MCID: CTN012
MIFTS: 42

Cutaneous Leiomyosarcoma malady

Cancer diseases, Skin diseases categories
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Summaries for Cutaneous Leiomyosarcoma

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MalaCards based summary: Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to epithelioid leiomyosarcoma and liposarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (fumarate hydratase), and among its related pathways are Aurora B signaling and Cardiac Progenitor Differentiation. The compounds 2-methoxyethanol and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and smooth muscle, and related mouse phenotypes are normal and muscle.

Aliases & Classifications for Cutaneous Leiomyosarcoma

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Cutaneous Leiomyosarcoma, Aliases & Descriptions:

Name: Cutaneous Leiomyosarcoma 8 62
 
Leiomyosarcoma of the Skin 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:5273
SNOMED-CT57 254771006
NCIt39 C4484

Related Diseases for Cutaneous Leiomyosarcoma

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Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma30.5DES, VIM, ACTC1
2liposarcoma30.4VIM, DES
3leiomyosarcoma29.9KIT, S100B, FH, ACTC1, MUC1, VIM
4leiomyoma29.1DES, VIM, ACTC1, FH, S100B, KIT
5fasciitis10.5ACTC1
6leiomyomatosis10.5FH
7infantile myofibromatosis10.4DES
8adenomatoid tumor10.4VIM
9juvenile xanthogranuloma10.4S100B
10histiocytosis10.4S100B
11ganglioglioma10.4S100B
12hidradenoma10.4MUC1
13hemangioma10.3ACTC1
14cystadenocarcinoma10.3MUC1
15carney triad10.3KIT
16papilloma10.3ACTC1
17adenosarcoma10.3DES, ACTC1
18syringoma10.2S100B, MUC1
19fibrous meningioma10.2S100B, MUC1
20embryonal rhabdomyosarcoma10.2DES, ACTC1
21alveolar soft part sarcoma10.2DES, VIM
22choroid plexus papilloma10.2MUC1, S100B
23anaplastic ependymoma10.2MUC1, S100B
24granular cell leiomyosarcoma10.2
25clear cell ependymoma10.2VIM, MUC1
26desmoplastic small round cell tumor10.1MUC1, DES
27uterine fibroid10.1FH, DES
28tubular adenocarcinoma10.1ACTC1, MUC1
29hemangioblastoma10.1MUC1, S100B
30epithelioid sarcoma10.1VIM, MUC1
31mucoepidermoid carcinoma10.1MUC1, ACTC1
32secretory meningioma10.1VIM, MUC1
33tuberous sclerosis10.1S100B, VIM
34clear cell sarcoma10.1S100B, KIT
35cutaneous fibrous histiocytoma10.1S100B, ACTC1, DES
36dedifferentiated liposarcoma10.1DES, KIT
37myoepithelioma10.1VIM, ACTC1, S100B
38malignant mixed mullerian tumor10.1VIM, KIT
39myxoid liposarcoma10.1
40retinoblastoma10.1
41smallpox10.1
42phyllode tumor10.0VIM, KIT
43uterine sarcoma10.0DES, KIT
44pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
45fibroma10.0ACTC1, VIM, DES
46medulloblastoma10.0S100B, ACTC1, DES
47carcinoid syndrome10.0ACTC1, MUC1
48granular cell tumor10.0DES, VIM, S100B
49teratoma10.0ACTC1, KIT
50wilms tumor10.0ACTC1, VIM, DES

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to cutaneous leiomyosarcoma

Symptoms for Cutaneous Leiomyosarcoma

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Drugs & Therapeutics for Cutaneous Leiomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Cutaneous Leiomyosarcoma

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

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Anatomical Context for Cutaneous Leiomyosarcoma

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MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

32
Skin, Lymph node, Smooth muscle

Animal Models for Cutaneous Leiomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2KIT, S100B, ACTC1, MUC1
2MP:00053697.9DES, VIM, ACTC1, KIT
3MP:00053767.1KIT, FH, ACTC1, MUC1, VIM, DES

Publications for Cutaneous Leiomyosarcoma

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Articles related to Cutaneous Leiomyosarcoma:

(show all 47)
idTitleAuthorsYear
1
Cutaneous leiomyosarcoma - Case report. (25408738)
2014
2
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. (23851868)
2013
3
Rapid growing superficial cutaneous leiomyosarcoma of the face. (23717020)
2013
4
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. (23293965)
2013
5
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. (23984230)
2013
6
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. (24077407)
2013
7
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
8
Cutaneous leiomyosarcoma arising in a smallpox scar. (22799750)
2012
9
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
10
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. (21571171)
2011
11
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. (22019008)
2011
12
Cutaneous leiomyosarcoma on the trunk. (22147043)
2011
13
Superficial cutaneous leiomyosarcoma of the face: report of three cases. (21352334)
2011
14
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. (20579459)
2010
15
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
16
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. (20102404)
2010
17
Childhood cutaneous leiomyosarcoma. (19689533)
2009
18
Cutaneous leiomyosarcoma developing on a pacemaker pocket. (19389092)
2009
19
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. (19010751)
2009
20
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. (18986479)
2008
21
Cutaneous leiomyosarcoma in a pigeon. (18296669)
2008
22
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. (18429649)
2008
23
Cutaneous leiomyosarcoma: a tumor of the head and neck. (17451590)
2007
24
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
25
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
26
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. (16972950)
2006
27
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? (16634920)
2006
28
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
29
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. (14765271)
2004
30
Cutaneous leiomyosarcoma. (11884817)
2002
31
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
32
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. (10583188)
1999
33
Recurrent cutaneous leiomyosarcoma. (9646238)
1998
34
Cutaneous leiomyosarcoma. (9298873)
1997
35
Cutaneous leiomyosarcoma in a child. (9263308)
1997
36
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
37
Recurrent cutaneous leiomyosarcoma. (1617597)
1992
38
Cutaneous leiomyosarcoma. (1377726)
1992
39
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
40
Cutaneous leiomyosarcoma. (3439771)
1987
41
Cutaneous leiomyosarcoma: case reports and review of the literature. (3579172)
1987
42
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. (3319853)
1986
43
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. (7296963)
1981
44
Primary cutaneous leiomyosarcoma of the scalp in a child with lymph node metastases. (7272567)
1981
45
Cutaneous leiomyosarcoma in a long-eared bat, Plecotus townsendii virginianus, Handley. (5889797)
1965
46
Cutaneous leiomyosarcoma. (13240050)
1955
47
Cutaneous leiomyosarcoma with lymphatic spread: a report of two cases. (13277862)
1955

Variations for Cutaneous Leiomyosarcoma

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Expression for genes affiliated with Cutaneous Leiomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for genes affiliated with Cutaneous Leiomyosarcoma

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Pathways related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.4VIM, DES
29.2KIT, ACTC1
39.0ACTC1, VIM, DES
4
Show member pathways
9.0ACTC1, VIM, DES
5
Show member pathways
8.0DES, VIM, MUC1, KIT

Compounds for genes affiliated with Cutaneous Leiomyosarcoma

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Compounds related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.7VIM, ACTC1
2monochloroacetic acid449.5KIT, VIM
3procollagen449.4ACTC1, VIM, DES
4eosin449.3S100B, MUC1, VIM
5bromodeoxyuridine449.2VIM, S100B, DES
6progestin449.2MUC1, VIM, DES
7adriamycin449.1MUC1, VIM, DES
8dihydrotestosterone44 28 24 1112.1DES, VIM, MUC1
9pyruvate449.0S100B, FH, MUC1
10hyaluronic acid44 2410.0VIM, DES, MUC1
11toluidine449.0KIT, VIM, DES
12orcein449.0VIM, ACTC1, S100B, DES
13proline449.0S100B, FH, VIM, DES
14iron44 249.9DES, VIM, ACTC1, S100B
15cytarabine44 50 1110.8KIT, MUC1, VIM
16agarose448.8S100B, KIT, MUC1
17biotin44 24 1110.8ACTC1, VIM, MUC1, DES
18gold448.8MUC1, KIT, DES
19valine448.7S100B, KIT, VIM
20imatinib44 50 1110.7S100B, DES, ACTC1, KIT
21cyclic amp44 249.7S100B, MUC1, VIM, DES
22aspartate448.6FH, KIT, S100B, VIM
23dexamethasone44 50 28 1111.6S100B, ACTC1, MUC1, VIM
24methionine448.5VIM, KIT, DES, S100B
25methotrexate50 44 1110.5MUC1, KIT, VIM
26oxygen44 249.5DES, FH, S100B, ACTC1, MUC1
27steroid448.4DES, S100B, KIT, ACTC1
28s 100448.4MUC1, ACTC1, VIM, DES, S100B
29reticulin448.4ACTC1, VIM, DES, MUC1, S100B
30mucicarmine448.4S100B, ACTC1, MUC1, VIM, DES
31b 723448.4S100B, ACTC1, MUC1, VIM, DES
32thymidine44 249.4DES, S100B, MUC1, KIT
33actinomycin d448.4VIM, KIT, MUC1, DES
34lactate448.2FH, S100B, VIM, DES, KIT
35creatinine448.0DES, S100B, FH, ACTC1, MUC1, VIM
36nitric oxide44 24 1110.0DES, MUC1, KIT, S100B
37cysteine447.9DES, VIM, MUC1, S100B, KIT
38threonine447.8KIT, S100B, MUC1, DES
39serine447.8S100B, MUC1, DES, VIM, KIT
40glucose447.7FH, ACTC1, MUC1, S100B, KIT, DES
41tyrosine447.7KIT, S100B, FH, ACTC1, DES, MUC1
42hematoxylin447.6MUC1, VIM, S100B, KIT, DES, ACTC1
43formaldehyde44 248.6S100B, ACTC1, MUC1, VIM, DES, KIT
44glycogen44 248.6KIT, ACTC1, MUC1, VIM, DES, S100B
45paraffin447.6ACTC1, DES, VIM, MUC1, S100B, KIT
46progesterone44 28 61 24 1111.5KIT, S100B, ACTC1, MUC1, VIM, DES
47testosterone44 61 24 1110.5ACTC1, KIT, S100B, DES, VIM, MUC1
48vegf447.5KIT, DES, S100B, ACTC1, MUC1, VIM
49estrogen447.5KIT, DES, MUC1, ACTC1, S100B, VIM
50retinoic acid44 248.5S100B, KIT, ACTC1, MUC1, VIM, DES

GO Terms for genes affiliated with Cutaneous Leiomyosarcoma

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Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.5FH, ACTC1, MUC1, VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, VIM, DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.4VIM, DES
2identical protein bindingGO:0428028.7S100B, VIM, DES

Products for genes affiliated with Cutaneous Leiomyosarcoma

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Sources for Cutaneous Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet