MCID: CTN012
MIFTS: 35

Cutaneous Leiomyosarcoma malady

Skin diseases category

Aliases & Classifications for Cutaneous Leiomyosarcoma

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Aliases & Descriptions for Cutaneous Leiomyosarcoma:

Name: Cutaneous Leiomyosarcoma 8 61
 
Leiomyosarcoma of the Skin 8


Classifications:



External Ids:

Disease Ontology8 DOID:5273
SNOMED-CT56 254771006
NCIt39 C4484

Summaries for Cutaneous Leiomyosarcoma

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MalaCards based summary: Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to epithelioid leiomyosarcoma and liposarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (fumarate hydratase), and among its related pathways are Aurora B signaling and Cardiac Progenitor Differentiation. The compounds 2-methoxyethanol and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and smooth muscle, and related mouse phenotypes are normal and muscle.

Related Diseases for Cutaneous Leiomyosarcoma

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Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid leiomyosarcoma30.5DES, VIM, ACTC1
2liposarcoma30.4VIM, DES
3leiomyosarcoma29.9KIT, S100B, FH, ACTC1, MUC1, VIM
4leiomyoma29.1DES, VIM, ACTC1, FH, S100B, KIT
5renal cell carcinoma10.5FH
6fasciitis10.5ACTC1
7leiomyomatosis10.4FH
8infantile myofibromatosis10.4DES
9adenomatoid tumor10.4VIM
10juvenile xanthogranuloma10.4S100B
11histiocytosis10.4S100B
12ganglioglioma10.4S100B
13hidradenoma10.4MUC1
14hemangioma10.3ACTC1
15cystadenocarcinoma10.3MUC1
16carney triad10.3KIT
17papilloma10.3ACTC1
18adenosarcoma10.3DES, ACTC1
19syringoma10.2S100B, MUC1
20fibrous meningioma10.2S100B, MUC1
21embryonal rhabdomyosarcoma10.2DES, ACTC1
22alveolar soft-part sarcoma10.2DES, VIM
23choroid plexus papilloma10.2MUC1, S100B
24anaplastic ependymoma10.2MUC1, S100B
25granular cell leiomyosarcoma10.1
26clear cell ependymoma10.1VIM, MUC1
27desmoplastic small round cell tumor10.1MUC1, DES
28uterine fibroid10.1FH, DES
29tubular adenocarcinoma10.1ACTC1, MUC1
30hemangioblastoma10.1MUC1, S100B
31epithelioid sarcoma10.1VIM, MUC1
32mucoepidermoid carcinoma10.1MUC1, ACTC1
33secretory meningioma10.1VIM, MUC1
34tuberous sclerosis10.1S100B, VIM
35clear cell sarcoma10.1S100B, KIT
36cutaneous fibrous histiocytoma10.1S100B, ACTC1, DES
37myxoid liposarcoma10.1
38retinoblastoma10.1
39leiomyomatosis and renal cell cancer10.1
40syringocystadenoma papilliferum10.1
41smallpox10.1
42dedifferentiated liposarcoma10.1DES, KIT
43myoepithelioma10.1VIM, ACTC1, S100B
44malignant mixed mullerian tumor10.0VIM, KIT
45glomus tumor10.0DES, VIM, ACTC1
46benign breast phyllodes tumor10.0VIM, KIT
47uterine sarcoma10.0DES, KIT
48pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
49fibroma10.0ACTC1, VIM, DES
50medulloblastoma10.0S100B, ACTC1, DES

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to cutaneous leiomyosarcoma

Symptoms for Cutaneous Leiomyosarcoma

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Drugs & Therapeutics for Cutaneous Leiomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Cutaneous Leiomyosarcoma

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

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Anatomical Context for Cutaneous Leiomyosarcoma

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MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

31
Skin, Lymph node, Smooth muscle

Animal Models for Cutaneous Leiomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2KIT, S100B, ACTC1, MUC1
2MP:00053697.9DES, VIM, ACTC1, KIT
3MP:00053767.1KIT, FH, ACTC1, MUC1, VIM, DES

Publications for Cutaneous Leiomyosarcoma

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Articles related to Cutaneous Leiomyosarcoma:

(show all 49)
idTitleAuthorsYear
1
Recurrent cutaneous leiomyosarcoma of the inner thigh. (25900934)
2015
2
Cutaneous leiomyosarcoma - Case report. (25408738)
2014
3
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. (23851868)
2013
4
Rapid growing superficial cutaneous leiomyosarcoma of the face. (23717020)
2013
5
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. (23293965)
2013
6
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. (23984230)
2013
7
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. (24077407)
2013
8
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
9
Cutaneous leiomyosarcoma arising in a smallpox scar. (22799750)
2012
10
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
11
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. (21571171)
2011
12
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. (22019008)
2011
13
Cutaneous leiomyosarcoma on the trunk. (22147043)
2011
14
Superficial cutaneous leiomyosarcoma of the face: report of three cases. (21352334)
2011
15
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. (20579459)
2010
16
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
17
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. (20102404)
2010
18
Childhood cutaneous leiomyosarcoma. (19689533)
2009
19
Cutaneous leiomyosarcoma developing on a pacemaker pocket. (19389092)
2009
20
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. (19010751)
2009
21
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. (18986479)
2008
22
Cutaneous leiomyosarcoma in a pigeon. (18296669)
2008
23
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. (18429649)
2008
24
Cutaneous leiomyosarcoma: a tumor of the head and neck. (17451590)
2007
25
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
26
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
27
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
28
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. (16972950)
2006
29
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? (16634920)
2006
30
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
31
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. (14765271)
2004
32
Cutaneous leiomyosarcoma. (11884817)
2002
33
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
34
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. (10583188)
1999
35
Recurrent cutaneous leiomyosarcoma. (9646238)
1998
36
Cutaneous leiomyosarcoma. (9298873)
1997
37
Cutaneous leiomyosarcoma in a child. (9263308)
1997
38
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
39
Recurrent cutaneous leiomyosarcoma. (1617597)
1992
40
Cutaneous leiomyosarcoma. (1377726)
1992
41
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
42
Cutaneous leiomyosarcoma. (3439771)
1987
43
Cutaneous leiomyosarcoma: case reports and review of the literature. (3579172)
1987
44
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. (3319853)
1986
45
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. (7296963)
1981
46
Primary cutaneous leiomyosarcoma of the scalp in a child with lymph node metastases. (7272567)
1981
47
Cutaneous leiomyosarcoma in a long-eared bat, Plecotus townsendii virginianus, Handley. (5889797)
1965
48
Cutaneous leiomyosarcoma. (13240050)
1955
49
Cutaneous leiomyosarcoma with lymphatic spread: a report of two cases. (13277862)
1955

Variations for Cutaneous Leiomyosarcoma

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Expression for genes affiliated with Cutaneous Leiomyosarcoma

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Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for genes affiliated with Cutaneous Leiomyosarcoma

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Pathways related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.4VIM, DES
29.2KIT, ACTC1
39.0ACTC1, VIM, DES
4
Show member pathways
9.0ACTC1, VIM, DES
5
Show member pathways
8.0DES, VIM, MUC1, KIT

Compounds for genes affiliated with Cutaneous Leiomyosarcoma

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Compounds related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.7VIM, ACTC1
2monochloroacetic acid449.5KIT, VIM
3procollagen449.4ACTC1, VIM, DES
4eosin449.3S100B, MUC1, VIM
5bromodeoxyuridine449.2VIM, S100B, DES
6progestin449.2MUC1, VIM, DES
7adriamycin449.1MUC1, VIM, DES
8dihydrotestosterone44 28 24 1112.1DES, VIM, MUC1
9pyruvate449.0S100B, FH, MUC1
10hyaluronic acid44 2410.0VIM, DES, MUC1
11toluidine449.0KIT, VIM, DES
12orcein449.0VIM, ACTC1, S100B, DES
13proline449.0S100B, FH, VIM, DES
14iron44 249.9DES, VIM, ACTC1, S100B
15cytarabine44 50 1110.8KIT, MUC1, VIM
16agarose448.8S100B, KIT, MUC1
17biotin44 24 1110.8ACTC1, VIM, MUC1, DES
18gold448.8MUC1, KIT, DES
19valine448.7S100B, KIT, VIM
20imatinib44 50 1110.7S100B, DES, ACTC1, KIT
21cyclic amp44 249.7S100B, MUC1, VIM, DES
22aspartate448.6FH, KIT, S100B, VIM
23dexamethasone44 50 28 1111.6S100B, ACTC1, MUC1, VIM
24methionine448.5VIM, KIT, DES, S100B
25methotrexate50 44 1110.5MUC1, KIT, VIM
26oxygen44 249.5DES, FH, S100B, ACTC1, MUC1
27steroid448.4DES, S100B, KIT, ACTC1
28s 100448.4MUC1, ACTC1, VIM, DES, S100B
29reticulin448.4ACTC1, VIM, DES, MUC1, S100B
30mucicarmine448.4S100B, ACTC1, MUC1, VIM, DES
31b 723448.4S100B, ACTC1, MUC1, VIM, DES
32thymidine44 249.4DES, S100B, MUC1, KIT
33actinomycin d448.4VIM, KIT, MUC1, DES
34lactate448.2FH, S100B, VIM, DES, KIT
35creatinine448.0DES, S100B, FH, ACTC1, MUC1, VIM
36nitric oxide44 24 1110.0DES, MUC1, KIT, S100B
37cysteine447.9DES, VIM, MUC1, S100B, KIT
38threonine447.8KIT, S100B, MUC1, DES
39serine447.8S100B, MUC1, DES, VIM, KIT
40glucose447.7FH, ACTC1, MUC1, S100B, KIT, DES
41tyrosine447.7KIT, S100B, FH, ACTC1, DES, MUC1
42hematoxylin447.6MUC1, VIM, S100B, KIT, DES, ACTC1
43formaldehyde44 248.6S100B, ACTC1, MUC1, VIM, DES, KIT
44glycogen44 248.6KIT, ACTC1, MUC1, VIM, DES, S100B
45paraffin447.6ACTC1, DES, VIM, MUC1, S100B, KIT
46progesterone44 28 60 24 1111.5KIT, S100B, ACTC1, MUC1, VIM, DES
47testosterone44 60 24 1110.5ACTC1, KIT, S100B, DES, VIM, MUC1
48vegf447.5KIT, DES, S100B, ACTC1, MUC1, VIM
49estrogen447.5KIT, DES, MUC1, ACTC1, S100B, VIM
50retinoic acid44 248.5S100B, KIT, ACTC1, MUC1, VIM, DES

GO Terms for genes affiliated with Cutaneous Leiomyosarcoma

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Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.5FH, ACTC1, MUC1, VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.0ACTC1, VIM, DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.4VIM, DES
2identical protein bindingGO:00428028.7S100B, VIM, DES

Sources for Cutaneous Leiomyosarcoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet