MCID: CML001
MIFTS: 23

Cumulative Trauma Disorders

Aliases & Classifications for Cumulative Trauma Disorders

MalaCards integrated aliases for Cumulative Trauma Disorders:

Name: Cumulative Trauma Disorders 50 69

External Ids:

UMLS 69 C0035127

Summaries for Cumulative Trauma Disorders

NINDS : 50 Repetitive motion disorders (RMDs) are a family of muscular conditions that result from repeated motions performed in the course of normal work or daily activities. RMDs include carpal tunnel syndrome, bursitis, tendonitis, epicondylitis, ganglion cyst, tenosynovitis, and trigger finger. RMDs are caused by too many uninterrupted repetitions of an activity or motion, unnatural or awkward motions such as twisting the arm or wrist, overexertion, incorrect posture, or muscle fatigue. RMDs occur most commonly in the hands, wrists, elbows, and shoulders, but can also happen in the neck, back, hips, knees, feet, legs, and ankles. The disorders are characterized by pain, tingling, numbness, visible swelling or redness of the affected area, and the loss of flexibility and strength. For some individuals, there may be no visible sign of injury, although they may find it hard to perform easy tasks Over time, RMDs can cause temporary or permanent damage to the soft tissues in the body -- such as the muscles, nerves, tendons, and ligaments - and compression of nerves or tissue. Generally, RMDs affect individuals who perform repetitive tasks such as assembly line work, meatpacking, sewing, playing musical instruments, and computer work. The disorders may also affect individuals who engage in activities such as carpentry, gardening, and tennis.

MalaCards based summary : Cumulative Trauma Disorders is related to overuse syndrome and repetitive motion disorders. The drugs Prednisolone and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and heart.

Related Diseases for Cumulative Trauma Disorders

Diseases related to Cumulative Trauma Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 overuse syndrome 11.6
2 repetitive motion disorders 11.3
3 carpal tunnel syndrome 9.8
4 branchiootic syndrome 1 9.8
5 mononeuropathy of the median nerve, mild 9.8
6 epileptic encephalopathy, childhood-onset 9.8
7 tenosynovitis 9.8

Graphical network of the top 20 diseases related to Cumulative Trauma Disorders:



Diseases related to Cumulative Trauma Disorders

Symptoms & Phenotypes for Cumulative Trauma Disorders

Drugs & Therapeutics for Cumulative Trauma Disorders

Drugs for Cumulative Trauma Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
5
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
6
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
7
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
8
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
9
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
10
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
11
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
12
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
13
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
14
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
15
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
18 tannic acid Approved, Nutraceutical Phase 4
19 Prednisolone acetate Phase 4,Phase 2,Phase 3
20 Analgesics Phase 4,Phase 3,Phase 2
21 glucocorticoids Phase 4,Phase 3,Phase 2
22 Respiratory System Agents Phase 4,Phase 3
23 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
24 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
25 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
27 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
28 Neuroprotective Agents Phase 4,Phase 2,Phase 3
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
30 Tranquilizing Agents Phase 4,Phase 3,Phase 2
31 Analgesics, Non-Narcotic Phase 4,Phase 2
32 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
33 Hormone Antagonists Phase 4,Phase 3,Phase 2
34 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Hormones Phase 4,Phase 3,Phase 2
36 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
40 Anti-Asthmatic Agents Phase 4,Phase 3
41 Anticonvulsants Phase 4,Phase 3
42 Antiemetics Phase 4,Phase 2,Phase 3
43 Antimanic Agents Phase 4,Phase 3
44 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
45 Prednisolone phosphate Phase 4,Phase 2,Phase 3
46 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
47 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Psychotropic Drugs Phase 4,Phase 3,Phase 2
49 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
50 Autonomic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 205)

# Name Status NCT ID Phase Drugs
1 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
2 Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome Completed NCT02652390 Phase 4 Methylprednisolone 80 mg;Methylprednisolone 40 mg
3 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed NCT02313675 Phase 4 Acetaminophen;Ketorolac Tromethamine;Saline
4 Efficacy Study of Local Steroid Injection and Wrist Splinting for Carpal Tunnel Syndrome Completed NCT02140632 Phase 4
5 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
6 Length of Post Operative Dressing After Carpal Tunnel Release Completed NCT01310218 Phase 4
7 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
8 Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters Completed NCT00678314 Phase 4 Ropivacaine 0.2%;Ropivacaine 0.75%;Normal saline
9 Short and Long Term Exposure to Unique, Time-Varying Pulsed Electro-Magnetic Fields in Refractory Carpal Tunnel Syndrome Completed NCT00277563 Phase 4
10 High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy Recruiting NCT02996409 Phase 4 HVIGI;LVIGI
11 Narcotic vs. Non-narcotic Pain Study Protocol Recruiting NCT01974609 Phase 4 Narcotic;non-narcotic
12 Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration Active, not recruiting NCT03196817 Phase 4 betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%
13 Injection Versus Splinting in Carpal Tunnel Syndrome Active, not recruiting NCT02038452 Phase 4 Depo-Medrone
14 Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Enrolling by invitation NCT02029235 Phase 4 Acetaminophen/Hydrocodone;Acetaminophen/Ibuprofen
15 Preoperative Antibiotics for Carpal Tunnel Release Surgery Not yet recruiting NCT03432858 Phase 4 Vancomycin;Cefazolin;Saline Solution
16 Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery Terminated NCT01588158 Phase 4 Acetaminophen;Vicodin
17 Carpal Tunnel Syndrome Release Using PSU Retractor Unknown status NCT01017471 Phase 3
18 Sonographic Examination Cubital Tunnel Release Completed NCT02739945 Phase 3
19 Sonography-guided Steroid Injection for Carpal Tunnel Syndrome Completed NCT02575729 Phase 3 betamethasone
20 Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome Completed NCT02141035 Phase 2, Phase 3 Acetyl-l-carnitine;placebo
21 Preoperative Gabapentine for Carpal Tunnel Completed NCT01632215 Phase 3 Gabapentine
22 Steroid Injection Treatment of Carpal Tunnel Syndrome Completed NCT00806871 Phase 2, Phase 3 Methylprednisolone 40 mg;Methylprednisolone 80 mg;Sodium chloride
23 Gabapentin for Carpal Tunnel Syndrome Completed NCT00137735 Phase 3 Gabapentin
24 Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome Not yet recruiting NCT02870673 Phase 2, Phase 3 SHINCORT;XYLOCAINE
25 NeuroPath Comparative Validation Study Plan Terminated NCT00393549 Phase 3
26 Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome Terminated NCT00266214 Phase 3 lidocaine patch 5%
27 A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures Terminated NCT00209560 Phase 3 fospropofol disodium
28 Minocycline to Reduce Pain After Carpal Tunnel Release Unknown status NCT02051296 Phase 2 Minocycline;placebo
29 Carpal Tunnel Syndrome and Static Magnetic Field Therapy Unknown status NCT00521495 Phase 2
30 Carpal Tunnel Syndrome Treated With 830nm Diode Laser Unknown status NCT00514462 Phase 1, Phase 2
31 Sham Device, Pill Placebo or Treatment For Arm Pain Completed NCT00029497 Phase 2 Amitriptyline
32 Percutaneous Treatment of Carpal Tunnel Syndrome With Scan Completed NCT02514317 Phase 2
33 Fascial Manipulation on the Treatment of Carpal Tunnel Syndrome Completed NCT02495298 Phase 2
34 Alpha Lipoic Acid on Clinical and Electrophysiological Recovery in Carpal Tunnel Syndrome Undergoing Surgical Release Completed NCT02382328 Phase 2 alpha lipoic acid;Placebo
35 BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome Completed NCT02070302 Phase 2 Botulinum Toxin Type A;Placebo
36 Comparison of Effect of Anterior Subcutaneous and Submuscular Transposition on Cubital Tunnel Syndrome Completed NCT01109901 Phase 2
37 Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome Completed NCT01093209 Phase 2
38 Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome Completed NCT00991068 Phase 2 Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch
39 Mechanisms of Neural Mobilization in the Treatment of Chronic Pain Completed NCT00929123 Phase 1, Phase 2
40 The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome Completed NCT00634738 Phase 1, Phase 2
41 Acute Human Study: StimRouter for Peripheral Nerve Stimulation of Discrete Peripheral Nerves Completed NCT00665132 Phase 1, Phase 2
42 The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve Completed NCT00634699 Phase 1, Phase 2
43 Treatment Efficacy of OMT for Carpal Tunnel Syndrome Completed NCT00394043 Phase 2
44 Acupuncture for Carpal Tunnel Syndrome Completed NCT00000394 Phase 2
45 Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome Recruiting NCT02613247 Phase 2
46 Botulinum Toxin for Carpal Tunnel Syndrome Active, not recruiting NCT00701233 Phase 2 Botulinum toxin;Corticosteroid injection into Carpal Tunnel
47 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
48 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
49 Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury Completed NCT01355549 Phase 1
50 Hyaluronic Acid Hydro-dissection Use in Idiopathic Carpal Tunnel Syndrome Guided by Ultrasonic Study Recruiting NCT03180125 Phase 1 Sodium Hyaluronate;Sodium Hyaluronate and 1% lidocain;Corticosteroid and 1%lidocain

Search NIH Clinical Center for Cumulative Trauma Disorders

Genetic Tests for Cumulative Trauma Disorders

Anatomical Context for Cumulative Trauma Disorders

MalaCards organs/tissues related to Cumulative Trauma Disorders:

38
Testes, Skin, Heart, Spinal Cord, Brain

Publications for Cumulative Trauma Disorders

Articles related to Cumulative Trauma Disorders:

(show top 50) (show all 98)
# Title Authors Year
1
Cumulative trauma disorders: A review. ( 28453448 )
2017
2
Hand cumulative trauma disorders in Nigerian custom tailors: the need for redesign of manual scissors. ( 25679401 )
2015
3
Upper limb cumulative trauma disorders for the orthopaedic surgeon. ( 23347753 )
2013
4
Ergonomic basket design to reduce cumulative trauma disorders in tea leaf plucking operation. ( 22316888 )
2012
5
Effective interventions for cumulative trauma disorders of the upper extremity in computer users: practice models based on systematic review. ( 22799052 )
2012
6
Cumulative trauma disorders among California veterinarians. ( 22628088 )
2012
7
Ergonomic risk factors for cumulative trauma disorders in VDU operators. ( 19080046 )
2008
8
Are deficiencies in manual tracking associated with upper extremity cumulative trauma disorders? ( 16865555 )
2007
9
Cumulative trauma disorders in betel pepper leaf-cullers visiting a rehabilitation clinic: experience in Taitung. ( 16013343 )
2005
10
Workplace discrimination and cumulative trauma disorders: the national EEOC ADA research project. ( 16006675 )
2005
11
A high prevalence of cumulative trauma disorders in Iranian instrumentalists. ( 15485578 )
2004
12
Identifying cumulative trauma disorders of the upper extremity in workers' compensation databases. ( 12704623 )
2003
13
Experience of cumulative trauma disorders on life roles of worker and family member: a case study of a married couple. ( 12775930 )
2003
14
Industrial medicine and acute musculoskeletal rehabilitation. 3. Cumulative trauma disorders of the upper limb in computer users. ( 11973690 )
2002
15
Work-related cumulative trauma disorders of the upper extremity: navigating the epidemiologic literature. ( 12210694 )
2002
16
Work-related cumulative trauma disorders and interpreters for the deaf. ( 10808265 )
2000
17
The effectiveness of intervention strategies used to educate clients about prevention of upper extremity cumulative trauma disorders. ( 12441531 )
2000
18
The impact of occupational injury on injured worker and family: outcomes of upper extremity cumulative trauma disorders in Maryland workers. ( 11025491 )
2000
19
Cross-sectional comparison of nerve conduction and vibration threshold testing: do screening tools for occupationally induced cumulative trauma disorders result in differing outcomes? ( 11052212 )
2000
20
Innovative approach for the treatment of cumulative trauma disorders. ( 12441503 )
2000
21
An outcomes study of an occupational medicine intervention program for the reduction of musculoskeletal disorders and cumulative trauma disorders in the workplace. ( 10529939 )
1999
22
The inter-rater reliability and validity of self-report of risk factors for cumulative trauma disorders within the hand therapist population - a pilot study. ( 12441435 )
1999
23
The impact of workplace screening on the occurrence of cumulative trauma disorders and workers' compensation claims. ( 10029952 )
1999
24
Perceived psychological stress and upper extremity cumulative trauma disorders. ( 10205372 )
1999
25
Orthopedic massage: a model for alternative treatment of cumulative trauma disorders. ( 10418348 )
1999
26
Upper-extremity cumulative trauma disorders of workers in aircraft manufacturing. ( 9467115 )
1998
27
Cumulative trauma disorders and repetitive strain injuries. The future. ( 9646754 )
1998
28
Isokinetic peak torque in women with unilateral cumulative trauma disorders and healthy control subjects. ( 9685097 )
1998
29
Cumulative trauma disorders of the upper extremity. ( 9646740 )
1998
30
Preventing upper extremity cumulative trauma disorders. An approach to employee wellness. ( 9748907 )
1998
31
Ergonomic nursing workstation design to prevent cumulative trauma disorders. ( 9329226 )
1997
32
Cumulative trauma disorders in the upper extremities: reliability of the postural and repetitive risk-factors index. ( 9344307 )
1997
33
Repetitive strain injuries and cumulative trauma disorders. ( 9018634 )
1997
34
Ergonomic risk exposure and upper-extremity cumulative trauma disorders in a maquiladora medical devices manufacturing plant. ( 9273881 )
1997
35
Industrial rehabilitation medicine. 3. Case studies in upper extremity cumulative trauma disorders. ( 9084364 )
1997
36
Repetitive strain injuries and cumulative trauma disorders. ( 9018637 )
1997
37
Factors prolonging disability in work-related cumulative trauma disorders. ( 9018609 )
1997
38
Repetitive strain injuries and cumulative trauma disorders. ( 9018632 )
1997
39
Repetitive strain injuries and cumulative trauma disorders. ( 9018633 )
1997
40
Repetitive strain injuries and cumulative trauma disorders. ( 9018631 )
1997
41
Educational techniques used in occupational therapy treatment of cumulative trauma disorders of the elbow, wrist, and hand. ( 9124268 )
1997
42
Reducing risk factors for cumulative trauma disorders (CTDs): the impact of preventive ergonomic training on knowledge, intentions, and practices related to computer use. ( 10165518 )
1997
43
Cumulative trauma disorders: an ergonomic approach for prevention. ( 9470570 )
1997
44
Repetitive strain injuries and cumulative trauma disorders. ( 9018636 )
1997
45
Repetitive strain injuries and cumulative trauma disorders. ( 9018635 )
1997
46
A prospective study for upper-extremity cumulative trauma disorders of workers in aircraft manufacturing. ( 8978519 )
1996
47
Cumulative trauma disorders. ( 8826680 )
1996
48
Repetitive strain injuries and cumulative trauma disorders. ( 8724456 )
1996
49
Recent trends in work-related cumulative trauma disorders of the upper extremities in the United States: an evaluation of possible reasons. ( 8925325 )
1996
50
Cumulative trauma disorders among apparel manufacturing employees in the southeastern United States. ( 8903287 )
1996

Variations for Cumulative Trauma Disorders

Expression for Cumulative Trauma Disorders

Search GEO for disease gene expression data for Cumulative Trauma Disorders.

Pathways for Cumulative Trauma Disorders

GO Terms for Cumulative Trauma Disorders

Sources for Cumulative Trauma Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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