MCID: CRY002
MIFTS: 62

Cryptorchidism malady

Categories: Genetic diseases (common), Reproductive diseases

Aliases & Classifications for Cryptorchidism

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Aliases & Descriptions for Cryptorchidism:

Name: Cryptorchidism 52 11 70 27 12 50 39 13
Cryptorchidism, Unilateral or Bilateral 27
Impaired Testicular Descent 70
Undescended Testicles 11
Undescended Testicle 11
 
Undescended Testis 11
Cryptosporidiosis 68
Cryptorchism 11
Crypto 70

Classifications:



External Ids:

OMIM52 219050
Disease Ontology11 DOID:11383
ICD9CM32 752.51
MeSH39 D003456
NCIt45 C12326
MedGen37 C0010417

Summaries for Cryptorchidism

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OMIM:52 Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial... (219050) more...

MalaCards based summary: Cryptorchidism, also known as cryptorchidism, unilateral or bilateral, is related to noonan syndrome 7 and hypogonadism, and has symptoms including pruritus, renal agenesis and unilateral cryptorchidism. An important gene associated with Cryptorchidism is INSL3 (Insulin Like 3), and among its related pathways are Hormone ligand-binding receptors and pilocytic astrocytoma. The drug nitazoxanide has been mentioned in the context of this disorder. Affiliated tissues include testis, testes and pituitary, and related mouse phenotypes are neoplasm and embryo.

UniProtKB/Swiss-Prot:70 Cryptorchidism: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Wikipedia:71 Cryptorchidism is the absence of one or both testes from the scrotum. It is the most common birth defect... more...

Related Diseases for Cryptorchidism

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Diseases related to Cryptorchidism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1noonan syndrome 731.6PTPN11, RAF1, SOS1
2hypogonadism30.0AMH, AR, INSL3, SHBG
3pfeiffer syndrome29.8ALPPL2, CGB5, NR5A1
4malignant tumor of undescended testis12.3
5torticollis, keloids, cryptorchidism, and renal dysplasia12.0
6anophthalmia esophageal atresia cryptorchidism11.7
7cryptorchidism arachnodactyly mental retardation11.7
8cryptorchidism-arachnodactyly-intellectual disability syndrome11.7
9intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome11.7
10spigelian hernia-cryptorchidism syndrome11.7
11x-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome11.7
12prune belly syndrome11.6
13cryptosporidiosis11.6
14ifap syndrome with or without bresheck syndrome11.4
15fetal akinesia deformation sequence11.3
16mcdonough syndrome11.0
17testicular microlithiasis11.0
18noonan syndrome 110.8
19noonan syndrome 910.8
20carpenter syndrome 210.8
21noonan syndrome 1010.8
22mental retardation, autosomal dominant 1710.7
23arroyo garcia cimadevilla syndrome10.7
24caudal appendage deafness10.7
25duker weiss siber syndrome10.7
26pacs1-related syndrome10.7
27singh chhaparwal dhanda syndrome10.7
28van benthem-driessen-hanveld syndrome10.7
29noonan syndrome 610.6
30noonan syndrome 810.6
31noonan syndrome 410.6
32filippi syndrome10.6
33noonan syndrome 510.6
34nablus mask-like facial syndrome10.6
35bowen-conradi syndrome10.6
36noonan syndrome 310.6
37omodysplasia 110.6
38myhre syndrome10.6
39lateral meningocele syndrome10.6
40spinal muscular atrophy, x-linked 2, infantile10.6
41mental retardation, x-linked, syndromic, claes-jensen type10.6
42ohdo syndrome, x-linked10.6
43escobar syndrome10.6
44chromosome 7q11.23 duplication syndrome10.6
45proud syndrome10.6
46exstrophy of bladder bladder exstrophy and epispadias complex, included10.6
47syndromic x-linked intellectual disability siderius type10.6
4846,xx testicular disorder of sex development10.6
49short stature wormian bones dextrocardia10.6
50recombinant 8 syndrome10.6

Graphical network of the top 20 diseases related to Cryptorchidism:



Diseases related to cryptorchidism

Symptoms & Phenotypes for Cryptorchidism

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Symptoms by clinical synopsis from OMIM:

219050

Clinical features from OMIM:

219050

Human phenotypes related to Cryptorchidism:

 64
id Description HPO Frequency HPO Source Accession
1 renal agenesis64 HP:0000104
2 unilateral cryptorchidism64 HP:0012741

UMLS symptoms related to Cryptorchidism:


pruritus

MGI Mouse Phenotypes related to Cryptorchidism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2AMH, AR, GNRH1, PTPN11, RAF1, RXFP2
2MP:00053809.7ALPPL2, AR, FGFR1, LBX1, NR5A1, PTPN11
3MP:00028739.6ALPPL2, AR, FGFR1, GNRH1, LBX1, NR5A1
4MP:00036319.3AR, CGA, FGFR1, GNRH1, HOXA10, LBX1
5MP:00053799.3AMH, AR, CGA, FGFR1, GNRH1, HOXA10
6MP:00053899.2ALPPL2, AMH, AR, CGA, FGFR1, GNRH1
7MP:00053789.0ALPPL2, AR, CGA, FGFR1, GNRH1, HOXA10
8MP:00053909.0AR, FGFR1, GNRH1, HOXA10, INSL3, PTPN11

Drugs & Therapeutics for Cryptorchidism

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Drugs for Cryptorchidism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Sevofluraneapproved, vet_approvedPhase 4, Phase 247928523-86-65206
Synonyms:
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
28523-86-6
AC-15484
AC1L1JU0
BRN 2041023
Bax 3084
C009250
C07520
C4H3F7O
CHEBI:9130
CHEMBL1200694
CID5206
D00547
DB01236
F0691
Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
I14-13357
LS-67851
MR6S4
 
MR_6S4
MolPort-001-775-746
NCGC00167421-01
PC4681
Sevofluran
Sevoflurane
Sevoflurane (JAN/USAN/INN)
Sevoflurane [USAN:INN:BAN:JAN]
Sevoflurano
Sevoflurano [INN-Spanish]
Sevofluranum
Sevofluranum [INN-Latin]
Sevofrane
Sevorane
Sojourn
UNII-38LVP0K73A
Ultane
Ultane (TN)
ZINC01530810
fluoromethyl hexafluoroisopropyl ether
fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
sevoflurane
2
Propofolapproved, investigational, vet_approvedPhase 410282078-54-84943
Synonyms:
2, 6-Diisopropylphenol
2,6 Diisopropylphenol
2,6-Bis(1-methylethyl)phenol
2,6-Bis(Isopropyl)-phenol
2,6-DIISOPROPYLPHENOL
2,6-Diisopropyl phenol
2,6-Diisopropylphenol
2,6-bis(1-methylethyl)-phenol
2,6-di(propan-2-yl)phenol
2078-54-8
28449-97-0
4-06-00-03435 (Beilstein Handbook Reference)
50356-15-5
AB00513968
AC-2038
AC1L1J9Y
AC1Q1OUI
AI3-26295
AM-149
Abbott Brand of Propofol
Alpha Brand of Propofol
Ampofol
Aquafol
Astra Brand of Propofol
AstraZeneca Brand of Propofol
BIDD:GT0436
BPBio1_000950
BPBio1_000969
BRD-K82255054-001-03-5
BRN 1866484
BSPBio_000862
Biomol-NT_000248
Braun Brand of Propofol
C07523
C12H18O
CAS-2078-54-8
CCRIS 9000
CHEBI:44915
CHEMBL526
CID4943
CPD-11437
CPD000059151
Curamed Brand of Propofol
D00549
D015742
D0617
D126608
D126608_ALDRICH
DB00818
DDS-04F
Diisopropylphenol
Dipravan
Diprivan
Diprivan (TN)
Diprivan Injectable emulsion
Disoprivan
Disoprofol
EINECS 218-206-6
EU-0100437
Fresenius Brand of Propofol
Fresenius Kabi Brand of Propofol
Fresofol
HMS1570L04
HMS2089O21
HMS2094E17
 
HSDB 7123
ICI 35,868
ICI 35868
ICI-35,868
ICI-35868
ICI35,868
ICI35868
InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H
Ivofol
Jsp004266
Juste Brand of Propofol
LS-996
Lopac-D126608
Lopac0_000437
MLS001066348
MLS001335999
MLS002454360
MolPort-001-794-517
NCGC00015389-01
NCGC00015389-02
NCGC00015389-04
NCGC00015389-09
NCGC00091538-01
NCGC00091538-02
NCGC00091538-03
NCGC00091538-04
NCGC00091538-05
NCGC00091538-06
NSC 5105
NSC5105
PFL
Parnell Brand of Propofol
Pisa Brand of Propofol
Prestwick0_000931
Prestwick1_000931
Prestwick2_000931
Prestwick3_000931
Propofol
Propofol (JAN/USAN/INN)
Propofol Abbott
Propofol Fresenius
Propofol IDD-D
Propofol MCT
Propofol Rovi
Propofol [USAN:INN:BAN]
Propofol(2,6-Diisopropylphenol)
Propofol-Lipuro
Propofolum
Propofolum [Latin]
Rapinovet
Recofol
Rovi Brand of Propofol
S01-0189
SAM002264610
SMR000059151
SPBio_003031
SPECTRUM1505022
ST50405911
Schering Brand of Propofol
UNII-YI7VU623SF
W505102_ALDRICH
ZD-0859
ZINC00968303
Zeneca Brand of Propofol
ghl.PD_Mitscher_leg0.558
nchembio.552-comp7
propofol
3AnestheticsPhase 4, Phase 29001
4Anesthetics, IntravenousPhase 42406
5Anesthetics, GeneralPhase 4, Phase 22787
6Central Nervous System DepressantsPhase 4, Phase 212806
7Hypnotics and SedativesPhase 4, Phase 22485
8
Dexmedetomidineapproved, vet_approvedPhase 254076631-46-4, 113775-47-668602, 5311068, 56032
Synonyms:
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole
(+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole
(+)-medetomidine
(S)-medetomidine
113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole
4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
AC1NSJXT
C07450
CHEBI:4466
CHEMBL778
CID5311068
D00514
DEXMEDETOMIDINE
 
Dexdor (T)
Dexmedetomidin
Dexmedetomidina
Dexmedetomidine
Dexmedetomidine (USAN/INN)
Dexmedetomidinum
Dexmédétomidine
MPV 1440
MPV-1440
Medetomidina [Spanish]
Medetomidine
Medetomidinum [Latin]
NCGC00025347-01
PRECEDEX
Precedex (TN)
Tocris-2023
ZINC04632106
9
BenzocaineapprovedPhase 218921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
10
LevobupivacaineapprovedPhase 216527262-47-192253
Synonyms:
(-)-Bupivacaine
(-)-bupivacaine
(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(S)-1-Butyl-2',6'-pipecoloxylidide
(S)-Bupivacaine
(S)-bupivacaine
27262-47-1
27262-48-2
AC1L3NQM
BIDD:GT0471
C07887
C18H28N2O
CAS-18010-40-7
CHEBI:6149
CID92253
D08116
 
DB01002
L(-)-Bupivacaine
L-(-)-1-Butyl-2',6'-pipecoloxylidide
L-(-)-Bupivacaine
L-(-)-bupivacaine
LS-109843
LS-187025
LS-187789
Levobupivacaine
Levobupivacaine (INN)
Levobupivacaine [INN:BAN]
Levobupivacaine hydrochloride
MolPort-004-959-713
NCGC00016733-01
NCGC00159482-02
Novabupi
Novabupi (TN)
11
Bupivacaineapproved, investigationalPhase 211312180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
12tannic acidapproved, NutraceuticalPhase 21892
13Anesthetics, LocalPhase 23272
14Platelet Aggregation InhibitorsPhase 22419
15Peripheral Nervous System AgentsPhase 222776
16Neurotransmitter AgentsPhase 217734
17Adrenergic AgentsPhase 25140
18NarcoticsPhase 23486
19Anesthetics, InhalationPhase 2649
20Adrenergic alpha-2 Receptor AgonistsPhase 2911
21Adrenergic AgonistsPhase 22877
22Analgesics, Non-NarcoticPhase 26260
23AnalgesicsPhase 211287
24Adrenergic alpha-AgonistsPhase 21625
25
Dexamethasoneapproved, investigational, vet_approved208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
26
Ropivacaineapproved74184057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
27Hormones13979
28Hormones, Hormone Substitutes, and Hormone Antagonists12767
29Androgens1275
30Hormone Antagonists12778
31Estrogens2470
32glucocorticoids4920
33HIV Protease Inhibitors5319
34
protease inhibitors5320
Synonyms:
 
protease inhibitors
35Antiemetics3888
36Gastrointestinal Agents8109
37Dexamethasone acetate20841177-87-3
38Autonomic Agents9774
39BB 11012084
40Anti-Inflammatory Agents10355
41Dexamethasone 21-phosphate2084
42Antineoplastic Agents, Hormonal5407

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1The Effect of Induction Technique on Postoperative Pain and AgitationCompletedNCT02110745Phase 4
2Comparing Oxygen Saturation in Post Anesthesia Care Unit After Different Methods of Pain ReliefCompletedNCT00435383Phase 2
3Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in ChildrenCompletedNCT01701778Phase 2
4The Incidence of Congenital Undescended Testis Among Dutch InfantsUnknown statusNCT00264121
5Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenUnknown statusNCT00150163
6Cryptorchidism: Impact of in Utero Exposure to Xenobiotics With Hormonal ActionCompletedNCT00565513
7A Novel Technique of Circumcision Incision OrchidopexyCompletedNCT02249637
8Long-Term Outcome in Congenital Undescended Testis After Surgical Treatment by OrchidopexyCompletedNCT00253253
9Comparison of Dexamethasone Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia in Children Undergoing OrchiopexyCompletedNCT01604915
10Can the Hypertrophy of Contralateral Testis Predict the Absence of the Non-palpable Testis in the Boys Aged From 6months to 18months of Age ?CompletedNCT02203318
11Visual Guidelines and Tutoring in Pediatric Urological SurgeryCompletedNCT02040389
12The Caudal Space in Children: Ultrasound EvaluationCompletedNCT01896076
13A Case-Control Study of Testicular Germ Cell Tumors Among U.S. Military ServicemenCompletedNCT00341588
14Genetics of Familial Testicular CancerCompletedNCT00342537
15Orchidopexy Randomized Clinical AssessmentRecruitingNCT02235623
16Expertise-Based Randomized Controlled Trial of Scrotal Versus Inguinal Orchidopexy on Post-operative PainRecruitingNCT02158780
17DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or SiblingsRecruitingNCT01434355
18The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome)RecruitingNCT01601171
19Comparison Between the Clinical Assessment of the Undescended Testis and Its' Ultrasonographic SizeNot yet recruitingNCT02731989
20One Stage vs. Two Stage Gubernaculum Sparing Laparoscopic Orchidopexy: A Randomized Controlled TrialNot yet recruitingNCT02936024

Search NIH Clinical Center for Cryptorchidism

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: cryptorchidism

Genetic Tests for Cryptorchidism

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Genetic tests related to Cryptorchidism:

id Genetic test Affiliating Genes
1 Cryptorchidism, Unilateral or Bilateral27
2 Cryptorchidism27

Anatomical Context for Cryptorchidism

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MalaCards organs/tissues related to Cryptorchidism:

36
Testis, Testes, Pituitary, Breast, Placenta, Heart, Prostate

Publications for Cryptorchidism

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Articles related to Cryptorchidism:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Commentary to 'Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism'. (27346070)
2016
2
Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. (27769252)
2016
3
Prenatal diagnosis of cryptorchid testicular teratoma. (27081226)
2016
4
Consequences of bilateral cryptorchidism in adults. (26762811)
2016
5
Idiopathic abdominal cocoon syndrome with unilateral abdominal cryptorchidism and greater omentum hypoplasia in a young case of small bowel obstruction. (27239122)
2016
6
Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias. (26602963)
2016
7
Association between two single nucleotide polymorphisms of interleukin-27 gene and increased cryptorchidism risk. (25988814)
2016
8
Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty. (27561106)
2016
9
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. (27510681)
2016
10
Re: Hormonal Therapy Using Gonadotropin Releasing Hormone for Improvement of Fertility Index among Children with Cryptorchidism: AA Meta-Analysis and Systematic Review. (27628840)
2016
11
Molecular mechanisms of cryptorchidism development: update of the database, disease comorbidity, and initiative for standardization of reporting in scientific literature. (27370962)
2016
12
A Rare Association of Obesity, Diabetes Mellitus and Bilateral Cryptorchidism: Prader - Willi Syndrome. (27805351)
2016
13
TESTICULAR GROWTH DURING PUBERTY IN BOYS WITH AND WITHOUT A HISTORY OF CONGENITAL CRYPTORCHIDISM. (27049351)
2016
14
Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism. (26840636)
2016
15
Mixed Germ Cell Tumour in an Infertile Male Having Unilateral Cryptorchidism: A Rare Case Report. (27042527)
2016
16
Gonadal response after a single-dose stimulation test with recombinant human chorionic gonadotropin (rhCG) in patients with isolated prepubertal cryptorchidism. (27800162)
2016
17
Response to commentary to 'Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism'. (27321558)
2016
18
Proximally Directed Double-looped Epididymis and Vas Deferens Simulating Vas Duplication: The Importance of Precise Definition of Abnormal Ductal Anatomy in Cryptorchidism. (27397099)
2016
19
Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation. (28053620)
2016
20
The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism. (27614808)
2016
21
Can Hypertrophy of the Contralateral Testis Predict the Absence of a Viable Testis in Infancy with Cryptorchidism: A Prospective Analysis. (26990979)
2016
22
The Sertoli cell hormones inhibin-B and anti MA1llerian hormone have different patterns of secretion in prepubertal cryptorchid boys. (26452703)
2016
23
Computed Tomographic Features in a Case of Bilateral Neoplastic Cryptorchidism with Suspected Torsion in a Dog. (27200365)
2016
24
Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism. (27503122)
2016
25
Acquired cryptorchidism: More harm than thought? (27318547)
2016
26
A allele of SNP12 in estrogen receptor 1 was a risk factor for cryptorchidism in Asians: a systematic review with meta-analysis and trial sequential analysis. (27376826)
2016
27
Corrigendum: Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism. (27633184)
2016
28
Genetic Association Between IL-21 Polymorphisms and Cryptorchidism in a Chinese Han Population. (26990619)
2016
29
The Effectiveness of hCG and LHRH in Boys with Cryptorchidism: A Meta-Analysis of Randomized Controlled Trials. (27050251)
2016
30
Cryptorchidism: An Update. (27723902)
2016
31
Pantaloon Hernia: Obstructed Indirect Component and Direct Component with Cryptorchidism. (27579208)
2016
32
A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism. (26898822)
2016
33
Genetic, Maternal, and Environmental Risk Factors for Cryptorchidism: An Update. (27642851)
2016
34
Opinion: Comment on Evaluation and Treatment of Cryptorchidism: AUA/AAP and Nordic Consensus Guidelines. (26824668)
2016
35
Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism. (27321556)
2016
36
Feasibility and Efficacy of a Urologic Profession Campaign on Cryptorchidism Using Internet and Social Media. (27806367)
2016
37
Post-fertilization effect of bilateral primary testicular damage induced by unilateral cryptorchidism in the rat model. (26757429)
2016
38
Influence of naturally unilateral cryptorchidism on the histomorphometry of the testes and daily sperm production in West African Dwarf goats. (27656223)
2016
39
Cryptorchidism and pesticides: Is there a connection? (27956069)
2016
40
Positive Oct -3/4 and D2-40 Immunohistochemical Expression in Germ Cells and Suspected Histology Pattern of Intratubular Germ Cell Neoplasia in Boys with Cryptorchidism Vanish after the Age of 2 Years. (27606906)
2016
41
The functional and predictive roles of miR-210 in cryptorchidism. (27562222)
2016
42
Hormonal Aspects of the Pathogenesis and Treatment of Cryptorchidism. (27642852)
2016
43
Long-Term Follow-Up after Treatment of Cryptorchidism. (27589079)
2016
44
Mutational analysis of HOXA10 gene in Chinese patients with cryptorchidism. (27108669)
2016
45
A Case of Cryptorchidism with Ipsilateral Congenital Unilateral Absence of the Vas Deferens and Contralateral Renal Agenesis. (27597925)
2016
46
Laparoscopic treatment for inguinal hernia combined with cryptorchidism: Totally extraperitoneal repair with orchiectomy under the same operative view. (26581081)
2015
47
Evaluation and management of the infant with cryptorchidism. (26087417)
2015
48
Operative management of cryptorchidism: guidelines and reality--a 10-year observational analysis of 3587 cases. (26357871)
2015
49
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. (25970213)
2015
50
Malignant seminoma in two unilaterally cryptorchid stallions. (25759202)
2015

Variations for Cryptorchidism

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UniProtKB/Swiss-Prot genetic disease variations for Cryptorchidism:

70
id Symbol AA change Variation ID SNP ID
1INSL3p.Pro93LeuVAR_013235rs104894697
2INSL3p.Arg102CysVAR_013236rs104894698
3INSL3p.Asn110LysVAR_017122rs121912555
4RXFP2p.Thr222ProVAR_015386rs28939382

Clinvar genetic disease variations for Cryptorchidism:

5
id Gene Variation Type Significance SNP ID Assembly Location
1INSL3NM_005543.3(INSL3): c.330C> G (p.Asn110Lys)SNVPathogenicrs121912555GRCh37Chr 19, 17927729: 17927729
2INSL3NM_005543.3(INSL3): c.278C> T (p.Pro93Leu)SNVPathogenicrs104894697GRCh37Chr 19, 17927781: 17927781
3INSL3NM_005543.3(INSL3): c.304C> T (p.Arg102Cys)SNVPathogenicrs104894698GRCh37Chr 19, 17927755: 17927755
4INSL3NM_005543.3(INSL3): c.305G> A (p.Arg102His)SNVPathogenicrs121912556GRCh37Chr 19, 17927754: 17927754
546;XY;t(5;15)(q11.2;q24)TranslocationPathogenicChr na, -1: -1
646;XY;t(6: 11)(p12.3;p14.2)dnTranslocationPathogenicChr na, -1: -1
7INSL3NM_005543.3(INSL3): c.217C> T (p.Arg73Ter)SNVPathogenicrs398122886GRCh37Chr 19, 17927842: 17927842

Copy number variations for Cryptorchidism from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
14506810670000012300000GainCryptorchidism
26227812107500000132349534GainCryptorchidism
389249151700000023300000LossCryptorchidism
42024475820000015100000GainCryptorchidism
5260236X146900000154913754GainCryptorchidism
6266753Y157772954MicrodeletionCryptorchidism

Expression for genes affiliated with Cryptorchidism

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Search GEO for disease gene expression data for Cryptorchidism.

Pathways for genes affiliated with Cryptorchidism

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GO Terms for genes affiliated with Cryptorchidism

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Cellular components related to Cryptorchidism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.9AMH, CGA, CGB5, FGFR1, GNRH1, IGFL3

Biological processes related to Cryptorchidism according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1oocyte maturationGO:000155610.8INSL3, RXFP2
2hormone metabolic processGO:004244510.7NR5A1, PTPN11
3multicellular organism growthGO:003526410.6AR, PTPN11, SOS1
4neurotrophin TRK receptor signaling pathwayGO:004801110.5PTPN11, RAF1, SOS1
5male gonad developmentGO:000858410.4AR, HOXA10, INSL3, NR5A1, RXFP2
6cell-cell signalingGO:000726710.2AMH, AR, CGA, GNRH1, INSL3, NR5A1
7negative regulation of cell proliferationGO:000828510.0AR, GNRH1, INSL3, LBX1, RAF1, RXFP2
8regulation of gene expressionGO:00104689.8AR, FGFR1, GNRH1, HOXA10

Molecular functions related to Cryptorchidism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen bindingGO:000549710.6AR, SHBG
2hormone activityGO:00051799.8AMH, CGA, GNRH1, INSL3

Sources for Cryptorchidism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet