MCID: CSH001
MIFTS: 78

Cushing's Syndrome malady

Endocrine, Reproductive categories

Summaries for Cushing's Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Cushing's Syndrome, also known as cushing syndrome, is related to adrenal gland hyperfunction and ganglioneuroma, and has symptoms including sleep and vigilance disorders, failure to thrive/difficulties for feeding in infancy/growth delay and pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria. An important gene associated with Cushing's Syndrome is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs fludrocortisone and fluorocortisol acetate and the compounds acth and steroid have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

NIH Rare Diseases:43 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. symptoms of cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor. last updated: 2/26/2013

MedlinePlus:34 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:64 Cushing\'s syndrome describes the signs and symptoms associated with prolonged exposure to... more...

Aliases & Classifications for Cushing's Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 49Orphanet, 34MedlinePlus, 61UMLS, 21Genetics Home Reference, 22GTR, 45Novoseek, 10DISEASES, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine, Reproductive


Characteristics (Orphanet epidemiological data):

49
cushing's syndrome:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

cushing's syndrome 8 43 44 49 34
cushing syndrome 43 22 45 49 61
hypercortisolism 21 49
adrenal hyperfunction resulting from pituitary acth excess 43
pituitary-dependant hypercortisolism disorder 21
ectopic adrenocorticotropic hormone syndrome 43
pituitary-dependent cushing's disease 61
pituitary-dependant cushing syndrome 21
pituitary-dependant hypercortisolism 21
pituitary acth hypersecretion 21
adrenal gland hyperfunction 61
pituitary cushing syndrome 21
adrenal cortical adenoma 61
suprarenogenic syndrome 8
adrenal cortex adenoma 43
acth syndrome, ectopic 61
pituitary basophilism 8
ectopic acth syndrome 43
acth syndrome ectopic 45
hyperadrenocorticism 49
cushings syndrome 10
cushing disease 21


External Ids:

Disease Ontology8 DOID:12252
MeSH35 D003480
NCIt40 C2969
ICD9CM27 255.0
MESH via Orphanet36 D000308, D003480
ICD10 via Orphanet26 E24
SNOMED-CT via Orphanet58 275437005, 47270006
UMLS via Orphanet62 C0001622, C0010481
ICD1025 E24.3

Related Diseases for Cushing's Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cushing's Syndrome family:

cushing syndrome, familial cushing syndrome due to ectopic acth secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal gland hyperfunction30.8HSD3BP4, CRH, SST, TRH, POMC, GIPR
2ganglioneuroma30.5CHGA, SYP, POMC
3adrenocortical carcinoma30.4POMC, CYP11B1
4thyroid medullary carcinoma30.4SST, CHGA, POMC
5acromegaly30.4HSD11B2, HSD11B1, CRH, GHSR, SST, TRH
6adrenal adenoma30.2HSD11B2, HSD11B1, CRH, SULT2A1, MC2R, CYP11B1
7prolactinoma30.2GHSR, POMC, TRH, SST, CHGA
8multiple endocrine neoplasia30.2CNC, CHGA
9adenocarcinoma30.2SYP, HSD11B2, SST, HSD11B1, CHGA
10hypokalemia30.2HSD11B2, POMC
11zollinger-ellison syndrome30.2CHGA, SST
12adenoma30.1HSD11B1, HSD11B2, HSD3BP4, LHCGR, SULT2A1, AVPR1B
13hyperandrogenism30.1POMC, CRH, HSD3BP4, LHCGR, SULT2A1
14carcinoid syndrome30.1SST, POMC, CHGA, SYP, GHSR, CRH
15empty sella syndrome29.9TRH, POMC
16hypoglycemia29.9CRH, CHGA, GIP, SST, TRH, POMC
17congenital adrenal hyperplasia29.9CRH, MC2R, CYP11B1, POMC, HSD3BP4
18hyperprolactinemia29.9POMC, TRH, SST, CRH
19nelson syndrome29.9SST, POMC, CRH
20acth-secreting pituitary adenoma29.9CRH, POMC
21carney complex29.9POMC
22pheochromocytoma29.9CHGA, SST, POMC, SYP, CRH
23adrenal carcinoma29.9POMC
24arthritis29.9POMC
25pituitary tumors29.9HSD11B2, CRH, CNC, POMC, TRH, SST
26conn's syndrome29.9CYP11B1, POMC
27addison's disease29.9MC2R, POMC, CRH
28gastrinoma29.9CHGA, SYP, SST
29phaeochromocytoma29.9CHGA
30hypercalcemia29.9AVPR2, CHGA
31neuroendocrine carcinoma29.9SYP, SST, CHGA
32small cell carcinoma10.4
33primary pigmented nodular adrenocortical disease10.3
34adrenal medulla carcinoma10.3
35bladder carcinoma10.3
36olfactory neuroblastoma10.3
37acth-independent macronodular adrenal hyperplasia10.2
38cushing syndrome due to ectopic acth secretion10.2
39n syndrome10.2
40carney triad10.2
41familial hyperaldosteronism type 210.2
42glucagonoma10.2
43pancreatic adenoma10.2
44adrenal adenoma, somatic10.2
45cushing syndrome, familial10.2
46lymphangitis10.1
47nocardiosis10.1
48clear cell sarcoma10.1
49ectopic thymus10.1
50pituitary-dependent cushing's disease10.1

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Clinical Features for Cushing's Syndrome

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 41)
  • sleep and vigilance disorders
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • chronic arterial hypertension
  • diabetes mellitus
  • muscle weakness/flaccidity
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • cataract/lens opacification
  • osteonecrosis/bone infarction
  • obnubilation/coma/lethargia/desorientation
  • myopathy
  • hypokalemia
  • asthenia/fatigue/weakness
  • cardiomyopathy/hypertrophic/dilated
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • telangiectasiae of the skin
  • hirsutism/hypertrichosis/increased body hair
  • thin skin
  • mutiple fractures/bone fragility
  • acne/acnea
  • acute abdominal pain/colic
  • impotence/painful erection/priapism/erection troubles
  • precocious menopause/secondary amenorrhea
  • purpura/petichiae
  • psychosis/schizophrenia/maniac disorder
  • striae
  • sterility/hypofertility
  • round face
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • hypercalcemia
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • cortico-adrenal hyperplasia/hypersecretion
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • adrenal neoplasm/tumor/carcinoma/cancer
  • ecchymoses
  • cushingoid morphotype
  • truncal obesity
  • hypernatremia
  • abnormal fat distribution/lipodystrophy

Drugs & Therapeutics for Cushing's Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cushing's Syndrome

Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Search CenterWatch for Cushing's Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cushing's Syndrome

Sources:
22GTR
See all sources

Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cushing's Syndrome:

33
Skin, Ovary, Liver, Kidney, Lung, Whole blood, Thymus, Cortex, Heart, Skeletal muscle, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Adrenal gland, Prostate, Testis, Cervix, B cells, Endothelial, Hypothalamus, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary, Testis leydig

Animal Models for Cushing's Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cushing's Syndrome

Sources:
51PubMed
See all sources

Articles related to Cushing's Syndrome:

(show top 50)    (show all 980)
idTitleAuthorsYear
1
Cushing's syndrome induced by high-potency topical corticosteroids. (22591336)
2014
2
Factitious Cushing's syndrome masquerading as Cushing's disease. (24111609)
2014
3
Hypercoagulable state in Cushing's syndrome is reversible following remission. (22724622)
2013
4
Thymic neuroendocrine carcinoma producing ectopic adrenocorticotropic hormone and Cushing's syndrome. (24088497)
2013
5
Clinical review: Outcome of bilateral adrenalectomy in Cushing's syndrome: a systematic review. (23956347)
2013
6
Cushing's syndrome due to topical steroid. (24171340)
2013
7
Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome. (23549927)
2013
8
Clinical Usefulness of Corticotropin Releasing Hormone Testing in Subclinical Cushing's Syndrome for Predicting Cortisol Replacement after Adrenalectomy. (22741051)
2012
9
Adrenalectomy for adrenocortical adenoma causing Cushing's syndrome in pregnancy: a case report and review of literature. (22698457)
2012
10
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
11
Cushing's syndrome: all variants, detection, and treatment. (21565673)
2011
12
Cushing's syndrome in a case of thymic carcinoma. (22029011)
2011
13
Diagnosis of cure in Cushing's syndrome: lessons from long-term follow-up. (20616506)
2010
14
Posterior retroperitoneoscopic adrenalectomy for clinical and subclinical Cushing's syndrome. (20143066)
2010
15
Endothelial dysfunction aassociated with hypercortisolism is reversible in Cushing's syndrome. (20023367)
2010
16
The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. (19875485)
2010
17
Difficulties in the diagnosis of ACTH-dependent Cushing's syndrome in a patient after left adrenalectomy and treated with glucocorticoids]. (20041367)
2009
18
Diagnostic value of salivary cortisol in Cushing's syndrome (CS). (18710466)
2009
19
No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo. (19919817)
2009
20
Biochemical markers for cardiovascular risk following treatment in endogenous Cushing's syndrome. (18560257)
2008
21
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. (18413427)
2008
22
Two cases of Cushing's syndrome due to overuse of topical steroid in the diaper area. (18950396)
2008
23
Bone mineral density before and after surgical cure of Cushing's syndrome due to adrenocortical adenoma: prospective study. (18210182)
2008
24
Screening and diagnosis of Cushing's syndrome. (18209856)
2007
25
Primary pigmented nodular adrenocortical disease and Cushing's syndrome. (18209861)
2007
26
Characterization of the metabolic phenotypes of Cushing's syndrome and growth hormone deficiency: a study of body composition and energy metabolism. (16584517)
2006
27
Cushing's Syndrome attributable to ectopic secretion of corticotropin in a patient with two neuroendocrine tumors. (17229662)
2006
28
Agouti related protein (AgRP) is upregulated in Cushing's syndrome. (16320160)
2005
29
Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity? (15240590)
2004
30
Meningioma presenting with Cushing's syndrome: an unusual clinical presentation. (12509860)
2003
31
Myelolipomatous foci in an adrenal adenoma causing Cushing's syndrome? (12665319)
2003
32
Virilizing adrenocortical adenoma with Cushing's syndrome, thyroid papillary carcinoma and hypergastrinemia in a middle-aged woman. (12803238)
2003
33
Cushing's syndrome due to phaeochromocytoma secreting the precursors of adrenocorticotropin. (11134141)
2000
34
A case of acromegaly accompanied by adrenal preclinical Cushing's syndrome. (10426577)
1999
35
Cushing's syndrome in a patient with a corticotropin-releasing hormone-producing pheochromocytoma. (15251695)
1999
36
Desmopressin stimulation test for diagnosis of ACTH-dependent Cushing's syndrome. (9466324)
1997
37
Effect of arginine and pyridostigmine on the GHRH-induced GH rise in obesity and Cushing's syndrome. (7735336)
1995
38
Persistent GHRH-induced PRL secretion in Cushing's syndrome, obesity and exogenous hypercortisolism. (7886270)
1994
39
Failure of somatostatin analogue to control Cushing's syndrome in two cases of ACTH-producing carcinoid tumours. (1424169)
1992
40
Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome. (1672788)
1991
41
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome. (1835446)
1991
42
Value of the corticoliberine test in the etiologic diagnosis of Cushing's syndrome]. (2158088)
1990
43
Management of Cushing's syndrome secondary to adrenal adenoma during pregnancy. (2247832)
1990
44
Plasma ACTH responses to cortisol infusion are similar in patients with primary hypoadrenalism and patients studied some years after bilateral adrenalectomy for Cushing's syndrome. (2557986)
1989
45
A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. (2985302)
1985
46
Chromophobe adenoma of the pituitary with Cushing's syndrome and skin pigmentation. (514937)
1979
47
Cushing's syndrome due to adrenal adenoma with persistent diurnal cortisol secretory rhythm. (206799)
1978
48
Cortisol secretion in Nelson syndrome: Persistence after "total" adrenalectomy for Cushing syndrome. (171463)
1975
49
Hypertensive crisis followed by adrenocortical insufficiency after unilateral adrenal phlebography in a patient with Cushing's syndrome. (4424050)
1974
50
Cushing's syndrome associated with a "corticotrophin"-producing bronchial neoplasm neoplasm (results of corticotrophin assays and of pituitary-adrenal function tests). (4293813)
1967

Genetic Variations for Cushing's Syndrome

Expression for genes affiliated with Cushing's Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cushing's Syndrome

Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Compounds for genes affiliated with Cushing's Syndrome

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1acth4511.2HSD11B2, HSD11B1, HSD3BP4, LHCGR, CRH, GHSR
2steroid4511.1SULT2A1, MC2R, CYP11B1, POMC, CHGA, NR2F1
3testosterone45 60 11 2414.1HSD11B1, HSD3BP4, SULT2A1, MC2R, CYP11B1, POMC
4dexamethasone45 50 29 1114.1CHGA, SYP, GHSR, CRH, HSD3BP4, HSD11B2
5arginine4511.1GHSR, AVPR1B, HSD11B2, LHCGR, CRH, AVPR2
6ribonucleic acid4511.1CHGA, POMC, GIPR, CYP11B1, HSD3BP4, LHCGR
7progesterone45 60 29 11 2415.1HSD11B1, LHCGR, CRH, SYP, HSD3BP4, CHGA
8forskolin45 50 1113.1SULT2A1, MC2R, CYP11B1, GIP, POMC, GHSR
9adenylate4511.1MC2R, AVPR2, TRH, GIP, CHGA, GHSR
10cyclic amp45 2412.0HSD3BP4, CYP11B1, AVPR2, SYP, LHCGR, CRH
11hydrocortisone45 2 60 1114.0MC2R, HSD11B2, HSD11B1, CRH, GHSR, POMC
123beta-hydroxysteroid4511.0CYP11B1, MC2R, POMC, LHCGR, HSD11B2, HSD11B1
13estradiol45 11 2413.0SULT2A1, POMC, TRH, NR2F1, SYP, GHSR
1411beta-hydroxysteroid4511.0MC2R, CYP11B1, POMC, CRH, HSD3BP4, HSD11B1
15corticosterone45 60 2413.0AVPR1B, CRH, LHCGR, HSD11B1, HSD11B2, POMC
16metyrapone60 45 1113.0MC2R, CYP11B1, POMC, SST, HSD11B1, CRH
17dhea4511.0HSD11B1, HSD3BP4, CRH, POMC, SULT2A1, HSD11B2
18dopamine45 29 11 2414.0POMC, GHSR, SYP, TRH, CRH, SST
19androstenedione45 2412.0MC2R, HSD3BP4, HSD11B2, CRH, HSD11B1, POMC
20cholesterol45 29 11 2414.0MC2R, SULT2A1, CYP11B1, CHGA, SYP, HSD11B1
21octreotide45 60 29 1114.0GHSR, CHGA, SST, POMC, TRH, CRH
22calcium45 50 11 2414.0HSD3BP4, LHCGR, GHSR, SYP, CHGA, TRH
23cortisone45 2411.9CRH, HSD11B2, CYP11B1, POMC, HSD11B1
24cortisol29 2411.9HSD11B2, CYP11B1, POMC, HSD11B1
25estrogen4510.9TRH, NR2F1, HSD11B1
26ketoconazole45 29 11 2413.9POMC, SST, CRH, HSD3BP4, CYP11B1
27dehydroepiandrosterone sulfate4510.9SULT2A1, HSD3BP4, CRH, POMC, MC2R
28hexarelin45 2911.9CRH, GHSR, POMC, SST
29doca4510.9HSD3BP4, POMC, HSD11B2, CYP11B1
30gnrh4510.9LHCGR, CRH, CHGA, SST, TRH, POMC
31norepinephrine45 11 2412.9POMC, SYP, CHGA, TRH
32betamethasone45 1111.9POMC, HSD11B2, CRH, SYP
33hcrh4510.9CRH, GHSR, POMC
34gaba4510.9SST, CRH, POMC, SYP, TRH, CHGA
35pitressin4510.9CRH, SST, POMC
3617-hydroxyprogesterone45 2411.8CYP11B1, HSD3BP4, POMC, CRH
37mifepristone45 60 29 1113.8HSD11B2, HSD3BP4, HSD11B1, CRH, POMC
38spironolactone50 45 60 29 1114.8CYP11B1, HSD11B2, POMC, CRH
39desmopressin45 60 29 1113.8AVPR1B, POMC, AVPR2, CRH
40histidine4510.8CHGA, CYP11B1, AVPR2, SYP, LHCGR, GIP
41alanine4510.8CRH, LHCGR, HSD11B1, GIP, AVPR2, MC2R
42terlipressin45 1111.8AVPR1B, SST, AVPR2
43111in-pentetreotide4510.7SYP, CHGA, SST
445-hydroxytryptamine4510.7SST, POMC, CHGA, SYP, CRH
45naloxone45 50 29 1113.7POMC, SST, TRH, CRH
46acetylcholine45 50 29 11 2414.6POMC, TRH, SST, CHGA, SYP, CRH
47clonidine45 29 1112.5POMC, TRH, SST, CHGA
4811 deoxycortisol4510.5CRH, POMC, CYP11B1
49ghrp4510.4GHSR, SST, TRH
50glycyrrhetinic acid45 2411.2HSD11B2, HSD11B1, HSD3BP4

GO Terms for genes affiliated with Cushing's Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.5GIP, POMC
2secretory granuleGO:03014110.2POMC, TRH, CHGA

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.8CYP11B1, CRH, HSD11B1, HSD11B2
2G-protein coupled receptor signaling pathwayGO:00718610.8LHCGR, GHSR, SST, MC2R, AVPR1B
3activation of adenylate cyclase activityGO:00719010.8AVPR2, GIPR, LHCGR
4positive regulation of insulin secretionGO:03202410.7GIP, GIPR, TRH
5hormone-mediated apoptotic signaling pathwayGO:00862810.7SST, CRH
6steroid metabolic processGO:00820210.7HSD11B1, CYP11B1, SULT2A1
7response to glucose stimulusGO:00974910.6TRH, GIPR, GIP
8regulation of blood pressureGO:00821710.6CHGA, POMC, CYP11B1
9response to drugGO:04249310.5GIP, SST, CRH, HSD11B2
10positive regulation of cAMP-mediated signalingGO:04395010.5GIP, LHCGR
11response to foodGO:03209410.4HSD11B2, GHSR
12female pregnancyGO:00756510.2GIP, CRH, HSD11B2

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vasopressin receptor activityGO:00500010.5AVPR1B, AVPR2
2hormone activityGO:00517910.5GIP, POMC, SST, CRH
311-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00384510.2HSD11B1, HSD11B2

Products for genes affiliated with Cushing's Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cushing's Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet