MCID: CRY003
MIFTS: 64

Cryptosporidiosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories
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Summaries for Cryptosporidiosis

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MedlinePlus:33 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards based summary: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to microsporidiosis and gastroenteritis. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and IL4-mediated signaling events. The drug nitazoxanide and the compounds pneumococcal and pertussis have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and normal.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:65 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Cryptosporidiosis, Aliases & Descriptions:

Name: Cryptosporidiosis 8 42 10 44 48 33 62
Cryptosporidial Gastroenteritis 8 62
 
Infection by Cryptosporidium 8 62
Intestinal Cryptosporidiosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:1733
ICD9CM27 007.4
MeSH34 D003457
MESH via Orphanet35 D003457
ICD10 via Orphanet26 A07.2
UMLS via Orphanet63 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

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Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1microsporidiosis31.2CD4
2gastroenteritis30.7CD79A
3intestinal disease30.6SST
4pancreatitis30.5LTF, TAC1, SST
5pneumocystosis30.4CD4, DHFR
6diarrhea30.4VIP, SST, TAC1, CD4, CD79A, LTF
7toxoplasmosis30.3CD40LG, CD79A, CD4, DHFR
8shigellosis30.3CD79A, LTF
9chickenpox30.3CD4, CD79A
10adenocarcinoma30.2VIP, CXCL10, SST, CCL5, TAC1
11acute graft versus host disease30.1CSF3, IL4
12graft versus host disease30.1CCL5, IL4, CSF3
13colitis30.1LTF, IL4, DHFR, CXCL10
14candidiasis30.0CD4, CD79A, LTF
15hepatitis29.9CXCL10, CCL11, CAT, CD4, CD40LG
16hepatitis c29.8CXCL10, IL4, CD40LG, LTF
17influenza29.4CXCL10, CCL5, CCL11, MBL2, CD4, CD79A
18gastritis29.3SST, CCL5, CAT, CD4, CD79A, LTF
19myeloma29.1DHFR, IL4, CSF3, CD4, CD79A, CD40LG
20ulcerative colitis28.9VIP, CXCL10, CCL11, IL4, IL1A, TAC1
21leukemia28.1DHFR, CCL11, IL4, IL1A, CSF3, CAT
22folliculitis10.6CCL11
23rheumatic congestive heart failure10.6MBL2
24keratoconjunctivitis10.6CCL11
25giardiasis10.5
26keratopathy10.5TAC1
27keratoconjunctivitis sicca10.5LTF
28meningococcemia10.5CCL5
29q fever10.5CD79A
30conjunctivitis10.5CD79A
31lactose intolerance10.5LTF
32urethritis10.5CD79A
33cryptococcosis10.5CD4
34histoplasmosis10.5CD4
35poems syndrome10.5CD79A
36bronchiolitis10.5CCL5, CCL11
37listeriosis10.5CD4
38macroglobulinemia10.4CD79A
39exanthem10.4CD79A
40viral meningitis10.4CXCL10, CCL5
41eosinophilic pneumonia10.4CCL5, CCL11
42bronchitis10.4CD79A
43pancreatic cholera10.4VIP, SST
44polyarteritis nodosa10.4LTF
45wdha syndrome10.4VIP, SST
46pancreatic islet cell tumors10.4VIP, SST
47giant papillary conjunctivitis10.4CCL11, LTF
48endocrine gland cancer10.4VIP, SST
49somatostatinoma10.4VIP, SST
50vipoma10.4SST, VIP

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Symptoms for Cryptosporidiosis

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Drugs & Therapeutics for Cryptosporidiosis

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Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cryptosporidiosis

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Anatomical Context for Cryptosporidiosis

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MalaCards organs/tissues related to Cryptosporidiosis:

32
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

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MGI Mouse Phenotypes related to Cryptosporidiosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD40LG, CD79A, MBL2, TAC1, CSF3, IL4
2MP:00028737.3VIP, SST, CCL11, IL4, TAC1, CD4
3MP:00053976.7CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
4MP:00053766.7IL4, SST, CXCL10, VIP, IL1A, CAT
5MP:00053876.3LTF, VIP, CXCL10, SST, CCL5, CCL11

Publications for Cryptosporidiosis

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Articles related to Cryptosporidiosis:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
2014
2
Molecular characterization of Cryptosporidium parvum isolates from human cryptosporidiosis cases in Scotland. (25244937)
2014
3
Cryptosporidiosis and Isosporiasis among HIV-positive individuals in south Ethiopia: a cross sectional study. (24559235)
2014
4
Intestinal cryptosporidiosis in a 6-year-old child with alpha1-antitrypsin deficiency. (25072949)
2014
5
Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. (22877562)
2013
6
Human cryptosporidiosis caused by Cryptosporidium tyzzeri and C. parvum isolates presumably transmitted from wild mice. (23100342)
2013
7
Prevalence of cryptosporidiosis in dairy cattle, cattle-keeping families, their non-cattle-keeping neighbours and HIV-positive individuals in Dagoretti Division, Nairobi, Kenya. (22878888)
2012
8
Cryptosporidiosis-an overview. (22685452)
2012
9
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
10
Cryptosporidiosis surveillance--United States, 2009-2010. (22951493)
2012
11
Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. (22247151)
2012
12
Therapy and prevention of cryptosporidiosis in animals. (22521978)
2012
13
Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples. (21929875)
2011
14
Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. (21734132)
2011
15
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
16
Cryptosporidiosis in the elderly population of the United States. (19199827)
2009
17
High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. (19954529)
2009
18
A hospital-based serological survey of cryptosporidiosis in the Republic of Korea. (19724694)
2009
19
A Bayesian evaluation of four immunological assays for the diagnosis of clinical cryptosporidiosis in calves. (17493849)
2008
20
Cryptosporidiosis in buffalo calves (Bubalus bubalis): prevalence and potential risk factors. (18575969)
2008
21
Development of fluorescent in situ hybridization for Cryptosporidium detection reveals zoonotic and anthroponotic transmission of sporadic cryptosporidiosis in Sydney. (18789979)
2008
22
Microscopy for cryptosporidiosis screening in remote areas. (18445972)
2008
23
An outbreak of cryptosporidiosis at a day-care centre in Sweden. (17868622)
2007
24
First reported waterborne outbreak of cryptosporidiosis with Cyclospora co-infection in Turkey. (17370959)
2007
25
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
26
Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. (16886154)
2006
27
Effects of weather and river flow on cryptosporidiosis. (16459850)
2005
28
Cryptosporidium and cryptosporidiosis in Denmark--current status. (16252473)
2005
29
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
30
Cryptosporidiosis leading to an unsuspected diagnosis of AIDS. (15460500)
2004
31
Cryptosporidiosis in children in a north Jordanian paediatric hospital. (16335640)
2004
32
Disseminated cryptosporidiosis in Turkey: case report. (15250630)
2003
33
Foot and mouth disease in livestock and reduced cryptosporidiosis in humans, England and Wales. (12533277)
2003
34
Electrophoretic analysis of genetic variability within Cryptosporidium parvum from imported and autochthonous cases of human cryptosporidiosis in the United Kingdom. (12732542)
2003
35
Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosis. (13130414)
2003
36
An outbreak of cryptosporidiosis associated with an animal nursery at a regional fair. (12926737)
2003
37
Prevalence and control of bovine cryptosporidiosis in German dairy herds. (12623207)
2003
38
Cryptosporidiosis. (12686887)
2002
39
Novel cryptosporidium genotypes in sporadic cryptosporidiosis cases: first report of human infections with a cervine genotype. (11927023)
2002
40
PCR-ELISA: a new simplified tool for tracing the source of cryptosporidiosis in HIV-positive patients. (11763435)
2001
41
From the Centers for Disease Control and Prevention. Protracted outbreaks of cryptosporidiosis associated with swimming pool use--Ohio and Nebraska, 2000. (11439938)
2001
42
Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in suckling calves. (11232925)
2001
43
Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis. (11518676)
2001
44
Compliance with advice to boil drinking water during an outbreak of cryptosporidiosis. Outbreak Investigation Team. (10902259)
2000
45
Emerging public health concerns regarding cryptosporidiosis. (10976295)
2000
46
Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. (10669358)
2000
47
Role of the enteric nervous system in piglet cryptosporidiosis. (8968331)
1996
48
Coccidiosis and cryptosporidiosis in sheep and goats. (2245367)
1990
49
Mycobacterium marinum infection in a patient with cryptosporidiosis and the acquired immunodeficiency syndrome. (3203532)
1988
50
Cryptosporidiosis and isosporiasis in patients with AIDS. (3060532)
1988

Variations for Cryptosporidiosis

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Expression for genes affiliated with Cryptosporidiosis

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Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

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Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CCL11, CCL5, CXCL10
29.4CCL11, IL4, CD40LG
39.4IL1A, IL4, CXCL10
49.4CD4, CD79A, CD40LG
5
Show member pathways
9.3CD40LG, IL1A, IL4
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2CXCL10, CCL11, IL4, IL1A
7
Show member pathways
9.1CXCL10, CCL5, IL4, IL1A
89.0SST, IL1A, TAC1
98.9CD79A, CD4, IL4, CCL5
10
Show member pathways
8.7CCL5, CCL11, IL4, IL1A, CD4
118.7IL4, IL1A, CSF3, CD4
128.7CD4, CSF3, IL1A, IL4
13
Show member pathways
8.7CCL11, IL4, IL1A, CD4, CD40LG
14
Show member pathways
8.6CXCL10, SST, CCL5, CCL11, TAC1
15
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.5IL4, IL1A, CD4, CD79A, CD40LG
16
Show member pathways
8.4CXCL10, SST, CCL5, CCL11, TAC1, VIP
17
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
18
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
19
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
20
Show member pathways
7.7CD40LG, CXCL10, CCL5, CCL11, IL4, IL1A

Compounds for genes affiliated with Cryptosporidiosis

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Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 232)
idCompoundScoreTop Affiliating Genes
1pneumococcal449.6CD79A, LTF, DHFR, CD40LG
2pertussis449.5CCL11, VIP, CCL5, LTF, SST
3lactose44 1110.4LTF, CD40LG, DHFR, MBL2, SST
4pmma449.3CD40LG, LTF, CCL5, CD79A
5ccl344 2810.2CXCL10, CCL5, CCL11, CSF3, IL1A
6hemocyanin449.1CD4, CD40LG, CD79A, IL4
7allergens449.1CXCL10, CD40LG, CD79A, IL4, CCL11
8leukotriene b444 61 2411.1LTF, IL1A, CCL11, CCL5, CXCL10
9anti-fungal448.9DHFR, CSF3, MBL2, CD79A, CD40LG, LTF
10tarc448.9CXCL10, CD4, IL1A, IL4, CCL11, CCL5
11chloroquine44 2 50 28 1112.9CD79A, IL4, CXCL10, DHFR, CD4
12hydrocortisone44 2 61 1111.9LTF, SST, CCL5, IL1A, IL4, CXCL10
13thyroxine44 249.9CD79A, VIP, MBL2, SST, CD40LG, IL4
14mannan448.9MBL2, CD79A, CD40LG, CD4
15captopril44 61 50 28 1112.8VIP, SST, TAC1, IL1A, CD79A
16polyethylene glycol448.8VIP, CD79A, IL4, CD40LG, IL1A
17ribavirin44 50 1110.7IL4, CXCL10, LTF, MBL2, CSF3, CD40LG
18propranolol44 28 50 24 1112.7CCL5, VIP, TAC1, LTF, SST
19genistein44 28 61 2 24 1113.7CXCL10, SST, IL1A, CD40LG, CCL5, CD4
20endotoxin448.7LTF, CSF3, IL1A, CD40LG, CXCL10, CCL5
21lactate448.5CD40LG, CCL5, CAT, SST, DHFR, VIP
22creatinine448.4LTF, CD79A, MBL2, IL1A, CCL5, CXCL10
23n acetylcysteine448.4CCL11, CCL5, CAT, CD79A, CD40LG, LTF
24fmlp448.3IL1A, CCL11, LTF, CSF3, CCL5, TAC1
25isoproterenol44 119.2VIP, LTF, TAC1, IL1A, IL4, SST
26alanine448.2VIP, LTF, CD40LG, CD79A, CD4, CCL11
27neopterin448.2CD79A, CD40LG, LTF, MBL2, IL4, IL1A
28norepinephrine44 24 1110.1IL1A, LTF, CD40LG, CD79A, TAC1, VIP
29methacholine44 50 1110.1VIP, CCL5, CCL11, IL4, LTF, CD79A
30cyclophosphamide44 50 1110.0MBL2, TAC1, CSF3, IL4, SST, DHFR
31aspartate447.9TAC1, LTF, CD40LG, MBL2, IL1A, VIP
32adenylate447.9CXCL10, DHFR, SST, IL4, TAC1, CD40LG
33cycloheximide447.8CXCL10, CCL5, SST, IL4, IL1A, CSF3
34nitric oxide44 24 119.8VIP, CXCL10, CCL5, CCL11, IL1A, CAT
35heparin44 28 24 1110.8TAC1, CCL5, CCL11, IL1A, CD4, LTF
36actinomycin d447.8LTF, CD40LG, IL4, CCL11, IL1A, CAT
37estrogen447.8LTF, CD79A, CD40LG, CXCL10, DHFR, CCL5
38retinoic acid44 248.8CCL5, CXCL10, DHFR, LTF, SST, CD79A
39cyclosporin a44 28 619.8CD40LG, CD79A, VIP, CCL11, IL1A, CSF3
40epinephrine44 24 119.8IL1A, SST, VIP, TAC1, CD40LG, CD79A
41h2o2447.8DHFR, VIP, CCL5, IL1A, TAC1, CAT
42rantes447.6CD4, MBL2, CSF3, IL1A, IL4, CCL11
43arginine447.6CD79A, TAC1, IL1A, IL4, SST, CD40LG
44glutamate447.3VIP, DHFR, SST, LTF, CD40LG, CD79A
45histamine44 28 249.3TAC1, IL4, CCL11, CCL5, SST, CXCL10
46vegf447.0MBL2, VIP, CD79A, CD40LG, LTF, IL1A
47indomethacin44 28 61 1110.0CCL5, VIP, CCL11, IL4, IL1A, CAT
48cysteine446.7CD40LG, MBL2, CD79A, CD4, LTF, TAC1
49pge2446.5CXCL10, SST, CCL5, CCL11, IL4, IL1A
50dexamethasone44 50 28 119.2MBL2, TAC1, CSF3, IL1A, IL4, CCL11

GO Terms for genes affiliated with Cryptosporidiosis

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Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CD40LG, CD79A, CD4, IL4, CXCL10
2extracellular regionGO:0055767.2VIP, CXCL10, SST, CCL5, CCL11, IL1A
3extracellular spaceGO:0056156.3LTF, CXCL10, SST, CCL5, CCL11, IL4

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0CCL11, CCL5
2regulation of T cell activationGO:05086310.0CD4, CCL5
3leukocyte cell-cell adhesionGO:0071599.9CD40LG, CCL5
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, IL1A
5innate immune response in mucosaGO:0022279.7IL4, LTF
6cellular response to heatGO:0346059.6IL1A, CXCL10
7chemotaxisGO:0069359.5CXCL10, CCL5, CCL11, IL4
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5CCL5, CSF3, CAT
9cell surface receptor signaling pathwayGO:0071669.4CXCL10, SST, CD4
10B cell differentiationGO:0301839.4CD40LG, CD79A, IL4
11cell-cell signalingGO:0072679.0CXCL10, SST, CCL5, TAC1
12negative regulation of apoptotic processGO:0430668.8LTF, CD40LG, CAT, IL4, VIP
13inflammatory responseGO:0069548.6CD40LG, TAC1, IL1A, CCL11, CCL5, CXCL10
14immune responseGO:0069558.5CXCL10, CCL11, IL4, IL1A, CSF3, CD4

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.4CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7CD40LG, CSF3, IL1A, IL4
3protein bindingGO:0055156.9CXCL10, CCL5, CCL11, IL4, IL1A, TAC1

Products for genes affiliated with Cryptosporidiosis

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Sources for Cryptosporidiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet