MCID: CRY035
MIFTS: 58

Cryptorchidism, Unilateral or Bilateral

Categories: Genetic diseases, Reproductive diseases

Aliases & Classifications for Cryptorchidism, Unilateral or Bilateral

MalaCards integrated aliases for Cryptorchidism, Unilateral or Bilateral:

Name: Cryptorchidism, Unilateral or Bilateral 53 28
Cryptorchidism 53 12 71 28 13 51 41 14
Undescended Testis 53 12
Impaired Testicular Descent 71
Undescended Testicles 12
Undescended Testicle 12
Cryptosporidiosis 69
Cryptorchism 12
Crypto 71

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
mutations are frequently maternally inherited


HPO:

31
cryptorchidism, unilateral or bilateral:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 219050
Disease Ontology 12 DOID:11383
ICD9CM 34 752.51
MeSH 41 D003456
NCIt 46 C12326
MedGen 39 C0010417
SNOMED-CT via HPO 65 263681008 204942005 268227001
UMLS 69 C0010417

Summaries for Cryptorchidism, Unilateral or Bilateral

OMIM : 53 Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002). (219050)

MalaCards based summary : Cryptorchidism, Unilateral or Bilateral, also known as cryptorchidism, is related to persistent mullerian duct syndrome and kallmann syndrome, and has symptoms including renal agenesis, unilateral cryptorchidism and pruritus. An important gene associated with Cryptorchidism, Unilateral or Bilateral is INSL3 (Insulin Like 3), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Hormone ligand-binding receptors. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include testis and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

UniProtKB/Swiss-Prot : 71 Cryptorchidism: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Wikipedia : 72 Cryptorchidism is the absence of one or both testes from the scrotum. The word is from the Greek... more...

Related Diseases for Cryptorchidism, Unilateral or Bilateral

Diseases related to Cryptorchidism, Unilateral or Bilateral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 persistent mullerian duct syndrome 32.4 AMH INSL3 NR5A1 WT1
2 kallmann syndrome 32.0 CGA FGFR1 GNRH1 INSL3 NR5A1 STS
3 hypospadias 30.9 AR INSL3 NR5A1 WT1
4 malignant germ cell tumor 30.6 AR CGA
5 infertility 30.6 CYP19A1 DAZ1 GNRH1 INSL3 NR5A1 RXFP2
6 testicular cancer 30.3 AR AZF1 CGA INSL3 RXFP2 SHBG
7 malignant tumor of undescended testis 12.4
8 torticollis, keloids, cryptorchidism, and renal dysplasia 12.1
9 anophthalmia esophageal atresia cryptorchidism 11.9
10 intellectual disability-hypotonia-brachycephaly-pyloric stenosis-cryptorchidism syndrome 11.9
11 spigelian hernia-cryptorchidism syndrome 11.9
12 prune belly syndrome 11.8
13 cryptosporidiosis 11.7
14 mcdonough syndrome 11.6
15 ifap syndrome with or without bresheck syndrome 11.5
16 fetal akinesia deformation sequence 11.4
17 testicular germ cell tumor 11.4
18 caudal appendage deafness 11.4
19 filippi syndrome 11.2
20 van benthem-driessen-hanveld syndrome 11.1
21 ritscher-schinzel syndrome 1 11.1
22 culler-jones syndrome 11.1
23 hypogonadotropic hypogonadism 11.0
24 prader-willi syndrome 11.0
25 47, xxy 10.6 AR SHBG
26 46,xy partial gonadal dysgenesis 10.6 NR5A1 WT1
27 freemartinism 10.6 AMH GNRH1
28 physical disorder 10.6 AMH INSL3 RXFP2
29 hypoactive sexual desire disorder 10.6 CYP19A1 SHBG
30 postmenopausal atrophic vaginitis 10.6 AR SHBG
31 frasier syndrome 10.6 AMH NR5A1 WT1
32 penis agenesis 10.6 AR CGA GNRH1
33 oocyte maturation defect 1 10.6 CGA CYP19A1
34 nodular prostate 10.6 AR GNRH1
35 androgen insensitivity, partial 10.6 AR CYP19A1 SHBG
36 gonadal dysgenesis 10.6 AMH NR5A1 WT1
37 sex cord-gonadal stromal tumor 10.6 CYP19A1 NR5A1 WT1
38 androgenic alopecia 10.6 AR CYP19A1 SHBG
39 46 xy gonadal dysgenesis 10.6 NR5A1 SHBG WT1
40 anorchia 10.6 CGA INSL3 NR5A1 RXFP2
41 amenorrhea 10.6 GNRH1 NR5A1 SHBG
42 testicular disease 10.6 CGA IGFL3 INSL3
43 male reproductive organ cancer 10.6 AR GNRH1 SHBG
44 hyperandrogenism 10.6 CYP19A1 GNRH1 SHBG
45 luteoma 10.6 CGA CYP19A1
46 prostatic adenoma 10.5 AR SHBG
47 pseudohermaphroditism 10.5 AMH AR CYP19A1 WT1
48 transsexualism 10.5 AR CYP19A1
49 alopecia, androgenetic, 1 10.5 AR CYP19A1 SHBG STS
50 ovarian hyperstimulation syndrome 10.5 AMH CGA CYP19A1 GNRH1

Graphical network of the top 20 diseases related to Cryptorchidism, Unilateral or Bilateral:



Diseases related to Cryptorchidism, Unilateral or Bilateral

Symptoms & Phenotypes for Cryptorchidism, Unilateral or Bilateral

Symptoms via clinical synopsis from OMIM:

53
Genitourinary Internal Genitalia Male:
cryptorchidism, unilateral or bilateral
oligozoospermia, mild (in some patients)
normozoospermia (in some patients)


Clinical features from OMIM:

219050

Human phenotypes related to Cryptorchidism, Unilateral or Bilateral:

31
# Description HPO Frequency HPO Source Accession
1 renal agenesis 31 HP:0000104
2 unilateral cryptorchidism 31 HP:0012741

UMLS symptoms related to Cryptorchidism, Unilateral or Bilateral:


pruritus, fever

MGI Mouse Phenotypes related to Cryptorchidism, Unilateral or Bilateral:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 AMH AR CGA CYP19A1 FGFR1 GNRH1
2 growth/size/body region MP:0005378 9.7 HOXA10 LBX1 NR5A1 RXFP2 WT1 ANKRD11
3 reproductive system MP:0005389 9.44 CGA CIRBP CYP19A1 FGFR1 GNRH1 HOXA10

Drugs & Therapeutics for Cryptorchidism, Unilateral or Bilateral

Drugs for Cryptorchidism, Unilateral or Bilateral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206
3 Anesthetics Phase 4,Phase 2
4 Anesthetics, General Phase 4,Phase 2
5 Anesthetics, Intravenous Phase 4
6 Central Nervous System Depressants Phase 4,Phase 2
7 Hypnotics and Sedatives Phase 4,Phase 2
8
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
9
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
10
Dexmedetomidine Approved, Vet_approved Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
11
Levobupivacaine Approved, Investigational Phase 2 27262-47-1 92253
12 tannic acid Approved, Nutraceutical Phase 2
13 Narcotics Phase 2
14 Adrenergic Agents Phase 2
15 Adrenergic Agonists Phase 2
16 Adrenergic alpha-2 Receptor Agonists Phase 2
17 Adrenergic alpha-Agonists Phase 2
18 Analgesics Phase 2
19 Analgesics, Non-Narcotic Phase 2
20 Anesthetics, Inhalation Phase 2
21 Anesthetics, Local Phase 2
22 Neurotransmitter Agents Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Platelet Aggregation Inhibitors Phase 2
25
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
26
Ropivacaine Approved 84057-95-4 175805 71273
27
Acetaminophen Approved 103-90-2 1983
28
Ketorolac Approved 74103-06-3, 66635-83-4 3826
29
Morphine Approved, Investigational 57-27-2 5288826
30
Ondansetron Approved 99614-02-5 4595
31
Remifentanil Approved 132875-61-7 60815
32 Androgens
33 Estrogens
34 Hormone Antagonists
35 Hormones
36 Hormones, Hormone Substitutes, and Hormone Antagonists
37 Antiemetics
38 Anti-Inflammatory Agents
39 Antineoplastic Agents, Hormonal
40 Autonomic Agents
41 BB 1101
42 Dexamethasone acetate 1177-87-3
43 Gastrointestinal Agents
44 glucocorticoids
45 HIV Protease Inhibitors
46
protease inhibitors
47 Analgesics, Opioid
48 Anti-Anxiety Agents
49 Anti-Inflammatory Agents, Non-Steroidal
50 Antipruritics

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 The Effect of Induction Technique on Postoperative Pain and Agitation Completed NCT02110745 Phase 4 Sevofluorane;Propofol
2 Comparing Oxygen Saturation in Post Anesthesia Care Unit After Different Methods of Pain Relief Completed NCT00435383 Phase 2
3 Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children Completed NCT01701778 Phase 2 Caudal Dexmedetomidine;Intravenous Dexmedetomidine;Placebo;sevoflurane
4 The Incidence of Congenital Undescended Testis Among Dutch Infants Unknown status NCT00264121
5 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
6 Cryptorchidism: Impact of in Utero Exposure to Xenobiotics With Hormonal Action Completed NCT00565513
7 Long-Term Outcome in Congenital Undescended Testis After Surgical Treatment by Orchidopexy Completed NCT00253253
8 A Novel Technique of Circumcision Incision Orchidopexy Completed NCT02249637
9 Comparison of Dexamethasone Added to Ropivacaine and Ropivacaine Alone in Caudal Analgesia in Children Undergoing Orchiopexy Completed NCT01604915
10 Can the Hypertrophy of Contralateral Testis Predict the Absence of the Non-palpable Testis in the Boys Aged From 6months to 18months of Age ? Completed NCT02203318
11 Visual Guidelines and Tutoring in Pediatric Urological Surgery Completed NCT02040389
12 The Caudal Space in Children: Ultrasound Evaluation Completed NCT01896076
13 A Case-Control Study of Testicular Germ Cell Tumors Among U.S. Military Servicemen Completed NCT00341588
14 Genetics of Familial Testicular Cancer Completed NCT00342537
15 Comparison Between the Clinical Assessment of the Undescended Testis and Its' Ultrasonographic Size Recruiting NCT02731989
16 Orchidopexy Randomized Clinical Assessment Recruiting NCT02235623
17 One Stage vs. Two Stage Gubernaculum Sparing Laparoscopic Orchidopexy (GSLO) Recruiting NCT02936024
18 Expertise-Based Randomized Controlled Trial of Scrotal Versus Inguinal Orchidopexy on Post-operative Pain Recruiting NCT02158780
19 Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair Recruiting NCT03041935 Acetaminophen;Sevoflurane;Remifentanil;Propofol;Morphine;Ondansetron;Dexamethasone;Ketorolac;Ropivacaine
20 Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort Recruiting NCT03084445
21 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
22 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171
23 Impact of Percutaneous Laparoscopic Assisted Internal Ring Ligation During Lap Orchiopexy Not yet recruiting NCT03291678

Search NIH Clinical Center for Cryptorchidism, Unilateral or Bilateral

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: cryptorchidism

Genetic Tests for Cryptorchidism, Unilateral or Bilateral

Genetic tests related to Cryptorchidism, Unilateral or Bilateral:

# Genetic test Affiliating Genes
1 Cryptorchidism, Unilateral or Bilateral 28 INSL3 RXFP2
2 Cryptorchidism 28

Anatomical Context for Cryptorchidism, Unilateral or Bilateral

MalaCards organs/tissues related to Cryptorchidism, Unilateral or Bilateral:

38
Testis, Testes

Publications for Cryptorchidism, Unilateral or Bilateral

Articles related to Cryptorchidism, Unilateral or Bilateral:

(show top 50) (show all 766)
# Title Authors Year
1
Testicular Torsion in an Infant with Undescended Testis. ( 29429568 )
2018
2
Testicular torsion in undescended testis: A persistent challenge. ( 29264215 )
2017
3
Single nucleotide polymorphisms associated with nonsyndromic cryptorchidism in Mexican patients. ( 28295519 )
2017
4
Seminoma in Undescended Testis Presenting as Metastatic Enlarged Cervical Lymph Nodes. ( 29132494 )
2017
5
A Case-Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations. ( 28557710 )
2017
6
Scrotal testis size in unilateral non-palpable cryptorchidism, what it can and cannot tell: Study of a Middle Eastern population. ( 28254240 )
2017
7
Pediatric urologists must advocate for improved quality of care in patients with cryptorchidism. ( 28265314 )
2017
8
Genetic analysis of HOXA11 gene in Chinese patients with cryptorchidism. ( 28261830 )
2017
9
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice. ( 28771045 )
2017
10
Copy number variants of Ras/MAPK pathway genes in patients with isolated cryptorchidism. ( 28914499 )
2017
11
Cryptorchidism: experience and reason. ( 28832317 )
2017
12
Analgesia use during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis. ( 28333256 )
2017
13
Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism. ( 28761584 )
2017
14
Health Disparities in the Appropriate Management of Cryptorchidism. ( 28408128 )
2017
15
A population-based study of prevalence trends and geospatial analysis of hypospadias and cryptorchidism compared with non-endocrine mediated congenital anomalies. ( 28351651 )
2017
16
Vascular Ehlers-Danlos syndrome with cryptorchidism, recurrent pneumothorax, and pulmonary capillary hemangiomatosis-like foci: A case report. ( 29381997 )
2017
17
Exomic and Epigenomic Analyses in a Pair of Monozygotic Twins Discordant for Cryptorchidism. ( 28606200 )
2017
18
Risk factors for cryptorchidism. ( 28654092 )
2017
19
Cryptorchidism: A practical review for all community healthcare providers. ( 28265313 )
2017
20
Paediatric Urology and the Dilemma of Low-quality Evidence for the Management of Common Urological Conditions (Vesicoureteral Reflux, Lower Urinary Tract Dysfunction, Undescended Testis) in Children. ( 28753880 )
2017
21
First reported case of paratesticular seminoma in a postpubertal cryptorchid testis. ( 28698791 )
2017
22
Rural versus urban compliance in the management of cryptorchidism: is there a difference? ( 28639144 )
2017
23
Bloating due to massive seminoma in an undescended testis. ( 28944978 )
2017
24
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
25
Gonadal response after a single-dose stimulation test with recombinant human chorionic gonadotropin (rhCG) in patients with isolated prepubertal cryptorchidism. ( 27800162 )
2016
26
Mutational analysis of HOXA10 gene in Chinese patients with cryptorchidism. ( 27108669 )
2016
27
The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism. ( 27614808 )
2016
28
A allele of SNP12 in estrogen receptor 1 was a risk factor for cryptorchidism in Asians: a systematic review with meta-analysis and trial sequential analysis. ( 27376826 )
2016
29
Long-Term Follow-Up after Treatment of Cryptorchidism. ( 27589079 )
2016
30
Mutational screening of the INSL3 gene in azoospermic males with a history of cryptorchidism. ( 26840636 )
2016
31
Pantaloon Hernia: Obstructed Indirect Component and Direct Component with Cryptorchidism. ( 27579208 )
2016
32
Corrigendum: Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism. ( 27633184 )
2016
33
Genomic copy number variation association study in Caucasian patients with nonsyndromic cryptorchidism. ( 27769252 )
2016
34
Hormonal Aspects of the Pathogenesis and Treatment of Cryptorchidism. ( 27642852 )
2016
35
Feasibility and Efficacy of a Urologic Profession Campaign on Cryptorchidism Using Internet and Social Media. ( 27806367 )
2016
36
A Rare Association of Obesity, Diabetes Mellitus and Bilateral Cryptorchidism: Prader - Willi Syndrome. ( 27805351 )
2016
37
Congenital Erythropoietic Porphyria with Undescended Testis. ( 27512208 )
2016
38
A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism. ( 26898822 )
2016
39
Genetic Association Between IL-21 Polymorphisms and Cryptorchidism in a Chinese Han Population. ( 26990619 )
2016
40
Consequences of bilateral cryptorchidism in adults. ( 26762811 )
2016
41
Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty. ( 27561106 )
2016
42
Response to commentary to 'Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism'. ( 27321558 )
2016
43
Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias. ( 26602963 )
2016
44
Idiopathic abdominal cocoon syndrome with unilateral abdominal cryptorchidism and greater omentum hypoplasia in a young case of small bowel obstruction. ( 27239122 )
2016
45
Influence of naturally unilateral cryptorchidism on the histomorphometry of the testes and daily sperm production in West African Dwarf goats. ( 27656223 )
2016
46
Cryptorchidism: An Update. ( 27723902 )
2016
47
A Case of Cryptorchidism with Ipsilateral Congenital Unilateral Absence of the Vas Deferens and Contralateral Renal Agenesis. ( 27597925 )
2016
48
Proximally Directed Double-looped Epididymis and Vas Deferens Simulating Vas Duplication: The Importance of Precise Definition of Abnormal Ductal Anatomy in Cryptorchidism. ( 27397099 )
2016
49
Re: Hormonal Therapy Using Gonadotropin Releasing Hormone for Improvement of Fertility Index among Children with Cryptorchidism: AA Meta-Analysis and Systematic Review. ( 27628840 )
2016
50
Bilateral Cryptorchidism, a rare presentation for persistent MA1llerian duct syndrome. ( 28163853 )
2016

Variations for Cryptorchidism, Unilateral or Bilateral

UniProtKB/Swiss-Prot genetic disease variations for Cryptorchidism, Unilateral or Bilateral:

71
# Symbol AA change Variation ID SNP ID
1 INSL3 p.Pro93Leu VAR_013235 rs104894697
2 INSL3 p.Arg102Cys VAR_013236 rs104894698
3 INSL3 p.Asn110Lys VAR_017122 rs121912555
4 RXFP2 p.Thr222Pro VAR_015386 rs121918303

ClinVar genetic disease variations for Cryptorchidism, Unilateral or Bilateral:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 INSL3 NM_005543.3(INSL3): c.330C> G (p.Asn110Lys) single nucleotide variant Pathogenic rs121912555 GRCh37 Chromosome 19, 17927729: 17927729
2 INSL3 NM_005543.3(INSL3): c.278C> T (p.Pro93Leu) single nucleotide variant Pathogenic rs104894697 GRCh37 Chromosome 19, 17927781: 17927781
3 INSL3 NM_005543.3(INSL3): c.304C> T (p.Arg102Cys) single nucleotide variant Pathogenic rs104894698 GRCh37 Chromosome 19, 17927755: 17927755
4 INSL3 NM_005543.3(INSL3): c.305G> A (p.Arg102His) single nucleotide variant Pathogenic rs121912556 GRCh37 Chromosome 19, 17927754: 17927754
5 INSL3 NM_005543.3(INSL3): c.217C> T (p.Arg73Ter) single nucleotide variant Pathogenic rs398122886 GRCh37 Chromosome 19, 17927842: 17927842
6 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633
7 SMCHD1 NM_015295.2(SMCHD1): c.511T> G (p.Phe171Val) single nucleotide variant Pathogenic rs1135402740 GRCh38 Chromosome 18, 2674018: 2674018

Copy number variations for Cryptorchidism, Unilateral or Bilateral from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 45068 10 6700000 12300000 Gain Cryptorchidism
2 62278 12 107500000 132349534 Gain Cryptorchidism
3 89249 15 17000000 23300000 Loss Cryptorchidism
4 202447 5 8200000 15100000 Gain Cryptorchidism
5 260236 X 146900000 154913754 Gain Cryptorchidism
6 266753 Y 1 57772954 Microdeletion Cryptorchidism

Expression for Cryptorchidism, Unilateral or Bilateral

Search GEO for disease gene expression data for Cryptorchidism, Unilateral or Bilateral.

Pathways for Cryptorchidism, Unilateral or Bilateral

Pathways related to Cryptorchidism, Unilateral or Bilateral according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 AR CGA CYP19A1
2 10.37 CGA GNRH1
3 10.05 AR GNRH1 SHBG
4 9.85 CYP19A1 STS

GO Terms for Cryptorchidism, Unilateral or Bilateral

Biological processes related to Cryptorchidism, Unilateral or Bilateral according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.85 AR GNRH1 LBX1 RXFP2 WT1
2 regulation of gene expression GO:0010468 9.73 AR FGFR1 GNRH1 HOXA10
3 cell-cell signaling GO:0007267 9.63 AMH AR CGA GNRH1 INSL3 NR5A1
4 adrenal gland development GO:0030325 9.51 NR5A1 WT1
5 tissue development GO:0009888 9.49 NR5A1 WT1
6 uterus development GO:0060065 9.48 CYP19A1 HOXA10
7 gonad development GO:0008406 9.43 AMH CGA WT1
8 positive regulation of male gonad development GO:2000020 9.4 NR5A1 WT1
9 prostate gland growth GO:0060736 9.37 AR CYP19A1
10 negative regulation of female gonad development GO:2000195 9.32 NR5A1 WT1
11 sex determination GO:0007530 9.13 AMH NR5A1 WT1
12 male gonad development GO:0008584 9.02 AR HOXA10 NR5A1 RXFP2 WT1

Molecular functions related to Cryptorchidism, Unilateral or Bilateral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 AR HOXA10 LBX1 NR5A1 WT1
2 androgen binding GO:0005497 8.96 AR SHBG
3 hormone activity GO:0005179 8.92 AMH CGA GNRH1 INSL3

Sources for Cryptorchidism, Unilateral or Bilateral

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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