MCID: CSH001
MIFTS: 80

Cushing's Syndrome malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Cancer diseases categories
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Summaries for Cushing's Syndrome

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8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Cushing's Syndrome, also known as cushing syndrome, is related to adrenocortical carcinoma and acth-secreting pituitary adenoma, and has symptoms including myopathy, osteonecrosis/bone infarction and hypernatremia. An important gene associated with Cushing's Syndrome is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Selected targets of CREB1. The drugs fludrocortisone and fluorocortisol acetate and the compounds pitressin and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and testes, and related mouse phenotypes are hematopoietic system and adipose tissue.

Disease Ontology:8 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

NIH Rare Diseases:43 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. symptoms of cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor. last updated: 2/26/2013

MedlinePlus:34 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:65 Cushing\'s syndrome describes the signs and symptoms associated with prolonged exposure to... more...

Aliases & Classifications for Cushing's Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 49Orphanet, 34MedlinePlus, 22GTR, 45Novoseek, 62UMLS, 21Genetics Home Reference, 10DISEASES, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
cushing syndrome:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

cushing's syndrome 8 43 44 49 34
cushing syndrome 8 43 22 45 49 62
hypercortisolism 43 21 49
hyperadrenocorticism 43 49
adrenal hyperfunction resulting from pituitary acth excess 43
pituitary-dependant hypercortisolism disorder 21
ectopic adrenocorticotropic hormone syndrome 43
nodular primary adrenocortical dysplasia 43
pituitary-dependent cushing's disease 62
pituitary-dependant hypercortisolism 21
pituitary-dependant cushing syndrome 21
pituitary acth hypersecretion 21
adrenal gland hyperfunction 62
pituitary cushing syndrome 21
adrenal cortical adenoma 62
suprarenogenic syndrome 8
adrenal cortex adenoma 43
acth syndrome, ectopic 62
ectopic acth syndrome 43
pituitary basophilism 8
acth syndrome ectopic 45
cushings syndrome 10
cushing disease 21


External Ids:

Disease Ontology8 DOID:12252
MeSH35 D003480
ICD9CM27 255.0
NCIt40 C2969
MESH via Orphanet36 D000308, D003480
SNOMED-CT via Orphanet59 275437005, 47270006
ICD10 via Orphanet26 E24.0, E24.1, E24.2 E24.3, E24.4, E24.8, E24.9, more
UMLS via Orphanet63 C0001622, C0010481
ICD1025 E24.3

Related Diseases for Cushing's Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.6POMC, CYP11B1
2acth-secreting pituitary adenoma30.6POMC, CRH
3nelson syndrome30.4POMC, SST, CRH
4zollinger-ellison syndrome30.3CHGA, SST
5adrenal carcinoma30.3POMC
6adrenal gland hyperfunction30.3POMC, GIPR, CRH, SST
7hypogonadism30.3CRH, POMC, LHCGR
8lung cancer30.2SST, POMC, CHGA
9leydig cell tumor30.2POMC, LHCGR
10hyperandrogenism30.2POMC, CRH, LHCGR
11adrenal adenoma30.2CYP11B1, MC2R, POMC, GIPR, CRH, CHGA
12hyperaldosteronism30.2CYP11B1, POMC
13adenoma30.2CHGA, SST, GIPR, CRH, GHSR, POMC
14congenital adrenal hyperplasia30.1CYP11B1, MC2R, POMC, CRH
15ganglioneuroma30.0POMC, CHGA
16gastrinoma30.0CHGA, SST
17pituitary adenoma30.0POMC, GHSR, CHGA, CRH, SST, MC2R
18neuroendocrine tumor30.0SST, CHGA, POMC
19hyperprolactinemia30.0POMC, SST, CRH
20neuroendocrine carcinoma30.0CHGA, SST
21obesity30.0GHSR, POMC, MC2R, CRH, HSD11B1, GIP
22conn's syndrome30.0POMC, CYP11B1
23pheochromocytoma29.9POMC, CRH, SST, CHGA
24acromegaly29.9SST, HSD11B1, CRH, GHSR, POMC
25diabetes mellitus29.9GIP, POMC, SST, HSD11B1, GIPR
26hypertension29.8POMC, CRH, HSD11B1, CYP11B1
27hypoglycemia29.8POMC, GIP, CHGA, SST, CRH
28small cell carcinoma10.4
29cushing syndrome due to ectopic acth secretion10.4
30acth-independent macronodular adrenal hyperplasia10.4
31cushing syndrome, acth-independent adrenal, somatic10.3
32mccune albright syndrome10.3
33primary pigmented nodular adrenocortical disease10.3
34cervicitis10.3
35pancreatitis10.3
36thyroiditis10.3
37small cell carcinoma of the bladder10.3
38olfactory neuroblastoma10.3
39large cell neuroendocrine carcinoma10.1
40nocardiosis10.1
41lymphangitis10.1
42clear cell sarcoma10.1
43hypokalemia10.1
44pituitary-dependent cushing's disease10.1
45adenocarcinoma10.1
46gastric adenocarcinoma10.1
47hepatoblastoma10.1
48sarcoma10.1
49thymic hyperplasia10.1
50pituitary carcinoma10.1POMC

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms for Cushing's Syndrome

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49Orphanet
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Symptoms:

49 (show all 41)
  • myopathy
  • osteonecrosis/bone infarction
  • hypernatremia
  • hypercalcemia
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • adrenal neoplasm/tumor/carcinoma/cancer
  • telangiectasiae of the skin
  • acne/acnea
  • psychosis/schizophrenia/maniac disorder
  • obnubilation/coma/lethargia/desorientation
  • sterility/hypofertility
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • chronic arterial hypertension
  • hirsutism/hypertrichosis/increased body hair
  • ecchymoses
  • purpura/petichiae
  • striae
  • cushingoid morphotype
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • abnormal fat distribution/lipodystrophy
  • truncal obesity
  • impotence/painful erection/priapism/erection troubles
  • thin skin
  • diabetes mellitus
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • sleep and vigilance disorders
  • precocious menopause/secondary amenorrhea
  • cortico-adrenal hyperplasia/hypersecretion
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • cardiomyopathy/hypertrophic/dilated
  • acute abdominal pain/colic
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • cataract/lens opacification
  • asthenia/fatigue/weakness
  • hypokalemia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • mutiple fractures/bone fragility
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • muscle weakness/flaccidity
  • round face

Drugs & Therapeutics for Cushing's Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cushing's Syndrome

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22GTR
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Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

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33MalaCards
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MalaCards organs/tissues related to Cushing's Syndrome:

33
Pituitary, Adrenal gland, Testes, Cortex, Adrenal cortex, Skin, Kidney, Bone, Thyroid, Lung, Prostate, Heart, Liver, Ovary, Thymus, Pancreatic islet, Pancreas, Eye, Hypothalamus, Endothelial, Skeletal muscle, Colon, Adipocyte, Cervix, Testis

Animal Models for Cushing's Syndrome or affiliated genes

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37MGI
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Publications for Cushing's Syndrome

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52PubMed
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Articles related to Cushing's Syndrome:

(show top 50)    (show all 872)
idTitleAuthorsYear
1
Screening for Cushing's syndrome: new immunoassays require adequate normative data. (23417245)
2013
2
Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome. (24083069)
2013
3
Hypercoagulable state in Cushing's syndrome is reversible following remission. (22724622)
2013
4
Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy. (22767639)
2012
5
Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. (22190002)
2012
6
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
7
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
8
Effect of Cushing's syndrome - Endogenous hypercortisolemia on cardiovascular autonomic functions. (21177144)
2011
9
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
10
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
11
Bone turnover in patients with endogenous Cushing's syndrome before and after successful treatment. (19513576)
2010
12
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
13
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
14
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. (20829630)
2010
15
Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone]. (19419710)
2009
16
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
17
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. (18827959)
2008
18
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17223996)
2007
19
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
20
Cushing's syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? (18183788)
2007
21
Role for laparoscopic adrenalectomy in patients with Cushing's syndrome. (18209873)
2007
22
Pharmacological management of Cushing's syndrome: an update. (18209872)
2007
23
Cushing's Syndrome: important issues in diagnosis and management. (16868050)
2006
24
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
25
18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome. (15817906)
2005
26
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
27
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome. (14606715)
2003
28
Meningioma presenting with Cushing's syndrome: an unusual clinical presentation. (12509860)
2003
29
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia. (12744099)
2003
30
Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome? (14669823)
2003
31
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. (14671177)
2003
32
A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of Cushing's syndrome: a comparison with the standard high-dose dexamethasone suppression test. (12523812)
2002
33
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
34
Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. (11701732)
2001
35
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
36
Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH. (11248744)
2001
37
The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies. (11004721)
2000
38
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
39
Enhanced Na+/H+ exchange in Cushing's syndrome reflects functional hypermineralocorticoidism. (9794723)
1998
40
Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. (9013748)
1996
41
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
42
A case of splenic artery aneurysm with Cushing's syndrome. (8818750)
1996
43
Psychiatric aspects of Cushing's syndrome. (8759496)
1996
44
Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: pituitary-adrenocortical function and immunohistochemistry. (8774967)
1995
45
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
46
Cushing's syndrome associated with lung tumors. (1313485)
1992
47
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
48
Primary bilateral adrenocortical causes of Cushing's syndrome. (1745978)
1991
49
The corticotropin-releasing factor test in the differential diagnosis of Cushing's syndrome: a comparison with the lysine-vasopressin test. (2239082)
1990
50
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970

Variations for Cushing's Syndrome

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Expression for genes affiliated with Cushing's Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cushing's Syndrome

Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

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Sources:
50PathCards, 51PharmGKB, 12EMD Millipore, 55Reactome, 60Thomson Reuters, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Cushing's Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9POMC, CRH
29.3CRH, CHGA, MC2R
3
Show member pathways
9.2POMC, GIPR, GIP, CRH
4
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.1HSD11B1, CYP11B1
59.0CRH, POMC, CYP11B1
6
Show member pathways
8.8POMC, HSD11B1, CYP11B1
7
Show member pathways
Peptide GPCRs38
8.5AVPR1B, LHCGR, MC2R, GHSR
88.1LHCGR, MC2R, POMC, GIPR, GIP, CRH
9
Show member pathways
6.8AVPR1B, LHCGR, MC2R, POMC, GIPR, GIP
10
Show member pathways
6.8CRH, AVPR1B, LHCGR, MC2R, POMC, GIPR

Compounds for genes affiliated with Cushing's Syndrome

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Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1pitressin459.9SST, POMC, CRH
25-hydroxytryptophan459.8CHGA, SST, CRH
35-hydroxyindoleacetic acid45 2410.8CRH, CHGA, SST
4hcrh459.8GHSR, CRH, POMC
5desmopressin45 61 29 1112.7CRH, POMC, AVPR1B
6ghrp-629 4510.7GHSR, SST
7acth 1-24459.6MC2R, POMC, CRH
8lanreotide45 2910.6CHGA, SST, GHSR
9naloxone45 29 51 1112.6CRH, SST, POMC
105-hydroxytryptamine459.5CHGA, SST, POMC, CRH
11clonidine45 51 29 1112.4SST, CHGA, POMC
1211 deoxycortisol459.4CYP11B1, CRH, POMC
13hexarelin45 2910.4CRH, GHSR, SST, POMC
14gaba459.3POMC, CRH, SST, CHGA
1517-hydroxyprogesterone45 2410.3CRH, POMC, CYP11B1
16dehydroepiandrosterone sulfate459.3CRH, MC2R, POMC
17spironolactone45 61 29 51 1113.3CRH, POMC, CYP11B1
18isoproterenol45 1110.3CHGA, LHCGR, CRH, SST
19cortisol29 2410.2POMC, CYP11B1, HSD11B1
20epinephrine45 24 1111.2SST, CHGA, POMC, CRH, GIP
21gnrh459.1LHCGR, CRH, SST, CHGA, POMC
22dhea459.1MC2R, POMC, CRH, HSD11B1
23octreotide45 61 29 1112.1POMC, CHGA, SST, GHSR, CRH
24ketoconazole45 29 24 1112.0CRH, SST, CYP11B1, POMC
25dopamine45 29 24 1112.0GHSR, SST, CHGA, POMC, CRH
26cortisone45 249.9POMC, CYP11B1, HSD11B1, CRH
2711b-Hydroxyandrost-4-ene-3,17-dione248.8HSD11B1, CYP11B1
28pge2458.8POMC, CRH, HSD11B1, LHCGR, SST
29histidine458.6GIP, LHCGR, CHGA, CYP11B1
30estrogen458.4CHGA, GHSR, CRH, POMC, HSD11B1, LHCGR
3111beta-hydroxysteroid458.3POMC, CYP11B1, HSD11B1, CRH, MC2R
32glucose458.3GHSR, HSD11B1, POMC, GIP, CHGA, SST
33androstenedione45 249.3CRH, POMC, MC2R, HSD11B1, CYP11B1
343beta-hydroxysteroid458.2LHCGR, MC2R, POMC, CYP11B1, HSD11B1
35corticosterone45 61 2410.2AVPR1B, CRH, POMC, HSD11B1, LHCGR, CYP11B1
36progesterone45 29 61 24 1112.2CYP11B1, POMC, HSD11B1, LHCGR, CRH, CHGA
37cyclic amp45 249.0LHCGR, CRH, GIP, MC2R, CYP11B1, CHGA
38estradiol45 24 119.9HSD11B1, CYP11B1, POMC, LHCGR, CRH, GHSR
39metyrapone45 61 119.9CRH, MC2R, POMC, SST, CYP11B1, HSD11B1
40cholesterol45 29 24 1110.8CHGA, MC2R, CYP11B1, LHCGR, HSD11B1
41adenylate457.7SST, GIP, MC2R, POMC, CRH, GHSR
42alanine457.5HSD11B1, LHCGR, CYP11B1, MC2R, CRH, GIP
43hydrocortisone45 3 61 1110.4MC2R, CYP11B1, HSD11B1, POMC, SST, GHSR
44dexamethasone45 51 29 1110.1SST, CHGA, CRH, POMC, HSD11B1, CYP11B1
45arginine457.1AVPR1B, LHCGR, POMC, GIP, CHGA, SST
46steroid457.1CRH, GHSR, MC2R, CHGA, LHCGR, POMC
47ribonucleic acid456.8MC2R, GIPR, CHGA, GHSR, CRH, POMC
48forskolin45 51 118.7LHCGR, MC2R, POMC, GIP, CYP11B1, HSD11B1
49testosterone45 61 24 119.7GHSR, SST, CHGA, MC2R, HSD11B1, CRH
50acth456.1SST, CYP11B1, LHCGR, GHSR, MC2R, POMC

GO Terms for genes affiliated with Cushing's Syndrome

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16Gene Ontology
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Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.5GIP, POMC
2extracellular regionGO:0055768.8CRH, SST, CHGA, GIP, POMC

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to axon injuryGO:04867810.0GIP, GIPR
2long-term synaptic potentiationGO:06029110.0GIP, CRH
3hormone-mediated apoptotic signaling pathwayGO:00862810.0CRH, SST
4positive regulation of insulin secretionGO:0320249.9GIPR, GIP
5positive regulation of cAMP-mediated signalingGO:0439509.9GIP, LHCGR
6activation of adenylate cyclase activityGO:0071909.9GIPR, LHCGR
7response to amino acidGO:0432009.9GIP, SST
8endocrine pancreas developmentGO:0310189.9GIP, GIPR
9positive regulation of cAMP biosynthetic processGO:0308199.7CRH, MC2R
10generation of precursor metabolites and energyGO:0060919.6GIPR, POMC
11G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.4LHCGR, MC2R
12regulation of blood pressureGO:0082179.4CYP11B1, POMC, CHGA
13response to drugGO:0424939.3CRH, SST, GIP
14steroid metabolic processGO:0082029.1HSD11B1, CYP11B1
15glucocorticoid biosynthetic processGO:0067049.1CRH, HSD11B1, CYP11B1
16G-protein coupled receptor signaling pathwayGO:0071868.4GHSR, SST, MC2R, LHCGR, AVPR1B

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:0170469.7GHSR, GIPR
2hormone activityGO:0051798.8CRH, SST, GIP, POMC

Products for genes affiliated with Cushing's Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cushing's Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet