MCID: CSH001
MIFTS: 76

Cushing's Syndrome malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Cancer diseases categories

Aliases & Classifications for Cushing's Syndrome

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 21Genetics Home Reference, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 32MedlinePlus, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Cushing's Syndrome, Aliases & Descriptions:

Name: Cushing's Syndrome 9 41 42 32
Cushing Syndrome 9 41 43 60
Cushing Disease 21 47 22
Cushings Syndrome 41 11
Hypercortisolism 41 21
Adrenal Hyperfunction Resulting from Pituitary Acth Excess 41
Pituitary-Dependant Hypercortisolism Disorder 21
Ectopic Adrenocorticotropic Hormone Syndrome 41
Nodular Primary Adrenocortical Dysplasia 41
Pituitary-Dependent Cushing's Disease 60
Pituitary Dependent Cushing Syndrome 47
Pituitary-Dependant Hypercortisolism 21
Pituitary-Dependant Cushing Syndrome 21
 
Pituitary Corticotroph Micro-Adenoma 47
Corticotroph Pituitary Adenoma 47
Pituitary Acth Hypersecretion 21
Adrenal Gland Hyperfunction 60
Pituitary Cushing Syndrome 21
Adrenal Cortical Adenoma 60
Suprarenogenic Syndrome 9
Adrenal Cortex Adenoma 41
Acth Syndrome, Ectopic 60
Ectopic Acth Syndrome 41
Pituitary Basophilism 9
Acth Syndrome Ectopic 43
Hyperadrenocorticism 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
cushing disease:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:12252
NCIt38 C2969
MeSH33 D003480
ICD9CM27 255.0
Orphanet47 96253
MESH via Orphanet34 D047748
ICD10 via Orphanet26 E24.0
UMLS via Orphanet61 C0221406
ICD1025 E24, E24.3

Summaries for Cushing's Syndrome

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NINDS:42 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards based summary: Cushing's Syndrome, also known as cushing syndrome, is related to acth-independent macronodular adrenal hyperplasia and familial glucocorticoid deficiency, and has symptoms including round face, thin skin and hypercortisolism. An important gene associated with Cushing's Syndrome is GNAS (GNAS complex locus), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Basal cell carcinoma. The drugs fludrocortisone and fluorocortisol acetate and the compounds pitressin and hcrh have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and skin, and related mouse phenotypes are liver/biliary system and adipose tissue.

Disease Ontology:9 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

NIH Rare Diseases:41 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). it most commonly affects adults between age 20 and 50 years. signs and symptoms of cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. affected women may also experience irregular menstrual periods and increased growth of body and facial hair. this condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors. last updated: 11/28/2014

MedlinePlus:32 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

Wikipedia:63 Cushing\'s syndrome, also known as hypercortisolism, Itsenko-Cushing syndrome, and hyperadrenocorticism,... more...

Related Diseases for Cushing's Syndrome

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Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1acth-independent macronodular adrenal hyperplasia31.2GNAS
2familial glucocorticoid deficiency31.1MC2R, POMC
3adrenal carcinoma31.0POMC
4adrenocortical carcinoma31.0CYP11B1, POMC
5zollinger-ellison syndrome30.9SST, CHGA
6nelson syndrome30.9POMC, SST, CRH
7pituitary carcinoma30.8POMC
8hypogonadism30.8LHCGR, POMC, CRH
9pituitary-dependent cushing's disease30.7CRH, POMC
10congenital adrenal hyperplasia30.7CYP11B1, MC2R, POMC, CRH
11lung cancer30.6POMC, CHGA, SST, SYP
12hyperaldosteronism30.5CYP11B1, HSD11B2, POMC
13conn's syndrome30.5CYP11B1, POMC
14ganglioneuroma30.5POMC, CHGA, SYP
15multiple endocrine neoplasia 130.4SST, CHGA, GNAS
16gastrinoma30.4CHGA, SST, SYP
17neuroendocrine tumor30.4CHGA, SST, SYP
18hypothyroidism30.4GHSR, POMC, GNAS
19adrenal gland hyperfunction30.4CRH, SST, GIPR, POMC
20leydig cell tumor30.2LHCGR, GNAS, POMC
21hypoglycemia30.2POMC, GIP, CHGA, SST, CRH
22thyroid cancer30.2GNAS, CHGA, SST
23hyperprolactinemia30.1GNAS, POMC, SST, CRH
24adenocarcinoma30.1HSD11B1, HSD11B2, CHGA, SST, SYP
25hyperandrogenism30.1LHCGR, GNAS, SULT2A1, POMC, CRH
26pheochromocytoma29.8GNAS, POMC, CHGA, SST, SYP, CRH
27adrenal adenoma29.6CRH, GIPR, POMC, MC2R, SULT2A1, HSD11B2
28obesity29.5GNAS, HSD11B1, HSD11B2, MC2R, POMC, GIP
29pituitary adenoma29.3CRH, SYP, GHSR, SST, CHGA, POMC
30adrenal cortical adenoma29.2POMC, MC2R, SULT2A1, CYP11B1, GIPR, CHGA
31acromegaly29.2AIP, CRH, GHSR, SST, POMC, HSD11B2
32adenoma27.6HSD11B1, GNAS, LHCGR, CYP11B1, AIP, AVPR1B
33pituitary apoplexy10.5POMC
34melancholia10.5POMC, CRH
35gangliocytoma10.5SYP
36somatostatinoma10.5CHGA, SST
37sheehan syndrome10.5POMC, CRH
38major depressive disorder and accelerated response to antidepressant drug treatment10.5CRH
39anorexia nervosa10.5CRH, POMC
40bronchial endocrine tumor10.5POMC, SST
41gonadal disease10.5POMC, CRH
42hypoadrenalism10.5POMC, CRH
43small cell carcinoma10.5
44hyperinsulinemic hypoglycemia, familial, 210.4CHGA, SST
45achalasia-addisonianism-alacrimia syndrome10.4POMC, MC2R
46west syndrome10.4CRH, POMC
47subependymal giant cell astrocytoma10.4SYP
48panic disorder10.4POMC, CRH
49endogenous depression10.4POMC, CRH
50aldosteronism, glucocorticoid-remediable10.4CYP11B1, POMC

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms for Cushing's Syndrome

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Symptoms:

 47 (show all 40)
  • round face
  • thin skin
  • cortico-adrenal hyperplasia/hypersecretion
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • truncal obesity
  • abnormal fat distribution/lipodystrophy
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • cushingoid morphotype
  • acne/acnea
  • hirsutism/hypertrichosis/increased body hair
  • chronic arterial hypertension
  • bruisability
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • sterility/hypofertility
  • diabetes mellitus
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • mutiple fractures/bone fragility
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hypokalemia
  • asthenia/fatigue/weakness
  • cataract/lens opacification
  • visual loss/blindness/amblyopia
  • mild visual loss/impaired visual acuity
  • chronic skin infection/ulcerations/ulcers/cancrum
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • telangiectasiae of the skin
  • onyxis/paronyxis/ungual inflammation
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • cardiomyopathy/hypertrophic/dilated
  • venous thrombosis/phlebitis/thrombophlebitis
  • precocious menopause/secondary amenorrhea
  • facial pain/cephalalgia/migraine
  • sleep and vigilance disorders
  • obnubilation/coma/lethargia/desorientation
  • psychosis/schizophrenia/maniac disorder
  • myopathy
  • osteonecrosis/bone infarction

HPO human phenotypes related to Cushing's Syndrome:

(show all 42)
id Description Frequency HPO Source Accession
1 round face hallmark (90%) HP:0000311
2 thin skin hallmark (90%) HP:0000963
3 hypercortisolism hallmark (90%) HP:0001578
4 truncal obesity hallmark (90%) HP:0001956
5 abnormality of adipose tissue hallmark (90%) HP:0009124
6 erectile abnormalities hallmark (90%) HP:0100639
7 neoplasm of the endocrine system hallmark (90%) HP:0100568
8 decreased fertility typical (50%) HP:0000144
9 nephrolithiasis typical (50%) HP:0000787
10 diabetes mellitus typical (50%) HP:0000819
11 hypertension typical (50%) HP:0000822
12 bruising susceptibility typical (50%) HP:0000978
13 hypertrichosis typical (50%) HP:0000998
14 acne typical (50%) HP:0001061
15 striae distensae typical (50%) HP:0001065
16 muscle weakness typical (50%) HP:0001324
17 recurrent fractures typical (50%) HP:0002757
18 hypokalemia typical (50%) HP:0002900
19 reduced bone mineral density typical (50%) HP:0004349
20 abnormality of immune system physiology typical (50%) HP:0010978
21 cataract occasional (7.5%) HP:0000518
22 secondary amenorrhea occasional (7.5%) HP:0000869
23 hypercortisolism occasional (7.5%) HP:0001578
24 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
25 abdominal pain occasional (7.5%) HP:0002027
26 sleep disturbance occasional (7.5%) HP:0002360
27 hypercalcemia occasional (7.5%) HP:0003072
28 abnormality of lipid metabolism occasional (7.5%) HP:0003119
29 myopathy occasional (7.5%) HP:0003198
30 hypernatremia occasional (7.5%) HP:0003228
31 abnormality of the gastric mucosa occasional (7.5%) HP:0004295
32 reduced consciousness/confusion occasional (7.5%) HP:0004372
33 aseptic necrosis occasional (7.5%) HP:0010885
34 abnormal renal physiology occasional (7.5%) HP:0012211
35 teleangiectasia of the skin occasional (7.5%) HP:0100585
36 neoplasm of the adrenal gland occasional (7.5%) HP:0100631
37 visual impairment occasional (7.5%) HP:0000505
38 paronychia occasional (7.5%) HP:0001818
39 migraine occasional (7.5%) HP:0002076
40 thrombophlebitis occasional (7.5%) HP:0004418
41 generalized hyperpigmentation occasional (7.5%) HP:0007440
42 skin ulcer occasional (7.5%) HP:0200042

Drugs & Therapeutics for Cushing's Syndrome

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Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Cushing's Syndrome

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Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

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MalaCards organs/tissues related to Cushing's Syndrome:

31
Pituitary, Adrenal gland, Skin, Bone, Testes, Cortex, Adrenal cortex, Kidney, Thyroid, Lung, Heart, Liver, Ovary, Prostate, Thymus, Brain, Pancreas, Pancreatic islet, Eye, Skeletal muscle, Colon, Adipocyte, Testis, Cervix, Endothelial, Hypothalamus

Animal Models for Cushing's Syndrome or affiliated genes

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Publications for Cushing's Syndrome

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Articles related to Cushing's Syndrome:

(show top 50)    (show all 920)
idTitleAuthorsYear
1
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. (24571724)
2014
2
Metachronous bilateral adrenocortical functional adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome. (25197412)
2014
3
Screening for Cushing's syndrome: new immunoassays require adequate normative data. (23417245)
2013
4
Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome. (24083069)
2013
5
Hypercoagulable state in Cushing's syndrome is reversible following remission. (22724622)
2013
6
Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy. (22767639)
2012
7
Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. (22190002)
2012
8
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
9
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
10
Effect of Cushing's syndrome - Endogenous hypercortisolemia on cardiovascular autonomic functions. (21177144)
2011
11
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
12
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
13
Bone turnover in patients with endogenous Cushing's syndrome before and after successful treatment. (19513576)
2010
14
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
15
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
16
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. (20829630)
2010
17
Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone]. (19419710)
2009
18
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
19
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. (18827959)
2008
20
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17223996)
2007
21
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
22
Cushing's syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? (18183788)
2007
23
Role for laparoscopic adrenalectomy in patients with Cushing's syndrome. (18209873)
2007
24
Pharmacological management of Cushing's syndrome: an update. (18209872)
2007
25
Cushing's Syndrome: important issues in diagnosis and management. (16868050)
2006
26
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
27
18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome. (15817906)
2005
28
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
29
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome. (14606715)
2003
30
Meningioma presenting with Cushing's syndrome: an unusual clinical presentation. (12509860)
2003
31
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia. (12744099)
2003
32
Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome? (14669823)
2003
33
A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of Cushing's syndrome: a comparison with the standard high-dose dexamethasone suppression test. (12523812)
2002
34
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
35
Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. (11701732)
2001
36
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
37
Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH. (11248744)
2001
38
The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies. (11004721)
2000
39
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
40
Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. (9013748)
1996
41
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
42
A case of splenic artery aneurysm with Cushing's syndrome. (8818750)
1996
43
Psychiatric aspects of Cushing's syndrome. (8759496)
1996
44
Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: pituitary-adrenocortical function and immunohistochemistry. (8774967)
1995
45
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
46
Cushing's syndrome associated with lung tumors. (1313485)
1992
47
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
48
Primary bilateral adrenocortical causes of Cushing's syndrome. (1745978)
1991
49
The corticotropin-releasing factor test in the differential diagnosis of Cushing's syndrome: a comparison with the lysine-vasopressin test. (2239082)
1990
50
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970

Variations for Cushing's Syndrome

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Clinvar genetic disease variations for Cushing's Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1GNAI2NM_002070.3(GNAI2): c.535C> G (p.Arg179Gly)single nucleotide variantPathogenicrs137853226GRCh37Chr 3, 50293694: 50293694
2GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
3GNASNM_001077488.2(GNAS): c.684G> C (p.Gln228His)single nucleotide variantPathogenicrs137854533GRCh37Chr 20, 57484597: 57484597
4AIPNM_003977.2(AIP): c.911G> A (p.Arg304Gln)single nucleotide variantPathogenicrs104894190GRCh37Chr 11, 67258382: 67258382

Cosmic variations for Cushing's Syndrome:

7 (show all 18)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
117661CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
21423013CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
35692CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
496539CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
55664CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
685770CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
75667CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
813154CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
912639CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1029397CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1129399CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
125663CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1313153CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1444915TP53adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1543678TP53adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1627889GNASadrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1723025MEN1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
18584NRASadrenal gland,adrenal gland,adrenal cortical adenoma,NS3

Expression for genes affiliated with Cushing's Syndrome

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Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

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Pathways related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CRH, POMC
2
Show member pathways
9.9GNAI2, POMC, GNAS
39.9GNAS, CRH, GNAI2
4
Show member pathways
9.8GNAS, GNAI2, SST
59.8NR2F1, AIP
6
Show member pathways
9.6POMC, GNAI2, GNAS, LHCGR
7
Show member pathways
9.6CYP11B1, HSD11B1, POMC
8
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
9.5SULT2A1, CYP11B1
9
Show member pathways
9.1GNAS, GNAI2, POMC, GIPR, GIP, CRH
10
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.0HSD11B2, HSD11B1, CYP11B1
118.6GNAS, GNAI2, SULT2A1, POMC, CRH, CYP11B1
128.0POMC, GIPR, CRH, GIP, MC2R, GNAI2
13
Show member pathways
7.0GNAI2, AVPR1B, AVPR2, CRH, GHSR, SST
14
Show member pathways
7.0AVPR2, GNAI2, CRH, GHSR, SST, GIP

Compounds for genes affiliated with Cushing's Syndrome

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Compounds related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1pitressin4310.1SST, POMC, CRH
2hcrh439.9POMC, GHSR, CRH
3acth 1-24439.8CRH, MC2R, POMC
4111in-pentetreotide439.8SYP, SST, CHGA
5terlipressin43 1210.7SST, AVPR1B, AVPR2
6hexarelin43 2810.7GHSR, SST, POMC, CRH
711 deoxycortisol439.6POMC, CRH, CYP11B1
8ketoconazole43 28 24 1212.6SST, CRH, POMC, CYP11B1
9desmopressin43 59 28 1212.5AVPR1B, AVPR2, POMC, CRH
10isoproterenol43 1210.4CRH, LHCGR, GNAS, CHGA, SST
11gnrh439.4CRH, SST, LHCGR, CHGA, GNAS, POMC
12octreotide43 59 28 1212.3CHGA, CRH, GHSR, SST, POMC, GNAS
135-hydroxytryptamine439.3CHGA, SST, SYP, CRH, POMC
1411b-Hydroxyandrost-4-ene-3,17-dione249.3CYP11B1, HSD11B2, HSD11B1
15dehydroepiandrosterone sulfate439.2POMC, CRH, MC2R, SULT2A1
16cortisol28 2410.1CYP11B1, HSD11B1, HSD11B2, POMC
17spironolactone43 59 28 49 1213.1CYP11B1, HSD11B2, POMC, CRH
18metyrapone43 59 1211.1CRH, POMC, MC2R, HSD11B1, CYP11B1, SST
19betamethasone43 1210.1SYP, CRH, HSD11B2, POMC
20pge2439.0SST, POMC, HSD11B1, LHCGR, GNAS, CRH
21doca439.0HSD11B2, CYP11B1, POMC
22cortisone43 249.9CRH, POMC, CYP11B1, HSD11B1, HSD11B2
23guanine43 24 1210.8SULT2A1, SYP, GNAS, LHCGR, CHGA
2411beta-hydroxysteroid438.6HSD11B1, CYP11B1, MC2R, HSD11B2, POMC, CRH
25androstenedione43 249.5CYP11B1, CRH, POMC, HSD11B1, MC2R, HSD11B2
26histidine438.5CYP11B1, GNAS, GIP, CHGA, AVPR2, SYP
27norepinephrine43 24 1210.4GNAS, POMC, CHGA, SST, CRH, HSD11B2
28corticosterone43 59 2410.4HSD11B2, HSD11B1, LHCGR, CYP11B1, AVPR1B, POMC
29dhea438.3POMC, HSD11B1, CRH, MC2R, HSD11B2, SULT2A1
30glutamate438.3SST, SYP, CRH, GNAS, LHCGR, AVPR2
31dopamine43 28 24 1211.2GNAS, SULT2A1, CRH, POMC, SST, GHSR
32alanine438.1LHCGR, GNAS, HSD11B1, MC2R, POMC, AVPR2
33glucose438.0GNAS, HSD11B1, HSD11B2, POMC, GIP, SST
34cyclic amp43 249.0CHGA, MC2R, GIP, SYP, CRH, LHCGR
353beta-hydroxysteroid437.9CYP11B1, MC2R, POMC, LHCGR, SULT2A1, HSD11B2
36hydrocortisone43 2 59 1210.9SST, POMC, MC2R, HSD11B1, CYP11B1, CRH
37cholesterol43 28 24 1210.4CHGA, HSD11B1, LHCGR, CYP11B1, SULT2A1, MC2R
38ribonucleic acid437.3CRH, GHSR, CHGA, HSD11B2, CYP11B1, HSD11B1
39testosterone43 59 24 1210.1HSD11B1, SST, CRH, SYP, MC2R, POMC
40adenylate437.1CRH, AVPR2, LHCGR, POMC, GNAS, HSD11B2
41lipid436.9SULT2A1, HSD11B2, HSD11B1, GNAS, GHSR, GIP
42arginine436.8AVPR2, AVPR1B, CYP11B1, LHCGR, GNAS, HSD11B2
43estrogen436.7LHCGR, POMC, HSD11B2, SULT2A1, HSD11B1, CHGA
44calcium43 49 24 129.6CYP11B1, SYP, GHSR, GIP, MC2R, HSD11B2
45progesterone43 28 59 24 1210.6CYP11B1, LHCGR, GNAS, HSD11B1, HSD11B2, SYP
46estradiol43 24 128.6CRH, NR2F1, POMC, SYP, GHSR, CYP11B1
47dexamethasone43 49 28 129.6CYP11B1, CRH, SYP, HSD11B1, HSD11B2, SULT2A1
48forskolin43 49 128.1GNAS, HSD11B1, HSD11B2, SULT2A1, MC2R, POMC
49steroid435.9NR2F1, CYP11B1, GNAS, HSD11B1, HSD11B2, SULT2A1
50acth435.1HSD11B1, MC2R, POMC, GIPR, CHGA, SST

GO Terms for genes affiliated with Cushing's Syndrome

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Cellular components related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.9GIP, POMC
2endosomeGO:00057689.4AVPR1B, AVPR2, LHCGR
3extracellular regionGO:00055768.8GNAS, POMC, GIP, CHGA, SST, CRH
4plasma membraneGO:00058867.8GIPR, MC2R, GNAI2, GNAS, LHCGR, AIP

Biological processes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:000862810.2CRH, SST
2positive regulation of cAMP-mediated signalingGO:004395010.0GIP, GNAS, LHCGR
3positive regulation of cAMP biosynthetic processGO:00308199.9GNAS, MC2R, CRH
4response to amino acidGO:00432009.9SST, GIP
5response to nutrientGO:00075849.9SST, GIPR, GNAI2
6long-term synaptic potentiationGO:00602919.9CRH, GIP
7regulation of blood pressureGO:00082179.8CYP11B1, POMC, CHGA
8response to axon injuryGO:00486789.7GIP, GIPR
9activation of adenylate cyclase activityGO:00071909.5AVPR2, LHCGR, GNAS, GIPR
10steroid metabolic processGO:00082029.4SULT2A1, HSD11B1, CYP11B1
11response to foodGO:00320949.3GHSR, HSD11B2
12xenobiotic metabolic processGO:00068059.3AIP, CYP11B1, SULT2A1
13female pregnancyGO:00075659.2GNAS, HSD11B2, GIP, CRH
14glucocorticoid biosynthetic processGO:00067049.0CRH, HSD11B2, HSD11B1, CYP11B1
15G-protein coupled receptor signaling pathwayGO:00071869.0AVPR1B, LHCGR, GNAI2, MC2R, SST, GHSR
16signal transductionGO:00071659.0AIP, GNAI2, POMC, GIP, CRH, NR2F1
17response to drugGO:00424938.9CRH, SST, GIP, HSD11B2, GNAS

Molecular functions related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:00170469.8GHSR, GIPR
2G-protein beta/gamma-subunit complex bindingGO:00316839.8GNAI2, GNAS
3vasopressin receptor activityGO:00050009.6AVPR1B, AVPR2
4hormone activityGO:00051799.5GIP, POMC, SST, CRH
511-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00038459.3HSD11B2, HSD11B1

Products for genes affiliated with Cushing's Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cushing's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet