COP
MCID: CRY001
MIFTS: 47

Cryptogenic Organizing Pneumonia (COP) malady

Rare diseases, Respiratory diseases categories
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Summaries for Cryptogenic Organizing Pneumonia

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cryptogenic organizing pneumonia (cop) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. cop often affects adults in midlife (40 to 60 years of age). no predisposing factors have been identified and the cause is often unknown. diagnosis may be made through computed tomography (ct) scan or lung biopsy. response to treatment with corticosteroids is generally favorable. last updated: 3/15/2013

MalaCards: Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to pneumonia and ulcerative colitis. An important gene associated with Cryptogenic Organizing Pneumonia is LAMC2 (laminin, gamma 2), and among its related pathways are Non-integrin membrane-ECM interactions and Leishmaniasis. The compounds cilomilast and n-tosyl-l-phenylalanine chloromethyl ketone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and kidney, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:8 A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). a flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. frequent presence of crackling sounds (called velcro crackles) when the doctor listens with a stethoscope.

Wikipedia:65 Bronchiolitis obliterans organizing pneumonia (BOOP) is a non-infectious pneumonia; specifically, an... more...

Aliases & Classifications for Cryptogenic Organizing Pneumonia

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Sources:
49Orphanet, 62UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 36MESH via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
cryptogenic organizing pneumonia:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cryptogenic organizing pneumonia 8 43 10 49
bronchiolitis obliterans organizing pneumonia 49 62
idiopathic bronchiolitis obliterans with organizing pneumonia 8
idiopathic bronchiolitis obliterans organizing pneumonia 43
cryptogenic organizing pneumonitis 8
idiopathic boop 43
cop 43


External Ids:

Disease Ontology8 DOID:0050157
MESH via Orphanet36 D018549
ICD10 via Orphanet26 J84.8

Related Diseases for Cryptogenic Organizing Pneumonia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.7IL8, TNF
2ulcerative colitis31.0IL8, LAMC2, TNF
3bronchiolitis31.0IL8
4adult respiratory distress syndrome30.7IL8, TNF
5arthritis30.5IL8, TNF
6pulmonary fibrosis30.5TNC, IL8
7idiopathic pulmonary fibrosis30.5LAMC2, TNC, IL8
8asthma30.4IL8, TNF, TNC
9systemic lupus erythematosus10.8
10lupus erythematosus10.8
11graft versus host disease10.6
12polymyositis10.6
13bronchiolitis obliterans organizing pneumonia10.6
14bronchiolitis obliterans10.6
15chronic eosinophilic pneumonia10.5
16wegener's granulomatosis10.5
17eosinophilic pneumonia10.5
18hodgkin's lymphoma10.5
19pneumothorax10.5
20chronic graft versus host disease10.5
21hematopoietic stem cell transplantation10.5
22breast cancer10.5
23hepatitis c10.4
24evans' syndrome10.4
25cystic fibrosis10.4
26cryoglobulinemia10.4
27melioidosis10.4
28plasmodium vivax malaria10.4
29juvenile rheumatoid arthritis10.4
30acquired immunodeficiency syndrome10.4
31polymyalgia rheumatica10.4
32primary biliary cirrhosis10.4
33common variable immunodeficiency10.4
34cryptococcosis10.4
35sclerosing cholangitis10.4
36cholangitis10.4
37chronic lymphocytic leukemia10.4
38cystitis10.4
39hepatitis10.4
40herpes simplex10.4
41influenza10.4
42ischemia10.4
43lung cancer10.4
44lymphoblastic leukemia10.4
45malaria10.4
46myopathy10.4
47panniculitis10.4
48sarcoidosis10.4
49scleroderma10.4
50thyroiditis10.4

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to cryptogenic organizing pneumonia

Symptoms for Cryptogenic Organizing Pneumonia

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Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cryptogenic Organizing Pneumonia

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

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Anatomical Context for Cryptogenic Organizing Pneumonia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

33
Lung, Breast, Kidney, Colon

Animal Models for Cryptogenic Organizing Pneumonia or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7TOMM5, LAMC2, TNF
2MP:00053877.8IL8, TOMM5, LAMC2, TNF

Publications for Cryptogenic Organizing Pneumonia

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52PubMed
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Articles related to Cryptogenic Organizing Pneumonia:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. (24396439)
2014
2
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
3
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. (24342432)
2013
4
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. (24090908)
2013
5
Autopsy findings of fatal cryptogenic organizing pneumonia. (23696931)
2013
6
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. (22688586)
2013
7
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. (23933758)
2013
8
Cryptogenic organizing pneumonia with fatal respiratory failure. (22372175)
2012
9
Cryptogenic organizing pneumonia. (23001801)
2012
10
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. (22109285)
2011
11
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. (21169342)
2011
12
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. (21093240)
2011
13
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. (21297329)
2011
14
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. (21372463)
2011
15
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. (20668958)
2010
16
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. (20594817)
2010
17
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. (20696310)
2010
18
Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). (19639324)
2010
19
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (22958364)
2010
20
Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. (20858818)
2010
21
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. (21088339)
2010
22
Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature. (19093118)
2009
23
Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. (19650943)
2009
24
An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient. (19182510)
2009
25
Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia. (19064594)
2009
26
Cryptogenic organizing pneumonia: clinical profile in a series of 34 admitted patients in a hospital in India. (18702383)
2008
27
Cryptogenic organizing pneumonia (COP), as presentation of rheumatoid arthritis. (18500458)
2008
28
Cryptogenic organizing pneumonia in two patients with BehAset's disease. (17949562)
2007
29
Cryptogenic organizing pneumonia associated with Pneumocystis carinii infection and sirolimus therapy in a renal transplant patient. (16499733)
2006
30
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
31
A case of cryptogenic organizing pneumonia occurring in Crohn's disease. (16331316)
2005
32
Cryptogenic organizing pneumonia: variety of radiologic findings. (16190479)
2005
33
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (16110298)
2005
34
Cryptogenic organizing pneumonia. (15564018)
2004
35
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
36
The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia. (12006432)
2002
37
Cryptogenic organizing pneumonia. (16088692)
2001
38
Cryptogenic organizing pneumonia is an important cause of graft dysfunction and should be included in the classification of pulmonary allograft rejection. (9513862)
1998
39
A case of acute interstitial pneumonia indistinguishable from bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia: high-resolution CT findings and pathologic correlation. (9862160)
1998
40
Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. (9310948)
1997
41
Bronchoalveolar lavage, histological and immunohistochemical features in cryptogenic organizing pneumonia. (8909012)
1996
42
Neutrophil chemotactic activity in cryptogenic organizing pneumonia and the response to erythromycin. (8942140)
1996
43
Should cryptogenic organizing pneumonia be included in the classification of pulmonary allograft rejection? (8981212)
1996
44
Anti-Jo-1 syndrome presenting as cryptogenic organizing pneumonia. (7494922)
1995
45
Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. (8292374)
1994
46
Cryptogenic organizing pneumonia with atypical histopathological features. (8147799)
1994
47
Cryptogenic organizing pneumonia: CT findings in 43 patients. (8109493)
1994
48
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. (8313666)
1993
49
What are bronchiolitis obliterans organizing pneumonia (BOOP) and cryptogenic organizing pneumonia (COP)? (1606792)
1992
50
The radiology and terminology of cryptogenic organizing pneumonia. (1393393)
1992

Variations for Cryptogenic Organizing Pneumonia

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Expression for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters, 54R&D Systems, 12EMD Millipore
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Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events38
9.5LAMC2, TNC
2
Show member pathways
9.2LAMC2, TNF
3
Show member pathways
Immune response MIF in innate immunity response60
9.0TNF, IL8
49.0TNF, IL8
5
Show member pathways
9.0TNF, IL8
69.0TNF, IL8
7
Show member pathways
9.0IL8, TNF
89.0IL8, TNF
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0IL8, TNF
109.0IL8, TNF
119.0TNF, IL8
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0IL8, TNF
139.0IL8, TNF
149.0TNF, IL8
159.0IL8, TNF
169.0IL8, TNF
179.0TNF, IL8
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.0IL8, TNF
199.0IL8, TNF
20
Show member pathways
8.9TNC, LAMC2, IL8
21
Show member pathways
8.9IL8, LAMC2, TNC
228.6IL8, LAMC2, TNF
23
Show member pathways
8.1TNC, TNF, LAMC2, IL8

Compounds for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB, 24HMDB
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Compounds related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cilomilast459.5TNF, IL8
2n-tosyl-l-phenylalanine chloromethyl ketone459.5IL8, TNF
3taurine chloramine459.5TNF, IL8
4gabexate mesilate459.5IL8, TNF
5ulinastatin459.5TNF, IL8
6toxin-1459.5TNF, IL8
7mip 1alpha459.5IL8, TNF
8gold sodium thiomalate459.5TNF, IL8
9aebsf459.5TNF, IL8
10il-12459.5IL8, TNF
115 aminosalicylic acid459.5TNF, IL8
12staurosporin459.5IL8, TNF
13tpck459.5IL8, TNF
14imiquimod45 61 29 1112.4IL8, TNF
15polymyxin b459.4TNF, IL8
16groalpha459.4IL8, TNF
17go 697645 6110.4TNF, IL8
18triptolide459.4IL8, TNF
19gm-csf45 2910.4IL8, TNF
20budesonide45 51 1111.4TNF, IL8
21parthenolide45 310.4TNF, IL8
22ciglitazone45 2910.4TNF, IL8
23sulfasalazine29 45 51 1112.4IL8, TNF
24lipoteichoic acid459.4TNF, IL8
258-isoprostane459.4TNF, IL8
26fluticasone propionate45 51 61 1112.4IL8, TNF
27ns 39845 6110.4IL8, TNF
28polyinosinic-polycytidylic acid459.4TNF, IL8
29rolipram45 61 2911.4TNF, IL8
30etanercept45 51 1111.4TNF, IL8
31poly(i-c)459.4IL8, TNF
32il 10459.3TNF, IL8
33diphenyleneiodonium459.3IL8, TNF
34tarc459.3IL8, TNF
35peptidoglycan45 2910.3TNF, IL8
36n-formylmethionyl-leucylphenylalanine459.3TNF, IL8
37ccl345 2910.3TNF, IL8
38pentoxifylline45 1110.3IL8, TNF
39neopterin459.2TNF, IL8
4015-deoxy-delta-12,14-prostaglandin j2459.2TNF, IL8
41pdtc459.1IL8, TNF
42hydrocortisone45 3 61 1112.0IL8, TNF
43leukotriene b445 61 2410.9TNF, IL8
44ly294002458.9TNC, IL8, TNF
45actinomycin d458.9IL8, TNC, TNF
46cycloheximide458.8TNC, TNF, IL8
47sp 60012545 619.7TNF, IL8
48h2o2458.7TNC, IL8, TNF
49dexamethasone45 51 29 1111.6TNC, IL8, TNF
50vegf458.5TNF, IL8, TNC

GO Terms for genes affiliated with Cryptogenic Organizing Pneumonia

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16Gene Ontology
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Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1IL8, LAMC2, TNF, TNC
2extracellular spaceGO:0056157.8IL8, LAMC2, TNF, TNC

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to mechanical stimulusGO:0096129.1TNF, TNC
2embryonic digestive tract developmentGO:0485669.0IL8, TNF
3calcium-mediated signalingGO:0197228.7IL8, TNF
4extracellular matrix organizationGO:0301988.6LAMC2, TNF, TNC

Products for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources for Cryptogenic Organizing Pneumonia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet