Summaries for Cryptosporidiosis

Sources:
6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention23

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis (disorder), is related to hepatitis c and immunodeficiency. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and RAR-Gamma-RXR-Alpha Degradation. The drugs nitazoxanide and paromomycin sulfate and the compounds ionomycin and budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.6

CDC: Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."2

Wikipedia: Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan...44 more...

Aliases & Descriptions for Cryptosporidiosis

Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 23MedlinePlus, 2CDC, 43UMLS, 40SNOMED-CT, 19ICD9CM, 24MeSH
See all sources

Aliases & Descriptions:

cryptosporidiosis 6 30 8 32 23 43
cryptosporidial gastroenteritis (disorder) 6
infection by cryptosporidium (disorder) 6
cryptosporidial gastroenteritis 43
intestinal cryptosporidiosis 6
cryptosporidiosis (disorder) 6
infection 43

External Ids:

ICD9CM19 007.4

Related Diseases for Cryptosporidiosis

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to cryptosporidiosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1453)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c36.7CD40LG, IL4, LTF, CXCL10
2immunodeficiency36.2CD4, CD40LG, IL4, MBL2, LTF, CXCL10
3hepatitis b36.0MBL2, CAT, CXCL10
4cytomegalovirus infection32.8CD40LG, IL4, MBL2, CCL5, CSF3
5malaria32.5CD40LG, IL1A, IL4
6hepatitis31.6CD4, CD40LG, IL1A, IL4, MBL2, CCL11
7herpes simplex30.8CD4, CD40LG, IL4, MBL2, CCL5, CAT
8intrauterine infections30.7IL1A, IL4, LTF
9asthma30.7IL4, CCL11, CCL5
10insulin resistance30.3CD40LG, MBL2, CCL11, CAT, TAC1, CXCL10
11west nile virus30.3CD40LG, CCL5, CXCL10
12bronchitis30.1CCL11, LTF, TAC1
13hepatitis a29.9CD4, CD40LG, CAT
14severe acute respiratory syndrome29.7CD4, IL4, MBL2, CCL5, CXCL10
15duodenal ulcer29.7CD40LG, MBL2, CCL5, CAT
16pulmonary tuberculosis29.7IL4, MBL2, CAT
17vaccinia29.6CD4, IL1A, IL4, CXCL10
18sepsis29.5IL1A, MBL2, LTF, CSF3
19vaginitis29.4IL1A, IL4, MBL2, CCL5, LTF
20endocarditis29.3CD40LG, IL1A, MBL2, CAT
21cryoglobulinemia29.3CD40LG, IL4, CXCL10
22japanese encephalitis29.2CD40LG, IL4, CXCL10
23q fever29.2CD40LG, IL4, MBL2, CCL5
24tuberculosis29.0CD4, CD40LG, IL1A, IL4, MBL2, CCL11
25bcg infection28.9IL4, CXCL10
26t-cell leukemia28.9CD40LG, IL1A, IL4, MBL2, CCL5, CAT
27hepatocellular carcinoma28.8CD4, IL1A, IL4, MBL2, CCL5, CAT
28coccidioidomycosis28.8CD4, MBL2
29haemophilus influenzae28.8IL1A, CAT, LTF
30cervicitis28.7CD4, IL1A, IL4, MBL2, CCL5, CAT
31neutropenia28.7CD40LG, IL1A, MBL2, LTF, CXCL10, CSF3
32acquired immunodeficiency syndrome28.7CD4, CCL11, CCL5, TAC1, DHFR, CXCL10
33influenza28.7CD4, CD40LG, IL1A, IL4, MBL2, CCL11
34hemophilia28.6CD4, CD40LG, IL4
35measles28.6CD4, CD40LG, IL1A, IL4, CCL5, CAT
36vulvovaginitis28.6IL4, MBL2, LTF
37toxoplasmosis28.5CD4, CD40LG, IL4, DHFR
38systemic lupus erythematosus28.5CD4, CD40LG, IL4, MBL2, CCL5, LTF
39atopy28.4IL1A, IL4, MBL2, CCL11, CCL5
40chronic granulomatous disease28.3CD40LG, CAT, LTF, CSF3
41subacute sclerosing panencephalitis28.2IL4, CCL5, CXCL10
42rubella28.2CD40LG, IL4, CAT
43plasmodium falciparum malaria28.1MBL2, CCL5, DHFR
44kaposi's sarcoma28.1CD4, IL1A, IL4, CAT, DHFR, CXCL10
45encephalitis28.1CD4, CD40LG, IL4, CCL5, CAT, LTF
46vulvovaginal candidiasis28.1IL4, MBL2
47pneumonia28.0CD4, CD40LG, IL1A, IL4, MBL2, CCL11
48gastric ulcer28.0CCL5, CAT, PTGES3, LTF
49onchocerciasis28.0IL4, CCL11, CCL5
50gastritis28.0CD4, CD40LG, IL1A, IL4, MBL2, CCL5

Graphical network of the top 20 diseases related to cryptosporidiosis:



Graphical network of diseases related to cryptosporidiosis

Clinical Features for Cryptosporidiosis

Drugs & Therapeutics for Cryptosporidiosis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for cryptosporidiosis

Drug clinical trials:

Search ClinicalTrials for cryptosporidiosis

Search NIH Clinical Center for cryptosporidiosis

Search CenterWatch for cryptosporidiosis

Inferred drug relations via UMLS/NDF-RT:

43 28 nitazoxanide, paromomycin, paromomycin sulfate

Genetic Tests for Cryptosporidiosis

Anatomical Context for Cryptosporidiosis

Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to cryptosporidiosis:

22
Lung

Phenotypes for genes affiliated with Cryptosporidiosis

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to cryptosporidiosis:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:00053979.2CCL11, CSF3
2immune system phenotypeMP:00053879.0CD4, MBL2, LTF, CXCL10
3homeostasis/metabolism phenotypeMP:00053767.7PTGES3, CAT, MBL2, IL1A, CD40LG, CD4

Publications for genes affiliated with Cryptosporidiosis

Sources:
35PubMed
See all sources

Articles related to cryptosporidiosis:

idTitleAuthorsYearAffiliating Genes
1High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. (17043107)Wang H.C.... White A.C.2007CCL11, CCL5, IL1A
2Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. (16804841)Kirkpatrick B.D.... Sears C.L.2006MBL2
3Association of mannose-binding lectin deficiency with cryptosporidiosis. (16804842)Wanyiri J.... Ward H.2006MBL2
4Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. (12685639)Alcantara C.S.... Guerrant R.L.2003LTF
5Substance P expression correlates with severity of diarrhea in cryptosporidiosis. (12854086)Robinson P.... White A.C.2003TAC1
6Serum cytokines as predictors of clinical outcome in AIDS-related intestinal cryptosporidiosis. (9675651)Cacopardo B.... Nunnari A.1998IL4
7Reactive oxygen metabolites in piglet cryptosporidiosis. (9098854)Argenzio R.A.... Rhoads J.M.1997CAT
8Human cryptosporidiosis: detection of specific antibo dies in the serum by an indirect immunofluorescence. (9269088)Braz L.M.... Andrade JA_nior H.F.1996CD40LG

Expression for genes affiliated with Cryptosporidiosis

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Pathways for genes affiliated with Cryptosporidiosis

Sources:
10EMD Millipore, 36QIAGEN, 20KEGG, 41Thomson Reuters
See all sources

Pathways related to cryptosporidiosis according to GeneDecks:

(show all 30)
idPathwayScoreTop Affiliating Genes
1Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response109.8CCL11, CXCL10
2RAR-Gamma-RXR-Alpha Degradation369.5CCL11, CCL5, CSF3
3Molecular Mechanisms of Cancer369.5CCL5, CCL11, CD4
4Asthma209.0CD40LG, IL4, CCL11
5Immune response_TLR signaling pathways418.7CXCL10, CCL11, IL4
6T cell receptor signaling pathway208.7CD4, CD40LG, IL4
7Akt Signaling368.5CXCL10, CCL5, CCL11, IL4, CD4
8NFAT Signaling and Lymphocyte Interactions368.4CCL5, CCL11, IL4, IL1A, CD4
9PGC1Alpha Pathway368.4CCL5, CCL11, IL4, IL1A, CD4
10SOCS Pathway368.3CCL5, CCL11, IL4, IL1A, CD4
11Hematopoietic cell lineage208.3CD4, IL1A, IL4, CSF3
12Regulation of eIF4 and p70S6K368.3CCL5, CCL11, IL4, IL1A, CD4
13Glucocorticoid Receptor Signaling368.3CD4, IL1A, IL4, CCL11, CCL5
14TGF-Beta Pathway368.3CCL5, CCL11, IL4, IL1A, CD4
15MAPK Family Pathway368.2CCL5, CCL11, IL4, IL1A, CD4
16JAK-STAT Pathway368.1CD4, IL1A, IL4, CCL11, CCL5
17Tec Kinases Signaling368.1CCL5, CCL11, IL4, IL1A, CD4
18MIF Mediated Glucocorticoid Regulation368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
19MIF Regulation of Innate Immune Cells368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
20all-trans-Retinoic Acid Signaling in Brain368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
21PEDF Induced Signaling368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
22IL-6 Pathway368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
23Endothelin-1 Signaling Pathway368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
24PAK Pathway368.0CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
25Rho Family GTPases367.9CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
26ERK Signaling367.8CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
27Cytokine-cytokine receptor interaction207.6CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
28STAT3 Pathway367.5CD4, CSF3, CXCL10, CCL5, CCL11, IL4
29Antioxidant Action of Vitamin-C367.5CSF3, CXCL10, CCL5, CCL11, IL4, IL1A
30p38 Signaling367.5CSF3, CXCL10, CCL5, CCL11, IL4, IL1A

Compounds for genes affiliated with Cryptosporidiosis

Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 34PharmGKB, 18HMDB
See all sources

Compounds related to cryptosporidiosis according to GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1ionomycin32 10.4CCL11
2budesonide32 42 9 9 13.2CCL11, LTF
3n acetylcysteine32 10.2LTF, CCL11
4cyclophosphamide32 34 9 9 13.0TAC1, LTF, MBL2
5lactose32 9 9 11.7DHFR, LTF, CD40LG
6pneumococcal32 9.6CD40LG, DHFR, LTF
7estrogen32 9.6LTF, CXCL10, TAC1, PTGES3
8amoxicillin32 9 9 11.5SLC15A1, LTF, CD40LG
9groalpha32 9.5CXCL10, CCL11, IL1A, CCL5
10heparin32 9 18 9 12.4CCL5, TAC1, CD4, CCL11
11endotoxin32 9.3LTF, CCL11, CXCL10, CSF3
12glutamate32 9.2CD4, TAC1, DHFR, SLC15A1, CCL5
13leukotriene b432 42 18 11.1IL1A, CCL5, CCL11, LTF, CXCL10
14prostaglandin32 9.1PTGES3, CCL5, TAC1, IL1A, CCL11
15pranlukast32 9 9 11.1CCL5, IL4, CCL11
16fluticasone propionate32 42 9 9 12.1IL4, CCL11, CCL5, CXCL10
17polymyxin b32 9.0LTF, MBL2, IL4, IL1A
18poly(i-c)32 9.0IL4, CCL11, CCL5, CXCL10
19anti-fungal32 9.0MBL2, CSF3, CD40LG, LTF, DHFR
20il 1032 8.9CXCL10, CCL5, IL4, IL1A
21ccl332 8.9CCL11, IL1A, CSF3, CXCL10, CCL5
22n-formylmethionyl-leucylphenylalanine32 8.9CSF3, SLC15A1, CCL11, IL1A, LTF
23hypoxanthine32 9 18 9 11.8CAT, IL4, LTF, DHFR
24zidovudine32 9 9 10.8CSF3, SLC15A1, CD4, DHFR
25methacholine32 9 9 10.8LTF, TAC1, CCL5, CCL11, IL4
26cysteine32 8.7CCL5, SLC15A1, CD4, CD40LG, LTF, DHFR
27ganciclovir32 9 9 10.7CSF3, SLC15A1, DHFR, IL4
28gm-csf32 8.7IL4, CCL5, IL1A, CSF3
29allergens32 8.6CXCL10, IL4, CD40LG, CCL11
30hydrocortisone32 9 9 10.6IL1A, IL4, CCL5, LTF, CXCL10
31pge232 8.4CD4, IL1A, CCL11, CCL5, PTGES3, LTF
32genistein32 9 18 9 11.3CD4, CD40LG, IL1A, CCL11, CCL5, CXCL10
33chloroquine32 34 9 9 11.3IL4, CD4, DHFR, CXCL10
34fmlp32 8.3SLC15A1, LTF, IL1A, CCL11, CCL5, TAC1
35pdtc32 8.3IL1A, CCL5, CAT, IL4
36herbimycin a32 42 9.3CCL11, IL1A, CD40LG, CD4, IL4
37tarc32 8.2IL4, IL1A, CXCL10, CCL5, CCL11, CD4
38ribavirin32 34 9 9 11.1CXCL10, LTF, MBL2, IL4, CD40LG, CSF3
39chloramphenicol32 9 9 10.0IL4, CD4, DHFR, LTF, CAT
40histamine32 18 9.0CD40LG, IL4, CCL5, LTF, CCL11, TAC1
41alanine32 8.0CD40LG, CCL11, SLC15A1, CXCL10, CCL5, DHFR
42neopterin32 7.8CD4, CD40LG, IL1A, IL4, MBL2, LTF
43actinomycin d32 7.7CCL11, CAT, IL4, IL1A, CD40LG, LTF
44retinoic acid32 42 18 9.7CSF3, CD40LG, IL1A, CXCL10, DHFR, LTF
45indomethacin32 9 9 9.4IL1A, IL4, CCL11, CAT, LTF, CCL5
46cyclosporin a32 42 8.3IL4, IL1A, CD40LG, SLC15A1, CCL11, CSF3
47cycloheximide32 7.3CD4, CSF3, CXCL10, CAT, CCL5, IL4
48vegf32 7.0CD40LG, MBL2, CXCL10, LTF, CSF3, CCL11
49rantes32 6.9MBL2, CD4, CD40LG, IL1A, IL4, CSF3
50dexamethasone32 42 34 9 9 10.5IL4, MBL2, CCL11, CCL5, PTGES3, LTF

GO Terms for genes affiliated with Cryptosporidiosis

Sources:
12Gene Ontology
See all sources

Cellular components related to cryptosporidiosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2IL1A, MBL2, CCL11, CCL5, LTF, TAC1
2external side of plasma membraneGO:0098978.1CXCL10, IL4, CD40LG, CD4
3extracellular spaceGO:0056156.6CD40LG, CSF3, CXCL10, TAC1, CCL5, CCL11

Biological processes related to cryptosporidiosis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:0482459.9CCL5, CCL11
2regulation of T cell activationGO:0508639.7CD4, CCL5
3chronic inflammatory responseGO:0025449.7CCL5, CCL11
4positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD4, IL1A
5positive regulation of MHC class II biosynthetic processGO:0453489.2IL4, CD40LG
6positive regulation of angiogenesisGO:0457669.1IL1A, CCL11, CCL5
7chemotaxisGO:0069358.8CXCL10, CCL5, CCL11, IL4
8inflammatory responseGO:0069548.6CD40LG, IL1A, CCL11, CCL5, TAC1, CXCL10
9immune responseGO:0069557.7CSF3, CXCL10, CCL11, IL4, IL1A, CD4

Molecular functions related to cryptosporidiosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.5CCL11, CCL5, CXCL10
2cytokine activityGO:0051257.9CD40LG, IL1A, IL4, CSF3

Sources for Cryptosporidiosis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS