MCID: CRY003
MIFTS: 46

Cryptosporidiosis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Cryptosporidiosis

Aliases & Descriptions for Cryptosporidiosis:

Name: Cryptosporidiosis 12 50 56 52 41 3 42 14 69
Cryptosporidial Gastroenteritis 12 69
Infection by Cryptosporidium 12
Intestinal Cryptosporidiosis 12

Characteristics:

Orphanet epidemiological data:

56
cryptosporidiosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States),1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1733
ICD10 33 A07.2
ICD9CM 35 007.4
MeSH 42 D003457
Orphanet 56 ORPHA1549
ICD10 via Orphanet 34 A07.2
UMLS via Orphanet 70 C0010418
MESH via Orphanet 43 D003457
UMLS 69 C0010418

Summaries for Cryptosporidiosis

MedlinePlus : 41 cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food, and water. it may also be on surfaces that have been contaminated with feces (poop). you can become infected by swallowing the parasite, if it is in your food, drinking water, or water that you swim in. you can also get it by touching your mouth with contaminated hands. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting contact your health care provider if you have watery diarrhea that lasts more than a few days. most people with crypto get better without treatment within one to two weeks. but crypto can cause serious problems in people with weak immune systems, like those with hiv/aids. to reduce your risk of crypto, wash your hands often, only drink water that you know is safe, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards based summary : Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to immunodeficiency, primary, autosomal recessive, il21r-related and cryptorchidism, and has symptoms including fever and pruritus. An important gene associated with Cryptosporidiosis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and CXCR3-mediated signaling events. The drugs Nitazoxanide and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, small intestine and testes.

NIH Rare Diseases : 50 cryptosporidiosis is an illness caused by the parasite, cryptosporidium. the condition is most commonly associated with watery diarrhea. other signs and symptoms may include dehydration, weight loss, stomach cramps, fever, nausea and/or vomiting. cryptosporidiosis occurs when the parasite enters the body, often through contaminated food and water or because of poor handwashing hygiene. although cryptosporidiosis can affect all people, young children, pregnant women and people with severely weakened immune systems (i.e. those with aids; cancer and transplant patients who are taking certain immunosuppressive drugs; and those with inherited diseases that affect the immune system) are likely to develop a more serious illness. medications such as nitazoxanide have been used to treat diarrhea in both adults and children. however, most people who have healthy immune systems will recover without treatment. last updated: 3/22/2017

CDC : 3 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto.

Disease Ontology : 12 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

Wikipedia : 71 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a genus of... more...

Related Diseases for Cryptosporidiosis

Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
id Related Disease Score Top Affiliating Genes
1 immunodeficiency, primary, autosomal recessive, il21r-related 10.8
2 cryptorchidism 10.8
3 dendritic cell thymoma 10.3 CD79A SST
4 alcoholic neuropathy 10.3 CD40LG CD79A
5 camptodactyly vertebral fusion 10.3 CD40LG CD79A
6 spinal polio 10.3 CD40LG CD79A
7 rabies 10.3 CD40LG CD79A
8 unilateral retinoblastoma 10.3 CD40LG CD79A
9 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
10 delta chain disease 10.3 CD40LG CD79A
11 discitis 10.3 CD40LG CD79A
12 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
13 trichostrongyloidiasis 10.3 CD40LG CD79A
14 colloid adenoma 10.3 CD40LG CD79A
15 heart septal defect 10.3 CD40LG CD79A
16 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
17 mild pre-eclampsia 10.3 CD40LG CD79A
18 retinal microaneurysm 10.3 CD40LG CD79A
19 pediatric meningioma 10.3 CD40LG CD79A
20 tonsil cancer 10.3 CD40LG CD79A
21 indomethacin antenatal infection 10.3 CD40LG CD79A
22 postcricoid region cancer 10.3 CD40LG CD79A
23 beach ear 10.3 CD40LG CD79A
24 malignant renovascular hypertension 10.3 CD79A TAC1
25 acute kidney tubular necrosis 10.3 CD40LG CD79A
26 atheroembolism of kidney 10.3 CD40LG CD79A
27 wells-jankovic syndrome 10.3 SST VIP
28 partial sensory epilepsy 10.3 CD40LG CD79A
29 ritscher-schinzel syndrome 1 10.3 CD40LG CD79A
30 diabetic angiopathy 10.3 CD40LG CD79A
31 endocarditis 10.3 CD40LG CD79A
32 muscular dystrophy 10.3 CD40LG CD79A
33 dumping syndrome 10.3 CD40LG CD79A
34 striatonigral degeneration 10.3 CD40LG CD79A
35 ciliary body spindle cell melanoma 10.3 CD40LG CD79A
36 purulent endophthalmitis 10.3 CD40LG CD79A
37 mu chain disease 10.3 CD40LG CD79A
38 generalized atherosclerosis 10.3 CD40LG CD79A
39 bursitis 10.3 CD40LG CD79A
40 syphilis 10.3 CD40LG CD79A
41 homocystinuria 10.3 CD40LG CD79A
42 mental retardation, autosomal dominant 19 10.3 CD40LG CD79A
43 hemangioma of orbit 10.3 CD40LG CD79A
44 leiomyosarcoma 10.3 CD40LG CD79A
45 immunoglobulin beta deficiency 10.3 CD40LG CD79A
46 gestational diabetes 10.3 CD40LG CD79A
47 choline deficiency disease 10.3 SST VIP
48 odontogenic myxoma 10.3 CD40LG CD79A
49 chronic mucocutaneous candidiasis 10.3 CD40LG CD79A
50 primary thrombocytopenia 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to Cryptosporidiosis

Symptoms & Phenotypes for Cryptosporidiosis

UMLS symptoms related to Cryptosporidiosis:


fever, pruritus

Drugs & Therapeutics for Cryptosporidiosis

Drugs for Cryptosporidiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitazoxanide Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 55981-09-4 41684
2
Azithromycin Approved Phase 3,Phase 1,Phase 2 83905-01-5 55185 53477736 447043
3
Fluconazole Approved Phase 3,Phase 2 86386-73-4 3365
4
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
5
Rifabutin Approved Phase 3 72559-06-9 6323490
6
Sertraline Approved Phase 3 79617-96-2 68617
7 Anti-Infective Agents Phase 3,Phase 2,Phase 1
8 Antiparasitic Agents Phase 3,Phase 2,Phase 1
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Antibiotics, Antitubercular Phase 3
11 Antifungal Agents Phase 3,Phase 2
12 Antitubercular Agents Phase 3
13 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2
14 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Steroid Synthesis Inhibitors Phase 3,Phase 2
19 Antiprotozoal Agents Phase 3,Phase 2,Phase 1
20 Antidepressive Agents Phase 3
21 Neurotransmitter Agents Phase 3
22 Neurotransmitter Uptake Inhibitors Phase 3
23 Psychotropic Drugs Phase 3
24
Serotonin Phase 3 50-67-9 5202
25 Serotonin Agents Phase 3
26 Serotonin Uptake Inhibitors Phase 3
27
Paromomycin Approved, Investigational Phase 2,Phase 1 1263-89-4, 7542-37-2 165580
28
Flucytosine Approved Phase 2 2022-85-7 3366
29 Adjuvants, Immunologic Phase 1, Phase 2
30 Angiogenesis Inhibitors Phase 1, Phase 2
31 Angiogenesis Modulating Agents Phase 1, Phase 2
32 Interleukin-12 Phase 1, Phase 2
33 Antimetabolites Phase 2
34
Loperamide Approved Phase 1 53179-11-6 3955
35
Spiramycin Approved Phase 1 24916-50-5
36 Antibodies Phase 1
37 Antidiarrheals Phase 1
38 Immunoglobulins Phase 1
39 Vaccines Phase 1
40 Whey Protein Nutraceutical Phase 1
41
Formaldehyde Approved, Vet_approved 50-00-0 712
42 Diclazuril
43 gamma-Globulins
44 Immunoglobulins, Intravenous
45 Rho(D) Immune Globulin
46 Disinfectants
47 Ether

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
2 A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium Avium Complex (MAC) and Fungal Infections in HIV-Infected Patients Completed NCT00002122 Phase 3
3 Cryptococcal Antigen Screening Plus Sertraline Not yet recruiting NCT03002012 Phase 3
4 Safety and Effectiveness of Nitazoxanide for the Treatment of Cryptosporidiosis in AIDS Patients Terminated NCT00004986 Phase 3
5 A Double-Blind, Placebo-Controlled Trial of Paromomycin for Treatment of Cryptosporidiosis in Patients With Advanced HIV Disease and CD4 Counts Under 150 Cells/mm3 Completed NCT00000771 Phase 2
6 A Study of Nitazoxanide in Patients With AIDS and Diarrhea Caused by Cryptosporidium Completed NCT00001081 Phase 2
7 Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children Completed NCT00055107 Phase 1, Phase 2
8 Interleukin 12 (IL-12) for the Treatment of Cryptosporidiosis in AIDS Patients Terminated NCT00057486 Phase 1, Phase 2
9 Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection Terminated NCT01562132 Phase 2
10 A Study of Letrazuril in the Treatment of AIDS-Related Diarrhea Completed NCT00001018 Phase 1
11 A Randomized, Multicenter, Double-Blind, Parallel-Group, Placebo-Controlled Trial of the Efficacy and Safety of Bovine Anti-Cryptosporidium Immunoglobulin (BACI) in the Treatment of Cryptosporidium Enteritis in AIDS Patients Completed NCT00002248 Phase 1
12 A Study of Spiramycin in the Treatment of Patients With AIDS-Related Diarrhea Completed NCT00000980 Phase 1
13 A Study of Nitazoxanide in the Treatment of AIDS-Related Diarrhea Completed NCT00002444 Phase 1
14 A Study to Evaluate the Use of Nitazoxanide to Treat Cryptosporidiosis Unknown status NCT00002158
15 Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events Unknown status NCT01699841
16 Transmission and the Respiratory Tract in Cryptosporidiosis Completed NCT00507871
17 Azithromycin in the Treatment of Cryptosporidiosis in Patients Who Have Not Had Success With Other Drugs Completed NCT00002328
18 Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study Completed NCT00002082
19 Protocol For the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433) Completed NCT00002027
20 A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS Completed NCT00002278
21 Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients Completed NCT00002062
22 The Effectiveness of Cow's Milk Immune Globulin in the Treatment of AIDS-Related Diarrhea Completed NCT00002264
23 Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya Completed NCT01695304
24 Field Studies of Amebiasis in Bangladesh Completed NCT02734264
25 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
26 Cryptosporidiosis and Enteropathogens in Bangladesh Recruiting NCT02764918
27 Treatment of Chronic Cryptosporidiosis in AIDS Patients Terminated NCT00001128
28 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Cryptosporidiosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: cryptosporidiosis

Genetic Tests for Cryptosporidiosis

Anatomical Context for Cryptosporidiosis

MalaCards organs/tissues related to Cryptosporidiosis:

39
Lung, Small Intestine, Testes, Liver, Colon, T Cells, Breast

Publications for Cryptosporidiosis

Articles related to Cryptosporidiosis:

(show top 50) (show all 596)
id Title Authors Year
1
Natural History of Cryptosporidiosis in a Birth Cohort in Southern India. ( 28013266 )
2017
2
Waterborne outbreak of cryptosporidiosis in the South East of Ireland: weighing up the evidence. ( 28084584 )
2017
3
Cryptosporidiosis outbreak at an academic animal research laboratory-Colorado, 2014. ( 28079280 )
2017
4
Discovery of new variable number tandem repeat loci in multiple Cryptosporidium parvum genomes for the surveillance and investigation of outbreaks of cryptosporidiosis. ( 27523797 )
2016
5
Protein Malnutrition Impairs Intestinal Epithelial Cell Turnover, a Potential Mechanism of Increased Cryptosporidiosis in a Murine Model. ( 27736783 )
2016
6
The Brief Case: Cryptosporidiosis in a Severely Immunocompromised HIV Patient. ( 27578154 )
2016
7
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis. ( 27923949 )
2016
8
Evolving epidemiology of reported cryptosporidiosis cases in the United States, 1995-2012. ( 27125575 )
2016
9
Acute, Severe Cryptosporidiosis in an Immunocompetent Pediatric Patient. ( 27478580 )
2016
10
Human cryptosporidiosis in Europe. ( 27172805 )
2016
11
Cryptosporidiosis in a buffalo calf at Meerut, Uttar Pradesh and its successful therapeutic management. ( 27876988 )
2016
12
Secondary transmission of cryptosporidiosis associated with well water consumption: two case studies. ( 27192601 )
2016
13
Characterizing the Role of Animal Exposures in Cryptosporidiosis and Shiga Toxin-producing Escherichia coli Infections: South Dakota, 2012. ( 26729474 )
2016
14
Cryptosporidiosis Risk in New Zealand Children Under 5 Years Old is Greatest in Areas with High Dairy Cattle Densities. ( 27766441 )
2016
15
Cryptosporidiosis Drug Discovery: Opportunities and Challenges. ( 27626293 )
2016
16
Immunostaining of Cryptosporidiosis with Human Immunodeficiency Virus Infection. ( 27803428 )
2016
17
Cryptosporidium and cryptosporidiosis: the African perspective. ( 27126869 )
2016
18
Spatial Modelling Tools to Integrate Public Health and Environmental Science, Illustrated with Infectious Cryptosporidiosis. ( 26848669 )
2016
19
Closing the Brief Case: Cryptosporidiosis in a Severely Immunocompromised HIV Patient. ( 27578161 )
2016
20
Assessment of microscopic and molecular tools for the diagnosis and follow-up of cryptosporidiosis in patients at risk. ( 26610340 )
2016
21
Comparison of different diagnostic techniques for the detection of cryptosporidiosis in bovines. ( 27051211 )
2016
22
Contribution of environmental media to cryptosporidiosis and giardiasis prevalence in Tehran: a focus on surface waters. ( 27370533 )
2016
23
Natural History of Cryptosporidiosis in a Longitudinal Study of Slum-Dwelling Bangladeshi Children: Association with Severe Malnutrition. ( 27144404 )
2016
24
Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model. ( 27467505 )
2016
25
Clinical Characteristic of the HIV/AIDS Patients with Cryptosporidiosis Referring to Behavioral Diseases Consultation Center, Imam Khomeini Hospital, Tehran in 2013. ( 26870140 )
2016
26
Pulmonary cryptosporidiosis in an immunocompetent host treated successfully with nitazoxanide. ( 26933311 )
2016
27
A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice. ( 27738055 )
2016
28
A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments. ( 26447884 )
2015
29
Cryptosporidiosis surveillance -- United States, 2011-2012. ( 25928581 )
2015
30
Investigation of a swimming pool-associated cryptosporidiosis outbreak in the Kimberley region of Western Australia. ( 25703474 )
2015
31
Cryptosporidiosis outbreak in a child day-care center caused by an unusual Cryptosporidium hominis subtype. ( 25770777 )
2015
32
A positive association between cryptosporidiosis notifications and ambient temperature, Victoria, Australia, 2001-2009. ( 26608765 )
2015
33
Cryptosporidiosis: a neglected infection and its association with nutritional status in schoolchildren in northwestern Mexico. ( 26322881 )
2015
34
Cryptosporidiosis outbreak in visitors of a UK industry-compliant petting farm caused by a rare Cryptosporidium parvum subtype: a case-control study. ( 26424385 )
2015
35
Comparison of fecal antigen detection using enzyme linked immunosorbent assay with the auramine phenol staining method for diagnosis of human cryptosporidiosis. ( 25825642 )
2015
36
The Risk of Reported Cryptosporidiosis in Children Aged <5 Years in Australia is Highest in Very Remote Regions. ( 26393636 )
2015
37
Initial data on the molecular epidemiology of cryptosporidiosis in Lebanon. ( 25950832 )
2015
38
Notes from the field: cryptosporidiosis associated with consumption of unpasteurized goat milk - Idaho, 2014. ( 25719684 )
2015
39
Notes from the Field: Outbreak of Cryptosporidiosis Among Veterinary Medicine Students--Philadelphia, Pennsylvania, February 2015. ( 26203633 )
2015
40
Evaluation of ImmunoCard STAT test and ELISA versus light microscopy in diagnosis of giardiasis and cryptosporidiosis. ( 25924795 )
2015
41
The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1(+) NK cells and by NCR1(-) CD8(+) cell recruitment. ( 25890354 )
2015
42
Cryptosporidiosis: A Disease of Tropical and Remote Areas in Australia. ( 26393508 )
2015
43
Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis. ( 25945704 )
2015
44
Epidemiological Observations on Cryptosporidiosis in Diarrheic Goat Kids in Greece. ( 26819799 )
2015
45
RENAL AND CLOACAL CRYPTOSPORIDIOSIS (CRYPTOSPORIDIUM AVIAN GENOTYPE V) IN A MAJOR MITCHELL'S COCKATOO (LOPHOCHROA LEADBEATERI). ( 26667555 )
2015
46
Paediatrician and Caregiver Awareness of Cryptosporidiosis and Giardiasis in Children: US Survey Responses. ( 26685056 )
2015
47
Aetiology and epidemiology of human cryptosporidiosis cases in Galicia (NW Spain), 2000-2008. ( 25699561 )
2015
48
Communitywide cryptosporidiosis outbreak associated with a surface water-supplied municipal water system - Baker City, Oregon, 2013. ( 26264893 )
2015
49
Therapeutic effects of acetylspiramycin and garlicin on cryptosporidiosis among drug users. ( 27120065 )
2015
50
An audit of the laboratory diagnosis of cryptosporidiosis in England and Wales. ( 25976007 )
2015

Variations for Cryptosporidiosis

Expression for Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for Cryptosporidiosis

Pathways related to Cryptosporidiosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.34 IL1A SST TAC1
2 10.69 CCL11 CXCL10
3 10.15 CCL11 CD40LG CXCL10 IL1A

GO Terms for Cryptosporidiosis

Cellular components related to Cryptosporidiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CAT CCL11 CD40LG CXCL10 IL1A SST
2 extracellular space GO:0005615 9.17 CAT CCL11 CD40LG CXCL10 IL1A SST

Biological processes related to Cryptosporidiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to radiation GO:0009314 9.26 CAT CCL11
2 immune response GO:0006955 9.26 CCL11 CD40LG CXCL10 IL1A
3 B cell proliferation GO:0042100 9.16 CD40LG CD79A
4 inflammatory response GO:0006954 9.02 CCL11 CD40LG CXCL10 IL1A TAC1

Molecular functions related to Cryptosporidiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.96 CAT DHFR
2 cytokine activity GO:0005125 8.92 CCL11 CD40LG CXCL10 IL1A

Sources for Cryptosporidiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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