MCID: CSH001
MIFTS: 83

Cushing's Syndrome malady

Endocrine diseases, Reproductive diseases categories

Summaries for Cushing's Syndrome

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:43 Cushing's syndrome, also called , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( a substance that controls the release of cortisol) can also spur overproduction of cortisol. Tumors of the adrenal gland and ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body) can cause similar problems with cortisol balance. Common symptoms of Cushing's syndrome include upper body obesity, severe fatigue and muscle weakness, high blood pressure, backache, elevated blood sugar, easy bruising, and bluish-red stretch marks on the skin. In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Neurological symptoms include difficulties with memory and neuromuscular disorders.

MalaCards: Cushing's Syndrome, also known as cushing syndrome, is related to adrenocortical carcinoma and adrenal adenoma, and has symptoms including myopathy, osteonecrosis/bone infarction and hypernatremia. An important gene associated with Cushing's Syndrome is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The drugs fludrocortisone and fluorocortisol acetate and the compounds acth and steroid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, adrenal gland and testes, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Disease Ontology:8 An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

Genetics Home Reference:21 Cushing disease is caused by elevated levels of a hormone called cortisol, which leads to a wide variety of signs and symptoms. This condition usually occurs in adults between the ages of 20 and 50; however, children may also be affected. The first sign of this condition is usually weight gain around the trunk and in the face. Affected individuals may get stretch marks (striae) on their thighs and abdomen and bruise easily. Individuals with Cushing disease can develop a hump on their upper back caused by abnormal deposits of fat. People with this condition can have muscle weakness, severe tiredness, and progressively thin and brittle bones that are prone to fracture (osteoporosis). They also have a weakened immune system and are at an increased risk of infections. Cushing disease can cause mood disorders such as anxiety, irritability, and depression. This condition can also affect a person's concentration and memory. People with Cushing disease have an increased chance of developing high blood pressure (hypertension) and diabetes. Women with Cushing disease may experience irregular menstruation and have excessive hair growth (hirsutism) on their face, abdomen, and legs. Men with Cushing disease may have erectile dysfunction. Children with Cushing disease typically experience slow growth.

NIH Rare Diseases:42 Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. symptoms of cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor. last updated: 2/26/2013

MedlinePlus:33 Cushing's syndrome is a hormonal disorder. the cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to cushing's. some kinds of tumors produce a hormone that can cause your body to make too much cortisol. cushing's syndrome is rare. some symptoms are upper body obesity thin arms and legs severe fatigue and muscle weakness high blood pressure high blood sugar easy bruising lab tests can show if you have it and find the cause. your treatment will depend on why you have too much cortisol. if it is because you have been taking synthetic hormones, a lower dose may control your symptoms. if the cause is a tumor, surgery and other therapies may be needed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:63 Cushing\'s syndrome describes the signs and symptoms associated with prolonged exposure to... more...

Aliases & Classifications for Cushing's Syndrome

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 48Orphanet, 33MedlinePlus, 60UMLS, 21Genetics Home Reference, 22GTR, 44Novoseek, 10DISEASES, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
cushing's syndrome:
Inheritance: Autosomal dominant,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

cushing's syndrome 8 42 43 48 33
cushing syndrome 42 22 44 48 60
hypercortisolism 21 48
adrenal hyperfunction resulting from pituitary acth excess 42
pituitary-dependant hypercortisolism disorder 21
ectopic adrenocorticotropic hormone syndrome 42
pituitary-dependent cushing's disease 60
pituitary-dependant cushing syndrome 21
pituitary-dependant hypercortisolism 21
pituitary acth hypersecretion 21
adrenal gland hyperfunction 60
pituitary cushing syndrome 21
adrenal cortical adenoma 60
suprarenogenic syndrome 8
adrenal cortex adenoma 42
acth syndrome, ectopic 60
pituitary basophilism 8
ectopic acth syndrome 42
acth syndrome ectopic 44
hyperadrenocorticism 48
cushings syndrome 10
cushing disease 21


External Ids:

Disease Ontology8 DOID:12252
MeSH34 D003480
NCIt39 C2969
ICD9CM27 255.0
MESH via Orphanet35 D000308, D003480
SNOMED-CT via Orphanet57 275437005, 47270006
ICD10 via Orphanet26 E24.0, E24.1, E24.2 E24.3, E24.4, E24.8, E24.9, more
UMLS via Orphanet61 C0001622, C0010481
ICD1025 E24.3

Related Diseases for Cushing's Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cushing's Syndrome family:

Cushing Syndrome, Familial Cushing Syndrome Due to Ectopic Acth Secretion

Diseases related to Cushing's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1adrenocortical carcinoma30.5CYP11B1, POMC
2adrenal adenoma30.4HSD11B2, HSD11B1, CRH, SULT2A1, MC2R, CYP11B1
3acth-secreting pituitary adenoma30.4POMC, CRH
4thyroiditis30.3TRH, POMC
5pancreatitis30.3SST
6thyroid medullary carcinoma30.3POMC, SST, CHGA
7acromegaly30.3CNC, POMC, TRH, SST, GHSR, CRH
8prolactinoma30.2GHSR, CHGA, SST, TRH, POMC
9nelson syndrome30.2CRH, SST, POMC
10adrenal gland hyperfunction30.1CNC, GIPR, POMC, TRH, SST, CRH
11adenocarcinoma30.1HSD11B2, HSD11B1, SYP, CHGA, SST
12hypogonadism30.1LHCGR, CRH, TRH, POMC
13hypothyroidism30.1POMC, TRH, GHSR
14hypokalemia30.1POMC, HSD11B2
15zollinger-ellison syndrome30.1SST, CHGA
16lung cancer30.1SYP, CHGA, SST, POMC
17adenoma30.1HSD11B1, HSD11B2, HSD3BP4, AVPR1B, MC2R, CYP11B1
18pituitary adenoma30.1CRH, GHSR, SYP, CHGA, SST, TRH
19obesity30.1HSD11B2, HSD11B1, CRH, GHSR, TRH, POMC
20congenital adrenal hyperplasia30.1HSD3BP4, CRH, POMC, CYP11B1, MC2R
21leydig cell tumor30.1POMC, LHCGR, HSD3BP4
22adrenal carcinoma30.1POMC
23hyperandrogenism30.1HSD3BP4, LHCGR, CRH, POMC, SULT2A1
24hyperaldosteronism30.1HSD11B2, POMC, CYP11B1
25empty sella syndrome29.9TRH, POMC
26hypoglycemia29.8CRH, CHGA, SST, TRH, POMC, GIP
27diabetes mellitus29.8HSD11B1, SST, POMC, GIPR, GIP
28hypertension29.8CYP11B1, POMC, CRH, HSD11B1, HSD11B2
29neuroendocrine tumor29.8POMC, SST, CHGA, SYP, GHSR
30gastrinoma29.8SYP, CHGA, SST
31ganglioneuroma29.8SYP, CHGA, POMC
32phaeochromocytoma29.8CHGA
33hyperthyroidism29.8TRH, SST
34ganglioneuroblastoma29.8SYP
35pheochromocytoma29.8POMC, SST, CHGA, SYP, CRH
36hypercalcemia29.8CHGA, AVPR2
37neuroendocrine carcinoma29.8SYP, CHGA, SST
38neuroblastoma29.8SYP
39hyperprolactinemia29.8POMC, TRH, SST, CRH
40carney complex29.8POMC
41arthritis29.8POMC
42conn's syndrome29.8POMC, CYP11B1
43small cell carcinoma10.4
44cushing syndrome due to ectopic acth secretion10.4
45pigmentation disease10.3
46acth-independent macronodular adrenal hyperplasia10.3
47mccune albright syndrome10.3
48olfactory neuroblastoma10.2
49bladder carcinoma10.2
50cervicitis10.2

Graphical network of the top 20 diseases related to Cushing's Syndrome:



Diseases related to cushing's syndrome

Clinical Features for Cushing's Syndrome

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 41)
  • myopathy
  • osteonecrosis/bone infarction
  • hypernatremia
  • hypercalcemia
  • hyperlipidemia/hypercholesterolemia/hypertriglyceridemia
  • adrenal neoplasm/tumor/carcinoma/cancer
  • telangiectasiae of the skin
  • acne/acnea
  • psychosis/schizophrenia/maniac disorder
  • obnubilation/coma/lethargia/desorientation
  • sterility/hypofertility
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • urinary/renal lithiasis/kidney stones/nephritic colic
  • chronic arterial hypertension
  • hirsutism/hypertrichosis/increased body hair
  • ecchymoses
  • purpura/petichiae
  • striae
  • cushingoid morphotype
  • failure to thrive/difficulties for feeding in infancy/growth delay
  • abnormal fat distribution/lipodystrophy
  • truncal obesity
  • impotence/painful erection/priapism/erection troubles
  • thin skin
  • diabetes mellitus
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • sleep and vigilance disorders
  • precocious menopause/secondary amenorrhea
  • cortico-adrenal hyperplasia/hypersecretion
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • cardiomyopathy/hypertrophic/dilated
  • acute abdominal pain/colic
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • cataract/lens opacification
  • asthenia/fatigue/weakness
  • hypokalemia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • mutiple fractures/bone fragility
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • muscle weakness/flaccidity
  • round face

Drugs & Therapeutics for Cushing's Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cushing's Syndrome

Drug clinical trials:

Search ClinicalTrials for Cushing's Syndrome

Search NIH Clinical Center for Cushing's Syndrome

Search CenterWatch for Cushing's Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cushing's Syndrome

About this section
Sources:
22GTR
See all sources

Genetic tests related to Cushing's Syndrome:

id Genetic test Affiliating Genes
1 Cushing's Syndrome22

Anatomical Context for Cushing's Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cushing's Syndrome:

32
Pituitary, Adrenal gland, Testes, Bone, Adrenal cortex, Cortex, Skin, Kidney, Thyroid, Lung, Heart, Prostate, Liver, Ovary, Pancreatic islet, Thymus, Pancreas, Testis, Eye, Hypothalamus, Endothelial, Skeletal muscle, Colon, Adipocyte, Cervix

Animal Models for Cushing's Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cushing's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9AVPR1B, HSD11B2, HSD11B1, LHCGR, CRH, GHSR
2MP:000537910.8HSD11B1, LHCGR, CRH, CHGA, TRH, POMC
3MP:000538610.8CRH, LHCGR, HSD11B1, HSD11B2, GHSR, NR2F1
4MP:000537510.6HSD11B1, LHCGR, GHSR, POMC, CYP11B1, MC2R
5MP:000363110.6HSD11B1, CRH, SYP, NR2F1, SST, TRH
6MP:000301210.6POMC, SST, NR2F1, SYP, GHSR, HSD11B2
7MP:000537810.5GHSR, CRH, LHCGR, HSD11B1, CHGA, SST
8MP:000536710.3HSD11B2, LHCGR, CHGA, POMC, CYP11B1, AVPR2

Publications for Cushing's Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Cushing's Syndrome:

(show top 50)    (show all 896)
idTitleAuthorsYear
1
Glucocorticoid-induced osteoporosis: lessons from Cushing's syndrome. (23452135)
2013
2
Multisystem morbidity and mortality in Cushing's syndrome: a cohort study. (23533241)
2013
3
Cardio-respiratory failure secondary to ectopic Cushing's syndrome as the index presentation of small-cell lung cancer. (23946525)
2013
4
Significantly high level of late-night free cortisol to creatinine ratio in urine specimen in patients with subclinical Cushing's syndrome. (23480295)
2013
5
Routine Screening for Cushing's Syndrome Is Not Required in Patients Presenting with Obesity. (23840961)
2013
6
Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome. (23549927)
2013
7
Von Hippel Lindau disease with metastatic pancreatic neuroendocrine tumor causing ectopic Cushing's syndrome. (23524618)
2013
8
Reversal of Cushing's syndrome by vandetanib in medullary thyroid carcinoma. (23924025)
2013
9
Retroperitoneal adrenal-sparing surgery for the treatment of Cushing's syndrome caused by adrenocortical adenoma: 8-year experience with 87 patients. (22382766)
2012
10
Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics. (22934113)
2012
11
A case of Cushing's syndrome in pregnancy. (21528482)
2011
12
Laparoscopic treatment of Cushing's syndrome in a woman in late pregnancy - a case presentation. (23255991)
2011
13
Cushing's syndrome in a case of thymic carcinoma. (22029011)
2011
14
Overt immune dysfunction after Cushing's syndrome remission: a consecutive case series and review of the literature. (21816785)
2011
15
Thymic neuroendocrine carcinoma presenting as cushing's syndrome: treatment with octreotide combined with surgery and radiotherapy. (21346385)
2011
16
Exogenous Cushing's syndrome due to topical corticosteroid application: case report and review literature. (20972726)
2010
17
Metabolic syndrome in Cushing's syndrome. (20829627)
2010
18
Medical treatment of Cushing's syndrome: glucocorticoid receptor antagonists and mifepristone. (20829633)
2010
19
A child with Cushing's syndrome--etiological clue from adrenal imaging (pediatric Cushing's syndrome). (21714455)
2010
20
Iatrogenic Cushing's syndrome, diabetes mellitus and secondary adrenal failure in a human immunodeficiency virus patient treated with ritonavir boosted atazanavir and fluticasone]. (19419710)
2009
21
Development and validation of a 0.5 mg dexamethasone suppression test as an initial screening test for the diagnosis of ACTH-dependent Cushing's syndrome. (19706991)
2009
22
Isolated Cushing's syndrome: an unusual presentation of McCune-Albright syndrome in the neonatal period. (19844118)
2009
23
Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing's syndrome. (19794285)
2009
24
Carbamazepine and falsely positive screening tests for Cushing's syndrome. (19182847)
2009
25
Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire. (18426820)
2008
26
Phaeochromocytoma combined with subclinical Cushing's syndrome and pituitary microadenoma. (18544281)
2008
27
Surgery for Cushing's syndrome: an historical review and recent ten-year experience. (18196319)
2008
28
Pharmacological management of Cushing's syndrome: an update. (18209872)
2007
29
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17581261)
2007
30
Desmopressin test during petrosal sinus sampling: a valuable tool to discriminate pituitary or ectopic ACTH-dependent Cushing's syndrome. (17766708)
2007
31
Imaging in Cushing's syndrome. (18209870)
2007
32
Pitfalls in the diagnosis of Cushing's syndrome. (18209858)
2007
33
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome. (16352372)
2006
34
Expression of ACTH receptor pathway genes in glucose-dependent insulinotrophic peptide (GIP)-dependent Cushing's syndrome. (16402925)
2006
35
Analysis of the putative regulatory region of the gastric inhibitory polypeptide receptor gene in food-dependent Cushing's syndrome. (15276624)
2004
36
Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action. (12943516)
2003
37
Intraadrenal adrenocorticotropin production in a case of bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. (12843140)
2003
38
Biochemical and imaging evaluation of Cushing's syndrome. (11961502)
2002
39
Classic and recent etiologies of Cushing's syndrome: diagnosis and therapy. (15765624)
2002
40
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. (11837535)
2001
41
Combined primary aldosteronism and preclinical Cushing's syndrome: an unusual case presentation of adrenal adenoma. (11768734)
2001
42
Circulating adrenomedullin is increased in patients with corticotropin-dependent Cushing's syndrome due to pituitary adenoma. (10877203)
2000
43
Cushing's syndrome due to an ectopic ACTH-secreting pituitary tumour mimicking occult paraneoplastic ectopic ACTH production. (10619988)
1999
44
Aberrant expression of the GIP (Gastric Inhibitory Polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. (10333644)
1998
45
The effect of ketoconazole in pre-operative treatment in Cushing's syndrome: three cases report. (9041768)
1996
46
Clinical usefulness of pharmacological treatment of Cushing's syndrome]. (8164384)
1994
47
The corticotropin-releasing factor test in the differential diagnosis of Cushing's syndrome: a comparison with the lysine-vasopressin test. (2239082)
1990
48
Value of the corticoliberine test in the etiologic diagnosis of Cushing's syndrome]. (2158088)
1990
49
A study of hypothalamic-pituitary-adrenal suppression following curative surgery for Cushing's syndrome due to adrenal adenoma. (3030034)
1987
50
Pancreatic islet cell tumor associated with Cushing's syndrome. (6097131)
1984

Genetic Variations for Cushing's Syndrome

About this section

Expression for genes affiliated with Cushing's Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cushing's Syndrome

Search GEO for disease gene expression data for Cushing's Syndrome.

Pathways for genes affiliated with Cushing's Syndrome

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
See all sources

Compounds for genes affiliated with Cushing's Syndrome

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1acth4411.2HSD11B2, HSD11B1, HSD3BP4, LHCGR, CRH, GHSR
2steroid4411.1SULT2A1, MC2R, CYP11B1, POMC, CHGA, NR2F1
3testosterone44 59 11 2414.1HSD11B1, HSD3BP4, SULT2A1, MC2R, CYP11B1, POMC
4dexamethasone44 49 28 1114.1CHGA, SYP, GHSR, CRH, HSD3BP4, HSD11B2
5arginine4411.1GHSR, AVPR1B, HSD11B2, LHCGR, CRH, AVPR2
6ribonucleic acid4411.1CHGA, POMC, GIPR, CYP11B1, HSD3BP4, LHCGR
7progesterone44 59 28 11 2415.1HSD11B1, LHCGR, CRH, SYP, HSD3BP4, CHGA
8forskolin44 49 1113.1SULT2A1, MC2R, CYP11B1, GIP, POMC, GHSR
9adenylate4411.1MC2R, AVPR2, TRH, GIP, CHGA, GHSR
10cyclic amp44 2412.0HSD3BP4, CYP11B1, AVPR2, SYP, LHCGR, CRH
11hydrocortisone44 2 59 1114.0MC2R, HSD11B2, HSD11B1, CRH, GHSR, POMC
123beta-hydroxysteroid4411.0CYP11B1, MC2R, POMC, LHCGR, HSD11B2, HSD11B1
13estradiol44 11 2413.0SULT2A1, POMC, TRH, NR2F1, SYP, GHSR
1411beta-hydroxysteroid4411.0MC2R, CYP11B1, POMC, CRH, HSD3BP4, HSD11B1
15corticosterone44 59 2413.0AVPR1B, CRH, LHCGR, HSD11B1, HSD11B2, POMC
16metyrapone59 44 1113.0MC2R, CYP11B1, POMC, SST, HSD11B1, CRH
17dhea4411.0HSD11B1, HSD3BP4, CRH, POMC, SULT2A1, HSD11B2
18dopamine44 28 11 2414.0POMC, GHSR, SYP, TRH, CRH, SST
19androstenedione44 2412.0MC2R, HSD3BP4, HSD11B2, CRH, HSD11B1, POMC
20cholesterol44 28 11 2414.0MC2R, SULT2A1, CYP11B1, CHGA, SYP, HSD11B1
21octreotide44 59 28 1114.0GHSR, CHGA, SST, POMC, TRH, CRH
22calcium44 49 11 2414.0HSD3BP4, LHCGR, GHSR, SYP, CHGA, TRH
23cortisone44 2411.9CRH, HSD11B2, CYP11B1, POMC, HSD11B1
24cortisol28 2411.9HSD11B2, CYP11B1, POMC, HSD11B1
25estrogen4410.9TRH, NR2F1, HSD11B1
26ketoconazole44 28 11 2413.9POMC, SST, CRH, HSD3BP4, CYP11B1
27dehydroepiandrosterone sulfate4410.9SULT2A1, HSD3BP4, CRH, POMC, MC2R
28hexarelin44 2811.9CRH, GHSR, POMC, SST
29doca4410.9HSD3BP4, POMC, HSD11B2, CYP11B1
30gnrh4410.9LHCGR, CRH, CHGA, SST, TRH, POMC
31norepinephrine44 11 2412.9POMC, SYP, CHGA, TRH
32betamethasone44 1111.9POMC, HSD11B2, CRH, SYP
33hcrh4410.9CRH, GHSR, POMC
34gaba4410.9SST, CRH, POMC, SYP, TRH, CHGA
35pitressin4410.9CRH, SST, POMC
3617-hydroxyprogesterone44 2411.8CYP11B1, HSD3BP4, POMC, CRH
37mifepristone44 59 28 1113.8HSD11B2, HSD3BP4, HSD11B1, CRH, POMC
38spironolactone49 44 59 28 1114.8CYP11B1, HSD11B2, POMC, CRH
39desmopressin44 59 28 1113.8AVPR1B, POMC, AVPR2, CRH
40histidine4410.8CHGA, CYP11B1, AVPR2, SYP, LHCGR, GIP
41alanine4410.8CRH, LHCGR, HSD11B1, GIP, AVPR2, MC2R
42terlipressin44 1111.8AVPR1B, SST, AVPR2
43111in-pentetreotide4410.7SYP, CHGA, SST
445-hydroxytryptamine4410.7SST, POMC, CHGA, SYP, CRH
45naloxone44 49 28 1113.7POMC, SST, TRH, CRH
46acetylcholine44 49 28 11 2414.6POMC, TRH, SST, CHGA, SYP, CRH
47clonidine44 28 1112.5POMC, TRH, SST, CHGA
4811 deoxycortisol4410.5CRH, POMC, CYP11B1
49ghrp4410.4GHSR, SST, TRH
50glycyrrhetinic acid44 2411.2HSD11B2, HSD11B1, HSD3BP4

GO Terms for genes affiliated with Cushing's Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.5GIP, POMC
2secretory granuleGO:03014110.2POMC, TRH, CHGA

Biological processes related to Cushing's Syndrome according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1glucocorticoid biosynthetic processGO:00670410.8CYP11B1, CRH, HSD11B1, HSD11B2
2G-protein coupled receptor signaling pathwayGO:00718610.8LHCGR, GHSR, SST, MC2R, AVPR1B
3activation of adenylate cyclase activityGO:00719010.8AVPR2, GIPR, LHCGR
4positive regulation of insulin secretionGO:03202410.7GIP, GIPR, TRH
5hormone-mediated apoptotic signaling pathwayGO:00862810.7SST, CRH
6steroid metabolic processGO:00820210.7HSD11B1, CYP11B1, SULT2A1
7response to glucose stimulusGO:00974910.6TRH, GIPR, GIP
8regulation of blood pressureGO:00821710.6CHGA, POMC, CYP11B1
9response to drugGO:04249310.5GIP, SST, CRH, HSD11B2
10positive regulation of cAMP-mediated signalingGO:04395010.5GIP, LHCGR
11response to foodGO:03209410.4HSD11B2, GHSR
12female pregnancyGO:00756510.2GIP, CRH, HSD11B2

Molecular functions related to Cushing's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vasopressin receptor activityGO:00500010.5AVPR1B, AVPR2
2hormone activityGO:00517910.5GIP, POMC, SST, CRH
311-beta-hydroxysteroid dehydrogenase [NAD(P)] activityGO:00384510.2HSD11B1, HSD11B2

Products for genes affiliated with Cushing's Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cushing's Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet