MCID: CTN012
MIFTS: 33

Cutaneous Leiomyosarcoma malady

Skin category

Summaries for Cutaneous Leiomyosarcoma

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33MalaCards
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MalaCards: Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to epithelioid leiomyosarcoma and myxoid leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Aurora B signaling. The compounds aspartate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, smooth muscle and skin, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Cutaneous Leiomyosarcoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

cutaneous leiomyosarcoma 8 61
leiomyosarcoma of the skin 8


External Ids:

Disease Ontology8 DOID:5273
SNOMED-CT57 254771006
NCIt40 C4484

Related Diseases for Cutaneous Leiomyosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma30.4VIM, DES, ACTC1
2myxoid leiomyosarcoma10.2
3granular cell leiomyosarcoma10.1
4cutaneous liposarcoma10.0
5syringocystadenoma papilliferum10.0
6myxoid liposarcoma10.0
7smallpox10.0
8fasciitis10.0ACTC1
9hemangioma10.0ACTC1
10papilloma10.0ACTC1
11histiocytosis10.0S100B
12leiomyomatosis10.0FH
13infantile myofibromatosis10.0DES
14bladder carcinoma10.0FH
15lymphangioleiomyomatosis10.0DES
16pheochromocytoma10.0FH
17endometriosis10.0ACTC1
18adenomatoid tumor10.0VIM
19juvenile xanthogranuloma10.0S100B
20lipoma10.0DES
21uterine carcinosarcoma10.0KIT
22carney triad10.0KIT
23mastocytosis10.0KIT
24seminoma10.0KIT
25sertoli-leydig cell tumor10.0MUC1
26epidermolysis bullosa simplex10.0DES
27cystadenocarcinoma10.0MUC1
28colorectal cancer10.0MUC1
29adenosarcoma10.0ACTC1, DES
30myoma10.0FH
31teratoma10.0KIT, ACTC1
32liposarcoma10.0VIM, DES
33hidradenoma10.0MUC1
34tuberous sclerosis10.0S100B, VIM
35embryonal rhabdomyosarcoma10.0DES, ACTC1
36alveolar soft part sarcoma10.0DES, VIM
37ganglioglioma10.0S100B
38clear cell sarcoma10.0S100B, KIT
39syringoma10.0MUC1, S100B
40adenoma10.0ACTC1, MUC1
41fibrous meningioma10.0MUC1, S100B
42hemangioblastoma10.0S100B, MUC1
43dedifferentiated liposarcoma10.0DES, KIT
44malignant mixed mullerian tumor10.0KIT, VIM
45phyllode tumor10.0KIT, VIM
46myoepithelioma10.0VIM, S100B, ACTC1
47medulloblastoma10.0DES, S100B, ACTC1
48cutaneous fibrous histiocytoma10.0DES, S100B, ACTC1
49choroid plexus papilloma10.0S100B, MUC1
50anaplastic ependymoma10.0MUC1, S100B

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to cutaneous leiomyosarcoma

Clinical Features for Cutaneous Leiomyosarcoma

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cutaneous Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leiomyosarcoma

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Search CenterWatch for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Anatomical Context for Cutaneous Leiomyosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

33
Lymph node, Smooth muscle, Skin

Animal Models for Cutaneous Leiomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1ACTC1, DES, FH

Publications for Cutaneous Leiomyosarcoma

Sources:
51PubMed
See all sources

Articles related to Cutaneous Leiomyosarcoma:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. (23851868)
2013
2
Phosphohistone-H3 and Ki-67 immunostaining in cutaneous pilar leiomyoma and leiomyosarcoma (atypical intradermal smooth muscle neoplasm). (23550775)
2013
3
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. (23984230)
2013
4
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. (24077407)
2013
5
Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature. (22809451)
2012
6
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
7
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
8
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. (21571171)
2011
9
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. (22019008)
2011
10
Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma". (21358302)
2011
11
Cutaneous leiomyosarcoma on the trunk. (22147043)
2011
12
Epstein-Barr virus-associated leiomyosarcoma with cutaneous involvement in an African child with human immunodeficiency virus: a case report and review of the literature. (21623869)
2011
13
Superficial cutaneous leiomyosarcoma of the face: report of three cases. (21352334)
2011
14
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. (20579459)
2010
15
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
16
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. (20102404)
2010
17
Childhood cutaneous leiomyosarcoma. (19689533)
2009
18
Cutaneous leiomyosarcoma developing on a pacemaker pocket. (19389092)
2009
19
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. (19010751)
2009
20
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. (18986479)
2008
21
Cutaneous leiomyosarcoma in a pigeon. (18296669)
2008
22
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. (18429649)
2008
23
Cutaneous leiomyosarcoma: a tumor of the head and neck. (17451590)
2007
24
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
25
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
26
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
27
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. (16972950)
2006
28
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? (16634920)
2006
29
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
30
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. (14765271)
2004
31
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)
2002
32
Cutaneous leiomyosarcoma. (11884817)
2002
33
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
34
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. (10583188)
1999
35
Recurrent cutaneous leiomyosarcoma. (9646238)
1998
36
Cutaneous leiomyosarcoma. (9298873)
1997
37
Cutaneous leiomyosarcoma in a child. (9263308)
1997
38
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
39
Recurrent cutaneous leiomyosarcoma. (1617597)
1992
40
Cutaneous leiomyosarcoma. (1377726)
1992
41
Intermediate and fine cytofilaments in cutaneous and subcutaneous leiomyosarcomas. (1716444)
1991
42
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
43
Cutaneous leiomyosarcoma. (3439771)
1987
44
Cutaneous leiomyosarcoma: case reports and review of the literature. (3579172)
1987
45
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. (3319853)
1986
46
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. (7296963)
1981
47
Primary cutaneous leiomyosarcoma of the scalp in a child with lymph node metastases. (7272567)
1981
48
Cutaneous leiomyosarcoma in a long-eared bat, Plecotus townsendii virginianus, Handley. (5889797)
1965
49
Cutaneous leiomyosarcoma. (13240050)
1955
50
Cutaneous leiomyosarcoma with lymphatic spread: a report of two cases. (13277862)
1955

Genetic Variations for Cutaneous Leiomyosarcoma

Expression for genes affiliated with Cutaneous Leiomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for genes affiliated with Cutaneous Leiomyosarcoma

Sources:
38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ACTC1, KIT
29.4VIM, DES
3
Hide members
9.1ACTC1, DES, VIM
49.1ACTC1, DES, VIM
5
Hide members
8.0KIT, MUC1, DES, VIM

Compounds for genes affiliated with Cutaneous Leiomyosarcoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1aspartate4510.3FH
2creatinine4510.1ACTC1, FH
3glycogen45 2410.9KIT, ACTC1
42-methoxyethanol459.8ACTC1, VIM
5steroid459.8ACTC1, DES
6monochloroacetic acid459.7KIT, VIM
7glucose459.7ACTC1, MUC1
8fluorochrome459.4KIT, VIM
9bromodeoxyuridine459.3DES, S100B, VIM
10toluidine459.2KIT, DES, VIM
11valine459.1VIM, S100B, KIT
12eosin459.1VIM, S100B, MUC1
13orcein459.1ACTC1, DES, S100B, VIM
14iron45 2410.0VIM, S100B, DES, ACTC1
15progestin459.0MUC1, DES, VIM
16imatinib45 50 1110.9ACTC1, KIT, DES, S100B
17adriamycin458.9VIM, DES, MUC1
18proline458.9VIM, S100B, FH, DES
19pyruvate458.9S100B, FH, MUC1
20dihydrotestosterone45 29 11 2411.9VIM, DES, MUC1
21agarose458.9KIT, MUC1, S100B
22hyaluronic acid45 249.9VIM, DES, MUC1
23cytarabine45 50 1110.9KIT, MUC1, VIM
24gold458.8KIT, MUC1, DES
25methionine458.8VIM, S100B, DES, KIT
26biotin45 11 2410.6VIM, DES, MUC1, ACTC1
27chloramphenicol45 2 1110.6MUC1, S100B, VIM
28methotrexate45 50 1110.5VIM, MUC1, KIT
29cyclic amp45 249.5VIM, S100B, DES, MUC1
30dexamethasone45 50 29 1111.5ACTC1, MUC1, S100B, VIM
31thymidine45 249.4S100B, DES, MUC1, KIT
32actinomycin d458.4KIT, MUC1, DES, VIM
33lactate458.3VIM, S100B, FH, DES, KIT
34s 100458.3ACTC1, MUC1, DES, S100B, VIM
35oxygen45 249.3S100B, FH, DES, MUC1, ACTC1
36reticulin458.3VIM, S100B, DES, MUC1, ACTC1
37mucicarmine458.3ACTC1, MUC1, DES, S100B, VIM
38b 723458.3VIM, S100B, DES, MUC1, ACTC1
39threonine458.1KIT, MUC1, DES, S100B
40cysteine458.0VIM, S100B, DES, MUC1, KIT
41nitric oxide45 11 249.8S100B, DES, MUC1, KIT
42serine457.8VIM, S100B, DES, MUC1, KIT
43tyrosine457.7S100B, FH, DES, MUC1, KIT, ACTC1
44hematoxylin457.7VIM, S100B, DES, MUC1, KIT, ACTC1
45formaldehyde45 248.6VIM, S100B, DES, MUC1, KIT, ACTC1
46paraffin457.6VIM, S100B, DES, MUC1, KIT, ACTC1
47progesterone45 60 29 11 2411.6VIM, S100B, DES, MUC1, KIT, ACTC1
48testosterone45 60 11 2410.6VIM, S100B, DES, MUC1, KIT, ACTC1
49vegf457.6VIM, S100B, DES, MUC1, KIT, ACTC1
50retinoic acid45 248.6VIM, S100B, DES, MUC1, KIT, ACTC1

GO Terms for genes affiliated with Cutaneous Leiomyosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3ACTC1, KIT, MUC1, FH, S100B, VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1ACTC1, DES, VIM

Products for genes affiliated with Cutaneous Leiomyosarcoma

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Sources for Cutaneous Leiomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet