MCID: CSH001
MIFTS: 75

Cushing's Syndrome malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Cancer diseases categories
Download this MalaCard

Summaries for Cushing's Syndrome

About this section


Fully expand this MalaCard
NINDS:43 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards based summary: Cushing's Syndrome, also known as cushing syndrome, is related to acth-secreting pituitary adenoma and adrenal carcinoma, and has symptoms including An important gene associated with Cushing's Syndrome is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Selected targets of CREB1. The drugs fludrocortisone and fluorocortisol acetate and the compounds pitressin and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and testes, and related mouse phenotypes are hematopoietic system and adipose tissue.

Disease Ontology:8 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

NIH Rare Diseases:42 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. symptoms of cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor. last updated: 2/26/2013

MedlinePlus:33 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

Wikipedia:65 Cushing\'s syndrome describes the signs and symptoms associated with prolonged exposure to... more...

Aliases & Classifications for Cushing's Syndrome

About this section

Cushing's Syndrome, Aliases & Descriptions:

Name: Cushing's Syndrome 8 42 43 33
Cushing Syndrome 8 42 22 44 62
Hypercortisolism 42 21 62
Pituitary-Dependant Hypercortisolism Disorder 21 62
Pituitary Basophilism 8 62
Cushings Syndrome 10 62
Adrenal Hyperfunction Resulting from Pituitary Acth Excess 42
Ectopic Adrenocorticotrophic Hormone Syndrome 62
Ectopic Adrenocorticotropic Hormone Syndrome 42
Nodular Primary Adrenocortical Dysplasia 42
Pituitary-Dependent Cushing's Disease 62
Pituitary-Dependant Hypercortisolism 21
 
Pituitary-Dependant Cushing Syndrome 21
Pituitary Acth Hypersecretion 21
Adrenal Gland Hyperfunction 62
Pituitary Cushing Syndrome 21
Adrenal Cortical Adenoma 62
Suprarenogenic Syndrome 8
Adrenal Cortex Adenoma 42
Acth Syndrome, Ectopic 62
Ectopic Acth Syndrome 42
Acth Syndrome Ectopic 44
Hyperadrenocorticism 42
Cushing Disease 21


Classifications:



External Ids:

Disease Ontology8 DOID:12252
ICD9CM27 255.0
NCIt39 C2969
MeSH34 D003480
ICD1025 E24.3

Related Diseases for Cushing's Syndrome

About this section

Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1acth-secreting pituitary adenoma31.0POMC, CRH
2adrenal carcinoma30.9POMC
3zollinger-ellison syndrome30.8CHGA, SST
4pituitary carcinoma30.8POMC
5adrenocortical carcinoma30.7POMC, CYP11B1
6nelson syndrome30.6POMC, SST, CRH
7hypogonadism30.5CRH, POMC, LHCGR
8leydig cell tumor30.5POMC, LHCGR
9hyperandrogenism30.4POMC, CRH, LHCGR
10ganglioneuroma30.4POMC, CHGA
11lung cancer30.4SST, POMC, CHGA
12adrenal gland hyperfunction30.4POMC, GIPR, CRH, SST
13gastrinoma30.4CHGA, SST
14hyperaldosteronism30.4CYP11B1, POMC
15neuroendocrine tumor30.3SST, CHGA, POMC
16hyperprolactinemia30.3POMC, SST, CRH
17neuroendocrine carcinoma30.2CHGA, SST
18conn's syndrome30.1POMC, CYP11B1
19pheochromocytoma30.1POMC, CRH, SST, CHGA
20congenital adrenal hyperplasia30.0CYP11B1, MC2R, POMC, CRH
21hypoglycemia29.8POMC, GIP, CHGA, SST, CRH
22diabetes mellitus29.7GIP, POMC, SST, HSD11B1, GIPR
23adrenal adenoma29.7CYP11B1, HSD11B1, MC2R, POMC, GIPR, CRH
24acromegaly29.7SST, HSD11B1, CRH, GHSR, POMC
25hypertension29.7POMC, CRH, HSD11B1, CYP11B1
26pituitary adenoma29.6POMC, GHSR, CHGA, CRH, SST, MC2R
27obesity29.4GHSR, POMC, MC2R, CRH, HSD11B1, GIP
28adrenal cortical adenoma29.3CYP11B1, MC2R, POMC, GIPR, CRH, CHGA
29adenoma28.0CHGA, SST, GIPR, CRH, GHSR, POMC
30seasonal affective disorder10.5CRH
31small cell carcinoma10.4
32melancholia10.4CRH, POMC
33cushing syndrome due to ectopic acth secretion10.4
34amenorrhea10.4POMC, CRH
35anorexia nervosa10.4POMC, CRH
36sheehan syndrome10.4CRH, POMC
37gonadal disease10.4POMC, CRH
38acth-independent macronodular adrenal hyperplasia10.4
39hypoadrenalism10.4POMC, CRH
40somatostatinoma10.4SST, CHGA
41infantile epileptic encephalopathy10.4POMC, CRH
42endogenous depression10.4CRH, POMC
43bronchial endocrine tumor10.4SST, POMC
44hyperinsulinemic hypoglycemia10.3SST, CHGA
45pancreatic islet cell tumors10.3CHGA, SST
46endocrine gland cancer10.3SST, CHGA
47chronic fatigue syndrome10.3POMC, CRH
48vipoma10.3CHGA, SST
49atrophic gastritis10.3CHGA, SST
50merkel cell carcinoma10.3CHGA, SST

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms for Cushing's Syndrome

About this section

HPO human phenotypes related to Cushing's Syndrome:

(show all 35)
id Description Frequency HPO Source Accession
1 round face hallmark (90%) HP:0000311
2 thin skin hallmark (90%) HP:0000963
3 hypercortisolism hallmark (90%) HP:0001578
4 truncal obesity hallmark (90%) HP:0001956
5 abnormality of adipose tissue hallmark (90%) HP:0009124
6 erectile abnormalities hallmark (90%) HP:0100639
7 decreased fertility typical (50%) HP:0000144
8 nephrolithiasis typical (50%) HP:0000787
9 diabetes mellitus typical (50%) HP:0000819
10 hypertension typical (50%) HP:0000822
11 bruising susceptibility typical (50%) HP:0000978
12 hypertrichosis typical (50%) HP:0000998
13 acne typical (50%) HP:0001061
14 striae distensae typical (50%) HP:0001065
15 muscle weakness typical (50%) HP:0001324
16 recurrent fractures typical (50%) HP:0002757
17 hypokalemia typical (50%) HP:0002900
18 reduced bone mineral density typical (50%) HP:0004349
19 abnormality of immune system physiology typical (50%) HP:0010978
20 cataract occasional (7.5%) HP:0000518
21 secondary amenorrhea occasional (7.5%) HP:0000869
22 hypercortisolism occasional (7.5%) HP:0001578
23 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
24 abdominal pain occasional (7.5%) HP:0002027
25 sleep disturbance occasional (7.5%) HP:0002360
26 hypercalcemia occasional (7.5%) HP:0003072
27 abnormality of lipid metabolism occasional (7.5%) HP:0003119
28 myopathy occasional (7.5%) HP:0003198
29 hypernatremia occasional (7.5%) HP:0003228
30 abnormality of the gastric mucosa occasional (7.5%) HP:0004295
31 reduced consciousness/confusion occasional (7.5%) HP:0004372
32 aseptic necrosis occasional (7.5%) HP:0010885
33 abnormal renal physiology occasional (7.5%) HP:0012211
34 teleangiectasia of the skin occasional (7.5%) HP:0100585
35 neoplasm of the adrenal gland occasional (7.5%) HP:0100631

Drugs & Therapeutics for Cushing's Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cushing's Syndrome

About this section

Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

About this section

MalaCards organs/tissues related to Cushing's Syndrome:

32
Pituitary, Adrenal gland, Testes, Cortex, Adrenal cortex, Bone, Kidney, Skin, Thyroid, Lung, Heart, Liver, Ovary, Prostate, Thymus, Pancreas, Pancreatic islet, Eye, Brain, Skeletal muscle, Colon, Adipocyte, Testis, Cervix, Endothelial, Hypothalamus

Animal Models for Cushing's Syndrome or affiliated genes

About this section

Publications for Cushing's Syndrome

About this section

Articles related to Cushing's Syndrome:

(show top 50)    (show all 902)
idTitleAuthorsYear
1
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. (24571724)
2014
2
Metachronous bilateral adrenocortical functional adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome. (25197412)
2014
3
Screening for Cushing's syndrome: new immunoassays require adequate normative data. (23417245)
2013
4
Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome. (24083069)
2013
5
Hypercoagulable state in Cushing's syndrome is reversible following remission. (22724622)
2013
6
Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy. (22767639)
2012
7
Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. (22190002)
2012
8
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
9
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
10
Effect of Cushing's syndrome - Endogenous hypercortisolemia on cardiovascular autonomic functions. (21177144)
2011
11
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
12
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
13
Bone turnover in patients with endogenous Cushing's syndrome before and after successful treatment. (19513576)
2010
14
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
15
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
16
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. (20829630)
2010
17
Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone]. (19419710)
2009
18
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
19
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. (18827959)
2008
20
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17223996)
2007
21
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
22
Cushing's syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? (18183788)
2007
23
Role for laparoscopic adrenalectomy in patients with Cushing's syndrome. (18209873)
2007
24
Pharmacological management of Cushing's syndrome: an update. (18209872)
2007
25
Cushing's Syndrome: important issues in diagnosis and management. (16868050)
2006
26
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
27
18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome. (15817906)
2005
28
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
29
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome. (14606715)
2003
30
Meningioma presenting with Cushing's syndrome: an unusual clinical presentation. (12509860)
2003
31
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia. (12744099)
2003
32
Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome? (14669823)
2003
33
A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of Cushing's syndrome: a comparison with the standard high-dose dexamethasone suppression test. (12523812)
2002
34
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
35
Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. (11701732)
2001
36
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
37
Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH. (11248744)
2001
38
The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies. (11004721)
2000
39
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
40
Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. (9013748)
1996
41
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
42
A case of splenic artery aneurysm with Cushing's syndrome. (8818750)
1996
43
Psychiatric aspects of Cushing's syndrome. (8759496)
1996
44
Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: pituitary-adrenocortical function and immunohistochemistry. (8774967)
1995
45
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
46
Cushing's syndrome associated with lung tumors. (1313485)
1992
47
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
48
Primary bilateral adrenocortical causes of Cushing's syndrome. (1745978)
1991
49
The corticotropin-releasing factor test in the differential diagnosis of Cushing's syndrome: a comparison with the lysine-vasopressin test. (2239082)
1990
50
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970

Variations for Cushing's Syndrome

About this section

Expression for genes affiliated with Cushing's Syndrome

About this section
Expression patterns in normal tissues for genes affiliated with Cushing's Syndrome

Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

About this section

Pathways related to Cushing's Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9POMC, CRH
29.3CRH, CHGA, MC2R
3
Show member pathways
9.2POMC, GIPR, GIP, CRH
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.1HSD11B1, CYP11B1
59.0CRH, POMC, CYP11B1
6
Show member pathways
8.8POMC, HSD11B1, CYP11B1
7
Show member pathways
Peptide GPCRs37
8.5AVPR1B, LHCGR, MC2R, GHSR
88.1LHCGR, MC2R, POMC, GIPR, GIP, CRH
9
Show member pathways
6.8AVPR1B, LHCGR, MC2R, POMC, GIPR, GIP
10
Show member pathways
6.8CRH, AVPR1B, LHCGR, MC2R, POMC, GIPR

Compounds for genes affiliated with Cushing's Syndrome

About this section

Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1pitressin449.9SST, POMC, CRH
25-hydroxytryptophan449.8CHGA, SST, CRH
35-hydroxyindoleacetic acid44 2410.8CRH, CHGA, SST
4hcrh449.8GHSR, CRH, POMC
5desmopressin44 61 28 1112.7CRH, POMC, AVPR1B
6ghrp-628 4410.7GHSR, SST
7acth 1-24449.6MC2R, POMC, CRH
8lanreotide44 2810.6CHGA, SST, GHSR
9naloxone44 28 50 1112.6CRH, SST, POMC
105-hydroxytryptamine449.5CHGA, SST, POMC, CRH
11clonidine44 50 28 1112.4SST, CHGA, POMC
1211 deoxycortisol449.4CYP11B1, CRH, POMC
13hexarelin44 2810.4CRH, GHSR, SST, POMC
14gaba449.3POMC, CRH, SST, CHGA
1517-hydroxyprogesterone44 2410.3CRH, POMC, CYP11B1
16dehydroepiandrosterone sulfate449.3CRH, MC2R, POMC
17spironolactone44 61 28 50 1113.3CRH, POMC, CYP11B1
18isoproterenol44 1110.3CHGA, LHCGR, CRH, SST
19cortisol28 2410.2POMC, CYP11B1, HSD11B1
20epinephrine44 24 1111.2SST, CHGA, POMC, CRH, GIP
21gnrh449.1LHCGR, CRH, SST, CHGA, POMC
22dhea449.1MC2R, POMC, CRH, HSD11B1
23octreotide44 61 28 1112.1POMC, CHGA, SST, GHSR, CRH
24ketoconazole44 28 24 1112.0CRH, SST, CYP11B1, POMC
25dopamine44 28 24 1112.0GHSR, SST, CHGA, POMC, CRH
26cortisone44 249.9POMC, CYP11B1, HSD11B1, CRH
2711b-Hydroxyandrost-4-ene-3,17-dione248.8HSD11B1, CYP11B1
28pge2448.8POMC, CRH, HSD11B1, LHCGR, SST
29histidine448.6GIP, LHCGR, CHGA, CYP11B1
30estrogen448.4CHGA, GHSR, CRH, POMC, HSD11B1, LHCGR
3111beta-hydroxysteroid448.3POMC, CYP11B1, HSD11B1, CRH, MC2R
32glucose448.3GHSR, HSD11B1, POMC, GIP, CHGA, SST
33androstenedione44 249.3CRH, POMC, MC2R, HSD11B1, CYP11B1
343beta-hydroxysteroid448.2LHCGR, MC2R, POMC, CYP11B1, HSD11B1
35corticosterone44 61 2410.2AVPR1B, CRH, POMC, HSD11B1, LHCGR, CYP11B1
36progesterone44 28 61 24 1112.2CYP11B1, POMC, HSD11B1, LHCGR, CRH, CHGA
37cyclic amp44 249.0LHCGR, CRH, GIP, MC2R, CYP11B1, CHGA
38estradiol44 24 119.9HSD11B1, CYP11B1, POMC, LHCGR, CRH, GHSR
39metyrapone44 61 119.9CRH, MC2R, POMC, SST, CYP11B1, HSD11B1
40cholesterol44 28 24 1110.8CHGA, MC2R, CYP11B1, LHCGR, HSD11B1
41adenylate447.7SST, GIP, MC2R, POMC, CRH, GHSR
42alanine447.5HSD11B1, LHCGR, CYP11B1, MC2R, CRH, GIP
43hydrocortisone44 2 61 1110.4MC2R, CYP11B1, HSD11B1, POMC, SST, GHSR
44dexamethasone44 50 28 1110.1SST, CHGA, CRH, POMC, HSD11B1, CYP11B1
45arginine447.1AVPR1B, LHCGR, POMC, GIP, CHGA, SST
46steroid447.1CRH, GHSR, MC2R, CHGA, LHCGR, POMC
47ribonucleic acid446.8MC2R, GIPR, CHGA, GHSR, CRH, POMC
48forskolin44 50 118.7LHCGR, MC2R, POMC, GIP, CYP11B1, HSD11B1
49testosterone44 61 24 119.7GHSR, SST, CHGA, MC2R, HSD11B1, CRH
50acth446.1SST, CYP11B1, LHCGR, GHSR, MC2R, POMC

GO Terms for genes affiliated with Cushing's Syndrome

About this section

Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5GIP, POMC
2extracellular regionGO:0055768.8CRH, SST, CHGA, GIP, POMC

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to axon injuryGO:04867810.0GIP, GIPR
2long-term synaptic potentiationGO:06029110.0GIP, CRH
3hormone-mediated apoptotic signaling pathwayGO:00862810.0CRH, SST
4positive regulation of insulin secretionGO:0320249.9GIPR, GIP
5positive regulation of cAMP-mediated signalingGO:0439509.9GIP, LHCGR
6activation of adenylate cyclase activityGO:0071909.9GIPR, LHCGR
7response to amino acidGO:0432009.9GIP, SST
8endocrine pancreas developmentGO:0310189.9GIP, GIPR
9positive regulation of cAMP biosynthetic processGO:0308199.7CRH, MC2R
10generation of precursor metabolites and energyGO:0060919.6GIPR, POMC
11G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.4LHCGR, MC2R
12regulation of blood pressureGO:0082179.4CYP11B1, POMC, CHGA
13response to drugGO:0424939.3CRH, SST, GIP
14steroid metabolic processGO:0082029.1HSD11B1, CYP11B1
15glucocorticoid biosynthetic processGO:0067049.1CRH, HSD11B1, CYP11B1
16G-protein coupled receptor signaling pathwayGO:0071868.4GHSR, SST, MC2R, LHCGR, AVPR1B

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:0170469.7GHSR, GIPR
2hormone activityGO:0051798.8CRH, SST, GIP, POMC

Products for genes affiliated with Cushing's Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Cushing's Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet