MCID: CTN004
MIFTS: 39

Cutaneous Fibrous Histiocytoma malady

Skin diseases, Cancer diseases categories

Summaries for Cutaneous Fibrous Histiocytoma

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32MalaCards
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MalaCards: Cutaneous Fibrous Histiocytoma, also known as dermatofibroma, is related to fibrous histiocytoma and dermatofibrosarcoma. An important gene associated with Cutaneous Fibrous Histiocytoma is LYZ (lysozyme), and among its related pathways is Aurora B signaling. The compounds orcein and toluidine have been mentioned in the context of this disorder. Affiliated tissues include skin and monocytes.

Aliases & Classifications for Cutaneous Fibrous Histiocytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

cutaneous fibrous histiocytoma 8 10 60
dermatofibroma 8 42 44
fibrohistiocytic tumor 8 60
benign cutaneous fibrous histiocytoma 8
dermatofibroma, no icd-o subtype 8
fibrous histiocytoma of skin 8
histiocytoma, benign fibrous 60
sclerosing angioma of skin 8
fibrohistiocytic neoplasm 8
fibrous xanthoma of skin 8
pleomorphic fibroma 8
sclerosing angioma 8
dermatofibroma nos 8


Related Diseases for Cutaneous Fibrous Histiocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma31.1VIM, F13A1, DES, CD34
2dermatofibrosarcoma30.3FOXO4
3basal cell carcinoma30.2MMP11, CD34, F13A1
4melanoma30.1VIM, FOXO4, F13A1, DES, CD68, CD34
5liposarcoma30.1VIM, DES, CD34
6malignant fibroxanthoma30.0VIM, F13A1, DES, CD68
7sarcoma30.0VIM, F13A1, DES, CD34, B3GAT1, MMP11
8epithelioid sarcoma29.8VIM, CD34
9spindle cell sarcoma29.8VIM, DES
10leukemia29.8LYZ, B3GAT1, CD34
11granular cell tumor29.8CD68, DES, VIM
12hemangiopericytoma29.8VIM, F13A1, DES, CD34
13histiocytoma10.8
14malignant skin fibrous histiocytoma10.4
15atypical lipomatous tumor10.2
16sclerosing hemangioma10.2
17pleomorphic liposarcoma10.1
18clear cell acanthoma10.0
19skin sarcoma10.0
20arthritis10.0LYZ
21eye disease10.0LYZ
22metanephric adenoma10.0B3GAT1
23ossifying fibromyxoid tumor10.0B3GAT1
24hepatitis10.0HAVCR1
25germ cell cancer10.0B3GAT1
26sarcoidosis10.0LYZ
27meningitis10.0LYZ
28dermatitis10.0F13A1
29pulmonary embolism10.0F13A1
30adenomatoid tumor10.0VIM
31hypersensitivity reaction type ii disease10.0LYZ, CD68
32multicentric reticulohistiocytosis10.0CD68, HAVCR1
33vascular cancer10.0CD34
34myoepithelioma10.0VIM
35infantile myofibromatosis10.0DES
36adenoma10.0B3GAT1, MMP11
37letterer-siwe disease10.0F13A1, CD68
38atherosclerosis10.0CD68, F13A1
39histiocytosis10.0LYZ, CD68, HAVCR1
40hemangioendothelioma10.0CD34
41myeloid sarcoma10.0CD34, LYZ
42human immunodeficiency virus infectious disease10.0CD34, B3GAT1
43acute leukemia10.0CD34, FOXO4
44perineurioma10.0CD34, VIM
45angiosarcoma10.0CD34, VIM
46epidermolysis bullosa simplex10.0DES
47glomus tumor10.0VIM, DES
48epithelioid leiomyosarcoma10.0DES, VIM
49mesenchymal chondrosarcoma10.0DES, VIM
50angiomyolipoma10.0DES, VIM

Graphical network of the top 20 diseases related to Cutaneous Fibrous Histiocytoma:



Diseases related to cutaneous fibrous histiocytoma

Clinical Features for Cutaneous Fibrous Histiocytoma

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Drugs & Therapeutics for Cutaneous Fibrous Histiocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Cutaneous Fibrous Histiocytoma

Genetic Tests for Cutaneous Fibrous Histiocytoma

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Anatomical Context for Cutaneous Fibrous Histiocytoma

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32MalaCards
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MalaCards organs/tissues related to Cutaneous Fibrous Histiocytoma:

32
Skin, Monocytes

Animal Models for Cutaneous Fibrous Histiocytoma or affiliated genes

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Publications for Cutaneous Fibrous Histiocytoma

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50PubMed
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Articles related to Cutaneous Fibrous Histiocytoma:

(show all 29)
idTitleAuthorsYear
1
Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. (23426120)
2013
2
A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases. (23347814)
2013
3
Cutaneous inflammatory malignant fibrous histiocytoma presenting with a leukemoid reaction: a case report and review of the literature. (22844297)
2012
4
Management of unusual cutaneous malignancies: atypical fibroxanthoma, malignant fibrous histiocytoma, sebaceous carcinoma, extramammary Paget disease. (21421146)
2011
5
Atypical cutaneous fibrous histiocytoma: an unusual and misleading variant of fibrous histiocytoma. (22937387)
2011
6
Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma. (18435726)
2009
7
Recurrent cutaneous malignant fibrous histiocytoma. (19264583)
2009
8
A study of monocytic and dendritic cell markers in benign cutaneous fibrous histiocytoma (dermatofibroma). (18462367)
2008
9
A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma". (18474466)
2008
10
Cutaneous balloon cell dermatofibroma (fibrous histiocytoma). (17414448)
2007
11
Cutaneous malignant fibrous histiocytoma in an HIV-positive patient. (17207179)
2007
12
Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly. (16434321)
2006
13
Report of an angiosarcoma mimic: cutaneous aneurysmal fibrous histiocytoma. (17004978)
2006
14
Cutaneous malignant fibrous histiocytoma of the scalp in a renal transplant recipient. (16403118)
2006
15
Primary cutaneous malignant fibrous histiocytoma: a case report. (16810139)
2006
16
Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. (16008697)
2005
17
The value of immunohistochemistry in atypical cutaneous fibrous histiocytoma. (15365367)
2004
18
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). (12139632)
2002
19
Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma. (10461644)
1999
20
Recurring atypical ("pseudosarcomatous") cutaneous fibrous histiocytoma. (9649666)
1998
21
Cutaneous fibrous histiocytoma. (9158319)
1997
22
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
23
Cellular benign fibrous histiocytoma. Clinicopathologic analysis of 74 cases of a distinctive variant of cutaneous fibrous histiocytoma with frequent recurrence. (8017561)
1994
24
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
25
L-tryptophan-induced eosinophilia-myalgia syndrome associated with primary cutaneous malignant fibrous histiocytoma and extraabdominal desmoid tumor. (8402494)
1993
26
Palisading cutaneous fibrous histiocytoma. (3029199)
1986
27
Atypical cutaneous fibrous histiocytoma. (3028197)
1986
28
Atypical, cutaneous fibrous histiocytoma with early metastasis. (3012378)
1986
29
Sarcomas--a clinicopathological guide with particular reference to cutaneous manifestation. I. Dermatofibrosarcoma protuberans, malignant fibrous histiocytoma and the epithelioid sarcoma of Enzinger. (6091955)
1984

Genetic Variations for Cutaneous Fibrous Histiocytoma

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Expression for genes affiliated with Cutaneous Fibrous Histiocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Fibrous Histiocytoma

Search GEO for disease gene expression data for Cutaneous Fibrous Histiocytoma.

Pathways for genes affiliated with Cutaneous Fibrous Histiocytoma

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37NCBI BioSystems Database
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Pathways related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DES, VIM

Compounds for genes affiliated with Cutaneous Fibrous Histiocytoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1orcein4410.0DES, VIM
2toluidine449.9DES, VIM
3mucicarmine449.8VIM, DES
4gemfibrozil44 28 1111.7DES, VIM
5s 100449.7DES, F13A1, VIM
6b 723449.6VIM, F13A1, DES
7procollagen449.6VIM, F13A1, DES
8phalloidin449.6DES, VIM
9heparin44 28 11 2412.6B3GAT1, DES, F13A1
10fluorochrome449.5VIM, CD34
11heparan sulfate44 2410.5B3GAT1, DES, VIM
12silver449.5F13A1, DES, CD34
13percoll449.3CD34, DES
14reticulin449.2CD34, DES, F13A1, VIM
15hematoxylin449.1VIM, F13A1, DES, CD34
16estrogen448.7B3GAT1, CD34, DES, F13A1, VIM
1712-o-tetradecanoylphorbol 13-acetate448.6MMP11, CD34, DES, VIM
18vegf448.2MMP11, CD34, DES, F13A1, VIM
19progesterone44 59 28 11 2412.0MMP11, B3GAT1, CD34, DES, F13A1, VIM
20paraffin447.7VIM, F13A1, DES, CD68, CD34, MMP11

GO Terms for genes affiliated with Cutaneous Fibrous Histiocytoma

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16Gene Ontology
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Biological processes related to Cutaneous Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.7DES, VIM

Products for genes affiliated with Cutaneous Fibrous Histiocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Fibrous Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet