MCID: CRY001
MIFTS: 45

Cryptogenic Organizing Pneumonia

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Cryptogenic Organizing Pneumonia

MalaCards integrated aliases for Cryptogenic Organizing Pneumonia:

Name: Cryptogenic Organizing Pneumonia 12 49 55 41 14
Bronchiolitis Obliterans Organizing Pneumonia 12 49 55 69
Constrictive Bronchiolitis 49 69
Boop 12 49
Cop 49 55
Idiopathic Bronchiolitis Obliterans with Organizing Pneumonia 12
Idiopathic Bronchiolitis Obliterans Organizing Pneumonia 49
Cryptogenic Organizing Pneumonitis 12
Organizing Pneumonia 49
Organized Pneumonia 69
Idiopathic Boop 49

Characteristics:

Orphanet epidemiological data:

55
cryptogenic organizing pneumonia
Inheritance: Not applicable; Prevalence: 1-9/100000 (Iceland); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:0050157
ICD10 32 J84.116
ICD9CM 34 516.36
MeSH 41 D018549
NCIt 46 C62586
SNOMED-CT 64 129458007
Orphanet 55 ORPHA1302
MESH via Orphanet 42 D018549
UMLS via Orphanet 70 C0242770
ICD10 via Orphanet 33 J84.1

Summaries for Cryptogenic Organizing Pneumonia

NIH Rare Diseases : 49 Bronchiolitis obliterans organizing pneumonia (BOOP) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). BOOP typically develops in individuals between 40-60 years old; however the disorder may affect individuals of any age. The signs and symptoms of BOOP vary but often include shortness of breath, a dry cough, and fever. BOOP can be caused by viral infections, various drugs, and other medical conditions. If the cause is known, the condition is called secondary BOOP. In many cases, the underlying cause of BOOP is unknown. These cases are called idiopathic BOOP or cryptogenic organizing pneumonia. Treatment often includes corticosteroid medications. Last updated: 2/16/2016

MalaCards based summary : Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to pneumonia and bronchiolitis obliterans. An important gene associated with Cryptogenic Organizing Pneumonia is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Degradation of the extracellular matrix and IL-17 Family Signaling Pathways. The drugs Azithromycin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and neutrophil.

Disease Ontology : 12 An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

Wikipedia : 72 Cryptogenic organizing pneumonia (COP) also known as bronchiolitis obliterans organizing pneumonia... more...

Related Diseases for Cryptogenic Organizing Pneumonia

Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 pneumonia 31.1 CXCL8 MUC5B PIK3C2A
2 bronchiolitis obliterans 30.5 CXCL8 MMP9 TIMP1
3 pulmonary fibrosis 29.9 MMP9 MUC5B TIMP1
4 pulmonary fibrosis, idiopathic 28.9 CXCL8 MMP9 MUC1 MUC5B TIMP1
5 idiopathic interstitial pneumonia 11.2
6 vibratory urticaria 10.4 CXCL8 MMP9
7 acute transverse myelitis 10.4 CXCL8 MMP9
8 chronic venous leg ulcers 10.4 MMP9 TIMP1
9 transverse myelitis 10.4 CXCL8 MMP9
10 periodontosis 10.4 CXCL8 MMP9
11 mycetoma 10.4 CXCL8 MMP9
12 squamous cell carcinoma of the hypopharynx 10.4 MMP9 TIMP1
13 tuberculous meningitis 10.4 CXCL8 MMP9
14 conjunctival nevus 10.4 MMP9 TIMP1
15 microcystic meningioma 10.4 MMP9 TIMP1
16 sorsby fundus dystrophy 10.4 MMP9 TIMP1
17 nasal cavity squamous cell carcinoma 10.4 MMP9 TIMP1
18 light chain deposition disease 10.3 MMP9 TNC
19 pleural tuberculosis 10.3 CXCL8 TIMP1
20 bronchopulmonary dysplasia 10.3 CXCL8 TIMP1
21 central nervous system tuberculosis 10.3 MMP9 TIMP1
22 bullous keratopathy 10.3 CXCL8 TNC
23 toxic myocarditis 10.3 CXCL8 PIK3C2A
24 status asthmaticus 10.3 CXCL8 PIK3C2A
25 inguinal hernia 10.3 MMP9 TIMP1
26 hydronephrosis 10.3 MMP9 TIMP1
27 chorioamnionitis 10.2 CXCL8 MMP9
28 pulmonary emphysema 10.2 MMP9 TIMP1
29 desquamative interstitial pneumonia 10.2 MUC5B TNC
30 carotid stenosis 10.2 CXCL8 MMP9
31 middle ear disease 10.2 CXCL8 MUC5B
32 carotid artery disease 10.2 MMP9 TIMP1
33 microvascular complications of diabetes 1 10.2 CXCL8 MMP9
34 bronchiolitis 10.2
35 leptospirosis 10.2 CXCL8 PIK3C2A
36 nose disease 10.2 CXCL8 MUC5B
37 spinal cord injury 10.2 CXCL8 MMP9
38 upper respiratory tract disease 10.2 CXCL8 MUC5B
39 lung giant cell carcinoma 10.2 CXCL8 MMP9 TIMP1
40 appendicitis 10.2 CXCL8 MMP9 TIMP1
41 periodontitis 10.2 CXCL8 MMP9 TIMP1
42 periodontal disease 10.2 CXCL8 MMP9 TIMP1
43 fasciitis 10.1 CXCL8 MUC1
44 bile duct mucoepidermoid carcinoma 10.1 MUC1 MUC5B
45 chronic ethmoiditis 10.1 MUC1 MUC5B
46 pneumothorax 10.1 MMP9 MUC1
47 bacterial meningitis 10.0 CXCL8 MMP9 PIK3C2A
48 respiratory system disease 10.0 CXCL8 MMP9 MUC5B
49 ethmoid sinusitis 10.0 MUC1 MUC5B
50 colloid carcinoma of the pancreas 10.0 MUC1 MUC5B

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to Cryptogenic Organizing Pneumonia

Symptoms & Phenotypes for Cryptogenic Organizing Pneumonia

Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

Drugs for Cryptogenic Organizing Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 2 83905-01-5 53477736 447043 55185
2
Budesonide Approved Phase 2 51333-22-3 5281004 63006
3
Montelukast Approved Phase 2 158966-92-8 5281040
4
Oseltamivir Approved Phase 2 196618-13-0, 204255-11-8 65028
5
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
6
Ribavirin Approved Phase 2 36791-04-5 37542
7 Antibodies Phase 2
8 Immunoglobulins Phase 2
9 Anti-Asthmatic Agents Phase 2
10 Anti-Inflammatory Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Antipyretics Phase 2
13 Budesonide, Formoterol Fumarate Drug Combination Phase 2
14 Formoterol Fumarate Phase 2
15 gamma-Globulins Phase 2
16 glucocorticoids Phase 2
17 Hormone Antagonists Phase 2
18 Hormones Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Immunoglobulins, Intravenous Phase 2
21 Leukotriene Antagonists Phase 2
22 Respiratory System Agents Phase 2
23 Rho(D) Immune Globulin Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Active, not recruiting NCT02036970 Phase 2 Bardoxolone methyl;Placebo
2 Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant Terminated NCT01432080 Phase 2 Prednisone;Azithromycin;Montelukast;Symbicort
3 Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank Recruiting NCT02951416

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Cochrane evidence based reviews: cryptogenic organizing pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

Anatomical Context for Cryptogenic Organizing Pneumonia

MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

38
Lung, Breast, Neutrophil, Colon, Kidney

Publications for Cryptogenic Organizing Pneumonia

Articles related to Cryptogenic Organizing Pneumonia:

(show top 50) (show all 94)
# Title Authors Year
1
Cryptogenic organizing pneumonia masquerading as lung carcinoma: A case report and review of the literature. ( 29399056 )
2018
2
Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants. ( 28960643 )
2018
3
Cryptogenic Organizing Pneumonia With Lung Nodules Secondary to Pulmonary Manifestation of Crohn Disease. ( 28579861 )
2017
4
Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia. ( 28348912 )
2017
5
Retrospective evaluation of patients with organizing pneumonia: is cryptogenic organizing pneumonia different from secondary organizing pneumonia? ( 28621243 )
2017
6
Radial Probe Endobronchial Ultrasound-guided Lung Biopsy for Histopathological Diagnosis of Cryptogenic Organizing Pneumonia. ( 28091418 )
2017
7
Cicatricial variant of cryptogenic organizing pneumonia. ( 28412206 )
2017
8
Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study. ( 28945804 )
2017
9
Cryptogenic Organizing Pneumonia: IL-1I^, IL-6, IL-8, and TGF- I^1 Serum Concentrations and Response to Clarithromycin Treatment. ( 26987326 )
2016
10
Cryptogenic organizing pneumonia: clinical and radiological features, treatment outcomes of 17 patients, and review of the literature. ( 28081314 )
2016
11
Spontaneous resolution of cryptogenic organizing pneumonia in pediatrics: A case report. ( 27021808 )
2016
12
Azacitidine-induced cryptogenic organizing pneumonia: a case report and review of the literature. ( 26791087 )
2016
13
Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. ( 28028949 )
2016
14
Erythema gyratum repens associated with cryptogenic organizing pneumonia. ( 26765132 )
2016
15
A Case of Cryptogenic Organizing Pneumonia after Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma. ( 26508948 )
2015
16
Macrolide therapy in cryptogenic organizing pneumonia: A case report and literature review. ( 25667636 )
2015
17
Haemoptysis as a primary manifestation of cryptogenic organizing pneumonia (COP). ( 27451594 )
2015
18
Increased Galectin-9 Concentration and Number of CD4+Foxp3high+Cells in Bronchoalveolar Lavage Fluid of Patients with Cryptogenic Organizing Pneumonia. ( 26249221 )
2015
19
Successful Rituximab Therapy in Steroid-Resistant, Cryptogenic Organizing Pneumonia: A Case Series. ( 26045243 )
2015
20
Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. ( 26508933 )
2015
21
Reversed Halo Sign. A Case of Cryptogenic Organizing Pneumonia with Spontaneous Resolution. ( 26131991 )
2015
22
Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia. ( 24460438 )
2014
23
Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature. ( 25674228 )
2014
24
Fatal case of cryptogenic organizing pneumonia associated with Everolimus. ( 25827702 )
2014
25
Association of cryptogenic organizing pneumonia in bilateral anterior uveitis. ( 25520652 )
2014
26
The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography. ( 25493105 )
2014
27
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. ( 24396439 )
2014
28
Bronchoalveolar lavage fluid and blood natural killer and natural killer T-like cells in cryptogenic organizing pneumonia. ( 24889556 )
2014
29
Cryptogenic organizing pneumonia in Sweet's syndrome: case report and review of the literature. ( 25196175 )
2014
30
Autopsy findings of fatal cryptogenic organizing pneumonia. ( 23696931 )
2013
31
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. ( 24342432 )
2013
32
Pre-transplant risk factors for cryptogenic organizing pneumonia/bronchiolitis obliterans organizing pneumonia after hematopoietic cell transplantation. ( 23933758 )
2013
33
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. ( 24090908 )
2013
34
Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. ( 22842502 )
2013
35
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. ( 22688586 )
2013
36
Cryptogenic organizing pneumonia with fatal respiratory failure. ( 22372175 )
2012
37
Cryptogenic organizing pneumonia. ( 23001801 )
2012
38
Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis. ( 21675931 )
2012
39
Rituximab-related cryptogenic organizing pneumonia and late onset neutropenia in a patient with non-Hodgkin lymphoma: report of two rare complications and review of the literature. ( 23033310 )
2012
40
Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man. ( 23569519 )
2012
41
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. ( 21169342 )
2011
42
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. ( 22109285 )
2011
43
Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid. ( 21372463 )
2011
44
Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. ( 21144722 )
2011
45
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. ( 21093240 )
2011
46
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. ( 21297329 )
2011
47
Cryptogenic organizing pneumonia mimicking malignancy in a patient with rheumatoid arthritis. ( 21885507 )
2011
48
Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease. ( 20140460 )
2010
49
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. ( 20696310 )
2010
50
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. ( 20668958 )
2010

Variations for Cryptogenic Organizing Pneumonia

Expression for Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for Cryptogenic Organizing Pneumonia

GO Terms for Cryptogenic Organizing Pneumonia

Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.56 LAMC2 MMP9 TIMP1 TNC
2 extracellular space GO:0005615 9.5 CXCL8 LAMC2 MMP9 MUC1 MUC5B TIMP1
3 basement membrane GO:0005604 9.33 LAMC2 TIMP1 TNC
4 extracellular region GO:0005576 9.23 CD8A CXCL8 LAMC2 MMP9 MUC1 MUC5B

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.16 MUC1 MUC5B
2 extracellular matrix organization GO:0030198 9.13 LAMC2 MMP9 TNC
3 extracellular matrix disassembly GO:0022617 8.8 LAMC2 MMP9 TIMP1

Sources for Cryptogenic Organizing Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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