MCID: CRY003
MIFTS: 60

Cryptosporidiosis malady

Infectious diseases, Gastrointestinal diseases categories

Summaries for Cryptosporidiosis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to diarrhea and microsporidiosis. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Cytokines and Inflammatory Response and Rho Family GTPases. The drug nitazoxanide and the compounds hydrocortisone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:63 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 8 42 10 44 48 33 60
cryptosporidial gastroenteritis 8 60
infection by cryptosporidium 8
intestinal cryptosporidiosis 8


External Ids:

Disease Ontology8 DOID:1733
ICD9CM27 007.4
MeSH34 D003457
MESH via Orphanet35 D003457
ICD10 via Orphanet26 A07.2
SNOMED-CT via Orphanet57 240370009, 58777003
UMLS via Orphanet61 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.6TAC1, CD79A, CD4, LTF, SST, VIP
2microsporidiosis30.5CD4
3acquired immunodeficiency syndrome30.3DHFR, CD4
4toxoplasmosis30.1DHFR, CD79A, CD40LG, CD4
5pancreatitis30.0TAC1, LTF, SST
6graft versus host disease30.0IL4, CSF3, CCL5
7hepatitis30.0CXCL10, CD40LG, CD4, CAT, CCL11
8adenocarcinoma30.0TAC1, CXCL10, SST, CCL5, VIP
9crohn's disease29.8LTF
10ankylosing spondylitis29.8CD79A
11conjunctivitis29.8CD79A
12cd40 ligand deficiency29.8CD40LG
13acute leukemia29.8DHFR, CSF3
14colorectal cancer29.8DHFR, CD4, LTF
15pneumocystosis29.8DHFR, CD4
16candidiasis29.8CD79A, CD4, LTF
17pancreatic cancer29.8SST, VIP
18hepatitis c29.8IL4, CXCL10, CD40LG, LTF
19rhinitis29.8TAC1, IL4, CD79A, CCL5, CCL11, VIP
20gastritis29.8CD79A, CD4, LTF, SST, CAT, CCL5
21ulcerative colitis29.8SLC15A1, TAC1, IL1A, IL4, CXCL10, CD79A
22leukemia29.7IL1A, IL4, DHFR, CD79A, CD40LG, CD4
23giardiasis10.5
24sclerosing cholangitis10.2
25cholangitis10.2
26acute diarrhea10.1
27cyclosporiasis10.1
28coccidiosis10.1
29gastroenteritis10.1
30hepatitis a10.0
31cholangiocarcinoma10.0
32intestinal disease10.0
33mouth disease10.0
34kawasaki disease10.0MBL2
35rheumatic fever10.0MBL2
36keratoconjunctivitis10.0CCL11
37stomach cancer10.0MBL2
38dementia10.0CXCL10
39paracoccidioidomycosis10.0CXCL10
40neuritis10.0CCL5
41complex regional pain syndrome10.0TAC1
42schizophrenia10.0TAC1
43parkinson's disease10.0TAC1
44biliary atresia10.0CXCL10
45glioblastoma multiforme10.0TAC1
46severe acute respiratory syndrome10.0CXCL10
47sudden infant death syndrome10.0TAC1
48periodontitis10.0IL1A
49fanconi's anemia10.0DHFR
50keratoconjunctivitis sicca10.0LTF

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Clinical Features for Cryptosporidiosis

About this section

Drugs & Therapeutics for Cryptosporidiosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Search CenterWatch for Cryptosporidiosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cryptosporidiosis

About this section

Anatomical Context for Cryptosporidiosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cryptosporidiosis:

32
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cryptosporidiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9TAC1
2MP:00053977.2CCL11, CCL5, MBL2, CSF3, LTF, CD4
3MP:00053876.4IL1A, VIP, CCL11, CCL5, MBL2, CSF3
4MP:00053765.9LTF, SST, MBL2, CAT, VIP, CD4

Publications for Cryptosporidiosis

About this section
Sources:
50PubMed
See all sources

Articles related to Cryptosporidiosis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Human cryptosporidiosis caused by Cryptosporidium tyzzeri and C. parvum isolates presumably transmitted from wild mice. (23100342)
2013
2
Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study. (23243179)
2013
3
Glycoprotein 60 Diversity in Cryptosporidium parvum Causing Human and Cattle Cryptosporidiosis in the Rural Region of Northern Tunisia. (24343888)
2013
4
Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh. (22302851)
2012
5
Promotion of healthy swimming after a statewide outbreak of cryptosporidiosis associated with recreational water venues--Utah, 2008-2009. (22592274)
2012
6
Epidemiology, clinical, immune, and molecular profiles of microsporidiosis and cryptosporidiosis among HIV/AIDS patients. (22924007)
2012
7
Cryptosporidiosis: An under-recognized public health problem. (23767015)
2012
8
Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves. (21546409)
2011
9
Quantitative microbial risk assessment of cryptosporidiosis and giardiasis from very small private water supplies. (20880218)
2011
10
Cryptosporidiosis and its potential risk factors in children and calves in Babol, north of Iran. (21602778)
2011
11
Cryptosporidiosis caused by two distinct species in Russian tortoises and a pancake tortoise. (20189312)
2010
12
Cryptosporidiosis in neonatal calves. (20117545)
2010
13
Lymphocytes and not IFN-gamma mediate expression of iNOS by intestinal epithelium in murine cryptosporidiosis. (20352449)
2010
14
A hospital-based serological survey of cryptosporidiosis in the Republic of Korea. (19724694)
2009
15
Pulmonary cryptosporidiosis in HIV negative, immunocompromised host. (19332937)
2009
16
Human cryptosporidiosis: a review. (19894474)
2009
17
Multiple risk factors associated with a large statewide increase in cryptosporidiosis. (19470196)
2009
18
Investigation of the role of companion animals in the zoonotic transmission of cryptosporidiosis. (19068076)
2009
19
Treatment of cryptosporidiosis. (19400754)
2009
20
Diagnosis of cryptosporidiosis using PCR or auramine O with LED fluorescent microscopy: which end of the stick? (18822266)
2009
21
Using infectious intestinal disease surveillance data to explore illness aetiology; a cryptosporidiosis case study. (18706849)
2009
22
Effect of nitazoxanide on cryptosporidiosis in experimentally infected neonatal dairy calves. (19307646)
2009
23
Feeding activated charcoal from bark containing wood vinegar liquid (nekka-rich) is effective as treatment for cryptosporidiosis in calves. (18349239)
2008
24
A swimming pool-associated outbreak of cryptosporidiosis in Staffordshire, England, October to December 2007. (19000569)
2008
25
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. (19101474)
2008
26
Outbreak of cryptosporidiosis among veterinary students. (18587060)
2008
27
Possible involvement of Artemia as live diet in the transmission of cryptosporidiosis in cultured fish. (17468970)
2007
28
Immunochemotherapy for cryptosporidiosis in immunosuppressed mouse model. (18383794)
2007
29
Cryptosporidiosis among immunocompromised patients in Saudi Arabia. (17926813)
2007
30
Cryptosporidiosis: a recreational water threat that hasn't gone away. (17583299)
2007
31
Correlation of ELISA copro-antigen and oocysts count to the severity of cryptosporidiosis parvum in children. (17580571)
2007
32
Cryptosporidiosis: still a problem. (17717881)
2007
33
Cryptosporidiosis in children suffering from diarrhoel diseases in a hospital of Ludhiana. (18240482)
2007
34
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
35
Cryptosporidiosis among children in Tripoli. (16605104)
2006
36
Cryptosporidiosis and other intestinal protozoan infections in children less than one year of age in Mexico City. (17172373)
2006
37
The potential for acquiring cryptosporidiosis or giardiosis from consumption of mung bean sprouts in Norway: a preliminary step-wise risk assessment. (15698690)
2005
38
Cryptosporidiosis surveillance--United States 1999-2002. (15674188)
2005
39
Cryptosporidiosis and microsporidiosis in ugandan children with persistent diarrhea with and without concurrent infection with the human immunodeficiency virus. (16282304)
2005
40
Cryptosporidiosis presenting as acute appendicitis: a case report. (16044940)
2005
41
Outbreak of enteric cryptosporidiosis in cockatiels (Nymphicus hollandicus). (15747659)
2005
42
Cryptosporidiosis leading to an unsuspected diagnosis of AIDS. (15460500)
2004
43
Cryptosporidiosis of the biliary tract mimicking pancreatic cancer in an AIDS patient. (15094908)
2004
44
Endemic cryptosporidiosis and exposure to municipal tap water in persons with acquired immunodeficiency syndrome (AIDS): a case-control study. (12515584)
2003
45
Cryptosporidiosis. (12686887)
2002
46
Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children. (12089667)
2002
47
Efficacy of beta-cyclodextrin against experimental cryptosporidiosis in neonatal lambs. (12053962)
2002
48
PCR-ELISA: a new simplified tool for tracing the source of cryptosporidiosis in HIV-positive patients. (11763435)
2001
49
Contribution to the laboratory diagnosis of human cryptosporidiosis. (11340480)
2001
50
Clinical and pathological observations on natural infections of cryptosporidiosis and flagellate protozoa in leopard geckos (Eublepharis macularius). (10638796)
1999

Genetic Variations for Cryptosporidiosis

About this section

Expression for genes affiliated with Cryptosporidiosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

About this section
Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
10.0CXCL10, CD4
39.9CD79A, CD4
49.8CCL11, CCL5, CXCL10
59.7IL4, CXCL10, CCL11
69.6IL4, CD40LG, CCL11
79.2CCL5, CD4, CD79A, IL4
8
Hide members
9.1CCL11, CCL5, CD4, IL4, IL1A
9
Hide members
9.0CCL11, CD4, CD40LG, IL4, IL1A
109.0CSF3, CD4, IL4, IL1A
11
Hide members
9.0CCL11, CCL5, CSF3, CD4, CXCL10
12
Hide members
8.9IL1A, CXCL10, CD4, CSF3, CCL11
13
Hide members
8.9IL1A, IL4, CD79A, CD40LG, CD4
14
Hide members
8.8TAC1, CXCL10, SST, CCL5, CCL11
15
Hide members
8.3CXCL10, CD4, CSF3, CCL5, CCL11, IL4

Compounds for genes affiliated with Cryptosporidiosis

About this section
Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
See all sources

Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6LTF
2endotoxin4410.1CSF3, LTF
3cycloheximide449.9CXCL10, CAT, CD4
4pneumococcal449.8LTF, CD79A, CD40LG, DHFR
5glutamate449.8TAC1, CD40LG, SLC15A1
6mannan449.7CD4, MBL2, CD79A
7pmma449.6CD40LG, CD79A, CCL5, LTF
8indomethacin44 59 28 1112.6VIP, LTF, TAC1
9hemocyanin449.5CD40LG, CD79A, IL4, CD4
10lactose44 1110.5MBL2, SST, LTF, DHFR, CD40LG
11estrogen449.5CD79A, TAC1, MBL2, LTF
12norepinephrine44 11 2411.5VIP, TAC1, LTF
13polymyxin b449.4MBL2, IL4, IL1A, LTF
14allergens449.4IL4, CXCL10, CD79A, CD40LG, CCL11
15ccl344 2810.3IL1A, CCL5, CSF3, CCL11, CXCL10
16n-formylmethionyl-leucylphenylalanine449.3CCL11, CSF3, IL1A, LTF, SLC15A1
17pertussis449.3SST, CCL5, LTF, CCL11, VIP
18tarc449.3IL1A, IL4, CXCL10, CD4, CCL5, CCL11
19chloroquine44 2 49 28 1113.2CD4, IL4, CXCL10, DHFR, CD79A
20isoproterenol44 1110.2IL1A, TAC1, LTF, SST
21pge2449.2PTGES3, CD4, CCL11, SST
22anti-fungal449.1MBL2, CSF3, LTF, CD40LG, CD79A, DHFR
23ribavirin44 49 1111.1CSF3, MBL2, LTF, CXCL10, IL4, CD40LG
24leukotriene b444 59 2411.0CCL11, CCL5, LTF, IL1A, CXCL10
25cyclophosphamide44 49 1110.9TAC1, DHFR, SST, CSF3, MBL2
26polyethylene glycol448.9IL4, CD79A, VIP, CD40LG, IL1A
27captopril44 28 49 59 1112.9SLC15A1, TAC1, VIP, SST, CD79A
28n acetylcysteine448.8CD40LG, CCL11, CCL5, CAT, LTF, CD79A
29thyroxine44 249.8MBL2, SST, CD40LG, IL4, VIP, CD79A
30rantes448.8IL4, CD40LG, CD4, MBL2, CCL11, IL1A
31genistein44 28 59 2 11 2413.7CXCL10, CD4, CCL5, CCL11, IL1A, SST
32propranolol44 28 49 11 2412.7CCL5, SST, LTF, TAC1, VIP
33neopterin448.7CD40LG, IL1A, IL4, CXCL10, CD79A, CD4
34levodopa44 119.7CAT, SST, SLC15A1, TAC1, LTF
35prostaglandin448.6VIP, IL1A, TAC1, PTGES3
36h2o2448.5CAT, VIP, LTF, CD79A, DHFR, TAC1
37fmlp448.5SLC15A1, CCL11, CCL5, CSF3, LTF, IL1A
38methacholine44 119.4LTF, VIP, TAC1, IL4, CD79A, CCL5
39actinomycin d448.4CCL11, CAT, TAC1, LTF, CD40LG, IL4
40heparin44 28 11 2411.3CD40LG, TAC1, CCL11, CD4, CD79A, IL1A
41alanine448.2SLC15A1, LTF, CXCL10, DHFR, CD4, VIP
42lactate448.1DHFR, CD79A, CD40LG, SST, VIP, CAT
43adenylate448.0CXCL10, IL4, DHFR, VIP, SST, LTF
44retinoic acid44 248.9SST, CXCL10, DHFR, CD79A, CCL11, CCL5
45epinephrine44 11 249.8IL1A, TAC1, CD79A, CD40LG, SST, CSF3
46cyclosporin a44 28 599.7LTF, CCL11, CD40LG, CD79A, CCL5, IL4
47dexamethasone44 49 28 1110.7VIP, PTGES3, TAC1, CD79A, CD40LG, LTF
48histamine44 28 249.5CCL5, CXCL10, SST, LTF, CD40LG, CD79A
49vegf447.2CCL5, CSF3, SST, CCL11, CD40LG, VIP
50cysteine447.1SLC15A1, TAC1, IL4, DHFR, CD79A, CD40LG

GO Terms for genes affiliated with Cryptosporidiosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL4, CXCL10, CD79A, CD40LG, CD4
2extracellular regionGO:0055767.6IL1A, CXCL10, LTF, SST, MBL2, CCL5
3extracellular spaceGO:0056157.0CXCL10, SST, IL4, IL1A, TAC1, CSF3

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell activationGO:05086310.0CD4, CCL5
2eosinophil chemotaxisGO:0482459.9CCL5, CCL11
3positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, CD4
4B cell differentiationGO:0301839.7CD40LG, CD79A, IL4
5chemotaxisGO:0069359.6IL4, CXCL10, CCL5, CCL11
6B cell proliferationGO:0421009.6CD79A, CD40LG
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5CSF3, CAT, CCL5
8cell-cell signalingGO:0072679.0CCL5, SST, CXCL10, TAC1
9inflammatory responseGO:0069548.9TAC1, IL1A, CXCL10, CD40LG, CCL5, CCL11
10immune responseGO:0069558.8CCL11, CSF3, CD4, CXCL10, IL4, IL1A

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7IL1A, IL4, CD40LG, CSF3

Products for genes affiliated with Cryptosporidiosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet