MCID: CTN003
MIFTS: 53

Cutaneous Lupus Erythematosus malady

Skin category

Summaries for Cutaneous Lupus Erythematosus

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight.

MalaCards: Cutaneous Lupus Erythematosus, also known as lupus erythematosus, cutaneous, is related to systemic lupus erythematosus and arthritis, and has symptoms including dermal/subcutaneous infiltration/induration, articular/joint pain/arthralgia and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Cytokine Network. The compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cutaneous Lupus Erythematosus

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
cutaneous lupus erythematosus:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cutaneous lupus erythematosus 8 43 10 49
lupus erythematosus, cutaneous 43 61
lupus erythematosus cutaneous 45


External Ids:

Disease Ontology8 DOID:0050169
ICD10 via Orphanet26 L93
SNOMED-CT via Orphanet58 7119001
UMLS via Orphanet62 C0024137
MESH via Orphanet36 D008178

Related Diseases for Cutaneous Lupus Erythematosus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cutaneous Lupus Erythematosus family:

subacute cutaneous lupus erythematosus

Diseases related to Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.3CCR4, IFNA1, TNF, APOH, TROVE2, TRIM21
2arthritis30.7TNF
3vasculitis30.6IFNA2, TNF, APOH, TRIM21
4urticaria30.4ACE
5lichen planus30.4IFNA2
6mycosis fungoides30.4CCR4, CCL17, CCL27, IFNA2, IFNA1
7crohn's disease30.2TNF
8polymyositis30.2RNPC3
9mixed connective tissue disease30.2APOH, RNPC3
10systemic scleroderma30.2ACE
11hepatitis c30.2IRF7, TNF, IFNA1, IFNA2
12sjogren's syndrome30.2CCL27, APOH, TROVE2, TRIM21, RNPC3
13subacute cutaneous lupus erythematosus11.4
14drug-induced lupus erythematosus10.8
15discoid lupus erythematosus10.7
16toxic epidermal necrolysis10.6
17porphyria cutanea tarda10.4
18cutaneous porphyria10.4
19lupus erythematosus tumidus10.4
20chilblain lupus10.4
21lupus erythematosus panniculitis10.4
22erythema multiforme10.3
23alopecia10.3
24squamous cell carcinoma10.3
25tinea corporis10.3
26kikuchi disease10.3
27squamous cell papilloma10.1
28acute pancreatitis10.1
29antiphospholipid syndrome10.1
30aggressive periodontitis10.1
31molluscum contagiosum10.1
32rosacea10.1
33hereditary angioedema10.1
34epidermolysis bullosa acquisita10.1
35keratoconjunctivitis sicca10.1
36hepatitis e10.1
37inclusion body myositis10.1
38skin meningioma10.1
39pemphigus10.1
40pityriasis rubra pilaris10.1
41microphthalmia10.1
42localized scleroderma10.1
43sialadenitis10.1
44herpes zoster10.1
45n syndrome10.1
46vitiligo10.1
47hepatitis a10.1
48acute myocardial infarction10.1
49adenocarcinoma10.1
50alopecia areata10.1

Graphical network of the top 20 diseases related to Cutaneous Lupus Erythematosus:



Diseases related to cutaneous lupus erythematosus

Clinical Features for Cutaneous Lupus Erythematosus

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 21)
  • dermal/subcutaneous infiltration/induration
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • freezing lesions
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • psoriasis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • cutaneous edema
  • cutaneous inflammation
  • irregular/in bands/reticular skin hyperpigmentation
  • telangiectasiae of the skin
  • skin photosensitivity
  • warts/papillomas

Drugs & Therapeutics for Cutaneous Lupus Erythematosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cutaneous Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Cutaneous Lupus Erythematosus

Search CenterWatch for Cutaneous Lupus Erythematosus

Genetic Tests for Cutaneous Lupus Erythematosus

Anatomical Context for Cutaneous Lupus Erythematosus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cutaneous Lupus Erythematosus:

33
Skin, Brain, Lung, Thymus, Heart, Breast, Prostate, T cells, B cells, Endothelial

Animal Models for Cutaneous Lupus Erythematosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cutaneous Lupus Erythematosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6MBD3, MBD4, MBD1, TNF, PRF1, TROVE2
2MP:00053879.2ACE, C1QA, CCR4, CCL17, MBD3, TNF

Publications for Cutaneous Lupus Erythematosus

Sources:
51PubMed
See all sources

Articles related to Cutaneous Lupus Erythematosus:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
A case of subacute cutaneous lupus erythematosus in a patient with mixed connective tissue disease: successful treatment with plasmapheresis and rituximab. (23984162)
2013
2
Response to hydroxychloroquine in Japanese patients with lupus-related skin disease using the cutaneous lupus erythematosus disease area and severity index (CLASI). (22581095)
2013
3
Cutaneous hypertrophic lupus erythematosus: a challenging histopathologic diagnosis in the absence of clinical information. (23991731)
2013
4
Taxane associated subacute cutaneous lupus erythematosus. (24021438)
2013
5
A case of vesicular cutaneous lupus erythematosus in a Border collie successfully treated with topical tacrolimus and nicotinamide-tetracycline. (24118370)
2013
6
Terbinafine-induced subacute cutaneous lupus erythematosus in two patients with systemic lupus erythematosus successfully treated with topical corticosteroids. (24278085)
2013
7
Capecitabine-induced subacute cutaneous lupus erythematosus: Report of a case with positive rechallenge test. (24111883)
2013
8
Effectiveness of topical calcineurin inhibitors as monotherapy or in combination with hydroxychloroquine in cutaneous lupus erythematosus. (21707772)
2012
9
Cutaneous phaeohyphomycosis caused by Exophiala spinifera in a patient with systemic lupus erythematosus. (22065094)
2012
10
Koebner phenomenon to heat in cutaneous (discoid) lupus erythematosus (lupus ab-igne). (23286807)
2012
11
Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNI>) in cutaneous lupus erythematosus. (20720564)
2011
12
Cutaneous lupus erythematosus: update of therapeutic options part I. (20739095)
2011
13
Enhanced CCR5+/CCR3+ T helper cell ratio in patients with active cutaneous lupus erythematosus. (21844117)
2011
14
Manifestations and treatment of cutaneous lupus erythematosus (Part II of II). (22134575)
2011
15
Cutaneous lupus erythematosus induced by adalimumab. (21342233)
2011
16
Linear cutaneous lupus erythematosus. (22016286)
2011
17
The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosus. (20693209)
2010
18
A revised scoring system for cutaneous lupus erythematosus: the RCLASI. (20645979)
2010
19
Periorbital mucinosis: a variant of cutaneous lupus erythematosus? (20153078)
2010
20
Drug-induced subacute cutaneous lupus erythematosus. (20693204)
2010
21
Anti-Ro andA anti-La antibody positive subacute cutaneous lupus erythematosus (SCLE) induced byA lansoprazole. (20974555)
2010
22
Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region. (20305048)
2010
23
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
24
Incidence of cutaneous lupus erythematosus, 1965-2005: a population-based study. (19289752)
2009
25
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
26
High frequency of vitamin D deficiency among patients with cutaneous lupus erythematosus [corrected]. (18503598)
2008
27
Incidental cases of subacute cutaneous lupus erythematosus in association with malignancy. (18955207)
2008
28
Neutrophilic cutaneous lupus erythematosus. At the edge between innate and acquired immunity? (18230975)
2008
29
Limited cutaneous systemic sclerosis associated with discoid lupus erythematosus in two Japanese patients with anticentromere antibodies. (17927793)
2007
30
Pathophysiology of cutaneous lupus erythematosus--novel aspects. (16987823)
2006
31
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
32
Bupropion-induced subacute cutaneous lupus erythematosus. (16197429)
2005
33
Subacute cutaneous lupus erythematosus precipitated by leflunomide. (16197407)
2005
34
Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus. (15955100)
2005
35
Docetaxel (taxotere) induced subacute cutaneous lupus erythematosus: report of 4 cases. (15088316)
2004
36
Erythema elevatum diutinum associated with lupus panniculitis in a patient with discoid lesions of chronic cutaneous lupus erythematosus. (15034527)
2004
37
Photosensitivity in cutaneous lupus erythematosus: lessons from mice and men. (14581133)
2003
38
Subacute cutaneous lupus erythematosus presenting in a child. (11869212)
2002
39
Ulcerative dermatosis of the Shetland sheepdog and rough collie dog may represent a novel vesicular variant of cutaneous lupus erythematosus. (11301535)
2001
40
Long-term cefuroxime axetil in subacute cutaneous lupus erythematosus. A report of three cases. (10773701)
2000
41
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
42
Cutaneous Mycobacterium kansasii infection in a patient with systemic lupus erythematosus: case report and review. (10025869)
1999
43
Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus. (9665402)
1998
44
Dapsone syndrome in cutaneous lupus erythematosus. (8730143)
1996
45
Subacute cutaneous lupus erythematosus. (20952973)
1995
46
Subacute cutaneous lupus erythematosus-like gyrate erythema and hypertrichosis lanuginosa acquisita associated with uterine adenocarcinoma. (1419767)
1992
47
Subacute cutaneous lupus erythematosus during PUVA therapy for psoriasis: case report and review of the literature. (2649111)
1989
48
Hereditary angioedema associated with subacute cutaneous lupus erythematosus. (2620753)
1989
49
Subacute cutaneous lupus-erythematosus in childhood. (2612123)
1989
50
Subacute cutaneous lupus erythematosus. Clinical, serologic, immunogenetic, and therapeutic considerations in seventy-two patients. (3261587)
1988

Genetic Variations for Cutaneous Lupus Erythematosus

Expression for genes affiliated with Cutaneous Lupus Erythematosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Cutaneous Lupus Erythematosus

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG, 53R&D Systems, 38NCBI BioSystems Database
See all sources

Pathways related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
10.3IRF7, IFNA2
210.2TNF, IFNA1, IFNA2
3
Hide members
10.2IFNA2, IFNA1, IRF7
410.1CCR4, CCL17, CCL27
5
Hide members
10.1C1QA, TNF, TROVE2, TRIM21
6
Hide members
10.1IFNA2, IFNA1, TNF, PRF1
7
Hide members
10.1PRF1, TNF, IFNA1, IFNA2
810.1EEA1, TNF, IFNA1, IFNA2
9
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10.1TRIM21, IRF7, IFNA1, IFNA2
1010.1IFNA2, IFNA1, TNF, IRF7
11
Hide members
10.1IFNA2, IFNA1, TNF, IRF7
12
Hide members
10.1IRF7, TNF, IFNA1, IFNA2
13
Hide members
10.1IRF7, TNF, IFNA1, IFNA2
14
Hide members
10.0CCR4, CCL17, CCL27, IFNA1
15
Hide members
10.0TNF, IFNA1, IFNA2, CCL27, CCL17
16
Hide members
9.9ACE, IRF7, TNF, IFNA1, IFNA2, C1QA

Compounds for genes affiliated with Cutaneous Lupus Erythematosus

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1pegasys4510.7IFNA1, IFNA2
2entecavir4510.7IFNA2, IFNA1
3mizoribine4510.6IFNA2, IFNA1
4famciclovir45 1111.6IFNA2, IFNA1
5intron a4510.6IFNA2, IFNA1
6n-phosphonacetyl-l-aspartate4510.6IFNA2, IFNA1
7hydroxychloroquine45 1111.6IFNA2, TNF, APOH
8rantes4510.6IRF7, TNF, IFNA1
9imiquimod45 29 60 1113.6TNF, IFNA1, IFNA2
10infliximab45 50 1112.6IFNA2, TNF, APOH
11polyinosinic-polycytidylic acid4510.5IRF7, TNF, IFNA1
12etanercept45 50 1112.5C1QA, IFNA2, TNF, APOH
13poly(i-c)4510.5IRF7, TNF, IFNA1
14anagrelide45 1111.5IFNA2, IFNA1
15pentostatin45 60 29 1113.5IFNA2, IFNA1
16lomustine45 1111.5IFNA2, IFNA1
172,5-oligoadenylate4510.5IRF7, TNF, IFNA1, IFNA2
185-deoxy-5-fluorouridine4510.5IFNA1, IFNA2
19ifn-alpha4510.5IRF7, IFNA1, IFNA2
20melphalan45 1111.5IFNA2, IFNA1, TNF
21atpo45 2911.5APOH, IFNA1
22neopterin4510.5TNF, IFNA1, IFNA2
23rituximab45 50 1112.4C1QA, IFNA2, IFNA1, TNF, APOH
24ccl445 2911.4CCR4, CCL17, CCL27
25tarc4510.4TNF, CCL27, CCL17, CCR4
26prednisolone45 29 1112.4CCR4, IFNA2, IFNA1, TNF, APOH
27ccl345 2911.4CCR4, CCL17, CCL27, IFNA1, TNF
28superoxide45 2411.4IFNA2, TNF, APOH, PRF1, KRT15
29adefovir4510.3IFNA2, IFNA1
30thalidomide45 50 60 1113.3IFNA2, IFNA1, TNF
31alefacept45 1111.3TNF, C1QA
32chloroquine45 2 50 29 1114.3EEA1, TNF, IFNA1
33amantadine45 1111.3IFNA1, IFNA2
34efalizumab45 1111.2TNF, C1QA
35lipid4510.1CCR4, CCL27, IFNA2, TNF, APOH, ACE
36zinc45 2411.0EEA1, CCR4, IFNA2, MBD4, APOH, TROVE2
37cholesterol45 29 11 2412.7CCL27, APOH, PRF1, ACE, EEA1

GO Terms for genes affiliated with Cutaneous Lupus Erythematosus

Sources:
16Gene Ontology
See all sources

Cellular components related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8CCL17, CCL27, IFNA2, TNF, PRF1, IL17F
2extracellular spaceGO:0056159.5ACE, CCL17, CCL27, IFNA2, TNF, APOH

Biological processes related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:03247910.3TRIM21, IRF7
2inflammatory responseGO:0069549.9IL17F, TNF, IFNA2, CCL17, CCR4
3cell-cell signalingGO:0072679.8C1QA, CCL17, CCL27, IFNA2

Molecular functions related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.4EEA1, IFNA2, MBD3, MBD4, MBD1, TNF

Products for genes affiliated with Cutaneous Lupus Erythematosus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Lupus Erythematosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet