MCID: CRY003
MIFTS: 62

Cryptosporidiosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Summaries for Cryptosporidiosis

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to microsporidiosis and diarrhea. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and IL4-mediated signaling events. The drug nitazoxanide and the compounds pneumococcal and pertussis have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and normal.

Disease Ontology:9 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:4 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:66 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 9 44 11 46 50 35 63
cryptosporidial gastroenteritis 9 63
infection by cryptosporidium 9
intestinal cryptosporidiosis 9


External Ids:

Disease Ontology9 DOID:1733
MeSH36 D003457
ICD9CM28 007.4
MESH via Orphanet37 D003457
ICD10 via Orphanet27 A07.2
SNOMED-CT via Orphanet60 240370009, 58777003
UMLS via Orphanet64 C0010418
ICD1026 A07.2

Related Diseases for Cryptosporidiosis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1microsporidiosis30.7CD4
2diarrhea30.6VIP, LTF, CD79A, CD4, TAC1, SST
3gastroenteritis30.3CD79A
4toxoplasmosis30.3CD4, DHFR, CD79A, CD40LG
5pancreatitis30.2LTF, TAC1, SST
6adenocarcinoma30.1TAC1, CXCL10, SST, VIP, CCL5
7acute graft versus host disease30.1CSF3, IL4
8graft versus host disease30.1CSF3, IL4, CCL5
9conjunctivitis30.1CD79A
10hepatitis30.0CCL11, CAT, CD4, CD40LG, CXCL10
11intestinal disease30.0SST
12pneumocystosis30.0DHFR, CD4
13shigellosis30.0CD79A, LTF
14chickenpox30.0CD4, CD79A
15sinusitis29.9CD79A, CCL11, CD4
16candidiasis29.9CD79A, LTF, CD4
17hepatitis c29.8CXCL10, CD40LG, LTF, IL4
18rhinitis29.8IL4, TAC1, CD79A, VIP, CCL5, CCL11
19gastritis29.7SST, CD4, CCL5, CD79A, LTF, CAT
20ulcerative colitis29.7IL1A, IL4, LTF, CD79A, TAC1, VIP
21leukemia29.5CAT, CD40LG, CD79A, CD4, IL4, DHFR
22giardiasis10.5
23acquired immunodeficiency syndrome10.3
24isosporiasis10.3
25hiv/aids10.3
26sclerosing cholangitis10.2
27cholangitis10.2
28cyclosporiasis10.2
29coccidiosis10.2
30folliculitis10.1CCL11
31rheumatic congestive heart failure10.1MBL2
32keratoconjunctivitis10.1CCL11
33keratopathy10.1TAC1
34keratoconjunctivitis sicca10.1LTF
35meningococcemia10.1CCL5
36q fever10.1CD79A
37lactose intolerance10.1LTF
38urethritis10.1CD79A
39cryptococcosis10.1CD4
40histoplasmosis10.1CD4
41poems syndrome10.1CD79A
42bronchiolitis10.1CCL11, CCL5
43listeriosis10.1CD4
44exanthem10.1CD79A
45macroglobulinemia10.1CD79A
46polyarteritis nodosa10.1LTF
47viral meningitis10.1CCL5, CXCL10
48eosinophilic pneumonia10.1CCL5, CCL11
49bronchitis10.1CD79A
50pancreatic cholera10.1SST, VIP

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Symptoms for Cryptosporidiosis

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Drugs & Therapeutics for Cryptosporidiosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Search CenterWatch for Cryptosporidiosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cryptosporidiosis

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Anatomical Context for Cryptosporidiosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Cryptosporidiosis:

34
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Cryptosporidiosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD40LG, CD79A, MBL2, TAC1, CSF3, IL4
2MP:00028737.3VIP, SST, CCL11, IL4, TAC1, CD4
3MP:00053976.7CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
4MP:00053766.7IL4, SST, CXCL10, VIP, IL1A, CAT
5MP:00053876.3LTF, VIP, CXCL10, SST, CCL5, CCL11

Publications for Cryptosporidiosis

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Sources:
53PubMed
See all sources

Articles related to Cryptosporidiosis:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. (22877562)
2013
2
Prevalence of cryptosporidiosis in dairy cattle, cattle-keeping families, their non-cattle-keeping neighbours and HIV-positive individuals in Dagoretti Division, Nairobi, Kenya. (22878888)
2012
3
Cryptosporidiosis-an overview. (22685452)
2012
4
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
5
Cryptosporidiosis surveillance--United States, 2009-2010. (22951493)
2012
6
Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. (22247151)
2012
7
Therapy and prevention of cryptosporidiosis in animals. (22521978)
2012
8
A trans-disciplinary study on the health risks of cryptosporidiosis from dairy systems in Dagoretti, Nairobi, Kenya: study background and farming system characteristics. (22886442)
2012
9
Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples. (21929875)
2011
10
Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. (21734132)
2011
11
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
12
Childhood cryptosporidiosis: a case report. (20936160)
2010
13
Cryptosporidiosis in the elderly population of the United States. (19199827)
2009
14
High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. (19954529)
2009
15
A hospital-based serological survey of cryptosporidiosis in the Republic of Korea. (19724694)
2009
16
A Bayesian evaluation of four immunological assays for the diagnosis of clinical cryptosporidiosis in calves. (17493849)
2008
17
Cryptosporidiosis in buffalo calves (Bubalus bubalis): prevalence and potential risk factors. (18575969)
2008
18
Development of fluorescent in situ hybridization for Cryptosporidium detection reveals zoonotic and anthroponotic transmission of sporadic cryptosporidiosis in Sydney. (18789979)
2008
19
Microscopy for cryptosporidiosis screening in remote areas. (18445972)
2008
20
An outbreak of cryptosporidiosis at a day-care centre in Sweden. (17868622)
2007
21
First reported waterborne outbreak of cryptosporidiosis with Cyclospora co-infection in Turkey. (17370959)
2007
22
High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. (17043107)
2007
23
Outbreak of cryptosporidiosis at a California waterpark: employee and patron roles and the long road towards prevention. (17291365)
2007
24
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
25
Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. (16886154)
2006
26
Effects of weather and river flow on cryptosporidiosis. (16459850)
2005
27
Cryptosporidium and cryptosporidiosis in Denmark--current status. (16252473)
2005
28
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
29
Cryptosporidiosis leading to an unsuspected diagnosis of AIDS. (15460500)
2004
30
Cryptosporidiosis in children in a north Jordanian paediatric hospital. (16335640)
2004
31
Disseminated cryptosporidiosis in Turkey: case report. (15250630)
2003
32
Foot and mouth disease in livestock and reduced cryptosporidiosis in humans, England and Wales. (12533277)
2003
33
Electrophoretic analysis of genetic variability within Cryptosporidium parvum from imported and autochthonous cases of human cryptosporidiosis in the United Kingdom. (12732542)
2003
34
Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosis. (13130414)
2003
35
An outbreak of cryptosporidiosis associated with an animal nursery at a regional fair. (12926737)
2003
36
Prevalence and control of bovine cryptosporidiosis in German dairy herds. (12623207)
2003
37
Cryptosporidiosis. (12686887)
2002
38
Novel cryptosporidium genotypes in sporadic cryptosporidiosis cases: first report of human infections with a cervine genotype. (11927023)
2002
39
PCR-ELISA: a new simplified tool for tracing the source of cryptosporidiosis in HIV-positive patients. (11763435)
2001
40
From the Centers for Disease Control and Prevention. Protracted outbreaks of cryptosporidiosis associated with swimming pool use--Ohio and Nebraska, 2000. (11439938)
2001
41
Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in suckling calves. (11232925)
2001
42
Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis. (11518676)
2001
43
Cryptosporidiosis in Kuwaiti children: seasonality and endemicity. (11422253)
2001
44
Compliance with advice to boil drinking water during an outbreak of cryptosporidiosis. Outbreak Investigation Team. (10902259)
2000
45
Emerging public health concerns regarding cryptosporidiosis. (10976295)
2000
46
Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. (10669358)
2000
47
Role of the enteric nervous system in piglet cryptosporidiosis. (8968331)
1996
48
Coccidiosis and cryptosporidiosis in sheep and goats. (2245367)
1990
49
Mycobacterium marinum infection in a patient with cryptosporidiosis and the acquired immunodeficiency syndrome. (3203532)
1988
50
Cryptosporidiosis and isosporiasis in patients with AIDS. (3060532)
1988

Variations for Cryptosporidiosis

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Expression for genes affiliated with Cryptosporidiosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 5Cell Signaling Technology, 54QIAGEN
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Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CCL11, CCL5, CXCL10
29.4CCL11, IL4, CD40LG
39.4IL1A, IL4, CXCL10
49.4CD4, CD79A, CD40LG
5
Show member pathways
9.3CD40LG, IL1A, IL4
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.2CXCL10, CCL11, IL4, IL1A
7
Show member pathways
9.1CXCL10, CCL5, IL4, IL1A
89.0SST, IL1A, TAC1
98.9CD79A, CD4, IL4, CCL5
10
Show member pathways
8.7CCL5, CCL11, IL4, IL1A, CD4
118.7IL4, IL1A, CSF3, CD4
128.7CD4, CSF3, IL1A, IL4
13
Show member pathways
8.7CCL11, IL4, IL1A, CD4, CD40LG
14
Show member pathways
8.6CXCL10, SST, CCL5, CCL11, TAC1
15
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5IL4, IL1A, CD4, CD79A, CD40LG
16
Show member pathways
8.4CXCL10, SST, CCL5, CCL11, TAC1, VIP
17
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
18
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
19
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
20
Show member pathways
7.7CD40LG, CXCL10, CCL5, CCL11, IL4, IL1A

Compounds for genes affiliated with Cryptosporidiosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB, 52PharmGKB
See all sources

Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 232)
idCompoundScoreTop Affiliating Genes
1pneumococcal469.6CD79A, LTF, DHFR, CD40LG
2pertussis469.5CCL11, VIP, CCL5, LTF, SST
3lactose46 1210.4LTF, CD40LG, DHFR, MBL2, SST
4pmma469.3CD40LG, LTF, CCL5, CD79A
5ccl346 3010.2CXCL10, CCL5, CCL11, CSF3, IL1A
6hemocyanin469.1CD4, CD40LG, CD79A, IL4
7allergens469.1CXCL10, CD40LG, CD79A, IL4, CCL11
8leukotriene b446 62 2511.1LTF, IL1A, CCL11, CCL5, CXCL10
9anti-fungal468.9DHFR, CSF3, MBL2, CD79A, CD40LG, LTF
10tarc468.9CXCL10, CD4, IL1A, IL4, CCL11, CCL5
11chloroquine46 3 52 30 1212.9CD79A, IL4, CXCL10, DHFR, CD4
12hydrocortisone46 3 62 1211.9LTF, SST, CCL5, IL1A, IL4, CXCL10
13thyroxine46 259.9CD79A, VIP, MBL2, SST, CD40LG, IL4
14mannan468.9MBL2, CD79A, CD40LG, CD4
15captopril46 62 52 30 1212.8VIP, SST, TAC1, IL1A, CD79A
16polyethylene glycol468.8VIP, CD79A, IL4, CD40LG, IL1A
17ribavirin46 52 1210.7IL4, CXCL10, LTF, MBL2, CSF3, CD40LG
18propranolol46 30 52 25 1212.7CCL5, VIP, TAC1, LTF, SST
19genistein46 30 62 3 25 1213.7CXCL10, SST, IL1A, CD40LG, CCL5, CD4
20endotoxin468.7LTF, CSF3, IL1A, CD40LG, CXCL10, CCL5
21lactate468.5CD40LG, CCL5, CAT, SST, DHFR, VIP
22creatinine468.4LTF, CD79A, MBL2, IL1A, CCL5, CXCL10
23n acetylcysteine468.4CCL11, CCL5, CAT, CD79A, CD40LG, LTF
24fmlp468.3IL1A, CCL11, LTF, CSF3, CCL5, TAC1
25isoproterenol46 129.2VIP, LTF, TAC1, IL1A, IL4, SST
26alanine468.2VIP, LTF, CD40LG, CD79A, CD4, CCL11
27neopterin468.2CD79A, CD40LG, LTF, MBL2, IL4, IL1A
28norepinephrine46 25 1210.1IL1A, LTF, CD40LG, CD79A, TAC1, VIP
29methacholine46 52 1210.1VIP, CCL5, CCL11, IL4, LTF, CD79A
30cyclophosphamide46 52 1210.0MBL2, TAC1, CSF3, IL4, SST, DHFR
31aspartate467.9TAC1, LTF, CD40LG, MBL2, IL1A, VIP
32adenylate467.9CXCL10, DHFR, SST, IL4, TAC1, CD40LG
33cycloheximide467.8CXCL10, CCL5, SST, IL4, IL1A, CSF3
34nitric oxide46 25 129.8VIP, CXCL10, CCL5, CCL11, IL1A, CAT
35heparin46 30 25 1210.8TAC1, CCL5, CCL11, IL1A, CD4, LTF
36actinomycin d467.8LTF, CD40LG, IL4, CCL11, IL1A, CAT
37estrogen467.8LTF, CD79A, CD40LG, CXCL10, DHFR, CCL5
38retinoic acid46 258.8CCL5, CXCL10, DHFR, LTF, SST, CD79A
39cyclosporin a46 30 629.8CD40LG, CD79A, VIP, CCL11, IL1A, CSF3
40epinephrine46 25 129.8IL1A, SST, VIP, TAC1, CD40LG, CD79A
41h2o2467.8DHFR, VIP, CCL5, IL1A, TAC1, CAT
42rantes467.6CD4, MBL2, CSF3, IL1A, IL4, CCL11
43arginine467.6CD79A, TAC1, IL1A, IL4, SST, CD40LG
44glutamate467.3VIP, DHFR, SST, LTF, CD40LG, CD79A
45histamine46 30 259.3TAC1, IL4, CCL11, CCL5, SST, CXCL10
46vegf467.0MBL2, VIP, CD79A, CD40LG, LTF, IL1A
47indomethacin46 30 62 1210.0CCL5, VIP, CCL11, IL4, IL1A, CAT
48cysteine466.7CD40LG, MBL2, CD79A, CD4, LTF, TAC1
49pge2466.5CXCL10, SST, CCL5, CCL11, IL4, IL1A
50dexamethasone46 52 30 129.2MBL2, TAC1, CSF3, IL1A, IL4, CCL11

GO Terms for genes affiliated with Cryptosporidiosis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CD40LG, CD79A, CD4, IL4, CXCL10
2extracellular regionGO:0055767.2VIP, CXCL10, SST, CCL5, CCL11, IL1A
3extracellular spaceGO:0056156.3LTF, CXCL10, SST, CCL5, CCL11, IL4

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0CCL11, CCL5
2regulation of T cell activationGO:05086310.0CD4, CCL5
3leukocyte cell-cell adhesionGO:0071599.9CD40LG, CCL5
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, IL1A
5innate immune response in mucosaGO:0022279.7IL4, LTF
6cellular response to heatGO:0346059.6IL1A, CXCL10
7chemotaxisGO:0069359.5CXCL10, CCL5, CCL11, IL4
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5CCL5, CSF3, CAT
9cell surface receptor signaling pathwayGO:0071669.4CXCL10, SST, CD4
10B cell differentiationGO:0301839.4CD40LG, CD79A, IL4
11cell-cell signalingGO:0072679.0CXCL10, SST, CCL5, TAC1
12negative regulation of apoptotic processGO:0430668.8LTF, CD40LG, CAT, IL4, VIP
13inflammatory responseGO:0069548.6CD40LG, TAC1, IL1A, CCL11, CCL5, CXCL10
14immune responseGO:0069558.5CXCL10, CCL11, IL4, IL1A, CSF3, CD4

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.4CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7CD40LG, CSF3, IL1A, IL4
3protein bindingGO:0055156.9CXCL10, CCL5, CCL11, IL4, IL1A, TAC1

Products for genes affiliated with Cryptosporidiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet