MCID: CSH001
MIFTS: 83

Cushing's Syndrome malady

Endocrine diseases, Reproductive diseases categories

Summaries for Cushing's Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Cushing's Syndrome, also known as cushing syndrome, is related to adrenocortical carcinoma and adrenal adenoma, and has symptoms including cushingoid morphotype, ecchymoses and adrenal neoplasm/tumor/carcinoma/cancer. An important gene associated with Cushing's Syndrome is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs fludrocortisone and fluorocortisol acetate and the compounds acth and steroid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and testes, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

NIH Rare Diseases:42 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. symptoms of cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor. last updated: 2/26/2013

MedlinePlus:33 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:63 Cushing\'s syndrome describes the signs and symptoms associated with prolonged exposure to... more...

Aliases & Classifications for Cushing's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
cushing's syndrome:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

cushing's syndrome 8 42 43 48 33
cushing syndrome 42 22 44 48 60
hypercortisolism 21 48
adrenal hyperfunction resulting from pituitary acth excess 42
pituitary-dependant hypercortisolism disorder 21
ectopic adrenocorticotropic hormone syndrome 42
pituitary-dependent cushing's disease 60
pituitary-dependant hypercortisolism 21
pituitary-dependant cushing syndrome 21
pituitary acth hypersecretion 21
adrenal gland hyperfunction 60
pituitary cushing syndrome 21
adrenal cortical adenoma 60
suprarenogenic syndrome 8
acth syndrome, ectopic 60
adrenal cortex adenoma 42
acth syndrome ectopic 44
ectopic acth syndrome 42
pituitary basophilism 8
hyperadrenocorticism 48
cushings syndrome 10
cushing disease 21


External Ids:

Disease Ontology8 DOID:12252
MeSH34 D003480
NCIt39 C2969
ICD9CM27 255.0
MESH via Orphanet35 D000308, D003480
SNOMED-CT via Orphanet57 275437005, 47270006
ICD10 via Orphanet26 E24.0, E24.1, E24.2 E24.3, E24.4, E24.8, E24.9, more
UMLS via Orphanet61 C0001622, C0010481
ICD1025 E24.3

Related Diseases for Cushing's Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5CYP11B1, POMC
2adrenal adenoma30.4HSD11B2, HSD11B1, CRH, SULT2A1, MC2R, CYP11B1
3acth-secreting pituitary adenoma30.4POMC, CRH
4thyroiditis30.3TRH, POMC
5pancreatitis30.3SST
6thyroid medullary carcinoma30.3POMC, SST, CHGA
7acromegaly30.3CNC, POMC, TRH, SST, GHSR, CRH
8prolactinoma30.2GHSR, CHGA, SST, TRH, POMC
9nelson syndrome30.2CRH, SST, POMC
10adrenal gland hyperfunction30.1CNC, GIPR, POMC, TRH, SST, CRH
11adenocarcinoma30.1HSD11B2, HSD11B1, SYP, CHGA, SST
12hypogonadism30.1LHCGR, CRH, TRH, POMC
13hypothyroidism30.1POMC, TRH, GHSR
14hypokalemia30.1POMC, HSD11B2
15zollinger-ellison syndrome30.1SST, CHGA
16lung cancer30.1SYP, CHGA, SST, POMC
17adenoma30.1HSD11B1, HSD11B2, HSD3BP4, AVPR1B, MC2R, CYP11B1
18pituitary adenoma30.1CRH, GHSR, SYP, CHGA, SST, TRH
19obesity30.1HSD11B2, HSD11B1, CRH, GHSR, TRH, POMC
20congenital adrenal hyperplasia30.1HSD3BP4, CRH, POMC, CYP11B1, MC2R
21leydig cell tumor30.1POMC, LHCGR, HSD3BP4
22adrenal carcinoma30.1POMC
23hyperandrogenism30.1HSD3BP4, LHCGR, CRH, POMC, SULT2A1
24hyperaldosteronism30.1HSD11B2, POMC, CYP11B1
25empty sella syndrome29.9TRH, POMC
26hypoglycemia29.8CRH, CHGA, SST, TRH, POMC, GIP
27diabetes mellitus29.8HSD11B1, SST, POMC, GIPR, GIP
28hypertension29.8CYP11B1, POMC, CRH, HSD11B1, HSD11B2
29neuroendocrine tumor29.8POMC, SST, CHGA, SYP, GHSR
30gastrinoma29.8SYP, CHGA, SST
31ganglioneuroma29.8SYP, CHGA, POMC
32phaeochromocytoma29.8CHGA
33hyperthyroidism29.8TRH, SST
34ganglioneuroblastoma29.8SYP
35pheochromocytoma29.8POMC, SST, CHGA, SYP, CRH
36hypercalcemia29.8CHGA, AVPR2
37neuroendocrine carcinoma29.8SYP, CHGA, SST
38neuroblastoma29.8SYP
39hyperprolactinemia29.8POMC, TRH, SST, CRH
40carney complex29.8POMC
41arthritis29.8POMC
42conn's syndrome29.8POMC, CYP11B1
43small cell carcinoma10.4
44cushing syndrome due to ectopic acth secretion10.4
45pigmentation disease10.3
46acth-independent macronodular adrenal hyperplasia10.3
47mccune albright syndrome10.3
48olfactory neuroblastoma10.2
49bladder carcinoma10.2
50cervicitis10.2

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Clinical Features for Cushing's Syndrome

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48Orphanet
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Symptoms:

48 (show all 41)
  • cushingoid morphotype
  • ecchymoses
  • adrenal neoplasm/tumor/carcinoma/cancer
  • truncal obesity
  • hypernatremia
  • abnormal fat distribution/lipodystrophy
  • purpura/petichiae
  • cataract/lens opacification
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • cortico-adrenal hyperplasia/hypersecretion
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • cardiomyopathy/hypertrophic/dilated
  • asthenia/fatigue/weakness
  • hypokalemia
  • myopathy
  • obnubilation/coma/lethargia/desorientation
  • osteonecrosis/bone infarction
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • muscle weakness/flaccidity
  • diabetes mellitus
  • chronic arterial hypertension
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • telangiectasiae of the skin
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • hypercalcemia
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • round face
  • sterility/hypofertility
  • striae
  • psychosis/schizophrenia/maniac disorder
  • precocious menopause/secondary amenorrhea
  • impotence/painful erection/priapism/erection troubles
  • acute abdominal pain/colic
  • acne/acnea
  • mutiple fractures/bone fragility
  • thin skin
  • hirsutism/hypertrichosis/increased body hair
  • sleep and vigilance disorders

Drugs & Therapeutics for Cushing's Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cushing's Syndrome

Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Search CenterWatch for Cushing's Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cushing's Syndrome

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22GTR
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Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Cushing's Syndrome:

32
Pituitary, Adrenal gland, Testes, Bone, Adrenal cortex, Cortex, Skin, Kidney, Thyroid, Lung, Liver, Prostate, Heart, Ovary, Thymus, Pancreatic islet, Pancreas, Eye, Colon, Skeletal muscle, Adipocyte, Testis, Endothelial, Cervix, Hypothalamus

Animal Models for Cushing's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cushing's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9AVPR1B, HSD11B2, HSD11B1, LHCGR, CRH, GHSR
2MP:000537910.8HSD11B1, LHCGR, CRH, CHGA, TRH, POMC
3MP:000538610.8CRH, LHCGR, HSD11B1, HSD11B2, GHSR, NR2F1
4MP:000537510.6HSD11B1, LHCGR, GHSR, POMC, CYP11B1, MC2R
5MP:000363110.6HSD11B1, CRH, SYP, NR2F1, SST, TRH
6MP:000301210.6POMC, SST, NR2F1, SYP, GHSR, HSD11B2
7MP:000537810.5GHSR, CRH, LHCGR, HSD11B1, CHGA, SST
8MP:000536710.3HSD11B2, LHCGR, CHGA, POMC, CYP11B1, AVPR2

Publications for Cushing's Syndrome

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50PubMed
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Articles related to Cushing's Syndrome:

(show top 50)    (show all 896)
idTitleAuthorsYear
1
Discriminatory value of signs and symptoms in Cushing's syndrome revisited: what has changed in 30 years? (22775352)
2013
2
Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1. (23440982)
2013
3
Neurodegenerative and inflammatory biomarkers in cerebrospinal fluid in patients with Cushing's syndrome in remission. (23733371)
2013
4
Cushing's syndrome: diagnosis and surveillance using salivary cortisol. (21833616)
2012
5
Salivary cortisol as a diagnostic tool for Cushing's syndrome and adrenal insufficiency: improved screening by an automatic immunoassay. (22214924)
2012
6
Edwardsiella tarda sepsis with multiple liver abscesses in a patient with Cushing's syndrome. (22885207)
2012
7
Subclinical Cushing's syndrome: definition and management. (21988204)
2012
8
Cushing's syndrome. (22740318)
2012
9
Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. (22004909)
2012
10
Drugs in the medical treatment of Cushing's syndrome--an update on mifepristone and pasireotide. (22533823)
2012
11
Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. (22466348)
2012
12
Advances in medical therapies for Cushing's syndrome. (22369976)
2012
13
Diagnostic performance of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay in obese and overweight patients referred to exclude Cushing's syndrome. (22447310)
2012
14
Physical signs for the general dental practitioner. Case 97. Cushing's syndrome. (23094575)
2012
15
The estimation of selected endogenous anticoagulation system parameters in patients with subclinical Cushing's syndrome. (21914670)
2011
16
Cushing's syndrome in pregnancy. (22696666)
2011
17
Mortality and morbidity in Cushing's syndrome in New Zealand. (21609352)
2011
18
Resolution of Cushing's syndrome and exacerbation of autoimmune thyroiditis. (21275768)
2011
19
Crossing the other side of the algorithm: a challenging case of adrenal Cushing's syndrome. (22674941)
2011
20
Two different adrenal adenomas causing Cushing's syndrome. (20464053)
2010
21
ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma. (19915020)
2010
22
The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline: commentary from a European perspective. (20375177)
2010
23
Cushing's syndrome with uncontrolled hypertension, occasional hypokalemia, and two pregnancies. (20629814)
2010
24
Cushing's syndrome caused by an ACTH-producing ovarian steroid cell tumor, NOS, in a prepubertal girl. (19191036)
2009
25
Hypokalemia, diabetes mellitus, and hypercortisolemia are the major contributing factors to cardiac dysfunction in adrenal Cushing's syndrome. (19789419)
2009
26
A Case of Acute Aortic Dissection Type B Associated with Cushing's Syndrome. (22505966)
2009
27
Diurnal ACTH and plasma cortisol variations in healthy dogs and in those with pituitary-dependent Cushing's syndrome before and after treatment with retinoic acid. (18692856)
2009
28
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
29
Subclinical Cushing's syndrome associated with an adrenocortical oncocytoma. (18787391)
2008
30
Phaeochromocytoma and mixed corticomedullary tumour - a rare cause of Cushing's syndrome and labile hypertension in a primigravid woman postpartum. (17868399)
2008
31
Two cases of Cushing's syndrome due to overuse of topical steroid in the diaper area. (18950396)
2008
32
Paraneoplastic Cushing's syndrome and nephrotic syndrome in a patient with disseminated small cell lung cancer. (18376237)
2008
33
Cushing's syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? (18183788)
2007
34
Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomy. (17409602)
2007
35
Development of ipsilateral adrenocortical carcinoma sixteen years after resection of an adrenal tumour causing Cushing's syndrome. (15902349)
2005
36
Growth hormone secretion in primary adrenal Cushing's syndrome is disorderly and inversely correlated with body mass index. (15328071)
2005
37
Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. (12519861)
2003
38
An adolescent with food-dependent Cushing's syndrome secondary to ectopic expression of GIP receptor in unilateral adrenal adenoma. (12099397)
2002
39
Importance of the CRH (corticotropin releasing hormone) test in the differential diagnosis of Cushing's syndrome]. (11729609)
2001
40
Evaluation of haemostatic and fibrinolytic markers in patients with Cushing's syndrome and in patients with adrenal incidentaloma. (10961361)
2000
41
Unusual manifestations of cushing's syndrome in a multiple endocrine neoplasia type I kindred. (15251731)
1998
42
Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, Cushing's syndrome, and orthostatic hypotension. (9253310)
1997
43
Adrenal adenoma with bilateral adrenocortical nodular change in a patient with Cushing's syndrome. (9373462)
1997
44
Relapse of Cushing's syndrome following the treatment of primary pigmented nodular adrenocortical disease by unilateral adrenalectomy. (8811225)
1996
45
Cushing's syndrome in medullary thyroid carcinoma. (7615903)
1995
46
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
47
Selective venous sampling directly from cavernous sinus in Cushing's syndrome. (8383143)
1993
48
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
49
Thyrotropin-releasing hormone, chlorpromazine and L-dopa or bromocriptin tests in Cushing's syndrome due to adrenal hyperplasia and adrenal adenoma. (6795309)
1981
50
Cushing's syndrome and dermatomycosis. (13807440)
1959

Genetic Variations for Cushing's Syndrome

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Expression for genes affiliated with Cushing's Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cushing's Syndrome

Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
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Compounds for genes affiliated with Cushing's Syndrome

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1acth4411.2HSD11B2, HSD11B1, HSD3BP4, LHCGR, CRH, GHSR
2steroid4411.1SULT2A1, MC2R, CYP11B1, POMC, CHGA, NR2F1
3testosterone44 59 11 2414.1HSD11B1, HSD3BP4, SULT2A1, MC2R, CYP11B1, POMC
4dexamethasone44 49 28 1114.1CHGA, SYP, GHSR, CRH, HSD3BP4, HSD11B2
5arginine4411.1GHSR, AVPR1B, HSD11B2, LHCGR, CRH, AVPR2
6ribonucleic acid4411.1CHGA, POMC, GIPR, CYP11B1, HSD3BP4, LHCGR
7progesterone44 59 28 11 2415.1HSD11B1, LHCGR, CRH, SYP, HSD3BP4, CHGA
8forskolin44 49 1113.1SULT2A1, MC2R, CYP11B1, GIP, POMC, GHSR
9adenylate4411.1MC2R, AVPR2, TRH, GIP, CHGA, GHSR
10cyclic amp44 2412.0HSD3BP4, CYP11B1, AVPR2, SYP, LHCGR, CRH
11hydrocortisone44 2 59 1114.0MC2R, HSD11B2, HSD11B1, CRH, GHSR, POMC
123beta-hydroxysteroid4411.0CYP11B1, MC2R, POMC, LHCGR, HSD11B2, HSD11B1
13estradiol44 11 2413.0SULT2A1, POMC, TRH, NR2F1, SYP, GHSR
1411beta-hydroxysteroid4411.0MC2R, CYP11B1, POMC, CRH, HSD3BP4, HSD11B1
15corticosterone44 59 2413.0AVPR1B, CRH, LHCGR, HSD11B1, HSD11B2, POMC
16metyrapone59 44 1113.0MC2R, CYP11B1, POMC, SST, HSD11B1, CRH
17dhea4411.0HSD11B1, HSD3BP4, CRH, POMC, SULT2A1, HSD11B2
18dopamine44 28 11 2414.0POMC, GHSR, SYP, TRH, CRH, SST
19androstenedione44 2412.0MC2R, HSD3BP4, HSD11B2, CRH, HSD11B1, POMC
20cholesterol44 28 11 2414.0MC2R, SULT2A1, CYP11B1, CHGA, SYP, HSD11B1
21octreotide44 59 28 1114.0GHSR, CHGA, SST, POMC, TRH, CRH
22calcium44 49 11 2414.0HSD3BP4, LHCGR, GHSR, SYP, CHGA, TRH
23cortisone44 2411.9CRH, HSD11B2, CYP11B1, POMC, HSD11B1
24cortisol28 2411.9HSD11B2, CYP11B1, POMC, HSD11B1
25estrogen4410.9TRH, NR2F1, HSD11B1
26ketoconazole44 28 11 2413.9POMC, SST, CRH, HSD3BP4, CYP11B1
27dehydroepiandrosterone sulfate4410.9SULT2A1, HSD3BP4, CRH, POMC, MC2R
28hexarelin44 2811.9CRH, GHSR, POMC, SST
29doca4410.9HSD3BP4, POMC, HSD11B2, CYP11B1
30gnrh4410.9LHCGR, CRH, CHGA, SST, TRH, POMC
31norepinephrine44 11 2412.9POMC, SYP, CHGA, TRH
32betamethasone44 1111.9POMC, HSD11B2, CRH, SYP
33hcrh4410.9CRH, GHSR, POMC
34gaba4410.9SST, CRH, POMC, SYP, TRH, CHGA
35pitressin4410.9CRH, SST, POMC
3617-hydroxyprogesterone44 2411.8CYP11B1, HSD3BP4, POMC, CRH
37mifepristone44 59 28 1113.8HSD11B2, HSD3BP4, HSD11B1, CRH, POMC
38spironolactone49 44 59 28 1114.8CYP11B1, HSD11B2, POMC, CRH
39desmopressin44 59 28 1113.8AVPR1B, POMC, AVPR2, CRH
40histidine4410.8CHGA, CYP11B1, AVPR2, SYP, LHCGR, GIP
41alanine4410.8CRH, LHCGR, HSD11B1, GIP, AVPR2, MC2R
42terlipressin44 1111.8AVPR1B, SST, AVPR2
43111in-pentetreotide4410.7SYP, CHGA, SST
445-hydroxytryptamine4410.7SST, POMC, CHGA, SYP, CRH
45naloxone44 49 28 1113.7POMC, SST, TRH, CRH
46acetylcholine44 49 28 11 2414.6POMC, TRH, SST, CHGA, SYP, CRH
47clonidine44 28 1112.5POMC, TRH, SST, CHGA
4811 deoxycortisol4410.5CRH, POMC, CYP11B1
49ghrp4410.4GHSR, SST, TRH
50glycyrrhetinic acid44 2411.2HSD11B2, HSD11B1, HSD3BP4

GO Terms for genes affiliated with Cushing's Syndrome

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16Gene Ontology
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Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.5GIP, POMC
2secretory granuleGO:03014110.2POMC, TRH, CHGA

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.8CYP11B1, CRH, HSD11B1, HSD11B2
2G-protein coupled receptor signaling pathwayGO:00718610.8LHCGR, GHSR, SST, MC2R, AVPR1B
3activation of adenylate cyclase activityGO:00719010.8AVPR2, GIPR, LHCGR
4positive regulation of insulin secretionGO:03202410.7GIP, GIPR, TRH
5hormone-mediated apoptotic signaling pathwayGO:00862810.7SST, CRH
6steroid metabolic processGO:00820210.7HSD11B1, CYP11B1, SULT2A1
7response to glucose stimulusGO:00974910.6TRH, GIPR, GIP
8regulation of blood pressureGO:00821710.6CHGA, POMC, CYP11B1
9response to drugGO:04249310.5GIP, SST, CRH, HSD11B2
10positive regulation of cAMP-mediated signalingGO:04395010.5GIP, LHCGR
11response to foodGO:03209410.4HSD11B2, GHSR
12female pregnancyGO:00756510.2GIP, CRH, HSD11B2

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vasopressin receptor activityGO:00500010.5AVPR1B, AVPR2
2hormone activityGO:00517910.5GIP, POMC, SST, CRH
311-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00384510.2HSD11B1, HSD11B2

Products for genes affiliated with Cushing's Syndrome

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  • Antibodies
  • Proteins
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Sources for Cushing's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet