MCID: CTN007
MIFTS: 55

Cutaneous Leishmaniasis malady

Infectious category

Summaries for Cutaneous Leishmaniasis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to visceral leishmaniasis and lepromatous leprosy. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are Pentose phosphate pathway (hexose monophosphate shunt) and Pentose Phosphate Pathway (Erythrocyte). The drug meglumine and the compounds cycloheximide and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 35MeSH, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

cutaneous leishmaniasis 8 10
asian desert cutaneous leishmaniasis 8 61
diffuse cutaneous leishmaniasis 8 61
ethiopian cutaneous leishmaniasis 61
leishmaniasis diffuse cutaneous 45
leishmaniasis, cutaneous 61
leishmaniasis cutaneous 45
leproid leishmaniasis 8


External Ids:

Disease Ontology8 DOID:9111
MeSH35 D016773
SNOMED-CT57 240637006
NCIt40 C34768
ICD1025 B55.1

Related Diseases for Cutaneous Leishmaniasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1visceral leishmaniasis30.9IFNG, LTA, PGD, IL4, LMLN, SLC11A1
2lepromatous leprosy30.0IFNG, LTA, IL4
3pulmonary tuberculosis30.0SLC11A1, IL4, IFNG
4tuberculosis30.0SLC11A1, PNP, IFNG, TNFRSF8, MDH2, IL4
5arthritis30.0IFNG, FOXP3, LTA, IL13, IL4, FCER2
6erysipeloid10.4
7mucocutaneous leishmaniasis10.4
8granulomatous dermatitis10.3
9paronychia10.2
10ankylosing spondylitis10.2
11acquired immunodeficiency syndrome10.2
12spondylitis10.2
13lobomycosis10.0
14mechanical lagophthalmos10.0
15chromoblastomycosis10.0
16cutaneous lupus erythematosus10.0
17pulmonary sarcoidosis10.0
18cellulitis10.0
19psoriatic arthritis10.0
20tuberculoid leprosy10.0
21follicular mucinosis10.0
22herpes zoster10.0
23african tick-bite fever10.0
24basal cell carcinoma10.0
25blepharitis10.0
26blepharoconjunctivitis10.0
27squamous cell carcinoma10.0
28trypanosomiasis10.0
29yaws10.0
30mycobacterium marinum10.0
31discoid lupus erythematosus10.0
32hepatitis10.0LTA
33nephrotic syndrome10.0IL13
34leprosy10.0SLC11A1
35sjogren's syndrome10.0GZMA
36kawasaki disease10.0FCER2
37vitiligo10.0G6PD
38typhoid fever10.0SLC11A1
39brucellosis10.0SLC11A1
40myopathy10.0MT-CYB
41pneumonia10.0MT-CYB, IL13
42chagas disease10.0MT-CYB
43bronchiolitis10.0FCER2, IL13
44inflammatory bowel disease10.0FOXP3
45kidney cancer10.0FH
46primary immunodeficiency disease10.0PNP
47toxic shock syndrome10.0IFNG, LTA
48candidiasis10.0IFNG
49polymyositis10.0GZMA
50hypersensitivity reaction type ii disease10.0FOXP3, IL4

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Clinical Features for Cutaneous Leishmaniasis

Drugs & Therapeutics for Cutaneous Leishmaniasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cutaneous Leishmaniasis

Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Search CenterWatch for Cutaneous Leishmaniasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cutaneous Leishmaniasis

Anatomical Context for Cutaneous Leishmaniasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cutaneous Leishmaniasis:

33
Skin, Liver, Kidney, Lymph node, Whole blood, Colon, Pancreas, Salivary gland, Monocytes, T cells, B cells, Endothelial

Animal Models for Cutaneous Leishmaniasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.0GZMA, TNFRSF8, FOXP3, LTA, IL13, IL4
2MP:00053979.9SLC11A1, IFNG, GZMA, TNFRSF8, FOXP3, G6PD
3MP:00107689.7G6PD, FOXP3, FH, GZMA, IFNG, MPI

Publications for Cutaneous Leishmaniasis

Sources:
51PubMed
See all sources

Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 650)
idTitleAuthorsYear
1
Outbreak of cutaneous leishmaniasis in Fuenlabrada, Madrid. (23567452)
2013
2
Contribution of molecular diagnosis to the management of cutaneous leishmaniasis in travellers. (24279601)
2013
3
Exploring recent spatial patterns of cutaneous leishmaniasis and their associations with climate in some countries of the Middle East using geographical information systems. (24258891)
2013
4
Clinical and Immunological Analysis of Cutaneous Leishmaniasis before and after Different Treatments. (23844278)
2013
5
Epidemiologic study and molecular detection of Leishmania and sand fly species responsible of cutaneous leishmaniasis in Foum JamAca (Azilal, Atlas of Morocco). (23524126)
2013
6
Clinical and histopathological characteristics of cutaneous Leishmaniasis in Sanliurfa City of Turkey including Syrian refugees. (24152496)
2013
7
Expression of Foxp3, TGF-I^ and IL-10 in American cutaneous leishmaniasis lesions. (23922083)
2013
8
Case report: Transient success using prolonged treatment with miltefosine for a patient with diffuse cutaneous leishmaniasis infected with Leishmania mexicana mexicana. (23243111)
2013
9
Detection of DNA from Leishmania (Viannia): accuracy of polymerase chain reaction for the diagnosis of cutaneous leishmaniasis. (23976920)
2013
10
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
11
First case of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Suriname. (22556081)
2012
12
Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis. (22615508)
2012
13
Treatment response of cutaneous leishmaniasis due to Leishmania aethiopica to cryotherapy and generic sodium stibogluconate from patients in Silti, Ethiopia. (22503475)
2012
14
Auricular cutaneous leishmaniasis mimicking neoplastic disease. (22704524)
2012
15
Adverse effects of intralesional meglumine antimoniate and its influence on clinical laboratory parameters in the treatment of cutaneous leishmaniasis. (22994669)
2012
16
Monitoring toxicity associated with parenteral sodium stibogluconate in the day-case management of returned travellers with New World cutaneous leishmaniasis [corrected]. (22745840)
2012
17
Leishmania (Viannia) shawi purified antigens confer protection against murine cutaneous leishmaniasis. (22166919)
2012
18
Comparison among three polymerase chain reaction assays on detection of DNA from Leishmania in biological samples from patients with American cutaneous leishmaniasis. (22535003)
2012
19
The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis. (21987238)
2012
20
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
21
Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis. (21747837)
2011
22
Human cutaneous leishmaniasis: interferon-dependent expression of double-stranded RNA-dependent protein kinase (PKR) via TLR2. (21846836)
2011
23
Renal tubular dysfunction in patients with American cutaneous leishmaniasis. (21814169)
2011
24
Diagnostic performance of filter paper lesion impression PCR for secondarily infected ulcers and nonulcerative lesions caused by cutaneous leishmaniasis. (21177908)
2011
25
Accelerated healing of cutaneous leishmaniasis in non-healing BALB/c mice using water soluble amphotericin B-polymethacrylic acid. (21807409)
2011
26
Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy. (21950631)
2011
27
Glucantime efficacy in the treatment of zoonotic cutaneous leishmaniasis. (21706927)
2011
28
Visceral leishmaniasis in a patient with cutaneous lesions, negative Leishman-Donovan bodies and immunological test: A case report. (22973355)
2011
29
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
30
CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. (20089160)
2010
31
The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. (20430117)
2010
32
Efficacy of short-duration (twice weekly) intralesional sodium stibogluconate in treatment of cutaneous Leishmaniasis in India. (20500797)
2010
33
Isoenzyme electrophetic characterization of Leishmania major, the causative agent of zoonotic cutaneous Leishmaniasis in North and West Saudi Arabia. (21246954)
2010
34
Lack of association of Toll-Like Receptor 2 Arg753Gln with cutaneous leishmaniasis. (20388552)
2010
35
Cutaneous leishmaniasis (Leishmania major infection) in Dutch troops deployed in northern Afghanistan: epidemiology, clinical aspects, and treatment. (21118937)
2010
36
Therapeutic effect of sodium selenite and zinc sulphate as supplementary with meglumine antimoniate( glucantimeAr) against cutaneous leishmaniasis in BALB/c mice. (22347250)
2010
37
Management of old world cutaneous leishmaniasis in refugee children. (19952859)
2010
38
Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. (19168733)
2009
39
Genus-specific kinetoplast-DNA PCR and parasite culture for the diagnosis of localised cutaneous leishmaniasis: applications for clinical trials under field conditions in Brazil. (20027466)
2009
40
Plasma sCD26 and sCD30 levels in cutaneous leishmaniasis. (18983807)
2009
41
American cutaneous leishmaniasis in the Pontal of Paranapanema - SP, Brazil: ecological and entomological aspects. (19893981)
2009
42
Efficacy of Olyset long-lasting bednets to control transmission of cutaneous leishmaniasis in Iran. (20214120)
2009
43
CD8 cytotoxic T cells in cutaneous leishmaniasis. (18042173)
2007
44
Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis. (17241668)
2007
45
Effect of LACK and KMP11 on IFN-gamma production by peripheral blood mononuclear cells from cutaneous and mucosal leishmaniasis patients. (15853916)
2005
46
Evaluation of In Vitro Production of IFN-gamma, IL-10, IL-12 and IL-13 by Blood Cells in Patients with Cutaneous Leishmaniasis Lesions. (17301418)
2005
47
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
48
Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. (8132347)
1994
49
Mycobacterium marinum skin infections mimicking cutaneous leishmaniasis. (1268057)
1976
50
Leishmaniasis in Brazil: X. Some observations of intradermal reactions to different trypanosomatid antigens of patients suffering from cutaneous and mucocutaneous leishmaniasis. (52214)
1975

Genetic Variations for Cutaneous Leishmaniasis

Expression for genes affiliated with Cutaneous Leishmaniasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

Search GEO for disease gene expression data for Cutaneous Leishmaniasis.

Pathways for genes affiliated with Cutaneous Leishmaniasis

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 53R&D Systems, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4PGD, G6PD
2
Hide members
10.4PGD, G6PD
310.4IL4, IL13
4
Hide members
10.4IL13, TNFRSF8
510.4IL4, IL13, IFNG
6
Hide members
10.4IL4, FOXP3, IFNG
7
Hide members
10.4IL4, LTA, FOXP3
810.3LTA, IL4, FCER2
9
Hide members
10.3FOXP3, GZMA, IFNG
10
Hide members
10.3IFNG, GZMA, IL4
11
Hide members
10.3IL4, IL13, LTA, IFNG
1210.3IL4, IL13, LTA, IFNG
13
Hide members
10.3IFNG, LTA, IL13, IL4
1410.3IFNG, LTA, IL13, IL4
15
Hide members
10.3IFNG, FOXP3, IL13, IL4
16
Hide members
10.3IFNG, IL13, IL4, FCER2
1710.3FH, G6PD, MDH2, PGD

Compounds for genes affiliated with Cutaneous Leishmaniasis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7LMLN, LTA, MT-CYB
2alpha-galactosylceramide4510.7IL4, IL13, IFNG
3amphotericin b4510.7IL13
4fumarate45 1111.7MT-CYB, MPI, G6PD, FH, IFNG
5okt34510.7IFNG, LTA, IL4, FCER2
6nadp+4510.7PGD, MT-CYB, MDH2, G6PD
7cellulose acetate4510.7G6PD, MDH2, MPI, PGD
8pentoxifylline45 1111.7LTA, IL13, IL4
9il 104510.7IFNG, LTA, IL13, IL4
106-phosphogluconate4510.7FH, G6PD, MDH2, MPI, PGD
11isocitrate4510.7FH, G6PD, MDH2, MPI, PGD
12hypoxanthine45 11 2412.7G6PD, PGD, IL4, PNP
13glatiramer acetate45 1111.7IL4, IL13, IFNG
14glucose 6-phosphate45 2411.7FH, G6PD, MDH2, MPI, PGD
15nad+4510.7FH, G6PD, MDH2, MT-CYB, PGD
16ribavirin45 50 1112.7PNP, IL4, G6PD, IFNG
17hydrocortisone45 2 60 1113.7FCER2
18mannose4510.7MPI, LTA, IL13, FCER2, SLC11A1
19neopterin4510.7IFNG, LTA, IL4, FCER2
206-phosphogluconolactone4510.7PGD, G6PD
21glucose4510.7PNP, PGD, MPI, MDH2
22nucleoside4510.7FH, MDH2, MPI, PGD, PNP
23malate4510.7FH, G6PD, MDH2, MPI, PGD, PNP
24glyceraldehyde 3-phosphate4510.7G6PD, MDH2, MPI, MT-CYB, PGD, PNP
25ionomycin4510.7IFNG, GZMA, LTA, IL13, IL4, FCER2
26allergens4510.7IFNG, IL13, IL4, FCER2
27il-124510.7IFNG, IL13, IL4
28succinate4510.6MT-CYB, MDH2, G6PD, FH
29prpp4510.6G6PD, PGD, PNP
30calcitriol45 60 11 2413.6IFNG, LTA, IL13, IL4, FCER2
31rantes4510.6IFNG, GZMA, LTA, IL4
32cyclosporin a45 29 6012.6IFNG, GZMA, TNFRSF8, FOXP3, LTA, IL13
33serine4510.6G6PD, MT-CYB, LTA, IL13, FCER2
34thymidine45 2411.6IFNG, TNFRSF8, MT-CYB, IL13, IL4, FCER2
35nitric oxide45 11 2412.6IFNG, FOXP3, MT-CYB, LTA, PGD, IL13
36superoxide45 2411.6GZMA, FH, G6PD, MDH2, MPI, MT-CYB
37starch4510.6MPI, MDH2, G6PD
38lactate4510.6FH, G6PD, MDH2, LTA, PGD, IL13
39h2o24510.6G6PD, MDH2, MT-CYB, LTA, PGD, IL13
40aspartate4510.5FH, G6PD, MDH2, MPI, MT-CYB, PGD
41oxazolone4510.5IL4, IL13
42nadh45 11 2412.5FH, G6PD, MDH2, MT-CYB, PGD
436-aminonicotinamide4510.5PGD, G6PD
44oxygen45 2411.5GZMA, FH, MT-CYB, SLC11A1
45gm-csf45 2911.4IFNG
46phenazine methosulfate4510.4MDH2, G6PD
47budesonide45 50 1112.4IL4, IL13, IFNG
48atp45 2911.3FH, G6PD, MDH2, MT-CYB, PGD, FCER2
49citrate4510.2PGD, MDH2, G6PD, FH
50cysteine459.9IFNG, GZMA, IL13, IL4, LMLN, FCER2

GO Terms for genes affiliated with Cutaneous Leishmaniasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.3FCER2, IL4, IL13, IFNG

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1pentose biosynthetic processGO:01932210.7PGD, G6PD
2positive regulation of killing of cells of other organismGO:05171210.7IFNG, FCER2
3pentose-phosphate shunt, oxidative branchGO:00905110.7G6PD, PGD
4defense response to protozoanGO:04283210.7SLC11A1, IL4, IFNG
5negative regulation of chronic inflammatory responseGO:00267710.6FOXP3, IL4
6regulation of proton transportGO:01015510.6IL4, IL13
7positive regulation of isotype switching to IgG isotypesGO:04830410.6IFNG, IL4
8positive regulation of T cell proliferationGO:04210210.6IFNG, IL4, PNP
9positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.6LTA, FCER2
10positive regulation of immunoglobulin productionGO:00263910.5IL13, FOXP3
11positive regulation of MHC class II biosynthetic processGO:04534810.5IL4, IFNG
12positive regulation of chemokine biosynthetic processGO:04508010.5IL4, IFNG
13negative regulation of growth of symbiont in hostGO:04413010.4LTA, IFNG
14response to ethanolGO:04547110.4G6PD, IL13, IL4
15pentose-phosphate shuntGO:00609810.3PGD, G6PD
16response to drugGO:04249310.0PNP, IL4, LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.3IL4, IL13, LTA, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Leishmaniasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet