MCID: CRY004
MIFTS: 61

Cryoglobulinemia malady

Summaries for Cryoglobulinemia

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cryoglobulinemia is a condition that can affect blood vessels throughout the body. this condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. these abnormal proteins become solid in cold temperatures and block blood flow. symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, raynaud's phenomenon, skin ulcers, and skin death. last updated: 1/23/2012

MalaCards: Cryoglobulinemia, also known as cryoimmunoglobulinaemia, is related to hepatitis and hepatitis c. An important gene associated with Cryoglobulinemia is CD40LG (CD40 ligand), and among its related pathways are Rheumatoid arthritis and Tuberculosis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds aspartate and ribavirin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and liver, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 A hypersensitivity reaction type iv disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures.

Wikipedia:63 Cryoglobulinemia is a medical condition in which the blood contains large amounts of cryoglobulins -... more...

Aliases & Classifications for Cryoglobulinemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

cryoglobulinemia 8 42 10 44 60
cryoimmunoglobulinaemia 8


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Disease Ontology8 DOID:2917
NCIt39 C26736
SNOMED-CT56 30911005
MeSH34 D003449

Related Diseases for Cryoglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Cryoglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, CXCL10
2hepatitis c31.5IFNA2, IFNA1, TNFSF13B, FAS, HLA-DRB1, CD40LG
3vasculitis31.1ENO1, CD40LG, FN1, IGHM, APOH, TNFSF13B
4glomerulonephritis30.8TSLP, CD40LG, FN1
5hepatitis b30.8IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, CXCL10
6membranoproliferative glomerulonephritis30.6TSLP, IFNA2
7myeloma30.5IFNA2, IFNA1, TNFSF13B, FAS, FASLG, IGHM
8thyroiditis30.4HLA-DRB1, FASLG, IFNA1
9cryoglobulinemic vasculitis30.4IFNA2, BCR, TSLP, ENO1, CD40LG, CD5
10arthritis30.3HLA-DRB1, FN1, CXCL10
11autoimmune hepatitis30.3IFNA1, FAS, HLA-DQB1, HLA-DRB1, CD40LG
12leukemia30.3CD27, CD40LG, CD5, FN1, HLA-DRB1, FASLG
13macroglobulinemia30.3CD5
14systemic lupus erythematosus30.2CD27, TNFSF13B
15lupus erythematosus30.2IFNA2, APOH
16chronic lymphocytic leukemia30.2BCR, CD27, CD40LG, CD5, IGHM, TNFSF13B
17rheumatoid arthritis30.2HLA-DRB1, HLA-DQB1, FASLG, FAS, APOH, TNFSF13B
18viral hepatitis30.1IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, FN1
19non-hodgkin lymphoma30.1TNFSF13B, FAS, HLA-DRB1, CD5, CD27, BCR
20liver cirrhosis30.0IFNA2, IFNA1, HLA-DRB1, CXCL10
21endocarditis29.9FN1
22polyneuropathy29.9CD40LG, IFNA2
23thrombocytopenia29.9IFNA2, IFNA1, APOH, CD40LG
24hepatocellular carcinoma29.9IFNA2, IFNA1, FAS, FASLG, HLA-DRB1, FN1
25polyarteritis nodosa29.7IFNA2
26pneumonia29.7CXCL10
27encephalitis29.7CXCL10, IFNA1
28macroglobulinemia, waldenstrom, somatic29.7CD40LG, IGHM
29antiphospholipid syndrome29.7CD40LG, APOH
30uveitis29.7CXCL10, CXCL11, IFNA2
31influenza29.7IFNA1, CD27, CXCL10
32hepatitis e29.7CD40LG
33hairy cell leukemia29.7CD5, IFNA1, IFNA2
34psoriasis29.7HLA-DRB1, FN1, CXCL10
35mycosis fungoides29.7IFNA2, IFNA1, CXCL11, CXCL10
36bronchiolitis obliterans29.7CXCL10
37lymphopenia29.7FAS, FASLG
38systemic scleroderma29.7TNFSF13B, APOH, HLA-DQB1, HLA-DRB1, CD40LG
39adenocarcinoma29.7FAS, FASLG, CXCL10, MMP7, ENO1
40retinal vasculitis29.7APOH
41periodontal disease29.7MMP7, CXCL10, FN1
42hepatitis a10.6
43neuropathy10.4
44peripheral neuropathy10.3
45hodgkin's lymphoma10.3
46multiple myeloma10.3
47liver disease10.3
48autoimmune thyroiditis10.2
49purpura10.2
50ischemia10.1

Graphical network of the top 20 diseases related to Cryoglobulinemia:



Diseases related to cryoglobulinemia

Clinical Features for Cryoglobulinemia

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Drugs & Therapeutics for Cryoglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cryoglobulinemia

Drug clinical trials:

Search ClinicalTrials for Cryoglobulinemia

Search NIH Clinical Center for Cryoglobulinemia

Search CenterWatch for Cryoglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cryoglobulinemia

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Anatomical Context for Cryoglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Cryoglobulinemia:

32
Skin, B cells, Liver, Kidney, Thyroid, Bone, Brain, Bone marrow, Endothelial, T cells, Testes, Lymph node, Lung, Heart, Smooth muscle, Monocytes, Nk cells, Small intestine, Whole blood, Colon

Animal Models for Cryoglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cryoglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.9APOH, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
2MP:00053859.9FASLG, HLA-DQB1, IGHM, FN1, CD40LG, CXCL10
3MP:00053819.9FAS, FASLG, HLA-DQB1, IGHM, MMP7, TSLP
4MP:00053979.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
5MP:00053849.7IGHM, HLA-DQB1, FASLG, FAS, TNFSF13B, FN1
6MP:00053879.7BCR, TNFSF13B, FAS, FASLG, HLA-DQB1, IGHM
7MP:00107689.4APOH, FAS, FASLG, HLA-DQB1, IGHM, FN1

Publications for Cryoglobulinemia

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50PubMed
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Articles related to Cryoglobulinemia:

(show top 50)    (show all 751)
idTitleAuthorsYear
1
WaldenstrAPm macroglobulinemia with cryoglobulinemia revealed by amorphous deposits on blood smear. (23893295)
2013
2
Imatinib therapy for non-infection-related type II cryoglobulinemia with membranoproliferative glomerulonephritis. (21982457)
2012
3
Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients. (23158135)
2012
4
Efficacy of tocilizumab in rituximab-refractory cryoglobulinemia vasculitis. (22121135)
2012
5
Cytoplasmic inclusions in leukocytes associated to cryoglobulinemia and IgG-kappa monoclonal gammapathy of undetermined significance. (21306435)
2011
6
Cryoglobulinemia in chronic hemodialysis patients. (21859249)
2011
7
POEMS syndrome: cryoglobulinemia an unusual association. (20373148)
2011
8
High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia. (19543846)
2009
9
Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemia. (18484642)
2008
10
Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia. (18558364)
2008
11
Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia. (17526550)
2008
12
Hepatitis C-associated leukocytoclastic vasculitis with anticardiolipin antibodies causing penile necrosis and deep venous thrombosis in the absence of cryoglobulinemia. (18438797)
2008
13
Non HCV-related mixed cryoglobulinemia. (17936226)
2007
14
Should rituximab be the rescue therapy for refractory mixed cryoglobulinemia associated with hepatitis C? (17557269)
2007
15
Hepatitis C Virus-related Mixed Cryoglobulinemia: Pathogenesis, Clinica Manifestations, and New Therapies. (21960882)
2007
16
Efficacy of low-dose rituximab for mixed cryoglobulinemia. (17692572)
2007
17
Life-threatening cryoglobulinemia: clinical and immunological characterization of 29 cases. (16996578)
2006
18
Transfusion medicine illustrated. Cryoglobulinemia and cutaneous vasculitis. (14962302)
2004
19
Cryoglobulinemia vasculitis following intravesical instillations of bacillus Calmette-Guerin. (15301249)
2004
20
Leg ulcers associated with cryoglobulinemia: clinical study of 15 patients and response to treatment. (12622649)
2003
21
Generalized vasculitis, thrombocytopenia, and transient lymphoproliferative disorder caused by idiopathic mixed cryoglobulinemia. (12861125)
2003
22
The significance of cryoglobulinemia in patients with chronic hepatitis B and C virus infection. (14571770)
2003
23
Spontaneous rectus sheath haematoma in HCV mixed cryoglobulinemia requiring emergency treatment (case report). (12564308)
2002
24
Hepatitis C virus (HCV)-related cryoglobulinemia after liver transplantation for HCV cirrhosis. (11875606)
2002
25
Renal involvement in monoclonal (type I) cryoglobulinemia: two cases associated with IgG3 kappa cryoglobulin. (12407656)
2002
26
Genetic predispositions for the presence of cryoglobulinemia and serum autoantibodies in Chinese patients with chronic hepatitis C. (11972876)
2002
27
Cryoglobulinemia due to chronic viral hepatitis infections is not a major problem in clinical practice. (11557330)
2001
28
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
29
Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells. (11342327)
2000
30
Lack of Fas and Fas-L mutations in patients with lymphoproliferative disorders associated with SjAPgren's syndrome and type II mixed cryoglobulinemia. (10410268)
1999
31
Interferon-alpha treatment of hepatitis C virus-associated mixed cryoglobulinemia. (9514550)
1998
32
Pattern of HCV antibodies with special reference to NS5A reactivity in HCV-infected patients: relation to viral genotype, cryoglobulinemia and response to interferon. (9566820)
1998
33
Are HLA class II and immunoglobulin constant region genes involved in the pathogenesis of mixed cryoglobulinemia type II after hepatitis C virus infection? (9696490)
1998
34
Mixed cryoglobulinemia: effect of alpha-interferon on subclinical lymphocyte alveolitis. (8737733)
1996
35
Cryoglobulinemia in hepatitis C virus chronic active hepatitis: effects of interferon-alpha therapy. (8877728)
1996
36
Cryoglobulinemia and other dysproteinemias, familial Mediterranean fever, and POEMS syndrome. (7718425)
1995
37
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection. (8730498)
1995
38
Evidence of hepatitis C virus antibodies in the cryoprecipitate of patients with mixed cryoglobulinemia. (7514225)
1994
39
Mixed cryoglobulinemia in a heroin addict. (8172217)
1994
40
Interferon for mixed cryoglobulinemia associated with hepatitis C. (1626565)
1992
41
Severe bleeding after cascade filtration apheresis for type II cryoglobulinemia-related rapidly progressive glomerulonephritis. (1300897)
1992
42
Low number of complement C3b/C4b receptors (CR1) on erythrocytes from patients with essential mixed cryoglobulinemia, systemic lupus erythematosus and rheumatoid arthritis: relationship with disease activity, anticardiolipin antibodies, complement activation and therapy. (1833542)
1991
43
Reappraisal of the clinical expression of mixed cryoglobulinemia. (3046019)
1988
44
Treatment of idiopathic mixed cryoglobulinemia with alpha interferon. (3674059)
1987
45
Long term effects of cryoapheresis and cytostatic treatment in essential mixed cryoglobulinemia. (4055106)
1985
46
Rapidly progressive glomerulonephritis in IgA/IgG cryoglobulinemia. (4058626)
1985
47
Plasma exchange in glomerulonephritis associated with systemic lupus erythematosus and essential mixed cryoglobulinemia. (6642731)
1983
48
The immunopathogenesis of glomerulonephritis associated with mixed cryoglobulinemia. (661864)
1978
49
Association between hepatitis B virus and essential mixed cryoglobulinemia. (865530)
1977
50
Chronic liver disease associated with mixed cryoglobulinemia. Review of the literature and presentation of two cases. (5085398)
1972

Genetic Variations for Cryoglobulinemia

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Expression for genes affiliated with Cryoglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryoglobulinemia

Search GEO for disease gene expression data for Cryoglobulinemia.

Pathways for genes affiliated with Cryoglobulinemia

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29KEGG, 53Reactome, 12EMD Millipore, 52R&D Systems, 55SinoBiological, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4TNFSF13B
210.3HLA-DRB1, HLA-DQB1
310.3FASLG, FAS
4
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10.3FASLG, FAS
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.2IFNA2, IFNA1, FN1
6
Apoptosis and survival Apoptotic TNF-family pathways
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10.2FAS, FASLG, CD27
710.2CXCL10, IFNA1, IFNA2
810.2CXCL10, CXCL11, FN1
9
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10.2IFNA2, IFNA1, HLA-DQB1, HLA-DRB1
10
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10.1IGHM, FASLG, FAS, IFNA1, IFNA2
11
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10.1IFNA2, IFNA1, HLA-DQB1, HLA-DRB1, IGHM, CD40LG
12
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10.0TNFSF13B, FAS, FASLG, HLA-DQB1, CD40LG, CD27
13
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10.0IFNA2, IFNA1, FAS, FASLG, CXCL11, CXCL10
14
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9.9IFNA2, IFNA1, FAS, FASLG, HLA-DQB1, HLA-DRB1
15
Hide members
9.9CD40LG, IFNA2, IFNA1, TNFSF13B, FAS, FASLG
16
Hide members
9.8IFNA1, TNFSF13B, FAS, FASLG, CD27, CXCL11

Compounds for genes affiliated with Cryoglobulinemia

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1aspartate4410.8CD40LG, FASLG
2ribavirin44 49 1112.8CD40LG, IFNA2
3ivig4410.7APOH, CD40LG
4hydroxychloroquine44 1111.7IFNA2, CD40LG, APOH
5infliximab44 49 1112.7CXCL10, APOH, IFNA2
6gliadin4410.7CD40LG
7blys4410.6TNFSF13B, BCR, CD40LG
8atpo44 2811.6IFNA1, FAS, FASLG, APOH
9serine4410.6BCR, FN1
102-chlorodeoxyadenosine4410.6CD40LG, FASLG, FAS, IFNA1
11dextran sulfate4410.6CD40LG, APOH, MMP7, FN1
12fludarabine44 1111.6FAS, CD40LG, FASLG, IFNA1
13indomethacin44 59 28 1113.6FN1
14agar4410.6FASLG, FN1, FAS
15busulfan44 1111.6IFNA2, IFNA1, BCR
16allergens4410.6TSLP, CXCL10, HLA-DRB1, CD40LG
17neopterin4410.5IFNA1, CD40LG, CXCL10, IFNA2
18cytarabine44 49 1112.5IFNA2, IFNA1, FAS, FASLG, BCR
19cyclophosphamide44 49 1112.5BCR, FASLG, APOH, IFNA2, IFNA1
20ifn-alpha4410.5IFNA2, IFNA1, FAS, CXCL10, FASLG
21teniposide44 1111.5FAS, IFNA1, FASLG
22rantes4410.5FASLG, FAS, CXCL11, CD40LG, IFNA1
23cyclosporin a44 28 5912.5CD40LG, CXCL11, FN1, IFNA1
24thalidomide44 49 59 1113.5CD40LG, IFNA2, FASLG, IFNA1
25creatinine4410.5APOH, CXCL10, ENO1, TNFSF13B, FAS
26rituximab44 49 1112.4BCR, CD40LG, FASLG, APOH, TNFSF13B, IFNA1
27paraffin4410.4FN1, FAS, FASLG, CD5, CD40LG, MMP7
28genistein44 28 59 2 11 2415.4FN1, CXCL10, FAS, FASLG, BCR, CD40LG
29polyethylene glycol4410.4IFNA1, IFNA2, CD40LG, FN1
30pegasys4410.4IFNA2, IFNA1
31doxorubicin44 49 1112.4MMP7, FN1, FAS, IFNA1, IFNA2, CD40LG
32lactate4410.4APOH, FAS, FASLG, FN1, ENO1, CD40LG
33imiquimod44 28 59 1113.4FASLG, IFNA1, IFNA2
34dexamethasone44 49 28 1113.4CD40LG, CXCL11, FN1, FASLG, IFNA1, FAS
35cisplatin44 49 59 1113.3FASLG, FN1, FAS, CD40LG, IFNA1, IFNA2
36thymidine44 2411.3CXCL10, FN1, FASLG, FAS, IFNA1, IFNA2
37phosphatidylinositol4410.3FAS, BCR, APOH, FASLG, TSLP, MMP7
38oligonucleotide4410.3BCR, MMP7, CXCL11, FASLG, HLA-DRB1, HLA-DQB1
39alanine4410.3CXCL10, IFNA2, CD40LG, FN1, HLA-DRB1, FASLG
40heparin44 28 11 2413.3FASLG, CD40LG, BCR, FAS, APOH, FN1
41cysteine4410.3FASLG, FAS, IFNA2, CD40LG, MMP7, CD27
42vegf4410.2CXCL10, MMP7, IFNA1, CD40LG, FN1, FASLG
43retinoic acid44 2411.2IFNA1, IFNA2, FAS, FN1, CD40LG, CXCL10
44arginine4410.2FAS, APOH, ENO1, HLA-DRB1, CD40LG, CXCL11
45thymidylate4410.2IFNA1, IFNA2, FAS, FASLG
46adriamycin4410.2IFNA1, FASLG, FN1, FAS
47tyrosine4410.0TSLP, BCR, FASLG, IFNA1, FAS, HLA-DQB1
48fibrinogen4410.0APOH, FN1, CD40LG, MMP7, ENO1
49prednisolone44 28 1111.9APOH, IFNA1, IFNA2, FAS
50calcium44 49 11 2412.9FASLG, CD5, CD27, CXCL11, BCR, CXCL10

GO Terms for genes affiliated with Cryoglobulinemia

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16Gene Ontology
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Cellular components related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.9CXCL10, FAS, FASLG, HLA-DRB1, CD5, CD40LG
2extracellular regionGO:0055769.8FAS, FASLG, IGHM, FN1, CD27, CXCL11
3extracellular spaceGO:0056159.4IFNA2, TNFSF13B, APOH, FASLG, FN1, CD40LG

Biological processes related to Cryoglobulinemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FASLG, FAS
2immunoglobulin secretionGO:04830510.6CD40LG, TNFSF13B
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB1, HLA-DQB1
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DQB1, HLA-DRB1
5positive regulation of endothelial cell apoptotic processGO:200035310.5CD40LG, FASLG
6negative regulation of angiogenesisGO:01652510.5APOH, FASLG, CXCL10
7T cell costimulationGO:03129510.4TNFSF13B, HLA-DQB1, HLA-DRB1, CD5
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.3FAS, FASLG
9cell-cell signalingGO:00726710.2CXCL10, CXCL11, FASLG, IFNA2
10positive regulation of leukocyte chemotaxisGO:00269010.2CXCL11, CXCL10
11immune responseGO:00695510.2CXCL10, CXCL11, IGHM, HLA-DRB1, HLA-DQB1, FASLG
12inflammatory responseGO:00695410.2CXCL10, CXCL11, CD40LG, IFNA2
13signal transductionGO:0071659.7TNFSF13B, FAS, FASLG, CXCL11, CXCL10, BCR

Molecular functions related to Cryoglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.3HLA-DRB1, HLA-DQB1
2tumor necrosis factor receptor bindingGO:00516410.2TNFSF13B, FASLG, CD40LG
3cytokine activityGO:00512510.1TSLP, CD40LG, FASLG, TNFSF13B, IFNA2
4protein bindingGO:0055159.2IFNA2, TNFSF13B, APOH, FAS, FASLG, MT1H

Products for genes affiliated with Cryoglobulinemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryoglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet