MCID: CTN012
MIFTS: 37

Cutaneous Leiomyosarcoma malady

Skin diseases category

Summaries for Cutaneous Leiomyosarcoma

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32MalaCards
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MalaCards: Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and epithelioid leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Aurora B signaling. The compounds aspartate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include skin, smooth muscle and lymph node, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Cutaneous Leiomyosarcoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

cutaneous leiomyosarcoma 8 60
leiomyosarcoma of the skin 8


External Ids:

Disease Ontology8 DOID:5273
SNOMED-CT56 254771006
NCIt39 C4484

Related Diseases for Cutaneous Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.2ACTC1, KIT, MUC1, DES, FH, S100B
2epithelioid leiomyosarcoma30.3ACTC1, DES, VIM
3liposarcoma30.0DES, VIM
4leiomyoma29.9VIM, S100B, FH, DES, KIT, ACTC1
5myxoid leiomyosarcoma10.1
6granular cell leiomyosarcoma10.1
7cutaneous liposarcoma10.0
8syringocystadenoma papilliferum10.0
9myxoid liposarcoma10.0
10retinoblastoma10.0
11smallpox10.0
12fasciitis10.0ACTC1
13hemangioma10.0ACTC1
14papilloma10.0ACTC1
15histiocytosis10.0S100B
16leiomyomatosis10.0FH
17infantile myofibromatosis10.0DES
18bladder carcinoma10.0FH
19lymphangioleiomyomatosis10.0DES
20pheochromocytoma10.0FH
21endometriosis10.0ACTC1
22adenomatoid tumor10.0VIM
23juvenile xanthogranuloma10.0S100B
24lipoma10.0DES
25uterine carcinosarcoma10.0KIT
26carney triad10.0KIT
27mastocytosis10.0KIT
28seminoma10.0KIT
29sertoli-leydig cell tumor10.0MUC1
30epidermolysis bullosa simplex10.0DES
31cystadenocarcinoma10.0MUC1
32colorectal cancer10.0MUC1
33adenosarcoma10.0DES, ACTC1
34myoma10.0FH
35teratoma10.0KIT, ACTC1
36hidradenoma10.0MUC1
37tuberous sclerosis10.0S100B, VIM
38embryonal rhabdomyosarcoma10.0ACTC1, DES
39alveolar soft part sarcoma10.0VIM, DES
40ganglioglioma10.0S100B
41clear cell sarcoma10.0KIT, S100B
42syringoma10.0MUC1, S100B
43adenoma10.0ACTC1, MUC1
44fibrous meningioma10.0MUC1, S100B
45hemangioblastoma10.0MUC1, S100B
46dedifferentiated liposarcoma10.0KIT, DES
47malignant mixed mullerian tumor10.0VIM, KIT
48phyllode tumor10.0KIT, VIM
49myoepithelioma10.0ACTC1, S100B, VIM
50medulloblastoma10.0S100B, DES, ACTC1

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to cutaneous leiomyosarcoma

Clinical Features for Cutaneous Leiomyosarcoma

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Drugs & Therapeutics for Cutaneous Leiomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cutaneous Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leiomyosarcoma

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Search CenterWatch for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

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Anatomical Context for Cutaneous Leiomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

32
Skin, Smooth muscle, Lymph node

Animal Models for Cutaneous Leiomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1ACTC1, DES, FH

Publications for Cutaneous Leiomyosarcoma

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50PubMed
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Articles related to Cutaneous Leiomyosarcoma:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. (23851868)
2013
2
Phosphohistone-H3 and Ki-67 immunostaining in cutaneous pilar leiomyoma and leiomyosarcoma (atypical intradermal smooth muscle neoplasm). (23550775)
2013
3
Rapid growing superficial cutaneous leiomyosarcoma of the face. (23717020)
2013
4
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. (23293965)
2013
5
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. (23984230)
2013
6
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. (24077407)
2013
7
Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature. (22809451)
2012
8
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
9
Cutaneous leiomyosarcoma arising in a smallpox scar. (22799750)
2012
10
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
11
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. (21571171)
2011
12
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. (22019008)
2011
13
Cutaneous leiomyosarcoma on the trunk. (22147043)
2011
14
Epstein-Barr virus-associated leiomyosarcoma with cutaneous involvement in an African child with human immunodeficiency virus: a case report and review of the literature. (21623869)
2011
15
Superficial cutaneous leiomyosarcoma of the face: report of three cases. (21352334)
2011
16
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. (20579459)
2010
17
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
18
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. (20102404)
2010
19
Cutaneous leiomyosarcoma developing on a pacemaker pocket. (19389092)
2009
20
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. (19010751)
2009
21
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. (18986479)
2008
22
Cutaneous leiomyosarcoma in a pigeon. (18296669)
2008
23
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. (18429649)
2008
24
Cutaneous leiomyosarcoma: a tumor of the head and neck. (17451590)
2007
25
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
26
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
27
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
28
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. (16972950)
2006
29
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? (16634920)
2006
30
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
31
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. (14765271)
2004
32
Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas. (12177782)
2002
33
Cutaneous leiomyosarcoma. (11884817)
2002
34
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
35
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. (10583188)
1999
36
Cutaneous leiomyosarcoma. (9298873)
1997
37
Cutaneous leiomyosarcoma in a child. (9263308)
1997
38
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
39
Recurrent cutaneous leiomyosarcoma. (1617597)
1992
40
Cutaneous leiomyosarcoma. (1377726)
1992
41
Intermediate and fine cytofilaments in cutaneous and subcutaneous leiomyosarcomas. (1716444)
1991
42
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
43
Cutaneous leiomyosarcoma. (3439771)
1987
44
Cutaneous leiomyosarcoma: case reports and review of the literature. (3579172)
1987
45
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. (3319853)
1986
46
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. (7296963)
1981
47
Primary cutaneous leiomyosarcoma of the scalp in a child with lymph node metastases. (7272567)
1981
48
Cutaneous leiomyosarcoma in a long-eared bat, Plecotus townsendii virginianus, Handley. (5889797)
1965
49
Cutaneous leiomyosarcoma. (13240050)
1955
50
Cutaneous leiomyosarcoma with lymphatic spread: a report of two cases. (13277862)
1955

Genetic Variations for Cutaneous Leiomyosarcoma

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Expression for genes affiliated with Cutaneous Leiomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for genes affiliated with Cutaneous Leiomyosarcoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ACTC1, KIT
29.4VIM, DES
3
Hide members
9.1ACTC1, DES, VIM
49.1ACTC1, DES, VIM
5
Hide members
8.0KIT, MUC1, DES, VIM

Compounds for genes affiliated with Cutaneous Leiomyosarcoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1aspartate4410.3FH
2creatinine4410.1FH, ACTC1
3glycogen44 2410.9ACTC1, KIT
42-methoxyethanol449.8VIM, ACTC1
5steroid449.8ACTC1, DES
6monochloroacetic acid449.7KIT, VIM
7glucose449.7MUC1, ACTC1
8fluorochrome449.4VIM, KIT
9bromodeoxyuridine449.3DES, S100B, VIM
10toluidine449.2VIM, KIT, DES
11valine449.1VIM, KIT, S100B
12eosin449.1MUC1, S100B, VIM
13orcein449.1S100B, ACTC1, VIM, DES
14iron44 2410.0S100B, DES, ACTC1, VIM
15progestin449.0VIM, DES, MUC1
16imatinib44 49 1110.9S100B, DES, KIT, ACTC1
17adriamycin448.9MUC1, DES, VIM
18proline448.9S100B, FH, DES, VIM
19pyruvate448.9FH, MUC1, S100B
20dihydrotestosterone44 28 11 2411.9MUC1, VIM, DES
21agarose448.9S100B, MUC1, KIT
22hyaluronic acid44 249.9MUC1, DES, VIM
23cytarabine44 49 1110.9MUC1, VIM, KIT
24gold448.8MUC1, DES, KIT
25methionine448.8DES, S100B, VIM, KIT
26biotin44 11 2410.6VIM, DES, ACTC1, MUC1
27chloramphenicol44 2 1110.6S100B, VIM, MUC1
28methotrexate44 49 1110.5VIM, MUC1, KIT
29cyclic amp44 249.5S100B, MUC1, VIM, DES
30dexamethasone44 49 28 1111.5ACTC1, MUC1, S100B, VIM
31thymidine44 249.4S100B, DES, MUC1, KIT
32actinomycin d448.4MUC1, KIT, DES, VIM
33lactate448.3VIM, KIT, DES, S100B, FH
34s 100448.3S100B, ACTC1, MUC1, DES, VIM
35oxygen44 249.3MUC1, FH, S100B, ACTC1, DES
36reticulin448.3S100B, ACTC1, MUC1, DES, VIM
37mucicarmine448.3S100B, MUC1, ACTC1, DES, VIM
38b 723448.3S100B, ACTC1, MUC1, DES, VIM
39threonine448.1KIT, DES, S100B, MUC1
40cysteine448.0KIT, VIM, MUC1, DES, S100B
41nitric oxide44 11 249.8S100B, KIT, MUC1, DES
42serine447.8DES, MUC1, KIT, VIM, S100B
43tyrosine447.7DES, ACTC1, KIT, FH, MUC1, S100B
44hematoxylin447.7S100B, DES, MUC1, VIM, KIT, ACTC1
45formaldehyde44 248.6KIT, DES, VIM, ACTC1, S100B, MUC1
46paraffin447.6DES, S100B, VIM, MUC1, KIT, ACTC1
47progesterone44 59 28 11 2411.6ACTC1, KIT, MUC1, DES, VIM, S100B
48testosterone44 59 11 2410.6ACTC1, S100B, VIM, DES, MUC1, KIT
49vegf447.6ACTC1, KIT, MUC1, S100B, VIM, DES
50retinoic acid44 248.6S100B, KIT, VIM, ACTC1, MUC1, DES

GO Terms for genes affiliated with Cutaneous Leiomyosarcoma

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16Gene Ontology
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Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3ACTC1, KIT, MUC1, FH, S100B, VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.1ACTC1, DES, VIM

Products for genes affiliated with Cutaneous Leiomyosarcoma

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Sources for Cutaneous Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet