MCID: CTN004
MIFTS: 36

Cutaneous Fibrous Histiocytoma malady

Skin, Cancer categories

Summaries for Cutaneous Fibrous Histiocytoma

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cutaneous Fibrous Histiocytoma, also known as dermatofibroma, is related to fibrous histiocytoma and dermatofibrosarcoma. An important gene associated with Cutaneous Fibrous Histiocytoma is LYZ (lysozyme), and among its related pathways is Aurora B signaling. The compounds orcein and toluidine have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and t cells.

Aliases & Classifications for Cutaneous Fibrous Histiocytoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 43NIH Rare Diseases, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Aliases & Descriptions:

cutaneous fibrous histiocytoma 8 10 61
dermatofibroma 8 43 45
fibrohistiocytic tumor 8 61
benign cutaneous fibrous histiocytoma 8
dermatofibroma, no icd-o subtype 8
fibrous histiocytoma of skin 8
histiocytoma, benign fibrous 61
sclerosing angioma of skin 8
fibrohistiocytic neoplasm 8
fibrous xanthoma of skin 8
pleomorphic fibroma 8
sclerosing angioma 8
dermatofibroma nos 8


Related Diseases for Cutaneous Fibrous Histiocytoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cutaneous Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma31.2VIM, F13A1, DES, CD34
2dermatofibrosarcoma30.3FOXO4
3dermatofibrosarcoma protuberans30.3VIM, F13A1, DES, CD34, MMP11
4basal cell carcinoma30.2MMP11, CD34, F13A1
5hemangioendothelioma29.9CD34
6spindle cell sarcoma29.9VIM, DES
7granular cell tumor29.9CD68, DES, VIM
8malignant skin fibrous histiocytoma10.4
9pleomorphic lipoma10.3
10atypical lipomatous tumor10.3
11pleomorphic liposarcoma10.1
12skin lipoma10.1
13myxofibrosarcoma10.1
14clear cell acanthoma10.1
15skin sarcoma10.1
16arthritis10.0LYZ
17eye disease10.0LYZ
18metanephric adenoma10.0B3GAT1
19ossifying fibromyxoid tumor10.0B3GAT1
20hepatitis10.0HAVCR1
21germ cell cancer10.0B3GAT1
22sarcoidosis10.0LYZ
23meningitis10.0LYZ
24dermatitis10.0F13A1
25pulmonary embolism10.0F13A1
26adenomatoid tumor10.0VIM
27hypersensitivity reaction type ii disease10.0LYZ, CD68
28multicentric reticulohistiocytosis10.0CD68, HAVCR1
29vascular cancer10.0CD34
30myoepithelioma10.0VIM
31infantile myofibromatosis10.0DES
32adenoma10.0B3GAT1, MMP11
33letterer-siwe disease10.0F13A1, CD68
34atherosclerosis10.0CD68, F13A1
35histiocytosis10.0LYZ, CD68, HAVCR1
36myeloid sarcoma10.0CD34, LYZ
37human immunodeficiency virus infectious disease10.0CD34, B3GAT1
38acute leukemia10.0CD34, FOXO4
39perineurioma10.0CD34, VIM
40angiosarcoma10.0CD34, VIM
41epidermolysis bullosa simplex10.0DES
42epithelioid sarcoma10.0VIM, CD34
43glomus tumor10.0VIM, DES
44epithelioid leiomyosarcoma10.0DES, VIM
45mesenchymal chondrosarcoma10.0DES, VIM
46angiomyolipoma10.0DES, VIM
47pseudosarcomatous fibromatosis10.0VIM, DES
48malignant peripheral nerve sheath tumor10.0VIM, CD34
49spindle cell carcinoma10.0VIM, DES
50alveolar soft part sarcoma10.0VIM, DES

Graphical network of the top 20 diseases related to Cutaneous Fibrous Histiocytoma:



Diseases related to cutaneous fibrous histiocytoma

Clinical Features for Cutaneous Fibrous Histiocytoma

Drugs & Therapeutics for Cutaneous Fibrous Histiocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cutaneous Fibrous Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Fibrous Histiocytoma

Search NIH Clinical Center for Cutaneous Fibrous Histiocytoma

Search CenterWatch for Cutaneous Fibrous Histiocytoma

Genetic Tests for Cutaneous Fibrous Histiocytoma

Anatomical Context for Cutaneous Fibrous Histiocytoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cutaneous Fibrous Histiocytoma:

33
Skin, Monocytes, T cells

Animal Models for Cutaneous Fibrous Histiocytoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Cutaneous Fibrous Histiocytoma

Sources:
51PubMed
See all sources

Articles related to Cutaneous Fibrous Histiocytoma:

(show all 29)
idTitleAuthorsYear
1
Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. (23426120)
2013
2
A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases. (23347814)
2013
3
Cutaneous inflammatory malignant fibrous histiocytoma presenting with a leukemoid reaction: a case report and review of the literature. (22844297)
2012
4
Management of unusual cutaneous malignancies: atypical fibroxanthoma, malignant fibrous histiocytoma, sebaceous carcinoma, extramammary Paget disease. (21421146)
2011
5
Atypical cutaneous fibrous histiocytoma: an unusual and misleading variant of fibrous histiocytoma. (22937387)
2011
6
Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma. (18435726)
2009
7
Recurrent cutaneous malignant fibrous histiocytoma. (19264583)
2009
8
A study of monocytic and dendritic cell markers in benign cutaneous fibrous histiocytoma (dermatofibroma). (18462367)
2008
9
A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". (18474466)
2008
10
Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). (17414448)
2007
11
Cutaneous malignant fibrous histiocytoma in an HIV-positive patient. (17207179)
2007
12
Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly. (16434321)
2006
13
Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma. (17004978)
2006
14
Cutaneous malignant fibrous histiocytoma of the scalp in a renal transplant recipient. (16403118)
2006
15
Primary cutaneous malignant fibrous histiocytoma: a case report. (16810139)
2006
16
Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. (16008697)
2005
17
The value of immunohistochemistry in atypical cutaneous fibrous histiocytoma. (15365367)
2004
18
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). (12139632)
2002
19
Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma. (10461644)
1999
20
Recurring atypical ("pseudosarcomatous") cutaneous fibrous histiocytoma. (9649666)
1998
21
Cutaneous fibrous histiocytoma. (9158319)
1997
22
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
23
Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence. (8017561)
1994
24
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
25
L-tryptophan-induced eosinophilia-myalgia syndrome associated with primary cutaneous malignant fibrous histiocytoma and extraabdominal desmoid tumor. (8402494)
1993
26
Palisading cutaneous fibrous histiocytoma. (3029199)
1986
27
Atypical cutaneous fibrous histiocytoma. (3028197)
1986
28
Atypical, cutaneous fibrous histiocytoma with early metastasis. (3012378)
1986
29
Sarcomas--a clinicopathological guide with particular reference to cutaneous manifestation. I. Dermatofibrosarcoma protuberans, malignant fibrous histiocytoma and the epithelioid sarcoma of Enzinger. (6091955)
1984

Genetic Variations for Cutaneous Fibrous Histiocytoma

Expression for genes affiliated with Cutaneous Fibrous Histiocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous Fibrous Histiocytoma

Search GEO for disease gene expression data for Cutaneous Fibrous Histiocytoma.

Pathways for genes affiliated with Cutaneous Fibrous Histiocytoma

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DES, VIM

Compounds for genes affiliated with Cutaneous Fibrous Histiocytoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1orcein4510.0DES, VIM
2toluidine459.9DES, VIM
3mucicarmine459.8VIM, DES
4gemfibrozil45 29 1111.7DES, VIM
5s 100459.7DES, F13A1, VIM
6b 723459.6VIM, F13A1, DES
7procollagen459.6VIM, F13A1, DES
8phalloidin459.6DES, VIM
9heparin45 29 11 2412.6B3GAT1, DES, F13A1
10fluorochrome459.5VIM, CD34
11heparan sulfate45 2410.5B3GAT1, DES, VIM
12silver459.5F13A1, DES, CD34
13percoll459.3CD34, DES
14reticulin459.2CD34, DES, F13A1, VIM
15hematoxylin459.1VIM, F13A1, DES, CD34
16estrogen458.7B3GAT1, CD34, DES, F13A1, VIM
1712-o-tetradecanoylphorbol 13-acetate458.6MMP11, CD34, DES, VIM
18vegf458.2MMP11, CD34, DES, F13A1, VIM
19progesterone45 60 29 11 2412.0MMP11, B3GAT1, CD34, DES, F13A1, VIM
20paraffin457.7VIM, F13A1, DES, CD68, CD34, MMP11

GO Terms for genes affiliated with Cutaneous Fibrous Histiocytoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.7DES, VIM

Products for genes affiliated with Cutaneous Fibrous Histiocytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Fibrous Histiocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet