MCID: CRY003
MIFTS: 60

Cryptosporidiosis malady

Infectious diseases, Gastrointestinal diseases categories

Summaries for Cryptosporidiosis

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to diarrhea and microsporidiosis. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Cytokines and Inflammatory Response and Rho Family GTPases. The drug nitazoxanide and the compounds hydrocortisone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:63 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 8 42 10 44 48 33 60
cryptosporidial gastroenteritis 8 60
infection by cryptosporidium 8
intestinal cryptosporidiosis 8


External Ids:

Disease Ontology8 DOID:1733
ICD9CM27 007.4
MeSH34 D003457
MESH via Orphanet35 D003457
ICD10 via Orphanet26 A07.2
SNOMED-CT via Orphanet57 240370009, 58777003
UMLS via Orphanet61 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.6TAC1, CD79A, CD4, LTF, SST, VIP
2microsporidiosis30.5CD4
3acquired immunodeficiency syndrome30.3DHFR, CD4
4toxoplasmosis30.1DHFR, CD79A, CD40LG, CD4
5pancreatitis30.0TAC1, LTF, SST
6graft versus host disease30.0IL4, CSF3, CCL5
7hepatitis30.0CXCL10, CD40LG, CD4, CAT, CCL11
8adenocarcinoma30.0TAC1, CXCL10, SST, CCL5, VIP
9crohn's disease29.8LTF
10ankylosing spondylitis29.8CD79A
11conjunctivitis29.8CD79A
12cd40 ligand deficiency29.8CD40LG
13acute leukemia29.8DHFR, CSF3
14colorectal cancer29.8DHFR, CD4, LTF
15pneumocystosis29.8DHFR, CD4
16candidiasis29.8CD79A, CD4, LTF
17pancreatic cancer29.8SST, VIP
18hepatitis c29.8IL4, CXCL10, CD40LG, LTF
19rhinitis29.8TAC1, IL4, CD79A, CCL5, CCL11, VIP
20gastritis29.8CD79A, CD4, LTF, SST, CAT, CCL5
21ulcerative colitis29.8SLC15A1, TAC1, IL1A, IL4, CXCL10, CD79A
22leukemia29.7IL1A, IL4, DHFR, CD79A, CD40LG, CD4
23giardiasis10.5
24sclerosing cholangitis10.2
25cholangitis10.2
26acute diarrhea10.1
27cyclosporiasis10.1
28coccidiosis10.1
29gastroenteritis10.1
30hepatitis a10.0
31cholangiocarcinoma10.0
32intestinal disease10.0
33mouth disease10.0
34kawasaki disease10.0MBL2
35rheumatic fever10.0MBL2
36keratoconjunctivitis10.0CCL11
37stomach cancer10.0MBL2
38dementia10.0CXCL10
39paracoccidioidomycosis10.0CXCL10
40neuritis10.0CCL5
41complex regional pain syndrome10.0TAC1
42schizophrenia10.0TAC1
43parkinson's disease10.0TAC1
44biliary atresia10.0CXCL10
45glioblastoma multiforme10.0TAC1
46severe acute respiratory syndrome10.0CXCL10
47sudden infant death syndrome10.0TAC1
48periodontitis10.0IL1A
49fanconi's anemia10.0DHFR
50keratoconjunctivitis sicca10.0LTF

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Clinical Features for Cryptosporidiosis

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Drugs & Therapeutics for Cryptosporidiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Search CenterWatch for Cryptosporidiosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cryptosporidiosis

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Anatomical Context for Cryptosporidiosis

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32MalaCards
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MalaCards organs/tissues related to Cryptosporidiosis:

32
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cryptosporidiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9TAC1
2MP:00053977.2CCL11, CCL5, MBL2, CSF3, LTF, CD4
3MP:00053876.4IL1A, VIP, CCL11, CCL5, MBL2, CSF3
4MP:00053765.9LTF, SST, MBL2, CAT, VIP, CD4

Publications for Cryptosporidiosis

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Sources:
50PubMed
See all sources

Articles related to Cryptosporidiosis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Integration of halofuginone lactate treatment and disinfection with p-chloro-m-cresol to control natural cryptosporidiosis in calves. (23561324)
2013
2
Human cryptosporidiosis diagnosed in Western Australia: a mixed infection with Cryptosporidium meleagridis, the Cryptosporidium mink genotype, and an unknown Cryptosporidium species. (23637295)
2013
3
Cryptosporidiosis: comparison of three diagnostic methods and effects of storage temperature on detectability of cryptosporidia in cattle faeces. (22246371)
2012
4
Outbreak of cryptosporidiosis associated with a firefighting response - Indiana and Michigan, June 2011. (22398843)
2012
5
Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples. (21929875)
2011
6
Cryptosporidiosis in children with acute lymphoblastic leukemia on maintenance chemotherapy. (21941152)
2011
7
Cryptosporidiosis among HIV-infected persons in the Niger Delta of Nigeria. (21970221)
2011
8
Serum IgG response to Cryptosporidium immunodominant antigen gp15 and polymorphic antigen gp40 in children with cryptosporidiosis in South India. (21288997)
2011
9
Zoonotic cryptosporidiosis in the UK - challenges for control. (20497274)
2010
10
Colonic cryptosporidiosis in allograft patients: a rare differential diagnosis of acute graft-versus-host disease. (20466123)
2010
11
A modified case-control study of cryptosporidiosis (using non-Cryptosporidium-infected enteric cases as controls) in a community setting. (19527550)
2009
12
Glycoprotein 60 diversity in C. hominis and C. parvum causing human cryptosporidiosis in NSW, Australia. (19233175)
2009
13
Microscopy for cryptosporidiosis screening in remote areas. (18445972)
2008
14
A longitudinal study of cryptosporidiosis in dairy cattle from birth to 2 years of age. (18565677)
2008
15
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. (18215774)
2008
16
Cryptosporidiosis in 20 alpaca crias. (18627238)
2008
17
High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. (17043107)
2007
18
Cryptosporidiosis in a relapsed case of Hodgkin's disease. (17611349)
2007
19
Cryptosporidiosis in developing countries. (19734601)
2007
20
Incidence of cryptosporidiosis species in paediatric patients in Malawi. (17224087)
2007
21
Asymptomatic cryptosporidiosis in Zambian dairy farm workers and their household members. (17368697)
2007
22
Intestinal cryptosporidiosis in turkeys in Iran. (16901269)
2006
23
A family outbreak of cryptosporidiosis: Probable nosocomial infection and person-to-person transmission. (16957980)
2006
24
A small outbreak of human cryptosporidiosis associated with calves at a dairy farm in Norway. (16938738)
2006
25
Managing a cluster of cryptosporidiosis associated with a public swimming pool. (17036085)
2006
26
Epidemiological and clinical features of travel-associated cryptosporidiosis. (16882300)
2006
27
Treatment of chronic cryptosporidiosis in AIDS with rIL-12 induces an immune response associated with improvement but severe side-effects. (16052094)
2005
28
Cryptosporidiosis in children in a north Jordanian paediatric hospital. (16335640)
2004
29
Nitazoxanide treatment for giardiasis and cryptosporidiosis in children. (14990779)
2004
30
A review of the biology and epidemiology of cryptosporidiosis in humans and animals. (15207825)
2004
31
Cryptosporidiosis susceptibility and risk: a case study. (15028013)
2004
32
Disseminated cryptosporidiosis in Turkey: case report. (15250630)
2003
33
Cryptosporidiosis associated with animal contacts. (12674690)
2003
34
Laboratory diagnosis of cryptosporidiosis. (12432203)
2002
35
Cryptosporidiosis among animal handlers and their livestock in Basrah, Iraq. (12635763)
2002
36
Incidence of cryptosporidiosis in immunodeficient cancer patients in Egypt. (12049267)
2002
37
Genomics and genetics of Cryptosporidium parvum: the key to understanding cryptosporidiosis. (12191658)
2002
38
Introduction. Cryptosporidiosis: current trends and challenges. (12191654)
2002
39
Cryptosporidiosis in Kuwaiti children: seasonality and endemicity. (11422253)
2001
40
Race/ethnicity and other risk of factors associated with cryptosporidiosis as an initial AIDS-defining condition in California, 1980-99. (11811888)
2001
41
Community surveys of self-reported diarrhoea can dramatically overestimate the size of outbreaks of waterborne cryptosporidiosis. (11464765)
2001
42
Evidence for the emergence of a type-1-like immune response in intestinal mucosa of calves recovering from cryptosporidiosis. (11227908)
2001
43
Enzyme immunoassay detection of antigen-specific immunoglobulin g antibodies in longitudinal serum samples from patients with cryptosporidiosis. (11238231)
2001
44
Outbreak of cryptosporidiosis after contamination of the public water supply in Saitama Prefecture, Japan, in 1996. (10916342)
2000
45
Outbreak of cryptosporidiosis in Lancashire. (10777994)
2000
46
Efficacy of treatment with paromomycin, azithromycin, and nitazoxanide in a patient with disseminated cryptosporidiosis. (10691200)
1999
47
Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy. (9457096)
1998
48
Zoonotic transmission of Cryptosporidium parvum: Implications for water-borne cryptosporidiosis. (15275048)
1997
49
Parasitic infections in AIDS patients. Cryptosporidiosis, isosporiasis, microsporidiosis, cyclosporiasis. (8254160)
1993
50
Mycobacterium marinum infection in a patient with cryptosporidiosis and the acquired immunodeficiency syndrome. (3203532)
1988

Genetic Variations for Cryptosporidiosis

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Expression for genes affiliated with Cryptosporidiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
10.0CXCL10, CD4
39.9CD79A, CD4
49.8CCL11, CCL5, CXCL10
59.7IL4, CXCL10, CCL11
69.6IL4, CD40LG, CCL11
79.2CCL5, CD4, CD79A, IL4
8
Hide members
9.1CCL11, CCL5, CD4, IL4, IL1A
9
Hide members
9.0CCL11, CD4, CD40LG, IL4, IL1A
109.0CSF3, CD4, IL4, IL1A
11
Hide members
9.0CCL11, CCL5, CSF3, CD4, CXCL10
12
Hide members
8.9IL1A, CXCL10, CD4, CSF3, CCL11
13
Hide members
8.9IL1A, IL4, CD79A, CD40LG, CD4
14
Hide members
8.8TAC1, CXCL10, SST, CCL5, CCL11
15
Hide members
8.3CXCL10, CD4, CSF3, CCL5, CCL11, IL4

Compounds for genes affiliated with Cryptosporidiosis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6LTF
2endotoxin4410.1CSF3, LTF
3cycloheximide449.9CXCL10, CAT, CD4
4pneumococcal449.8LTF, CD79A, CD40LG, DHFR
5glutamate449.8TAC1, CD40LG, SLC15A1
6mannan449.7CD4, MBL2, CD79A
7pmma449.6CD40LG, CD79A, CCL5, LTF
8indomethacin44 59 28 1112.6VIP, LTF, TAC1
9hemocyanin449.5CD40LG, CD79A, IL4, CD4
10lactose44 1110.5MBL2, SST, LTF, DHFR, CD40LG
11estrogen449.5CD79A, TAC1, MBL2, LTF
12norepinephrine44 11 2411.5VIP, TAC1, LTF
13polymyxin b449.4MBL2, IL4, IL1A, LTF
14allergens449.4IL4, CXCL10, CD79A, CD40LG, CCL11
15ccl344 2810.3IL1A, CCL5, CSF3, CCL11, CXCL10
16n-formylmethionyl-leucylphenylalanine449.3CCL11, CSF3, IL1A, LTF, SLC15A1
17pertussis449.3SST, CCL5, LTF, CCL11, VIP
18tarc449.3IL1A, IL4, CXCL10, CD4, CCL5, CCL11
19chloroquine44 2 49 28 1113.2CD4, IL4, CXCL10, DHFR, CD79A
20isoproterenol44 1110.2IL1A, TAC1, LTF, SST
21pge2449.2PTGES3, CD4, CCL11, SST
22anti-fungal449.1MBL2, CSF3, LTF, CD40LG, CD79A, DHFR
23ribavirin44 49 1111.1CSF3, MBL2, LTF, CXCL10, IL4, CD40LG
24leukotriene b444 59 2411.0CCL11, CCL5, LTF, IL1A, CXCL10
25cyclophosphamide44 49 1110.9TAC1, DHFR, SST, CSF3, MBL2
26polyethylene glycol448.9IL4, CD79A, VIP, CD40LG, IL1A
27captopril44 28 49 59 1112.9SLC15A1, TAC1, VIP, SST, CD79A
28n acetylcysteine448.8CD40LG, CCL11, CCL5, CAT, LTF, CD79A
29thyroxine44 249.8MBL2, SST, CD40LG, IL4, VIP, CD79A
30rantes448.8IL4, CD40LG, CD4, MBL2, CCL11, IL1A
31genistein44 28 59 2 11 2413.7CXCL10, CD4, CCL5, CCL11, IL1A, SST
32propranolol44 28 49 11 2412.7CCL5, SST, LTF, TAC1, VIP
33neopterin448.7CD40LG, IL1A, IL4, CXCL10, CD79A, CD4
34levodopa44 119.7CAT, SST, SLC15A1, TAC1, LTF
35prostaglandin448.6VIP, IL1A, TAC1, PTGES3
36h2o2448.5CAT, VIP, LTF, CD79A, DHFR, TAC1
37fmlp448.5SLC15A1, CCL11, CCL5, CSF3, LTF, IL1A
38methacholine44 119.4LTF, VIP, TAC1, IL4, CD79A, CCL5
39actinomycin d448.4CCL11, CAT, TAC1, LTF, CD40LG, IL4
40heparin44 28 11 2411.3CD40LG, TAC1, CCL11, CD4, CD79A, IL1A
41alanine448.2SLC15A1, LTF, CXCL10, DHFR, CD4, VIP
42lactate448.1DHFR, CD79A, CD40LG, SST, VIP, CAT
43adenylate448.0CXCL10, IL4, DHFR, VIP, SST, LTF
44retinoic acid44 248.9SST, CXCL10, DHFR, CD79A, CCL11, CCL5
45epinephrine44 11 249.8IL1A, TAC1, CD79A, CD40LG, SST, CSF3
46cyclosporin a44 28 599.7LTF, CCL11, CD40LG, CD79A, CCL5, IL4
47dexamethasone44 49 28 1110.7VIP, PTGES3, TAC1, CD79A, CD40LG, LTF
48histamine44 28 249.5CCL5, CXCL10, SST, LTF, CD40LG, CD79A
49vegf447.2CCL5, CSF3, SST, CCL11, CD40LG, VIP
50cysteine447.1SLC15A1, TAC1, IL4, DHFR, CD79A, CD40LG

GO Terms for genes affiliated with Cryptosporidiosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7CD4, CD40LG, CD79A, CXCL10, IL4
2extracellular regionGO:0055767.6CCL11, CCL5, MBL2, SST, LTF, CXCL10
3extracellular spaceGO:0056157.0TAC1, CCL11, CCL5, MBL2, CSF3, SST

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell activationGO:05086310.0CD4, CCL5
2eosinophil chemotaxisGO:0482459.9CCL5, CCL11
3positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, CD4
4B cell differentiationGO:0301839.7CD40LG, CD79A, IL4
5chemotaxisGO:0069359.6IL4, CXCL10, CCL5, CCL11
6B cell proliferationGO:0421009.6CD79A, CD40LG
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5CSF3, CAT, CCL5
8cell-cell signalingGO:0072679.0CCL5, SST, CXCL10, TAC1
9inflammatory responseGO:0069548.9TAC1, IL1A, CXCL10, CD40LG, CCL5, CCL11
10immune responseGO:0069558.8CCL11, CSF3, CD4, CXCL10, IL4, IL1A

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7IL1A, IL4, CD40LG, CSF3

Products for genes affiliated with Cryptosporidiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet