MCID: CTN007
MIFTS: 56

Cutaneous Leishmaniasis malady

Infectious diseases category
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Summaries for Cutaneous Leishmaniasis

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Disease Ontology:8 A leishmaniasis that involves skin infection caused by leishmania species, resulting in one or more cutaneous lesions.

MalaCards based summary: Cutaneous Leishmaniasis, also known as asian desert cutaneous leishmaniasis, is related to leishmaniasis and leprosy. An important gene associated with Cutaneous Leishmaniasis is MPI (mannose phosphate isomerase), and among its related pathways are IL4-mediated signaling events and Glucocorticoid receptor regulatory network. The drug meglumine and the compounds fe2+ and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related mouse phenotypes are digestive/alimentary and immune system.

Wikipedia:65 Cutaneous leishmaniasis () is the most common form of leishmaniasis. It is a skin infection caused by a... more...

Aliases & Classifications for Cutaneous Leishmaniasis

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Cutaneous Leishmaniasis, Aliases & Descriptions:

Name: Cutaneous Leishmaniasis 30 8 10
Asian Desert Cutaneous Leishmaniasis 8 62
Diffuse Cutaneous Leishmaniasis 8 62
Ethiopian Cutaneous Leishmaniasis 62
 
Leishmaniasis Diffuse Cutaneous 44
Leishmaniasis, Cutaneous 62
Leishmaniasis Cutaneous 44
Leproid Leishmaniasis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:9111
NCIt39 C34768
SNOMED-CT57 240637006
MeSH34 D016773
ICD1025 B55.1

Related Diseases for Cutaneous Leishmaniasis

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Diseases related to Cutaneous Leishmaniasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis31.2SLC11A1, IL13, IFNG, MT-CYB, PGD, MPI
2leprosy31.2SLC11A1
3dermatitis30.5IL13, IFNG
4pulmonary tuberculosis30.4SLC11A1, IFNG
5lepromatous leprosy30.3IFNG, LTA
6pulmonary sarcoidosis30.2LTA, IFNG
7visceral leishmaniasis30.2PGD, IFNG, SLC11A1, LTA
8sarcoidosis29.5FCER2, IFNG, IL13, SLC11A1, LTA
9arthritis29.5FCER2, IFNG, IL13, SLC11A1, LTA
10mucocutaneous leishmaniasis10.5
11erysipeloid10.5
12blindness10.4
13paronychia10.3
14granulomatous dermatitis10.3
15iron metabolism disease10.2MT-CYB, SLC11A1
16ankylosing spondylitis10.2
17acquired immunodeficiency syndrome10.2
18panniculitis10.2
19spondylitis10.2
20lipoid nephrosis10.2FCER2, IL13
21allergic rhinitis10.2FCER2, IL13
22pneumonia10.2IL13, MT-CYB
23aspergillosis10.2IFNG, MT-CYB
24bronchiolitis10.2IL13, FCER2
25chronic granulomatous disease10.2MT-CYB, IFNG
26juvenile rheumatoid arthritis10.1SLC11A1, LTA
27bullous pemphigoid10.1FCER2, IL13
28rhinitis10.1IL13, FCER2
29acute graft versus host disease10.1LTA, IFNG
30toxic shock syndrome10.1LTA, IFNG
31schistosomiasis10.1IL13, IFNG
32chromoblastomycosis10.1
33tuberculoid leprosy10.1
34lobomycosis10.1
35follicular mucinosis10.1
36african tick-bite fever10.1
37psoriatic arthritis10.1
38herpes zoster10.1
39necrobiosis lipoidica10.1
40basal cell carcinoma10.1
41blepharitis10.1
42blepharoconjunctivitis10.1
43cellulitis10.1
44ectropion10.1
45elephantiasis10.1
46lagophthalmos10.1
47lupus erythematosus10.1
48lymphopenia10.1
49pericarditis10.1
50trypanosomiasis10.1

Graphical network of the top 20 diseases related to Cutaneous Leishmaniasis:



Diseases related to cutaneous leishmaniasis

Symptoms for Cutaneous Leishmaniasis

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Drugs & Therapeutics for Cutaneous Leishmaniasis

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Drug clinical trials:

Search ClinicalTrials for Cutaneous Leishmaniasis

Search NIH Clinical Center for Cutaneous Leishmaniasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cutaneous Leishmaniasis

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Anatomical Context for Cutaneous Leishmaniasis

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MalaCards organs/tissues related to Cutaneous Leishmaniasis:

32
Skin, T cells, Monocytes, Testes, Whole blood, Lymph node, Colon, Kidney, Liver, Pancreas, Salivary gland, Nk cells

Animal Models for Cutaneous Leishmaniasis or affiliated genes

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MGI Mouse Phenotypes related to Cutaneous Leishmaniasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4FCER2, IFNG, IL13, SLC11A1
2MP:00053878.1LTA, SLC11A1, IL13, IFNG, FCER2
3MP:00053977.7LTA, SLC11A1, IL13, IFNG, FCER2, MPI
4MP:00107687.6MPI, FCER2, IFNG, IL13, SLC11A1, LTA

Publications for Cutaneous Leishmaniasis

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Articles related to Cutaneous Leishmaniasis:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Zosteriform cutaneous leishmaniasis. (25396096)
2014
2
Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof-of-concept for a novel self-administered therapeutic modality. (25363817)
2014
3
Cutaneous Leishmaniasis Mimicking A Pyogenic Granuloma. (24923493)
2014
4
Rare variants of cutaneous leishmaniasis presenting as eczematous lesions. (25405136)
2014
5
Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. (22750767)
2013
6
Pentalinon andrieuxii Root Extract is Effective in the Topical Treatment of Cutaneous Leishmaniasis Caused by Leishmania mexicana. (24347110)
2013
7
Clinical findings and management of imported cutaneous leishmaniasis: report of 14 cases from Austria. (23522841)
2013
8
LeishmaniaA braziliensis-Reactive T Cells Are Down-Regulated in Long-Term Cured Cutaneous Leishmaniasis, but the Renewal Capacity of T Effector Memory Compartments Is Preserved. (24303052)
2013
9
Leishmanicidal activity of amphotericin B encapsulated in PLGA-DMSA nanoparticles to treat cutaneous leishmaniasis in C57BL/6 mice. (23891944)
2013
10
Cluster of zoonotic cutaneous leishmaniasis (Leishmania major) in European travelers returning from Turkmenistan. (24165385)
2013
11
Cutaneous leishmaniasis with unusual clinical and histological presentation: report of four cases. (23690110)
2013
12
Molecular characterization of leishmania infection from naturally infected sand flies caught in a focus of cutaneous leishmaniasis (eastern iran). (24409437)
2013
13
Simultaneous infection with Leishmania (Viannia) braziliensis and L. (V.) lainsoni in a Peruvian patient with cutaneous leishmaniasis. (23382155)
2013
14
Intralesional antimony for single lesions of bolivian cutaneous leishmaniasis. (23390069)
2013
15
Travelers with cutaneous leishmaniasis cured without systemic therapy. (23633111)
2013
16
Sandflies (Diptera: Psychodidae) in rural and urban environments in an endemic area of cutaneous leishmaniasis in southern Brazil. (23778669)
2013
17
Cutaneous leishmaniasis in Al Hassa, Saudi Arabia: epidemiological trends from 2000 to 2010. (23790342)
2013
18
Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis. (22882996)
2012
19
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis. (22823491)
2012
20
The knowledge, attitude, and prevention practices of students regarding cutaneous leishmaniasis in the hyperendemic region of the Shahid Babaie Airbase. (22022818)
2012
21
Cutaneous leishmaniasis acquired in Jura, France. (22257720)
2012
22
Correlation of clinical, parasitological and histopathological diagnosis of cutaneous leishmaniasis in an endemic region in Sri Lanka. (23292056)
2012
23
Latency time in cutaneous leishmaniasis. (21505401)
2011
24
PKCI' regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. (21287553)
2011
25
First report on natural infection of Phlebotomus sergenti with Leishmania promastigotes in the cutaneous leishmaniasis focus in southeastern Tunisia. (21976566)
2011
26
Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis. (21747837)
2011
27
Lupoid cutaneous leishmaniasis: a case report. (22984663)
2011
28
An outbreak of suspected cutaneous leishmaniasis in Ghana: lessons learnt and preparation for future outbreaks. (21765823)
2011
29
Sand fly Surveillance within an Emerging Epidemic Focus of Cutaneous Leishmaniasis in Southeastern Iran. (22808384)
2010
30
Treatment of acute cutaneous leishmaniasis with intralesional injection of meglumine antimoniate: comparison of conventional technique with mesotherapy gun. (20883265)
2010
31
CD8+ T cells as a source of IFN-I^ production in human cutaneous leishmaniasis. (20967288)
2010
32
Comparison of three methods for diagnosis of cutaneous leishmaniasis. (22347259)
2010
33
Study of sand fly fauna in an endemic area of American cutaneous leishmaniasis and canine visceral leishmaniasis in the municipality of EspA-rito Santo do Pinhal, SALo Paulo, Brazil. (20428683)
2010
34
Cutaneous leishmaniasis of the lid: a report of nine cases. (20157413)
2010
35
Eight cases of feline cutaneous leishmaniasis in Texas. (20826847)
2010
36
Evaluation of intralesional 0.2% ciprofloxacin as a treatment for cutaneous leishmaniasis. (20214164)
2010
37
The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. (20493664)
2010
38
Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. (20854864)
2010
39
Molecular characterization of Leishmania species isolated from cutaneous leishmaniasis in Yemen. (20862227)
2010
40
Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. (19566354)
2009
41
IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. (19201909)
2009
42
Relapsing cutaneous leishmaniasis in a patient with ankylosing spondylitis treated with infliximab. (19556566)
2009
43
Evaluation of meglumine antimoniate effects on liver, kidney and pancreas function tests in patients with cutaneous leishmaniasis. (17951131)
2007
44
Ocular involvement in cutaneous leishmaniasis four cases with blepharoconjunctivitis. (15117121)
2004
45
Rhabdomyolysis induced by pentamidine (Pentacarinat) during treatment of cutaneous leishmaniasis: 2 cases]. (11937930)
2002
46
The efficacy of pentamidine combined with allopurinol and immunotherapy for the treatment of patients with diffuse cutaneous leishmaniasis. (9951957)
1999
47
In situ expression of interleukin-10 and interleukin-12 in active human cutaneous leishmaniasis. (8880134)
1996
48
Anergic cutaneous leishmaniasis versus lobomycosis. (8737881)
1996
49
CD23 and IgE expression during the human immune response to cutaneous leishmaniasis: possible role in monocyte activation. (8008965)
1994
50
Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. (8132347)
1994

Variations for Cutaneous Leishmaniasis

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Expression for genes affiliated with Cutaneous Leishmaniasis

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Expression patterns in normal tissues for genes affiliated with Cutaneous Leishmaniasis

Search GEO for disease gene expression data for Cutaneous Leishmaniasis.

Pathways for genes affiliated with Cutaneous Leishmaniasis

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Pathways related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FCER2, LTA
29.4IL13, IFNG
39.4IFNG, IL13
49.4IL13, IFNG
5
Show member pathways
9.3IFNG, LTA
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3IFNG, LTA
7
Show member pathways
IL27-mediated signaling events37
9.3IFNG, LTA
88.8IL13, IFNG, LTA
9
Show member pathways
8.8LTA, IFNG, IL13
108.8IFNG, IL13, LTA
11
Show member pathways
8.8IFNG, IL13, LTA
12
Show member pathways
8.4FCER2, IFNG, IL13, LTA

Compounds for genes affiliated with Cutaneous Leishmaniasis

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Compounds related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1fe2+449.9SLC11A1, MT-CYB
2alpha-galactosylceramide449.8IL13, IFNG
3glatiramer acetate44 1110.8IL13, IFNG
4pirfenidone44 6110.8IFNG, IL13
5amphotericin b449.8IFNG, IL13
6il-12449.8IFNG, IL13
7indoleamine449.8IL13, IFNG
8nickel44 2410.7IL13, SLC11A1
96-phosphogluconate449.7PGD, MPI
10gm-csf44 2810.6IFNG, IL13
11fumarate44 1110.6IFNG, MT-CYB, MPI
12budesonide44 50 1111.6IFNG, IL13
13cellulose acetate449.6MPI, PGD
14isocitrate449.5PGD, MPI
15nadp+449.5MT-CYB, PGD
16salbutamol44 50 28 24 1113.4IL13, FCER2
17allergens449.4IL13, FCER2, IFNG
18hydrocortisone44 2 61 1112.4IL13, FCER2, IFNG
19okt3449.4FCER2, IFNG, LTA
20neopterin449.3IFNG, LTA, FCER2
21herbimycin a44 6110.3IFNG, FCER2, LTA
22sb 20358044 6110.3IL13, FCER2, IFNG
23glyceraldehyde 3-phosphate449.2PGD, MPI, MT-CYB
24il 10449.2IL13, IFNG, LTA
25pentoxifylline44 1110.2IL13, LTA, IFNG
26prednisolone44 28 1111.2LTA, IFNG, IL13
27endotoxin449.2IFNG, LTA, IL13
28rantes449.1IFNG, LTA, IL13
29fluticasone propionate44 50 61 1112.1IL13, IFNG
30indomethacin44 28 61 1112.1IL13, LTA, IFNG
31histamine44 28 2411.0IFNG, IL13, FCER2
32thymidine44 2410.0IL13, IFNG, FCER2, MT-CYB
33fmlp448.9IL13, LTA, MT-CYB, FCER2
34superoxide44 249.9MT-CYB, PGD, MPI, FCER2
35ionomycin448.8LTA, IL13, IFNG, FCER2
36calcitriol44 61 24 1111.8IL13, FCER2, IFNG, LTA
37pge2448.8LTA, FCER2, IFNG, IL13
38threonine448.8MT-CYB, LTA, FCER2, IL13
39dexamethasone44 50 28 1111.8LTA, IFNG, IL13, FCER2
40mannose448.7LTA, SLC11A1, IL13, FCER2, MPI
41lactate448.5FCER2, IL13, PGD, LTA
42retinoic acid44 249.5LTA, IL13, IFNG, FCER2
43aspartate448.5IL13, MPI, SLC11A1, PGD, MT-CYB
44oxygen44 249.5SLC11A1, MT-CYB, PGD, LTA
45serine448.4IL13, MT-CYB, LTA, FCER2, FCN2
46h2o2448.4LTA, IL13, MT-CYB, PGD
47cycloheximide448.4IL13, FCER2, IFNG, LTA, MT-CYB
48glutamate448.4LTA, IL13, MT-CYB, PGD
49glucose448.3PGD, LTA, MT-CYB, MPI
50nitric oxide44 24 119.2IFNG, LTA, SLC11A1, IL13, MT-CYB, PGD

GO Terms for genes affiliated with Cutaneous Leishmaniasis

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Cellular components related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IFNG, FCER2

Biological processes related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of killing of cells of other organismGO:0517129.7FCER2, IFNG
2defense response to protozoanGO:0428329.7SLC11A1, IFNG
3positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6LTA, FCER2
4protein import into nucleus, translocationGO:0000609.6IFNG, SLC11A1
5negative regulation of growth of symbiont in hostGO:0441309.4IFNG, LTA
6cellular component movementGO:0069289.4IL13, IFNG
7positive regulation of interferon-gamma productionGO:0327299.4SLC11A1, LTA
8response to lipopolysaccharideGO:0324969.1IL13, SLC11A1, LTA
9humoral immune responseGO:0069599.0LTA, IFNG

Molecular functions related to Cutaneous Leishmaniasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.8LTA, IL13, IFNG

Products for genes affiliated with Cutaneous Leishmaniasis

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Sources for Cutaneous Leishmaniasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet