MCID: CRY003
MIFTS: 54

Cryptosporidiosis malady

Infectious, Gastrointestinal categories

Summaries for Cryptosporidiosis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to acquired immunodeficiency syndrome and toxoplasmosis. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Cytokines and Inflammatory Response and Rho Family GTPases. The drug nitazoxanide and the compounds hydrocortisone and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and small intestine, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:64 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 8 43 10 45 49 34 61
cryptosporidial gastroenteritis 8 61
infection by cryptosporidium 8
intestinal cryptosporidiosis 8


External Ids:

Disease Ontology8 DOID:1733
ICD9CM27 007.4
MeSH35 D003457
MESH via Orphanet36 D003457
ICD10 via Orphanet26 A07.2
SNOMED-CT via Orphanet58 240370009, 58777003
UMLS via Orphanet62 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome30.4DHFR, CD4
2toxoplasmosis30.2DHFR, CD79A, CD40LG, CD4
3graft versus host disease30.0IL4, CSF3, CCL5
4adenocarcinoma30.0TAC1, CXCL10, SST, CCL5, VIP
5crohn's disease29.8LTF
6ankylosing spondylitis29.8CD79A
7cd40 ligand deficiency29.8CD40LG
8acute leukemia29.8DHFR, CSF3
9colorectal cancer29.8DHFR, CD4, LTF
10pneumocystosis29.8DHFR, CD4
11sinusitis29.8CD79A, CD4, CCL11
12hepatitis c29.8IL4, CXCL10, CD40LG, LTF
13ulcerative colitis29.8SLC15A1, TAC1, IL1A, IL4, CXCL10, CD79A
14giardiasis10.5
15isosporiasis10.3
16sclerosing cholangitis10.2
17acute diarrhea10.1
18cyclosporiasis10.1
19n syndrome10.1
20acute graft versus host disease10.1
21mannose-binding lectin deficiency10.1
22somatostatin analog10.1
23kawasaki disease10.0MBL2
24rheumatic fever10.0MBL2
25keratoconjunctivitis10.0CCL11
26stomach cancer10.0MBL2
27dementia10.0CXCL10
28paracoccidioidomycosis10.0CXCL10
29neuritis10.0CCL5
30complex regional pain syndrome10.0TAC1
31schizophrenia10.0TAC1
32parkinson's disease10.0TAC1
33biliary atresia10.0CXCL10
34glioblastoma multiforme10.0TAC1
35severe acute respiratory syndrome10.0CXCL10
36sudden infant death syndrome10.0TAC1
37periodontitis10.0IL1A
38fanconi's anemia10.0DHFR
39keratoconjunctivitis sicca10.0LTF
40folliculitis10.0CCL11
41dermatomyositis10.0IL1A
42chorioamnionitis10.0LTF
43leprosy10.0CD4
44alopecia areata10.0IL1A
45retinitis10.0CD4
46leptospirosis10.0CD40LG
47alopecia10.0CD4
48myopathy10.0CD4
49pertussis10.0CD79A
50kidney cancer10.0CD4

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Clinical Features for Cryptosporidiosis

Drugs & Therapeutics for Cryptosporidiosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Search CenterWatch for Cryptosporidiosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cryptosporidiosis

Anatomical Context for Cryptosporidiosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cryptosporidiosis:

33
Liver, Lung, Small intestine, Colon, Breast, T cells

Animal Models for Cryptosporidiosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cryptosporidiosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.9TAC1
2MP:00053977.2CCL11, CCL5, MBL2, CSF3, LTF, CD4
3MP:00053876.4IL1A, VIP, CCL11, CCL5, MBL2, CSF3
4MP:00053765.9LTF, SST, MBL2, CAT, VIP, CD4

Publications for Cryptosporidiosis

Sources:
51PubMed
See all sources

Articles related to Cryptosporidiosis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Preventing cryptosporidiosis: the need for safe drinking water. (23599543)
2013
2
Retrospective Study of Cryptosporidiosis Among Diarrhoeic Children in the Arid Region of North-Eastern Nigeria. (24245998)
2013
3
Prevalence of cryptosporidiosis in dairy cattle, cattle-keeping families, their non-cattle-keeping neighbours and HIV-positive individuals in Dagoretti Division, Nairobi, Kenya. (22878888)
2012
4
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
5
A trans-disciplinary study on the health risks of cryptosporidiosis from dairy systems in Dagoretti, Nairobi, Kenya: study background and farming system characteristics. (22886442)
2012
6
Effect of immunosuppression on the course of cryptosporidiosis experimentally. (23469638)
2012
7
Molecular epidemiology, spatiotemporal analysis, and ecology of sporadic human cryptosporidiosis in Australia. (21908628)
2011
8
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
9
The impact of climate variability and change on cryptosporidiosis and giardiasis rates in New Zealand. (20375485)
2010
10
Cryptosporidiosis in paediatric renal transplantation. (19714369)
2009
11
A tale of two parasites: the comparative epidemiology of cryptosporidiosis and giardiasis. (19393124)
2009
12
Spatial analysis of notified cryptosporidiosis infections in Brisbane, Australia. (19648028)
2009
13
Cryptosporidiosis from a community swimming pool: outbreak investigation and follow-up study. (19426570)
2009
14
Classification of Cryptosporidium species from patients with sporadic cryptosporidiosis by use of sequence-based multilocus analysis following mutation scanning. (18448696)
2008
15
Activity of an anti-inflammatory drug against cryptosporidiosis in neonatal lambs. (18579312)
2008
16
An outbreak of cryptosporidiosis at a day-care centre in Sweden. (17868622)
2007
17
Clinical features & risk factors associated with cryptosporidiosis in HIV infected adults in India. (18219083)
2007
18
Is nitazoxanide an effective treatment for patients with acquired immune deficiency syndrome-related cryptosporidiosis? (17245327)
2007
19
An outbreak of cryptosporidiosis suspected to be related to contaminated food, October 2006, Sakai City, Japan. (18032847)
2007
20
Cryptosporidiosis. (17626307)
2007
21
Cryptosporidiosis surveillance and water-borne outbreaks in Europe. (17991392)
2007
22
Cryptosporidiosis decline after regulation, England and Wales, 1989-2005. (17553283)
2007
23
Pulmonary cryptosporidiosis: role of COX2 and NF-kB. (17004971)
2006
24
Zoonotic cryptosporidiosis in man and animal in farms, Giza Governorate, Egypt. (17366871)
2006
25
Recurrent outbreaks of cryptosporidiosis associated with calves among students at an educational farm programme, Minnesota, 2003. (16672084)
2006
26
Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. (16804841)
2006
27
Cryptosporidium and cryptosporidiosis in Denmark--current status. (16252473)
2005
28
Cryptosporidiosis in HIV-infected Venezuelan adults is strongly associated with acute or chronic diarrhea. (16014832)
2005
29
An outbreak of cryptosporidiosis in Wales, November 2005. (16794291)
2005
30
Serological detection of cryptosporidiosis among Filipino cancer patients. (16237576)
2005
31
Relationship of cryptosporidiosis to abdominal pain and diarrhea in Mayan Indians. (15361977)
2004
32
Prevalence and control of bovine cryptosporidiosis in German dairy herds. (12623207)
2003
33
Gastrointestinal cryptosporidiosis in a puppy. (12935734)
2003
34
Apparent rarity of cryptosporidiosis in human immunodeficiency virus (HIV)-related diarrhoea in Enugu, South-Eastern, Nigeria. (12163876)
2002
35
Enhancing surveillance of cryptosporidiosis: test all faecal specimens from children. (12166295)
2002
36
Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis. (11796330)
2002
37
Cryptosporidiosis and the challenges of chemotherapy. (12127863)
2002
38
Increased risk of cryptosporidiosis from private water supplies. (11525007)
2001
39
An outbreak of cryptosporidiosis in an urban swimming pool: why are such outbreaks difficult to detect? (10937403)
2000
40
Cryptosporidiosis in birds--a review. (10669097)
2000
41
Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children. (10653343)
2000
42
Confirmation of the prophylactic value of paromomycin in a natural outbreak of caprine cryptosporidiosis. (10703755)
2000
43
An outbreak of cryptosporidiosis linked to a foodhandler. (10669357)
2000
44
Urinary tract cryptosporidiosis in commercial laying hens. (10879932)
2000
45
Modelling the impact of prior immunity, case misclassification and bias on case-control studies in the investigation of outbreaks of cryptosporidiosis. (11218222)
2000
46
Serological analysis of a cryptosporidiosis epidemic. (10817139)
2000
47
Case of cryptosporidiosis in an Iraqi woman with ulcerative colitis. (10793796)
1999
48
International workshop. Microsporidiosis and cryptosporidiosis in immunodeficient patients. September 28-October 1, 1993, CeskAc BudA9jovice, Czech Republic. Proceedings. (8013923)
1993
49
Sarcocystosis, toxoplasmosis, and cryptosporidiosis in cattle. (3089550)
1986
50
Cryptosporidiosis in Venezuelan children with acute diarrhea. (4040717)
1985

Genetic Variations for Cryptosporidiosis

Expression for genes affiliated with Cryptosporidiosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CD4
2
Hide members
10.0CXCL10, CD4
39.9CD79A, CD4
49.8CCL11, CCL5, CXCL10
59.7IL4, CXCL10, CCL11
69.6IL4, CD40LG, CCL11
79.2CCL5, CD4, CD79A, IL4
8
Hide members
9.1CCL11, CCL5, CD4, IL4, IL1A
9
Hide members
9.0CCL11, CD4, CD40LG, IL4, IL1A
109.0CSF3, CD4, IL4, IL1A
11
Hide members
9.0CCL11, CCL5, CSF3, CD4, CXCL10
12
Hide members
8.9IL1A, CXCL10, CD4, CSF3, CCL11
13
Hide members
8.9IL1A, IL4, CD79A, CD40LG, CD4
14
Hide members
8.8TAC1, CXCL10, SST, CCL5, CCL11
15
Hide members
8.3CXCL10, CD4, CSF3, CCL5, CCL11, IL4

Compounds for genes affiliated with Cryptosporidiosis

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1hydrocortisone45 2 60 1113.6LTF
2endotoxin4510.1CSF3, LTF
3cycloheximide459.9CXCL10, CAT, CD4
4pneumococcal459.8LTF, CD79A, CD40LG, DHFR
5glutamate459.8TAC1, CD40LG, SLC15A1
6mannan459.7CD4, MBL2, CD79A
7pmma459.6CD40LG, CD79A, CCL5, LTF
8indomethacin45 60 29 1112.6VIP, LTF, TAC1
9hemocyanin459.5CD40LG, CD79A, IL4, CD4
10lactose45 1110.5MBL2, SST, LTF, DHFR, CD40LG
11estrogen459.5CD79A, TAC1, MBL2, LTF
12norepinephrine45 11 2411.5VIP, TAC1, LTF
13polymyxin b459.4MBL2, IL4, IL1A, LTF
14allergens459.4IL4, CXCL10, CD79A, CD40LG, CCL11
15ccl345 2910.3IL1A, CCL5, CSF3, CCL11, CXCL10
16n-formylmethionyl-leucylphenylalanine459.3CCL11, CSF3, IL1A, LTF, SLC15A1
17pertussis459.3SST, CCL5, LTF, CCL11, VIP
18tarc459.3IL1A, IL4, CXCL10, CD4, CCL5, CCL11
19chloroquine45 2 50 29 1113.2CD4, IL4, CXCL10, DHFR, CD79A
20isoproterenol45 1110.2IL1A, TAC1, LTF, SST
21pge2459.2PTGES3, CD4, CCL11, SST
22anti-fungal459.1MBL2, CSF3, LTF, CD40LG, CD79A, DHFR
23ribavirin45 50 1111.1CSF3, MBL2, LTF, CXCL10, IL4, CD40LG
24leukotriene b445 60 2411.0CCL11, CCL5, LTF, IL1A, CXCL10
25cyclophosphamide45 50 1110.9TAC1, DHFR, SST, CSF3, MBL2
26polyethylene glycol458.9IL4, CD79A, VIP, CD40LG, IL1A
27captopril45 29 50 60 1112.9SLC15A1, TAC1, VIP, SST, CD79A
28n acetylcysteine458.8CD40LG, CCL11, CCL5, CAT, LTF, CD79A
29thyroxine45 249.8MBL2, SST, CD40LG, IL4, VIP, CD79A
30rantes458.8IL4, CD40LG, CD4, MBL2, CCL11, IL1A
31genistein45 29 60 2 11 2413.7CXCL10, CD4, CCL5, CCL11, IL1A, SST
32propranolol45 29 50 11 2412.7CCL5, SST, LTF, TAC1, VIP
33neopterin458.7CD40LG, IL1A, IL4, CXCL10, CD79A, CD4
34levodopa45 119.7CAT, SST, SLC15A1, TAC1, LTF
35prostaglandin458.6VIP, IL1A, TAC1, PTGES3
36h2o2458.5CAT, VIP, LTF, CD79A, DHFR, TAC1
37fmlp458.5SLC15A1, CCL11, CCL5, CSF3, LTF, IL1A
38methacholine45 119.4LTF, VIP, TAC1, IL4, CD79A, CCL5
39actinomycin d458.4CCL11, CAT, TAC1, LTF, CD40LG, IL4
40heparin45 29 11 2411.3CD40LG, TAC1, CCL11, CD4, CD79A, IL1A
41alanine458.2SLC15A1, LTF, CXCL10, DHFR, CD4, VIP
42lactate458.1DHFR, CD79A, CD40LG, SST, VIP, CAT
43adenylate458.0CXCL10, IL4, DHFR, VIP, SST, LTF
44retinoic acid45 248.9SST, CXCL10, DHFR, CD79A, CCL11, CCL5
45epinephrine45 11 249.8IL1A, TAC1, CD79A, CD40LG, SST, CSF3
46cyclosporin a45 29 609.7LTF, CCL11, CD40LG, CD79A, CCL5, IL4
47dexamethasone45 50 29 1110.7VIP, PTGES3, TAC1, CD79A, CD40LG, LTF
48histamine45 29 249.5CCL5, CXCL10, SST, LTF, CD40LG, CD79A
49vegf457.2CCL5, CSF3, SST, CCL11, CD40LG, VIP
50cysteine457.1SLC15A1, TAC1, IL4, DHFR, CD79A, CD40LG

GO Terms for genes affiliated with Cryptosporidiosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7CD4, CD40LG, CD79A, CXCL10, IL4
2extracellular regionGO:0055767.6CCL11, CCL5, MBL2, SST, LTF, CXCL10
3extracellular spaceGO:0056157.0TAC1, CCL11, CCL5, MBL2, CSF3, SST

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell activationGO:05086310.0CD4, CCL5
2eosinophil chemotaxisGO:0482459.9CCL5, CCL11
3positive regulation of interleukin-2 biosynthetic processGO:0450869.9IL1A, CD4
4B cell differentiationGO:0301839.7CD40LG, CD79A, IL4
5chemotaxisGO:0069359.6IL4, CXCL10, CCL5, CCL11
6B cell proliferationGO:0421009.6CD79A, CD40LG
7positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.5CSF3, CAT, CCL5
8cell-cell signalingGO:0072679.0CCL5, SST, CXCL10, TAC1
9inflammatory responseGO:0069548.9TAC1, IL1A, CXCL10, CD40LG, CCL5, CCL11
10immune responseGO:0069558.8CCL11, CSF3, CD4, CXCL10, IL4, IL1A

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7IL1A, IL4, CD40LG, CSF3

Products for genes affiliated with Cryptosporidiosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet