MCID: CRY001
MIFTS: 41

Cryptogenic Organizing Pneumonia

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Cryptogenic Organizing Pneumonia

MalaCards integrated aliases for Cryptogenic Organizing Pneumonia:

Name: Cryptogenic Organizing Pneumonia 12 50 56 42 14
Bronchiolitis Obliterans Organizing Pneumonia 12 50 56 69
Constrictive Bronchiolitis 50 69
Boop 12 50
Cop 50 56
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 12
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 50
Cryptogenic Organizing Pneumonitis 12
Organizing Pneumonia 50
Organized Pneumonia 69
Idiopathic Boop 50

Characteristics:

Orphanet epidemiological data:

56
cryptogenic organizing pneumonia
Inheritance: Not applicable; Prevalence: 1-9/100000 (Iceland); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:0050157
ICD10 33 J84.116
ICD9CM 35 516.36
MeSH 42 D018549
NCIt 47 C62586
SNOMED-CT 64 129458007
Orphanet 56 ORPHA1302
MESH via Orphanet 43 D018549
UMLS via Orphanet 70 C0242770
ICD10 via Orphanet 34 J84.1
UMLS 69 C0242770

Summaries for Cryptogenic Organizing Pneumonia

NIH Rare Diseases : 50 bronchiolitis obliterans organizing pneumonia (boop) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). boop typically develops in individuals between 40-60 years old; however the disorder may affect individuals of any age. the signs and symptoms of boop vary but often include shortness of breath, a dry cough, and fever. boop can be caused by viral infections, various drugs, and other medical conditions. if the cause is known, the condition is called secondary boop. in many cases, the underlying cause of boop is unknown. these cases are called idiopathic boop or cryptogenic organizing pneumonia. treatment often includes corticosteroid medications. last updated: 2/16/2016

MalaCards based summary : Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to idiopathic interstitial pneumonia and bronchiolitis obliterans with obstructive pulmonary disease. An important gene associated with Cryptogenic Organizing Pneumonia is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. The drugs Azithromycin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and neutrophil.

Disease Ontology : 12 An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

Wikipedia : 72 Bronchiolitis obliterans organizing pneumonia (BOOP), also known as cryptogenic organizing pneumonia, is... more...

Related Diseases for Cryptogenic Organizing Pneumonia

Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 idiopathic interstitial pneumonia 11.1
2 bronchiolitis obliterans with obstructive pulmonary disease 10.8
3 pneumonia 10.7
4 ichthyosis, congenital, autosomal recessive 12 10.7 CXCL8 MMP9
5 drug rash with eosinophilia and systemic symptoms 10.6 CXCL8 MMP9
6 common variable immunodeficiency 10.6 MMP9 TIMP1
7 follicular mucinosis 10.6 CXCL8 MMP9
8 tricho onychic dysplasia 10.6 CXCL8 MMP9
9 immunodeficiency 27b, mycobacteriosis, ad 10.6 MMP9 TIMP1
10 tumefactive multiple sclerosis 10.6 CXCL8 MMP9
11 cecum adenoma 10.6 MMP9 TIMP1
12 spindle epithelial tumor with thymus-like differentiation tumor 10.6 MMP9 TIMP1
13 mycobacterium gordonae 10.6 CXCL8 MMP9
14 ulnar neuropathy 10.6 MMP9 TIMP1
15 charcot-marie-tooth disease, axonal, type 2cc 10.6 MMP9 TIMP1
16 colon squamous cell carcinoma 10.5 MMP9 TIMP1
17 myopathy 10.5 CXCL8 MMP9
18 steatorrhea 10.5 CXCL8 TIMP1
19 breast adenomyoepithelioma 10.5 MMP9 TIMP1
20 limbic encephalitis 10.5 MMP9 TNC
21 burns 10.5 CXCL8 TIMP1
22 rare endometriosis 10.5 MMP9 TIMP1
23 ophthalmia neonatorum 10.4 CXCL8 PIK3C2A
24 exophthalmos 10.4 CXCL8 PIK3C2A
25 idiopathic corneal edema 10.4 CXCL8 TNC
26 mastoiditis 10.4 MMP9 TIMP1
27 neuropathy, hereditary sensory and autonomic, type vi 10.4 CXCL8 MMP9
28 pulmonary sarcoidosis 10.4 MMP9 TIMP1
29 testicular infarct 10.4 CXCL8 MUC5B
30 glossopharyngeal nerve disease 10.3 MMP9 TIMP1
31 neonatal period electroclinical syndrome 10.3 CXCL8 MMP9
32 optic atrophy 2 10.3 MUC5B TNC
33 atrophy of prostate 10.3 CXCL8 PIK3C2A
34 intra-abdominal lymph node mast cell malignancy 10.3 CXCL8 MMP9
35 dehydration polycythemia 10.3 CXCL8 MUC5B
36 lung papillary adenocarcinoma 10.3 CXCL8 MMP9 TIMP1
37 endocervical type cervical mucinous adenocarcinoma 10.3 CXCL8 MMP9 TIMP1
38 burn scar 10.3 CXCL8 MMP9 TIMP1
39 vulva fibroepithelial polyp 10.3 CXCL8 MMP9 TIMP1
40 inappropriate adh syndrome 10.3 CXCL8 MMP9 TIMP1
41 spinal stenosis 10.3 CXCL8 MMP9
42 pelvic varices 10.3 CXCL8 MUC5B
43 esophagus leiomyoma 10.2 CXCL8 MUC1
44 germ cell and embryonal cancer 10.2 CXCL8 MMP9
45 mucoepidermoid esophageal carcinoma 10.2 MUC1 MUC5B
46 cystitis 10.2 MMP9 MUC1
47 bestiality 10.2 MUC1 MUC5B
48 sheehan syndrome 10.1 CXCL8 MMP9 PIK3C2A
49 acute chest syndrome 10.1 CXCL8 MMP9 MUC5B
50 acute dacryoadenitis 10.1 MUC1 MUC5B

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to Cryptogenic Organizing Pneumonia

Symptoms & Phenotypes for Cryptogenic Organizing Pneumonia

Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

Drugs for Cryptogenic Organizing Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 2 83905-01-5 55185 53477736 447043
2
Budesonide Approved Phase 2 51333-22-3 63006 5281004
3
Montelukast Approved Phase 2 158966-92-8 5281040
4
Oseltamivir Approved Phase 2 204255-11-8, 196618-13-0 65028
5
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
6
Ribavirin Approved Phase 2 36791-04-5 37542
7 Antibodies Phase 2
8 Immunoglobulins Phase 2
9 Anti-Asthmatic Agents Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Antipyretics Phase 2
13 Budesonide, Formoterol Fumarate Drug Combination Phase 2
14 Formoterol Fumarate Phase 2
15 gamma-Globulins Phase 2
16 glucocorticoids Phase 2
17 Hormone Antagonists Phase 2
18 Hormones Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Immunoglobulins, Intravenous Phase 2
21 Leukotriene Antagonists Phase 2
22 Respiratory System Agents Phase 2
23 Rho(D) Immune Globulin Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Recruiting NCT02036970 Phase 2 Bardoxolone methyl;Placebo
2 Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant Terminated NCT01432080 Phase 2 Prednisone;Azithromycin;Montelukast;Symbicort
3 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416
4 Lung MRI in the Management of Idiopathic Pulmonary Fibrosis Recruiting NCT03078426

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Cochrane evidence based reviews: cryptogenic organizing pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

Anatomical Context for Cryptogenic Organizing Pneumonia

MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

39
Lung, Breast, Neutrophil, Colon, Kidney

Publications for Cryptogenic Organizing Pneumonia

Articles related to Cryptogenic Organizing Pneumonia:

(show top 50) (show all 92)
id Title Authors Year
1
Cryptogenic Organizing Pneumonia With Lung Nodules Secondary to Pulmonary Manifestation of Crohn Disease. ( 28579861 )
2017
2
Retrospective evaluation of patients with organizing pneumonia: is cryptogenic organizing pneumonia different from secondary organizing pneumonia? ( 28621243 )
2017
3
Radial Probe Endobronchial Ultrasound-guided Lung Biopsy for Histopathological Diagnosis of Cryptogenic Organizing Pneumonia. ( 28091418 )
2017
4
Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia. ( 28348912 )
2017
5
Cicatricial variant of cryptogenic organizing pneumonia. ( 28412206 )
2017
6
Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study. ( 28945804 )
2017
7
Cryptogenic Organizing Pneumonia: IL-1I^, IL-6, IL-8, and TGF- I^1 Serum Concentrations and Response to Clarithromycin Treatment. ( 26987326 )
2016
8
Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. ( 28028949 )
2016
9
Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature. ( 28081314 )
2016
10
Spontaneous resolution of cryptogenic organizing pneumonia in pediatrics: A case report. ( 27021808 )
2016
11
Azacitidine-induced cryptogenic organizing pneumonia: a case report and review of the literature. ( 26791087 )
2016
12
Erythema gyratum repens associated with cryptogenic organizing pneumonia. ( 26765132 )
2016
13
Haemoptysis as a primary manifestation of cryptogenic organizing pneumonia (COP). ( 27451594 )
2015
14
Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. ( 26508933 )
2015
15
Increased Galectin-9 Concentration and Number of CD4+Foxp3high+Cells in Bronchoalveolar Lavage Fluid of Patients with Cryptogenic Organizing Pneumonia. ( 26249221 )
2015
16
A Case of Cryptogenic Organizing Pneumonia after Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma. ( 26508948 )
2015
17
Reversed Halo Sign. A Case of Cryptogenic Organizing Pneumonia with Spontaneous Resolution. ( 26131991 )
2015
18
Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review. ( 25667636 )
2015
19
Successful Rituximab Therapy in Steroid-Resistant, Cryptogenic Organizing Pneumonia: A Case Series. ( 26045243 )
2015
20
Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. ( 25520652 )
2014
21
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. ( 24396439 )
2014
22
The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. ( 25493105 )
2014
23
Fatal case of cryptogenic organizing pneumonia associated with Everolimus. ( 25827702 )
2014
24
Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature. ( 25196175 )
2014
25
Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature. ( 25674228 )
2014
26
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. ( 24460438 )
2014
27
Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia. ( 24889556 )
2014
28
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. ( 24342432 )
2013
29
Autopsy findings of fatal cryptogenic organizing pneumonia. ( 23696931 )
2013
30
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. ( 22688586 )
2013
31
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. ( 22842502 )
2013
32
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. ( 24090908 )
2013
33
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. ( 23933758 )
2013
34
Cryptogenic organizing pneumonia with fatal respiratory failure. ( 22372175 )
2012
35
Rituximab-related cryptogenic organizing pneumonia and late onset neutropenia in a patient with non-Hodgkin lymphoma: report of two rare complications and review of the literature. ( 23033310 )
2012
36
Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man. ( 23569519 )
2012
37
Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis. ( 21675931 )
2012
38
Cryptogenic organizing pneumonia. ( 23001801 )
2012
39
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. ( 21297329 )
2011
40
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. ( 22109285 )
2011
41
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. ( 21169342 )
2011
42
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. ( 21093240 )
2011
43
Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. ( 21144722 )
2011
44
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. ( 21372463 )
2011
45
Cryptogenic organizing pneumonia mimicking malignancy in a patient with rheumatoid arthritis. ( 21885507 )
2011
46
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. ( 20594817 )
2010
47
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. ( 20668958 )
2010
48
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. ( 20696310 )
2010
49
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. ( 21088339 )
2010
50
Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review. ( 20222953 )
2010

Variations for Cryptogenic Organizing Pneumonia

Expression for Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for Cryptogenic Organizing Pneumonia

GO Terms for Cryptogenic Organizing Pneumonia

Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.56 LAMC2 MMP9 TIMP1 TNC
2 extracellular matrix GO:0031012 9.5 MMP9 TIMP1 TNC
3 extracellular space GO:0005615 9.5 CXCL8 LAMC2 MMP9 MUC1 MUC5B TIMP1
4 basement membrane GO:0005604 9.33 LAMC2 TIMP1 TNC
5 extracellular region GO:0005576 9.23 CD8A CXCL8 LAMC2 MMP9 MUC1 MUC5B

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.13 LAMC2 MMP9 TNC
2 extracellular matrix disassembly GO:0022617 8.8 LAMC2 MMP9 TIMP1

Sources for Cryptogenic Organizing Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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