MCID: CTN003
MIFTS: 41

Cutaneous Lupus Erythematosus malady

Rare diseases, Skin diseases categories

Summaries for Cutaneous Lupus Erythematosus

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Disease Ontology:9 A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight.

MalaCards based summary: Cutaneous Lupus Erythematosus, also known as lupus erythematosus, cutaneous, is related to lupus erythematosus and systemic lupus erythematosus, and has symptoms including dry skin, hyperkeratosis and edema. An important gene associated with Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Apoptosis and RNA Polymerase I Promoter Opening. The compounds 5-aza-2deoxycytidine and cytosine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Cutaneous Lupus Erythematosus

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Cutaneous Lupus Erythematosus, Aliases & Descriptions:

Name: Cutaneous Lupus Erythematosus 9 41 11
Lupus Erythematosus, Cutaneous 41 60
 
Lupus Erythematosus Cutaneous 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:0050169

Related Diseases for Cutaneous Lupus Erythematosus

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Graphical network of the top 20 diseases related to Cutaneous Lupus Erythematosus:



Diseases related to cutaneous lupus erythematosus

Symptoms for Cutaneous Lupus Erythematosus

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HPO human phenotypes related to Cutaneous Lupus Erythematosus:

(show all 14)
id Description Frequency HPO Source Accession
1 dry skin hallmark (90%) HP:0000958
2 hyperkeratosis hallmark (90%) HP:0000962
3 edema hallmark (90%) HP:0000969
4 skin rash hallmark (90%) HP:0000988
5 pruritus hallmark (90%) HP:0000989
6 hypermelanotic macule hallmark (90%) HP:0001034
7 acrocyanosis hallmark (90%) HP:0001063
8 arthralgia hallmark (90%) HP:0002829
9 psoriasis hallmark (90%) HP:0003765
10 abnormal blistering of the skin hallmark (90%) HP:0008066
11 teleangiectasia of the skin hallmark (90%) HP:0100585
12 skin ulcer hallmark (90%) HP:0200042
13 cutaneous photosensitivity occasional (7.5%) HP:0000992
14 verrucae occasional (7.5%) HP:0200043

Drugs & Therapeutics for Cutaneous Lupus Erythematosus

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Drug clinical trials:

Search ClinicalTrials for Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Cutaneous Lupus Erythematosus

Genetic Tests for Cutaneous Lupus Erythematosus

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Anatomical Context for Cutaneous Lupus Erythematosus

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MalaCards organs/tissues related to Cutaneous Lupus Erythematosus:

31
Skin, T cells, Breast, Lung, Testes, Neutrophil, Thymus, Brain, Prostate, B cells

Animal Models for Cutaneous Lupus Erythematosus or affiliated genes

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MGI Mouse Phenotypes related to Cutaneous Lupus Erythematosus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MBD4, MBD3, PRF1
2MP:00053877.8TRIM21, MBD3, PRF1, IRF5, C1QA
3MP:00053847.7C1QA, PRF1, MBD3, MBD1, MBD4
4MP:00053767.5IRF5, PRF1, MBD3, MBD4, TRIM21
5MP:00107687.4C1QA, PRF1, MBD3, MBD4, TRIM21

Publications for Cutaneous Lupus Erythematosus

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Articles related to Cutaneous Lupus Erythematosus:

(show top 50)    (show all 631)
idTitleAuthorsYear
1
FOXP3+ and CD39+ regulatory T cells in subtypes of cutaneous lupus erythematosus. (25808110)
2015
2
Beneficial effect of hydroxychloroquine on cutaneous lupus erythematosus in a Japanese girl. (24617496)
2014
3
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. (24520513)
2014
4
Mepacrine in Recalcitrant Cutaneous Lupus Erythematosus: Old-fashioned or Still Useful? (25474442)
2014
5
Cutaneous lupus erythematosus. (24623331)
2014
6
Characterization of clinical photosensitivity in cutaneous lupus erythematosus. (23648190)
2013
7
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
8
Cutaneous lupus erythematosus: clinical aspects and molecular pathogenesis. (23464352)
2013
9
TNF blockade and cutaneous lupus erythematosus: where do we stand and where are we going? (23902545)
2013
10
Cutaneous lupus erythematosus: diagnosis and treatment. (24238695)
2013
11
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (23157783)
2012
12
Periorbital edema as initial manifestation of chronic cutaneous lupus erythematosus. (22937197)
2012
13
Subacute Cutaneous Lupus Erythematosus Presenting in Childhood: A Case Report and Review of the Literature. (23106790)
2012
14
Effectiveness of topical calcineurin inhibitors as monotherapy or in combination with hydroxychloroquine in cutaneous lupus erythematosus. (21707772)
2012
15
Atypical subacute cutaneous lupus erythematosus presenting as lichen planus pemphigoides with autoantibodies to C-terminus of BP180, desmoglein 1 and SS-A/Ro antigen. (22413755)
2012
16
Consider drugs as a cause or an exacerbating factor in patients diagnosed with subacute cutaneous lupus erythematosus! (22835019)
2012
17
Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus. (21383913)
2011
18
Linear cutaneous lupus erythematosus on the midline of the face. (21352282)
2011
19
Familial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLE. (21132284)
2011
20
Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates. (20693199)
2010
21
Variable presentations of subacute cutaneous lupus erythematosus. (20642992)
2010
22
The impact of the EUSCLE Core Set Questionnaire for the assessment of cutaneous lupus erythematosus. (20693209)
2010
23
Prominent Degos-like skin lesions in a patient with chronic cutaneous lupus erythematosus. (20673533)
2010
24
Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. (19515045)
2009
25
Cutaneous lupus erythematosus mimicking multiple keratoacanthomas. (19106056)
2009
26
Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus. (19162247)
2009
27
Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus. (18811868)
2008
28
Terbinafine-induced subacute cutaneous lupus erythematosus. (18441768)
2008
29
Identification of type I interferon-associated inflammation in the pathogenesis of cutaneous lupus erythematosus opens up options for novel therapeutic approaches. (17437489)
2007
30
Failure of physiologic doses of pure UVA or UVB to induce lesions in photosensitive cutaneous lupus erythematosus: implications for phototesting. (17100736)
2006
31
Subacute cutaneous lupus erythematosus: 25-year evolution of a prototypic subset (subphenotype) of lupus erythematosus defined by characteristic cutaneous, pathological, immunological, and genetic findings. (15990071)
2005
32
Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. (15880822)
2005
33
Ro/SSA-positive cutaneous lupus erythematosus induced by carbamazepine. (15655159)
2005
34
Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus. (15115501)
2004
35
Thalidomide treatment for hypertrophic cutaneous lupus erythematosus. (15764048)
2004
36
Eleven cases of vesicular cutaneous lupus erythematosus in Shetland sheepdogs and rough collies: clinical management and prognosis. (14989704)
2004
37
Multiple, keratoacanthoma-like nodules on a 47-year-old man: a rare presentation of cutaneous lupus erythematosus. (14636190)
2003
38
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
39
Current treatment of cutaneous lupus erythematosus. (11328623)
2001
40
Erythema multiforme-like subacute cutaneous lupus erythematosus: a new variety? (11028873)
2000
41
The cutaneous pathology associated with seropositivity for antibodies to SSA (Ro): a clinicopathologic study of 23 adult patients without subacute cutaneous lupus erythematosus. (10218672)
1999
42
High-dose intravenous immunoglobulin in cutaneous lupus erythematosus. (10490126)
1999
43
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
44
Paraneoplastic subacute cutaneous lupus erythematosus: report of a case associated with cancer of the lung. (9094469)
1997
45
Rapid improvement of subacute cutaneous lupus erythematosus with low-dose methotrexate. (9187859)
1997
46
Histological detection of c-myb and c-myc proto-oncogene expression in infiltrating cells in cutaneous lupus erythematosus-like lesions of MRL/l mice by in situ hybridization. (1728975)
1992
47
A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus. (1430355)
1992
48
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
49
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
50
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. (7451656)
1981

Variations for Cutaneous Lupus Erythematosus

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Expression for genes affiliated with Cutaneous Lupus Erythematosus

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Search GEO for disease gene expression data for Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Cutaneous Lupus Erythematosus

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Compounds for genes affiliated with Cutaneous Lupus Erythematosus

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Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine439.5MBD4, MBD1
2cytosine43 2410.2MBD4, MBD1

GO Terms for genes affiliated with Cutaneous Lupus Erythematosus

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Biological processes related to Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:00516079.2PRF1, IRF5

Molecular functions related to Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1methyl-CpG bindingGO:00083279.3MBD1, MBD3
2protein bindingGO:00055156.4TRIM21, MBD4, MBD1, MBD3, PRF1, IRF5

Products for genes affiliated with Cutaneous Lupus Erythematosus

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Sources for Cutaneous Lupus Erythematosus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet