MCID: CSH001
MIFTS: 85

Cushing's Syndrome malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Cancer diseases categories

Summaries for Cushing's Syndrome

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NINDS:44 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards based summary: Cushing's Syndrome, also known as cushing syndrome, is related to acth-independent macronodular adrenal hyperplasia and adrenocortical carcinoma, and has symptoms including round face, thin skin and hypercortisolism. An important gene associated with Cushing's Syndrome is GNAS (GNAS complex locus), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Basal cell carcinoma. The drugs fludrocortisone and fluorocortisol acetate and the compounds pitressin and hcrh have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and skin, and related mouse phenotypes are liver/biliary system and adipose tissue.

Disease Ontology:10 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

NIH Rare Diseases:43 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). it most commonly affects adults between age 20 and 50 years. signs and symptoms of cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. affected women may also experience irregular menstrual periods and increased growth of body and facial hair. this condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors. last updated: 11/28/2014

MedlinePlus:34 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Genetics Home Reference:23 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

Wikipedia:65 Cushing\'s syndrome, also known as hypercortisolism, Itsenko-Cushing syndrome, and hyperadrenocorticism,... more...

Aliases & Classifications for Cushing's Syndrome

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Sources:
62UMLS, 10Disease Ontology, 43NIH Rare Diseases, 44NINDS, 34MedlinePlus, 45Novoseek, 23Genetics Home Reference, 12DISEASES, 49Orphanet, 24GTR, 40NCIt, 35MeSH, 57SNOMED-CT, 29ICD9CM, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Cushing's Syndrome, Aliases & Descriptions:

Name: Cushing's Syndrome 10 43 44 34
Cushing Syndrome 10 43 45 62
Cushings Syndrome 43 12 62
Hypercortisolism 43 23 62
Cushing Disease 23 49 24
Pituitary-Dependant Hypercortisolism Disorder 23 62
Pituitary Basophilism 10 62
Adrenal Hyperfunction Resulting from Pituitary Acth Excess 43
Ectopic Adrenocorticotrophic Hormone Syndrome 62
Ectopic Adrenocorticotropic Hormone Syndrome 43
Nodular Primary Adrenocortical Dysplasia 43
Pituitary-Dependent Cushing's Disease 62
Pituitary Corticotroph Micro-Adenoma 49
Pituitary-Dependant Hypercortisolism 23
 
Pituitary-Dependant Cushing Syndrome 23
Pituitary Dependent Cushing Syndrome 49
Corticotroph Pituitary Adenoma 49
Pituitary Acth Hypersecretion 23
Adrenal Gland Hyperfunction 62
Pituitary Cushing Syndrome 23
Adrenal Cortical Adenoma 62
Suprarenogenic Syndrome 10
Adrenal Cortex Adenoma 43
Acth Syndrome, Ectopic 62
Acth Syndrome Ectopic 45
Ectopic Acth Syndrome 43
Hyperadrenocorticism 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
cushing disease:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology10 DOID:12252
NCIt40 C2969
MeSH35 D003480
ICD9CM29 255.0
Orphanet49 96253
MESH via Orphanet36 D047748
ICD10 via Orphanet28 E24.0
UMLS via Orphanet63 C0221406
ICD1027 E24, E24.3

Related Diseases for Cushing's Syndrome

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Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1acth-independent macronodular adrenal hyperplasia30.6GNAS
2adrenocortical carcinoma30.5CYP11B1, POMC
3adrenal adenoma30.4HSD11B1, HSD11B2, SULT2A1, CRH, GIPR, POMC
4nelson syndrome30.4SST, POMC, CRH
5congenital adrenal hyperplasia30.3POMC, MC2R, CRH, CYP11B1
6adrenal gland hyperfunction30.3CRH, SST, GIPR, POMC
7zollinger-ellison syndrome30.3SST, CHGA
8hypogonadism30.3CRH, POMC, LHCGR
9adrenal carcinoma30.3POMC
10lung cancer30.3POMC, CHGA, SST, SYP
11adenocarcinoma30.2SYP, CHGA, HSD11B1, HSD11B2, SST
12hyperaldosteronism30.2CYP11B1, POMC, HSD11B2
13multiple endocrine neoplasia 130.2GNAS, SST, CHGA
14hyperandrogenism30.1POMC, LHCGR, GNAS, SULT2A1, CRH
15obesity30.1GHSR, GIP, POMC, MC2R, HSD11B2, HSD11B1
16pituitary adenoma30.0CRH, SYP, GHSR, SST, CHGA, POMC
17pituitary-dependent cushing's disease30.0CRH, POMC
18pituitary carcinoma30.0POMC
19ganglioneuroma30.0POMC, CHGA, SYP
20gastrinoma30.0SYP, CHGA, SST
21neuroendocrine tumor30.0SYP, SST, CHGA
22conn's syndrome30.0POMC, CYP11B1
23leydig cell tumor30.0POMC, GNAS, LHCGR
24thyroid cancer30.0GNAS, CHGA, SST
25hyperprolactinemia29.9CRH, GNAS, SST, POMC
26hypothyroidism29.9GNAS, POMC, GHSR
27pheochromocytoma29.9SST, CHGA, SYP, POMC, GNAS, CRH
28hypoglycemia29.9CHGA, POMC, GIP, CRH, SST
29acromegaly29.9AIP, GNAS, HSD11B1, HSD11B2, POMC, SST
30adrenal cortical adenoma29.8CRH, NR2F1, SYP, CHGA, GIPR, POMC
31adenoma29.8NR2F1, CRH, SYP, GHSR, SST, CHGA
32small cell carcinoma10.5
33primary pigmented nodular adrenocortical disease10.4
34cushing syndrome due to ectopic acth secretion10.4
35familial glucocorticoid deficiency10.3
36olfactory neuroblastoma10.3
37cervicitis10.3
38pancreatitis10.3
39small cell carcinoma of the bladder10.3
40thymic neuroendocrine carcinoma10.3
41pigmented nodular adrenocortical disease, primary, 410.2
42multiple endocrine neoplasia10.2
43large cell neuroendocrine carcinoma10.2
44nocardiosis10.2
45lymphangitis10.2
46clear cell sarcoma10.2
47hypokalemia10.2
48gastric adenocarcinoma10.2
49hepatoblastoma10.2
50sarcoma10.2

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms for Cushing's Syndrome

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Symptoms:

 49 (show all 40)
  • round face
  • thin skin
  • cortico-adrenal hyperplasia/hypersecretion
  • pituitary/hypophyseal neoplasm/tumor/carcinoma/cancer
  • truncal obesity
  • abnormal fat distribution/lipodystrophy
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • cushingoid morphotype
  • acne/acnea
  • hirsutism/hypertrichosis/increased body hair
  • chronic arterial hypertension
  • bruisability
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • sterility/hypofertility
  • diabetes mellitus
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • mutiple fractures/bone fragility
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hypokalemia
  • asthenia/fatigue/weakness
  • cataract/lens opacification
  • visual loss/blindness/amblyopia
  • mild visual loss/impaired visual acuity
  • chronic skin infection/ulcerations/ulcers/cancrum
  • diffuse/generalised skin hyperpigmentation/melanoderma
  • telangiectasiae of the skin
  • onyxis/paronyxis/ungual inflammation
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • acute abdominal pain/colic
  • cardiomyopathy/hypertrophic/dilated
  • venous thrombosis/phlebitis/thrombophlebitis
  • precocious menopause/secondary amenorrhea
  • facial pain/cephalalgia/migraine
  • sleep and vigilance disorders
  • obnubilation/coma/lethargia/desorientation
  • psychosis/schizophrenia/maniac disorder
  • myopathy
  • osteonecrosis/bone infarction

HPO human phenotypes related to Cushing's Syndrome:

(show all 42)
id Description Frequency HPO Source Accession
1 round face hallmark (90%) HP:0000311
2 thin skin hallmark (90%) HP:0000963
3 hypercortisolism hallmark (90%) HP:0001578
4 truncal obesity hallmark (90%) HP:0001956
5 abnormality of adipose tissue hallmark (90%) HP:0009124
6 erectile abnormalities hallmark (90%) HP:0100639
7 neoplasm of the endocrine system hallmark (90%) HP:0100568
8 decreased fertility typical (50%) HP:0000144
9 nephrolithiasis typical (50%) HP:0000787
10 diabetes mellitus typical (50%) HP:0000819
11 hypertension typical (50%) HP:0000822
12 bruising susceptibility typical (50%) HP:0000978
13 hypertrichosis typical (50%) HP:0000998
14 acne typical (50%) HP:0001061
15 striae distensae typical (50%) HP:0001065
16 muscle weakness typical (50%) HP:0001324
17 recurrent fractures typical (50%) HP:0002757
18 hypokalemia typical (50%) HP:0002900
19 reduced bone mineral density typical (50%) HP:0004349
20 abnormality of immune system physiology typical (50%) HP:0010978
21 cataract occasional (7.5%) HP:0000518
22 secondary amenorrhea occasional (7.5%) HP:0000869
23 hypercortisolism occasional (7.5%) HP:0001578
24 hypertrophic cardiomyopathy occasional (7.5%) HP:0001639
25 abdominal pain occasional (7.5%) HP:0002027
26 sleep disturbance occasional (7.5%) HP:0002360
27 hypercalcemia occasional (7.5%) HP:0003072
28 abnormality of lipid metabolism occasional (7.5%) HP:0003119
29 myopathy occasional (7.5%) HP:0003198
30 hypernatremia occasional (7.5%) HP:0003228
31 abnormality of the gastric mucosa occasional (7.5%) HP:0004295
32 reduced consciousness/confusion occasional (7.5%) HP:0004372
33 aseptic necrosis occasional (7.5%) HP:0010885
34 abnormal renal physiology occasional (7.5%) HP:0012211
35 teleangiectasia of the skin occasional (7.5%) HP:0100585
36 neoplasm of the adrenal gland occasional (7.5%) HP:0100631
37 visual impairment occasional (7.5%) HP:0000505
38 paronychia occasional (7.5%) HP:0001818
39 migraine occasional (7.5%) HP:0002076
40 thrombophlebitis occasional (7.5%) HP:0004418
41 generalized hyperpigmentation occasional (7.5%) HP:0007440
42 skin ulcer occasional (7.5%) HP:0200042

Drugs & Therapeutics for Cushing's Syndrome

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Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cushing's Syndrome

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Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome24

Anatomical Context for Cushing's Syndrome

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MalaCards organs/tissues related to Cushing's Syndrome:

33
Pituitary, Adrenal gland, Skin, Bone, Testes, Cortex, Adrenal cortex, Kidney, Thyroid, Lung, Heart, Liver, Ovary, Prostate, Thymus, Brain, Pancreas, Pancreatic islet, Eye, Skeletal muscle, Colon, Adipocyte, Testis, Cervix, Endothelial, Hypothalamus

Animal Models for Cushing's Syndrome or affiliated genes

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Publications for Cushing's Syndrome

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Articles related to Cushing's Syndrome:

(show top 50)    (show all 920)
idTitleAuthorsYear
1
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. (24571724)
2014
2
Metachronous bilateral adrenocortical functional adenomas causing adrenocorticotropic hormone-independent Cushing's syndrome. (25197412)
2014
3
Screening for Cushing's syndrome: new immunoassays require adequate normative data. (23417245)
2013
4
Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome. (24083069)
2013
5
Hypercoagulable state in Cushing's syndrome is reversible following remission. (22724622)
2013
6
Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy. (22767639)
2012
7
Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. (22190002)
2012
8
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
9
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
10
Effect of Cushing's syndrome - Endogenous hypercortisolemia on cardiovascular autonomic functions. (21177144)
2011
11
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
12
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
13
Bone turnover in patients with endogenous Cushing's syndrome before and after successful treatment. (19513576)
2010
14
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
15
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
16
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. (20829630)
2010
17
Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone]. (19419710)
2009
18
Cushing's Syndrome: An Unusual Presentation of Olfactory Neuroblastoma. (18592016)
2008
19
Iatrogenic Cushing's syndrome and secondary adrenal insufficiency after a single intra-articular administration of triamcinolone acetonide in HIV-infected patients treated with ritonavir. (18827959)
2008
20
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17223996)
2007
21
Predicting the development of Cushing's syndrome in medullary thyroid cancer: utility of proopiomelanocortin messenger ribonucleic acid in situ hybridization. (17696832)
2007
22
Cushing's syndrome and adrenocortical insufficiency caused by topical steroids: misuse or abuse? (18183788)
2007
23
Role for laparoscopic adrenalectomy in patients with Cushing's syndrome. (18209873)
2007
24
Pharmacological management of Cushing's syndrome: an update. (18209872)
2007
25
Cushing's Syndrome: important issues in diagnosis and management. (16868050)
2006
26
Spindle cell pancreatic endocrine tumor associated with Cushing's syndrome. (16199900)
2005
27
18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography imaging of thymic carcinoid tumor presenting with recurrent Cushing's syndrome. (15817906)
2005
28
Cushing's syndrome with mediastinal lipomatosis. (15322612)
2004
29
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome. (14606715)
2003
30
Meningioma presenting with Cushing's syndrome: an unusual clinical presentation. (12509860)
2003
31
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia. (12744099)
2003
32
Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome? (14669823)
2003
33
A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of Cushing's syndrome: a comparison with the standard high-dose dexamethasone suppression test. (12523812)
2002
34
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. (11273885)
2001
35
Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. (11701732)
2001
36
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
37
Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH. (11248744)
2001
38
The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies. (11004721)
2000
39
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
40
Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. (9013748)
1996
41
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
42
A case of splenic artery aneurysm with Cushing's syndrome. (8818750)
1996
43
Psychiatric aspects of Cushing's syndrome. (8759496)
1996
44
Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: pituitary-adrenocortical function and immunohistochemistry. (8774967)
1995
45
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
46
Cushing's syndrome associated with lung tumors. (1313485)
1992
47
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
48
Primary bilateral adrenocortical causes of Cushing's syndrome. (1745978)
1991
49
The corticotropin-releasing factor test in the differential diagnosis of Cushing's syndrome: a comparison with the lysine-vasopressin test. (2239082)
1990
50
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970

Variations for Cushing's Syndrome

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Clinvar genetic disease variations for Cushing's Syndrome:

7
id Gene Variation Type Significance SNP ID Assembly Location
1GNAI2NM_002070.3(GNAI2): c.535C> G (p.Arg179Gly)single nucleotide variantPathogenicrs137853226GRCh37Chr 3, 50293694: 50293694
2GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
3GNASNM_001077488.2(GNAS): c.684G> C (p.Gln228His)single nucleotide variantPathogenicrs137854533GRCh37Chr 20, 57484597: 57484597
4AIPNM_003977.2(AIP): c.911G> A (p.Arg304Gln)single nucleotide variantPathogenicrs104894190GRCh37Chr 11, 67258382: 67258382

Cosmic variations for Cushing's Syndrome:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
117661CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
21423013CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
35692CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
496539CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
55664CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
685770CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
75667CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
813154CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
912639CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1029397CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1129399CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
125663CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1313153CTNNB1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1427889GNASadrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1527887GNASpituitary,NS,adenoma,ACTH3
1644915TP53adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1743678TP53adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
1822589MEN1pituitary,NS,adenoma,ACTH3
1923025MEN1adrenal gland,adrenal gland,adrenal cortical adenoma,NS3
20303944PIK3CApituitary,NS,adenoma,ACTH3
2128544PIK3CApituitary,NS,adenoma,ACTH3
22584NRASadrenal gland,adrenal gland,adrenal cortical adenoma,NS3
23482HRASpituitary,NS,adenoma,ACTH3

Expression for genes affiliated with Cushing's Syndrome

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Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

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Pathways related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CRH, POMC
2
Show member pathways
9.9GNAI2, POMC, GNAS
39.9GNAS, CRH, GNAI2
4
Show member pathways
9.8GNAS, GNAI2, SST
59.8NR2F1, AIP
69.7CRH, CHGA, MC2R
7
Show member pathways
9.6POMC, GNAI2, GNAS, LHCGR
8
Show member pathways
9.6CYP11B1, HSD11B1, POMC
9
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.5SULT2A1, CYP11B1
109.4MC2R, GNAS, AVPR2
11
Show member pathways
9.1GNAS, GNAI2, POMC, GIPR, GIP, CRH
12
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.0HSD11B2, HSD11B1, CYP11B1
138.6GNAS, GNAI2, SULT2A1, POMC, CRH, CYP11B1
14
Show member pathways
Peptide GPCRs38
8.5AVPR1B, LHCGR, GNAI2, MC2R, GHSR, AVPR2
158.0POMC, GIPR, CRH, GIP, MC2R, GNAI2
16
Show member pathways
7.0GNAI2, AVPR1B, AVPR2, CRH, GHSR, SST
17
Show member pathways
7.0AVPR2, GNAI2, CRH, GHSR, SST, GIP

Compounds for genes affiliated with Cushing's Syndrome

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Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 165)
idCompoundScoreTop Affiliating Genes
1pitressin4510.1SST, POMC, CRH
2hcrh459.9POMC, GHSR, CRH
3acth 1-24459.8CRH, MC2R, POMC
4111in-pentetreotide459.8SYP, SST, CHGA
5terlipressin45 1310.7SST, AVPR1B, AVPR2
6hexarelin45 3010.7GHSR, SST, POMC, CRH
711 deoxycortisol459.6POMC, CRH, CYP11B1
8ketoconazole45 30 26 1312.6SST, CRH, POMC, CYP11B1
9desmopressin45 61 30 1312.5AVPR1B, AVPR2, POMC, CRH
10isoproterenol45 1310.4CRH, LHCGR, GNAS, CHGA, SST
11gnrh459.4CRH, SST, LHCGR, CHGA, GNAS, POMC
12octreotide45 61 30 1312.3CHGA, CRH, GHSR, SST, POMC, GNAS
135-hydroxytryptamine459.3CHGA, SST, SYP, CRH, POMC
1411b-Hydroxyandrost-4-ene-3,17-dione269.3CYP11B1, HSD11B2, HSD11B1
15dehydroepiandrosterone sulfate459.2POMC, CRH, MC2R, SULT2A1
16cortisol30 2610.1CYP11B1, HSD11B1, HSD11B2, POMC
17spironolactone45 61 30 51 1313.1CYP11B1, HSD11B2, POMC, CRH
18metyrapone45 61 1311.1CRH, POMC, MC2R, HSD11B1, CYP11B1, SST
19betamethasone45 1310.1SYP, CRH, HSD11B2, POMC
20pge2459.0SST, POMC, HSD11B1, LHCGR, GNAS, CRH
21doca459.0HSD11B2, CYP11B1, POMC
22cortisone45 269.9CRH, POMC, CYP11B1, HSD11B1, HSD11B2
23guanine45 26 1310.8SULT2A1, SYP, GNAS, LHCGR, CHGA
2411beta-hydroxysteroid458.6HSD11B1, CYP11B1, MC2R, HSD11B2, POMC, CRH
25androstenedione45 269.5CYP11B1, CRH, POMC, HSD11B1, MC2R, HSD11B2
26histidine458.5CYP11B1, GNAS, GIP, CHGA, AVPR2, SYP
27norepinephrine45 26 1310.4GNAS, POMC, CHGA, SST, CRH, HSD11B2
28corticosterone45 61 2610.4HSD11B2, HSD11B1, LHCGR, CYP11B1, AVPR1B, POMC
29dhea458.3POMC, HSD11B1, CRH, MC2R, HSD11B2, SULT2A1
30glutamate458.3SST, SYP, CRH, GNAS, LHCGR, AVPR2
31dopamine45 30 26 1311.2GNAS, SULT2A1, CRH, POMC, SST, GHSR
32alanine458.1LHCGR, GNAS, HSD11B1, MC2R, POMC, AVPR2
33glucose458.0GNAS, HSD11B1, HSD11B2, POMC, GIP, SST
34cyclic amp45 269.0CHGA, MC2R, GIP, SYP, CRH, LHCGR
353beta-hydroxysteroid457.9CYP11B1, MC2R, POMC, LHCGR, SULT2A1, HSD11B2
36hydrocortisone45 3 61 1310.9SST, POMC, MC2R, HSD11B1, CYP11B1, CRH
37cholesterol45 30 26 1310.4CHGA, HSD11B1, LHCGR, CYP11B1, SULT2A1, MC2R
38ribonucleic acid457.3CRH, GHSR, CHGA, HSD11B2, CYP11B1, HSD11B1
39testosterone45 61 26 1310.1HSD11B1, SST, CRH, SYP, MC2R, POMC
40adenylate457.1CRH, AVPR2, LHCGR, POMC, GNAS, HSD11B2
41lipid456.9SULT2A1, HSD11B2, HSD11B1, GNAS, GHSR, GIP
42arginine456.8AVPR2, AVPR1B, CYP11B1, LHCGR, GNAS, HSD11B2
43estrogen456.7LHCGR, POMC, HSD11B2, SULT2A1, HSD11B1, CHGA
44calcium45 51 26 139.6CYP11B1, SYP, GHSR, GIP, MC2R, HSD11B2
45progesterone45 30 61 26 1310.6CYP11B1, LHCGR, GNAS, HSD11B1, HSD11B2, SYP
46estradiol45 26 138.6CRH, NR2F1, POMC, SYP, GHSR, CYP11B1
47dexamethasone45 51 30 139.6CYP11B1, CRH, SYP, HSD11B1, HSD11B2, SULT2A1
48forskolin45 51 138.1GNAS, HSD11B1, HSD11B2, SULT2A1, MC2R, POMC
49steroid455.9NR2F1, CYP11B1, GNAS, HSD11B1, HSD11B2, SULT2A1
50acth455.1HSD11B1, MC2R, POMC, GIPR, CHGA, SST

GO Terms for genes affiliated with Cushing's Syndrome

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Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.9GIP, POMC
2endosomeGO:00057689.4AVPR1B, AVPR2, LHCGR
3extracellular regionGO:00055768.8GNAS, POMC, GIP, CHGA, SST, CRH
4plasma membraneGO:00058867.8GIPR, MC2R, GNAI2, GNAS, LHCGR, AIP

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:000862810.2CRH, SST
2positive regulation of cAMP-mediated signalingGO:004395010.0GIP, GNAS, LHCGR
3positive regulation of cAMP biosynthetic processGO:00308199.9GNAS, MC2R, CRH
4response to amino acidGO:00432009.9SST, GIP
5response to nutrientGO:00075849.9SST, GIPR, GNAI2
6long-term synaptic potentiationGO:00602919.9CRH, GIP
7regulation of blood pressureGO:00082179.8CYP11B1, POMC, CHGA
8response to axon injuryGO:00486789.7GIP, GIPR
9activation of adenylate cyclase activityGO:00071909.5AVPR2, LHCGR, GNAS, GIPR
10steroid metabolic processGO:00082029.4SULT2A1, HSD11B1, CYP11B1
11response to foodGO:00320949.3GHSR, HSD11B2
12xenobiotic metabolic processGO:00068059.3AIP, CYP11B1, SULT2A1
13female pregnancyGO:00075659.2GNAS, HSD11B2, GIP, CRH
14glucocorticoid biosynthetic processGO:00067049.0CRH, HSD11B2, HSD11B1, CYP11B1
15G-protein coupled receptor signaling pathwayGO:00071869.0AVPR1B, LHCGR, GNAI2, MC2R, SST, GHSR
16signal transductionGO:00071659.0AIP, GNAI2, POMC, GIP, CRH, NR2F1
17response to drugGO:00424938.9CRH, SST, GIP, HSD11B2, GNAS

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:00170469.8GHSR, GIPR
2G-protein beta/gamma-subunit complex bindingGO:00316839.8GNAI2, GNAS
3vasopressin receptor activityGO:00050009.6AVPR1B, AVPR2
4hormone activityGO:00051799.5CRH, SST, GIP, POMC
511-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00038459.3HSD11B2, HSD11B1

Products for genes affiliated with Cushing's Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cushing's Syndrome

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet