MCID: CTN012
MIFTS: 33

Cutaneous Leiomyosarcoma malady

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Cutaneous Leiomyosarcoma

Aliases & Descriptions for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 12 29 14 69
Leiomyosarcoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5273
NCIt 47 C4484
SNOMED-CT 64 254771006
UMLS 69 C0346067

Summaries for Cutaneous Leiomyosarcoma

MalaCards based summary : Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and mucinous cystadenocarcinoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Fentanyl and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and smooth muscle.

Related Diseases for Cutaneous Leiomyosarcoma

Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.5
2 mucinous cystadenocarcinoma 10.2 ACTC1 MUC1
3 conjunctival cancer 10.2 ACTC1 MUC1
4 testicular granulosa cell tumor 10.2 ACTC1 MUC1
5 lymphangiosarcoma 10.1 ACTC1 MUC1
6 angiofollicular lymph hyperplasia 10.1 ACTC1 GFAP
7 perinatal necrotizing enterocolitis 10.1 ACTC1 MUC1
8 desmoid tumor 10.1 ACTC1 MUC1
9 popliteal pterygium syndrome, bartsocas-papas type 10.1 ACTC1 MUC1
10 thymoma 10.1 FH MUC1
11 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.1 ACTC1 GFAP
12 myelinoclastic diffuse sclerosis 10.1 GFAP MUC1
13 trombiculiasis 10.1 GFAP MUC1
14 microinvasive cervical squamous cell carcinoma 10.1 GFAP MUC1
15 endometrial stromal sarcoma 10.1 GFAP MUC1
16 porokeratosis 10.1 GFAP MUC1
17 behcet's syndrome arthropathy 10.1 GFAP MUC1
18 sternum cancer 10.1 GFAP MUC1
19 aneurysm of sinus of valsalva 10.1 GFAP MUC1
20 bone dysplasia azouz type 10.1 ACTC1 GFAP
21 plasmodium ovale malaria 10.1 ACTC1 GFAP
22 13q12.3 microdeletion syndrome 10.1 ACTC1 DES
23 oral erosive lichen 10.1 ACTC1 DES
24 carbon monoxide-induced parkinsonism 10.1 ACTC1 DES
25 osteomyelitis 10.0 ACTC1 DES
26 congenital myasthenic syndrome 10.0 ACTC1 DES
27 malignant dermis tumor 10.0 ACTC1 DES
28 urethral cancer 10.0 ACTC1 DES
29 breast squamous cell carcinoma 10.0 GFAP MUC1
30 biemond syndrome 10.0 ACTC1 DES
31 intestinal obstruction 10.0 ACTC1 DES
32 central nervous system hemangioma 10.0 GFAP MUC1
33 male urethral cancer 10.0 ACTC1 DES
34 pustulosis palmaris et plantaris 10.0 ACTC1 DES
35 dyslexia 10.0 ACTC1 DES
36 occlusion precerebral artery 10.0 ACTC1 MUC1
37 invasive malignant thymoma 10.0 DES MUC1
38 house allergic alveolitis 10.0 ACTC1 DES
39 marfanoid hypermobility syndrome 10.0 DES MUC1
40 glomangioma 10.0 ACTC1 DES
41 tanycytic ependymoma 10.0 DES MUC1
42 sensory system cancer 10.0 DES FH
43 tinea favosa 10.0 ACTC1 DES
44 t-cell childhood lymphoblastic lymphoma 10.0 ACTC1 DES
45 atopic dermatitis 10.0 ACTC1 GFAP
46 pilar sheath acanthoma 10.0 ACTC1 DES
47 granular cell leiomyosarcoma 10.0 GFAP MUC1
48 petrous apex meningioma 10.0 DES MUC1
49 polydactyly cleft lip palate psychomotor retardation 10.0 DES MUC1
50 fitz-hugh-curtis syndrome 10.0 ACTC1 DES

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to Cutaneous Leiomyosarcoma

Symptoms & Phenotypes for Cutaneous Leiomyosarcoma

Drugs & Therapeutics for Cutaneous Leiomyosarcoma

Drugs for Cutaneous Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7 pancreatic polypeptide Phase 3
8 Analgesics Phase 3
9 Adjuvants, Anesthesia Phase 3
10 Narcotics Phase 3
11 Analgesics, Opioid Phase 3
12 Anesthetics Phase 3
13 Anesthetics, General Phase 3
14 Anesthetics, Intravenous Phase 3
15 Peripheral Nervous System Agents Phase 3
16 Liver Extracts Phase 3
17 Central Nervous System Depressants Phase 3
18 Alkylating Agents Phase 2, Phase 3,Phase 1
19 Topoisomerase Inhibitors Phase 2, Phase 3
20 Anti-Bacterial Agents Phase 2, Phase 3
21 Isophosphamide mustard Phase 2, Phase 3
22 Antibiotics, Antitubercular Phase 2, Phase 3
23 Antineoplastic Agents, Alkylating Phase 2, Phase 3,Phase 1
24 Cola Nutraceutical Phase 3
25
nivolumab Approved Phase 1, Phase 2 946414-94-4
26
Trabectedin Approved, Investigational Phase 1, Phase 2 114899-77-3 108150
27 Immunoglobulins Phase 1, Phase 2
28 Antibodies, Blocking Phase 1, Phase 2
29 Antibodies, Monoclonal Phase 1, Phase 2
30 Antibodies Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
3 Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma Recruiting NCT03138161 Phase 1, Phase 2
4 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

Genetic tests related to Cutaneous Leiomyosarcoma:

id Genetic test Affiliating Genes
1 Cutaneous Leiomyosarcoma 29

Anatomical Context for Cutaneous Leiomyosarcoma

MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

39
Skin, Lymph Node, Smooth Muscle

Publications for Cutaneous Leiomyosarcoma

Articles related to Cutaneous Leiomyosarcoma:

(show top 50) (show all 54)
id Title Authors Year
1
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome. A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene. ( 28475508 )
2017
2
Giant Cutaneous Leiomyosarcoma Originating From the Abdominal Wall: A Case Report. ( 26787636 )
2016
3
Current approaches to cutaneous sarcomas: Dermatofibrosarcoma protuberans and cutaneous leiomyosarcoma. ( 26276213 )
2015
4
Recurrent cutaneous leiomyosarcoma of the inner thigh. ( 25900934 )
2015
5
Primary Cutaneous Leiomyosarcoma in a Young Patient Previously Misdiagnosed as Pleomorphic Fibroma. ( 26516329 )
2015
6
Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of fumarate hydratase gene. ( 25913776 )
2015
7
Cutaneous leiomyosarcoma - Case report. ( 25408738 )
2014
8
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. ( 23851868 )
2013
9
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. ( 23293965 )
2013
10
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. ( 23984230 )
2013
11
Rapid growing superficial cutaneous leiomyosarcoma of the face. ( 23717020 )
2013
12
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. ( 24077407 )
2013
13
Cutaneous leiomyosarcoma arising in a smallpox scar. ( 22799750 )
2012
14
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. ( 22324176 )
2012
15
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. ( 22019008 )
2011
16
Cutaneous leiomyosarcoma on the trunk. ( 22147043 )
2011
17
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. ( 21571171 )
2011
18
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. ( 19780873 )
2011
19
Superficial cutaneous leiomyosarcoma of the face: report of three cases. ( 21352334 )
2011
20
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. ( 20534095 )
2010
21
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. ( 20102404 )
2010
22
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. ( 20579459 )
2010
23
Childhood cutaneous leiomyosarcoma. ( 19689533 )
2009
24
Cutaneous leiomyosarcoma developing on a pacemaker pocket. ( 19389092 )
2009
25
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. ( 19010751 )
2009
26
Cutaneous leiomyosarcoma in a pigeon. ( 18296669 )
2008
27
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. ( 18986479 )
2008
28
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. ( 18429649 )
2008
29
Cutaneous leiomyosarcoma: a tumor of the head and neck. ( 17451590 )
2007
30
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. ( 17343592 )
2007
31
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. ( 18416331 )
2007
32
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. ( 16972948 )
2006
33
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? ( 16634920 )
2006
34
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. ( 16972950 )
2006
35
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. ( 15491456 )
2004
36
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. ( 14765271 )
2004
37
Cutaneous leiomyosarcoma. ( 11884817 )
2002
38
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. ( 11703527 )
2001
39
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. ( 10583188 )
1999
40
Recurrent cutaneous leiomyosarcoma. ( 9646238 )
1998
41
Cutaneous leiomyosarcoma. ( 9298873 )
1997
42
Cutaneous leiomyosarcoma in a child. ( 9263308 )
1997
43
Sclerotic primary cutaneous leiomyosarcoma. ( 8599440 )
1995
44
Cutaneous leiomyosarcoma. ( 1377726 )
1992
45
Recurrent cutaneous leiomyosarcoma. ( 1617597 )
1992
46
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. ( 3294254 )
1988
47
Cutaneous leiomyosarcoma: case reports and review of the literature. ( 3579172 )
1987
48
Cutaneous leiomyosarcoma. ( 3439771 )
1987
49
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. ( 3319853 )
1986
50
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. ( 7296963 )
1981

Variations for Cutaneous Leiomyosarcoma

Expression for Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for Cutaneous Leiomyosarcoma

Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.28 ACTC1 DES MUC1
2
Show member pathways
11.19 DES GFAP
3 10.81 ACTC1 DES

GO Terms for Cutaneous Leiomyosarcoma

Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 DES GFAP

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES GFAP

Sources for Cutaneous Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....