MCID: CRY007
MIFTS: 49

Cryoglobulinemia, Familial Mixed

Categories: Rare diseases, Immune diseases, Genetic diseases, Cardiovascular diseases, Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Cryoglobulinemia, Familial Mixed

MalaCards integrated aliases for Cryoglobulinemia, Familial Mixed:

Name: Cryoglobulinemia, Familial Mixed 53 69
Mixed Cryoglobulinemia 55 51 69
Essential Mixed Cryoglobulinemia 55 69
Cryoglobulinemic Vasculitis 55 69
Essential Cryoglobulinemia 55 69
Primary Cryoglobulinemia 55 69
Meltzer Syndrome 53 49
Familial Mixed Cryoglobulinemia 49
Mc 55

Characteristics:

Orphanet epidemiological data:

55
cryoglobulinemic vasculitis
Age of onset: All ages;

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
cryoglobulinemia, familial mixed:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Cryoglobulinemia, Familial Mixed

NIH Rare Diseases : 49 Familial mixed cryoglobulinemia is a rare condition that is characterized by the presence of abnormal proteins (called cryoglobulins) in the blood. These proteins clump together into a "gel-like" consistency at low temperatures, which can lead to inflammation, blocked blood vessels, and a variety of health problems. The associated signs and symptoms vary from person to person depending on which parts of the body or organ systems are affected; however, common features include purpura, joint pain, breathing problems, muscle pain, fatigue, glomerulonephritis, Raynaud's phenomenon, and skin abnormalities. The underlying genetic cause of familial mixed cryoglobulinemia is currently unknown. Although there are only a few reported families with this condition, it appears to be inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person. In severe cases, medications that suppress the immune system may be necessary. Last updated: 1/19/2016

MalaCards based summary : Cryoglobulinemia, Familial Mixed, also known as mixed cryoglobulinemia, is related to cryoglobulinemia and type ii mixed cryoglobulinemia, and has symptoms including arthralgia, myalgia and fever. An important gene associated with Cryoglobulinemia, Familial Mixed is TSLP (Thymic Stromal Lymphopoietin), and among its related pathways/superpathways are Jak-STAT signaling pathway (KEGG) and B Cell Development Pathways. The drugs Ledipasvir and Sofosbuvir have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Description from OMIM: 123550

Related Diseases for Cryoglobulinemia, Familial Mixed

Diseases in the Cryoglobulinemia, Familial Mixed family:

Mixed Cryoglobulinemia Type Iii Type Ii Mixed Cryoglobulinemia

Diseases related to Cryoglobulinemia, Familial Mixed via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 cryoglobulinemia 29.2 CD40LG CD5 IFNA2 TSLP
2 type ii mixed cryoglobulinemia 12.2
3 mixed cryoglobulinemia type iii 12.2
4 glomerulopathy with fibronectin deposits 2 11.1
5 vasculitis 10.6
6 hepatitis 10.3
7 hepatitis c 10.3
8 hepatitis c virus 10.2
9 waldenstrom macroglobulinemia 10.2 CD40LG IGHM
10 lymphoplasmacytic lymphoma 10.2 CD40LG CD5
11 kyasanur forest disease 10.2 CD40LG IFNA1
12 plasma protein metabolism disease 10.2 CD40LG CD5
13 anemia, autoimmune hemolytic 10.2 CD40LG CD5
14 fasciolopsiasis 10.2 CD40LG IFNA1
15 autoimmune disease of blood 10.2 CD40LG CD5
16 upper respiratory tract disease 10.2 CD40LG TSLP
17 spinocerebellar ataxia, autosomal recessive 10 10.2 CD40LG IFNA2
18 phlebotomus fever 10.2 CD40LG IFNA2
19 hepatitis d 10.2 CD40LG IFNA2
20 lung lymphoma 10.2 CD40LG CD5
21 marginal zone b-cell lymphoma 10.1 CD40LG CD5
22 granulomatous hepatitis 10.1 CD40LG IFNA2
23 lymphomatoid granulomatosis 10.1 IFNA1 IFNA2
24 common cold 10.1 IFNA2 TSLP
25 squamous papillomatosis 10.1 IFNA1 IFNA2
26 agammaglobulinemia, x-linked 10.1 BCR IGHM
27 discoid lupus erythematosus 10.1 IFNA1 IFNA2
28 lymphoid leukemia 10.1 BCR CD5
29 scleroderma, familial progressive 10.1
30 polyarteritis nodosa, childhood-onset 10.1
31 polyarteritis nodosa 10.1
32 chronic neutrophilic leukemia 10.1 IFNA1 IFNA2
33 leukocyte disease 10.0 CD40LG IFNA1
34 richter's syndrome 10.0 BCR CD5
35 lymphoma, mucosa-associated lymphoid type 10.0 CD40LG CD5
36 respiratory system disease 10.0 CD40LG TSLP
37 severe acute respiratory syndrome 10.0 CD40LG IFNA1
38 human immunodeficiency virus infectious disease 10.0 CD40LG IFNA1
39 hepatitis b 10.0
40 b-cell expansion with nfkb and t-cell anergy 10.0 BCR CD5
41 giardiasis 10.0 CD40LG ENO1
42 stomatitis 9.9 IFNA1 IFNA2
43 blood group--diego system 9.8
44 systemic lupus erythematosus 9.8
45 myeloma, multiple 9.8
46 membranous nephropathy 9.8
47 pulmonary hypertension 9.8
48 crest syndrome 9.8
49 mononeuropathy 9.8
50 cholecystitis 9.8

Graphical network of the top 20 diseases related to Cryoglobulinemia, Familial Mixed:



Diseases related to Cryoglobulinemia, Familial Mixed

Symptoms & Phenotypes for Cryoglobulinemia, Familial Mixed

Symptoms via clinical synopsis from OMIM:

53
Endocrine:
hypertension

Heme:
cryoglobulinemia

GU:
loss of renal function

Lab:
proteinuria
hematuria
elevated serum creatinine

Misc:
anasarca


Clinical features from OMIM:

123550

Human phenotypes related to Cryoglobulinemia, Familial Mixed:

55 31 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
2 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
3 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
4 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
5 muscle weakness 55 31 hallmark (90%) Very frequent (99-80%) HP:0001324
6 arthritis 55 31 frequent (33%) Frequent (79-30%) HP:0001369
7 splenomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0001744
8 hepatomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0002240
9 renal insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0000083
10 proteinuria 55 31 frequent (33%) Frequent (79-30%) HP:0000093
11 skin ulcer 55 31 hallmark (90%) Very frequent (99-80%) HP:0200042
12 glomerulopathy 55 31 frequent (33%) Frequent (79-30%) HP:0100820
13 keratoconjunctivitis sicca 55 31 occasional (7.5%) Occasional (29-5%) HP:0001097
14 hematuria 55 31 frequent (33%) Frequent (79-30%) HP:0000790
15 gastrointestinal hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002239
16 petechiae 55 31 hallmark (90%) Very frequent (99-80%) HP:0000967
17 vasculitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0002633
18 mediastinal lymphadenopathy 55 31 hallmark (90%) Very frequent (99-80%) HP:0100721
19 gastrointestinal infarctions 55 31 frequent (33%) Frequent (79-30%) HP:0005244
20 sensorimotor neuropathy 55 31 frequent (33%) Frequent (79-30%) HP:0007141
21 gangrene 55 31 frequent (33%) Frequent (79-30%) HP:0100758
22 cutis marmorata 55 31 hallmark (90%) Very frequent (99-80%) HP:0000965
23 cryoglobulinemia 55 31 hallmark (90%) Very frequent (99-80%) HP:0100778
24 circulating immune complexes 55 31 hallmark (90%) Very frequent (99-80%) HP:0012224
25 viral hepatitis 55 31 frequent (33%) Frequent (79-30%) HP:0006562
26 mononeuropathy 55 31 frequent (33%) Frequent (79-30%) HP:0009831
27 hypertension 31 HP:0000822
28 peripheral neuropathy 55 Frequent (79-30%)
29 purpura 55 Very frequent (99-80%)
30 elevated serum creatinine 31 HP:0003259
31 abnormality of blood and blood-forming tissues 31 HP:0001871
32 abnormality of the liver 55 Frequent (79-30%)
33 chronic kidney disease 31 HP:0012622
34 anasarca 31 HP:0012050

GenomeRNAi Phenotypes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

25 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 IFNA1 IFNA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.77 BCR IFNA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.77 BCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.77 IFNA2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.77 BCR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.77 IFNA2 BCR IFNA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.77 IFNA2 IFNA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.77 BCR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 IFNA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.77 BCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 IFNA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 IFNA2 BCR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 IFNA1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.77 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.77 IFNA1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 IFNA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.77 IFNA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 BCR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.77 IFNA1

Drugs & Therapeutics for Cryoglobulinemia, Familial Mixed

Drugs for Cryoglobulinemia, Familial Mixed (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ledipasvir Approved Phase 2, Phase 3 1256388-51-8 67505836
2
Sofosbuvir Approved Phase 2, Phase 3 1190307-88-0 45375808
3 Anti-Infective Agents Phase 2, Phase 3,Phase 1
4 Antiviral Agents Phase 2, Phase 3,Phase 1
5 Ledipasvir, sofosbuvir drug combination Phase 2, Phase 3
6
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
7
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
8
rituximab Approved Phase 2 174722-31-7 10201696
9
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
10 Anti-HIV Agents Phase 1, Phase 2
11 Anti-Retroviral Agents Phase 1, Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Antineoplastic Agents, Hormonal Phase 2
14 Antirheumatic Agents Phase 2
15 glucocorticoids Phase 2
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia Recruiting NCT02825212 Phase 2, Phase 3 Harvoni
2 Evaluation of Clinical Efficacy and Immunologic Response After IL-2 Therapy in HCV-related Vasculitis Patients Completed NCT00574652 Phase 1, Phase 2 Proleukin
3 Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis Active, not recruiting NCT02556866 Phase 2 rituximab;Prednisone;Placebo
4 Benefit of DAA Therapy in HCV Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia Completed NCT03342261 DAA treatment
5 Characterization of Clonal B Cell Populations in HCV Infection Completed NCT00435201 Not Applicable
6 Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis Recruiting NCT02856243 new antiviral therapy

Search NIH Clinical Center for Cryoglobulinemia, Familial Mixed

Genetic Tests for Cryoglobulinemia, Familial Mixed

Anatomical Context for Cryoglobulinemia, Familial Mixed

MalaCards organs/tissues related to Cryoglobulinemia, Familial Mixed:

38
Skin, Kidney, Liver, Bone

Publications for Cryoglobulinemia, Familial Mixed

Articles related to Cryoglobulinemia, Familial Mixed:

(show top 50) (show all 517)
# Title Authors Year
1
Role of ribavirin in the treatment of hepatitis C virus-associated mixed cryoglobulinemia with interferon-free regimens. ( 29318374 )
2018
2
Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection: association or causation? ( 28852522 )
2017
3
Reversion of anergy signatures in clonal CD21(low) B cells of mixed cryoglobulinemia after clearance of HCV viremia. ( 28507081 )
2017
4
Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. ( 28453396 )
2017
5
MPGN and mixed cryoglobulinemia in a patient with hepatitis C - new treatment implications and renal outcomes. ( 29098140 )
2017
6
Decline of cellular activation in non-B cells after rituximab treatment in hepatitis C-associated mixed cryoglobulinemia vasculitis. ( 27666584 )
2017
7
Lymphoproliferative disease with mixed cryoglobulinemia and hyperviscosity syndrome in an HIV-infected patient: HCV is the only culprit. ( 28825444 )
2017
8
Direct-Acting Antivirals and Mixed Cryoglobulinemia Vasculitis: Long-Term Outcome of Patients Achieving HCV Eradication. ( 29109502 )
2017
9
Micro and nanoparticles as possible pathogenetic co-factors in mixed cryoglobulinemia. ( 27694373 )
2017
10
Mixed cryoglobulinemia: a diagnostic and therapeutic challenge. ( 28490478 )
2017
11
Thyroid Involvement in Hepatitis C Virus-Infected Patients with/without Mixed Cryoglobulinemia. ( 28736547 )
2017
12
Efficacy of Cryofiltration for Treatment of Mixed Cryoglobulinemia: A Report of Four Cases. ( 28661098 )
2017
13
Recurrent Mixed Cryoglobulinemia Despite Sustained Virologic Response to Treatment: A Case Report. ( 28343737 )
2017
14
Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia. ( 28291241 )
2017
15
Mixed cryoglobulinemia-associated SjAPgren's syndrome leading to spontaneous rupture of the kidney: a case report. ( 27042145 )
2016
16
Successful Treatment With Bosentan for Digital Ulcers Related to Mixed Cryoglobulinemia: A Case Report. ( 26785421 )
2016
17
Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study. ( 27161362 )
2016
18
A Rare Cause of Unilateral Central Retinal Vein Occlusion in a Young Patient: Type III Mixed Cryoglobulinemia. ( 27418988 )
2016
19
Successful ledipasvira88+a88sofosbuvir treatment of active synovitis in a rheumatoid arthritis patient with hepatitis C virus-related mixed cryoglobulinemia. ( 27848256 )
2016
20
Vitamin D pathway gene polymorphisms as predictors of hepatitis C virus-related mixed cryoglobulinemia. ( 27139837 )
2016
21
Incidence of thyroid disorders in mixed cryoglobulinemia: Results from a longitudinal follow-up. ( 26970485 )
2016
22
Annular leukocytoclastic vasculitis associated with essential mixed cryoglobulinemia. ( 27098553 )
2016
23
Hepatic and Mesenteric Vasculitis as Presenting Manifestation of Mixed Cryoglobulinemia Related to Chronic Hepatitis C Virus Infection in a Female Patient. ( 27219310 )
2016
24
The possible persistence of mixed cryoglobulinemia stigmata in spite of viral eradication: Insufficient or too late antiviral treatment? ( 27943334 )
2016
25
Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study. ( 26853322 )
2016
26
Prospective study of guideline-tailored therapy with direct-acting antivirals for hepatitis C virus-associated mixed cryoglobulinemia. ( 27483451 )
2016
27
Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents. ( 26474537 )
2015
28
Role of IL28B genotyping in patients with hepatitis C virus-associated mixed cryoglobulinemia and response to PEG-IFN and ribavirin treatment. ( 26060059 )
2015
29
Abnormal CD4a88+a88T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection. ( 26129991 )
2015
30
Persistence of mixed cryoglobulinemia despite cure of hepatitis C with new oral antiviral therapy including direct-acting antiviral sofosbuvir: A case series. ( 25746436 )
2015
31
Treatment of HCV-related mixed cryoglobulinemia. ( 26302805 )
2015
32
Early onset mixed cryoglobulinemia in hepatitis C. ( 26275272 )
2015
33
The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation. ( 25452118 )
2015
34
Pulmonary Extranodal Marginal Zone Lymphoma with Macroglobulinemia and Mixed Cryoglobulinemia Developed in a Patient with Chronic Hepatitis C. ( 26278303 )
2015
35
Recurrent Mixed Cryoglobulinemia (MCS): A Case Report and Literature Review. ( 26422544 )
2015
36
Long-term effect of HCV eradication in patients with mixed cryoglobulinemia: A prospective, controlled, open-label, cohort study. ( 25431357 )
2015
37
Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients. ( 25800158 )
2015
38
Combined treatment with antiviral therapy and rituximab in patients with mixed cryoglobulinemia: review of the literature and report of a case using direct antiviral agents-based antihepatitis C virus therapy. ( 25815218 )
2015
39
Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review. ( 26031898 )
2015
40
Vasculitis with renal involvement in essential mixed cryoglobulinemia: Case report and mini-review. ( 24868518 )
2014
41
Peg-IFNI+Ribavirin/Protease inhibitor combination in severe hepatitis C virus associated mixed cryoglobulinemia vasculitis. ( 25135864 )
2014
42
Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia. ( 24636026 )
2014
43
Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey. ( 24418300 )
2014
44
Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia. ( 24722124 )
2014
45
Essential mixed cryoglobulinemia manifesting as recurrent perioral edema: report of a case. ( 24332336 )
2014
46
Purpura with ulcerative skin lesions and mixed cryoglobulinemia in a quiescent hepatitis B virus carrier. ( 24429450 )
2014
47
Chronic HCV infection and lymphoproliferative disorders: mixed cryoglobulinemia syndrome, MGUS and B-cell non-Hodgkin lymphoma. ( 25351042 )
2014
48
Treatment of chronic hepatitis C complicated by mixed cryoglobulinemia with new protease inhibitor, sofosbuvir. ( 25038237 )
2014
49
Cell surface expression of activating receptors and co-receptors on peripheral blood NK cells in mixed cryoglobulinemia. ( 23276527 )
2013
50
Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10. ( 23902475 )
2013

Variations for Cryoglobulinemia, Familial Mixed

Expression for Cryoglobulinemia, Familial Mixed

Search GEO for disease gene expression data for Cryoglobulinemia, Familial Mixed.

Pathways for Cryoglobulinemia, Familial Mixed

Pathways related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.18 IFNA1 IFNA2 TSLP
2 10.88 CD40LG CD5
3 10.58 IFNA1 IFNA2

GO Terms for Cryoglobulinemia, Familial Mixed

Cellular components related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD40LG CD5 IGHM
2 extracellular space GO:0005615 9.1 CD40LG ENO1 IFNA1 IFNA2 IGHM TSLP

Biological processes related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 T cell costimulation GO:0031295 9.52 CD40LG CD5
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 IFNA2 TSLP
3 type I interferon signaling pathway GO:0060337 9.49 IFNA1 IFNA2
4 humoral immune response GO:0006959 9.48 IFNA1 IFNA2
5 response to exogenous dsRNA GO:0043330 9.46 IFNA1 IFNA2
6 regulation of receptor activity GO:0010469 9.46 CD40LG IFNA1 IFNA2 TSLP
7 regulation of type I interferon-mediated signaling pathway GO:0060338 9.43 IFNA1 IFNA2
8 positive regulation of interleukin-10 production GO:0032733 9.4 CD40LG TSLP
9 T cell activation involved in immune response GO:0002286 9.37 IFNA1 IFNA2
10 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.32 IFNA1 IFNA2
11 natural killer cell activation involved in immune response GO:0002323 9.26 IFNA1 IFNA2
12 B cell differentiation GO:0030183 9.13 CD40LG IFNA1 IFNA2
13 B cell proliferation GO:0042100 8.8 CD40LG IFNA1 IFNA2

Molecular functions related to Cryoglobulinemia, Familial Mixed according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IFNA1 IFNA2
2 type I interferon receptor binding GO:0005132 8.96 IFNA1 IFNA2
3 cytokine activity GO:0005125 8.92 CD40LG IFNA1 IFNA2 TSLP

Sources for Cryoglobulinemia, Familial Mixed

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