COP
MCID: CRY001
MIFTS: 44

Cryptogenic Organizing Pneumonia (COP) malady

Respiratory diseases category

Summaries for Cryptogenic Organizing Pneumonia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cryptogenic organizing pneumonia (cop) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. cop often affects adults in midlife (40 to 60 years of age). no predisposing factors have been identified and the cause is often unknown. diagnosis may be made through computed tomography (ct) scan or lung biopsy. response to treatment with corticosteroids is generally favorable. last updated: 3/15/2013

MalaCards: Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to pneumonia and ulcerative colitis. An important gene associated with Cryptogenic Organizing Pneumonia is LAMC2 (laminin, gamma 2), and among its related pathways are Legionellosis and Immune response Bacterial infections in normal airways. The compounds cilomilast and n-tosyl-l-phenylalanine chloromethyl ketone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and colon, and related mouse phenotype immune system.

Disease Ontology:8 A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). a flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. frequent presence of crackling sounds (called velcro crackles) when the doctor listens with a stethoscope.

Wikipedia:63 Bronchiolitis obliterans organizing pneumonia (BOOP) is a non-infectious pneumonia; specifically, an... more...

Aliases & Classifications for Cryptogenic Organizing Pneumonia

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Sources:
48Orphanet, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 35MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
cryptogenic organizing pneumonia:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cryptogenic organizing pneumonia 8 42 10 48
bronchiolitis obliterans organizing pneumonia 48 60
idiopathic bronchiolitis obliterans with organizing pneumonia 8
idiopathic bronchiolitis obliterans organizing pneumonia 42
cryptogenic organizing pneumonitis 8
idiopathic boop 42
cop 42


External Ids:

Disease Ontology8 DOID:0050157
MESH via Orphanet35 D018549
ICD10 via Orphanet26 J84.8

Related Diseases for Cryptogenic Organizing Pneumonia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.6IL8, TNF
2ulcerative colitis31.0TNF, IL8, LAMC2
3bronchiolitis30.8IL8
4bronchiolitis obliterans30.8IL8
5adult respiratory distress syndrome30.6IL8, TNF
6interstitial lung disease30.5TNF
7sarcoidosis30.5TNF
8pulmonary fibrosis30.4IL8, TNC
9arthritis30.4TNF, IL8
10idiopathic pulmonary fibrosis30.4TNC, IL8, LAMC2
11colon cancer30.2LAMC2
12systemic lupus erythematosus10.7
13lupus erythematosus10.7
14graft versus host disease10.6
15eosinophilic pneumonia10.6
16lung cancer10.6
17bronchiolitis obliterans organizing pneumonia10.6
18wegener's granulomatosis10.5
19chronic eosinophilic pneumonia10.5
20hodgkin's lymphoma10.5
21pneumothorax10.5
22adult syndrome10.4
23breast cancer10.4
24plasmodium malariae malaria10.3
25cryoglobulinemia10.3
26cystic fibrosis10.3
27evans' syndrome10.3
28hepatitis c10.3
29primary biliary cirrhosis10.3
30common variable immunodeficiency10.3
31melioidosis10.3
32lung lymphoma10.3
33plasmodium vivax malaria10.3
34juvenile rheumatoid arthritis10.3
35acquired immunodeficiency syndrome10.3
36polymyalgia rheumatica10.3
37cryptococcosis10.3
38sclerosing cholangitis10.3
39acute leukemia10.3
40aspiration pneumonia10.3
41asthma10.3
42cholangitis10.3
43chronic lymphocytic leukemia10.3
44cystitis10.3
45hepatitis10.3
46herpes simplex10.3
47influenza10.3
48ischemia10.3
49liver disease10.3
50lymphoblastic leukemia10.3

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to cryptogenic organizing pneumonia

Clinical Features for Cryptogenic Organizing Pneumonia

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Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cryptogenic Organizing Pneumonia

Drug clinical trials:

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Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

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Genetic Tests for Cryptogenic Organizing Pneumonia

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Anatomical Context for Cryptogenic Organizing Pneumonia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

32
Lung, Breast, Colon, Kidney

Animal Models for Cryptogenic Organizing Pneumonia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7LAMC2, IL8, ING4, TOMM5, TNF

Publications for Cryptogenic Organizing Pneumonia

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50PubMed
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Articles related to Cryptogenic Organizing Pneumonia:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
2
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. (24342432)
2013
3
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. (24090908)
2013
4
Autopsy findings of fatal cryptogenic organizing pneumonia. (23696931)
2013
5
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. (23933758)
2013
6
Cryptogenic organizing pneumonia with fatal respiratory failure. (22372175)
2012
7
Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man. (23569519)
2012
8
Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis. (21675931)
2012
9
Rituximab-related cryptogenic organizing pneumonia and late onset neutropenia in a patient with non-Hodgkin lymphoma: report of two rare complications and review of the literature. (23033310)
2012
10
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. (22109285)
2011
11
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. (21169342)
2011
12
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. (21093240)
2011
13
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. (21372463)
2011
14
Cryptogenic organizing pneumonia mimicking malignancy in a patient with rheumatoid arthritis. (21885507)
2011
15
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. (20668958)
2010
16
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. (20594817)
2010
17
Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). (19639324)
2010
18
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (22958364)
2010
19
Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. (20858818)
2010
20
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. (21088339)
2010
21
Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review. (20222953)
2010
22
Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature. (19093118)
2009
23
Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. (19650943)
2009
24
An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient. (19182510)
2009
25
Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia. (19064594)
2009
26
Cryptogenic organizing pneumonia (COP), as presentation of rheumatoid arthritis. (18500458)
2008
27
Generalized pustular psoriasis and cryptogenic organizing pneumonia. (18241268)
2008
28
Cryptogenic organizing pneumonia in two patients with BehAset's disease. (17949562)
2007
29
Cryptogenic organizing pneumonia associated with Pneumocystis carinii infection and sirolimus therapy in a renal transplant patient. (16499733)
2006
30
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
31
A case of cryptogenic organizing pneumonia occurring in Crohn's disease. (16331316)
2005
32
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (16110298)
2005
33
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
34
The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia. (12006432)
2002
35
Cryptogenic organizing pneumonia. (16088692)
2001
36
A case of acute interstitial pneumonia indistinguishable from bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia: high-resolution CT findings and pathologic correlation. (9862160)
1998
37
Case 1: Cryptogenic organizing pneumonia. (9725328)
1998
38
Bronchoalveolar lavage, histological and immunohistochemical features in cryptogenic organizing pneumonia. (8909012)
1996
39
Should cryptogenic organizing pneumonia be included in the classification of pulmonary allograft rejection? (8981212)
1996
40
The diagnostic value of bronchoalveolar lavage and transbronchial lung biopsy in cryptogenic organizing pneumonia. (8980962)
1996
41
Cryptogenic organizing pneumonia in association with Sweet's syndrome. (8857328)
1996
42
Anti-Jo-1 syndrome presenting as cryptogenic organizing pneumonia. (7494922)
1995
43
Cryptogenic organizing pneumonia in the immunocompromised patient: radiologic findings and follow-up in 12 patients. (7543802)
1995
44
Cryptogenic organizing pneumonia with atypical histopathological features. (8147799)
1994
45
Cryptogenic organizing pneumonia: CT findings in 43 patients. (8109493)
1994
46
Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia. (8313672)
1993
47
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. (8313666)
1993
48
The histological diagnosis of clinically documented cases of cryptogenic organizing pneumonia: diagnostic features in transbronchial biopsies. (8314237)
1993
49
What are bronchiolitis obliterans organizing pneumonia (BOOP) and cryptogenic organizing pneumonia (COP)? (1606792)
1992
50
Obliterative bronchiolitis, cryptogenic organising pneumonitis and bronchiolitis obliterans organizing pneumonia: three names for two different conditions. (1954996)
1991

Genetic Variations for Cryptogenic Organizing Pneumonia

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Expression for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IL8
2
Immune response Bacterial infections in normal airways
9.5IL8, TNF
39.5IL8, TNF
4
Hide members
9.5IL8, TNF
59.5IL8, TNF
69.5TNF, IL8
79.5IL8, TNF
89.1LAMC2, IL8, TNF
9
Cell adhesion ECM remodeling
Hide members
9.0LAMC2, IL8, TNC
10
Hide members
8.5TNC, TNF, IL8, LAMC2

Compounds for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1cilomilast449.9IL8, TNF
2n-tosyl-l-phenylalanine chloromethyl ketone449.9IL8, TNF
3taurine chloramine449.9TNF, IL8
4gabexate mesilate449.9IL8, TNF
5toxin-1449.9TNF, IL8
6ulinastatin449.9TNF, IL8
7mip 1alpha449.9IL8, TNF
8gold sodium thiomalate449.9IL8, TNF
9il-12449.9TNF, IL8
105 aminosalicylic acid449.9TNF, IL8
11staurosporin449.9IL8, TNF
12imiquimod44 28 59 1112.9TNF, IL8
13tpck449.9TNF, IL8
14polymyxin b449.9IL8, TNF
15groalpha449.9TNF, IL8
16go 697644 5910.9TNF, IL8
17triptolide449.9TNF, IL8
18gm-csf44 2810.9TNF, IL8
19budesonide44 49 1111.8TNF, IL8
20ciglitazone44 2810.8TNF, IL8
21parthenolide44 210.8TNF, IL8
22sulfasalazine44 28 49 1112.8TNF, IL8
23lipoteichoic acid449.8TNF, IL8
248-isoprostane449.8TNF, IL8
25fluticasone propionate44 49 59 1112.8TNF, IL8
26ns 39844 5910.8IL8, TNF
27polyinosinic-polycytidylic acid449.8IL8, TNF
28etanercept44 49 1111.7TNF, IL8
29rolipram44 59 2811.7IL8, TNF
30poly(i-c)449.7IL8, TNF
31il 10449.7TNF, IL8
32diphenyleneiodonium449.6IL8, TNF
33tarc449.6TNF, IL8
34peptidoglycan44 2810.6IL8, TNF
35n-formylmethionyl-leucylphenylalanine449.5IL8, TNF
3615-deoxy-delta-12,14-prostaglandin j2449.5IL8, TNF
37ccl344 2810.4TNF, IL8
38ly294002449.2IL8, TNF, TNC
39neopterin449.2IL8, TNF
40actinomycin d449.1TNC, TNF, IL8

GO Terms for genes affiliated with Cryptogenic Organizing Pneumonia

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16Gene Ontology
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Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5LAMC2, IL8, TNF, TNC

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.5IL8, TNF
2calcium-mediated signalingGO:0197229.2TNF, IL8
3negative regulation of cell proliferationGO:0082859.0IL8, ING4, TNF
4extracellular matrix organizationGO:0301988.8LAMC2, TNF, TNC

Products for genes affiliated with Cryptogenic Organizing Pneumonia

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  • Antibodies
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Sources for Cryptogenic Organizing Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet