MCID: CRY002
MIFTS: 62

Cryptorchidism malady

Categories: Genetic diseases (common), Reproductive diseases

Aliases & Classifications for Cryptorchidism

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Aliases & Descriptions for Cryptorchidism:

Name: Cryptorchidism 51 11 69 26 12 49 38 13
Cryptorchidism, Unilateral or Bilateral 26
Impaired Testicular Descent 69
Undescended Testicles 11
Undescended Testicle 11
 
Undescended Testis 11
Cryptosporidiosis 67
Cryptorchism 11
Crypto 69

Classifications:



External Ids:

OMIM51 219050
Disease Ontology11 DOID:11383
ICD9CM31 752.51
MeSH38 D003456
NCIt44 C12326
MedGen36 C0010417

Summaries for Cryptorchidism

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OMIM:51 Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial... (219050) more...

MalaCards based summary: Cryptorchidism, also known as cryptorchidism, unilateral or bilateral, is related to noonan syndrome 7 and hypogonadism, and has symptoms including pruritus, renal agenesis and unilateral cryptorchidism. An important gene associated with Cryptorchidism is INSL3 (Insulin Like 3), and among its related pathways are Hormone ligand-binding receptors and pilocytic astrocytoma. The drug nitazoxanide has been mentioned in the context of this disorder. Affiliated tissues include testis, testes and pituitary, and related mouse phenotypes are neoplasm and embryo.

UniProtKB/Swiss-Prot:69 Cryptorchidism: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Wikipedia:70 Cryptorchidism is the absence of one or both testes from the scrotum. It is the most common birth defect... more...

Related Diseases for Cryptorchidism

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Diseases related to Cryptorchidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1noonan syndrome 731.6PTPN11, RAF1, SOS1
2hypogonadism30.0AMH, AR, INSL3, SHBG
3pfeiffer syndrome29.8ALPPL2, CGB5, NR5A1
4malignant tumor of undescended testis12.3
5torticollis, keloids, cryptorchidism, and renal dysplasia12.0
6anophthalmia esophageal atresia cryptorchidism11.7
7cryptorchidism arachnodactyly mental retardation11.7
8cryptorchidism-arachnodactyly-intellectual disability syndrome11.7
9intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome11.7
10spigelian hernia-cryptorchidism syndrome11.7
11x-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome11.7
12prune belly syndrome11.6
13cryptosporidiosis11.6
14ifap syndrome with or without bresheck syndrome11.4
15fetal akinesia deformation sequence11.3
16mcdonough syndrome11.0
17testicular microlithiasis11.0
18noonan syndrome 110.8
19noonan syndrome 910.8
20carpenter syndrome 210.8
21noonan syndrome 1010.8
22mental retardation, autosomal dominant 1710.7
23arroyo garcia cimadevilla syndrome10.7
24caudal appendage deafness10.7
25duker weiss siber syndrome10.7
26pacs1-related syndrome10.7
27singh chhaparwal dhanda syndrome10.7
28van benthem-driessen-hanveld syndrome10.7
29noonan syndrome 610.6
30noonan syndrome 810.6
31noonan syndrome 410.6
32filippi syndrome10.6
33noonan syndrome 510.6
34nablus mask-like facial syndrome10.6
35bowen-conradi syndrome10.6
36noonan syndrome 310.6
37omodysplasia 110.6
38myhre syndrome10.6
39lateral meningocele syndrome10.6
40spinal muscular atrophy, x-linked 2, infantile10.6
41mental retardation, x-linked, syndromic, claes-jensen type10.6
42ohdo syndrome, x-linked10.6
43escobar syndrome10.6
44chromosome 7q11.23 duplication syndrome10.6
45proud syndrome10.6
46exstrophy of bladder bladder exstrophy and epispadias complex, included10.6
47syndromic x-linked intellectual disability siderius type10.6
4846,xx testicular disorder of sex development10.6
49short stature wormian bones dextrocardia10.6
50recombinant 8 syndrome10.6

Graphical network of the top 20 diseases related to Cryptorchidism:



Diseases related to cryptorchidism

Symptoms for Cryptorchidism

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Symptoms by clinical synopsis from OMIM:

219050

Clinical features from OMIM:

219050

Human phenotypes related to Cryptorchidism:

 63
id Description HPO Frequency HPO Source Accession
1 renal agenesis63 HP:0000104
2 unilateral cryptorchidism63 HP:0012741

UMLS symptoms related to Cryptorchidism:


pruritus

Drugs & Therapeutics for Cryptorchidism

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Drugs for Cryptorchidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Sevofluraneapproved, vet_approvedPhase 4, Phase 247928523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
2
Propofolapproved, investigational, vet_approvedPhase 410282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
3AnestheticsPhase 4, Phase 29001
4Anesthetics, IntravenousPhase 42406
5Anesthetics, GeneralPhase 4, Phase 22787
6Central Nervous System DepressantsPhase 4, Phase 212806
7Hypnotics and SedativesPhase 4, Phase 22485
8
Dexmedetomidineapproved, vet_approvedPhase 254076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
9
BenzocaineapprovedPhase 218921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
10
LevobupivacaineapprovedPhase 216527262-47-192253
Synonyms:
(-)-Bupivacaine
(-)-bupivacaine
(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(S)-1-Butyl-2',6'-pipecoloxylidide
(S)-Bupivacaine
(S)-bupivacaine
27262-47-1
27262-48-2
AC1L3NQM
BIDD:GT0471
C07887
C18H28N2O
CAS-18010-40-7
CHEBI:6149
CID92253
D08116
 
DB01002
L(-)-Bupivacaine
L-(-)-1-Butyl-2',6'-pipecoloxylidide
L-(-)-Bupivacaine
L-(-)-bupivacaine
LS-109843
LS-187025
LS-187789
Levobupivacaine
Levobupivacaine (INN)
Levobupivacaine [INN:BAN]
Levobupivacaine hydrochloride
MolPort-004-959-713
NCGC00016733-01
NCGC00159482-02
Novabupi
Novabupi (TN)
11
Bupivacaineapproved, investigationalPhase 211312180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
12tannic acidapproved, NutraceuticalPhase 21892
13Anesthetics, LocalPhase 23272
14Platelet Aggregation InhibitorsPhase 22419
15Peripheral Nervous System AgentsPhase 222776
16Neurotransmitter AgentsPhase 217734
17Adrenergic AgentsPhase 25140
18NarcoticsPhase 23486
19Anesthetics, InhalationPhase 2649
20Adrenergic alpha-2 Receptor AgonistsPhase 2911
21Adrenergic AgonistsPhase 22877
22Analgesics, Non-NarcoticPhase 26260
23AnalgesicsPhase 211287
24Adrenergic alpha-AgonistsPhase 21625
25
Dexamethasoneapproved, investigational, vet_approved208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
26
Ropivacaineapproved74184057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
27Hormones13979
28Hormones, Hormone Substitutes, and Hormone Antagonists12767
29Androgens1275
30Hormone Antagonists12778
31Estrogens2470
32glucocorticoids4920
33HIV Protease Inhibitors5319
34
protease inhibitors5320
Synonyms:
 
protease inhibitors
35Antiemetics3888
36Gastrointestinal Agents8109
37Dexamethasone acetate20841177-87-3
38Autonomic Agents9774
39BB 11012084
40Anti-Inflammatory Agents10355
41Dexamethasone 21-phosphate2084
42Antineoplastic Agents, Hormonal5407

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1The Effect of Induction Technique on Postoperative Pain and AgitationCompletedNCT02110745Phase 4
2Comparing Oxygen Saturation in Post Anesthesia Care Unit After Different Methods of Pain ReliefCompletedNCT00435383Phase 2
3Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in ChildrenCompletedNCT01701778Phase 2
4The Incidence of Congenital Undescended Testis Among Dutch InfantsUnknown statusNCT00264121
5Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenUnknown statusNCT00150163
6Cryptorchidism: Impact of in Utero Exposure to Xenobiotics With Hormonal ActionCompletedNCT00565513
7A Novel Technique of Circumcision Incision OrchidopexyCompletedNCT02249637
8Long-Term Outcome in Congenital Undescended Testis After Surgical Treatment by OrchidopexyCompletedNCT00253253
9Comparison of Dexamethasone Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia in Children Undergoing OrchiopexyCompletedNCT01604915
10Can the Hypertrophy of Contralateral Testis Predict the Absence of the Non-palpable Testis in the Boys Aged From 6months to 18months of Age ?CompletedNCT02203318
11Visual Guidelines and Tutoring in Pediatric Urological SurgeryCompletedNCT02040389
12The Caudal Space in Children: Ultrasound EvaluationCompletedNCT01896076
13A Case-Control Study of Testicular Germ Cell Tumors Among U.S. Military ServicemenCompletedNCT00341588
14Genetics of Familial Testicular CancerCompletedNCT00342537
15Orchidopexy Randomized Clinical AssessmentRecruitingNCT02235623
16Expertise-Based Randomized Controlled Trial of Scrotal Versus Inguinal Orchidopexy on Post-operative PainRecruitingNCT02158780
17DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or SiblingsRecruitingNCT01434355
18The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome)RecruitingNCT01601171
19Comparison Between the Clinical Assessment of the Undescended Testis and Its' Ultrasonographic SizeNot yet recruitingNCT02731989
20One Stage vs. Two Stage Gubernaculum Sparing Laparoscopic Orchidopexy: A Randomized Controlled TrialNot yet recruitingNCT02936024

Search NIH Clinical Center for Cryptorchidism

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: cryptorchidism

Genetic Tests for Cryptorchidism

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Genetic tests related to Cryptorchidism:

id Genetic test Affiliating Genes
1 Cryptorchidism, Unilateral or Bilateral26
2 Cryptorchidism26

Anatomical Context for Cryptorchidism

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MalaCards organs/tissues related to Cryptorchidism:

35
Testis, Testes, Pituitary, Breast, Placenta, Heart, Prostate

Animal Models for Cryptorchidism or affiliated genes

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MGI Mouse Phenotypes related to Cryptorchidism:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2AMH, AR, GNRH1, PTPN11, RAF1, RXFP2
2MP:00053809.7ALPPL2, AR, FGFR1, LBX1, NR5A1, PTPN11
3MP:00028739.6ALPPL2, AR, FGFR1, GNRH1, LBX1, NR5A1
4MP:00036319.3AR, CGA, FGFR1, GNRH1, HOXA10, LBX1
5MP:00053799.3AMH, AR, CGA, FGFR1, GNRH1, HOXA10
6MP:00053899.2ALPPL2, AMH, AR, CGA, FGFR1, GNRH1
7MP:00053789.0ALPPL2, AR, CGA, FGFR1, GNRH1, HOXA10
8MP:00053909.0AR, FGFR1, GNRH1, HOXA10, INSL3, PTPN11

Publications for Cryptorchidism

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Articles related to Cryptorchidism:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Commentary to 'Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism'. (27346070)
2016
2
Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. (27769252)
2016
3
Prenatal diagnosis of cryptorchid testicular teratoma. (27081226)
2016
4
Laparoscopic treatment for inguinal hernia combined with cryptorchidism: Totally extraperitoneal repair with orchiectomy under the same operative view. (26581081)
2015
5
Evaluation and management of the infant with cryptorchidism. (26087417)
2015
6
Operative management of cryptorchidism: guidelines and reality--a 10-year observational analysis of 3587 cases. (26357871)
2015
7
Severe short stature, profound microcephaly, developmental brain abnormality, agenesis of optic disc and retinal vessels, and bilateral cryptorchidism in two male siblings: a new lethal recessively inherited syndrome. (25090031)
2014
8
A genome-wide association study for canine cryptorchidism in Siberian Huskies. (24268032)
2013
9
Cryptorchidism. (23493040)
2013
10
Supernumerary kidney with ipsilateral cryptorchidism in a cat. (23861269)
2013
11
The regulation of testicular descent and the effects of cryptorchidism. (23666148)
2013
12
Wnt signalling in testicular descent: a candidate mechanism for cryptorchidism in Robinow syndrome. (23895974)
2013
13
Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. (23423470)
2012
14
Serum AMH concentration as a marker evaluating gonadal function in boys operated on for unilateral cryptorchidism between 1st and 4th year of life. (22038452)
2012
15
Is laparoscopic re-evaluation justified in cryptorchidism with previous negative open exploration? (22168768)
2012
16
Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias. (22648180)
2012
17
Impact of anatomical and socioeconomic factors on timing of urological consultation for boys with cryptorchidism. (21855921)
2011
18
ESR1 promoter polymorphism is not associated with nonsyndromic cryptorchidism. (20887985)
2011
19
Bilateral abdominal cryptorchidism with large left testicular seminoma and failed right urogenital union. (21219387)
2011
20
The risk of cryptorchidism among sons of women working in horticulture in Denmark: a cohort study. (22082298)
2011
21
What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesis. (20920735)
2010
22
Splenogonadal fusion presented with cryptorchidism. (19472134)
2009
23
Epidemiology and pathogenesis of cryptorchidism. (18032558)
2008
24
Cryptorchidism: classification, prevalence and long-term consequences. (17462053)
2007
25
Efficacy and safety of hormonal treatment of cryptorchidism: current state of the art. (17462056)
2007
26
Is the prohibition of hormonal treatment for cryptorchidism, as suggested by the Nordic consensus group, justifiable? (17718795)
2007
27
Mild gestational diabetes as a risk factor for congenital cryptorchidism. (17032715)
2006
28
Persistent pesticides in human breast milk and cryptorchidism. (16835070)
2006
29
Cryopreservation of intact testicular tissue from boys with cryptorchidism. (16210383)
2006
30
Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism. (15757859)
2005
31
Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1 year follow-up. (15860495)
2005
32
3C syndrome with cryptorchidism and posterior embryotoxon. (15770133)
2005
33
Role of INSL3 and LGR8 in cryptorchidism and testicular functions. (15353080)
2004
34
Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys. (15531444)
2004
35
Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. (15636430)
2004
36
The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. (12970298)
2003
37
Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy. (12699482)
2003
38
Absence of microdeletions in the Y chromosome in patients with Prader-Willi syndrome with cryptorchidism. (11869370)
2002
39
Cryptorchidism. (12518213)
2002
40
Leydig cell function after cryptorchidism: evidence of the beneficial result of early surgery. (11912442)
2002
41
Controversy in cryptorchidism: the value of laparoscopy and fertility outcomes. (11397487)
2001
42
The effect of the genitofemoral nerve division on the contralateral descended testis in the unilateral cryptorchidism model. (11527180)
2001
43
Hormonal therapy for the subfertility of cryptorchidism. (11423741)
2001
44
Comparative studies of fertility and histologic development of contralateral scrotal testes in two rat models of unilateral cryptorchidism. (11057551)
2000
45
Decreased expression of mouse Rbm3, a cold-shock protein, in Sertoli cells of cryptorchid testis. (10793079)
2000
46
Apoptotic cell death in the normal and cryptorchid human testis: the effect of human chorionic gonadotropin on testicular cell survival. (8827789)
1996
47
Cryptorchidism]. (1361054)
1992
48
Klinefelter's syndrome associated with unilateral cryptorchidism and chordee without hypospadia. (1357810)
1992
49
Omphalocele, cryptorchidism, and brain malformations. (2889822)
1987
50
X-linked ichthyosis and cryptorchidism. (2874061)
1986

Variations for Cryptorchidism

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UniProtKB/Swiss-Prot genetic disease variations for Cryptorchidism:

69
id Symbol AA change Variation ID SNP ID
1INSL3p.Pro93LeuVAR_013235rs104894697
2INSL3p.Arg102CysVAR_013236rs104894698
3INSL3p.Asn110LysVAR_017122rs121912555
4RXFP2p.Thr222ProVAR_015386rs28939382

Clinvar genetic disease variations for Cryptorchidism:

5
id Gene Variation Type Significance SNP ID Assembly Location
1INSL3NM_005543.3(INSL3): c.330C> G (p.Asn110Lys)SNVPathogenicrs121912555GRCh37Chr 19, 17927729: 17927729
2INSL3NM_005543.3(INSL3): c.278C> T (p.Pro93Leu)SNVPathogenicrs104894697GRCh37Chr 19, 17927781: 17927781
3INSL3NM_005543.3(INSL3): c.304C> T (p.Arg102Cys)SNVPathogenicrs104894698GRCh37Chr 19, 17927755: 17927755
4INSL3NM_005543.3(INSL3): c.305G> A (p.Arg102His)SNVPathogenicrs121912556GRCh37Chr 19, 17927754: 17927754
546;XY;t(5;15)(q11.2;q24)TranslocationPathogenicChr na, -1: -1
646;XY;t(6: 11)(p12.3;p14.2)dnTranslocationPathogenicChr na, -1: -1
7INSL3NM_005543.3(INSL3): c.217C> T (p.Arg73Ter)SNVPathogenicrs398122886GRCh37Chr 19, 17927842: 17927842

Copy number variations for Cryptorchidism from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
14506810670000012300000GainCryptorchidism
26227812107500000132349534GainCryptorchidism
389249151700000023300000LossCryptorchidism
42024475820000015100000GainCryptorchidism
5260236X146900000154913754GainCryptorchidism
6266753Y157772954MicrodeletionCryptorchidism

Expression for genes affiliated with Cryptorchidism

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Search GEO for disease gene expression data for Cryptorchidism.

Pathways for genes affiliated with Cryptorchidism

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GO Terms for genes affiliated with Cryptorchidism

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Cellular components related to Cryptorchidism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.9AMH, CGA, CGB5, FGFR1, GNRH1, IGFL3

Biological processes related to Cryptorchidism according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone metabolic processGO:004244510.5NR5A1, PTPN11
2oocyte maturationGO:000155610.4INSL3, RXFP2
3neurotrophin TRK receptor signaling pathwayGO:004801110.3PTPN11, RAF1, SOS1
4multicellular organism growthGO:003526410.3AR, PTPN11, SOS1
5male gonad developmentGO:000858410.0AR, HOXA10, INSL3, NR5A1, RXFP2
6cell-cell signalingGO:00072679.8AMH, AR, CGA, GNRH1, INSL3, NR5A1
7regulation of gene expressionGO:00104689.5AR, FGFR1, GNRH1, HOXA10
8negative regulation of cell proliferationGO:00082859.4AR, GNRH1, INSL3, LBX1, RAF1, RXFP2

Molecular functions related to Cryptorchidism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen bindingGO:000549710.5AR, SHBG
2hormone activityGO:00051799.8AMH, CGA, GNRH1, INSL3

Sources for Cryptorchidism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet