MCID: CTN012
MIFTS: 37

Cutaneous Leiomyosarcoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 29 14 69
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 47 C4484
SNOMED-CT 64 254771006
UMLS 69 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and marfanoid habitus-inguinal hernia-advanced bone age syndrome. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Spinal Cord Injury. The drugs Fentanyl and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lymph node, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.5
2 marfanoid habitus-inguinal hernia-advanced bone age syndrome 10.4 ACTC1 DES
3 telo2-related intellectual disability-neurodevelopmental disorder 10.4 ACTC1 DES
4 punctate palmoplantar keratoderma type 2 10.3 ACTC1 DES
5 liver angiosarcoma 10.3 ACTC1 DES
6 neurofibroma of the esophagus 10.3 ACTC1 DES
7 secondary pulmonary hemosiderosis 10.3 ACTC1 DES
8 splenic manifestation of prolymphocytic leukemia 10.3 ACTC1 DES
9 nervous system benign neoplasm 10.3 DES FH
10 anaplastic plasmacytoma 10.3 ACTC1 GFAP
11 glossodynia 10.2 DES GFAP
12 ischemia 10.2 ACTC1 DES
13 mucinous ovarian cystadenoma 10.2 DES GFAP
14 bladder cancer, childhood 10.1 ACTC1 GFAP
15 plasmodium ovale malaria 10.1 ACTC1 GFAP
16 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 10.1 ACTC1 DES
17 gangliosidosis gm2 10.1 ACTC1 DES
18 lymphocytic hypophysitis 10.1 ACTC1 VIM
19 gastric signet ring cell adenocarcinoma 10.0 ACTC1 VIM
20 iridogoniodysgenesis and skeletal anomalies 10.0 ACTC1 VIM
21 oesophagostomiasis 10.0 ACTC1 DES
22 melanotic medulloblastoma 10.0 DES GFAP
23 lymphangiosarcoma 10.0 ACTC1 VIM
24 fallopian tube germ cell cancer 10.0 ACTC1 VIM
25 infantile scoliosis 10.0 DES VIM
26 lymphocytic infiltrate of jessner 10.0 DES VIM
27 pulmonary venoocclusive disease 10.0 ACTC1 VIM
28 pineal region yolk sac tumor 10.0 DES VIM
29 mannose-binding lectin protein deficiency 10.0 DES VIM
30 cellular ependymoma 10.0 DES VIM
31 group b strep disease in newborns 10.0 ACTC1 VIM
32 small intestine neuroendocrine neoplasm 9.9 DES VIM
33 dense deposit disease 9.9 ACTC1 VIM
34 childhood pleomorphic rhabdomyosarcoma 9.9 DES VIM
35 rectal neoplasm 9.9 DES VIM
36 extraskeletal mesenchymal chondrosarcoma 9.9 DES VIM
37 benign familial neonatal epilepsy 9.9 ACTC1 VIM
38 spondyloepimetaphyseal dysplasia, isidor type 9.9 DES VIM
39 polyosteolysis/hyperostosis syndrome 9.9 ACTC1 VIM
40 myoepithelial carcinoma 9.9 DES VIM
41 basosquamous carcinoma 9.9 GFAP VIM
42 mucin-rich endometrial endometrioid adenocarcinoma 9.9 DES VIM
43 reticular pattern testicular yolk sac tumor 9.9 GFAP VIM
44 pyoderma 9.9 GFAP VIM
45 enamel hypoplasia cataract hydrocephaly 9.9 DES VIM
46 aggressive systemic mastocytosis 9.9 GFAP VIM
47 ganglioglioma 9.8 GFAP VIM
48 axonal neuropathy 9.8 GFAP VIM
49 anaplastic oligodendroglioma 9.8 GFAP VIM
50 behcet's syndrome arthropathy 9.8 GFAP VIM

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 FH GFAP VIM ACTC1 DES
2 homeostasis/metabolism MP:0005376 9.35 ACTC1 DES FH GFAP VIM
3 muscle MP:0005369 8.92 ACTC1 DES GFAP VIM

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Drugs for Cutaneous Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
6 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
7
Doxil Approved June 1999 Phase 2, Phase 3 31703
8 Adjuvants, Anesthesia Phase 3
9 Analgesics Phase 3
10 Analgesics, Opioid Phase 3
11 Anesthetics Phase 3
12 Anesthetics, General Phase 3
13 Anesthetics, Intravenous Phase 3
14 Central Nervous System Depressants Phase 3
15 Liver Extracts Phase 3
16 Narcotics Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Alkylating Agents Phase 2, Phase 3,Phase 1
19 Anti-Bacterial Agents Phase 2, Phase 3
20 Antibiotics, Antitubercular Phase 2, Phase 3
21 Isophosphamide mustard Phase 2, Phase 3
22 Topoisomerase Inhibitors Phase 2, Phase 3
23 Cola Nutraceutical Phase 3
24
nivolumab Approved Phase 1, Phase 2 946414-94-4
25
Trabectedin Approved, Investigational Phase 1, Phase 2 114899-77-3 108150
26 Antibodies Phase 1, Phase 2
27 Antibodies, Blocking Phase 1, Phase 2
28 Antibodies, Monoclonal Phase 1, Phase 2
29 Immunoglobulins Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
3 Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma Recruiting NCT03138161 Phase 1, Phase 2 Trabectedin;Ipilimumab;Nivolumab
4 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Heparin;Minocycline-EDTA

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Genetic tests related to Cutaneous Leiomyosarcoma:

id Genetic test Affiliating Genes
1 Cutaneous Leiomyosarcoma 29

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

39
Skin, Liver, Lymph Node, Smooth Muscle

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 57)
id Title Authors Year
1
Cutaneous Leiomyosarcoma of the Face. ( 28913324 )
2017
2
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome. A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. ( 28475508 )
2017
3
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. ( 28665730 )
2017
4
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. ( 28177971 )
2017
5
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. ( 26787636 )
2016
6
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. ( 26276213 )
2015
7
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. ( 26516329 )
2015
8
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of fumarate hydratase gene. ( 25913776 )
2015
9
Recurrent cutaneous leiomyosarcoma of the inner thigh. ( 25900934 )
2015
10
Cutaneous leiomyosarcoma - Case report. ( 25408738 )
2014
11
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. ( 24077407 )
2013
12
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. ( 23984230 )
2013
13
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. ( 23851868 )
2013
14
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. ( 23293965 )
2013
15
Rapid growing superficial cutaneous leiomyosarcoma of the face. ( 23717020 )
2013
16
Cutaneous leiomyosarcoma arising in a smallpox scar. ( 22799750 )
2012
17
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. ( 22324176 )
2012
18
Superficial cutaneous leiomyosarcoma of the face: report of three cases. ( 21352334 )
2011
19
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. ( 21571171 )
2011
20
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. ( 19780873 )
2011
21
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. ( 22019008 )
2011
22
Cutaneous leiomyosarcoma on the trunk. ( 22147043 )
2011
23
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. ( 20534095 )
2010
24
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. ( 20102404 )
2010
25
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. ( 20579459 )
2010
26
Childhood cutaneous leiomyosarcoma. ( 19689533 )
2009
27
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. ( 19010751 )
2009
28
Cutaneous leiomyosarcoma developing on a pacemaker pocket. ( 19389092 )
2009
29
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. ( 18986479 )
2008
30
Cutaneous leiomyosarcoma in a pigeon. ( 18296669 )
2008
31
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. ( 18429649 )
2008
32
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. ( 17343592 )
2007
33
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. ( 18416331 )
2007
34
Cutaneous leiomyosarcoma: a tumor of the head and neck. ( 17451590 )
2007
35
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. ( 16972950 )
2006
36
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? ( 16634920 )
2006
37
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. ( 16972948 )
2006
38
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. ( 14765271 )
2004
39
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. ( 15491456 )
2004
40
Cutaneous leiomyosarcoma. ( 11884817 )
2002
41
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. ( 11703527 )
2001
42
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. ( 10583188 )
1999
43
Recurrent cutaneous leiomyosarcoma. ( 9646238 )
1998
44
Cutaneous leiomyosarcoma. ( 9298873 )
1997
45
Cutaneous leiomyosarcoma in a child. ( 9263308 )
1997
46
Sclerotic primary cutaneous leiomyosarcoma. ( 8599440 )
1995
47
Cutaneous leiomyosarcoma. ( 1377726 )
1992
48
Recurrent cutaneous leiomyosarcoma. ( 1617597 )
1992
49
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. ( 3294254 )
1988
50
Cutaneous leiomyosarcoma. ( 3439771 )
1987

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.81 ACTC1 DES VIM
2 11.45 GFAP VIM
3 11.22 GFAP VIM
4
Show member pathways
11.17 DES GFAP VIM
5
Show member pathways
10.91 DES VIM
6 10.66 ACTC1 DES VIM

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.96 DES GFAP
2 cell body GO:0044297 8.85 ACTC1
3 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
2 negative regulation of neuron projection development GO:0010977 9.07 VIM
3 astrocyte development GO:0014002 9.02 VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 VIM
5 intermediate filament-based process GO:0045103 8.85 VIM
6 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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