MCID: CRY005
MIFTS: 50

Cryptococcosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Cryptococcosis

MalaCards integrated aliases for Cryptococcosis:

Name: Cryptococcosis 12 50 56 52 3 3 42 14
Infection by Cryptococcus Neoformans 69
Cryptococcus Neoformans Infection 12
Busse-Buschke's Disease 12
European Cryptococcosis 12
Cryptococcal Infection 12
Torulosis 12
Torula 12

Characteristics:

Orphanet epidemiological data:

56
cryptococcosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12053
ICD10 33 B45 B45.9
ICD9CM 35 117.5
MeSH 42 D003453
NCIt 47 C2967
Orphanet 56 ORPHA1546
MESH via Orphanet 43 D003453
UMLS via Orphanet 70 C0010414
ICD10 via Orphanet 34 B45.0 B45.1 B45.2 more
UMLS 69 C0010414

Summaries for Cryptococcosis

CDC : 3 C. gattii infection is reportable in some states. Healthcare providers, please click here for more information about how to report cases.

MalaCards based summary : Cryptococcosis, also known as infection by cryptococcus neoformans, is related to lymphoma and systemic lupus erythematosus. An important gene associated with Cryptococcosis is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Disease Ontology : 12 An opportunistic mycosis that results_in fungal infection and has material basis in Cryptococcus neoformans or Cryptococcus gattii.

Wikipedia : 72 Cryptococcosis, also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused... more...

Related Diseases for Cryptococcosis

Diseases related to Cryptococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
id Related Disease Score Top Affiliating Genes
1 lymphoma 30.0 IFNG IL4 TLR9
2 systemic lupus erythematosus 28.2 FCGR2A FCGR3A FCGR3B IFNG IL4 MBL2
3 cryptococcal meningitis 11.2
4 vitamin k deficiency hemorrhagic disease 10.7 FCGR3A FCGR3B
5 rett syndrome, congenital variant 10.6 FCGR3A FCGR3B
6 maple bark strippers' lung 10.6 FCGR3A FCGR3B
7 tracheal calcification 10.6 MBL2 TLR9
8 uterine ligament endometrioid adenocarcinoma 10.6 FCGR2A FCGR3A
9 myoclonic astatic epilepsy 10.6 IFNG IL4
10 mucositis 10.5 MBL2 TLR9
11 hereditary choroidal atrophy 10.5 IFNG TLR9
12 eye accommodation disease 10.5 IFNG IL4
13 cutaneous candidiasis 10.5 IFNG MBL2
14 thelaziasis 10.5 IFNG IL4
15 goat milk allergy 10.5 IFNG IL4
16 x-linked intellectual disability, van esch type 10.5 IFNG IL4
17 duodenal somatostatinoma 10.5 FCGR3A FCGR3B
18 dental pulp necrosis 10.4 IFNG UNC119
19 tinea barbae 10.4 IFNG MBL2 TLR9
20 hypercalcinuria macular coloboma 10.4 IFNG IL4
21 centronuclear myopathy 5 10.4 IFNG IL4
22 oropharyngeal cancer, childhood 10.4 IFNG IL4
23 lymphocytic colitis 10.4 IFNG IL4
24 geniculate ganglionitis 10.3 FCGR2A IFNG TLR9
25 acute gonococcal prostatitis 10.3 IFNG IL4
26 diamond-blackfan anemia 1 10.3 FCGR2A SELL TLR9
27 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.3 IFNG IL4
28 gonadal disease 10.3 IFNG IL4 MBL2
29 childhood testicular mixed germ cell tumor 10.3 IFNG SELL UNC119
30 achard syndrome 10.3 FCGR3A FCGR3B
31 phlyctenulosis 10.3 IL4 MBL2
32 fibrous histiocytoma 10.3 FCGR3A IFNG IL4
33 childhood brain stem glioma 10.2 IFNG IL4
34 goodpasture syndrome 10.2 IFNG MBL2 SELL TLR9
35 tularemia 10.2 IFNG IL4 TLR9
36 acute vascular insufficiency of intestine 10.2 IFNG IL4 TLR9
37 legionellosis 10.2 IFNG IL4 TLR9
38 neonatal meningitis 10.2 FCGR2A MBL2
39 acute interstitial pneumonia 10.2 IFNG IL4 TLR9
40 fuchs' heterochromic uveitis 10.2 IFNG IL4 TLR9
41 opportunistic bacterial infectious disease 10.2 IFNG IL4 TLR9
42 dengue disease 10.2 IFNG IL4 TLR9
43 mucocutaneous leishmaniasis 10.2 IFNG IL4 TLR9
44 malignant hyperthermia 10.2 IFNG IL4 TLR9
45 middle lobe syndrome 10.2 IFNG IL4 TLR9
46 hypervitaminosis d 10.2 IFNG IL4 TLR9
47 mesenchymal cell neoplasm 10.2 IFNG IL4 TLR9
48 acute chest syndrome 10.1 IFNG IL4 TLR9
49 inner ear disease 10.1 IFNG IL4 TLR9
50 central sleep apnea 10.1 IFNG IL4 TLR9

Comorbidity relations with Cryptococcosis via Phenotypic Disease Network (PDN):


Acute Cystitis Cryptococcal Meningitis
Deficiency Anemia

Graphical network of the top 20 diseases related to Cryptococcosis:



Diseases related to Cryptococcosis

Symptoms & Phenotypes for Cryptococcosis

GenomeRNAi Phenotypes related to Cryptococcosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 IL4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.64 MBL2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.64 MBL2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.64 CGB3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.64 CARD9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.64 CARD9
7 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.64 CARD9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.64 IL4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.64 MBL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 MBL2 CARD9
11 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.64 IL4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.64 CARD9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.64 CGB3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.64 CARD9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.64 IL4 MBL2 CARD9 CGB3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.64 MBL2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 IL4

MGI Mouse Phenotypes related to Cryptococcosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CARD9 CLEC6A FCGR2A FCGR3B IFNG IL4
2 immune system MP:0005387 9.28 IFNG IL4 MBL2 SELL TLR9 CARD9

Drugs & Therapeutics for Cryptococcosis

Drugs for Cryptococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Fluconazole Approved Phase 4,Phase 3,Phase 2,Phase 1 86386-73-4 3365
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
6
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
7
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
8
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
9
Zidovudine Approved Phase 4 30516-87-1 35370
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Liposomal amphotericin B Phase 4,Phase 3,Phase 1,Phase 2
16 Pharmaceutical Solutions Phase 4,Phase 3
17 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2
18 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
19 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
20 Hormones Phase 4,Phase 3,Phase 2,Phase 1
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
22 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Hydroxyitraconazole Phase 4,Phase 3,Phase 2
25 Anti-HIV Agents Phase 4
26 Anti-Retroviral Agents Phase 4
27 Antiviral Agents Phase 4,Phase 2
28 Cytochrome P-450 CYP3A Inducers Phase 4
29 Nucleic Acid Synthesis Inhibitors Phase 4
30 Reverse Transcriptase Inhibitors Phase 4
31
Flucytosine Approved Phase 2, Phase 3 2022-85-7 3366
32
Posaconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 171228-49-2 147912
33
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
34
Sertraline Approved Phase 3 79617-96-2 68617
35 Antimetabolites Phase 2, Phase 3
36 Antidepressive Agents Phase 3
37 Neurotransmitter Agents Phase 3
38 Neurotransmitter Uptake Inhibitors Phase 3
39 Psychotropic Drugs Phase 3
40
Serotonin Phase 3 50-67-9 5202
41 Serotonin Agents Phase 3
42 Serotonin Uptake Inhibitors Phase 3
43
deoxycholic acid Approved Phase 1, Phase 2 83-44-3 222528
44
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
45
Tamoxifen Approved Phase 2 10540-29-1 2733526
46 Amphotericin B, deoxycholate drug combination Phase 1, Phase 2
47 Gastrointestinal Agents Phase 2
48 Antiemetics Phase 2
49 Anti-Inflammatory Agents Phase 2
50 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:

(show top 50) (show all 57)

id Name Status NCT ID Phase Drugs
1 Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex Completed NCT01656382 Phase 4 ABLC
2 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
3 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
4 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
5 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
6 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
7 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Not yet recruiting NCT02686853 Phase 4 Liposomal amphotericin B
8 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis Unknown status NCT01125644 Phase 3 SPK-843
9 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3 Posaconazole
10 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
11 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
12 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
13 Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS Completed NCT00001017 Phase 3 Fluconazole;Amphotericin B
14 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
15 Cryptococcal Antigen Screening Plus Sertraline Recruiting NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
16 Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Active, not recruiting NCT01715922 Phase 2, Phase 3 Fluconazole;Flucytosine
17 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Active, not recruiting NCT01802385 Phase 3 Sertraline
18 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
19 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
20 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
21 Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Completed NCT00145249 Phase 2 Amphotericin B;Fluconazole
22 Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis Completed NCT00012467 Phase 2 Itraconazole;Flucytosine;Fluconazole;Amphotericin B;Interferon gamma-1b
23 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
24 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00847678 Phase 2
25 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00324025 Phase 2 Mycograb;placebo
26 SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy Completed NCT00000677 Phase 1 SCH 39304
27 The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis Completed NCT00002316 Phase 1 Lobradimil;Amphotericin B
28 Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report Recruiting NCT02955862 Phase 1
29 Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis Unknown status NCT02136030 Liposomal amphotericin B;Amphotericin B-deoxycholate
30 Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection Completed NCT00001701
31 A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00000639 Itraconazole;Flucytosine;Fluconazole;Amphotericin B
32 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Itraconazole
33 Nevirapine Levels and Fluconazole Completed NCT00309582
34 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS Completed NCT00002294 Fluconazole
35 Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00000708 Flucytosine;Fluconazole;Amphotericin B
36 A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis. Completed NCT00002113 Flucytosine;Fluconazole
37 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B Completed NCT00002306 Fluconazole
38 Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002076 Fluconazole
39 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome Completed NCT00002074 Fluconazole;Amphotericin B
40 Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00002019 Amphotericin B, Lipid-based;Amphotericin B
41 A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis Completed NCT00002305 Flucytosine;Fluconazole;Amphotericin B
42 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002075 Flucytosine;Fluconazole;Amphotericin B
43 A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002068 Fluconazole;Amphotericin B
44 An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002077 Fluconazole
45 Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002040 Fluconazole
46 Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral Therapy Completed NCT02098525
47 Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa Completed NCT00830856 Fluconazole;Fixed dose - Stavudine, lamivudine and Nevirapine;Fixed dose - Stavudine, Lamivudine, Nevirapine
48 Evaluation and Follow-up of Patients With Cryptococcosis Recruiting NCT00001352
49 Idiopathic CD4 Lymphocytopenia Recruiting NCT02113930
50 Vicente Ferrer HIV Cohort Study Recruiting NCT02454569

Search NIH Clinical Center for Cryptococcosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: cryptococcosis

Genetic Tests for Cryptococcosis

Anatomical Context for Cryptococcosis

MalaCards organs/tissues related to Cryptococcosis:

39
Lung, Liver, Testes, Bone, Brain, T Cells, Bone Marrow

Publications for Cryptococcosis

Articles related to Cryptococcosis:

(show top 50) (show all 663)
id Title Authors Year
1
Cryptococcus (Cryptococcosis), Cutaneous ( 28846364 )
2017
2
Cryptococcosis mimicking lung carcinoma with brain metastases in an immunocompetent patient. ( 27769644 )
2017
3
Fluconazole Non-susceptible Cryptococcus neoformans, Relapsing/Refractory Cryptococcosis and Long-term Use of Liposomal Amphotericin B in an AIDS Patient. ( 28656554 )
2017
4
Cryptococcus (Cryptococcosis) ( 28613714 )
2017
5
Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis. ( 28831671 )
2017
6
Cryptococcosis in HIV-negative Patients with Renal Dialysis: A Retrospective Analysis of Pooled Cases. ( 28667348 )
2017
7
First report of canine systemic cryptococcosis owing to Cryptococcus gattii in Europe. ( 27868198 )
2017
8
Disseminated Cryptococcosis in an Immunocompetent Child. ( 28044302 )
2017
9
Image Gallery: Cutaneous presentation of disseminated cryptococcosis in a patient with undiagnosed HIV infection. ( 28940286 )
2017
10
Disseminated cryptococcosis presenting as cellulitis. ( 27779149 )
2017
11
Disseminated Cryptococcosis Mimicking Miliary Tuberculosis with Generalized Lymphadenopathy in Immunocompetent Host. ( 28782323 )
2017
12
Cryptococcosis in Patients with Nephrotic Syndrome: A Pooled Analysis of Cases. ( 28054218 )
2017
13
Atypical Morphology and Disparate Speciation in a Case of Feline Cryptococcosis. ( 28756537 )
2017
14
Cryptococcosis in patients with diabetes mellitus II in mainland China: 1993-2015. ( 28857298 )
2017
15
Unusual case of coexistent pulmonary cryptococcosis and tuberculosis in an immuno-competent host. ( 28709495 )
2017
16
First report of two cases of cryptococcosis in Tripoli, Libya, infected with Cryptococcus neoformans isolates present in the urban area. ( 28576330 )
2017
17
Disseminated cryptococcosis in an immunocompetent patient. ( 28720691 )
2017
18
Pulmonary Cryptococcosis Presenting With Lung Mass: Report of 7 Cases and Review of Literature. ( 28814908 )
2017
19
High-dose fluconazole in combination with amphotericin B is more efficient than monotherapy in murine model of cryptococcosis. ( 28680034 )
2017
20
Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016. ( 28831193 )
2017
21
Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients. ( 28750078 )
2017
22
Pulmonary cryptococcosis in a ruxolitinib-treated patient with primary myelofibrosis. ( 28721333 )
2017
23
Pleuro-pulmonary Cryptococcosis without Pleural Effusion. ( 28792175 )
2017
24
Cryptococcosis in patients with hematological diseases: a 14-year retrospective clinical analysis in a Chinese tertiary hospital. ( 28673256 )
2017
25
Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children's Hospital, 2002-2014. ( 28776195 )
2017
26
Paracoccidioidomycosis and cryptococcosis with localized skin manifestations: report of two cases in the elderly. ( 27192530 )
2016
27
Changing epidemiology of HIV-associated cryptococcosis in sub-Saharan Africa. ( 27477977 )
2016
28
The celecoxib derivative AR-12 has broad spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis. ( 27645246 )
2016
29
Disseminated cryptococcosis in an immunocompetent child. ( 27852678 )
2016
30
Cryptococcosis in anti-interferon-gamma autoantibodies-positive patients: a different clinical manifestation from HIV-infected patients. ( 27169938 )
2016
31
Clinical analysis of non-AIDS patients pathologically diagnosed with pulmonary cryptococcosis. ( 27867557 )
2016
32
A subdose of fluconazole alters the virulence of Cryptococcus gattii during murine cryptococcosis and modulates type I interferon expression. ( 27486215 )
2016
33
Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil. ( 27458037 )
2016
34
Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis. ( 26607986 )
2016
35
Disseminated Cryptococcosis Due to Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in the Absence of Pulmonary Alveolar Proteinosis. ( 28013480 )
2016
36
The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis). ( 27880667 )
2016
37
Cryptococcosis - The Impact of Delay to Diagnosis. ( 27172806 )
2016
38
Lung epithelium is the major source of IL-33 and is regulated by IL-33-dependent and IL-33-independent mechanisms in pulmonary cryptococcosis. ( 27596810 )
2016
39
Intestinal Lesion in a Dog Due to Cryptococcus gattii Type VGII and Review of Published Cases of Canine Gastrointestinal Cryptococcosis. ( 27988905 )
2016
40
Integrated therapy for HIV and cryptococcosis. ( 27906037 )
2016
41
Diabetes mellitus is associated with acquisition and increased mortality in HIV-uninfected patients with cryptococcosis: A population-based study. ( 26920792 )
2016
42
End-Stage Liver Disease Is a Strong Predictor of Early Mortality in Cryptococcosis. ( 26835475 )
2016
43
Primary cutaneous cryptococcosis during infliximab therapy. ( 27637071 )
2016
44
Equine Pulmonary Cryptococcosis: A Comparative Literature Review and Evaluation of Fluconazole Monotherapy. ( 27655152 )
2016
45
Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses. ( 27169478 )
2016
46
Immune reconstitution inflammatory syndrome, with pulmonary and neurological cryptococcosis, in an HIV-negative patient. ( 28057973 )
2016
47
Disseminated cryptococcosis presenting as mediastinal and hilar lymphadenopathy in an immunocompetent patient. ( 27512567 )
2016
48
A case of pulmonary cryptococcosis with large pericardial effusion diagnosed using cervical lymph node biopsy. ( 27873481 )
2016
49
Pharmacokinetics/pharmacodynamic correlations of fluconazole in murine model of cryptococcosis. ( 27235581 )
2016
50
Cryptococcosis and tuberculosis co-infection in mainland China. ( 27599473 )
2016

Variations for Cryptococcosis

Expression for Cryptococcosis

Search GEO for disease gene expression data for Cryptococcosis.

Pathways for Cryptococcosis

Pathways related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CARD9 CLEC6A FCGR2A FCGR3A FCGR3B IFNG
2 12.32 CARD9 IFNG IL4 TLR9
3
Show member pathways
12.29 FCGR3A FCGR3B IFNG IL4
4
Show member pathways
11.95 IFNG IL4 TLR9
5
Show member pathways
11.93 FCGR2A FCGR3A FCGR3B IFNG IL4
6 11.89 FCGR2A FCGR3A FCGR3B MBL2
7 11.79 FCGR2A IFNG IL4
8 11.78 FCGR2A FCGR3A FCGR3B IFNG
9 11.69 FCGR2A IFNG IL4 SELL
10 11.69 CARD9 FCGR2A FCGR3A FCGR3B IFNG TLR9
11
Show member pathways
11.68 IFNG IL4 TLR9
12 11.58 FCGR2A FCGR3B TLR9
13 11.51 IFNG SELL TLR9
14 11.2 FCGR2A FCGR3A FCGR3B MBL2
15 11.04 IFNG IL4
16 10.96 IFNG IL4
17 10.87 FCGR2A FCGR3A FCGR3B IL4 TLR9

GO Terms for Cryptococcosis

Cellular components related to Cryptococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 9.13 FCGR2A FCGR3B SELL
2 external side of plasma membrane GO:0009897 8.92 FCGR3A IFNG IL4 SELL

Biological processes related to Cryptococcosis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.81 CARD9 CLEC6A MBL2 TLR9
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.67 CARD9 CLEC6A TLR9
3 positive regulation of interleukin-12 production GO:0032735 9.48 IFNG TLR9
4 positive regulation of interleukin-10 production GO:0032733 9.46 IL4 TLR9
5 defense response to protozoan GO:0042832 9.43 IFNG IL4
6 negative regulation of growth of symbiont in host GO:0044130 9.4 IFNG MBL2
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 IFNG IL4
8 positive regulation of chemokine biosynthetic process GO:0045080 9.32 IFNG IL4
9 regulation of immune response GO:0050776 9.26 FCGR3A IFNG IL4 SELL
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IFNG IL4
11 positive regulation of immunoglobulin production GO:0002639 8.96 IL4
12 positive regulation of tumor necrosis factor production GO:0032760 8.8 CARD9 IFNG TLR9

Molecular functions related to Cryptococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.8 FCGR2A FCGR3A FCGR3B

Sources for Cryptococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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