MCID: CRY001
MIFTS: 40

Cryptogenic Organizing Pneumonia malady

Rare diseases, Respiratory diseases categories

Summaries for Cryptogenic Organizing Pneumonia

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NIH Rare Diseases:41 Cryptogenic organizing pneumonia (cop) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. cop often affects adults in midlife (40 to 60 years of age). no predisposing factors have been identified and the cause is often unknown. diagnosis may be made through computed tomography (ct) scan or lung biopsy. response to treatment with corticosteroids is generally favorable. last updated: 3/15/2013

MalaCards based summary: Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to pneumonia and bronchiolitis. An important gene associated with Cryptogenic Organizing Pneumonia is LAMC2 (laminin, gamma 2), and among its related pathways are Non-integrin membrane-ECM interactions and Leishmaniasis. The compounds cilomilast and n-tosyl-l-phenylalanine chloromethyl ketone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and colon, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:9 An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). a flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. frequent presence of crackling sounds (called velcro crackles) when the doctor listens with a stethoscope.

Aliases & Classifications for Cryptogenic Organizing Pneumonia

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 38NCIt, 26ICD10 via Orphanet, 34MESH via Orphanet
See all sources

Cryptogenic Organizing Pneumonia, Aliases & Descriptions:

Name: Cryptogenic Organizing Pneumonia 9 41 11 47
Bronchiolitis Obliterans Organizing Pneumonia 41 47 60
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 9
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 41
 
Cryptogenic Organizing Pneumonitis 9
Idiopathic Boop 41
Cop 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

47
cryptogenic organizing pneumonia:
Inheritance: Not applicable; Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:0050157
NCIt38 C62586
Orphanet47 1302
ICD10 via Orphanet26 J84.8
MESH via Orphanet34 D018549

Related Diseases for Cryptogenic Organizing Pneumonia

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Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.8IL8, TNF
2bronchiolitis31.2IL8
3colitis30.9TNF, IL8
4ulcerative colitis30.8TNF, LAMC2, IL8
5acute respiratory distress syndrome30.8TNF, IL8
6arthritis30.6IL8, TNF
7pulmonary fibrosis30.4IL8, TNC
8asthma30.1IL8, TNF, TNC
9systemic lupus erythematosus10.8
10lupus erythematosus10.8
11polymyositis10.6
12bronchiolitis obliterans organizing pneumonia10.6
13bronchiolitis obliterans10.6
14lung cancer10.5
15hematopoietic stem cell transplantation10.5
16chronic eosinophilic pneumonia10.5
17eosinophilic pneumonia10.5
18pneumothorax10.5
19chronic graft versus host disease10.5
20adult respiratory distress syndrome10.5
21cystic fibrosis10.4
22immunodeficiency 1310.4
23malaria10.4
24chronic lymphocytic leukemia10.4
25common variable immunodeficiency10.4
26hepatitis10.4
27primary biliary cirrhosis10.4
28hepatitis c10.4
29evans' syndrome10.4
30cryoglobulinemia10.4
31melioidosis10.4
32plasmodium vivax malaria10.4
33juvenile rheumatoid arthritis10.4
34acquired immunodeficiency syndrome10.4
35polymyalgia rheumatica10.4
36sclerosing cholangitis10.4
37cryptococcosis10.4
38cholangitis10.4
39cystitis10.4
40herpes simplex10.4
41influenza10.4
42ischemia10.4
43lymphoblastic leukemia10.4
44myopathy10.4
45panniculitis10.4
46scleroderma10.4
47thyroiditis10.4
48mycobacterium kansasii10.4
49spontaneous pneumothorax10.4
50cytomegalovirus infection10.4

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to cryptogenic organizing pneumonia

Symptoms for Cryptogenic Organizing Pneumonia

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Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

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Drug clinical trials:

Search ClinicalTrials for Cryptogenic Organizing Pneumonia

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

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Anatomical Context for Cryptogenic Organizing Pneumonia

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MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

31
Lung, Breast, Colon, Kidney, Neutrophil

Animal Models for Cryptogenic Organizing Pneumonia or affiliated genes

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MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7TOMM5, LAMC2, TNF
2MP:00053877.8IL8, TOMM5, LAMC2, TNF

Publications for Cryptogenic Organizing Pneumonia

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Articles related to Cryptogenic Organizing Pneumonia:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review. (25667636)
2015
2
Fatal case of cryptogenic organizing pneumonia associated with Everolimus. (25827702)
2014
3
The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. (25493105)
2014
4
Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature. (25196175)
2014
5
Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia. (24889556)
2014
6
Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature. (25674228)
2014
7
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. (24396439)
2014
8
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. (24460438)
2014
9
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. (22842502)
2013
10
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. (24342432)
2013
11
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. (24090908)
2013
12
Autopsy findings of fatal cryptogenic organizing pneumonia. (23696931)
2013
13
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. (22688586)
2013
14
Cryptogenic organizing pneumonia with fatal respiratory failure. (22372175)
2012
15
Cryptogenic organizing pneumonia. (23001801)
2012
16
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. (22109285)
2011
17
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. (21169342)
2011
18
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. (21093240)
2011
19
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. (21297329)
2011
20
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. (21372463)
2011
21
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. (20668958)
2010
22
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. (20594817)
2010
23
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. (20696310)
2010
24
Signal recognition particle (SRP) positive myositis in a patient with cryptogenic organizing pneumonia (COP). (19639324)
2010
25
Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. (20858818)
2010
26
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. (21088339)
2010
27
Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature. (19093118)
2009
28
Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. (19650943)
2009
29
An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient. (19182510)
2009
30
Cryptogenic organizing pneumonia: clinical profile in a series of 34 admitted patients in a hospital in India. (18702383)
2008
31
Cryptogenic organizing pneumonia (COP), as presentation of rheumatoid arthritis. (18500458)
2008
32
Cryptogenic organizing pneumonia in two patients with BehAset's disease. (17949562)
2007
33
Cryptogenic organizing pneumonia associated with Pneumocystis carinii infection and sirolimus therapy in a renal transplant patient. (16499733)
2006
34
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
35
A case of cryptogenic organizing pneumonia occurring in Crohn's disease. (16331316)
2005
36
Cryptogenic organizing pneumonia: variety of radiologic findings. (16190479)
2005
37
Cryptogenic organizing pneumonia. (15564018)
2004
38
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
39
The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia. (12006432)
2002
40
Cryptogenic organizing pneumonia. (16088692)
2001
41
Cryptogenic organizing pneumonia is an important cause of graft dysfunction and should be included in the classification of pulmonary allograft rejection. (9513862)
1998
42
Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. (9310948)
1997
43
Bronchoalveolar lavage, histological and immunohistochemical features in cryptogenic organizing pneumonia. (8909012)
1996
44
Neutrophil chemotactic activity in cryptogenic organizing pneumonia and the response to erythromycin. (8942140)
1996
45
Anti-Jo-1 syndrome presenting as cryptogenic organizing pneumonia. (7494922)
1995
46
Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. (8292374)
1994
47
Cryptogenic organizing pneumonia with atypical histopathological features. (8147799)
1994
48
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. (8313666)
1993
49
What are bronchiolitis obliterans organizing pneumonia (BOOP) and cryptogenic organizing pneumonia (COP)? (1606792)
1992
50
The radiology and terminology of cryptogenic organizing pneumonia. (1393393)
1992

Variations for Cryptogenic Organizing Pneumonia

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Expression for genes affiliated with Cryptogenic Organizing Pneumonia

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Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for genes affiliated with Cryptogenic Organizing Pneumonia

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Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events36
9.5LAMC2, TNC
2
Show member pathways
9.2LAMC2, TNF
3
Show member pathways
Immune response MIF in innate immunity response58
9.0TNF, IL8
49.0TNF, IL8
5
Show member pathways
9.0TNF, IL8
69.0TNF, IL8
7
Show member pathways
9.0IL8, TNF
89.0IL8, TNF
9
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0IL8, TNF
109.0IL8, TNF
119.0TNF, IL8
12
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.0IL8, TNF
139.0IL8, TNF
149.0TNF, IL8
159.0IL8, TNF
169.0IL8, TNF
179.0TNF, IL8
18
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.0IL8, TNF
199.0IL8, TNF
20
Show member pathways
8.9TNC, LAMC2, IL8
21
Show member pathways
Metalloproteases in connective tissue degradation
8.9IL8, LAMC2, TNC
228.6IL8, LAMC2, TNF
23
Show member pathways
8.1TNC, TNF, LAMC2, IL8

Compounds for genes affiliated with Cryptogenic Organizing Pneumonia

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Compounds related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1cilomilast439.5IL8, TNF
2n-tosyl-l-phenylalanine chloromethyl ketone439.5IL8, TNF
3taurine chloramine439.5IL8, TNF
4gabexate mesilate439.5TNF, IL8
5toxin-1439.5IL8, TNF
6ulinastatin439.5IL8, TNF
7mip 1alpha439.5TNF, IL8
8gold sodium thiomalate439.5IL8, TNF
9aebsf439.5IL8, TNF
105 aminosalicylic acid439.5TNF, IL8
11il-12439.5TNF, IL8
12staurosporin439.5IL8, TNF
13imiquimod43 59 28 1212.5TNF, IL8
14tpck439.4TNF, IL8
15polymyxin b439.4IL8, TNF
16groalpha439.4IL8, TNF
17gm-csf43 2810.4TNF, IL8
18triptolide439.4TNF, IL8
19go 697643 5910.4TNF, IL8
20parthenolide43 210.4TNF, IL8
21ciglitazone43 2810.4TNF, IL8
22budesonide43 49 1211.4TNF, IL8
23sulfasalazine28 43 49 1212.4TNF, IL8
24lipoteichoic acid439.4TNF, IL8
258-isoprostane439.4IL8, TNF
26fluticasone propionate43 49 59 1212.4IL8, TNF
27ns 39843 5910.4TNF, IL8
28polyinosinic-polycytidylic acid439.4IL8, TNF
29rolipram43 59 2811.4IL8, TNF
30etanercept43 49 1211.4IL8, TNF
31poly(i-c)439.4TNF, IL8
32il 10439.3IL8, TNF
33diphenyleneiodonium439.3IL8, TNF
34tarc439.3TNF, IL8
35peptidoglycan43 2810.3IL8, TNF
36n-formylmethionyl-leucylphenylalanine439.3TNF, IL8
37pentoxifylline43 1210.3IL8, TNF
38ccl343 2810.3IL8, TNF
39neopterin439.2IL8, TNF
4015-deoxy-delta-12,14-prostaglandin j2439.2IL8, TNF
41pdtc439.1TNF, IL8
42hydrocortisone43 2 59 1212.0IL8, TNF
43leukotriene b443 59 2410.9IL8, TNF
44ly294002438.9IL8, TNF, TNC
45actinomycin d438.9TNC, TNF, IL8
46cycloheximide438.8TNC, TNF, IL8
47sp 60012543 599.7IL8, TNF
48h2o2438.7TNC, TNF, IL8
49dexamethasone43 49 28 1211.6IL8, TNF, TNC
50vegf438.5TNC, TNF, IL8

GO Terms for genes affiliated with Cryptogenic Organizing Pneumonia

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Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.1IL8, LAMC2, TNF, TNC
2extracellular spaceGO:00056157.8IL8, LAMC2, TNF, TNC

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to mechanical stimulusGO:00096129.1TNF, TNC
2embryonic digestive tract developmentGO:00485669.0IL8, TNF
3calcium-mediated signalingGO:00197228.7IL8, TNF
4extracellular matrix organizationGO:00301988.6LAMC2, TNF, TNC

Products for genes affiliated with Cryptogenic Organizing Pneumonia

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Sources for Cryptogenic Organizing Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet