MCID: CTN012
MIFTS: 33

Cutaneous Leiomyosarcoma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

MalaCards integrated aliases for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 28 14 69
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 46 C4484
SNOMED-CT 64 254771006
UMLS 69 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and leiomyoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Spinal Cord Injury. Affiliated tissues include skin, lymph node and smooth muscle, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 29.7 ACTC1 DES FH VIM
2 leiomyoma 29.2 ACTC1 DES FH
3 liposarcoma 29.0 DES VIM
4 dermatofibrosarcoma protuberans 28.9 ACTC1 DES VIM
5 syringocystadenoma papilliferum 28.3 ACTC1 DES GFAP VIM
6 ovarian fibrothecoma 10.2 ACTC1 DES
7 fibroblastic rheumatism 10.2 ACTC1 DES
8 pulmonary vein stenosis 10.2 ACTC1 DES
9 cystic nephroma 10.2 ACTC1 DES
10 ischemic fasciitis 10.2 ACTC1 DES
11 dedifferentiated liposarcoma 10.2 ACTC1 DES
12 non-langerhans-cell histiocytosis 10.1 ACTC1 DES
13 ovarian benign neoplasm 10.1 DES FH
14 anaplastic ganglioglioma 10.1 ACTC1 GFAP
15 botryoid rhabdomyosarcoma 10.1 ACTC1 DES
16 gliomatosis peritonei 10.1 DES GFAP
17 spindle cell rhabdomyosarcoma 10.1 DES GFAP
18 binswanger's disease 10.1 ACTC1 GFAP
19 angiomyolipoma 10.1 ACTC1 DES
20 necrotizing sialometaplasia 10.1 ACTC1 GFAP
21 familial isolated dilated cardiomyopathy 10.1 ACTC1 DES
22 restrictive cardiomyopathy 10.0 ACTC1 DES
23 lymphangiectasis 10.0 ACTC1 VIM
24 medullomyoblastoma 10.0 DES GFAP
25 glomangiomyoma 10.0 ACTC1 VIM
26 intravascular papillary endothelial hyperplasia 10.0 ACTC1 VIM
27 adenofibroma 10.0 ACTC1 VIM
28 skin glomus tumor 9.9 DES VIM
29 infantile digital fibromatosis 9.9 DES VIM
30 lymphangiomatosis 9.9 DES VIM
31 spiradenoma 9.9 ACTC1 VIM
32 epulis 9.9 DES VIM
33 biphasic synovial sarcoma 9.9 DES VIM
34 teratoma 9.9 ACTC1 GFAP
35 dendritic cell tumor 9.9 ACTC1 VIM
36 granulosa cell tumor of the ovary 9.9 ACTC1 VIM
37 juvenile xanthogranuloma 9.9 DES VIM
38 polymorphous low-grade adenocarcinoma 9.9 ACTC1 VIM
39 mesenchymal chondrosarcoma 9.9 DES VIM
40 extraskeletal ewing sarcoma 9.9 DES VIM
41 congenital epulis 9.9 DES VIM
42 embryonal sarcoma 9.9 DES VIM
43 rhabdoid meningioma 9.9 GFAP VIM
44 chordoid meningioma 9.8 GFAP VIM
45 clear cell meningioma 9.8 GFAP VIM
46 benign mesothelioma 9.8 DES VIM
47 ependymoblastoma 9.8 GFAP VIM
48 myxopapillary ependymoma 9.8 GFAP VIM
49 astroblastoma 9.8 GFAP VIM
50 melanotic neuroectodermal tumor 9.8 GFAP VIM

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 VIM ACTC1 DES FH GFAP
2 homeostasis/metabolism MP:0005376 9.35 VIM ACTC1 DES FH GFAP
3 muscle MP:0005369 8.92 ACTC1 DES GFAP VIM

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Genetic tests related to Cutaneous Leiomyosarcoma:

# Genetic test Affiliating Genes
1 Cutaneous Leiomyosarcoma 28

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

38
Skin, Lymph Node, Smooth Muscle

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 58)
# Title Authors Year
1
Cutaneous Leiomyosarcoma of the Face. ( 28913324 )
2017
2
Cutaneous Leiomyosarcoma: On the Importance of Histologic Location. ( 29233527 )
2017
3
Cutaneous Leiomyosarcoma with Multiple Visceral Metastases in a Domestic Pigeon. ( 28665730 )
2017
4
Cutaneous Leiomyosarcoma: The Clinical Experience of Taipei Veterans General Hospital Revisited. ( 28177971 )
2017
5
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome. A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. ( 28475508 )
2017
6
Clinical and Histopathologic Findings of Cutaneous Leiomyosarcoma: Correlation with Prognosis in 12 Patients. ( 29100621 )
2017
7
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. ( 26787636 )
2016
8
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of fumarate hydratase gene. ( 25913776 )
2015
9
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. ( 26276213 )
2015
10
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. ( 26516329 )
2015
11
Recurrent cutaneous leiomyosarcoma of the inner thigh. ( 25900934 )
2015
12
Cutaneous leiomyosarcoma - Case report. ( 25408738 )
2014
13
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. ( 23984230 )
2013
14
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. ( 23851868 )
2013
15
Rapid growing superficial cutaneous leiomyosarcoma of the face. ( 23717020 )
2013
16
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. ( 23293965 )
2013
17
Cutaneous leiomyosarcoma arising in a smallpox scar. ( 22799750 )
2012
18
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. ( 22324176 )
2012
19
Cutaneous leiomyosarcoma on the trunk. ( 22147043 )
2011
20
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. ( 22019008 )
2011
21
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. ( 19780873 )
2011
22
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. ( 21571171 )
2011
23
Superficial cutaneous leiomyosarcoma of the face: report of three cases. ( 21352334 )
2011
24
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. ( 20579459 )
2010
25
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. ( 20534095 )
2010
26
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. ( 20102404 )
2010
27
Cutaneous leiomyosarcoma developing on a pacemaker pocket. ( 19389092 )
2009
28
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. ( 19010751 )
2009
29
Childhood cutaneous leiomyosarcoma. ( 19689533 )
2009
30
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. ( 18429649 )
2008
31
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. ( 18986479 )
2008
32
Cutaneous leiomyosarcoma in a pigeon. ( 18296669 )
2008
33
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. ( 18416331 )
2007
34
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. ( 17343592 )
2007
35
Cutaneous leiomyosarcoma: a tumor of the head and neck. ( 17451590 )
2007
36
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? ( 16634920 )
2006
37
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. ( 16972950 )
2006
38
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. ( 16972948 )
2006
39
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. ( 15491456 )
2004
40
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. ( 14765271 )
2004
41
Cutaneous leiomyosarcoma. ( 11884817 )
2002
42
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. ( 11703527 )
2001
43
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. ( 10583188 )
1999
44
Recurrent cutaneous leiomyosarcoma. ( 9646238 )
1998
45
Cutaneous leiomyosarcoma. ( 9298873 )
1997
46
Cutaneous leiomyosarcoma in a child. ( 9263308 )
1997
47
Sclerotic primary cutaneous leiomyosarcoma. ( 8599440 )
1995
48
Recurrent cutaneous leiomyosarcoma. ( 1617597 )
1992
49
Cutaneous leiomyosarcoma. ( 1377726 )
1992
50
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. ( 3294254 )
1988

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 ACTC1 DES VIM
2 11.48 GFAP VIM
3 11.22 GFAP VIM
4
Show member pathways
11.17 DES GFAP VIM
5
Show member pathways
10.91 DES VIM
6 10.66 ACTC1 DES VIM
7 10.45 DES GFAP VIM

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 ACTC1 GFAP
2 intermediate filament cytoskeleton GO:0045111 8.96 DES GFAP
3 intermediate filament GO:0005882 8.8 DES GFAP VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.37 GFAP VIM
2 astrocyte development GO:0014002 9.32 GFAP VIM
3 Bergmann glial cell differentiation GO:0060020 9.26 GFAP VIM
4 intermediate filament-based process GO:0045103 9.16 GFAP VIM
5 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
6 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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