Cryoglobulinemia disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Cryoglobulinemia

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ⁶⁴Wikipedia, ³²MalaCards
See all sources

NIH Rare Diseases:⁴² Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards based summary: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis c and glomerulonephritis. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Primary immunodeficiency and Antigen Activates B Cell Receptor Leading to Generation of Second Messengers. The drugs interferon alfa-2a and interferon alfa-2b and the compounds sulfolipid i and sandoglobulin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:⁹ A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:⁶⁴ Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ³⁴MeSH, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Cryoglobulinemia, Aliases & Descriptions:

Name: Cryoglobulinemia ⁹ ⁴² ¹¹ ⁴⁴ ⁶¹

Cryoimmunoglobulinaemia ⁹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases

External Ids:

Disease Ontology⁹ DOID:2917

MeSH³⁴ D003449

SNOMED-CT⁵⁶ 30911005

NCIt³⁹ C26736

UMLS⁶¹ C0010403

Related Diseases for Cryoglobulinemia

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 193)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis c	31.8	CD40LG, IFNA2
2	glomerulonephritis	31.1	CD40LG, CD79A, TSLP
3	purpura	31.1	CD79A
4	membranoproliferative glomerulonephritis	30.9	TSLP, IFNA2, CD79A
5	macroglobulinemia	30.8	CD79A, CD5
6	q fever	30.7	CD79A
7	chronic lymphocytic leukemia	30.6	CD5, IGHM
8	polyarteritis nodosa	30.5	IFNA2
9	hepatitis b	30.5	CD79A, IFNA2, IGHM
10	b-cell lymphomas	30.4	CD5, BCR, IGHM
11	vasculitis	30.4	IGHM, APOH, IFNA2, CD79A, CD40LG
12	viral hepatitis	30.4	IFNA2
13	malt lymphoma	30.3	IGHM, CD5
14	retinal vasculitis	30.2	APOH
15	lupus erythematosus	30.2	APOH, CD79A, CD40LG
16	polyneuropathy	30.2	CD40LG, CD79A, IFNA2
17	hairy cell leukemia	30.2	CD5, IFNA2
18	macroglobulinemia, waldenstrom, somatic	30.1	IGHM, CD40LG
19	myeloma	30.0	IGHM, IFNA2, BCR, CD79A, CD40LG
20	leukemia	30.0	IFNA2, BCR, CD5, CD79A, CD40LG
21	antiphospholipid syndrome	29.7	CD40LG, CD79A, APOH
22	nephritis	29.7	CD40LG, CD79A, APOH
23	cryoglobulinemic vasculitis	29.7	IGHM, TSLP, IFNA2, BCR, CD5, CD40LG
24	thrombocytopenia	29.6	CD40LG, CD79A, IFNA2, APOH
25	systemic lupus erythematosus	29.5	CD40LG, CD79A, BCR, APOH, IGHM
26	rheumatoid arthritis	29.5	IGHM, APOH, CD5, CD79A, CD40LG
27	hepatitis	11.1
28	hepatitis c virus	11.0
29	type ii mixed cryoglobulinemia	10.7
30	neuropathy	10.5
31	dysentery	10.4	CD79A
32	chickenpox	10.4	CD79A
33	agammaglobulinemia 3	10.4	CD79A
34	mumps	10.4	CD79A
35	cryptosporidiosis	10.4	CD79A
36	peripheral neuropathy	10.4
37	hodgkin's lymphoma	10.4
38	multiple myeloma	10.4
39	thyroiditis	10.3
40	liver disease	10.3
41	degos disease	10.3	APOH
42	congenital toxoplasmosis	10.3	CD40LG, CD79A
43	arthritis	10.3
44	immunoglobulin g deficiency	10.3	CD40LG, CD79A
45	selective iga deficiency disease	10.3	CD79A, CD40LG
46	immunodeficiency, centromere instability and facial anomalies syndrome	10.3	CD40LG, CD79A
47	immunoglobulin alpha deficiency	10.3	CD79A, CD40LG
48	immunodeficiency with hyper igm type 1	10.3	CD40LG, CD79A
49	rubella	10.3	CD79A, CD40LG
50	autoimmune thyroiditis	10.3

Graphical network of the top 20 diseases related to Cryoglobulinemia:

Symptoms for Cryoglobulinemia

Drugs & Therapeutics for Cryoglobulinemia

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Cryoglobulinemia

Search NIH Clinical Center for Cryoglobulinemia

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

interferon alfa-2a

interferon alfa-2b

interferon alfa-3n,human leukocyte derived

interferon alfacon-1

interferon gamma-1b

interferons

peginterferon alfa-2a

peginterferon alfa-2b

recombinant interferon beta-1a

recombinant interferon beta-1b

Genetic Tests for Cryoglobulinemia

Anatomical Context for Cryoglobulinemia

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Cryoglobulinemia:

³²

Skin, B cells, Liver, Kidney, Thyroid, Bone, Brain, Bone marrow, T cells, Endothelial, Neutrophil, Lymph node, Lung, Testes, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Monocytes, Nk cells

Animal Models for Cryoglobulinemia or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Cryoglobulinemia:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.5	BCR, CD79A, CD40LG, IGHM
2	hematopoietic system phenotype	MP:0005397	7.7	IGHM, TSLP, BCR, CD5, CD79A, CD40LG
3	immune system phenotype	MP:0005387	7.6	IGHM, TSLP, BCR, CD5, CD79A, CD40LG
4	homeostasis/metabolism phenotype	MP:0005376	7.0	CD79A, BCR, TSLP, APOH, IGHM, CD40LG

Publications for Cryoglobulinemia

Sources:
⁵¹PubMed
See all sources

Articles related to Cryoglobulinemia:

(show top 50) (show all 765)

id	Title	Authors	Year
1	Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. (22678901)	Visentini M.... Fiorilli M.	2012
2	Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)	Wallace E.... Schulman G.	2012
3	The V(H)1-69-expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21(low) phenotype. (21940829)	Visentini M.... Fiorilli M.	2011
4	A dramatic response to intravenous immunoglobulin in a patient with mixed cryoglobulinemia. (20450133)	Almog O.... Levy Y.	2010
5	Splenic infarcts in chronic hepatopathy accompanied by cryoglobulinemia: two case reports. (20190728)	Giovanardi P.... Bondi M.	2010
6	Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)	De Vita S.... Quartuccio L.	2010
7	Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)	Fukunaga N.... Okada Y.	2010
8	Non-hepatitis virus associated mixed essential cryoglobulinemia. (19890273)	Annear N.M.... Salama A.D.	2010
9	Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. (19758144)	De Re V.... Toffoli G.	2009
10	Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis. (19528347)	Guo S.... Alpers C.E.	2009
11	Fatal cerebral hemorrhage in a patient with CD19-positive IgM-producing aggressive plasma cell myeloma, hyperviscosity syndrome and cryoglobulinemia. (19294010)	Alatoom A.... Wang H.Y.	2009
12	Cryoglobulinemia and renal disease. (18408474)	Alpers C.E.... Smith K.D.	2008
13	High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection. (18775023)	Antonelli A.... Ferrannini E.	2008
14	Membranoproliferative glomerulonephritis with essential cryoglobulinemia. (20142909)	Satish S.... Unni V.N.	2008
15	Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. (18292291)	Saadoun D.... Cacoub P.	2008
16	Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)	Mazzaro C.... Tirelli U.	2007
17	Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, SjAPgren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis. (17888211)	Alpa M.... Roccatello D.	2007
18	Cryoglobulinemia. (17289231)	Tedeschi A.... Morra E.	2007
19	Unusual biopsy findings in a hepatitis C-infected white man with cryoglobulinemia, purpuric rash, and renal failure. (16931228)	Mohan S.... Pogue V.A.	2006
20	Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)	Hermida Lazcano I.... Solera Santos J.	2005
21	Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)	D'Amico E.... Palazzi C.	2005
22	Images in clinical medicine. Mixed cryoglobulinemia. (15972869)	Josephsen G.	2005
23	Successful treatment of necrotizing vasculitic lesions after infusion of iloprost in a patient with cryoglobulinemia and chronic HCV infection. (16396716)	Lo Gullo R.... Bagnato G.	2005
24	Autoamputation in a patient with cryoglobulinemia. (15468383)	Overton S.D.... Johnson F.E.	2004
25	Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)	Auzerie V.... Senet P.	2003
26	HCV and renal disease: not always associated with mixed cryoglobulinemia. (14640242)	Garozzo M.... Zoccali C.	2003
27	Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)	Lamprecht P.... Gross W.L.	2000
28	Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)	Kitay-Cohen Y.... Lishner M.	2000
29	Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report. (10826861)	Sanmugarajah J.... Friedman S.	2000
30	Purplish papules on the legs. Diagnosis: type I cryoglobulinemia in association with WM. (11030777)	Weinberg J.M.... Kramer E.M.	2000
31	Transfusion-transmitted virus and mixed cryoglobulinemia. (10068427)	Cacoub P.... Musset L.	1999
32	Cryoglobulinemia. (10626153)	Dispenzieri A.... Gorevic P.D.	1999
33	Prevalence of hepatitis C virus antibodies and cryoglobulinemia in patients with leukocytoclastic vasculitis. (10026397)	GA1ngAPr E.... ArtA1z F.	1999
34	Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)	Kerr G.S.... Seeff L.B.	1997
35	Exacerbation of peripheral neuropathy during alpha-interferon therapy in a patient with mixed cryoglobulinemia and hepatitis B virus infection. (8877939)	La Civita L.... Ferri C.	1996
36	Necrotizing vasculitis associated with hepatitis C virus infection: successful treatment of vasculitis with interferon-alpha despite persistence of mixed cryoglobulinemia. (8589482)	Sepp N.T.... Vogel W.	1995
37	Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)	CuAcllar M.L.... Molina J.F.	1995
38	Natural interferon-alpha versus its combination with 6-methyl-prednisolone in the therapy of type II mixed cryoglobulinemia: a long-term, randomized, controlled study. (7524736)	Dammacco F.... Rizzi R.	1994
39	The association of hepatitis C virus with mixed cryoglobulinemia. (7969225)	Agnello V.	1994
40	Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)	Disdier P.... Weiller P.J.	1992
41	The majority of peripheral blood monoclonal IgM secreting cells are CD5 negative in three patients with mixed cryoglobulinemia. (1707697)	Pasquali J.L.... Levallois H.	1991
42	Cryoglobulinemia type II]. (2074925)	Madi N.... Schifferli J.A.	1990
43	POEMS syndrome associated with cryoglobulinemia, lymphoma, multiple seborrheic keratosis, and ichthyosis. (2848065)	Fishel B.... Yaron M.	1988
44	Lymphocyte subpopulation in essential mixed cryoglobulinemia. (3486282)	Barbieri P.... Bombardieri S.	1986
45	Respiratory insufficiency in a patient with mixed cryoglobulinemia. (7292632)	Chejfec G.... Gould V.E.	1981
46	Synovial fluid in mixed cryoglobulinemia. (737009)	Frayha R.A.	1978
47	Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. (417550)	Casali P.... Zanussi C.	1978
48	Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)	Levo Y.... Franklin E.C.	1977
49	Immune complexes and mixed cryoglobulinemia. (5458000)	Barnett E.V.... Cracchiolo A.	1970
50	Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)	ENGLE R.L.	1956

Genes related to Cryoglobulinemia

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Cryoglobulinemia:

- Elite gene

id	Symbol	Description	Score	Implication
1	CD40LG	CD40 ligand	21.27	GeneCards inferred via : Publications, Disorders (show sections)
2	TSLP	thymic stromal lymphopoietin	18.75	GeneCards inferred via : Publications, Disorders (show sections)
3	CD5	CD5 molecule	16.25	GeneCards inferred via : Publications, Disorders (show sections)
4	IFNA2	interferon, alpha 2	13.75	GeneCards inferred via : Publications, Disorders (show sections)
5	BCR	breakpoint cluster region	11.25	GeneCards inferred via : Publications, Disorders (show sections)
6	IGHM	immunoglobulin heavy constant mu	8.71	GeneCards inferred via : Publications, Disorders (show sections)
7	APOH	apolipoprotein H (beta-2-glycoprotein I)	6.21	GeneCards inferred via : Publications, Disorders (show sections)
8	CD79A	CD79a molecule, immunoglobulin-associated alpha	3.71	GeneCards inferred via : Publications, Disorders (show sections)

Products for genes related to Cryoglobulinemia disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	8	-	8	7
2	Novus Biologicals	8	8	8	-

Variations for Cryoglobulinemia

Expression for genes affiliated with Cryoglobulinemia

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

Sources:
⁴⁹PathCards, ³⁰KEGG, ⁵⁴Reactome, ⁵²QIAGEN, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Primary immunodeficiency³⁰	9.6	CD40LG, CD79A
2	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵⁴ Show member pathways FCERI mediated Ca+2 mobilization⁵⁴ FCERI mediated MAPK activation⁵⁴ B-Cell Receptor Complex⁵²	9.3	CD79A, IGHM
3	B Cell Receptor Signaling Pathway³⁷	8.9	CD79A, CD5, IGHM

Compounds for genes affiliated with Cryoglobulinemia

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁵⁰PharmGKB, ³BitterDB, ²⁵HMDB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50) (show all 74)

id	Compound	Score	Top Affiliating Genes
1	sulfolipid i⁴⁴	10.0	CD79A, CD40LG
2	sandoglobulin⁴⁴	10.0	CD40LG, CD79A
3	vancomycin⁴⁴ ¹²	11.0	CD40LG, CD79A
4	pneumococcal⁴⁴	10.0	CD79A, CD40LG
5	tuberculin⁴⁴	10.0	CD40LG, CD79A
6	chlorambucil⁴⁴ ¹²	11.0	CD40LG, IFNA2
7	praziquantel⁴⁴ ¹²	11.0	CD40LG, CD79A
8	hemocyanin⁴⁴	10.0	CD40LG, CD79A
9	fluorochrome⁴⁴	9.9	BCR, CD40LG
10	gliadin⁴⁴	9.9	CD79A, CD40LG
11	mizoribine⁴⁴	9.9	IFNA2, CD79A
12	pmma⁴⁴	9.9	CD40LG, CD79A
13	silicone⁴⁴	9.9	CD40LG, CD79A
14	busulfan⁴⁴ ⁵⁰ ¹²	11.8	BCR, IFNA2
15	mannan⁴⁴	9.8	CD79A, CD40LG
16	isotretinoin⁴⁴ ¹²	10.7	IFNA2, CD79A
17	allergens⁴⁴	9.7	TSLP, CD40LG, CD79A
18	dapsone⁴⁴ ³ ⁵⁰ ¹²	12.6	CD79A, IFNA2
19	okt3⁴⁴	9.6	CD40LG, CD79A
20	gamma globulin⁴⁴	9.6	CD79A, CD40LG, IFNA2
21	neopterin⁴⁴	9.6	CD40LG, CD79A, IFNA2
22	polyethylene glycol⁴⁴	9.6	IFNA2, CD40LG, CD79A
23	thyroxine⁴⁴ ²⁵	10.5	CD40LG, CD79A, IFNA2
24	blys⁴⁴	9.5	CD79A, BCR, CD40LG
25	gluten⁴⁴	9.5	APOH, CD79A
26	con a⁴⁴	9.5	CD79A, IFNA2
27	agar⁴⁴	9.5	CD79A, IFNA2, CD40LG
28	epinephrine⁴⁴ ²⁵ ¹²	11.4	CD40LG, IFNA2, CD79A
29	ascorbic acid⁴⁴ ²⁵	10.4	CD40LG, CD79A, IFNA2
30	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	12.4	IFNA2, CD79A, CD40LG
31	hydroxychloroquine⁴⁴ ¹²	10.3	CD40LG, IFNA2, APOH
32	cardiolipin⁴⁴ ¹²	10.2	APOH, CD40LG, CD79A
33	ivig⁴⁴	9.2	APOH, CD79A, CD40LG
34	vitamin b12⁴⁴	9.2	CD79A, CD40LG, APOH
35	folate⁴⁴	9.2	APOH, CD79A, CD40LG
36	phosphatidylserine⁴⁴ ²⁹ ¹²	11.1	APOH, CD40LG, CD79A
37	aspirin⁴⁴ ⁵⁰ ²⁹ ²⁵	12.1	CD40LG, CD79A, APOH
38	betacarotene⁴⁴	9.1	APOH, CD79A, IFNA2
39	galactose⁴⁴	9.1	APOH, IFNA2, CD79A
40	azathioprine⁴⁴ ³ ⁵⁰ ¹²	12.1	CD79A, IFNA2, APOH
41	prednisolone⁴⁴ ²⁹ ¹²	11.1	IFNA2, APOH, CD79A
42	cyclophosphamide⁴⁴ ⁵⁰ ¹²	11.1	APOH, BCR, IFNA2
43	sialic acid⁴⁴	9.0	CD79A, BCR, APOH
44	fibrinogen⁴⁴	8.9	CD40LG, CD79A, APOH
45	histamine⁴⁴ ²⁹ ²⁵	10.9	CD40LG, CD79A, IFNA2
46	vegf⁴⁴	8.7	CD40LG, IFNA2, CD79A, APOH
47	heparin⁴⁴ ²⁹ ²⁵ ¹²	11.7	CD40LG, APOH, CD79A, BCR
48	cysteine⁴⁴	8.5	CD40LG, BCR, IFNA2, CD79A
49	estrogen⁴⁴	8.4	CD40LG, IFNA2, CD79A, APOH
50	rituximab⁴⁴ ⁵⁰ ¹²	10.3	APOH, IFNA2, BCR, CD79A, CD40LG

GO Terms for genes affiliated with Cryoglobulinemia

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.9	CD40LG, CD79A, CD5
2	extracellular space	GO:005615	8.5	CD40LG, IFNA2, TSLP, APOH

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	B cell differentiation	GO:030183	9.6	CD40LG, CD79A
2	B cell proliferation	GO:042100	9.3	CD40LG, CD79A

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	9.3	CD40LG, IFNA2, TSLP

Products for genes affiliated with Cryoglobulinemia

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Cryoglobulinemia

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: CRY004 MIFTS: 58	Cryoglobulinemia malady Rare diseases, Immune diseases categories
10 drugs, 8 genes, 21 tissues, 193 related diseases, clinical trials Download this MalaCard Expand all tables

Cryoglobulinemia malady