COP
MCID: CRY001
MIFTS: 41

Cryptogenic Organizing Pneumonia (COP) malady

Respiratory category

Summaries for Cryptogenic Organizing Pneumonia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Cryptogenic organizing pneumonia (cop) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. cop often affects adults in midlife (40 to 60 years of age). no predisposing factors have been identified and the cause is often unknown. diagnosis may be made through computed tomography (ct) scan or lung biopsy. response to treatment with corticosteroids is generally favorable. last updated: 3/15/2013

MalaCards: Cryptogenic Organizing Pneumonia, also known as bronchiolitis obliterans organizing pneumonia, is related to ulcerative colitis and bronchiolitis. An important gene associated with Cryptogenic Organizing Pneumonia is LAMC2 (laminin, gamma 2), and among its related pathways are Legionellosis and Immune response Bacterial infections in normal airways. The compounds cilomilast and n-tosyl-l-phenylalanine chloromethyl ketone have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and lung, and related mouse phenotype immune system.

Disease Ontology:8 A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). a flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. frequent presence of crackling sounds (called velcro crackles) when the doctor listens with a stethoscope.

Wikipedia:64 Bronchiolitis obliterans organizing pneumonia (BOOP) is a non-infectious pneumonia; specifically, an... more...

Aliases & Classifications for Cryptogenic Organizing Pneumonia

Sources:
49Orphanet, 61UMLS, 8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Characteristics (Orphanet epidemiological data):

49
cryptogenic organizing pneumonia:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cryptogenic organizing pneumonia 8 43 10 49
bronchiolitis obliterans organizing pneumonia 49 61
idiopathic bronchiolitis obliterans with organizing pneumonia 8
idiopathic bronchiolitis obliterans organizing pneumonia 43
cryptogenic organizing pneumonitis 8
idiopathic boop 43
cop 43


External Ids:

Disease Ontology8 DOID:0050157
MESH via Orphanet36 D018549
ICD10 via Orphanet26 J84.8

Related Diseases for Cryptogenic Organizing Pneumonia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cryptogenic Organizing Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.0TNF, IL8, LAMC2
2bronchiolitis30.9IL8
3bronchiolitis obliterans30.8IL8
4adult respiratory distress syndrome30.6IL8, TNF
5arthritis30.5TNF, IL8
6idiopathic pulmonary fibrosis30.5TNC, IL8, LAMC2
7systemic lupus erythematosus10.8
8bronchiolitis obliterans organizing pneumonia10.6
9graft versus host disease10.6
10polymyositis10.6
11chronic eosinophilic pneumonia10.5
12char syndrome10.5
13chronic graft versus host disease10.5
14usual interstitial pneumonia10.5
15adult syndrome10.5
16cryoglobulinemia10.4
17cystic fibrosis10.4
18evans' syndrome10.4
19hepatitis c10.4
20primary biliary cirrhosis10.4
21common variable immunodeficiency10.4
22wegener's granulomatosis10.4
23melioidosis10.4
24lung lymphoma10.4
25plasmodium vivax malaria10.4
26juvenile rheumatoid arthritis10.4
27acquired immunodeficiency syndrome10.4
28hepatitis b10.4
29polymyalgia rheumatica10.4
30cryptococcosis10.4
31sclerosing cholangitis10.4
32n syndrome10.4
33acute leukemia10.4
34hepatitis a10.4
35aspiration pneumonia10.4
36asthma10.4
37acute graft versus host disease10.4
38primary sclerosing cholangitis10.4
39cutaneous sclerosis10.4
40mycobacterium kansasii10.4
41pediatric ulcerative colitis10.4
42radiation induced cancer10.4
43spontaneous pneumothorax10.4
44cytomegalovirus infection10.4
45bronchiolitis obliterans with obstructive pulmonary disease10.4
46hematopoietic stem cell transplantation10.4
47acute interstitial pneumonia10.2
48pulmonary tuberculosis10.2
49adult-onset still's disease10.2
50tuberculosis10.2

Graphical network of the top 20 diseases related to Cryptogenic Organizing Pneumonia:



Diseases related to cryptogenic organizing pneumonia

Clinical Features for Cryptogenic Organizing Pneumonia

Drugs & Therapeutics for Cryptogenic Organizing Pneumonia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cryptogenic Organizing Pneumonia

Drug clinical trials:

Search ClinicalTrials for Cryptogenic Organizing Pneumonia

Search NIH Clinical Center for Cryptogenic Organizing Pneumonia

Search CenterWatch for Cryptogenic Organizing Pneumonia

Genetic Tests for Cryptogenic Organizing Pneumonia

Anatomical Context for Cryptogenic Organizing Pneumonia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cryptogenic Organizing Pneumonia:

33
Colon, Kidney, Lung, Breast

Animal Models for Cryptogenic Organizing Pneumonia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cryptogenic Organizing Pneumonia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7LAMC2, IL8, ING4, TOMM5, TNF

Publications for Cryptogenic Organizing Pneumonia

Sources:
51PubMed
See all sources

Articles related to Cryptogenic Organizing Pneumonia:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Cryptogenic organizing pneumonia associated with radiation: A report of two cases. (24396439)
2014
2
Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. (24342432)
2013
3
Cryptogenic organizing pneumonia: A rare extra-intestinal manifestation of Crohn's disease. (24090908)
2013
4
Cryptogenic organizing pneumonia in Tomm5(-/-) mice. (22688586)
2013
5
Cryptogenic organizing pneumonia with fatal respiratory failure. (22372175)
2012
6
Cryptogenic organizing pneumonia. (23001801)
2012
7
Simultaneous diagnosis of cryptogenic organizing pneumonia and HIV in a 45 year old man. (23569519)
2012
8
Rituximab-related cryptogenic organizing pneumonia and late onset neutropenia in a patient with non-Hodgkin lymphoma: report of two rare complications and review of the literature. (23033310)
2012
9
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia. (22109285)
2011
10
Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia. (21169342)
2011
11
Optimizing the utility of high-resolution computed tomography in diagnosing cryptogenic organizing pneumonia. (21093240)
2011
12
A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. (21297329)
2011
13
Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. (21144722)
2011
14
Cryptogenic organizing pneumonia mimicking malignancy in a patient with rheumatoid arthritis. (21885507)
2011
15
Cryptogenic organizing pneumonia due to amiodarone: long-term follow-up after corticosteroid treatment. (20668958)
2010
16
Utility of high-resolution computed tomography and BAL in cryptogenic organizing pneumonia. (20594817)
2010
17
Re: Reversed halo sign: nodular wall as criterion for differentiation between cryptogenic organizing pneumonia and active granulomatous diseases. (20696310)
2010
18
Cryptogenic organizing pneumonia after radiotherapy for breast cancer. (22958364)
2010
19
Cryptogenic organizing pneumonia: serial high-resolution CT findings in 22 patients. (20858818)
2010
20
Elevated levels of thioredoxin 1 in the lungs and sera of idiopathic pulmonary fibrosis, non-specific interstitial pneumonia and cryptogenic organizing pneumonia. (21088339)
2010
21
Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease. (20140460)
2010
22
Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review. (20222953)
2010
23
Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature. (19093118)
2009
24
Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. (19650943)
2009
25
Comparison of pulmonary CT findings and serum KL-6 levels in patients with cryptogenic organizing pneumonia. (19064594)
2009
26
Elevated levels of tenascin-C in patients with cryptogenic organizing pneumonia. (19721293)
2009
27
Cryptogenic organizing pneumonia: clinical profile in a series of 34 admitted patients in a hospital in India. (18702383)
2008
28
Chronic panuveitis and scleritis in a patient with cryptogenic organizing pneumonia. (17180535)
2006
29
Cryptogenic organizing pneumonia: variety of radiologic findings. (16190479)
2005
30
Cryptogenic organizing pneumonia. (15564018)
2004
31
Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. (14500258)
2004
32
Azathioprine and low-dose corticosteroids for the treatment of cryptogenic organizing pneumonia in an older patient. (12588596)
2003
33
The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia. (12006432)
2002
34
Cryptogenic organizing pneumonia. (16088692)
2001
35
Cryptogenic organizing pneumonia is an important cause of graft dysfunction and should be included in the classification of pulmonary allograft rejection. (9513862)
1998
36
Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors. (9310948)
1997
37
Bronchoalveolar lavage, histological and immunohistochemical features in cryptogenic organizing pneumonia. (8909012)
1996
38
Neutrophil chemotactic activity in cryptogenic organizing pneumonia and the response to erythromycin. (8942140)
1996
39
Should cryptogenic organizing pneumonia be included in the classification of pulmonary allograft rejection? (8981212)
1996
40
The diagnostic value of bronchoalveolar lavage and transbronchial lung biopsy in cryptogenic organizing pneumonia. (8980962)
1996
41
Anti-Jo-1 syndrome presenting as cryptogenic organizing pneumonia. (7494922)
1995
42
Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature. (7623655)
1995
43
Cryptogenic organizing pneumonia in the immunocompromised patient: radiologic findings and follow-up in 12 patients. (7543802)
1995
44
Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. (8292374)
1994
45
Cryptogenic organizing pneumonia with atypical histopathological features. (8147799)
1994
46
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis. (8313666)
1993
47
The histological diagnosis of clinically documented cases of cryptogenic organizing pneumonia: diagnostic features in transbronchial biopsies. (8314237)
1993
48
What are bronchiolitis obliterans organizing pneumonia (BOOP) and cryptogenic organizing pneumonia (COP)? (1606792)
1992
49
The radiology and terminology of cryptogenic organizing pneumonia. (1393393)
1992
50
Obliterative bronchiolitis, cryptogenic organising pneumonitis and bronchiolitis obliterans organizing pneumonia: three names for two different conditions. (1954996)
1991

Genetic Variations for Cryptogenic Organizing Pneumonia

Expression for genes affiliated with Cryptogenic Organizing Pneumonia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptogenic Organizing Pneumonia

Search GEO for disease gene expression data for Cryptogenic Organizing Pneumonia.

Pathways for genes affiliated with Cryptogenic Organizing Pneumonia

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNF, IL8
2
Immune response Bacterial infections in normal airways
9.5IL8, TNF
39.5IL8, TNF
4
Hide members
9.5IL8, TNF
59.5IL8, TNF
69.5TNF, IL8
79.5IL8, TNF
89.1LAMC2, IL8, TNF
9
Cell adhesion ECM remodeling
Hide members
9.0LAMC2, IL8, TNC
10
Hide members
8.5TNC, TNF, IL8, LAMC2

Compounds for genes affiliated with Cryptogenic Organizing Pneumonia

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1cilomilast459.9IL8, TNF
2n-tosyl-l-phenylalanine chloromethyl ketone459.9IL8, TNF
3taurine chloramine459.9TNF, IL8
4gabexate mesilate459.9IL8, TNF
5toxin-1459.9TNF, IL8
6ulinastatin459.9TNF, IL8
7mip 1alpha459.9IL8, TNF
8gold sodium thiomalate459.9IL8, TNF
9il-12459.9TNF, IL8
105 aminosalicylic acid459.9TNF, IL8
11staurosporin459.9IL8, TNF
12imiquimod45 29 60 1112.9TNF, IL8
13tpck459.9TNF, IL8
14polymyxin b459.9IL8, TNF
15groalpha459.9TNF, IL8
16go 697645 6010.9TNF, IL8
17triptolide459.9TNF, IL8
18gm-csf45 2910.9TNF, IL8
19budesonide45 50 1111.8TNF, IL8
20ciglitazone45 2910.8TNF, IL8
21parthenolide45 210.8TNF, IL8
22sulfasalazine45 29 50 1112.8TNF, IL8
23lipoteichoic acid459.8TNF, IL8
248-isoprostane459.8TNF, IL8
25fluticasone propionate45 50 60 1112.8TNF, IL8
26ns 39845 6010.8IL8, TNF
27polyinosinic-polycytidylic acid459.8IL8, TNF
28etanercept45 50 1111.7TNF, IL8
29rolipram45 60 2911.7IL8, TNF
30poly(i-c)459.7IL8, TNF
31il 10459.7TNF, IL8
32diphenyleneiodonium459.6IL8, TNF
33tarc459.6TNF, IL8
34peptidoglycan45 2910.6IL8, TNF
35n-formylmethionyl-leucylphenylalanine459.5IL8, TNF
3615-deoxy-delta-12,14-prostaglandin j2459.5IL8, TNF
37ccl345 2910.4TNF, IL8
38ly294002459.2IL8, TNF, TNC
39neopterin459.2IL8, TNF
40actinomycin d459.1TNC, TNF, IL8

GO Terms for genes affiliated with Cryptogenic Organizing Pneumonia

Sources:
16Gene Ontology
See all sources

Cellular components related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5LAMC2, IL8, TNF, TNC

Biological processes related to Cryptogenic Organizing Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.5IL8, TNF
2calcium-mediated signalingGO:0197229.2TNF, IL8
3negative regulation of cell proliferationGO:0082859.0IL8, ING4, TNF
4extracellular matrix organizationGO:0301988.8LAMC2, TNF, TNC

Products for genes affiliated with Cryptogenic Organizing Pneumonia

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Cryptogenic Organizing Pneumonia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet