MCID: CTN007
MIFTS: 58

Cutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Cutaneous Leishmaniasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to leishmaniasis and visceral leishmaniasis. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are Pentose phosphate pathway (hexose monophosphate shunt) and Pentose Phosphate Pathway (Erythrocyte). The drug meglumine and the compounds cycloheximide and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 34MeSH, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

cutaneous leishmaniasis 8 10
asian desert cutaneous leishmaniasis 8 60
diffuse cutaneous leishmaniasis 8 60
ethiopian cutaneous leishmaniasis 60
leishmaniasis diffuse cutaneous 44
leishmaniasis, cutaneous 60
leishmaniasis cutaneous 44
leproid leishmaniasis 8


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Disease Ontology8 DOID:9111
MeSH34 D016773
SNOMED-CT56 240637006
NCIt39 C34768
ICD1025 B55.1

Related Diseases for Cutaneous Leishmaniasis

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17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis32.1MDH2, MPI, MT-CYB, PGD, IL13, IL4
2visceral leishmaniasis30.8IFNG, LTA, PGD, IL4, LMLN, SLC11A1
3leprosy30.4SLC11A1
4dermatitis30.4IFNG, FOXP3, IL13, IL4
5lepromatous leprosy30.0IFNG, LTA, IL4
6sarcoidosis30.0IFNG, LTA, IL13, FCER2, SLC11A1
7pulmonary tuberculosis30.0SLC11A1, IL4, IFNG
8lymphopenia30.0PNP, IL4, FOXP3, IFNG
9tuberculosis30.0SLC11A1, PNP, IFNG, TNFRSF8, MDH2, IL4
10arthritis30.0IFNG, FOXP3, LTA, IL13, IL4, FCER2
11diabetes mellitus30.0FOXP3, G6PD
12erysipeloid10.4
13mucocutaneous leishmaniasis10.4
14granulomatous dermatitis10.3
15paronychia10.2
16ankylosing spondylitis10.2
17acquired immunodeficiency syndrome10.2
18panniculitis10.2
19spondylitis10.2
20lobomycosis10.0
21mechanical lagophthalmos10.0
22chromoblastomycosis10.0
23cutaneous lupus erythematosus10.0
24pulmonary sarcoidosis10.0
25cellulitis10.0
26psoriatic arthritis10.0
27tuberculoid leprosy10.0
28follicular mucinosis10.0
29herpes zoster10.0
30african tick-bite fever10.0
31basal cell carcinoma10.0
32blepharitis10.0
33blepharoconjunctivitis10.0
34ectropion10.0
35elephantiasis10.0
36lagophthalmos10.0
37lupus erythematosus10.0
38pericarditis10.0
39squamous cell carcinoma10.0
40trypanosomiasis10.0
41yaws10.0
42hepatitis10.0LTA
43nephrotic syndrome10.0IL13
44sjogren's syndrome10.0GZMA
45kawasaki disease10.0FCER2
46vitiligo10.0G6PD
47typhoid fever10.0SLC11A1
48brucellosis10.0SLC11A1
49myopathy10.0MT-CYB
50pneumonia10.0MT-CYB, IL13

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Clinical Features for Cutaneous Leishmaniasis

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Drugs & Therapeutics for Cutaneous Leishmaniasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Search CenterWatch for Cutaneous Leishmaniasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cutaneous Leishmaniasis

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Anatomical Context for Cutaneous Leishmaniasis

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32MalaCards
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MalaCards organs/tissues related to Cutaneous Leishmaniasis:

32
Skin, T cells, Testes, Monocytes, Lymph node, Whole blood, Kidney, Liver, Endothelial, Colon, Pancreas, Salivary gland

Animal Models for Cutaneous Leishmaniasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.0GZMA, TNFRSF8, FOXP3, LTA, IL13, IL4
2MP:00053979.9SLC11A1, IFNG, GZMA, TNFRSF8, FOXP3, G6PD
3MP:00107689.7G6PD, FOXP3, FH, GZMA, IFNG, MPI

Publications for Cutaneous Leishmaniasis

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50PubMed
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Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Molecular characterization of leishmania infection from naturally infected sand flies caught in a focus of cutaneous leishmaniasis (eastern iran). (24409437)
2013
2
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update. (23637917)
2013
3
The sandfly fauna, anthropophily and the seasonal activities of Pintomyia spinicrassa (Diptera: Psychodidae: Phlebotominae) in a focus of cutaneous leishmaniasis in northeastern Colombia. (23778653)
2013
4
Long-term efficacy of single-dose radiofrequency-induced heat therapy vs. intralesional antimonials for cutaneous leishmaniasis in India. (23298394)
2013
5
Intermediate/borderline disseminated cutaneous leishmaniasis. (23231577)
2013
6
Cutaneous leishmaniasis: new dermoscopic findings. (23789601)
2013
7
First molecular identification of Leishmania species in a new endemic area of cutaneous leishmaniasis in Lorestan, Iran. (23827149)
2013
8
An epidemiological study of cutaneous leishmaniasis in Al-jabal Al-gharbi, Libya. (23467624)
2013
9
An atypical case of cutaneous leishmaniasis caused by Leishmania infantum in Portugal. (24314782)
2013
10
Phlebotominae of epidemiological importance in cutaneous leishmaniasis in northwestern Argentina: risk maps and ecological niche models. (22827261)
2013
11
Misdiagnosis of cutaneous leishmaniasis and recurrence after surgical excision. (24109111)
2013
12
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
13
Correlation of clinical, parasitological and histopathological diagnosis of cutaneous leishmaniasis in an endemic region in Sri Lanka. (23292056)
2012
14
Cutaneous leishmaniasis in northeastern Brazil: a critical appraisal of studies conducted in State of Pernambuco. (22836662)
2012
15
Occupationally acquired american cutaneous leishmaniasis. (23227369)
2012
16
First detection of Leishmania major DNA in Sergentomyia (Spelaeomyia) darlingi from cutaneous leishmaniasis foci in Mali. (22276095)
2012
17
Peridomiciliary breeding sites of phlebotomine sand flies (Diptera: Psychodidae) in an endemic area of American cutaneous leishmaniasis in southeastern Brazil. (23091196)
2012
18
Evaluation of anti-lived and anti-fixed Leishmania (Viannia) braziliensis promastigote IgG antibodies detected by flow cytometry for diagnosis and post-therapeutic cure assessment in localized cutaneous leishmaniasis. (23007034)
2012
19
Old World cutaneous leishmaniasis. (23286822)
2012
20
IL-23 and IL-27 Levels in Macrophages Collected from Peripheral Blood of Patients with Healing Vs Non-Healing Form of Cutaneous Leishmaniasis. (23133467)
2012
21
Natural infection of North African gundi (Ctenodactylus gundi) by Leishmania tropica in the focus of cutaneous leishmaniasis, Southeast Tunisia. (22665601)
2012
22
Increased detection of cutaneous leishmaniasis in Norway by use of polymerase chain reaction. (22716214)
2012
23
Cutaneous leishmaniasis with pseudoepitheliomatous hyperplasia simulating squamous cell carcinoma. (21778837)
2011
24
Re: AlKhodair R, Al-Khenaizan S. Fish tank granuloma: misdiagnosed as cutaneous leishmaniasis. Int J Dermatol 2010, 49: 53-55. (21182513)
2011
25
Treatment of imported New World cutaneous leishmaniasis in Germany. (22004484)
2011
26
A patient presenting with diffuse cutaneous leishmaniasis (DCL) as a first indicator of HIV infection in India. (21734126)
2011
27
Phlebotomus papatasi and Meriones libycus as the vector and reservoir host of cutaneous leishmaniasis in Qomrood District, Qom Province, central Iran. (21771429)
2011
28
Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. (21460009)
2011
29
Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica. (21129042)
2011
30
Spatial distribution of phlebotomine sand flies in the Aydin Mountains and surroundings: the main focus of cutaneous leishmaniasis in western Turkey. (21366787)
2011
31
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
32
Eight cases of feline cutaneous leishmaniasis in Texas. (20826847)
2010
33
Molecular characterization of Leishmania species isolated from cutaneous leishmaniasis in Yemen. (20862227)
2010
34
The changing profile of cutaneous leishmaniasis in a focus of the disease in Jahrom district, southern Iran. (20819305)
2010
35
Environmental risk factors for the incidence of American cutaneous leishmaniasis in a sub-Andean zone of Colombia (Chaparral, Tolima). (20134000)
2010
36
Dynamics of Leishmania infection rates in Rhombomys opimus (Rodentia: Gerbillinae) population of an endemic focus of zoonotic cutaneous leishmaniasis in Iran. (20390397)
2010
37
First cases of cutaneous leishmaniasis caused by Leishmania (Viannia) naiffi infection in Surinam. (20348504)
2010
38
Epidemiologic and clinical features of cutaneous leishmaniasis in southeastern Tunisia. (21036833)
2010
39
Systemic and compartmentalised immune responses in a Leishmania braziliensis-macaque model of self-healing cutaneous leishmaniasis. (20546932)
2010
40
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
41
Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. (19356780)
2009
42
Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production. (19480861)
2009
43
Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. (14687718)
2003
44
Erysipeloid cutaneous leishmaniasis: treatment with a new, topical, pure herbal extract. (12695130)
2003
45
American cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the T-helper 1 cell response. (12942392)
2003
46
Interleukin (IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12. (11237813)
2001
47
Risk factors for onset of cutaneous and mucocutaneous leishmaniasis in Bolivia. (9242324)
1997
48
Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis. (9367403)
1997
49
Fifteen years of cutaneous and mucocutaneous leishmaniasis in Bolivia: a retrospective study. (8465401)
1993
50
Evaluation of T-cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis. (2957642)
1987

Genetic Variations for Cutaneous Leishmaniasis

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Expression for genes affiliated with Cutaneous Leishmaniasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

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Pathways for genes affiliated with Cutaneous Leishmaniasis

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems, 51QIAGEN, 29KEGG, 12EMD Millipore
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Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4PGD, G6PD
2
Hide members
10.4PGD, G6PD
310.4IL4, IL13
4
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10.4IL13, TNFRSF8
510.4IL4, IL13, IFNG
6
Hide members
10.4IL4, FOXP3, IFNG
7
Hide members
10.4IL4, LTA, FOXP3
810.3LTA, IL4, FCER2
9
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10.3FOXP3, GZMA, IFNG
10
Hide members
10.3IFNG, GZMA, IL4
11
Hide members
10.3IL4, IL13, LTA, IFNG
1210.3IL4, IL13, LTA, IFNG
13
Hide members
10.3IFNG, LTA, IL13, IL4
1410.3IFNG, LTA, IL13, IL4
15
Hide members
10.3IFNG, FOXP3, IL13, IL4
16
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10.3IFNG, IL13, IL4, FCER2
1710.3FH, G6PD, MDH2, PGD

Compounds for genes affiliated with Cutaneous Leishmaniasis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7LMLN, LTA, MT-CYB
2alpha-galactosylceramide4410.7IL4, IL13, IFNG
3amphotericin b4410.7IL13
4fumarate44 1111.7FH, G6PD, IFNG, MT-CYB, MPI
5okt34410.7IFNG, FCER2, IL4, LTA
6nadp+4410.7G6PD, MDH2, PGD, MT-CYB
7cellulose acetate4410.7PGD, MPI, MDH2, G6PD
8pentoxifylline44 1111.7IL13, LTA, IL4
9il 104410.7IL13, LTA, IL4, IFNG
106-phosphogluconate4410.7MPI, PGD, FH, G6PD, MDH2
11isocitrate4410.7FH, G6PD, PGD, MDH2, MPI
12hypoxanthine44 11 2412.7G6PD, PGD, IL4, PNP
13glatiramer acetate44 1111.7IL13, IL4, IFNG
14glucose 6-phosphate44 2411.7FH, G6PD, MDH2, MPI, PGD
15nad+4410.7G6PD, FH, PGD, MT-CYB, MDH2
16ribavirin44 49 1112.7PNP, IFNG, G6PD, IL4
17hydrocortisone44 2 59 1113.7FCER2
18mannose4410.7IL13, SLC11A1, LTA, MPI, FCER2
19neopterin4410.7IFNG, FCER2, IL4, LTA
206-phosphogluconolactone4410.7G6PD, PGD
21glucose4410.7PNP, MPI, MDH2, PGD
22nucleoside4410.7FH, MPI, PNP, PGD, MDH2
23malate4410.7PNP, PGD, MPI, G6PD, FH, MDH2
24glyceraldehyde 3-phosphate4410.7MDH2, G6PD, MT-CYB, PNP, MPI, PGD
25ionomycin4410.7IFNG, LTA, IL13, FCER2, GZMA, IL4
26allergens4410.7FCER2, IL4, IL13, IFNG
27il-124410.7IL13, IFNG, IL4
28succinate4410.6G6PD, MDH2, MT-CYB, FH
29prpp4410.6G6PD, PGD, PNP
30calcitriol44 59 11 2413.6FCER2, IL4, IL13, LTA, IFNG
31rantes4410.6GZMA, IL4, LTA, IFNG
32cyclosporin a44 28 5912.6IL13, IFNG, LTA, FOXP3, TNFRSF8, GZMA
33serine4410.6G6PD, MT-CYB, LTA, IL13, FCER2
34thymidine44 2411.6MT-CYB, IFNG, IL13, FCER2, PNP, TNFRSF8
35nitric oxide44 11 2412.6FCER2, IL13, PGD, LTA, MT-CYB, FOXP3
36superoxide44 2411.6MDH2, FCER2, PGD, MPI, G6PD, FH
37starch4410.6MPI, G6PD, MDH2
38lactate4410.6IL13, FH, PGD, G6PD, MDH2, FCER2
39h2o24410.6LTA, PGD, IL13, G6PD, MT-CYB, MDH2
40aspartate4410.5MDH2, PNP, IL13, PGD, G6PD, FH
41phenazine methosulfate4410.5MDH2, G6PD
42nadh44 11 2412.5MT-CYB, MDH2, FH, G6PD, PGD
43oxazolone4410.5IL4, IL13
44oxygen44 2411.5MT-CYB, FH, SLC11A1, GZMA
456-aminonicotinamide4410.5G6PD, PGD
46gm-csf44 2811.4IFNG
47budesonide44 49 1112.4IL4, IL13, IFNG
48atp44 2811.3PNP, FCER2, PGD, FH, G6PD, MDH2
49citrate4410.2G6PD, MDH2, FH, PGD
50cysteine449.9IL4, IL13, PNP, GZMA, FCER2, IFNG

GO Terms for genes affiliated with Cutaneous Leishmaniasis

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16Gene Ontology
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Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCER2, IL4, IL13, IFNG

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1pentose biosynthetic processGO:01932210.7PGD, G6PD
2positive regulation of killing of cells of other organismGO:05171210.7IFNG, FCER2
3pentose-phosphate shunt, oxidative branchGO:00905110.7G6PD, PGD
4defense response to protozoanGO:04283210.7SLC11A1, IL4, IFNG
5negative regulation of chronic inflammatory responseGO:00267710.6FOXP3, IL4
6regulation of proton transportGO:01015510.6IL4, IL13
7positive regulation of isotype switching to IgG isotypesGO:04830410.6IFNG, IL4
8positive regulation of T cell proliferationGO:04210210.6IFNG, IL4, PNP
9positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.6LTA, FCER2
10positive regulation of immunoglobulin productionGO:00263910.5IL13, FOXP3
11positive regulation of MHC class II biosynthetic processGO:04534810.5IL4, IFNG
12positive regulation of chemokine biosynthetic processGO:04508010.5IL4, IFNG
13negative regulation of growth of symbiont in hostGO:04413010.4LTA, IFNG
14response to ethanolGO:04547110.4G6PD, IL13, IL4
15pentose-phosphate shuntGO:00609810.3PGD, G6PD
16response to drugGO:04249310.0PNP, IL4, LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.3IL4, IL13, LTA, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

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  • Antibodies
  • Proteins
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Sources for Cutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet