MCID: CRY003
MIFTS: 62

Cryptosporidiosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories
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Summaries for Cryptosporidiosis

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Cryptosporidiosis (crypto) is an illness caused by a parasite. the parasite lives in soil, food and water. it may also be on surfaces that have been contaminated with waste. you can become infected if you swallow the parasite. the most common symptom of crypto is watery diarrhea. other symptoms include dehydration weight loss stomach cramps or pain fever nausea vomiting most people with crypto get better with no treatment, but crypto can cause serious problems in people with weak immune systems such as in people with hiv/aids. to reduce your risk of crypto, wash your hands often, avoid water that may be infected, and wash or peel fresh fruits and vegetables before eating. centers for disease control and prevention

MalaCards: Cryptosporidiosis, also known as cryptosporidial gastroenteritis, is related to microsporidiosis and diarrhea. An important gene associated with Cryptosporidiosis is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and IL4-mediated signaling events. The drug nitazoxanide and the compounds pneumococcal and pertussis have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and liver, and related mouse phenotypes are renal/urinary system and normal.

Disease Ontology:8 A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by cryptosporidium species, through contaminated water and food, the symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. immunocompromised persons are at greater risk of developing the infection.

CDC:4 Cryptosporidium is a microscopic parasite that causes the diarrheal disease cryptosporidiosis. Both the parasite and the disease are commonly known as "Crypto."

Wikipedia:65 Cryptosporidiosis, also known as crypto, is a parasitic disease caused by Cryptosporidium, a protozoan... more...

Aliases & Classifications for Cryptosporidiosis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
cryptosporidiosis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

cryptosporidiosis 8 43 10 45 49 34 62
cryptosporidial gastroenteritis 8 62
infection by cryptosporidium 8
intestinal cryptosporidiosis 8


External Ids:

Disease Ontology8 DOID:1733
MeSH35 D003457
ICD9CM27 007.4
MESH via Orphanet36 D003457
ICD10 via Orphanet26 A07.2
SNOMED-CT via Orphanet59 240370009, 58777003
UMLS via Orphanet63 C0010418
ICD1025 A07.2

Related Diseases for Cryptosporidiosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cryptosporidiosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1microsporidiosis30.7CD4
2diarrhea30.6VIP, LTF, CD79A, CD4, TAC1, SST
3gastroenteritis30.3CD79A
4toxoplasmosis30.3CD4, DHFR, CD79A, CD40LG
5pancreatitis30.2LTF, TAC1, SST
6adenocarcinoma30.1TAC1, CXCL10, SST, VIP, CCL5
7acute graft versus host disease30.1CSF3, IL4
8graft versus host disease30.1CSF3, IL4, CCL5
9conjunctivitis30.1CD79A
10hepatitis30.0CCL11, CAT, CD4, CD40LG, CXCL10
11intestinal disease30.0SST
12pneumocystosis30.0DHFR, CD4
13shigellosis30.0CD79A, LTF
14chickenpox30.0CD4, CD79A
15sinusitis29.9CD79A, CCL11, CD4
16candidiasis29.9CD79A, LTF, CD4
17hepatitis c29.8CXCL10, CD40LG, LTF, IL4
18rhinitis29.8IL4, TAC1, CD79A, VIP, CCL5, CCL11
19gastritis29.7SST, CD4, CCL5, CD79A, LTF, CAT
20ulcerative colitis29.7IL1A, IL4, LTF, CD79A, TAC1, VIP
21leukemia29.5CAT, CD40LG, CD79A, CD4, IL4, DHFR
22giardiasis10.5
23acquired immunodeficiency syndrome10.3
24isosporiasis10.3
25hiv/aids10.3
26sclerosing cholangitis10.2
27cholangitis10.2
28cyclosporiasis10.2
29coccidiosis10.2
30folliculitis10.1CCL11
31rheumatic congestive heart failure10.1MBL2
32keratoconjunctivitis10.1CCL11
33keratopathy10.1TAC1
34keratoconjunctivitis sicca10.1LTF
35meningococcemia10.1CCL5
36q fever10.1CD79A
37lactose intolerance10.1LTF
38urethritis10.1CD79A
39cryptococcosis10.1CD4
40histoplasmosis10.1CD4
41poems syndrome10.1CD79A
42bronchiolitis10.1CCL11, CCL5
43listeriosis10.1CD4
44exanthem10.1CD79A
45macroglobulinemia10.1CD79A
46polyarteritis nodosa10.1LTF
47viral meningitis10.1CCL5, CXCL10
48eosinophilic pneumonia10.1CCL5, CCL11
49bronchitis10.1CD79A
50pancreatic cholera10.1SST, VIP

Graphical network of the top 20 diseases related to Cryptosporidiosis:



Diseases related to cryptosporidiosis

Symptoms for Cryptosporidiosis

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Drugs & Therapeutics for Cryptosporidiosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Cryptosporidiosis

Search NIH Clinical Center for Cryptosporidiosis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cryptosporidiosis

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Anatomical Context for Cryptosporidiosis

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33MalaCards
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MalaCards organs/tissues related to Cryptosporidiosis:

33
Lung, Colon, Liver, Testes, T cells, Breast

Animal Models for Cryptosporidiosis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Cryptosporidiosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD40LG, CD79A, MBL2, TAC1, CSF3, IL4
2MP:00028737.3VIP, SST, CCL11, IL4, TAC1, CD4
3MP:00053976.7CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
4MP:00053766.7IL4, SST, CXCL10, VIP, IL1A, CAT
5MP:00053876.3LTF, VIP, CXCL10, SST, CCL5, CCL11

Publications for Cryptosporidiosis

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Sources:
52PubMed
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Articles related to Cryptosporidiosis:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. (22877562)
2013
2
Prevalence of cryptosporidiosis in dairy cattle, cattle-keeping families, their non-cattle-keeping neighbours and HIV-positive individuals in Dagoretti Division, Nairobi, Kenya. (22878888)
2012
3
Cryptosporidiosis-an overview. (22685452)
2012
4
Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature. (22678466)
2012
5
Cryptosporidiosis surveillance--United States, 2009-2010. (22951493)
2012
6
Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. (22247151)
2012
7
Therapy and prevention of cryptosporidiosis in animals. (22521978)
2012
8
A trans-disciplinary study on the health risks of cryptosporidiosis from dairy systems in Dagoretti, Nairobi, Kenya: study background and farming system characteristics. (22886442)
2012
9
Cases of cryptosporidiosis co-infections in AIDS patients: a correlation between clinical presentation and GP60 subgenotype lineages from aged formalin-fixed stool samples. (21929875)
2011
10
Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. (21734132)
2011
11
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
12
Childhood cryptosporidiosis: a case report. (20936160)
2010
13
Cryptosporidiosis in the elderly population of the United States. (19199827)
2009
14
High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. (19954529)
2009
15
A hospital-based serological survey of cryptosporidiosis in the Republic of Korea. (19724694)
2009
16
A Bayesian evaluation of four immunological assays for the diagnosis of clinical cryptosporidiosis in calves. (17493849)
2008
17
Cryptosporidiosis in buffalo calves (Bubalus bubalis): prevalence and potential risk factors. (18575969)
2008
18
Development of fluorescent in situ hybridization for Cryptosporidium detection reveals zoonotic and anthroponotic transmission of sporadic cryptosporidiosis in Sydney. (18789979)
2008
19
Microscopy for cryptosporidiosis screening in remote areas. (18445972)
2008
20
An outbreak of cryptosporidiosis at a day-care centre in Sweden. (17868622)
2007
21
First reported waterborne outbreak of cryptosporidiosis with Cyclospora co-infection in Turkey. (17370959)
2007
22
High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. (17043107)
2007
23
Outbreak of cryptosporidiosis at a California waterpark: employee and patron roles and the long road towards prevention. (17291365)
2007
24
Investigation of potential zooanthroponotic transmission of cryptosporidiosis and giardiasis through agricultural use of reclaimed wastewater. (17164167)
2006
25
Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. (16886154)
2006
26
Effects of weather and river flow on cryptosporidiosis. (16459850)
2005
27
Cryptosporidium and cryptosporidiosis in Denmark--current status. (16252473)
2005
28
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
29
Cryptosporidiosis leading to an unsuspected diagnosis of AIDS. (15460500)
2004
30
Cryptosporidiosis in children in a north Jordanian paediatric hospital. (16335640)
2004
31
Disseminated cryptosporidiosis in Turkey: case report. (15250630)
2003
32
Foot and mouth disease in livestock and reduced cryptosporidiosis in humans, England and Wales. (12533277)
2003
33
Electrophoretic analysis of genetic variability within Cryptosporidium parvum from imported and autochthonous cases of human cryptosporidiosis in the United Kingdom. (12732542)
2003
34
Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosis. (13130414)
2003
35
An outbreak of cryptosporidiosis associated with an animal nursery at a regional fair. (12926737)
2003
36
Prevalence and control of bovine cryptosporidiosis in German dairy herds. (12623207)
2003
37
Cryptosporidiosis. (12686887)
2002
38
Novel cryptosporidium genotypes in sporadic cryptosporidiosis cases: first report of human infections with a cervine genotype. (11927023)
2002
39
PCR-ELISA: a new simplified tool for tracing the source of cryptosporidiosis in HIV-positive patients. (11763435)
2001
40
From the Centers for Disease Control and Prevention. Protracted outbreaks of cryptosporidiosis associated with swimming pool use--Ohio and Nebraska, 2000. (11439938)
2001
41
Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in suckling calves. (11232925)
2001
42
Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis. (11518676)
2001
43
Cryptosporidiosis in Kuwaiti children: seasonality and endemicity. (11422253)
2001
44
Compliance with advice to boil drinking water during an outbreak of cryptosporidiosis. Outbreak Investigation Team. (10902259)
2000
45
Emerging public health concerns regarding cryptosporidiosis. (10976295)
2000
46
Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. (10669358)
2000
47
Role of the enteric nervous system in piglet cryptosporidiosis. (8968331)
1996
48
Coccidiosis and cryptosporidiosis in sheep and goats. (2245367)
1990
49
Mycobacterium marinum infection in a patient with cryptosporidiosis and the acquired immunodeficiency syndrome. (3203532)
1988
50
Cryptosporidiosis and isosporiasis in patients with AIDS. (3060532)
1988

Variations for Cryptosporidiosis

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Expression for genes affiliated with Cryptosporidiosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cryptosporidiosis

Search GEO for disease gene expression data for Cryptosporidiosis.

Pathways for genes affiliated with Cryptosporidiosis

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Sources:
50PathCards, 54R&D Systems, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CCL11, CCL5, CXCL10
29.4CCL11, IL4, CD40LG
39.4IL1A, IL4, CXCL10
49.4CD4, CD79A, CD40LG
5
Show member pathways
9.3CD40LG, IL1A, IL4
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.2CXCL10, CCL11, IL4, IL1A
7
Show member pathways
9.1CXCL10, CCL5, IL4, IL1A
89.0SST, IL1A, TAC1
98.9CD79A, CD4, IL4, CCL5
10
Show member pathways
8.7CCL5, CCL11, IL4, IL1A, CD4
118.7IL4, IL1A, CSF3, CD4
128.7CD4, CSF3, IL1A, IL4
13
Show member pathways
8.7CCL11, IL4, IL1A, CD4, CD40LG
14
Show member pathways
8.6CXCL10, SST, CCL5, CCL11, TAC1
15
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.5IL4, IL1A, CD4, CD79A, CD40LG
16
Show member pathways
8.4CXCL10, SST, CCL5, CCL11, TAC1, VIP
17
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
18
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
19
Show member pathways
8.0CXCL10, CCL5, CCL11, IL4, IL1A, CSF3
20
Show member pathways
7.7CD40LG, CXCL10, CCL5, CCL11, IL4, IL1A

Compounds for genes affiliated with Cryptosporidiosis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB, 51PharmGKB
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Compounds related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 232)
idCompoundScoreTop Affiliating Genes
1pneumococcal459.6CD79A, LTF, DHFR, CD40LG
2pertussis459.5CCL11, VIP, CCL5, LTF, SST
3lactose45 1110.4LTF, CD40LG, DHFR, MBL2, SST
4pmma459.3CD40LG, LTF, CCL5, CD79A
5ccl345 2910.2CXCL10, CCL5, CCL11, CSF3, IL1A
6hemocyanin459.1CD4, CD40LG, CD79A, IL4
7allergens459.1CXCL10, CD40LG, CD79A, IL4, CCL11
8leukotriene b445 61 2411.1LTF, IL1A, CCL11, CCL5, CXCL10
9anti-fungal458.9DHFR, CSF3, MBL2, CD79A, CD40LG, LTF
10tarc458.9CXCL10, CD4, IL1A, IL4, CCL11, CCL5
11chloroquine45 3 51 29 1112.9CD79A, IL4, CXCL10, DHFR, CD4
12hydrocortisone45 3 61 1111.9LTF, SST, CCL5, IL1A, IL4, CXCL10
13thyroxine45 249.9CD79A, VIP, MBL2, SST, CD40LG, IL4
14mannan458.9MBL2, CD79A, CD40LG, CD4
15captopril45 61 51 29 1112.8VIP, SST, TAC1, IL1A, CD79A
16polyethylene glycol458.8VIP, CD79A, IL4, CD40LG, IL1A
17ribavirin45 51 1110.7IL4, CXCL10, LTF, MBL2, CSF3, CD40LG
18propranolol45 29 51 24 1112.7CCL5, VIP, TAC1, LTF, SST
19genistein45 29 61 3 24 1113.7CXCL10, SST, IL1A, CD40LG, CCL5, CD4
20endotoxin458.7LTF, CSF3, IL1A, CD40LG, CXCL10, CCL5
21lactate458.5CD40LG, CCL5, CAT, SST, DHFR, VIP
22creatinine458.4LTF, CD79A, MBL2, IL1A, CCL5, CXCL10
23n acetylcysteine458.4CCL11, CCL5, CAT, CD79A, CD40LG, LTF
24fmlp458.3IL1A, CCL11, LTF, CSF3, CCL5, TAC1
25isoproterenol45 119.2VIP, LTF, TAC1, IL1A, IL4, SST
26alanine458.2VIP, LTF, CD40LG, CD79A, CD4, CCL11
27neopterin458.2CD79A, CD40LG, LTF, MBL2, IL4, IL1A
28norepinephrine45 24 1110.1IL1A, LTF, CD40LG, CD79A, TAC1, VIP
29methacholine45 51 1110.1VIP, CCL5, CCL11, IL4, LTF, CD79A
30cyclophosphamide45 51 1110.0MBL2, TAC1, CSF3, IL4, SST, DHFR
31aspartate457.9TAC1, LTF, CD40LG, MBL2, IL1A, VIP
32adenylate457.9CXCL10, DHFR, SST, IL4, TAC1, CD40LG
33cycloheximide457.8CXCL10, CCL5, SST, IL4, IL1A, CSF3
34nitric oxide45 24 119.8VIP, CXCL10, CCL5, CCL11, IL1A, CAT
35heparin45 29 24 1110.8TAC1, CCL5, CCL11, IL1A, CD4, LTF
36actinomycin d457.8LTF, CD40LG, IL4, CCL11, IL1A, CAT
37estrogen457.8LTF, CD79A, CD40LG, CXCL10, DHFR, CCL5
38retinoic acid45 248.8CCL5, CXCL10, DHFR, LTF, SST, CD79A
39cyclosporin a45 29 619.8CD40LG, CD79A, VIP, CCL11, IL1A, CSF3
40epinephrine45 24 119.8IL1A, SST, VIP, TAC1, CD40LG, CD79A
41h2o2457.8DHFR, VIP, CCL5, IL1A, TAC1, CAT
42rantes457.6CD4, MBL2, CSF3, IL1A, IL4, CCL11
43arginine457.6CD79A, TAC1, IL1A, IL4, SST, CD40LG
44glutamate457.3VIP, DHFR, SST, LTF, CD40LG, CD79A
45histamine45 29 249.3TAC1, IL4, CCL11, CCL5, SST, CXCL10
46vegf457.0MBL2, VIP, CD79A, CD40LG, LTF, IL1A
47indomethacin45 29 61 1110.0CCL5, VIP, CCL11, IL4, IL1A, CAT
48cysteine456.7CD40LG, MBL2, CD79A, CD4, LTF, TAC1
49pge2456.5CXCL10, SST, CCL5, CCL11, IL4, IL1A
50dexamethasone45 51 29 119.2MBL2, TAC1, CSF3, IL1A, IL4, CCL11

GO Terms for genes affiliated with Cryptosporidiosis

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Sources:
16Gene Ontology
See all sources

Cellular components related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CD40LG, CD79A, CD4, IL4, CXCL10
2extracellular regionGO:0055767.2VIP, CXCL10, SST, CCL5, CCL11, IL1A
3extracellular spaceGO:0056156.3LTF, CXCL10, SST, CCL5, CCL11, IL4

Biological processes related to Cryptosporidiosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0CCL11, CCL5
2regulation of T cell activationGO:05086310.0CD4, CCL5
3leukocyte cell-cell adhesionGO:0071599.9CD40LG, CCL5
4positive regulation of interleukin-2 biosynthetic processGO:0450869.7CD4, IL1A
5innate immune response in mucosaGO:0022279.7IL4, LTF
6cellular response to heatGO:0346059.6IL1A, CXCL10
7chemotaxisGO:0069359.5CXCL10, CCL5, CCL11, IL4
8positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5CCL5, CSF3, CAT
9cell surface receptor signaling pathwayGO:0071669.4CXCL10, SST, CD4
10B cell differentiationGO:0301839.4CD40LG, CD79A, IL4
11cell-cell signalingGO:0072679.0CXCL10, SST, CCL5, TAC1
12negative regulation of apoptotic processGO:0430668.8LTF, CD40LG, CAT, IL4, VIP
13inflammatory responseGO:0069548.6CD40LG, TAC1, IL1A, CCL11, CCL5, CXCL10
14immune responseGO:0069558.5CXCL10, CCL11, IL4, IL1A, CSF3, CD4

Molecular functions related to Cryptosporidiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.4CXCL10, CCL5, CCL11
2cytokine activityGO:0051258.7CD40LG, CSF3, IL1A, IL4
3protein bindingGO:0055156.9CXCL10, CCL5, CCL11, IL4, IL1A, TAC1

Products for genes affiliated with Cryptosporidiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cryptosporidiosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet