MCID: CTN007
MIFTS: 58

Cutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Cutaneous Leishmaniasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are Pentose phosphate pathway (hexose monophosphate shunt) and Pentose Phosphate Pathway (Erythrocyte). The drug meglumine and the compounds cycloheximide and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

cutaneous leishmaniasis 8 10
asian desert cutaneous leishmaniasis 8 60
diffuse cutaneous leishmaniasis 8 60
ethiopian cutaneous leishmaniasis 60
leishmaniasis diffuse cutaneous 44
leishmaniasis, cutaneous 60
leishmaniasis cutaneous 44
leproid leishmaniasis 8


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Disease Ontology8 DOID:9111
MeSH34 D016773
SNOMED-CT56 240637006
NCIt39 C34768
ICD1025 B55.1

Related Diseases for Cutaneous Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis32.1MDH2, MPI, MT-CYB, PGD, IL13, IL4
2visceral leishmaniasis30.8IFNG, LTA, PGD, IL4, LMLN, SLC11A1
3leprosy30.4SLC11A1
4dermatitis30.4IFNG, FOXP3, IL13, IL4
5lepromatous leprosy30.0IFNG, LTA, IL4
6sarcoidosis30.0IFNG, LTA, IL13, FCER2, SLC11A1
7pulmonary tuberculosis30.0SLC11A1, IL4, IFNG
8lymphopenia30.0PNP, IL4, FOXP3, IFNG
9tuberculosis30.0SLC11A1, PNP, IFNG, TNFRSF8, MDH2, IL4
10arthritis30.0IFNG, FOXP3, LTA, IL13, IL4, FCER2
11diabetes mellitus30.0FOXP3, G6PD
12erysipeloid10.4
13mucocutaneous leishmaniasis10.4
14granulomatous dermatitis10.3
15paronychia10.2
16ankylosing spondylitis10.2
17acquired immunodeficiency syndrome10.2
18panniculitis10.2
19spondylitis10.2
20lobomycosis10.0
21mechanical lagophthalmos10.0
22chromoblastomycosis10.0
23cutaneous lupus erythematosus10.0
24pulmonary sarcoidosis10.0
25cellulitis10.0
26psoriatic arthritis10.0
27tuberculoid leprosy10.0
28follicular mucinosis10.0
29herpes zoster10.0
30african tick-bite fever10.0
31basal cell carcinoma10.0
32blepharitis10.0
33blepharoconjunctivitis10.0
34ectropion10.0
35elephantiasis10.0
36lagophthalmos10.0
37lupus erythematosus10.0
38pericarditis10.0
39squamous cell carcinoma10.0
40trypanosomiasis10.0
41yaws10.0
42hepatitis10.0LTA
43nephrotic syndrome10.0IL13
44sjogren's syndrome10.0GZMA
45kawasaki disease10.0FCER2
46vitiligo10.0G6PD
47typhoid fever10.0SLC11A1
48brucellosis10.0SLC11A1
49myopathy10.0MT-CYB
50pneumonia10.0MT-CYB, IL13

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Clinical Features for Cutaneous Leishmaniasis

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Drugs & Therapeutics for Cutaneous Leishmaniasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Search CenterWatch for Cutaneous Leishmaniasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cutaneous Leishmaniasis

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Anatomical Context for Cutaneous Leishmaniasis

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32MalaCards
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MalaCards organs/tissues related to Cutaneous Leishmaniasis:

32
Skin, T cells, Testes, Monocytes, Lymph node, Whole blood, Kidney, Liver, Endothelial, Colon, Pancreas, Salivary gland

Animal Models for Cutaneous Leishmaniasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.0GZMA, TNFRSF8, FOXP3, LTA, IL13, IL4
2MP:00053979.9SLC11A1, IFNG, GZMA, TNFRSF8, FOXP3, G6PD
3MP:00107689.7G6PD, FOXP3, FH, GZMA, IFNG, MPI

Publications for Cutaneous Leishmaniasis

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50PubMed
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Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
2
LeishmaniaA braziliensis-Reactive T Cells Are Down-Regulated in Long-Term Cured Cutaneous Leishmaniasis, but the Renewal Capacity of T Effector Memory Compartments Is Preserved. (24303052)
2013
3
Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis. (23390069)
2013
4
CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFNI^(+)-mediated parasite killing in human cutaneous leishmaniasis. (23321919)
2013
5
Efficacy of glucantime for treatment of cutaneous leishmaniasis in Central Iran. (23537825)
2013
6
Blood feeding patterns of Nyssomyia intermedia and Nyssomyia neivai (Diptera, Psychodidae) in a cutaneous leishmaniasis endemic area of the Ribeira Valley, State of SALo Paulo, Brazil. (24270245)
2013
7
Assessment of drug resistance related genes as candidate markers for treatment outcome prediction of cutaneous leishmaniasis in Brazil. (23416123)
2013
8
Divergent profile of emerging cutaneous leishmaniasis in subtropical Brazil: new endemic areas in the southern frontier. (23457521)
2013
9
Leishmania major, the predominant Leishmania species responsible for cutaneous leishmaniasis in Mali. (23324218)
2013
10
Topical paromomycin with or without gentamicin for cutaneous leishmaniasis. (23388004)
2013
11
Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: a case series. (23816511)
2013
12
Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell. (23933281)
2013
13
Cluster randomised trial to evaluate the effectiveness of a vaccine against cutaneous leishmaniasis in the Caratinga microregion, south-east Brazil. (23423433)
2013
14
Dermoscopic features of cutaneous leishmaniasis. (23968138)
2013
15
Successful treatment of canine cutaneous leishmaniasis using radio-frequency induced heat (RFH) therapy. (22855755)
2012
16
Cruel disease, cruel medicine: self-treatment of cutaneous leishmaniasis with harmful chemical substances in Suriname. (22704264)
2012
17
Imported cutaneous leishmaniasis in a short-term traveler returning from Central Mali - The role of PCR. (22405679)
2012
18
Comparative analysis of the geographic distribution of the histopathological spectrum and Leishmania species of American cutaneous leishmaniasis in Brazil. (22714750)
2012
19
Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana. (22634889)
2012
20
Regulatory T-cell profile in early and late lesions of cutaneous leishmaniasis due to Leishmania major. (23626625)
2012
21
Molecular detection of Leishmania isolated from cutaneous leishmaniasis patients in Jask County, Hormozgan Province, Southern Iran, 2008. (22647811)
2012
22
Spatial analysis of eco-environmental risk factors of cutaneous leishmaniasis in Southern Iran. (22557853)
2012
23
Comparative study on the effectiveness of coumavecAr and zinc phosphide in controlling zoonotic cutaneous leishmaniasis in a hyperendemic focus in central iran. (23293775)
2012
24
Jessner lymphocytic infiltrate presenting on a cutaneous leishmaniasis scar: case report. (22764444)
2012
25
Consecutive cutaneous and visceral leishmaniasis manifestations involving a novel Leishmania species in two HIV patients in Thailand. (22764295)
2012
26
Topical treatment modalities for old world cutaneous leishmaniasis: a review. (22691282)
2012
27
Lupoid cutaneous leishmaniasis: a case report. (22984663)
2011
28
Radiofrequency-induced heat therapy as first-line treatment for cutaneous leishmaniasis. (21692665)
2011
29
First detection of Leishmania killicki (Kinetoplastida, Trypanosomatidae) in Ctenodactylus gundi (Rodentia, Ctenodactylidae), a possible reservoir of human cutaneous leishmaniasis in Tunisia. (21834996)
2011
30
Direct diagnosis of Leishmania species on serosity materials punctured from cutaneous leishmaniasis patients using PCR-RFLP. (21254238)
2011
31
Efficacy of Topical Liposomal Amphotericin B versus Intralesional Meglumine Antimoniate (Glucantime) in the Treatment of Cutaneous Leishmaniasis. (22174993)
2011
32
Can yeast-like form of Sporothrix schenckii confuse the direct parasitological diagnosis of American cutaneous leishmaniasis? (21340427)
2011
33
Auricular enlargement: an atypical presentation of old world cutaneous leishmaniasis. (21965856)
2011
34
Variation in clinical presentation and genotype of causative Leishmania major strain in cutaneous leishmaniasis in north and south Afghanistan. (21734125)
2011
35
Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis. (21734128)
2011
36
Comment on: Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19836815)
2010
37
Clinical efficacy and pharmacokinetics of antimony in cutaneous leishmaniasis patients treated with sodium stibogluconate. (20663995)
2010
38
Efficacy of photodynamic therapy in cutaneous leishmaniasis: a "hidden" local heat effect? (20673703)
2010
39
Urban transmission of American cutaneous leishmaniasis in Argentina: spatial analysis study. (20207869)
2010
40
Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial. (21200420)
2010
41
First report on isolation of Leishmania tropica from sandflies of a classical urban Cutaneous leishmaniasis focus in southern Iran. (20570590)
2010
42
Interleukin 17 production among patients with American cutaneous leishmaniasis. (19476435)
2009
43
Immune response to Leishmania antigen in anthroponotic cutaneous leishmaniasis. (19560211)
2009
44
Spontaneous cure of American cutaneous leishmaniasis due to Leishmania naiffi in two Dutch infantry soldiers. (20055858)
2009
45
CD8+ cytotoxic lymphocytes in cutaneous leishmaniasis]. (17063826)
2006
46
Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis. (11555399)
2001
47
Treatment of two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana modifies the immunohistological profile but not the disease outcome. (10632987)
1999
48
Polymerase chain reaction reveals Trypanosoma cruzi infection suspected by serology in cutaneous and mucocutaneous leishmaniasis patients. (10232785)
1999
49
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
50
Rodents as reservoir hosts of cutaneous leishmaniasis in Jordan. (7893175)
1994

Genetic Variations for Cutaneous Leishmaniasis

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Expression for genes affiliated with Cutaneous Leishmaniasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

Search GEO for disease gene expression data for Cutaneous Leishmaniasis.

Pathways for genes affiliated with Cutaneous Leishmaniasis

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems, 51QIAGEN, 29KEGG, 12EMD Millipore
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Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4PGD, G6PD
2
Hide members
10.4PGD, G6PD
310.4IL4, IL13
4
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10.4IL13, TNFRSF8
510.4IL4, IL13, IFNG
6
Hide members
10.4IL4, FOXP3, IFNG
7
Hide members
10.4IL4, LTA, FOXP3
810.3LTA, IL4, FCER2
9
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10.3FOXP3, GZMA, IFNG
10
Hide members
10.3IFNG, GZMA, IL4
11
Hide members
10.3IL4, IL13, LTA, IFNG
1210.3IL4, IL13, LTA, IFNG
13
Hide members
10.3IFNG, LTA, IL13, IL4
1410.3IFNG, LTA, IL13, IL4
15
Hide members
10.3IFNG, FOXP3, IL13, IL4
16
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10.3IFNG, IL13, IL4, FCER2
1710.3FH, G6PD, MDH2, PGD

Compounds for genes affiliated with Cutaneous Leishmaniasis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7LMLN, LTA, MT-CYB
2alpha-galactosylceramide4410.7IL4, IL13, IFNG
3amphotericin b4410.7IL13
4fumarate44 1111.7MT-CYB, MPI, G6PD, FH, IFNG
5okt34410.7IFNG, LTA, IL4, FCER2
6nadp+4410.7PGD, MT-CYB, MDH2, G6PD
7cellulose acetate4410.7G6PD, MDH2, MPI, PGD
8pentoxifylline44 1111.7LTA, IL13, IL4
9il 104410.7IFNG, LTA, IL13, IL4
106-phosphogluconate4410.7FH, G6PD, MDH2, MPI, PGD
11isocitrate4410.7FH, G6PD, MDH2, MPI, PGD
12hypoxanthine44 11 2412.7G6PD, PGD, IL4, PNP
13glatiramer acetate44 1111.7IL4, IL13, IFNG
14glucose 6-phosphate44 2411.7FH, G6PD, MDH2, MPI, PGD
15nad+4410.7FH, G6PD, MDH2, MT-CYB, PGD
16ribavirin44 49 1112.7PNP, IL4, G6PD, IFNG
17hydrocortisone44 2 59 1113.7FCER2
18mannose4410.7MPI, LTA, IL13, FCER2, SLC11A1
19neopterin4410.7IFNG, LTA, IL4, FCER2
206-phosphogluconolactone4410.7PGD, G6PD
21glucose4410.7PNP, PGD, MPI, MDH2
22nucleoside4410.7FH, MDH2, MPI, PGD, PNP
23malate4410.7FH, G6PD, MDH2, MPI, PGD, PNP
24glyceraldehyde 3-phosphate4410.7G6PD, MDH2, MPI, MT-CYB, PGD, PNP
25ionomycin4410.7IFNG, GZMA, LTA, IL13, IL4, FCER2
26allergens4410.7IFNG, IL13, IL4, FCER2
27il-124410.7IFNG, IL13, IL4
28succinate4410.6MT-CYB, MDH2, G6PD, FH
29prpp4410.6G6PD, PGD, PNP
30calcitriol44 59 11 2413.6IFNG, LTA, IL13, IL4, FCER2
31rantes4410.6IFNG, GZMA, LTA, IL4
32cyclosporin a44 28 5912.6IFNG, GZMA, TNFRSF8, FOXP3, LTA, IL13
33serine4410.6G6PD, MT-CYB, LTA, IL13, FCER2
34thymidine44 2411.6IFNG, TNFRSF8, MT-CYB, IL13, IL4, FCER2
35nitric oxide44 11 2412.6IFNG, FOXP3, MT-CYB, LTA, PGD, IL13
36superoxide44 2411.6GZMA, FH, G6PD, MDH2, MPI, MT-CYB
37starch4410.6MPI, MDH2, G6PD
38lactate4410.6FH, G6PD, MDH2, LTA, PGD, IL13
39h2o24410.6G6PD, MDH2, MT-CYB, LTA, PGD, IL13
40aspartate4410.5FH, G6PD, MDH2, MPI, MT-CYB, PGD
41oxazolone4410.5IL4, IL13
42nadh44 11 2412.5FH, G6PD, MDH2, MT-CYB, PGD
436-aminonicotinamide4410.5PGD, G6PD
44oxygen44 2411.5GZMA, FH, MT-CYB, SLC11A1
45gm-csf44 2811.4IFNG
46phenazine methosulfate4410.4MDH2, G6PD
47budesonide44 49 1112.4IL4, IL13, IFNG
48atp44 2811.3FH, G6PD, MDH2, MT-CYB, PGD, FCER2
49citrate4410.2PGD, MDH2, G6PD, FH
50cysteine449.9IFNG, GZMA, IL13, IL4, LMLN, FCER2

GO Terms for genes affiliated with Cutaneous Leishmaniasis

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16Gene Ontology
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Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCER2, IL4, IL13, IFNG

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1pentose biosynthetic processGO:01932210.7PGD, G6PD
2positive regulation of killing of cells of other organismGO:05171210.7IFNG, FCER2
3pentose-phosphate shunt, oxidative branchGO:00905110.7G6PD, PGD
4defense response to protozoanGO:04283210.7SLC11A1, IL4, IFNG
5negative regulation of chronic inflammatory responseGO:00267710.6FOXP3, IL4
6regulation of proton transportGO:01015510.6IL4, IL13
7positive regulation of isotype switching to IgG isotypesGO:04830410.6IFNG, IL4
8positive regulation of T cell proliferationGO:04210210.6IFNG, IL4, PNP
9positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.6LTA, FCER2
10positive regulation of immunoglobulin productionGO:00263910.5IL13, FOXP3
11positive regulation of MHC class II biosynthetic processGO:04534810.5IL4, IFNG
12positive regulation of chemokine biosynthetic processGO:04508010.5IL4, IFNG
13negative regulation of growth of symbiont in hostGO:04413010.4LTA, IFNG
14response to ethanolGO:04547110.4G6PD, IL13, IL4
15pentose-phosphate shuntGO:00609810.3PGD, G6PD
16response to drugGO:04249310.0PNP, IL4, LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.3IL4, IL13, LTA, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Cutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet