COP
MCID: CRY001
MIFTS: 48

Cryptogenic Organizing Pneumonia (COP) malady

Rare diseases, Respiratory diseases categories
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Summaries for Cryptogenic Organizing Pneumonia

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NIH Rare Diseases:42 Cryptogenic organizing pneumonia (cop) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. cop often affects adults in midlife (40 to 60 years of age). no predisposing factors have been identified and the cause is often unknown. diagnosis may be made through computed tomography (ct) scan or lung biopsy. response to treatment with corticosteroids is generally favorable. last updated: 3/15/2013

MalaCards based summary: Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to pneumonia and bronchiolitis. An important gene associated with Cryptogenic Organizing Pneumonia is LAMC2 (laminin, gamma 2), and among its related pathways are Non-integrin membrane-ECM interactions and Leishmaniasis. The compounds cilomilast and n-tosyl-l-phenylalanine chloromethyl ketone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and colon, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:8 A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). a flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. frequent presence of crackling sounds (called velcro crackles) when the doctor listens with a stethoscope.

Wikipedia:65 Bronchiolitis obliterans organizing pneumonia (BOOP) is a non-infectious pneumonia; specifically, an... more...

Aliases & Classifications for Cryptogenic Organizing Pneumonia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 35MESH via Orphanet
See all sources

Cryptogenic Organizing Pneumonia, Aliases & Descriptions:

Name: Cryptogenic Organizing Pneumonia 8 42 10 48
Bronchiolitis Obliterans Organizing Pneumonia 48 62
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 8
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 42
 
Cryptogenic Organizing Pneumonitis 8
Idiopathic Boop 42
Cop 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
cryptogenic organizing pneumonia:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:0050157
ICD10 via Orphanet26 J84.8
MESH via Orphanet35 D018549

Related Diseases for Cryptogenic Organizing Pneumonia

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Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.8IL8, TNF
2bronchiolitis31.3IL8
3colitis31.0IL8, TNF
4ulcerative colitis30.8IL8, LAMC2, TNF
5adult respiratory distress syndrome30.7IL8, TNF
6arthritis30.6IL8, TNF
7pulmonary fibrosis30.4TNC, IL8
8idiopathic pulmonary fibrosis30.2LAMC2, TNC, IL8
9asthma30.1IL8, TNF, TNC
10systemic lupus erythematosus10.8
11lupus erythematosus10.8
12bronchiolitis obliterans organizing pneumonia10.6
13graft versus host disease10.6
14polymyositis10.6
15bronchiolitis obliterans10.6
16hematopoietic stem cell transplantation10.5
17hodgkin's lymphoma10.5
18wegener's granulomatosis10.5
19pneumothorax10.5
20chronic graft versus host disease10.5
21breast cancer10.5
22chronic eosinophilic pneumonia10.4
23eosinophilic pneumonia10.4
24crohn's disease10.4
25rheumatoid arthritis10.4
26acute lymphoblastic leukemia10.4
27chronic lymphocytic leukemia10.4
28common variable immunodeficiency10.4
29cystic fibrosis10.4
30hepatitis10.4
31malaria10.4
32primary biliary cirrhosis10.4
33cryoglobulinemia10.4
34sclerosing cholangitis10.4
35hepatitis c10.4
36plasmodium vivax malaria10.4
37juvenile rheumatoid arthritis10.4
38acquired immunodeficiency syndrome10.4
39polymyalgia rheumatica10.4
40melioidosis10.4
41cryptococcosis10.4
42evans' syndrome10.4
43cholangitis10.4
44cystitis10.4
45herpes simplex10.4
46influenza10.4
47ischemia10.4
48lung cancer10.4
49lymphoblastic leukemia10.4
50myopathy10.4

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to cryptogenic organizing pneumonia

Symptoms for Cryptogenic Organizing Pneumonia

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Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

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Drug clinical trials:

Search ClinicalTrials for Cryptogenic Organizing Pneumonia

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

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Anatomical Context for Cryptogenic Organizing Pneumonia

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MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

32
Lung, Breast, Colon, Kidney, Neutrophil

Animal Models for Cryptogenic Organizing Pneumonia or affiliated genes

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MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7TOMM5, LAMC2, TNF
2MP:00053877.8IL8, TOMM5, LAMC2, TNF

Publications for Cryptogenic Organizing Pneumonia

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Articles related to Cryptogenic Organizing Pneumonia:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature. (25196175)
2014
2
Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia. (24889556)
2014
3
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. (24396439)
2014
4
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. (24460438)
2014
5
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
6
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. (24342432)
2013
7
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. (24090908)
2013
8
Autopsy findings of fatal cryptogenic organizing pneumonia. (23696931)
2013
9
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. (22688586)
2013
10
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. (23933758)
2013
11
Cryptogenic organizing pneumonia with fatal respiratory failure. (22372175)
2012
12
Cryptogenic organizing pneumonia. (23001801)
2012
13
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. (22109285)
2011
14
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. (21169342)
2011
15
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. (21093240)
2011
16
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. (21297329)
2011
17
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. (21372463)
2011
18
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. (20668958)
2010
19
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. (20594817)
2010
20
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. (20696310)
2010
21
Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). (19639324)
2010
22
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (22958364)
2010
23
Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. (20858818)
2010
24
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. (21088339)
2010
25
Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature. (19093118)
2009
26
Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. (19650943)
2009
27
An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient. (19182510)
2009
28
Cryptogenic organizing pneumonia: clinical profile in a series of 34 admitted patients in a hospital in India. (18702383)
2008
29
Cryptogenic organizing pneumonia (COP), as presentation of rheumatoid arthritis. (18500458)
2008
30
Cryptogenic organizing pneumonia in two patients with BehAset's disease. (17949562)
2007
31
Cryptogenic organizing pneumonia associated with Pneumocystis carinii infection and sirolimus therapy in a renal transplant patient. (16499733)
2006
32
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
33
A case of cryptogenic organizing pneumonia occurring in Crohn's disease. (16331316)
2005
34
Cryptogenic organizing pneumonia: variety of radiologic findings. (16190479)
2005
35
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (16110298)
2005
36
Cryptogenic organizing pneumonia. (15564018)
2004
37
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
38
The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia. (12006432)
2002
39
Cryptogenic organizing pneumonia. (16088692)
2001
40
Cryptogenic organizing pneumonia is an important cause of graft dysfunction and should be included in the classification of pulmonary allograft rejection. (9513862)
1998
41
A case of acute interstitial pneumonia indistinguishable from bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia: high-resolution CT findings and pathologic correlation. (9862160)
1998
42
Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. (9310948)
1997
43
Bronchoalveolar lavage, histological and immunohistochemical features in cryptogenic organizing pneumonia. (8909012)
1996
44
Neutrophil chemotactic activity in cryptogenic organizing pneumonia and the response to erythromycin. (8942140)
1996
45
Anti-Jo-1 syndrome presenting as cryptogenic organizing pneumonia. (7494922)
1995
46
Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. (8292374)
1994
47
Cryptogenic organizing pneumonia with atypical histopathological features. (8147799)
1994
48
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. (8313666)
1993
49
What are bronchiolitis obliterans organizing pneumonia (BOOP) and cryptogenic organizing pneumonia (COP)? (1606792)
1992
50
The radiology and terminology of cryptogenic organizing pneumonia. (1393393)
1992

Variations for Cryptogenic Organizing Pneumonia

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Expression for genes affiliated with Cryptogenic Organizing Pneumonia

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Expression patterns in normal tissues for genes affiliated with Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for genes affiliated with Cryptogenic Organizing Pneumonia

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Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events37
9.5TNC, LAMC2
2
Show member pathways
9.2LAMC2, TNF
3
Show member pathways
Immune response MIF in innate immunity response60
9.0IL8, TNF
4
Show member pathways
9.0IL8, TNF
59.0TNF, IL8
69.0IL8, TNF
7
Show member pathways
9.0IL8, TNF
89.0TNF, IL8
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0TNF, IL8
109.0TNF, IL8
119.0TNF, IL8
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0IL8, TNF
139.0TNF, IL8
149.0IL8, TNF
159.0IL8, TNF
169.0IL8, TNF
179.0TNF, IL8
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.0TNF, IL8
199.0IL8, TNF
20
Show member pathways
8.9TNC, LAMC2, IL8
21
Show member pathways
8.9TNC, LAMC2, IL8
228.6IL8, LAMC2, TNF
23
Show member pathways
8.1TNC, TNF, LAMC2, IL8

Compounds for genes affiliated with Cryptogenic Organizing Pneumonia

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Compounds related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cilomilast449.5IL8, TNF
2n-tosyl-l-phenylalanine chloromethyl ketone449.5IL8, TNF
3taurine chloramine449.5IL8, TNF
4gabexate mesilate449.5TNF, IL8
5toxin-1449.5IL8, TNF
6ulinastatin449.5IL8, TNF
7mip 1alpha449.5TNF, IL8
8gold sodium thiomalate449.5IL8, TNF
9aebsf449.5IL8, TNF
105 aminosalicylic acid449.5TNF, IL8
11il-12449.5TNF, IL8
12staurosporin449.5IL8, TNF
13imiquimod44 61 28 1112.5TNF, IL8
14tpck449.4TNF, IL8
15polymyxin b449.4IL8, TNF
16groalpha449.4IL8, TNF
17gm-csf44 2810.4TNF, IL8
18triptolide449.4TNF, IL8
19go 697644 6110.4TNF, IL8
20parthenolide44 210.4TNF, IL8
21ciglitazone44 2810.4TNF, IL8
22budesonide44 50 1111.4TNF, IL8
23sulfasalazine28 44 50 1112.4TNF, IL8
24lipoteichoic acid449.4TNF, IL8
258-isoprostane449.4IL8, TNF
26fluticasone propionate44 50 61 1112.4IL8, TNF
27ns 39844 6110.4TNF, IL8
28polyinosinic-polycytidylic acid449.4IL8, TNF
29rolipram44 61 2811.4IL8, TNF
30etanercept44 50 1111.4IL8, TNF
31poly(i-c)449.4TNF, IL8
32il 10449.3IL8, TNF
33diphenyleneiodonium449.3IL8, TNF
34tarc449.3TNF, IL8
35peptidoglycan44 2810.3IL8, TNF
36n-formylmethionyl-leucylphenylalanine449.3TNF, IL8
37pentoxifylline44 1110.3IL8, TNF
38ccl344 2810.3IL8, TNF
39neopterin449.2IL8, TNF
4015-deoxy-delta-12,14-prostaglandin j2449.2IL8, TNF
41pdtc449.1TNF, IL8
42hydrocortisone44 2 61 1112.0IL8, TNF
43leukotriene b444 61 2410.9IL8, TNF
44ly294002448.9IL8, TNF, TNC
45actinomycin d448.9TNC, TNF, IL8
46cycloheximide448.8TNC, TNF, IL8
47sp 60012544 619.7IL8, TNF
48h2o2448.7TNC, TNF, IL8
49dexamethasone44 50 28 1111.6IL8, TNF, TNC
50vegf448.5TNC, TNF, IL8

GO Terms for genes affiliated with Cryptogenic Organizing Pneumonia

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Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1IL8, LAMC2, TNF, TNC
2extracellular spaceGO:0056157.8IL8, LAMC2, TNF, TNC

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to mechanical stimulusGO:0096129.1TNF, TNC
2embryonic digestive tract developmentGO:0485669.0IL8, TNF
3calcium-mediated signalingGO:0197228.7IL8, TNF
4extracellular matrix organizationGO:0301988.6LAMC2, TNF, TNC

Products for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources for Cryptogenic Organizing Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet