MCID: CTN012
MIFTS: 41

Cutaneous Leiomyosarcoma malady

Cancer diseases, Skin diseases categories
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Summaries for Cutaneous Leiomyosarcoma

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33MalaCards
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MalaCards: Cutaneous Leiomyosarcoma, also known as leiomyosarcoma of the skin, is related to leiomyosarcoma and epithelioid leiomyosarcoma. An important gene associated with Cutaneous Leiomyosarcoma is FH (fumarate hydratase), and among its related pathways are Aurora B signaling and Cardiac Progenitor Differentiation. The compounds 2-methoxyethanol and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and smooth muscle, and related mouse phenotypes are normal and muscle.

Aliases & Classifications for Cutaneous Leiomyosarcoma

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8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

cutaneous leiomyosarcoma 8 62
leiomyosarcoma of the skin 8


External Ids:

Disease Ontology8 DOID:5273
SNOMED-CT58 254771006
NCIt40 C4484

Related Diseases for Cutaneous Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.0KIT, S100B, FH, ACTC1, MUC1, VIM
2epithelioid leiomyosarcoma30.5DES, VIM, ACTC1
3liposarcoma30.1VIM, DES
4leiomyoma29.8DES, VIM, ACTC1, FH, S100B, KIT
5granular cell leiomyosarcoma10.1
6fasciitis10.1ACTC1
7leiomyomatosis10.1FH
8infantile myofibromatosis10.1DES
9adenomatoid tumor10.1VIM
10juvenile xanthogranuloma10.1S100B
11histiocytosis10.1S100B
12ganglioglioma10.1S100B
13hidradenoma10.1MUC1
14hemangioma10.1ACTC1
15cystadenocarcinoma10.1MUC1
16carney triad10.1KIT
17papilloma10.1ACTC1
18adenosarcoma10.1DES, ACTC1
19syringoma10.0S100B, MUC1
20fibrous meningioma10.0S100B, MUC1
21embryonal rhabdomyosarcoma10.0DES, ACTC1
22alveolar soft part sarcoma10.0DES, VIM
23choroid plexus papilloma10.0MUC1, S100B
24syringocystadenoma papilliferum10.0
25myxoid liposarcoma10.0
26retinoblastoma10.0
27smallpox10.0
28anaplastic ependymoma10.0MUC1, S100B
29clear cell ependymoma10.0VIM, MUC1
30desmoplastic small round cell tumor10.0MUC1, DES
31uterine fibroid10.0FH, DES
32tubular adenocarcinoma10.0ACTC1, MUC1
33hemangioblastoma10.0MUC1, S100B
34epithelioid sarcoma10.0VIM, MUC1
35mucoepidermoid carcinoma10.0MUC1, ACTC1
36secretory meningioma10.0VIM, MUC1
37tuberous sclerosis10.0S100B, VIM
38clear cell sarcoma10.0S100B, KIT
39cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES
40dedifferentiated liposarcoma10.0DES, KIT
41myoepithelioma10.0VIM, ACTC1, S100B
42malignant mixed mullerian tumor10.0VIM, KIT
43glomus tumor10.0DES, VIM, ACTC1
44phyllode tumor10.0VIM, KIT
45uterine sarcoma10.0DES, KIT
46pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
47fibroma10.0ACTC1, VIM, DES
48medulloblastoma10.0S100B, ACTC1, DES
49carcinoid syndrome10.0ACTC1, MUC1
50granular cell tumor10.0DES, VIM, S100B

Graphical network of the top 20 diseases related to Cutaneous Leiomyosarcoma:



Diseases related to cutaneous leiomyosarcoma

Symptoms for Cutaneous Leiomyosarcoma

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Drugs & Therapeutics for Cutaneous Leiomyosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cutaneous Leiomyosarcoma

Search NIH Clinical Center for Cutaneous Leiomyosarcoma

Genetic Tests for Cutaneous Leiomyosarcoma

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Anatomical Context for Cutaneous Leiomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Cutaneous Leiomyosarcoma:

33
Skin, Lymph node, Smooth muscle

Animal Models for Cutaneous Leiomyosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cutaneous Leiomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2KIT, S100B, ACTC1, MUC1
2MP:00053697.9DES, VIM, ACTC1, KIT
3MP:00053767.1KIT, FH, ACTC1, MUC1, VIM, DES

Publications for Cutaneous Leiomyosarcoma

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52PubMed
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Articles related to Cutaneous Leiomyosarcoma:

(show all 46)
idTitleAuthorsYear
1
Huge and rapidly growing superficial cutaneous leiomyosarcoma on the face: rare location and unusual presentation. (23851868)
2013
2
Atypical cutaneous leiomyosarcoma with skip-lesion behavior. (23293965)
2013
3
Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. (23984230)
2013
4
Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. (24077407)
2013
5
It's not just who you are, it's also where you are: the cutaneous leiomyosarcoma dilemma. (22324176)
2012
6
Cutaneous leiomyosarcoma arising in a smallpox scar. (22799750)
2012
7
Cutaneous leiomyosarcoma originating in a symplastic pilar leiomyoma: a rare occurrence and potential diagnostic pitfall. (19780873)
2011
8
Mohs micrographic surgery for the treatment of cutaneous leiomyosarcoma. (21571171)
2011
9
Primary desmoplastic cutaneous leiomyosarcoma associated with high MIB-1 labeling index: a teaching case giving rise to diagnostic difficulties on a small biopsy specimen. (22019008)
2011
10
Cutaneous leiomyosarcoma on the trunk. (22147043)
2011
11
Superficial cutaneous leiomyosarcoma of the face: report of three cases. (21352334)
2011
12
A case of desmoplastic leiomyosarcoma: a rare variant of cutaneous leiomyosarcoma. (20579459)
2010
13
Cutaneous leiomyosarcoma and intramuscular myxoid liposarcoma in a patient with hereditary retinoblastoma. (20534095)
2010
14
Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. (20102404)
2010
15
Childhood cutaneous leiomyosarcoma. (19689533)
2009
16
Cutaneous leiomyosarcoma developing on a pacemaker pocket. (19389092)
2009
17
Cutaneous leiomyosarcoma arising in a tattoo - 'a tumour with no humour'. (19010751)
2009
18
Absence of fumarate hydratase mutation in a family with cutaneous leiomyosarcoma and renal cancer. (18986479)
2008
19
Cutaneous leiomyosarcoma in a pigeon. (18296669)
2008
20
Superficial cutaneous leiomyosarcoma: a rare, misleading tumor. (18429649)
2008
21
Cutaneous leiomyosarcoma: a tumor of the head and neck. (17451590)
2007
22
Primary cutaneous leiomyosarcoma: a histological and immunohistochemical study of 4 cases. (18416331)
2007
23
Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. (17343592)
2007
24
Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms. (16972948)
2006
25
Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature. (16972950)
2006
26
A case of cutaneous leiomyosarcoma with overexpression of KIT: do CD117 (KIT)-positive primary gastrointestinal stromal tumours of the skin exist? (16634920)
2006
27
Cutaneous metastatic malignant mixed mullerian tumour mimicking cutaneous leiomyosarcoma: a case report. (15491456)
2004
28
Primary cutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 7 cases. (14765271)
2004
29
Cutaneous leiomyosarcoma. (11884817)
2002
30
Metastatic cutaneous leiomyosarcoma from primary neoplasm of the mesentery. (11703527)
2001
31
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan. (10583188)
1999
32
Recurrent cutaneous leiomyosarcoma. (9646238)
1998
33
Cutaneous leiomyosarcoma. (9298873)
1997
34
Cutaneous leiomyosarcoma in a child. (9263308)
1997
35
Sclerotic primary cutaneous leiomyosarcoma. (8599440)
1995
36
Recurrent cutaneous leiomyosarcoma. (1617597)
1992
37
Cutaneous leiomyosarcoma. (1377726)
1992
38
Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation. (3294254)
1988
39
Cutaneous leiomyosarcoma. (3439771)
1987
40
Cutaneous leiomyosarcoma: case reports and review of the literature. (3579172)
1987
41
Cutaneous leiomyosarcoma--report of a case, immunohistochemical study and a review of literature. (3319853)
1986
42
Cutaneous leiomyosarcoma with coexistent superficial angioleiomyoma. (7296963)
1981
43
Primary cutaneous leiomyosarcoma of the scalp in a child with lymph node metastases. (7272567)
1981
44
Cutaneous leiomyosarcoma in a long-eared bat, Plecotus townsendii virginianus, Handley. (5889797)
1965
45
Cutaneous leiomyosarcoma. (13240050)
1955
46
Cutaneous leiomyosarcoma with lymphatic spread: a report of two cases. (13277862)
1955

Variations for Cutaneous Leiomyosarcoma

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Expression for genes affiliated with Cutaneous Leiomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Leiomyosarcoma

Search GEO for disease gene expression data for Cutaneous Leiomyosarcoma.

Pathways for genes affiliated with Cutaneous Leiomyosarcoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome, 53QIAGEN
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Pathways related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.4VIM, DES
29.2KIT, ACTC1
39.0ACTC1, VIM, DES
4
Show member pathways
9.0ACTC1, VIM, DES
5
Show member pathways
8.0DES, VIM, MUC1, KIT

Compounds for genes affiliated with Cutaneous Leiomyosarcoma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol459.7VIM, ACTC1
2monochloroacetic acid459.5KIT, VIM
3procollagen459.4ACTC1, VIM, DES
4eosin459.3S100B, MUC1, VIM
5bromodeoxyuridine459.2VIM, S100B, DES
6progestin459.2MUC1, VIM, DES
7adriamycin459.1MUC1, VIM, DES
8dihydrotestosterone45 29 24 1112.1DES, VIM, MUC1
9pyruvate459.0S100B, FH, MUC1
10hyaluronic acid45 2410.0VIM, DES, MUC1
11toluidine459.0KIT, VIM, DES
12orcein459.0VIM, ACTC1, S100B, DES
13proline459.0S100B, FH, VIM, DES
14iron45 249.9DES, VIM, ACTC1, S100B
15cytarabine45 51 1110.8KIT, MUC1, VIM
16agarose458.8S100B, KIT, MUC1
17biotin45 24 1110.8ACTC1, VIM, MUC1, DES
18gold458.8MUC1, KIT, DES
19valine458.7S100B, KIT, VIM
20imatinib45 51 1110.7S100B, DES, ACTC1, KIT
21cyclic amp45 249.7S100B, MUC1, VIM, DES
22aspartate458.6FH, KIT, S100B, VIM
23dexamethasone45 51 29 1111.6S100B, ACTC1, MUC1, VIM
24methionine458.5VIM, KIT, DES, S100B
25methotrexate51 45 1110.5MUC1, KIT, VIM
26oxygen45 249.5DES, FH, S100B, ACTC1, MUC1
27steroid458.4DES, S100B, KIT, ACTC1
28s 100458.4MUC1, ACTC1, VIM, DES, S100B
29reticulin458.4ACTC1, VIM, DES, MUC1, S100B
30mucicarmine458.4S100B, ACTC1, MUC1, VIM, DES
31b 723458.4S100B, ACTC1, MUC1, VIM, DES
32thymidine45 249.4DES, S100B, MUC1, KIT
33actinomycin d458.4VIM, KIT, MUC1, DES
34lactate458.2FH, S100B, VIM, DES, KIT
35creatinine458.0DES, S100B, FH, ACTC1, MUC1, VIM
36nitric oxide45 24 1110.0DES, MUC1, KIT, S100B
37cysteine457.9DES, VIM, MUC1, S100B, KIT
38threonine457.8KIT, S100B, MUC1, DES
39serine457.8S100B, MUC1, DES, VIM, KIT
40glucose457.7FH, ACTC1, MUC1, S100B, KIT, DES
41tyrosine457.7KIT, S100B, FH, ACTC1, DES, MUC1
42hematoxylin457.6MUC1, VIM, S100B, KIT, DES, ACTC1
43formaldehyde45 248.6S100B, ACTC1, MUC1, VIM, DES, KIT
44glycogen45 248.6KIT, ACTC1, MUC1, VIM, DES, S100B
45paraffin457.6ACTC1, DES, VIM, MUC1, S100B, KIT
46progesterone45 29 61 24 1111.5KIT, S100B, ACTC1, MUC1, VIM, DES
47testosterone45 61 24 1110.5ACTC1, KIT, S100B, DES, VIM, MUC1
48vegf457.5KIT, DES, S100B, ACTC1, MUC1, VIM
49estrogen457.5KIT, DES, MUC1, ACTC1, S100B, VIM
50retinoic acid45 248.5S100B, KIT, ACTC1, MUC1, VIM, DES

GO Terms for genes affiliated with Cutaneous Leiomyosarcoma

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16Gene Ontology
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Cellular components related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.5FH, ACTC1, MUC1, VIM

Biological processes related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, VIM, DES

Molecular functions related to Cutaneous Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.4VIM, DES
2identical protein bindingGO:0428028.7S100B, VIM, DES

Products for genes affiliated with Cutaneous Leiomyosarcoma

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Sources for Cutaneous Leiomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet