MCID: CRY003
MIFTS: 60

Cryptosporidiosis malady

Infectious diseases, Gastrointestinal diseases categories

Summaries for Cryptosporidiosis

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to diarrhea and microsporidiosis. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Cytokines and Inflammatory Response and Rho Family GTPases. The drug nitazoxanide and the compounds hydrocortisone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:63 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 8 42 10 44 48 33 60
cryptosporidial gastroenteritis 8 60
infection by cryptosporidium 8
intestinal cryptosporidiosis 8


External Ids:

Disease Ontology8 DOID:1733
ICD9CM27 007.4
MeSH34 D003457
MESH via Orphanet35 D003457
ICD10 via Orphanet26 A07.2
SNOMED-CT via Orphanet57 240370009, 58777003
UMLS via Orphanet61 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.6TAC1, CD79A, CD4, LTF, SST, VIP
2microsporidiosis30.5CD4
3acquired immunodeficiency syndrome30.3DHFR, CD4
4toxoplasmosis30.1DHFR, CD79A, CD40LG, CD4
5pancreatitis30.0TAC1, LTF, SST
6graft versus host disease30.0IL4, CSF3, CCL5
7hepatitis30.0CXCL10, CD40LG, CD4, CAT, CCL11
8adenocarcinoma30.0TAC1, CXCL10, SST, CCL5, VIP
9crohn's disease29.8LTF
10ankylosing spondylitis29.8CD79A
11conjunctivitis29.8CD79A
12cd40 ligand deficiency29.8CD40LG
13acute leukemia29.8DHFR, CSF3
14colorectal cancer29.8DHFR, CD4, LTF
15pneumocystosis29.8DHFR, CD4
16candidiasis29.8CD79A, CD4, LTF
17pancreatic cancer29.8SST, VIP
18hepatitis c29.8IL4, CXCL10, CD40LG, LTF
19rhinitis29.8TAC1, IL4, CD79A, CCL5, CCL11, VIP
20gastritis29.8CD79A, CD4, LTF, SST, CAT, CCL5
21ulcerative colitis29.8SLC15A1, TAC1, IL1A, IL4, CXCL10, CD79A
22leukemia29.7IL1A, IL4, DHFR, CD79A, CD40LG, CD4
23giardiasis10.5
24sclerosing cholangitis10.2
25cholangitis10.2
26acute diarrhea10.1
27cyclosporiasis10.1
28coccidiosis10.1
29gastroenteritis10.1
30hepatitis a10.0
31cholangiocarcinoma10.0
32intestinal disease10.0
33mouth disease10.0
34kawasaki disease10.0MBL2
35rheumatic fever10.0MBL2
36keratoconjunctivitis10.0CCL11
37stomach cancer10.0MBL2
38dementia10.0CXCL10
39paracoccidioidomycosis10.0CXCL10
40neuritis10.0CCL5
41complex regional pain syndrome10.0TAC1
42schizophrenia10.0TAC1
43parkinson's disease10.0TAC1
44biliary atresia10.0CXCL10
45glioblastoma multiforme10.0TAC1
46severe acute respiratory syndrome10.0CXCL10
47sudden infant death syndrome10.0TAC1
48periodontitis10.0IL1A
49fanconi's anemia10.0DHFR
50keratoconjunctivitis sicca10.0LTF

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Clinical Features for Cryptosporidiosis

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Drugs & Therapeutics for Cryptosporidiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Search CenterWatch for Cryptosporidiosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cryptosporidiosis

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Anatomical Context for Cryptosporidiosis

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32MalaCards
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MalaCards organs/tissues related to Cryptosporidiosis:

32
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Cryptosporidiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9TAC1
2MP:00053977.2CCL11, CCL5, MBL2, CSF3, LTF, CD4
3MP:00053876.4IL1A, VIP, CCL11, CCL5, MBL2, CSF3
4MP:00053765.9LTF, SST, MBL2, CAT, VIP, CD4

Publications for Cryptosporidiosis

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Sources:
50PubMed
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Articles related to Cryptosporidiosis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Preventing cryptosporidiosis: the need for safe drinking water. (23599543)
2013
2
Crypto-Giardia antigen rapid test versus conventional modified Ziehl-Neelsen acid fast staining method for diagnosis of cryptosporidiosis. (23375035)
2013
3
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
4
Effect of immunosuppression on the course of cryptosporidiosis experimentally. (23469638)
2012
5
Molecular epidemiology, spatiotemporal analysis, and ecology of sporadic human cryptosporidiosis in Australia. (21908628)
2011
6
In a trial of the use of miltefosine to treat HIV-related cryptosporidiosis in Zambian adults, extreme metabolic disturbances contribute to high mortality. (21396249)
2011
7
Cryptosporidiosis: host immune responses and the prospects for effective immunotherapies. (22029525)
2011
8
Diagnosis and treatment of digestive cryptosporidiosis in allogeneic haematopoietic stem cell transplant recipients: a prospective single centre study. (20729925)
2011
9
Zoonotic cryptosporidiosis from petting farms, England and Wales, 1992-2009. (21192888)
2011
10
Evaluation of DNA encoding acidic ribosomal protein P2 of Cryptosporidium parvum as a potential vaccine candidate for cryptosporidiosis. (21968447)
2011
11
Bayesian classification and regression trees for predicting incidence of cryptosporidiosis. (21909377)
2011
12
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
13
Spatial and temporal epidemiology of sporadic human cryptosporidiosis in Scotland. (19638164)
2010
14
Cryptosporidiosis in paediatric renal transplantation. (19714369)
2009
15
Cryptosporidiosis from a community swimming pool: outbreak investigation and follow-up study. (19426570)
2009
16
Catching up with cryptosporidiosis. (18813011)
2008
17
Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis. (18498239)
2008
18
Seasonal profile and level of CD4+ lymphocytes in the occurrence of cryptosporidiosis and cystoisosporidiosis in HIV/AIDS patients in the TriAcngulo Mineiro region, Brazil. (17992404)
2007
19
Is nitazoxanide an effective treatment for patients with acquired immune deficiency syndrome-related cryptosporidiosis? (17245327)
2007
20
Case-control study of environmental and social factors influencing cryptosporidiosis. (17891460)
2007
21
Efficacy of nitazoxanide against experimental cryptosporidiosis in goat neonates. (17874133)
2007
22
Cryptosporidiosis induces a transient upregulation of the oligopeptides transporter (PepT1) activity in neonatal rats. (17327480)
2007
23
Pulmonary cryptosporidiosis: role of COX2 and NF-kB. (17004971)
2006
24
Zoonotic cryptosporidiosis in man and animal in farms, Giza Governorate, Egypt. (17366871)
2006
25
The investigation of an outbreak of cryptosporidiosis in New South Wales in 2005. (17036084)
2006
26
Cryptosporidium and cryptosporidiosis in Denmark--current status. (16252473)
2005
27
An outbreak of cryptosporidiosis in Wales, November 2005. (16794291)
2005
28
Oral administration of hyperimmune anti-Cryptosporidium parvum ovine colostral whey confers a high level of protection against cryptosporidiosis in newborn NMRI mice. (16108564)
2005
29
Effect of different decoquinate treatments on cryptosporidiosis in naturally infected cashmere goat kids. (16127138)
2005
30
Risk factors for sporadic cryptosporidiosis among immunocompetent persons in the United States from 1999 to 2001. (15243043)
2004
31
Cryptosporidiosis among Bangladeshi children with diarrhea: a prospective, matched, case-control study of clinical features, epidemiology and systemic antibody responses. (15516636)
2004
32
Gallbladder cryptosporidiosis in a patient with acquired immunodeficiency syndrome: sonographic evaluation of the disease's course. (14756363)
2004
33
Prevalence of cryptosporidiosis among the villagers and domestic animals in several rural areas of Korea. (15060334)
2004
34
A quantitative risk assessment of waterborne cryptosporidiosis in France using second-order Monte Carlo simulation. (15027996)
2004
35
Enhancing surveillance of cryptosporidiosis: test all faecal specimens from children. (12166295)
2002
36
Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis. (11796330)
2002
37
Cryptosporidiosis. (12037153)
2002
38
Risk and control of waterborne cryptosporidiosis. (12069877)
2002
39
Cryptosporidiosis and travelers. (11486569)
2001
40
Rapid increase of mucosal CD4 T cells followed by clearance of intestinal cryptosporidiosis in an AIDS patient receiving highly active antiretroviral therapy. (11231952)
2001
41
High prevalence and seasonality of cryptosporidiosis in a small rural village occupied predominantly by aged people in the Republic of Korea. (11716107)
2001
42
An outbreak of cryptosporidiosis in an urban swimming pool: why are such outbreaks difficult to detect? (10937403)
2000
43
Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children. (10653343)
2000
44
Risk factors, seasonality, and trends of cryptosporidiosis among patients infected with human immunodeficiency virus. (11037782)
2000
45
Clinical aspects of human cryptosporidiosis. (10943507)
2000
46
Gastric cryptosporidiosis as a clue for the diagnosis of the acquired immunodeficiency syndrome. (11236271)
2000
47
Outbreak of cryptosporidiosis in Northern Ireland. (11014048)
2000
48
Case of cryptosporidiosis in an Iraqi woman with ulcerative colitis. (10793796)
1999
49
Serum cytokines as predictors of clinical outcome in AIDS-related intestinal cryptosporidiosis. (9675651)
1998
50
Some Opportunistic Parasitic Infections in AIDS: Candidiasis, Pneumocystosis, Cryptosporidiosis, Toxoplasmosis. (17040733)
1998

Genetic Variations for Cryptosporidiosis

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Expression for genes affiliated with Cryptosporidiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
10.0CXCL10, CD4
39.9CD79A, CD4
49.8CCL11, CCL5, CXCL10
59.7IL4, CXCL10, CCL11
69.6IL4, CD40LG, CCL11
79.2CCL5, CD4, CD79A, IL4
8
Hide members
9.1CCL11, CCL5, CD4, IL4, IL1A
9
Hide members
9.0CCL11, CD4, CD40LG, IL4, IL1A
109.0CSF3, CD4, IL4, IL1A
11
Hide members
9.0CCL11, CCL5, CSF3, CD4, CXCL10
12
Hide members
8.9IL1A, CXCL10, CD4, CSF3, CCL11
13
Hide members
8.9IL1A, IL4, CD79A, CD40LG, CD4
14
Hide members
8.8TAC1, CXCL10, SST, CCL5, CCL11
15
Hide members
8.3CXCL10, CD4, CSF3, CCL5, CCL11, IL4

Compounds for genes affiliated with Cryptosporidiosis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6LTF
2endotoxin4410.1CSF3, LTF
3cycloheximide449.9CXCL10, CAT, CD4
4pneumococcal449.8LTF, CD79A, CD40LG, DHFR
5glutamate449.8TAC1, CD40LG, SLC15A1
6mannan449.7CD4, MBL2, CD79A
7pmma449.6CD40LG, CD79A, CCL5, LTF
8indomethacin44 59 28 1112.6VIP, LTF, TAC1
9hemocyanin449.5CD40LG, CD79A, IL4, CD4
10lactose44 1110.5MBL2, SST, LTF, DHFR, CD40LG
11estrogen449.5CD79A, TAC1, MBL2, LTF
12norepinephrine44 11 2411.5VIP, TAC1, LTF
13polymyxin b449.4MBL2, IL4, IL1A, LTF
14allergens449.4IL4, CXCL10, CD79A, CD40LG, CCL11
15ccl344 2810.3IL1A, CCL5, CSF3, CCL11, CXCL10
16n-formylmethionyl-leucylphenylalanine449.3CCL11, CSF3, IL1A, LTF, SLC15A1
17pertussis449.3SST, CCL5, LTF, CCL11, VIP
18tarc449.3IL1A, IL4, CXCL10, CD4, CCL5, CCL11
19chloroquine44 2 49 28 1113.2CD4, IL4, CXCL10, DHFR, CD79A
20isoproterenol44 1110.2IL1A, TAC1, LTF, SST
21pge2449.2PTGES3, CD4, CCL11, SST
22anti-fungal449.1MBL2, CSF3, LTF, CD40LG, CD79A, DHFR
23ribavirin44 49 1111.1CSF3, MBL2, LTF, CXCL10, IL4, CD40LG
24leukotriene b444 59 2411.0CCL11, CCL5, LTF, IL1A, CXCL10
25cyclophosphamide44 49 1110.9TAC1, DHFR, SST, CSF3, MBL2
26polyethylene glycol448.9IL4, CD79A, VIP, CD40LG, IL1A
27captopril44 28 49 59 1112.9SLC15A1, TAC1, VIP, SST, CD79A
28n acetylcysteine448.8CD40LG, CCL11, CCL5, CAT, LTF, CD79A
29thyroxine44 249.8MBL2, SST, CD40LG, IL4, VIP, CD79A
30rantes448.8IL4, CD40LG, CD4, MBL2, CCL11, IL1A
31genistein44 28 59 2 11 2413.7CXCL10, CD4, CCL5, CCL11, IL1A, SST
32propranolol44 28 49 11 2412.7CCL5, SST, LTF, TAC1, VIP
33neopterin448.7CD40LG, IL1A, IL4, CXCL10, CD79A, CD4
34levodopa44 119.7CAT, SST, SLC15A1, TAC1, LTF
35prostaglandin448.6VIP, IL1A, TAC1, PTGES3
36h2o2448.5CAT, VIP, LTF, CD79A, DHFR, TAC1
37fmlp448.5SLC15A1, CCL11, CCL5, CSF3, LTF, IL1A
38methacholine44 119.4LTF, VIP, TAC1, IL4, CD79A, CCL5
39actinomycin d448.4CCL11, CAT, TAC1, LTF, CD40LG, IL4
40heparin44 28 11 2411.3CD40LG, TAC1, CCL11, CD4, CD79A, IL1A
41alanine448.2SLC15A1, LTF, CXCL10, DHFR, CD4, VIP
42lactate448.1DHFR, CD79A, CD40LG, SST, VIP, CAT
43adenylate448.0CXCL10, IL4, DHFR, VIP, SST, LTF
44retinoic acid44 248.9SST, CXCL10, DHFR, CD79A, CCL11, CCL5
45epinephrine44 11 249.8IL1A, TAC1, CD79A, CD40LG, SST, CSF3
46cyclosporin a44 28 599.7LTF, CCL11, CD40LG, CD79A, CCL5, IL4
47dexamethasone44 49 28 1110.7VIP, PTGES3, TAC1, CD79A, CD40LG, LTF
48histamine44 28 249.5CCL5, CXCL10, SST, LTF, CD40LG, CD79A
49vegf447.2CCL5, CSF3, SST, CCL11, CD40LG, VIP
50cysteine447.1SLC15A1, TAC1, IL4, DHFR, CD79A, CD40LG

GO Terms for genes affiliated with Cryptosporidiosis

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Sources:
16Gene Ontology
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Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7CD4, CD40LG, CD79A, CXCL10, IL4
2extracellular regionGO:0055767.6CCL11, CCL5, MBL2, SST, LTF, CXCL10
3extracellular spaceGO:0056157.0TAC1, CCL11, CCL5, MBL2, CSF3, SST

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell activationGO:05086310.0CD4, CCL5
2eosinophil chemotaxisGO:0482459.9CCL5, CCL11
3positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, CD4
4B cell differentiationGO:0301839.7CD40LG, CD79A, IL4
5chemotaxisGO:0069359.6IL4, CXCL10, CCL5, CCL11
6B cell proliferationGO:0421009.6CD79A, CD40LG
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5CSF3, CAT, CCL5
8cell-cell signalingGO:0072679.0CCL5, SST, CXCL10, TAC1
9inflammatory responseGO:0069548.9TAC1, IL1A, CXCL10, CD40LG, CCL5, CCL11
10immune responseGO:0069558.8CCL11, CSF3, CD4, CXCL10, IL4, IL1A

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7IL1A, IL4, CD40LG, CSF3

Products for genes affiliated with Cryptosporidiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet