MCID: CTN003
MIFTS: 51

Cutaneous Lupus Erythematosus malady

Rare diseases, Skin diseases, Immune diseases categories

Summaries for Cutaneous Lupus Erythematosus

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight.

MalaCards: Cutaneous Lupus Erythematosus, also known as lupus erythematosus, cutaneous, is related to lupus erythematosus and systemic lupus erythematosus, and has symptoms including warts/papillomas, skin photosensitivity and telangiectasiae of the skin. An important gene associated with Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Apoptosis and RNA Polymerase I Promoter Opening. The compounds 5-aza-2deoxycytidine and cytosine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Cutaneous Lupus Erythematosus

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 46Novoseek, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet, 37MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases
Orphanet: 50 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

50
cutaneous lupus erythematosus:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cutaneous lupus erythematosus 9 44 11 50
lupus erythematosus, cutaneous 44 63
lupus erythematosus cutaneous 46


External Ids:

Disease Ontology9 DOID:0050169
SNOMED-CT via Orphanet60 7119001
UMLS via Orphanet64 C0024137
ICD10 via Orphanet27 L93.0, L93.1, L93.2
MESH via Orphanet37 D008178

Related Diseases for Cutaneous Lupus Erythematosus

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cutaneous Lupus Erythematosus:



Diseases related to cutaneous lupus erythematosus

Symptoms for Cutaneous Lupus Erythematosus

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50Orphanet
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Symptoms:

50 (show all 21)
  • warts/papillomas
  • skin photosensitivity
  • telangiectasiae of the skin
  • irregular/in bands/reticular skin hyperpigmentation
  • cutaneous inflammation
  • cutaneous edema
  • pruritus/itching
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • freezing lesions
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • psoriasis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • dermal/subcutaneous infiltration/induration

Drugs & Therapeutics for Cutaneous Lupus Erythematosus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Cutaneous Lupus Erythematosus

Search CenterWatch for Cutaneous Lupus Erythematosus

Genetic Tests for Cutaneous Lupus Erythematosus

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Anatomical Context for Cutaneous Lupus Erythematosus

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34MalaCards
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MalaCards organs/tissues related to Cutaneous Lupus Erythematosus:

34
Skin, T cells, Breast, Testes, Lung, Prostate, Brain, Thymus, B cells

Animal Models for Cutaneous Lupus Erythematosus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cutaneous Lupus Erythematosus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MBD4, MBD3, PRF1
2MP:00053877.8TRIM21, MBD3, PRF1, IRF5, C1QA
3MP:00053847.7C1QA, PRF1, MBD3, MBD1, MBD4
4MP:00053767.5IRF5, PRF1, MBD3, MBD4, TRIM21
5MP:00107687.4C1QA, PRF1, MBD3, MBD4, TRIM21

Publications for Cutaneous Lupus Erythematosus

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53PubMed
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Articles related to Cutaneous Lupus Erythematosus:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Characterization of clinical photosensitivity in cutaneous lupus erythematosus. (23648190)
2013
2
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
3
Cutaneous lupus erythematosus: clinical aspects and molecular pathogenesis. (23464352)
2013
4
TNF blockade and cutaneous lupus erythematosus: where do we stand and where are we going? (23902545)
2013
5
Cutaneous lupus erythematosus: diagnosis and treatment. (24238695)
2013
6
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
7
A case of subacute cutaneous lupus erythematosus as a result of ranibizumab (Lucentis) treatment. (24212210)
2013
8
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
9
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
10
Effectiveness of topical calcineurin inhibitors as monotherapy or in combination with hydroxychloroquine in cutaneous lupus erythematosus. (21707772)
2012
11
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
12
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
13
Linear cutaneous lupus erythematosus on the midline of the face. (21352282)
2011
14
Familial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLE. (21132284)
2011
15
Quality of life in cutaneous lupus erythematosus. (21397983)
2011
16
Cutaneous lupus erythematosus: update of therapeutic options part II. (20800319)
2011
17
Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates. (20693199)
2010
18
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
19
The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosus. (20693209)
2010
20
Prominent Degos-like skin lesions in a patient with chronic cutaneous lupus erythematosus. (20673533)
2010
21
Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus. (19712116)
2010
22
Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. (19515045)
2009
23
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
24
Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus. (19162247)
2009
25
Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus. (18811868)
2008
26
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
27
Identification of type I interferon-associated inflammation in the pathogenesis of cutaneous lupus erythematosus opens up options for novel therapeutic approaches. (17437489)
2007
28
Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototesting. (17100736)
2006
29
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
30
Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. (15880822)
2005
31
Ro/SSA-positive cutaneous lupus erythematosus induced by carbamazepine. (15655159)
2005
32
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
33
Thalidomide treatment for hypertrophic cutaneous lupus erythematosus. (15764048)
2004
34
Eleven cases of vesicular cutaneous lupus erythematosus in Shetland sheepdogs and rough collies: clinical management and prognosis. (14989704)
2004
35
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
36
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
37
Current treatment of cutaneous lupus erythematosus. (11328623)
2001
38
Erythema multiforme-like subacute cutaneous lupus erythematosus: a new variety? (11028873)
2000
39
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
40
High-dose intravenous immunoglobulin in cutaneous lupus erythematosus. (10490126)
1999
41
Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus. (9665402)
1998
42
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
43
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
44
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
45
Guidelines of care for cutaneous lupus erythematosus. American Academy of Dermatology. (8632082)
1996
46
Histological detection of c-myb and c-myc proto-oncogene expression in infiltrating cells in cutaneous lupus erythematosus-like lesions of MRL/l mice by in situ hybridization. (1728975)
1992
47
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
48
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
49
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
50
Subacute cutaneous lupus erythematosus presenting as erythroderma. (2970478)
1988

Variations for Cutaneous Lupus Erythematosus

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Expression for genes affiliated with Cutaneous Lupus Erythematosus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Cutaneous Lupus Erythematosus

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Cutaneous Lupus Erythematosus

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46Novoseek, 25HMDB
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Compounds related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine469.5MBD4, MBD1
2cytosine46 2510.2MBD4, MBD1

GO Terms for genes affiliated with Cutaneous Lupus Erythematosus

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17Gene Ontology
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Biological processes related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.2PRF1, IRF5

Molecular functions related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:0083279.3MBD1, MBD3
2protein bindingGO:0055156.4TRIM21, MBD4, MBD1, MBD3, PRF1, IRF5

Products for genes affiliated with Cutaneous Lupus Erythematosus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Lupus Erythematosus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet