MCID: CSH001
MIFTS: 65

Cushing's Syndrome malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Cushing's Syndrome

About this section

Aliases & Descriptions for Cushing's Syndrome:

Name: Cushing's Syndrome 11 48 49 38 13
Cushing Syndrome 11 48 50 39 68
Hypercortisolism 48 49 27 50
Cushing's Disease 27 13
Adrenal Hyperfunction Resulting from Pituitary Acth Excess 48
Ectopic Adrenocorticotropic Hormone Syndrome 48
Nodular Primary Adrenocortical Dysplasia 48
Adrenal Gland Hyperfunction 68
Adrenal Cushing's Syndrome 68
 
Adrenal Cortical Adenoma 68
Suprarenogenic Syndrome 11
Adrenal Cortex Adenoma 48
Acth Syndrome, Ectopic 68
Pituitary Basophilism 11
Acth Syndrome Ectopic 50
Ectopic Acth Syndrome 48
Hyperadrenocorticism 48

Classifications:



External Ids:

Disease Ontology11 DOID:12252
ICD1030 E24, E24.9, E24.3
ICD9CM32 255.0
MeSH39 D003480
NCIt45 C2969

Summaries for Cushing's Syndrome

About this section
NINDS:49 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards based summary: Cushing's Syndrome, also known as cushing syndrome, is related to pheochromocytoma and ectopic cushing syndrome, and has symptoms including cushingoid facies, cushingoid facies and agitation. An important gene associated with Cushing's Syndrome is POMC (Proopiomelanocortin), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Serotonin Receptor 4/6/7 and NR3C Signaling. The drugs fluorocortisol acetate and fludrocortisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and skin, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and no phenotypic analysis.

NIH Rare Diseases:48 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). it most commonly affects adults between age 20 and 50 years. signs and symptoms of cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. affected women may also experience irregular menstrual periods and increased growth of body and facial hair. this condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors. last updated: 11/28/2014

MedlinePlus:38 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Disease Ontology:11 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

Wikipedia:71 Cushing\'s syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol. Signs... more...

Related Diseases for Cushing's Syndrome

About this section

Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Macronodular Adrenal Hyperplasia

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1pheochromocytoma29.3CHGA, CRH, POMC, SST
2ectopic cushing syndrome12.3
3cushing syndrome due to macronodular adrenal hyperplasia11.9
4pituitary adenoma, acth-secreting11.8
5cushing syndrome, familial11.7
6acth-independent macronodular adrenal hyperplasia11.6
7pigmented nodular adrenocortical disease, primary, 411.6
8pigmented nodular adrenocortical disease, primary, 311.5
9pigmented nodular adrenocortical disease, primary, 111.5
10pigmented nodular adrenocortical disease, primary, 211.4
11acth-independent macronodular adrenal hyperplasia 211.4
12glucocorticoid resistance10.9
13mccune-albright syndrome, somatic, mosaic10.9
14primary pigmented nodular adrenocortical disease10.5
15nelson syndrome10.5
16burning mouth syndrome type 310.3POMC, SST
17renal hypoplasia, bilateral10.3POMC, SST
18water-clear cell adenoma10.3POMC, SST
19vaginal adenoma10.3POMC, SST
20african histoplasmosis10.3POMC, SST
21early-onset parkinson disease10.2CRH, POMC, SST
22keratosis10.2CRH, NR3C1, POMC
23secondary syphilis10.2CHGA, SST
24brain edema10.2CHGA, SST
25immune system organ benign neoplasm10.2CRH, POMC, SST
26hereditary multiple exostoses10.2CRH, NR3C1, POMC
27cleft lip palate-tetraphocomelia10.2CYP21A2, POMC
28grin2a-related speech disorders and epilepsy10.2GH1, GNAS
29uterine ligament cancer10.2GNAS, PRKAR1A, SST
30lichen disease10.2CRH, NR3C1, POMC
31endocrine organ benign neoplasm10.2CRH, POMC, SST
32distal monosomy 14q10.2CYP21A2, POMC
33extragonadal nonseminomatous germ cell tumor10.2POMC, SST
34macrocephaly, benign familial10.2GH1, POMC
35ataxia, spastic, 5, autosomal recessive10.2MC2R, POMC
36cerebral hemisphere lipoma10.2GH1, SST
37mitochondrial complex ii deficiency10.2CHGA, POMC, SST
38congenital tricuspid stenosis10.2GH1, POMC
39lymph node cancer10.2CRH, NR3C1
40intermittent squint10.2CRH, GH1, POMC
41bone dysplasia azouz type10.2CHGA, CRH, SST
42eccrine papillary adenocarcinoma10.2CHGA, POMC, SST
43non-syndromic x-linked intellectual disability10.1CHGA, POMC, SST
44hypogonadism cardiomyopathy10.1CRH, GH1, POMC
45malignant otitis externa10.1CRH, CYP21A2, POMC
46dyt1 early-onset isolated dystonia10.1CYP21A2, POMC
47pemphigus vegetans10.1GH1, SST
48nonparalytic poliomyelitis10.1CRH, NR3C1, POMC, SST
49loeffler endocarditis10.1CRH, CYP21A2, POMC
50capillary lymphangioma10.1CRH, GH1, POMC

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Symptoms & Phenotypes for Cushing's Syndrome

About this section

Human phenotypes related to Cushing's Syndrome:

 64 (show all 39)
id Description HPO Frequency HPO Source Accession
1 decreased fertility64 HP:0000144
2 round face64 HP:0000311
3 cataract64 HP:0000518
4 psychosis64 HP:0000709
5 depression64 HP:0000716
6 irritability64 HP:0000737
7 anxiety64 HP:0000739
8 nephrolithiasis64 HP:0000787
9 diabetes mellitus64 HP:0000819
10 hypertension64 HP:0000822
11 secondary amenorrhea64 HP:0000869
12 osteoporosis64 HP:0000939
13 thin skin64 HP:0000963
14 bruising susceptibility64 HP:0000978
15 purpura64 HP:0000979
16 acne64 HP:0001061
17 striae distensae64 HP:0001065
18 muscle weakness64 HP:0001324
19 growth delay64 HP:0001510
20 dilated cardiomyopathy64 HP:0001644
21 truncal obesity64 HP:0001956
22 abdominal pain64 HP:0002027
23 generalized hirsutism64 HP:0002230
24 sleep disturbance64 HP:0002360
25 recurrent fractures64 HP:0002757
26 hypokalemia64 HP:0002900
27 hyponatremia64 HP:0002902
28 hypercalcemia64 HP:0003072
29 increased circulating cortisol level64 HP:0003118
30 hypercholesterolemia64 HP:0003124
31 myopathy64 HP:0003198
32 abnormality of the gastric mucosa64 HP:0004295
33 reduced consciousness/confusion64 HP:0004372
34 abnormal subcutaneous fat tissue distribution64 HP:0007552
35 aseptic necrosis64 HP:0010885
36 fatigue64 HP:0012378
37 telangiectasia of the skin64 HP:0100585
38 neoplasm of the adrenal gland64 HP:0100631
39 erectile abnormalities64 HP:0100639

UMLS symptoms related to Cushing's Syndrome:


cushingoid facies, agitation

GenomeRNAi Phenotypes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.6GH1, HSD11B2, POMC

MGI Mouse Phenotypes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7CRH, GNAS, HSD11B2, NR3C1, POMC, SST
2MP:00053708.7CRH, GNAS, HSD11B1, NR3C1, POMC, PRKAR1A
3MP:00053677.8CHGA, CRH, GNAS, HSD11B2, NR3C1, POMC
4MP:00053757.4CRH, GNAS, HSD11B1, MC2R, NR3C1, POMC
5MP:00053867.4CRH, GNAS, HSD11B1, HSD11B2, MC2R, NR3C1
6MP:00036317.0CRH, GNAS, HSD11B1, MC2R, NR3C1, PDE11A
7MP:00053856.8CHGA, GNAS, HSD11B1, HSD11B2, MC2R, NR3C1
8MP:00053786.6CHGA, CRH, GNAS, HSD11B1, MC2R, NR3C1
9MP:00053796.6CHGA, CRH, GIPR, GNAS, HSD11B1, MC2R
10MP:00053766.0CHGA, CRH, GIPR, GNAS, HSD11B1, HSD11B2

Drugs & Therapeutics for Cushing's Syndrome

About this section

Drugs for Cushing's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 108)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Epinephrineapproved, vet_approvedPhase 4, Phase 3, Phase 298551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2
Mifepristoneapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 115584371-65-355245
Synonyms:
(11beta,17beta)-11-(4-(Dimethylamino)-phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
(11beta,17beta)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-prop-1-yn-1-ylestra-4,9-dien-3-one
(2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
(8S,11R,13S,14S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
11-(4-DIMETHYLAMINO-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodec ahydro-cyclopenta[a]phenanthren-3-one
11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on
11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on
11beta-(4-(N,N-Dimethylamino)phenyl)-17alpha-(prop-1-ynyl)-delta4,9-estradiene-17beta-ol-3-one
11beta-(4-Dimethyl-?amino)-?phenyl-17beta-hydroxy-17-(1-propynyl)-?estra-4,9-dien-3-one
11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
122742-25-0
17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one
404951-53-7
83203-42-3
84371-65-3
AC1L1IOO
AC1O62SB
Ambap84371-65-3
BIDD:PXR0123
BPBio1_000262
BRD-K37270826-001-04-5
BRN 5779404
BSPBio_000238
C-1073
C07652
C29H35NO2
CHEBI:50692
CHEMBL157
CHEMBL356066
CI-1073
CID55245
CID6445533
CPD000058481
Contragest Brand of Mifepristone
Corlux
D00585
D015735
DB00834
Dacinostat
Danco Brand of Mifepristone
EC-000.2469
EU-0100801
Exelgyn Brand of Mifepristone
FT-0082666
HMS1568L20
HMS2052L05
HMS2090L22
HSCI1_000369
HSDB 6841
I14-11726
LAQ-824
LS-192513
LS-64723
Lopac0_000801
M 8046
 
M8046_SIGMA
MLS000069785
MLS001074115
Mifegyne
Mifeprex
Mifeprex (TN)
Mifepriston
Mifepristona
Mifepristona [Spanish]
Mifepristone (USAN/INN)
Mifepristone Contragest Brand
Mifepristone Danco Brand
Mifepristone Exelgyn Brand
Mifepristone [USAN:INN:BAN]
Mifepristonum
Mifepristonum [Latin]
Mifépristone
MolPort-003-849-222
NCGC00025179-05
NCGC00025179-08
NCGC00179632-01
NVP-LAQ 824
NVP-LAQ824
NVP-LAQ824, Dacinostat, LAQ824
Pictovir
Pictovir (TM)
Prestwick0_000299
Prestwick1_000299
Prestwick2_000299
Prestwick3_000299
Prestwick_570
R 38486
R-38486
R38486
RU 38486
RU 486
RU 486-6
RU-38486
RU-486
RU-486, MIFEPRISTONE
RU-486, RU-38486, Mifegyne, Mifeprex, Mifepristone
RU38486
RU486
S1095_Selleck
S1611_Selleck
SAM001246881
SMR000058481
SPBio_002457
Spectrum5_002045
TL8005515
UNII-320T6RNW1F
UNII-V10P524501
VGX-410
VGX-410C
VX-410
ZINC03831128
ZK 98296
ZK-98296
ZK98296
mifepristone
nchembio.313-comp12
3
SomatostatinapprovedPhase 4, Phase 223738916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
4Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113168
5RacepinephrinePhase 4, Phase 3, Phase 2985
6HormonesPhase 4, Phase 2, Phase 3, Phase 114415
7Epinephryl boratePhase 4, Phase 3, Phase 2985
8Hormone AntagonistsPhase 4, Phase 2, Phase 3, Phase 113180
9glucocorticoidsPhase 4, Phase 2, Phase 3, Phase 15103
10Contraceptive AgentsPhase 4, Phase 3, Phase 2, Phase 11967
11Luteolytic AgentsPhase 4, Phase 3, Phase 2, Phase 1306
12Contraceptives, OralPhase 4, Phase 3, Phase 2, Phase 11327
13Contraceptives, PostcoitalPhase 4, Phase 3, Phase 2, Phase 1175
14
LactitolPhase 4336585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
15
MetforminapprovedPhase 2, Phase 31803657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
16
Hydrocortisoneapproved, vet_approvedPhase 3, Phase 2, Phase 166750-23-75754, 657311
Synonyms:
(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
11-Hydrocortisone
11-beta-Hydrocortisone
11-beta-Hydroxycortisone
11a-Hydroxycorticosterone
11alpha-Hydroxycorticosterone
11b,17,21-Trihydroxyprogesterone
11b-Hydrocortisone
11b-Hydroxycortisone
11beta,17,21-Trihydroxyprogesterone
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
11beta-Hydrocortisone
11beta-Hydroxycortisone
11beta-hydrocortisone
11β-hydrocortisone
17-Hydroxycorticosterone
17a-Hydroxycorticosterone
17alpha-Hydroxycorticosterone
2v95
4-Pregnen-11beta,17alpha,21-triol-3,20-dione
4-Pregnene-11alpha,21-triol 3,20-dione
4-Pregnene-11b,17a,21-triol-3,20-dione
50-23-7
8056-08-4
80562-38-5
8063-42-1
AC-12902
AC1L1L2B
ACETASOL HC
ACETIC ACID W/ HYDROCORTISONE
AI3-25006
AKOS001582651
Acticort
Acticort (TN)
Aeroseb HC
Aeroseb-HC
Ala-Cort
Ala-Scalp
Alacort
Algicirtis
Alphaderm
Amberin
Anflam
Anti-inflammatory hormone
Anucort
Anucort-HC
Anusol HC
Anusol HC (TN)
Aquacort
Aquanil HC
B48448A1-24BA-47CA-8D9E-43E5BC949386
BPBio1_000544
BRD-K93568044-001-03-1
BSPBio_000494
Balneol-hc
Barseb HC
Basan-Corti
Beta-hc
Bio-0648
C00735
C21H30O5
CCRIS 5854
CHEBI:17650
CHEMBL389621
CID5754
COR-OTICIN
CPD000653523
CaldeCORT Spray
Cetacort
Chronocort
Clear aid
Cleiton
Cobadex
Colocort
Colocort (TN)
Compound F
Compound F (kendall)
Cor-Tar-Quin
Corhydron
Cort-Dome
Cort-Quin
Cortanal
Cortef
Cortef (TN)
Cortenema
Cortesal
Corticreme
Cortifair
Cortifan
Cortifoam
Cortiment
Cortisol
Cortisol alcohol
Cortisol, Hydrocortisone
Cortisolonum
Cortisporin
Cortisporin Otico
Cortispray
Cortizol
Cortolotion
Cortonema
Cortoxide
Cortril
Cremesone
Cremicort-H
Cutisol
Cyclodextrin-encapsulated hydrocortisone
D00088
DB00741
DB07886
Delacort
Derm-Aid
Dermacort
Dermaspray
Dermil
Dermocortal
Dermolate
Dihydrocostisone
Dioderm
Dome-cort
Domolene-HC
Drotic
DuoCort
EINECS 200-020-1
EU-0100594
Ef corlin
Efcorbin
Efcortelan
Efcortelin
Eldecort
Eldercort
Epicort
Epicortisol
Epiderm H
Esiderm H
Evacort
Ficortril
Fiocortril
Flexicort
Foille Insetti
Genacort
Genacort (lotion)
Glycort
Gyno-Cortisone
H 4001
H-Cort
H0135_SIGMA
H0396_SIGMA
H0888_SIGMA
H3160_SIGMA
H4001_SIGMA
H6909_SIGMA
HC
HC #1
 
HC #4
HC (HYDROCORTISONE)
HMS1569I16
HMS2090M04
HSDB 3339
HYDROCORTISONE AND ACETIC ACID
HYDROCORTISONE IN ABSORBASE
Heb Cort
Heb-Cort
Hi-cor
Hidalone
Hidro-Colisona
Hidrocortisona
Hidrocortisona [INN-Spanish]
Hycort
Hycortol
Hycortole
Hydracort
Hydrasson
Hydro-Adreson
Hydro-Colisona
Hydro-RX
Hydro-colisona
Hydrocort
Hydrocortal
Hydrocorticosterone
Hydrocortisone
Hydrocortisone (JP15/USP/INN)
Hydrocortisone Acetate
Hydrocortisone Base
Hydrocortisone Butyrate
Hydrocortisone Sodium Phosphate
Hydrocortisone Valerate
Hydrocortisone [INN:BAN:JAN]
Hydrocortisone alcohol
Hydrocortisone base
Hydrocortisone free alcohol
Hydrocortisone solution
Hydrocortisone-Water Soluble
Hydrocortisonum
Hydrocortisonum [INN-Latin]
Hydrocortistab
Hydrocortisyl
Hydrocortone
Hydroskin
Hydroxycortisone
Hysone
Hytisone
Hytone
Hytone (TN)
Hytone lotion
Idrocortisone
Idrocortisone [DCIT]
Incortin-H
Incortin-hydrogen
Kendall'S compound F
Kendall's compound F
Komed HC
Kyypakkaus
LMST02030001
LS-7439
Lacticare HC
Lacticare-HC
Lactisona
Lopac0_000594
Lubricort
MLS000069609
MLS001148103
MLS002207135
MLS002222189
Maintasone
Medicort
Meusicort
Mildison
Milliderm
MolPort-001-794-637
NCGC00022848-06
NCGC00022848-07
NCGC00022848-09
NCGC00022848-12
NCI60_000118
NSC 10483
NSC-10483
NSC10483
Neo-Cort-Dome
Neo-Cortef
Neosporin-H Ear
Nogenic HC
Nutracort
Nystaform-HC
ORLEX HC
Optef
Otalgine
Otic-Neo-Cort-Dome
Otobiotic
Otocort
Otosone-F
Pediotic Suspension
Penecort
Permicort
Polcort H
Preparation H Hydrocortisone Cream
Prepcort
Prestwick0_000447
Prestwick1_000447
Prestwick2_000447
Prestwick3_000447
Prestwick_265
Prevex HC
Proctocort
Proctofoam
Proctozone HC
Protocort
Racet
Rectasol-HC
Rectoid
Reichstein'S substance M
Reichstein's substance M
Remederm HC
S1696_Selleck
SAM002264617
SMP1_000156
SMR000059022
SMR000653523
SPBio_002433
Sanatison
Scalp-Cort
Scalpicin Capilar
Schericur
Scheroson F
Sigmacort
Signef
Stie-cort
Stiefcorcil
Synacort
Systral Hydrocort
Tarcortin
Texacort
Texacort lotion 25
Timocort
Topicort
Transderma H
Traumaide
UNII-WI4X0X7BPJ
UPCMLD-DP133
UPCMLD-DP133:001
Uniderm
Vioform-Hydrocortisone
VoSol HC
Vytone
Zenoxone
[3H]cortisol
component of Lubricort
component of Neo-Cort-Dome
component of Otalgine
hydrocortisone
17
Dexamethasoneapproved, investigational, vet_approvedPhase 3217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
18
MetyraponeapprovedPhase 31254-36-44174
Synonyms:
1,2-Di-3-pyridyl-2-methyl-1-propanone
2-Methyl-1,2-bis(3-pyridyl)-1-propanone
2-Methyl-1,2-di-3-pyridinyl-1-propanone
2-Methyl-1,2-di-3-pyridyl-1-propanone
2-methyl-1,2-dipyridin-3-yl-propan-1-one
2-methyl-1,2-dipyridin-3-ylpropan-1-one
37245-80-0
4885, SU
54-36-4
856525_ALDRICH
AB00513955
AC1L1HKV
AC1Q1LHX
Alliance Brand of Metyrapone
BIDD:PXR0082
BPBio1_000824
BRD-K46862739-001-03-6
BSPBio_000748
C07205
C14H14N2O
CAS-54-36-4
CHEBI:44241
CHEMBL934
CID4174
CPD-7023
CPD000059134
D00410
D008797
DB01011
EINECS 200-206-2
EU-0009322
HMS1570F10
HMS2094I07
HSDB 2500
LS-123097
METOPIRONE (TN)
MLS001066377
MLS001335881
MLS001335882
MYT
 
Mepyrapone
Metapirone
Metapyron
Methapyrapone
Methbipyranone
Methopirapone
Methopyrapone
Methopyrinine
Methopyrone
Metirapona
Metirapona [INN-Spanish]
Metopiron
Metopirone
Metopyrone
Metroprione
Metyrapon
Metyrapone
Metyrapone (JP15/USP/INN)
Metyrapone Alliance Brand
Metyrapone Novartis Brand
Metyrapone [USAN:INN:BAN:JAN]
Metyraponum
Metyraponum [INN-Latin]
MolPort-001-794-644
NCGC00016242-01
NCGC00161837-01
NSC 25265
NSC25265
Novartis Brand of Metyrapone
Prestwick0_000904
Prestwick1_000904
Prestwick2_000904
Prestwick3_000904
SAM002297829
SMR000059134
SPBio_002947
ST51006925
Su 4885
Su-4885
UNII-ZS9KD92H6V
ZINC00001728
metyrapone
19
Lidocaineapproved, vet_approvedPhase 2, Phase 31317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
20AnestheticsPhase 2, Phase 39596
21Hypoglycemic AgentsPhase 2, Phase 35896
22Adrenergic beta-AgonistsPhase 2, Phase 31714
23MydriaticsPhase 2, Phase 3811
24Neurotransmitter AgentsPhase 2, Phase 318340
25Adrenergic alpha-AgonistsPhase 2, Phase 31734
26Adrenergic AgonistsPhase 2, Phase 33027
27Peripheral Nervous System AgentsPhase 3, Phase 223689
28Anti-Asthmatic AgentsPhase 2, Phase 33488
29Bronchodilator AgentsPhase 2, Phase 32965
30Adrenergic AgentsPhase 2, Phase 35352
31Hydrocortisone acetatePhase 3, Phase 2, Phase 1667
32Hydrocortisone 17-butyrate 21-propionatePhase 3, Phase 2, Phase 1667
33AndrogensPhase 2, Phase 31321
34Cortisol succinatePhase 3, Phase 2, Phase 1667
35beta-endorphinPhase 3, Phase 2140
36Adrenocorticotropic HormonePhase 3, Phase 2164
37Melanocyte-Stimulating HormonesPhase 3, Phase 2139
38Antirheumatic AgentsPhase 310956
39Respiratory System AgentsPhase 2, Phase 34997
40Anti-Inflammatory AgentsPhase 3, Phase 210729
41Vasoconstrictor AgentsPhase 2, Phase 32122
42Interleukin 1 Receptor Antagonist ProteinPhase 399
43Autonomic AgentsPhase 3, Phase 210150
44BB 1101Phase 32171
45Antineoplastic Agents, HormonalPhase 3, Phase 25592
46AntiemeticsPhase 3, Phase 24022
47
protease inhibitorsPhase 35471
Synonyms:
 
protease inhibitors
48Dexamethasone 21-phosphatePhase 32171
49AntimetabolitesPhase 312054
50Dexamethasone acetatePhase 321711177-87-3

Interventional clinical trials:

(show top 50)    (show all 75)
idNameStatusNCT IDPhase
1Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal HypercortisolismCompletedNCT01990560Phase 4
2Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic AdrenalectomyCompletedNCT01959711Phase 4
3Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study.RecruitingNCT01794793Phase 4
4Prevention of Metabolic Complications of Glucocorticoid ExcessUnknown statusNCT01319994Phase 2, Phase 3
5Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's SyndromeCompletedNCT01371565Phase 3
6An Extension Study of CORLUX in the Treatment of Endogenous Cushing's SyndromeCompletedNCT00936741Phase 3
7A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's SyndromeCompletedNCT00569582Phase 3
8Effects of IL-1 Beta on the HPA-axis in Obese PersonsCompletedNCT02227420Phase 3
9Treatment for Endogenous Cushing's SyndromeRecruitingNCT01838551Phase 3
10Effects of Metyrapone in Patients With Endogenous Cushing's SyndromeRecruitingNCT02297945Phase 3
11Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?RecruitingNCT01504555Phase 3
12Dynamic Hormone Diagnostics in Endocrine DiseaseNot yet recruitingNCT02934399Phase 2, Phase 3
13Mifepristone in Children With Refractory Cushing's DiseaseWithdrawnNCT01925092Phase 3
14A Study to Assess SOM230 in Patients With Pituitary Cushing's DiseaseCompletedNCT00088608Phase 2
15SOM230 Ectopic ACTH-producing TumorsRecruitingNCT02780882Phase 2
16Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing SyndromeRecruitingNCT02019706Phase 2
17Study of Efficacy and Safety of Osilodrostat in Cushing's SyndromeRecruitingNCT02468193Phase 2
18New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing SyndromeRecruitingNCT00001849Phase 1, Phase 2
19Study to Evaluate CORT125134 in Patients With Cushing's SyndromeRecruitingNCT02804750Phase 2
20A Study of ATR-101 for the Treatment of Endogenous Cushing's SyndromeRecruitingNCT03053271Phase 2
21Efficacy of Mifepristone in Males With Type 2 Diabetes MellitusRecruitingNCT03052400Phase 2
22Mifepristone for Metabolic SyndromeRecruitingNCT01419535Phase 1, Phase 2
23Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical CarcinomaActive, not recruitingNCT03145285Phase 2
24Study of Adrenalectomy Versus Observation for Subclinical HypercortisolismActive, not recruitingNCT02001051Phase 2
25Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrsNot yet recruitingNCT02611258Phase 2
26Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 InhibitionNot yet recruitingNCT03111810Phase 2
27Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) SecretionTerminatedNCT00422201Phase 2
28Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine OriginTerminatedNCT00958841Phase 2
29Pasireotide Therapy in Patients With Nelson's SyndromeTerminatedNCT01617733Phase 2
30Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's SyndromeUnknown statusNCT00682084
31Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's SyndromeUnknown statusNCT00004343
32Study of Depression, Peptides, and Steroids in Cushing's SyndromeUnknown statusNCT00004334
33Anesthesia Management of Retroperitoneal AdrenalectomiesUnknown statusNCT00894335
34Long Term Post Operative Follow-Up of Cushing SyndromeCompletedNCT00029952
35Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing SyndromeCompletedNCT00001453
36Hippocampal Complex Volume and Memory Dysfunction in Cushing's SyndromeCompletedNCT00004326
37Pattern of Gene Expression in Adipose Tissue From Patients With Cushing SyndromeCompletedNCT01688349
38In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in ManCompletedNCT02889224
39Study of Cushing's Syndrome Not Related to ACTH ProductionCompletedNCT00006278
40Cognition, Steroids, and Imaging in Cushings DiseaseCompletedNCT00081341
41Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal InsufficiencyCompletedNCT00001180
42The Factors Associated With the Recurrence in Patients With Cushing DiseaseCompletedNCT02233335
43Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative StudyCompletedNCT02618694
44Heart Disease Risk Factors in Major DepressionCompletedNCT00001969
45Metabolic Effects of Acute Cortisol Withdrawal in Adrenal FailureCompletedNCT00442390
46To Study Polycystic Ovary Syndrome in Taiwanese WomenCompletedNCT01256944
47Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary HyperparathyroidismCompletedNCT03027349
48Adolescence, Puberty, and Emotion RegulationCompletedNCT00016731
49Dynamics of Leptin and Endocrine FunctionCompletedNCT00001543
50Study of Adrenal Gland TumorsRecruitingNCT00005927

Search NIH Clinical Center for Cushing's Syndrome

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: cushing syndrome

Genetic Tests for Cushing's Syndrome

About this section

Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome27
2 Hypercortisolism27

Anatomical Context for Cushing's Syndrome

About this section

MalaCards organs/tissues related to Cushing's Syndrome:

36
Pituitary, Adrenal gland, Skin, Testes, Cortex, Adrenal cortex, Bone

Publications for Cushing's Syndrome

About this section

Articles related to Cushing's Syndrome:

(show top 50)    (show all 1037)
idTitleAuthorsYear
1
Which type 2 diabetes mellitus patients should be screened for subclinical Cushing's syndrome? (28500825)
2017
2
Glucose metabolism abnormalities in Cushing's syndrome: from molecular basis to clinical management. (28368467)
2017
3
Case of diabetic ketoacidosis as an initial presentation of Cushing's syndrome. (28458895)
2017
4
Exogenous Cushing's syndrome due to a Chinese herbalist's prescription of ointment containing dexamethasone. (28432185)
2017
5
Extended low-dose dexamethasone suppression test for diagnosis of atypical Cushing's syndrome in dogs. (28371654)
2017
6
Diagnosis and Differential Diagnosis of Cushing's Syndrome. (28402781)
2017
7
Cushing's syndrome managed by endoscopic ultrasound-guided radiofrequency ablation of adrenal gland adenoma. (28068682)
2017
8
Characteristics and Mortality of Pneumocystis Pneumonia in Patients With Cushing's Syndrome: A Plea for Timely Initiation of Chemoprophylaxis. (28480275)
2017
9
Increased prevalence of obstructive sleep apnea in patients with Cushing's syndrome compared with weight- and age-matched controls. (27932409)
2017
10
Psychiatric Symptoms in Patients with Cushing's Syndrome: Prevalence, Diagnosis and Management. (28393326)
2017
11
Persistence of myopathy in Cushing's syndrome: evaluation of the German Cushing's Registry. (28325824)
2017
12
Ritonavir and Topical Ocular Corticosteroid Induced Cushing's Syndrome in an Adolescent with HIV-1 Infection. (28060049)
2017
13
Acute mesenteric ischemia and hepatic infarction after treatment of ectopic Cushing's syndrome. (28480039)
2017
14
Bronchopulmonary carcinoid with a single lymph node metastasis causing ectopic Cushing's syndrome. (28449502)
2017
15
Cushing's syndrome: a practical approach to diagnosis and differential diagnoses. (28069628)
2017
16
Portal Vein Thrombosis in the Setting of Newly Diagnosed Cushing's Syndrome. (28491882)
2017
17
Cushing's Syndrome and Treatment-Resistant Depression. (28515565)
2017
18
Cushing's syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma. (28328532)
2017
19
Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels. (27932530)
2017
20
Clobetasol, Acitretin, and Cushing's Syndrome. (28297151)
2017
21
Body composition in pituitary, adrenal and iatrogenic Cushing's syndrome and effects of DHEAS levels. (27696526)
2017
22
Cushing's Syndrome, Cortisol, and Cognitive Competency: A Case Report. (28512418)
2017
23
Diagnostic tests for Cushing's syndrome differ from published guidelines: data from ERCUSYN. (28377460)
2017
24
Growth hormone deficiency in treated acromegaly and active Cushing's syndrome. (28477735)
2017
25
Zinc alpha-2 glycoprotein is overproduced in Cushing's syndrome. (28440767)
2017
26
White matter involvement on DTI-MRI in Cushing's syndrome relates to mood disturbances and processing speed: a case-control study. (28332051)
2017
27
A Rare Case of Subclinical Primary Aldosteronism and Subclinical Cushing's Syndrome without Cardiovascular Complications. (27050894)
2016
28
Cushing's Syndrome And Steroid Dementia. (27515536)
2016
29
E2F1-mediated human POMC expression in ectopic Cushing's syndrome. (27935805)
2016
30
Vascular health in patients in remission of Cushing's syndrome is comparable to that in BMI-matched controls. (27552540)
2016
31
Cushing's syndrome due to ectopic ACTH secretion. (27387249)
2016
32
Brain metabolite abnormalities in ventromedial prefrontal cortex are related to duration of hypercortisolism and anxiety in patients with Cushing's syndrome. (27103571)
2016
33
Mifepristone Improves Octreotide Efficacy in Resistant Ectopic Cushing's Syndrome. (26989527)
2016
34
Cushing's syndrome. (27551694)
2016
35
Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy". (27901643)
2016
36
MECHANISMS IN ENDOCRINOLOGY: Tissue-Specific Activation of Cortisol in Cushing's Syndrome. (26957494)
2016
37
Role of "old" pharmacological agents in the treatment of Cushing's syndrome. (27086313)
2016
38
Adrenalectomy for Cushing's syndrome: do's and don'ts. (27928434)
2016
39
Complications of Cushing's syndrome: state of the art. (27177728)
2016
40
Cushing's Syndrome From Pituitary Microadenoma and Pulmonary Nodules. (26906124)
2016
41
Markers of atherosclerosis in patients with Cushing's syndrome: a meta-analysis of literature studies. (27763781)
2016
42
Incompatibility between fasting and postprandial plasma glucose in patients with Cushing's syndrome. (27498594)
2016
43
Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome. (27766686)
2016
44
Skin manifestations of Cushing's syndrome. (27943005)
2016
45
Ketoconazole and endogenous Cushing's syndrome. Effective but tricky to use. (27152395)
2016
46
Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies. (27600150)
2016
47
Cushing's Syndrome: Screening and Diagnosis. (27160717)
2016
48
A probabilistic model for Cushing's syndrome screening in at-risk populations: a prospective multicenter study. (27490917)
2016
49
Cushing's Syndrome: Where and How to Find It. (27211887)
2016
50
Evaluation of an automated chemiluminescent immunoassay for salivary cortisol measurement. Utility in the diagnosis of Cushing's syndrome. (27580182)
2016

Variations for Cushing's Syndrome

About this section

Expression for genes affiliated with Cushing's Syndrome

About this section
Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

About this section

Pathways related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
110.0CRH, POMC
29.7GNAS, NR3C1
39.2NR3C1, POMC, PRKACA
4
Show member pathways
9.2CYP21A2, HSD11B1, HSD11B2
59.1POMC, PRKACA, PRKAR1A
69.1GNAS, PRKACA
79.0CRH, CYP21A2, GNAS, POMC
8
Show member pathways
8.9CYP21A2, HSD11B1, HSD11B2, POMC
9
Show member pathways
8.8GNAS, PRKACA, PRKAR1A
108.8GNAS, PRKACA, PRKAR1A
11
Show member pathways
8.8GNAS, PRKACA, PRKAR1A
128.8GNAS, PRKACA, PRKAR1A
138.8GNAS, PRKACA, PRKAR1A
14
Show member pathways
8.8GNAS, PRKACA, PRKAR1A
158.8NR3C1, PRKACA, PRKAR1A, SST
16
Show member pathways
8.6GNAS, POMC, PRKACA, PRKAR1A
17
Show member pathways
8.6CRH, GNAS, PRKACA, PRKAR1A
188.5GH1, GNAS, PRKACA, PRKAR1A
19
Show member pathways
8.4GIPR, GNAS, MC2R, PRKACA
208.4CRH, GIPR, GNAS, MC2R, PDE11A, POMC
21
Show member pathways
8.2CYP21A2, GNAS, MC2R, PRKACA
22
Show member pathways
8.1CRH, GH1, GNAS, POMC, PRKACA, PRKAR1A
23
Show member pathways
7.9CRH, GH1, GIPR, GNAS, MC2R, NR3C1

GO Terms for genes affiliated with Cushing's Syndrome

About this section

Cellular components related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cAMP-dependent protein kinase complexGO:00059529.7PRKACA, PRKAR1A
2plasma membrane raftGO:00448539.4PRKACA, PRKAR1A

Biological processes related to Cushing's Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:000862810.6CRH, SST
2activation of protein kinase A activityGO:003419910.0PRKACA, PRKAR1A
3female pregnancyGO:000756510.0CRH, GNAS, HSD11B2
4positive regulation of cAMP biosynthetic processGO:00308199.7CRH, GIPR, GNAS, MC2R
5response to drugGO:00424939.6CRH, GNAS, HSD11B2, SST
6glucocorticoid biosynthetic processGO:00067049.6CRH, CYP21A2, HSD11B1, HSD11B2
7cellular response to glucagon stimulusGO:00713779.5GNAS, PRKACA, PRKAR1A
8renal water homeostasisGO:00030919.5GNAS, PRKACA, PRKAR1A
9steroid metabolic processGO:00082029.3CRH, CYP21A2, HSD11B1

Molecular functions related to Cushing's Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cAMP bindingGO:003055210.4PDE11A, PRKAR1A
2corticotropin-releasing hormone receptor 1 bindingGO:005143010.3CRH, GNAS
311-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:000384510.2HSD11B1, HSD11B2
4hormone activityGO:00051799.8CRH, GH1, POMC, SST
5steroid bindingGO:00054969.4CYP21A2, HSD11B2, NR3C1

Sources for Cushing's Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet