MCID: CSH001
MIFTS: 64

Cushing's Syndrome malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Cushing's Syndrome

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Aliases & Descriptions for Cushing's Syndrome:

Name: Cushing's Syndrome 11 48 49 38 13
Cushing Syndrome 11 48 50 39 68
Cushing's Disease 27 13
Adrenal Hyperfunction Resulting from Pituitary Acth Excess 48
Ectopic Adrenocorticotropic Hormone Syndrome 48
Nodular Primary Adrenocortical Dysplasia 48
Adrenal Gland Hyperfunction 68
Adrenal Cushing's Syndrome 68
Adrenal Cortical Adenoma 68
 
Suprarenogenic Syndrome 11
Acth Syndrome, Ectopic 68
Adrenal Cortex Adenoma 48
Acth Syndrome Ectopic 50
Ectopic Acth Syndrome 48
Pituitary Basophilism 11
Hyperadrenocorticism 48
Hypercortisolism 48

Classifications:



External Ids:

Disease Ontology11 DOID:12252
ICD1030 E24, E24.9, E24.3
ICD9CM32 255.0
MeSH39 D003480
NCIt45 C2969

Summaries for Cushing's Syndrome

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MedlinePlus:38 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Cushing's Syndrome, also known as cushing syndrome, is related to adrenal carcinoma and obesity, and has symptoms including round face, thin skin and hypercortisolism. An important gene associated with Cushing's Syndrome is GNAS (GNAS Complex Locus), and among its related pathways are Serotonin Receptor 4/6/7 and NR3C Signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs mitotane and aminoglutethimide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and testes, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and no phenotypic analysis.

Disease Ontology:11 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

NIH Rare Diseases:48 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). It most commonly affects adults between age 20 and 50 years. Signs and symptoms of Cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. Affected women may also experience irregular menstrual periods and increased growth of body and facial hair. This condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors. Last updated: 11/28/2014

NINDS:49 Cushing's syndrome, also called

Wikipedia:71 Cushing\'s syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol. Signs... more...

Related Diseases for Cushing's Syndrome

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Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Macronodular Adrenal Hyperplasia
Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal carcinoma29.1CRH, HSD11B1, POMC, SST
2obesity27.9GNAS, HSD11B1, MC2R, NR3C1, PDE8B, POMC
3cushing syndrome due to ectopic acth secretion12.1
4cushing syndrome due to macronodular adrenal hyperplasia11.9
5pituitary adenoma, acth-secreting11.8
6cushing syndrome, familial11.7
7acth-independent macronodular adrenal hyperplasia11.6
8pigmented nodular adrenocortical disease, primary, 411.6
9pigmented nodular adrenocortical disease, primary, 311.5
10pigmented nodular adrenocortical disease, primary, 111.5
11pigmented nodular adrenocortical disease, primary, 211.4
12acth-independent macronodular adrenal hyperplasia 211.4
13glucocorticoid resistance10.9
14mccune-albright syndrome, somatic, mosaic10.9
15adrenal gland hyperfunction10.7
16hyper-igm syndrome without susceptibility to opportunistic infections10.6ARMC5, GNAS
17primary pigmented nodular adrenocortical disease10.5
18pseudohypoparathyroidism, type ib10.5GNAS, PRKAR1A
19nelson syndrome10.5
20acute cervicitis10.5CRH, NR3C1
21brain angioma10.4POMC, SST
22hypocomplementemic urticarial vasculitis syndrome10.4CRH, POMC
23mobitz type ii atrioventricular block10.4POMC, SST
24osseous heteroplasia, progressive10.4GNAS, POMC, PRKAR1A
25acute myeloid leukemia, kit-related10.4CRH, POMC
26lipid-rich carcinoma10.4POMC, SST
27dressler's syndrome10.3CRH, POMC
28fibroma10.3GNAS, SST
29adrenal medulla cancer10.3GNAS, PRKAR1A, SST
30hypoglycemic coma10.3CRH, NR3C1, POMC
31multiple mitochondrial dysfunctions syndrome10.3CRH, POMC
32gallbladder adenoma10.3GIPR, POMC
33pyoderma gangrenosum10.3CRH, NR3C1, POMC
34immunodeficiency, common variable, 510.3GNAS, PRKAR1A, SST
35purpura10.3CRH, NR3C1, POMC
36ataxia, spastic, 5, autosomal recessive10.2MC2R, POMC
37autoimmune disease of central nervous system10.2CRH, POMC
38male reproductive organ benign neoplasm10.2GNAS, POMC, SST
39alveoli adenoma10.2GNAS, POMC, SST
4010.2CRH, POMC, SST
41cardiovascular organ benign neoplasm10.2CRH, POMC, SST
42vestibular gland benign neoplasm10.2CRH, POMC, SST
43benign shuddering attacks10.2HSD11B2, POMC
44neurilemmoma of the pleura10.1CRH, GIPR, POMC
45hypoaldosteronism, congenital, due to cmo ii deficiency10.1HSD11B2, NR3C1, POMC
46fumarate hydratase deficiency10.1GH1, GNAS
47corpus luteum cyst10.1CRH, HSD11B2, POMC
48congenital epulis10.1CRH, POMC
49autoimmune oophoritis10.0GH1, POMC
50pituitary-dependent cushing's disease10.0

Comorbidity relations with Cushing's Syndrome via Phenotypic Disease Network (PDN):


Acute CystitisAdrenal Cortical Hypofunction
Anxiety DisorderBronchitis
Chronic Pulmonary Heart DiseaseDeficiency Anemia
EsophagitisHeart Disease
Hypertension, EssentialOsteoporosis
Postinflammatory Pulmonary FibrosisRespiratory Failure
Rheumatoid ArthritisStatus Asthmaticus
Temporal ArteritisHypothyroidism
Oral Candidiasis

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms & Phenotypes for Cushing's Syndrome

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Human phenotypes related to Cushing's Syndrome:

 64 (show all 33)
id Description HPO Frequency HPO Source Accession
1 round face64 hallmark (90%) HP:0000311
2 thin skin64 hallmark (90%) HP:0000963
3 hypercortisolism64 hallmark (90%) HP:0001578
4 truncal obesity64 hallmark (90%) HP:0001956
5 abnormality of adipose tissue64 hallmark (90%) HP:0009124
6 erectile abnormalities64 hallmark (90%) HP:0100639
7 decreased fertility64 typical (50%) HP:0000144
8 nephrolithiasis64 typical (50%) HP:0000787
9 diabetes mellitus64 typical (50%) HP:0000819
10 hypertension64 typical (50%) HP:0000822
11 bruising susceptibility64 typical (50%) HP:0000978
12 hypertrichosis64 typical (50%) HP:0000998
13 acne64 typical (50%) HP:0001061
14 striae distensae64 typical (50%) HP:0001065
15 muscle weakness64 typical (50%) HP:0001324
16 recurrent fractures64 typical (50%) HP:0002757
17 hypokalemia64 typical (50%) HP:0002900
18 reduced bone mineral density64 typical (50%) HP:0004349
19 cataract64 occasional (7.5%) HP:0000518
20 secondary amenorrhea64 occasional (7.5%) HP:0000869
21 hypertrophic cardiomyopathy64 occasional (7.5%) HP:0001639
22 abdominal pain64 occasional (7.5%) HP:0002027
23 sleep disturbance64 occasional (7.5%) HP:0002360
24 hypercalcemia64 occasional (7.5%) HP:0003072
25 abnormality of lipid metabolism64 occasional (7.5%) HP:0003119
26 myopathy64 occasional (7.5%) HP:0003198
27 hypernatremia64 occasional (7.5%) HP:0003228
28 abnormality of the gastric mucosa64 occasional (7.5%) HP:0004295
29 reduced consciousness/confusion64 occasional (7.5%) HP:0004372
30 aseptic necrosis64 occasional (7.5%) HP:0010885
31 abnormal renal physiology64 occasional (7.5%) HP:0012211
32 telangiectasia of the skin64 occasional (7.5%) HP:0100585
33 neoplasm of the adrenal gland64 occasional (7.5%) HP:0100631

UMLS symptoms related to Cushing's Syndrome:


cushingoid facies, agitation

GenomeRNAi Phenotypes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.3GH1, HSD11B2, POMC

MGI Mouse Phenotypes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.2CRH, GNAS, HSD11B2, NR3C1, POMC, SST
2MP:00053678.5CRH, GNAS, HSD11B2, NR3C1, PDE8B, POMC
3MP:00053757.6CRH, GNAS, HSD11B1, MC2R, NR3C1, POMC
4MP:00053857.6GNAS, HSD11B1, HSD11B2, MC2R, NR3C1, POMC
5MP:00053797.4CRH, GIPR, GNAS, HSD11B1, MC2R, NR3C1
6MP:00036317.4CRH, GNAS, HSD11B1, MC2R, NR3C1, PDE11A
7MP:00053867.3CRH, GNAS, HSD11B1, HSD11B2, MC2R, NR3C1
8MP:00053766.0CRH, GIPR, GNAS, HSD11B1, HSD11B2, MC2R

Drugs & Therapeutics for Cushing's Syndrome

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Drugs for Cushing's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 83)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved, vet_approvedPhase 4, Phase 3, Phase 293351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2
Mifepristoneapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 114884371-65-355245
Synonyms:
(11beta,17beta)-11-(4-(Dimethylamino)-phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
(11beta,17beta)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-prop-1-yn-1-ylestra-4,9-dien-3-one
(2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
(8S,11R,13S,14S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
11-(4-DIMETHYLAMINO-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodec ahydro-cyclopenta[a]phenanthren-3-one
11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on
11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on
11beta-(4-(N,N-Dimethylamino)phenyl)-17alpha-(prop-1-ynyl)-delta4,9-estradiene-17beta-ol-3-one
11beta-(4-Dimethyl-?amino)-?phenyl-17beta-hydroxy-17-(1-propynyl)-?estra-4,9-dien-3-one
11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
122742-25-0
17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one
404951-53-7
83203-42-3
84371-65-3
AC1L1IOO
AC1O62SB
Ambap84371-65-3
BIDD:PXR0123
BPBio1_000262
BRD-K37270826-001-04-5
BRN 5779404
BSPBio_000238
C-1073
C07652
C29H35NO2
CHEBI:50692
CHEMBL157
CHEMBL356066
CI-1073
CID55245
CID6445533
CPD000058481
Contragest Brand of Mifepristone
Corlux
D00585
D015735
DB00834
Dacinostat
Danco Brand of Mifepristone
EC-000.2469
EU-0100801
Exelgyn Brand of Mifepristone
FT-0082666
HMS1568L20
HMS2052L05
HMS2090L22
HSCI1_000369
HSDB 6841
I14-11726
LAQ-824
LS-192513
LS-64723
Lopac0_000801
M 8046
 
M8046_SIGMA
MLS000069785
MLS001074115
Mifegyne
Mifeprex
Mifeprex (TN)
Mifepriston
Mifepristona
Mifepristona [Spanish]
Mifepristone (USAN/INN)
Mifepristone Contragest Brand
Mifepristone Danco Brand
Mifepristone Exelgyn Brand
Mifepristone [USAN:INN:BAN]
Mifepristonum
Mifepristonum [Latin]
Mifépristone
MolPort-003-849-222
NCGC00025179-05
NCGC00025179-08
NCGC00179632-01
NVP-LAQ 824
NVP-LAQ824
NVP-LAQ824, Dacinostat, LAQ824
Pictovir
Pictovir (TM)
Prestwick0_000299
Prestwick1_000299
Prestwick2_000299
Prestwick3_000299
Prestwick_570
R 38486
R-38486
R38486
RU 38486
RU 486
RU 486-6
RU-38486
RU-486
RU-486, MIFEPRISTONE
RU-486, RU-38486, Mifegyne, Mifeprex, Mifepristone
RU38486
RU486
S1095_Selleck
S1611_Selleck
SAM001246881
SMR000058481
SPBio_002457
Spectrum5_002045
TL8005515
UNII-320T6RNW1F
UNII-V10P524501
VGX-410
VGX-410C
VX-410
ZINC03831128
ZK 98296
ZK-98296
ZK98296
mifepristone
nchembio.313-comp12
3
SomatostatinapprovedPhase 4, Phase 222938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 112767
5RacepinephrinePhase 4, Phase 3, Phase 2933
6HormonesPhase 4, Phase 2, Phase 3, Phase 113979
7Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 112778
8glucocorticoidsPhase 4, Phase 2, Phase 3, Phase 14920
9Epinephryl boratePhase 4, Phase 3, Phase 2933
10Contraceptives, OralPhase 4, Phase 3, Phase 2, Phase 11292
11Luteolytic AgentsPhase 4, Phase 3, Phase 2, Phase 1294
12Contraceptives, PostcoitalPhase 4, Phase 3, Phase 2, Phase 1169
13Contraceptive AgentsPhase 4, Phase 3, Phase 2, Phase 11901
14
LactitolPhase 4332585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
15
MetforminapprovedPhase 2, Phase 31746657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
16
Hydrocortisoneapproved, vet_approvedPhase 3, Phase 2, Phase 164050-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
17
Dexamethasoneapproved, investigational, vet_approvedPhase 3208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
18
Lidocaineapproved, vet_approvedPhase 2, Phase 31226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
19
MetyraponeapprovedPhase 31254-36-44174
Synonyms:
1,2-Di-3-pyridyl-2-methyl-1-propanone
2-Methyl-1,2-bis(3-pyridyl)-1-propanone
2-Methyl-1,2-di-3-pyridinyl-1-propanone
2-Methyl-1,2-di-3-pyridyl-1-propanone
2-methyl-1,2-dipyridin-3-yl-propan-1-one
2-methyl-1,2-dipyridin-3-ylpropan-1-one
37245-80-0
4885, SU
54-36-4
856525_ALDRICH
AB00513955
AC1L1HKV
AC1Q1LHX
Alliance Brand of Metyrapone
BIDD:PXR0082
BPBio1_000824
BRD-K46862739-001-03-6
BSPBio_000748
C07205
C14H14N2O
CAS-54-36-4
CHEBI:44241
CHEMBL934
CID4174
CPD-7023
CPD000059134
D00410
D008797
DB01011
EINECS 200-206-2
EU-0009322
HMS1570F10
HMS2094I07
HSDB 2500
LS-123097
METOPIRONE (TN)
MLS001066377
MLS001335881
MLS001335882
MYT
 
Mepyrapone
Metapirone
Metapyron
Methapyrapone
Methbipyranone
Methopirapone
Methopyrapone
Methopyrinine
Methopyrone
Metirapona
Metirapona [INN-Spanish]
Metopiron
Metopirone
Metopyrone
Metroprione
Metyrapon
Metyrapone
Metyrapone (JP15/USP/INN)
Metyrapone Alliance Brand
Metyrapone Novartis Brand
Metyrapone [USAN:INN:BAN:JAN]
Metyraponum
Metyraponum [INN-Latin]
MolPort-001-794-644
NCGC00016242-01
NCGC00161837-01
NSC 25265
NSC25265
Novartis Brand of Metyrapone
Prestwick0_000904
Prestwick1_000904
Prestwick2_000904
Prestwick3_000904
SAM002297829
SMR000059134
SPBio_002947
ST51006925
Su 4885
Su-4885
UNII-ZS9KD92H6V
ZINC00001728
metyrapone
20AnestheticsPhase 2, Phase 39001
21Hypoglycemic AgentsPhase 2, Phase 35733
22Adrenergic beta-AgonistsPhase 2, Phase 31640
23Adrenergic AgonistsPhase 2, Phase 32877
24Adrenergic AgentsPhase 2, Phase 35140
25AndrogensPhase 2, Phase 31275
26Anti-Asthmatic AgentsPhase 2, Phase 33369
27Respiratory System AgentsPhase 2, Phase 34818
28Vasoconstrictor AgentsPhase 2, Phase 32027
29Neurotransmitter AgentsPhase 2, Phase 317734
30MydriaticsPhase 2, Phase 3763
31Bronchodilator AgentsPhase 2, Phase 32856
32Peripheral Nervous System AgentsPhase 3, Phase 222776
33Adrenergic alpha-AgonistsPhase 2, Phase 31625
34Adrenocorticotropic HormonePhase 3, Phase 2155
35Autonomic AgentsPhase 3, Phase 29774
36beta-endorphinPhase 3, Phase 2133
37Anti-Inflammatory AgentsPhase 310355
38Antirheumatic AgentsPhase 310627
39Melanocyte-Stimulating HormonesPhase 3, Phase 2132
40Cortisol succinatePhase 3, Phase 2, Phase 1640
41Hydrocortisone 17-butyrate 21-propionatePhase 3, Phase 2, Phase 1640
42Hydrocortisone acetatePhase 3, Phase 2, Phase 1640
43Interleukin 1 Receptor Antagonist ProteinPhase 396
44Antineoplastic Agents, HormonalPhase 3, Phase 25407
45Dexamethasone acetatePhase 320841177-87-3
46HIV Protease InhibitorsPhase 35319
47
protease inhibitorsPhase 35320
Synonyms:
 
protease inhibitors
48Gastrointestinal AgentsPhase 3, Phase 28109
49BB 1101Phase 32084
50Dexamethasone 21-phosphatePhase 32084

Interventional clinical trials:

(show top 50)    (show all 70)
idNameStatusNCT IDPhase
1Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal HypercortisolismCompletedNCT01990560Phase 4
2Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyCompletedNCT01959711Phase 4
3Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study.RecruitingNCT01794793Phase 4
4Prevention of Metabolic Complications of Glucocorticoid ExcessUnknown statusNCT01319994Phase 2, Phase 3
5Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's SyndromeCompletedNCT01371565Phase 3
6An Extension Study of CORLUX in the Treatment of Endogenous Cushing's SyndromeCompletedNCT00936741Phase 3
7A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's SyndromeCompletedNCT00569582Phase 3
8Effects of IL-1 Beta on the HPA-axis in Obese PersonsCompletedNCT02227420Phase 3
9Treatment for Endogenous Cushing's SyndromeRecruitingNCT01838551Phase 3
10Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?RecruitingNCT01504555Phase 3
11Effects of Metyrapone in Patients With Endogenous Cushing's SyndromeNot yet recruitingNCT02297945Phase 3
12Dynamic Hormone Diagnostics in Endocrine DiseaseNot yet recruitingNCT02934399Phase 2, Phase 3
13Mifepristone in Children With Refractory Cushing's DiseaseWithdrawnNCT01925092Phase 3
14A Study to Assess SOM230 in Patients With Pituitary Cushing's DiseaseCompletedNCT00088608Phase 2
15SOM230 Ectopic ACTH-producing TumorsRecruitingNCT02780882Phase 2
16Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing SyndromeRecruitingNCT02019706Phase 2
17Study of Efficacy and Safety of Osilodrostat in Cushing's SyndromeRecruitingNCT02468193Phase 2
18New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing SyndromeRecruitingNCT00001849Phase 1, Phase 2
19Study to Evaluate CORT125134 in Patients With Cushing's SyndromeRecruitingNCT02804750Phase 2
20Study of Adrenalectomy Versus Observation for Subclinical HypercortisolismRecruitingNCT02001051Phase 2
21Mifepristone for Metabolic SyndromeRecruitingNCT01419535Phase 1, Phase 2
22Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrsNot yet recruitingNCT02611258Phase 2
23Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) SecretionTerminatedNCT00422201Phase 2
24Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine OriginTerminatedNCT00958841Phase 2
25Pasireotide Therapy in Patients With Nelson's SyndromeTerminatedNCT01617733Phase 2
26Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's SyndromeUnknown statusNCT00682084
27Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's SyndromeUnknown statusNCT00004343
28Study of Depression, Peptides, and Steroids in Cushing's SyndromeUnknown statusNCT00004334
29Anesthesia Management of Retroperitoneal AdrenalectomiesUnknown statusNCT00894335
30Long Term Post Operative Follow-Up of Cushing SyndromeCompletedNCT00029952
31Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing SyndromeCompletedNCT00001453
32Hippocampal Complex Volume and Memory Dysfunction in Cushing's SyndromeCompletedNCT00004326
33In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in ManCompletedNCT02889224
34Study of Cushing's Syndrome Not Related to ACTH ProductionCompletedNCT00006278
35Cognition, Steroids, and Imaging in Cushings DiseaseCompletedNCT00081341
36Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal InsufficiencyCompletedNCT00001180
37The Factors Associated With the Recurrence in Patients With Cushing DiseaseCompletedNCT02233335
38Heart Disease Risk Factors in Major DepressionCompletedNCT00001969
39Metabolic Effects of Acute Cortisol Withdrawal in Adrenal FailureCompletedNCT00442390
40To Study Polycystic Ovary Syndrome in Taiwanese WomenCompletedNCT01256944
41Adolescence, Puberty, and Emotion RegulationCompletedNCT00016731
42Dynamics of Leptin and Endocrine FunctionCompletedNCT00001543
43Study of Adrenal Gland TumorsRecruitingNCT00005927
44Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children.RecruitingNCT02646553
45The Accuracy of Late Night Urinary Free Cortisol/Creatinine and Hair Cortisol in Cushing's Syndrome DiagnosisRecruitingNCT02791698
46Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal IncidentalomaRecruitingNCT01382420
47Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal TumorsRecruitingNCT02543697
48Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After SurgeryRecruitingNCT02922257
49Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome SubjectsRecruitingNCT02574793
50Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings SyndromeRecruitingNCT01246739

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: cushing syndrome

Genetic Tests for Cushing's Syndrome

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Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome27

Anatomical Context for Cushing's Syndrome

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MalaCards organs/tissues related to Cushing's Syndrome:

36
Pituitary, Adrenal gland, Testes, Bone, Cortex, Adrenal cortex, Skin

Publications for Cushing's Syndrome

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Articles related to Cushing's Syndrome:

(show top 50)    (show all 1016)
idTitleAuthorsYear
1
Body composition in pituitary, adrenal and iatrogenic Cushing's syndrome and effects of DHEAS levels. (27696526)
2017
2
Increased prevalence of obstructive sleep apnea in patients with Cushing's syndrome compared with weight- and age-matched controls. (27932409)
2017
3
Cushing's syndrome managed by endoscopic ultrasound-guided radiofrequency ablation of adrenal gland adenoma. (28068682)
2017
4
Cushing's syndrome: a practical approach to diagnosis and differential diagnoses. (28069628)
2017
5
Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels. (27932530)
2017
6
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection. (28060049)
2017
7
Towards a universally accepted definition of subclinical Cushing's syndrome - subclinical autonomous hypercortisolism. (27662258)
2016
8
Unusual Cushing's Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma. (28044110)
2016
9
Adrenal Insufficiency under Standard Dosage of Glucocorticoid Replacement after Unilateral Adrenalectomy for Cushing's Syndrome. (27375907)
2016
10
A Novel Mutation in the type II+ Regulatory Subunit of Protein Kinase A (PRKAR1A) in a Cushing's Syndrome Patient with Primary Pigmented Nodular Adrenocortical Disease. (27580546)
2016
11
Skin manifestations of Cushing's syndrome. (27943005)
2016
12
Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome. (27766686)
2016
13
Serum Adiponectin Level as a Predictor of Subclinical Cushing's Syndrome in Patients with Adrenal Incidentaloma. (27656211)
2016
14
Cushing's syndrome due to ectopic ACTH secretion. (27387249)
2016
15
Cushing's Syndrome: Screening and Diagnosis. (27160717)
2016
16
Resolution of the physical features of Cushing's syndrome in a patient with a cortisol secreting adrenocortical adenoma after unilateral adrenalectomy. (27126097)
2016
17
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome. (27403928)
2016
18
Glucocorticoid Regulation of Food-Choice Behavior in Humans: Evidence from Cushing's Syndrome. (26903790)
2016
19
Mifepristone Improves Octreotide Efficacy in Resistant Ectopic Cushing's Syndrome. (26989527)
2016
20
Brain metabolite abnormalities in ventromedial prefrontal cortex are related to duration of hypercortisolism and anxiety in patients with Cushing's syndrome. (27103571)
2016
21
Left ventricular geometry and 24-h blood pressure profile in Cushing's syndrome. (27179657)
2016
22
MECHANISMS IN ENDOCRINOLOGY: Tissue-Specific Activation of Cortisol in Cushing's Syndrome. (26957494)
2016
23
Role of "old" pharmacological agents in the treatment of Cushing's syndrome. (27086313)
2016
24
A probabilistic model for Cushing's syndrome screening in at-risk populations: a prospective multicenter study. (27490917)
2016
25
Reduced DNA methylation of FKBP5 in Cushing's syndrome. (27664120)
2016
26
Cushing's Syndrome From Pituitary Microadenoma and Pulmonary Nodules. (26906124)
2016
27
Cushing's Syndrome And Steroid Dementia. (27515536)
2016
28
Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy". (27901643)
2016
29
Complications of Cushing's syndrome: state of the art. (27177728)
2016
30
Lower extremity insufficiency fractures: an underappreciated manifestation of endogenous Cushing's syndrome. (27525744)
2016
31
Six controversial issues on subclinical Cushing's syndrome. (27406391)
2016
32
Unusual cause of paraparesis in a patient with Cushing's syndrome. (27655879)
2016
33
Structured nursing educational programs improve quality of life outcomes in patients with Cushing's syndrome. (27048358)
2016
34
Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016). (27454103)
2016
35
Markers of atherosclerosis in patients with Cushing's syndrome: a meta-analysis of literature studies. (27763781)
2016
36
Vandetanib induces a marked anti-tumor effect and amelioration of ectopic Cushing's syndrome in a medullary thyroid carcinoma patient. (27855236)
2016
37
Ketoconazole and endogenous Cushing's syndrome. Effective but tricky to use. (27152395)
2016
38
Evaluation of an automated chemiluminescent immunoassay for salivary cortisol measurement. Utility in the diagnosis of Cushing's syndrome. (27580182)
2016
39
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. (27865872)
2016
40
Cushing's Syndrome: Where and How to Find It. (27211887)
2016
41
Iatrogenic Cushing's Syndrome After Topical Steroid Therapy for Psoriasis. (26955131)
2016
42
Cushing's syndrome. (27551694)
2016
43
Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing's Syndrome. (28018289)
2016
44
The degree of urinary hypercortisolism is not correlated with the severity of cushing's syndrome. (26965912)
2016
45
E2F1-mediated human POMC expression in ectopic Cushing's syndrome. (27935805)
2016
46
Adrenal Cushing's syndrome in pregnancy: Clinical and molecular characterisation of a case. (27512490)
2016
47
Acute Exacerbation of Idiopathic Pulmonary Fibrosis Following Treatment for Cushing's Syndrome. (26875965)
2016
48
A Cushing's syndrome patient's severe insomnia and morning blood pressure surge both improved after her left adrenal tumor resection. (27465471)
2016
49
Italian Society for the Study of Diabetes (SID)/Italian Endocrinological Society (SIE) guidelines on the treatment of hyperglycemia in Cushing's syndrome and acromegaly. (26905474)
2016
50
The diagnostic value of late-night salivary cortisol for diagnosis of subclinical Cushing's syndrome. (26884297)
2016

Variations for Cushing's Syndrome

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Clinvar genetic disease variations for Cushing's Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1GNASNM_000516.5(GNAS): c.601C> T (p.Arg201Cys)SNVPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
2GNASNM_000516.5(GNAS): c.602G> A (p.Arg201His)SNVPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
3GNASNM_000516.5(GNAS): c.601C> A (p.Arg201Ser)SNVPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420

Expression for genes affiliated with Cushing's Syndrome

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Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

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Pathways related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
110.0GNAS, NR3C1
210.0CRH, POMC
39.9GNAS, PRKACA
49.7CRH, GNAS, POMC
59.6NR3C1, POMC, PRKACA
6
Show member pathways
9.6GNAS, PRKACA, PRKAR1A
7
Show member pathways
9.6GNAS, PRKACA, PRKAR1A
89.6GNAS, PRKACA, PRKAR1A
99.6GNAS, PRKACA, PRKAR1A
109.6GNAS, PRKACA, PRKAR1A
119.6POMC, PRKACA, PRKAR1A
12
Show member pathways
9.3CRH, GNAS, PRKACA, PRKAR1A
139.3NR3C1, PRKACA, PRKAR1A, SST
149.1GH1, GNAS, PRKACA, PRKAR1A
15
Show member pathways
9.0HSD11B1, HSD11B2, POMC
16
Show member pathways
8.8GIPR, GNAS, MC2R, PRKACA
17
Show member pathways
8.6CRH, GH1, GNAS, POMC, PRKACA, PRKAR1A
187.8CRH, GIPR, GNAS, MC2R, PDE11A, PDE8B
19
Show member pathways
7.6CRH, GH1, GIPR, GNAS, MC2R, NR3C1
20
Show member pathways
6.1CRH, GH1, GIPR, GNAS, MC2R, NR3C1

GO Terms for genes affiliated with Cushing's Syndrome

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Cellular components related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cAMP-dependent protein kinase complexGO:000595210.3PRKACA, PRKAR1A
2ciliary baseGO:009754610.1PRKACA, PRKAR1A
3plasma membrane raftGO:00448539.8PRKACA, PRKAR1A

Biological processes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:000862810.5CRH, SST
2activation of protein kinase A activityGO:003419910.5PRKACA, PRKAR1A
3cAMP catabolic processGO:000619810.3PDE11A, PDE8B
4positive regulation of cAMP biosynthetic processGO:00308199.8CRH, GIPR, MC2R
5glucocorticoid biosynthetic processGO:00067049.6CRH, HSD11B1, HSD11B2
6response to drugGO:00424939.3CRH, GNAS, HSD11B2, SST

Molecular functions related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1corticotropin-releasing hormone receptor 1 bindingGO:005143010.5CRH, GNAS
2cAMP bindingGO:003055210.4PDE11A, PRKAR1A
33,5-cyclic-AMP phosphodiesterase activityGO:000411510.2PDE11A, PDE8B
43,5-cyclic-nucleotide phosphodiesterase activityGO:000411410.2PDE11A, PDE8B
511-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00038459.9HSD11B1, HSD11B2
6hormone activityGO:00051799.1CRH, GH1, POMC, SST

Sources for Cushing's Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet