MCID: CTN007
MIFTS: 55

Cutaneous Leishmaniasis malady

Infectious diseases category
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Summaries for Cutaneous Leishmaniasis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to leishmaniasis and leprosy. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are IL4-mediated signaling events and Glucocorticoid receptor regulatory network. The drug meglumine and the compounds fe2+ and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are digestive/alimentary and immune system.

Wikipedia:65 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 62UMLS, 45Novoseek, 35MeSH, 40NCIt, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

cutaneous leishmaniasis 8 10
asian desert cutaneous leishmaniasis 8 62
diffuse cutaneous leishmaniasis 8 62
ethiopian cutaneous leishmaniasis 62
leishmaniasis diffuse cutaneous 45
leishmaniasis, cutaneous 62
leishmaniasis cutaneous 45
leproid leishmaniasis 8


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Disease Ontology8 DOID:9111
MeSH35 D016773
SNOMED-CT58 240637006
NCIt40 C34768
ICD1025 B55.1

Related Diseases for Cutaneous Leishmaniasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis31.9PGD, IL13, SLC11A1, MT-CYB, MPI, IFNG
2leprosy30.6SLC11A1
3visceral leishmaniasis30.6LTA, SLC11A1, PGD, IFNG
4dermatitis30.4IFNG, IL13
5pulmonary tuberculosis30.1IFNG, SLC11A1
6lepromatous leprosy30.1LTA, IFNG
7pulmonary sarcoidosis30.1IFNG, LTA
8sarcoidosis29.9LTA, SLC11A1, IFNG, FCER2, IL13
9arthritis29.9IL13, FCER2, IFNG, LTA, SLC11A1
10erysipeloid10.4
11mucocutaneous leishmaniasis10.4
12blindness10.4
13granulomatous dermatitis10.3
14ankylosing spondylitis10.2
15acquired immunodeficiency syndrome10.2
16paronychia10.2
17panniculitis10.2
18spondylitis10.2
19iron metabolism disease10.1MT-CYB, SLC11A1
20chromoblastomycosis10.1
21tuberculoid leprosy10.1
22follicular mucinosis10.1
23herpes zoster10.1
24african tick-bite fever10.1
25psoriatic arthritis10.1
26lobomycosis10.1
27basal cell carcinoma10.1
28blepharitis10.1
29blepharoconjunctivitis10.1
30cellulitis10.1
31diabetes mellitus10.1
32ectropion10.1
33elephantiasis10.1
34lagophthalmos10.1
35lupus erythematosus10.1
36lymphopenia10.1
37pericarditis10.1
38trypanosomiasis10.1
39tuberculosis10.1
40yaws10.1
41mycobacterium marinum10.1
42endotheliitis10.1
43allergic rhinitis10.0FCER2, IL13
44lipoid nephrosis10.0FCER2, IL13
45pneumonia10.0IL13, MT-CYB
46aspergillosis10.0MT-CYB, IFNG
47bronchiolitis10.0FCER2, IL13
48chronic granulomatous disease10.0IFNG, MT-CYB
49juvenile rheumatoid arthritis10.0SLC11A1, LTA
50bullous pemphigoid10.0IL13, FCER2

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Symptoms for Cutaneous Leishmaniasis

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Drugs & Therapeutics for Cutaneous Leishmaniasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cutaneous Leishmaniasis

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Anatomical Context for Cutaneous Leishmaniasis

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33MalaCards
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MalaCards organs/tissues related to Cutaneous Leishmaniasis:

33
Skin, T cells, Monocytes, Testes, Whole blood, Salivary gland, Pancreas, Liver, Kidney, Colon, Lymph node, Endothelial

Animal Models for Cutaneous Leishmaniasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4FCER2, IFNG, IL13, SLC11A1
2MP:00053878.1LTA, SLC11A1, IL13, IFNG, FCER2
3MP:00053977.7LTA, SLC11A1, IL13, IFNG, FCER2, MPI
4MP:00107687.6MPI, FCER2, IFNG, IL13, SLC11A1, LTA

Publications for Cutaneous Leishmaniasis

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Sources:
52PubMed
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Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 591)
idTitleAuthorsYear
1
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
2
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
3
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
4
LeishmaniaA braziliensis-Reactive T Cells Are Down-Regulated in Long-Term Cured Cutaneous Leishmaniasis, but the Renewal Capacity of T Effector Memory Compartments Is Preserved. (24303052)
2013
5
Leishmanicidal activity of amphotericin B encapsulated in PLGA-DMSA nanoparticles to treat cutaneous leishmaniasis in C57BL/6 mice. (23891944)
2013
6
Cluster of zoonotic cutaneous leishmaniasis (Leishmania major) in European travelers returning from Turkmenistan. (24165385)
2013
7
Cutaneous leishmaniasis with unusual clinical and histological presentation: report of four cases. (23690110)
2013
8
Molecular characterization of leishmania infection from naturally infected sand flies caught in a focus of cutaneous leishmaniasis (eastern iran). (24409437)
2013
9
Simultaneous infection with Leishmania (Viannia) braziliensis and L. (V.) lainsoni in a Peruvian patient with cutaneous leishmaniasis. (23382155)
2013
10
Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis. (23390069)
2013
11
Travelers with cutaneous leishmaniasis cured without systemic therapy. (23633111)
2013
12
Sandflies (Diptera: Psychodidae) in rural and urban environments in an endemic area of cutaneous leishmaniasis in southern Brazil. (23778669)
2013
13
Cutaneous leishmaniasis in Al Hassa, Saudi Arabia: epidemiological trends from 2000 to 2010. (23790342)
2013
14
Outbreak of cutaneous leishmaniasis in Fuenlabrada, Madrid. (23567452)
2013
15
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
16
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
17
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
18
Cutaneous leishmaniasis acquired in Jura, France. (22257720)
2012
19
Correlation of clinical, parasitological and histopathological diagnosis of cutaneous leishmaniasis in an endemic region in Sri Lanka. (23292056)
2012
20
First case of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Suriname. (22556081)
2012
21
Latency time in cutaneous leishmaniasis. (21505401)
2011
22
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
23
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
24
Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis. (21747837)
2011
25
Lupoid cutaneous leishmaniasis: a case report. (22984663)
2011
26
An outbreak of suspected cutaneous leishmaniasis in Ghana: lessons learnt and preparation for future outbreaks. (21765823)
2011
27
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
28
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
29
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
30
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
31
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
32
Cutaneous leishmaniasis of the lid: a report of nine cases. (20157413)
2010
33
Eight cases of feline cutaneous leishmaniasis in Texas. (20826847)
2010
34
Evaluation of intralesional 0.2% ciprofloxacin as a treatment for cutaneous leishmaniasis. (20214164)
2010
35
The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. (20493664)
2010
36
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. (20854864)
2010
37
Molecular characterization of Leishmania species isolated from cutaneous leishmaniasis in Yemen. (20862227)
2010
38
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
39
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
40
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
41
Interleukin 17 production among patients with American cutaneous leishmaniasis. (19476435)
2009
42
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. (18347075)
2008
43
Evaluation of meglumine antimoniate effects on liver, kidney and pancreas function tests in patients with cutaneous leishmaniasis. (17951131)
2007
44
Ocular involvement in cutaneous leishmaniasis four cases with blepharoconjunctivitis. (15117121)
2004
45
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
46
The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis. (9951957)
1999
47
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
48
Anergic cutaneous leishmaniasis versus lobomycosis. (8737881)
1996
49
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
50
Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. (8132347)
1994

Variations for Cutaneous Leishmaniasis

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Expression for genes affiliated with Cutaneous Leishmaniasis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

Search GEO for disease gene expression data for Cutaneous Leishmaniasis.

Pathways for genes affiliated with Cutaneous Leishmaniasis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 54R&D Systems, 30KEGG
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Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LTA, FCER2
29.4IL13, IFNG
39.4IL13, IFNG
49.4IFNG, IL13
5
Show member pathways
9.3LTA, IFNG
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3LTA, IFNG
7
Show member pathways
IL27-mediated signaling events38
9.3IFNG, LTA
88.8LTA, IL13, IFNG
9
Show member pathways
8.8LTA, IL13, IFNG
108.8LTA, IL13, IFNG
11
Show member pathways
8.8LTA, IL13, IFNG
12
Show member pathways
8.4FCER2, IFNG, IL13, LTA

Compounds for genes affiliated with Cutaneous Leishmaniasis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1fe2+459.9MT-CYB, SLC11A1
2alpha-galactosylceramide459.8IL13, IFNG
3glatiramer acetate45 1110.8IL13, IFNG
4pirfenidone45 6110.8IL13, IFNG
5amphotericin b459.8IL13, IFNG
6il-12459.8IFNG, IL13
7indoleamine459.8IFNG, IL13
8nickel45 2410.7IL13, SLC11A1
96-phosphogluconate459.7MPI, PGD
10fumarate45 1110.6IFNG, MT-CYB, MPI
11gm-csf45 2910.6IFNG, IL13
12budesonide45 51 1111.6IFNG, IL13
13cellulose acetate459.6MPI, PGD
14isocitrate459.5MPI, PGD
15nadp+459.5MT-CYB, PGD
16allergens459.4IL13, IFNG, FCER2
17hydrocortisone45 3 61 1112.4FCER2, IFNG, IL13
18okt3459.4LTA, IFNG, FCER2
19neopterin459.3FCER2, IFNG, LTA
20fluticasone propionate45 51 61 1112.3IL13, IFNG
21herbimycin a45 6110.3LTA, IFNG, FCER2
22sb 20358045 6110.3FCER2, IFNG, IL13
23glyceraldehyde 3-phosphate459.2MPI, PGD, MT-CYB
24salbutamol45 51 29 24 1113.2IL13, FCER2
25il 10459.2IFNG, IL13, LTA
26pentoxifylline45 1110.2LTA, IL13, IFNG
27prednisolone45 29 1111.2LTA, IL13, IFNG
28endotoxin459.2LTA, IL13, IFNG
29rantes459.1LTA, IL13, IFNG
30indomethacin45 29 61 1112.1LTA, IL13, IFNG
31histamine45 29 2411.0FCER2, IFNG, IL13
32thymidine45 2410.0FCER2, MT-CYB, IFNG, IL13
33fmlp458.9LTA, IL13, MT-CYB, FCER2
34superoxide45 249.9MPI, FCER2, PGD, MT-CYB
35ionomycin458.8FCER2, IFNG, IL13, LTA
36calcitriol45 61 24 1111.8FCER2, IFNG, IL13, LTA
37pge2458.8FCER2, IFNG, IL13, LTA
38threonine458.8LTA, IL13, MT-CYB, FCER2
39dexamethasone45 51 29 1111.8LTA, IL13, IFNG, FCER2
40mannose458.7MPI, FCER2, IL13, SLC11A1, LTA
41lactate458.5LTA, IL13, PGD, FCER2
42retinoic acid45 249.5LTA, IL13, IFNG, FCER2
43aspartate458.5MPI, PGD, MT-CYB, IL13, SLC11A1
44oxygen45 249.5LTA, SLC11A1, MT-CYB, PGD
45serine458.4FCER2, FCN2, MT-CYB, IL13, LTA
46h2o2458.4PGD, MT-CYB, IL13, LTA
47cycloheximide458.4FCER2, MT-CYB, IFNG, IL13, LTA
48glutamate458.4PGD, MT-CYB, IL13, LTA
49glucose458.3LTA, MT-CYB, PGD, MPI
50nitric oxide45 24 119.2LTA, SLC11A1, IL13, IFNG, MT-CYB, PGD

GO Terms for genes affiliated with Cutaneous Leishmaniasis

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16Gene Ontology
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Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IFNG, FCER2

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of killing of cells of other organismGO:0517129.7IFNG, FCER2
2defense response to protozoanGO:0428329.7IFNG, SLC11A1
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, FCER2
4protein import into nucleus, translocationGO:0000609.6SLC11A1, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.4LTA, IFNG
6cellular component movementGO:0069289.4IL13, IFNG
7positive regulation of interferon-gamma productionGO:0327299.4LTA, SLC11A1
8response to lipopolysaccharideGO:0324969.1IL13, SLC11A1, LTA
9humoral immune responseGO:0069599.0LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8LTA, IL13, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Leishmaniasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet