infection and mixed cryoglobulinemia. Multivirc Group. (9375873)
1997
34
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
35
Monoclonal IgM rheumatoid factor secreted by CD5-negative B cells during mixed cryoglobulinemia. Evidence for somatic mutations and intraclonal diversity of the expressed VH region gene. (7527818)
1995
36
Mixed cryoglobulinemia as a possible preneoplastic disorder. (8849361)
1995
37
Gallbladder vasculitis and mixed cryoglobulinemia. (7835849)
1994
38
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
39
Mixed cryoglobulinemia and hepatitis C virus infection. (1519595)
1992
40
Association between hepatitis C virus and mixed cryoglobulinemia. (1656512)
1991
41
POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)
1988
42
Pseudo-leukocytosis in essential mixed cryoglobulinemia may simulate chronic lymphocytic leukemia. (4053444)
1985
43
Immune complexes and complement profile in essential mixed cryoglobulinemia before and after plasma exchange. (6642740)
1983
44
Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)
1981
45
Hepatitis B virus and essential mixed cryoglobulinemia. (7469231)
1981
46
A newly described control mechanism of complement activation in patients with mixed cryoglobulinemia (cryoglobulins and complement). (7391606)
1980
47
Immune complexes in mixed cryoglobulinemia. (703778)
1978
48
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
49
Immune complexes and mixed cryoglobulinemia. (5458000)
1970
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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Pathways related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5IFNA2, IFNL3
29.3CD5, CD79A, IFNA2
39.3CD40LG, CD79A, CXCL10, TNFSF13B
49.2CD40LG, CR2, TNFSF13B
5
Show member pathways
9.2IFNA2, IFNL3, TSLP
6
Show member pathways
9.0CD40LG, CD79A, CD81, CR2
7
Show member pathways
8.8CD5, CD79A, CD81, CR2
88.7CD40LG, CXCL10, CXCL11, TNFSF13B
98.7CD27, CD40LG, CD5, CR2
10
Show member pathways
6.9CD27, CD40LG, CXCL10, CXCL11, IFNA2, IFNL3

GO Terms for genes affiliated with Cryoglobulinemia

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Cellular components related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0CD27, CD40LG, CD5, CD79A, CXCL10
2extracellular spaceGO:00056157.4CD40LG, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B
3extracellular regionGO:00055767.2CD27, CXCL10, CXCL11, IFNA2, IFNL3, TNFSF13B

Biological processes related to Cryoglobulinemia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin secretionGO:004830510.4CD40LG, TNFSF13B
2tumor necrosis factor-mediated signaling pathwayGO:00332099.8CD27, CD40LG, TNFSF13B
3regulation of immune responseGO:00507769.8CD40LG, CD81, TNFSF13B
4positive regulation of cAMP metabolic processGO:00308169.8CXCL10, CXCL11
5positive regulation of cAMP-mediated signalingGO:00439509.8CXCL10, CXCL11
6T cell chemotaxisGO:00108189.8CXCL10, CXCL11
7T cell costimulationGO:00312959.5CD40LG, CD5, TNFSF13B
8positive regulation of release of sequestered calcium ion into cytosolGO:00512819.4CXCL10, CXCL11
9B cell proliferationGO:00421009.4CD40LG, CD79A, CR2, IFNA2
10defense response to virusGO:00516079.3CXCL10, IFNA2, IFNL3
11B cell differentiationGO:00301839.1CD40LG, CD79A, CR2, IFNA2
12cell surface receptor signaling pathwayGO:00071668.6CD27, CD81, CXCL10, IFNA2
13inflammatory responseGO:00069548.3CD27, CD40LG, CXCL10, CXCL11, IFNA2
14immune responseGO:00069557.9CD27, CR2, CXCL10, CXCL11, TNFSF13B

Molecular functions related to Cryoglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:000516410.2CD40LG, TNFSF13B
2CXCR3 chemokine receptor bindingGO:00482489.4CXCL10, CXCL11
3transmembrane signaling receptor activityGO:00048888.6CD27, CD5, CD79A, CR2
4cytokine activityGO:00051258.4CD40LG, IFNA2, IFNL3, TNFSF13B, TSLP

Sources for Cryoglobulinemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet