MCID: CTN007
MIFTS: 55

Cutaneous Leishmaniasis malady

Infectious diseases category

Summaries for Cutaneous Leishmaniasis

About this section


Disease Ontology:9 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards based summary: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to leishmaniasis and leprosy. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are IL4-mediated signaling events and Glucocorticoid receptor regulatory network. The drug meglumine and the compounds fe2+ and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are digestive/alimentary and immune system.

Wikipedia:64 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

About this section

Cutaneous Leishmaniasis, Aliases & Descriptions:

Name: Cutaneous Leishmaniasis 31 9 11
Asian Desert Cutaneous Leishmaniasis 9 61
Diffuse Cutaneous Leishmaniasis 9 61
Ethiopian Cutaneous Leishmaniasis 61
 
Leishmaniasis Diffuse Cutaneous 44
Leishmaniasis, Cutaneous 61
Leishmaniasis Cutaneous 44
Leproid Leishmaniasis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:9111
NCIt39 C34768
SNOMED-CT56 240637006
MeSH34 D016773
ICD1026 B55.1

Related Diseases for Cutaneous Leishmaniasis

About this section

Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis31.2PGD, IL13, SLC11A1, MT-CYB, MPI, IFNG
2leprosy31.2SLC11A1
3dermatitis30.5IFNG, IL13
4pulmonary tuberculosis30.4IFNG, SLC11A1
5lepromatous leprosy30.3LTA, IFNG
6pulmonary sarcoidosis30.2IFNG, LTA
7visceral leishmaniasis30.2LTA, SLC11A1, PGD, IFNG
8sarcoidosis29.5LTA, SLC11A1, IFNG, FCER2, IL13
9arthritis29.5IL13, FCER2, IFNG, LTA, SLC11A1
10mucocutaneous leishmaniasis10.5
11erysipeloid10.5
12blindness10.4
13paronychia10.3
14granulomatous dermatitis10.3
15iron metabolism disease10.2MT-CYB, SLC11A1
16ankylosing spondylitis10.2
17acquired immunodeficiency syndrome10.2
18panniculitis10.2
19spondylitis10.2
20allergic rhinitis10.2FCER2, IL13
21lipoid nephrosis10.2FCER2, IL13
22pneumonia10.2IL13, MT-CYB
23aspergillosis10.2MT-CYB, IFNG
24bronchiolitis10.2FCER2, IL13
25chronic granulomatous disease10.2IFNG, MT-CYB
26juvenile rheumatoid arthritis10.1SLC11A1, LTA
27bullous pemphigoid10.1IL13, FCER2
28rhinitis10.1FCER2, IL13
29acute graft versus host disease10.1LTA, IFNG
30toxic shock syndrome10.1IFNG, LTA
31schistosomiasis10.1IFNG, IL13
32chromoblastomycosis10.1
33tuberculoid leprosy10.1
34lobomycosis10.1
35follicular mucinosis10.1
36african tick-bite fever10.1
37psoriatic arthritis10.1
38herpes zoster10.1
39necrobiosis lipoidica10.1
40basal cell carcinoma10.1
41blepharitis10.1
42blepharoconjunctivitis10.1
43cellulitis10.1
44ectropion10.1
45elephantiasis10.1
46lagophthalmos10.1
47lupus erythematosus10.1
48lymphopenia10.1
49pericarditis10.1
50trypanosomiasis10.1

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Symptoms for Cutaneous Leishmaniasis

About this section

Drugs & Therapeutics for Cutaneous Leishmaniasis

About this section

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Cutaneous Leishmaniasis

About this section

Anatomical Context for Cutaneous Leishmaniasis

About this section

MalaCards organs/tissues related to Cutaneous Leishmaniasis:

32
Skin, T cells, Monocytes, Testes, Whole blood, Lymph node, Colon, Kidney, Liver, Pancreas, Salivary gland, Nk cells

Animal Models for Cutaneous Leishmaniasis or affiliated genes

About this section

MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4FCER2, IFNG, IL13, SLC11A1
2MP:00053878.1LTA, SLC11A1, IL13, IFNG, FCER2
3MP:00053977.7LTA, SLC11A1, IL13, IFNG, FCER2, MPI
4MP:00107687.6MPI, FCER2, IFNG, IL13, SLC11A1, LTA

Publications for Cutaneous Leishmaniasis

About this section

Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Zosteriform cutaneous leishmaniasis. (25396096)
2014
2
Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof-of-concept for a novel self-administered therapeutic modality. (25363817)
2014
3
Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)
2014
4
Rare variants of cutaneous leishmaniasis presenting as eczematous lesions. (25405136)
2014
5
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
6
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
7
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
8
LeishmaniaA braziliensis-Reactive T Cells Are Down-Regulated in Long-Term Cured Cutaneous Leishmaniasis, but the Renewal Capacity of T Effector Memory Compartments Is Preserved. (24303052)
2013
9
Leishmanicidal activity of amphotericin B encapsulated in PLGA-DMSA nanoparticles to treat cutaneous leishmaniasis in C57BL/6 mice. (23891944)
2013
10
Cluster of zoonotic cutaneous leishmaniasis (Leishmania major) in European travelers returning from Turkmenistan. (24165385)
2013
11
Cutaneous leishmaniasis with unusual clinical and histological presentation: report of four cases. (23690110)
2013
12
Molecular characterization of leishmania infection from naturally infected sand flies caught in a focus of cutaneous leishmaniasis (eastern iran). (24409437)
2013
13
Simultaneous infection with Leishmania (Viannia) braziliensis and L. (V.) lainsoni in a Peruvian patient with cutaneous leishmaniasis. (23382155)
2013
14
Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis. (23390069)
2013
15
Travelers with cutaneous leishmaniasis cured without systemic therapy. (23633111)
2013
16
Sandflies (Diptera: Psychodidae) in rural and urban environments in an endemic area of cutaneous leishmaniasis in southern Brazil. (23778669)
2013
17
Cutaneous leishmaniasis in Al Hassa, Saudi Arabia: epidemiological trends from 2000 to 2010. (23790342)
2013
18
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
19
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
20
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
21
Cutaneous leishmaniasis acquired in Jura, France. (22257720)
2012
22
Correlation of clinical, parasitological and histopathological diagnosis of cutaneous leishmaniasis in an endemic region in Sri Lanka. (23292056)
2012
23
Latency time in cutaneous leishmaniasis. (21505401)
2011
24
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
25
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
26
Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis. (21747837)
2011
27
Lupoid cutaneous leishmaniasis: a case report. (22984663)
2011
28
An outbreak of suspected cutaneous leishmaniasis in Ghana: lessons learnt and preparation for future outbreaks. (21765823)
2011
29
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
30
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
31
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
32
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
33
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
34
Cutaneous leishmaniasis of the lid: a report of nine cases. (20157413)
2010
35
Eight cases of feline cutaneous leishmaniasis in Texas. (20826847)
2010
36
Evaluation of intralesional 0.2% ciprofloxacin as a treatment for cutaneous leishmaniasis. (20214164)
2010
37
The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. (20493664)
2010
38
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. (20854864)
2010
39
Molecular characterization of Leishmania species isolated from cutaneous leishmaniasis in Yemen. (20862227)
2010
40
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
41
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
42
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
43
Evaluation of meglumine antimoniate effects on liver, kidney and pancreas function tests in patients with cutaneous leishmaniasis. (17951131)
2007
44
Ocular involvement in cutaneous leishmaniasis four cases with blepharoconjunctivitis. (15117121)
2004
45
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
46
The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis. (9951957)
1999
47
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
48
Anergic cutaneous leishmaniasis versus lobomycosis. (8737881)
1996
49
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
50
Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. (8132347)
1994

Variations for Cutaneous Leishmaniasis

About this section

Expression for genes affiliated with Cutaneous Leishmaniasis

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Cutaneous Leishmaniasis patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CXCL9chemokine (C-X-C motif) ligand 9Skin+6.420.000
2CXCL10chemokine (C-X-C motif) ligand 10Skin+6.160.000
3IDO1indoleamine 2,3-dioxygenase 1Skin+5.970.000
4GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Skin+5.880.000
5GBP5guanylate binding protein 5Skin+5.820.000
6PIPprolactin-induced proteinSkin-5.800.000
7GNLYgranulysinSkin+5.770.000
8MMP1matrix metallopeptidase 1 (interstitial collagenase)Skin+5.470.000
9DCDdermcidinSkin-5.360.000
10GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)Skin+5.300.000
11SCGB1D2secretoglobin, family 1D, member 2Skin-5.140.000
12CCL8chemokine (C-C motif) ligand 8Skin+5.010.000
13NKG7natural killer cell granule protein 7Skin+4.990.000
14GZMKgranzyme K (granzyme 3; tryptase II)Skin+4.890.000
15SCGB2A2secretoglobin, family 2A, member 2Skin-4.870.000
16IGLL1immunoglobulin lambda-like polypeptide 1Skin+4.820.000
17CCL5chemokine (C-C motif) ligand 5Skin+4.780.000
18MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Skin+4.690.000
19CCL3L3chemokine (C-C motif) ligand 3-like 3Skin+4.670.000
20UBDubiquitin DSkin+4.670.000
21ADAMDEC1ADAM-like, decysin 1Skin+4.650.000
22EPSTI1epithelial stromal interaction 1 (breast)Skin+4.530.000
23IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesSkin+4.530.000
24C5orf46chromosome 5 open reading frame 46Skin-4.530.000
25C1QBcomplement component 1, q subcomponent, B chainSkin+4.510.000
26GZMHgranzyme H (cathepsin G-like 2, protein h-CCPX)Skin+4.480.000
27GBP1guanylate binding protein 1, interferon-inducibleSkin+4.450.000
28CCL4L2chemokine (C-C motif) ligand 4-like 2Skin+4.440.000
29MED27mediator complex subunit 27Skin-4.310.000
30FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptideSkin+4.290.000
31KIR2DL3killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3Skin+4.270.000
32SERPINA12serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12Skin-4.250.000
33GBP4guanylate binding protein 4Skin+4.230.000
34CD8ACD8a moleculeSkin+4.230.000
35TDO2tryptophan 2,3-dioxygenaseSkin+4.190.000
36FCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64)Skin+4.170.000
37IL8interleukin 8Skin+4.130.000
38KRT27keratin 27Skin-4.130.000
39DAPL1death associated protein-like 1Skin-4.100.000
40LYZlysozymeSkin+4.100.000
41THRSPthyroid hormone responsiveSkin-4.060.000
42CHP2calcineurin-like EF-hand protein 2Skin-4.030.000
43PRF1perforin 1 (pore forming protein)Skin+4.030.000
44LAG3lymphocyte-activation gene 3Skin+3.990.000
45CYBBcytochrome b-245, beta polypeptideSkin+3.980.000
46WARStryptophanyl-tRNA synthetaseSkin+3.980.000
47CD3DCD3d molecule, delta (CD3-TCR complex)Skin+3.970.000
48IL18BPinterleukin 18 binding proteinSkin+3.960.000
49SNX10sorting nexin 10Skin+3.960.000
50SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1Skin+3.950.000
51FLG2filaggrin family member 2Skin-3.940.000
52RARRES3retinoic acid receptor responder (tazarotene induced) 3Skin+3.940.000
53IL1Binterleukin 1, betaSkin+3.930.000
54FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Skin+3.920.000
55KRT25keratin 25Skin-3.910.000
56S100A7AS100 calcium binding protein A7ASkin+3.910.000
57SLAMF8SLAM family member 8Skin+3.870.000
58PLEKpleckstrinSkin+3.870.000
59C1QCcomplement component 1, q subcomponent, C chainSkin+3.860.000
60KIR2DL4killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4Skin+3.850.000
61CD38CD38 moleculeSkin+3.850.000
62CD2CD2 moleculeSkin+3.840.000
63MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Skin+3.840.000
64STAT1signal transducer and activator of transcription 1, 91kDaSkin+3.840.000
65KRT15keratin 15Skin-3.830.000
66CXCL11chemokine (C-X-C motif) ligand 11Skin+3.800.000
67CD7CD7 moleculeSkin+3.800.000
68IFI30interferon, gamma-inducible protein 30Skin+3.770.000
69CD247CD247 moleculeSkin+3.750.000
70CD48CD48 moleculeSkin+3.740.000
71SOD2superoxide dismutase 2, mitochondrialSkin+3.730.000
72LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4Skin+3.720.000
73ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1Skin-3.680.000
74SLC7A7solute carrier family 7 (amino acid transporter light chain, y+L system), member 7Skin+3.650.000
75SCGB2A1secretoglobin, family 2A, member 1Skin-3.650.000
76IGLL3Pimmunoglobulin lambda-like polypeptide 3, pseudogeneSkin+3.640.000
77IFNGinterferon, gammaSkin+3.640.000
78MT1Hmetallothionein 1HSkin+3.630.000
79SIGLEC10sialic acid binding Ig-like lectin 10Skin+3.630.000
80ISG15ISG15 ubiquitin-like modifierSkin+3.620.000
81LAPTM5lysosomal protein transmembrane 5Skin+3.620.000
82S100A7S100 calcium binding protein A7Skin+3.620.000
83IL7Rinterleukin 7 receptorSkin+3.610.000
84TLR8toll-like receptor 8Skin+3.610.000
85LCE5Alate cornified envelope 5ASkin-3.570.000
86PLAC8placenta-specific 8Skin+3.570.000
87FNDC1fibronectin type III domain containing 1Skin+3.550.000
88KRT77keratin 77Skin-3.540.000
89TGM2transglutaminase 2Skin+3.540.000
90LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Skin+3.530.000
91VSIG8V-set and immunoglobulin domain containing 8Skin-3.530.000
92SPRR2Asmall proline-rich protein 2ASkin+3.530.000
93CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Skin+3.500.000
94CD163CD163 moleculeSkin+3.500.000
95CD53CD53 moleculeSkin+3.490.000
96OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaSkin+3.490.000
97CCL4L1chemokine (C-C motif) ligand 4-like 1Skin+3.470.000
98KYNUkynureninaseSkin+3.470.000
99TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSkin+3.460.000
100IL4I1interleukin 4 induced 1Skin+3.440.000
101TNFAIP6tumor necrosis factor, alpha-induced protein 6Skin+3.440.000
102SRGNserglycinSkin+3.440.000
103EOMESeomesoderminSkin+3.420.000
104SPP1secreted phosphoprotein 1Skin+3.400.000
105CD14CD14 moleculeSkin+3.390.000
106IL32interleukin 32Skin+3.390.000
107IFI6interferon, alpha-inducible protein 6Skin+3.390.000
108S100A9S100 calcium binding protein A9Skin+3.370.000
109PVRIGpoliovirus receptor related immunoglobulin domain containingSkin+3.350.000
110LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3Skin+3.340.000
111FAM26Ffamily with sequence similarity 26, member FSkin+3.330.000
112CXCR6chemokine (C-X-C motif) receptor 6Skin+3.330.000
113RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Skin+3.320.000
114SULF1sulfatase 1Skin+3.310.000
115IL37interleukin 37Skin-3.310.000
116LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3Skin+3.300.000
117CCR7chemokine (C-C motif) receptor 7Skin+3.290.000
118CORO1Acoronin, actin binding protein, 1ASkin+3.290.000
119AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Skin+3.290.000
120FPR1formyl peptide receptor 1Skin+3.280.000
121SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Skin+3.270.000
122CTLA4cytotoxic T-lymphocyte-associated protein 4Skin+3.270.000
123TYROBPTYRO protein tyrosine kinase binding proteinSkin+3.270.000
124IRF1interferon regulatory factor 1Skin+3.260.000
125MYO1Gmyosin IGSkin+3.260.000
126CD69CD69 moleculeSkin+3.260.000
127C2complement component 2Skin+3.240.000
128ACSBG1acyl-CoA synthetase bubblegum family member 1Skin-3.240.000
129IFIT3interferon-induced protein with tetratricopeptide repeats 3Skin+3.230.000
130SLC2A6solute carrier family 2 (facilitated glucose transporter), member 6Skin+3.220.000
131TSPAN8tetraspanin 8Skin-3.210.000
132IRF8interferon regulatory factor 8Skin+3.210.000
133TNFRSF19tumor necrosis factor receptor superfamily, member 19Skin-3.200.000
134CYBAcytochrome b-245, alpha polypeptideSkin+3.200.000
135FYBFYN binding proteinSkin+3.200.000
136KLRD1killer cell lectin-like receptor subfamily D, member 1Skin+3.180.000
137FABP7fatty acid binding protein 7, brainSkin-3.170.000
138CTSScathepsin SSkin+3.160.000
139FPR3formyl peptide receptor 3Skin+3.160.000
140NCF1Cneutrophil cytosolic factor 1C pseudogeneSkin+3.160.000
141HK3hexokinase 3 (white cell)Skin+3.140.000
142SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1Skin+3.130.000
143CCR1chemokine (C-C motif) receptor 1Skin+3.130.000
144CCL3chemokine (C-C motif) ligand 3Skin+3.130.000
145ISG20interferon stimulated exonuclease gene 20kDaSkin+3.130.000
146HAVCR2hepatitis A virus cellular receptor 2Skin+3.130.000
147SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Skin+3.130.000
148CD6CD6 moleculeSkin+3.120.000
149CTSZcathepsin ZSkin+3.120.000
150SIGLEC14sialic acid binding Ig-like lectin 14Skin+3.110.000
151PI3peptidase inhibitor 3, skin-derivedSkin+3.110.001
152MT4metallothionein 4Skin-3.110.000
153FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)Skin+3.110.000
154IFI44Linterferon-induced protein 44-likeSkin+3.100.000
155PSMB9proteasome (prosome, macropain) subunit, beta type, 9Skin+3.090.000
156DEFB103Bdefensin, beta 103BSkin+3.090.000
157AIF1allograft inflammatory factor 1Skin+3.080.000
158OASL2'-5'-oligoadenylate synthetase-likeSkin+3.080.000
159HCSThematopoietic cell signal transducerSkin+3.080.000
160HCLS1hematopoietic cell-specific Lyn substrate 1Skin+3.070.000
161CD74CD74 molecule, major histocompatibility complex, class II invariant chainSkin+3.070.000
162HAPLN3hyaluronan and proteoglycan link protein 3Skin+3.060.000
163CAMK1Gcalcium/calmodulin-dependent protein kinase IGSkin+3.050.000
164MAMDC2MAM domain containing 2Skin-3.050.000
165TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoySkin+3.050.000
166IL24interleukin 24Skin+3.040.000
167FRZBfrizzled-related proteinSkin-3.040.000
168PLIN4perilipin 4Skin-3.030.001
169HLA-DRB1major histocompatibility complex, class II, DR beta 1Skin+3.030.022
170HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Skin+3.030.000
171ITGAXintegrin, alpha X (complement component 3 receptor 4 subunit)Skin+3.020.000
172PLAURplasminogen activator, urokinase receptorSkin+3.020.000
173IL18RAPinterleukin 18 receptor accessory proteinSkin+3.010.000
174CD52CD52 moleculeSkin+3.010.000
175MMP12matrix metallopeptidase 12 (macrophage elastase)Skin+3.000.001
176CD300LFCD300 molecule-like family member fSkin+3.000.000
177LPXNleupaxinSkin+2.990.000
178SELLselectin LSkin+2.990.000
179DCTdopachrome tautomeraseSkin-2.990.000
180FABP9fatty acid binding protein 9, testisSkin-2.980.000
181FGRfeline Gardner-Rasheed sarcoma viral oncogene homologSkin+2.980.000
182UCP2uncoupling protein 2 (mitochondrial, proton carrier)Skin+2.980.000
183APOBEC3Gapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3GSkin+2.970.000
184RGS1regulator of G-protein signaling 1Skin+2.970.000
185ZNF807zinc finger protein 807Skin-2.970.000
186LOC606724coronin, actin binding protein, 1A pseudogeneSkin+2.960.000
187BST2bone marrow stromal cell antigen 2Skin+2.960.000
188SCELsciellinSkin-2.960.000
189WASWiskott-Aldrich syndromeSkin+2.960.000
190CD96CD96 moleculeSkin+2.960.000
191LTBlymphotoxin beta (TNF superfamily, member 3)Skin+2.960.000
192NCF1neutrophil cytosolic factor 1Skin+2.950.000
193CLDN8claudin 8Skin-2.950.000
194FLGfilaggrinSkin-2.950.002
195KRTAP17-1keratin associated protein 17-1Skin-2.950.001
196TFtransferrinSkin-2.940.000
197FCGR1CFc fragment of IgG, high affinity Ic, receptor (CD64), pseudogeneSkin+2.930.000
198CFBcomplement factor BSkin+2.930.000
199CXCR4chemokine (C-X-C motif) receptor 4Skin+2.930.000
200SH2D1ASH2 domain containing 1ASkin+2.920.000
201AIM2absent in melanoma 2Skin+2.920.000
202MYH11myosin, heavy chain 11, smooth muscleSkin-2.910.000
203IL2RBinterleukin 2 receptor, betaSkin+2.910.000
204HCKhemopoietic cell kinaseSkin+2.910.000
205APOL3apolipoprotein L, 3Skin+2.910.000
206KLRB1killer cell lectin-like receptor subfamily B, member 1Skin+2.900.000
207LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologSkin+2.900.000
208PM20D1peptidase M20 domain containing 1Skin-2.900.001
209MT2Ametallothionein 2ASkin+2.890.000
210MS4A7membrane-spanning 4-domains, subfamily A, member 7Skin+2.890.000
211CD86CD86 moleculeSkin+2.890.000
212PTPRCAPprotein tyrosine phosphatase, receptor type, C-associated proteinSkin+2.890.000
213KRT16keratin 16Skin+2.880.000
214ADAM19ADAM metallopeptidase domain 19Skin+2.880.000
215RSAD2radical S-adenosyl methionine domain containing 2Skin+2.880.000
216NCKAP1LNCK-associated protein 1-likeSkin+2.880.000
217RERGLRERG/RAS-likeSkin-2.870.000
218C2orf82chromosome 2 open reading frame 82Skin-2.870.000
219FERMT3fermitin family member 3Skin+2.870.000
220SLC15A3solute carrier family 15 (oligopeptide transporter), member 3Skin+2.870.000
221CCL3L1chemokine (C-C motif) ligand 3-like 1Skin+2.870.000
222CST6cystatin E/MSkin-2.860.000
223ADH1Aalcohol dehydrogenase 1A (class I), alpha polypeptideSkin-2.860.000
224MAP4K1mitogen-activated protein kinase kinase kinase kinase 1Skin+2.860.000
225IFIT2interferon-induced protein with tetratricopeptide repeats 2Skin+2.850.000
226GALgalanin/GMAP prepropeptideSkin-2.850.001
227S100A8S100 calcium binding protein A8Skin+2.850.000
228CD68CD68 moleculeSkin+2.850.000
229KRT74keratin 74Skin-2.840.000
230TBC1D10CTBC1 domain family, member 10CSkin+2.840.000
231ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)Skin+2.840.000
232FTH1P8ferritin, heavy polypeptide 1 pseudogene 8Skin+2.830.000
233IL6interleukin 6 (interferon, beta 2)Skin+2.830.000
234KRT73keratin 73Skin-2.830.000
235CEMIPcell migration inducing protein, hyaluronan bindingSkin+2.830.000
236SLAMF6SLAM family member 6Skin+2.820.000
237CSF3Rcolony stimulating factor 3 receptor (granulocyte)Skin+2.820.000
238TCHHtrichohyalinSkin-2.820.001
239SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 4Skin+2.820.000
240PON3paraoxonase 3Skin-2.820.000
241SLASrc-like-adaptorSkin+2.820.000
242RASAL3RAS protein activator like 3Skin+2.810.000
243HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)Skin-2.810.000
244PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alphaSkin-2.810.000
245HLA-DRB3major histocompatibility complex, class II, DR beta 3Skin+2.810.000
246GVINP1GTPase, very large interferon inducible pseudogene 1Skin+2.810.000
247SPRR2Fsmall proline-rich protein 2FSkin+2.810.000
248ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Skin+2.800.000
249PNKDparoxysmal nonkinesigenic dyskinesiaSkin+2.800.000
250CLDN10claudin 10Skin-2.800.000
251ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Skin-2.790.000
252ALDH3A1aldehyde dehydrogenase 3 family, member A1Skin-2.790.000
253ELOVL3ELOVL fatty acid elongase 3Skin-2.780.001
254PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1BSkin-2.780.000
255MUCL1mucin-like 1Skin-2.780.000
256LOC645638WDNM1-like pseudogeneSkin-2.770.000
257PSAPL1prosaposin-like 1 (gene/pseudogene)Skin-2.770.000
258CKBcreatine kinase, brainSkin-2.750.000
259PANK1pantothenate kinase 1Skin-2.740.000
260LCE1Blate cornified envelope 1BSkin-2.740.001
261C1orf68chromosome 1 open reading frame 68Skin-2.740.000
262CCL27chemokine (C-C motif) ligand 27Skin-2.730.000
263AZGP1alpha-2-glycoprotein 1, zinc-bindingSkin-2.730.000
264LYPD6BLY6/PLAUR domain containing 6BSkin-2.720.000
265AWAT2acyl-CoA wax alcohol acyltransferase 2Skin-2.720.001
266PAMR1peptidase domain containing associated with muscle regeneration 1Skin-2.720.000
267FOXQ1forkhead box Q1Skin-2.700.000
268MTURNmaturin, neural progenitor differentiation regulator homolog (Xenopus)Skin-2.690.000
269WDR72WD repeat domain 72Skin-2.680.000
270PLLPplasmolipinSkin-2.670.000
271KRT85keratin 85Skin-2.660.001
272LOC284023uncharacterized LOC284023Skin-2.660.000
273COBLcordon-bleu WH2 repeat proteinSkin-2.650.000
274PNLIPRP3pancreatic lipase-related protein 3Skin-2.640.000
275FASNfatty acid synthaseSkin-2.630.000
276CILPcartilage intermediate layer protein, nucleotide pyrophosphohydrolaseSkin-2.620.001
277ALDH3A2aldehyde dehydrogenase 3 family, member A2Skin-2.610.000
278PMELpremelanosome proteinSkin-2.610.000
279CTNNBIP1catenin, beta interacting protein 1Skin-2.600.000
280RHPN2rhophilin, Rho GTPase binding protein 2Skin-2.590.000
281TACC2transforming, acidic coiled-coil containing protein 2Skin-2.580.000
282CLDN1claudin 1Skin-2.580.000
283SLC12A2solute carrier family 12 (sodium/potassium/chloride transporter), member 2Skin-2.570.000
284DSC1desmocollin 1Skin-2.570.001
285EPCAMepithelial cell adhesion moleculeSkin-2.570.000
286MATN2matrilin 2Skin-2.560.000
287CIDECcell death-inducing DFFA-like effector cSkin-2.560.004
288GSTM3glutathione S-transferase mu 3 (brain)Skin-2.550.000
289SH3BGRL2SH3 domain binding glutamate-rich protein like 2Skin-2.540.000
290GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Skin-2.540.000
291AKR1C2aldo-keto reductase family 1, member C2Skin-2.540.000
292CIDEAcell death-inducing DFFA-like effector aSkin-2.490.001
293TYRP1tyrosinase-related protein 1Skin-2.490.001
294DNERdelta/notch-like EGF repeat containingSkin-2.480.000
295ABHD12Babhydrolase domain containing 12BSkin-2.470.000
296MLANAmelan-ASkin-2.470.000
297AHNAK2AHNAK nucleoprotein 2Skin-2.460.000
298MAOAmonoamine oxidase ASkin-2.460.000
299CA6carbonic anhydrase VISkin-2.460.000
300CLEC3BC-type lectin domain family 3, member BSkin-2.450.000
301ALOX15Barachidonate 15-lipoxygenase, type BSkin-2.450.000
302LCE2Dlate cornified envelope 2DSkin-2.440.003
303TMEM99transmembrane protein 99Skin-2.440.000
304DLK2delta-like 2 homolog (Drosophila)Skin-2.430.000
305CORINcorin, serine peptidaseSkin-2.430.000
306KRT71keratin 71Skin-2.420.001
307SOX21SRY (sex determining region Y)-box 21Skin-2.420.000
308TPD52L1tumor protein D52-like 1Skin-2.410.000
309C2orf40chromosome 2 open reading frame 40Skin-2.410.000
310ANGPTL5angiopoietin-like 5Skin-2.390.000
311LCE2Blate cornified envelope 2BSkin-2.380.004
312CRYABcrystallin, alpha BSkin-2.380.000
313SORBS1sorbin and SH3 domain containing 1Skin-2.380.000
314LCE1Clate cornified envelope 1CSkin-2.370.003
315KRT79keratin 79Skin-2.370.002
316KRT19keratin 19Skin-2.370.000
317TCEA3transcription elongation factor A (SII), 3Skin-2.360.000
318CLEC2AC-type lectin domain family 2, member ASkin-2.360.000
319DHCR2424-dehydrocholesterol reductaseSkin-2.350.000
320CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 2Skin-2.340.000
321SCARA5scavenger receptor class A, member 5 (putative)Skin-2.340.000
322ELMOD1ELMO/CED-12 domain containing 1Skin-2.330.000
323CGNL1cingulin-like 1Skin-2.320.000
324SYNGR1synaptogyrin 1Skin-2.310.000
325IGFL2IGF-like family member 2Skin-2.300.000
326PCP4Purkinje cell protein 4Skin-2.300.000
327VTCN1V-set domain containing T cell activation inhibitor 1Skin-2.300.000
328SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1Skin-2.290.001
329EPHB6EPH receptor B6Skin-2.290.000
330KRT35keratin 35Skin-2.280.001
331GPTglutamic-pyruvate transaminase (alanine aminotransferase)Skin-2.280.000
332MGST1microsomal glutathione S-transferase 1Skin-2.280.001
333RAPGEFL1Rap guanine nucleotide exchange factor (GEF)-like 1Skin-2.280.000
334C9orf152chromosome 9 open reading frame 152Skin-2.270.000
335NDRG2NDRG family member 2Skin-2.270.000
336AADACL2arylacetamide deacetylase-like 2Skin-2.270.003
337CYP4X1cytochrome P450, family 4, subfamily X, polypeptide 1Skin-2.250.000
338NMUneuromedin USkin-2.250.000
339SOX9SRY (sex determining region Y)-box 9Skin-2.240.000
340FAM189A2family with sequence similarity 189, member A2Skin-2.240.000
341FAXDC2fatty acid hydroxylase domain containing 2Skin-2.240.000
342PHGDHphosphoglycerate dehydrogenaseSkin-2.230.000
343ELOVL4ELOVL fatty acid elongase 4Skin-2.230.000
344KRT31keratin 31Skin-2.220.000
345FHL1four and a half LIM domains 1Skin-2.220.000
346CDHR1cadherin-related family member 1Skin-2.210.000
347TPPP3tubulin polymerization-promoting protein family member 3Skin-2.200.000
348CFDcomplement factor D (adipsin)Skin-2.200.000
349DSPdesmoplakinSkin-2.200.000
350MSMBmicroseminoprotein, beta-Skin-2.190.000
351KRTAP26-1keratin associated protein 26-1Skin-2.180.007
352HES5hes family bHLH transcription factor 5Skin-2.180.000
353IL17Dinterleukin 17DSkin-2.180.000
354LCE6Alate cornified envelope 6ASkin-2.180.009
355FGFR3fibroblast growth factor receptor 3Skin-2.170.001
356CAPNS2calpain, small subunit 2Skin-2.170.000
357AHNAKAHNAK nucleoproteinSkin-2.170.000
358IL20RBinterleukin 20 receptor betaSkin-2.170.000
359FABP4fatty acid binding protein 4, adipocyteSkin-2.160.049
360KRT72keratin 72Skin-2.140.000
361CLCA4chloride channel accessory 4Skin-2.140.001
362CTDSPLCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-likeSkin-2.140.000
363KRT2keratin 2Skin-2.130.033
364FOXC1forkhead box C1Skin-2.130.000
365PCOLCE2procollagen C-endopeptidase enhancer 2Skin-2.120.003
366TMEM254transmembrane protein 254Skin-2.110.000
367MUC7mucin 7, secretedSkin-2.110.000
368ANKRD35ankyrin repeat domain 35Skin-2.110.000
369ZNF750zinc finger protein 750Skin-2.110.000
370KLC3kinesin light chain 3Skin-2.100.000
371SERTAD4SERTA domain containing 4Skin-2.100.000
372ROPN1rhophilin associated tail protein 1Skin-2.100.000
373RORARAR-related orphan receptor ASkin-2.100.000
374BCHEbutyrylcholinesteraseSkin-2.090.000
375HSD11B2hydroxysteroid (11-beta) dehydrogenase 2Skin-2.090.000
376PDZD2PDZ domain containing 2Skin-2.080.000
377KRTAP11-1keratin associated protein 11-1Skin-2.080.020
378FAM167Afamily with sequence similarity 167, member ASkin-2.080.000
379BTBD16BTB (POZ) domain containing 16Skin-2.070.000
380LOC441052uncharacterized LOC441052Skin-2.070.003
381GJB4gap junction protein, beta 4, 30.3kDaSkin-2.070.000
382LCE1Alate cornified envelope 1ASkin-2.070.016
383GABRPgamma-aminobutyric acid (GABA) A receptor, piSkin-2.070.000
384EVPLenvoplakinSkin-2.060.000
385HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)Skin-2.060.000
386DGAT2diacylglycerol O-acyltransferase 2Skin-2.060.000
387GSTO2glutathione S-transferase omega 2Skin-2.060.000
388GGT6gamma-glutamyltransferase 6Skin-2.060.000
389SOSTDC1sclerostin domain containing 1Skin-2.060.000
390AACSacetoacetyl-CoA synthetaseSkin-2.050.000
391GPRC5CG protein-coupled receptor, class C, group 5, member CSkin-2.050.000
392ADIRFadipogenesis regulatory factorSkin-2.050.000
393ROPN1Brhophilin associated tail protein 1BSkin-2.050.000
394NMNAT3nicotinamide nucleotide adenylyltransferase 3Skin-2.040.000
395ERBB3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3Skin-2.040.000
396C1orf116chromosome 1 open reading frame 116Skin-2.040.000
397IL20RAinterleukin 20 receptor, alphaSkin-2.040.000
398ISM1isthmin 1, angiogenesis inhibitorSkin-2.040.000
399FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideSkin-2.030.007
400NOVnephroblastoma overexpressedSkin-2.030.000

Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

Search GEO for disease gene expression data for Cutaneous Leishmaniasis.

Pathways for genes affiliated with Cutaneous Leishmaniasis

About this section

Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4LTA, FCER2
29.4IL13, IFNG
39.4IL13, IFNG
49.4IFNG, IL13
5
Show member pathways
9.3LTA, IFNG
6
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.3LTA, IFNG
7
Show member pathways
IL27-mediated signaling events37
9.3IFNG, LTA
88.8LTA, IL13, IFNG
9
Show member pathways
8.8LTA, IL13, IFNG
108.8LTA, IL13, IFNG
11
Show member pathways
8.8LTA, IL13, IFNG
12
Show member pathways
8.4FCER2, IFNG, IL13, LTA

Compounds for genes affiliated with Cutaneous Leishmaniasis

About this section

Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1fe2+449.9MT-CYB, SLC11A1
2alpha-galactosylceramide449.8IL13, IFNG
3glatiramer acetate44 1210.8IL13, IFNG
4pirfenidone44 6010.8IL13, IFNG
5amphotericin b449.8IL13, IFNG
6il-12449.8IFNG, IL13
7indoleamine449.8IFNG, IL13
8nickel44 2510.7IL13, SLC11A1
96-phosphogluconate449.7MPI, PGD
10fumarate44 1210.6IFNG, MT-CYB, MPI
11gm-csf44 2910.6IFNG, IL13
12budesonide44 50 1211.6IFNG, IL13
13cellulose acetate449.6MPI, PGD
14isocitrate449.5MPI, PGD
15nadp+449.5MT-CYB, PGD
16allergens449.4IL13, IFNG, FCER2
17hydrocortisone44 3 60 1212.4FCER2, IFNG, IL13
18okt3449.4LTA, IFNG, FCER2
19neopterin449.3FCER2, IFNG, LTA
20fluticasone propionate44 50 60 1212.3IL13, IFNG
21herbimycin a44 6010.3LTA, IFNG, FCER2
22sb 20358044 6010.3FCER2, IFNG, IL13
23glyceraldehyde 3-phosphate449.2MPI, PGD, MT-CYB
24salbutamol44 50 29 25 1213.2IL13, FCER2
25il 10449.2IFNG, IL13, LTA
26pentoxifylline44 1210.2LTA, IL13, IFNG
27prednisolone44 29 1211.2LTA, IL13, IFNG
28endotoxin449.2LTA, IL13, IFNG
29rantes449.1LTA, IL13, IFNG
30indomethacin44 29 60 1212.1LTA, IL13, IFNG
31histamine44 29 2511.0FCER2, IFNG, IL13
32thymidine44 2510.0FCER2, MT-CYB, IFNG, IL13
33fmlp448.9LTA, IL13, MT-CYB, FCER2
34superoxide44 259.9MPI, FCER2, PGD, MT-CYB
35ionomycin448.8FCER2, IFNG, IL13, LTA
36calcitriol44 60 25 1211.8FCER2, IFNG, IL13, LTA
37pge2448.8FCER2, IFNG, IL13, LTA
38threonine448.8LTA, IL13, MT-CYB, FCER2
39dexamethasone44 50 29 1211.8LTA, IL13, IFNG, FCER2
40mannose448.7MPI, FCER2, IL13, SLC11A1, LTA
41lactate448.5LTA, IL13, PGD, FCER2
42retinoic acid44 259.5LTA, IL13, IFNG, FCER2
43aspartate448.5MPI, PGD, MT-CYB, IL13, SLC11A1
44oxygen44 259.5LTA, SLC11A1, MT-CYB, PGD
45serine448.4FCER2, FCN2, MT-CYB, IL13, LTA
46h2o2448.4PGD, MT-CYB, IL13, LTA
47cycloheximide448.4FCER2, MT-CYB, IFNG, IL13, LTA
48glutamate448.4PGD, MT-CYB, IL13, LTA
49glucose448.3LTA, MT-CYB, PGD, MPI
50nitric oxide44 25 129.2LTA, SLC11A1, IL13, IFNG, MT-CYB, PGD

GO Terms for genes affiliated with Cutaneous Leishmaniasis

About this section

Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IFNG, FCER2

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of killing of cells of other organismGO:0517129.7IFNG, FCER2
2defense response to protozoanGO:0428329.7IFNG, SLC11A1
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, FCER2
4protein import into nucleus, translocationGO:0000609.6SLC11A1, IFNG
5negative regulation of growth of symbiont in hostGO:0441309.4LTA, IFNG
6cellular component movementGO:0069289.4IL13, IFNG
7positive regulation of interferon-gamma productionGO:0327299.4LTA, SLC11A1
8response to lipopolysaccharideGO:0324969.1IL13, SLC11A1, LTA
9humoral immune responseGO:0069599.0LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8LTA, IL13, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Cutaneous Leishmaniasis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet