MCID: CTN003
MIFTS: 57

Cutaneous Lupus Erythematosus malady

Skin diseases category

Summaries for Cutaneous Lupus Erythematosus

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight.

MalaCards: Cutaneous Lupus Erythematosus, also known as lupus erythematosus, cutaneous, is related to lupus erythematosus and systemic lupus erythematosus, and has symptoms including warts/papillomas, skin photosensitivity and telangiectasiae of the skin. An important gene associated with Cutaneous Lupus Erythematosus is C1QA (complement component 1, q subcomponent, A chain), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Cytokine Network. The compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cutaneous Lupus Erythematosus

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 35MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
cutaneous lupus erythematosus:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

cutaneous lupus erythematosus 8 42 10 48
lupus erythematosus, cutaneous 42 60
lupus erythematosus cutaneous 44


External Ids:

Disease Ontology8 DOID:0050169
SNOMED-CT via Orphanet57 7119001
UMLS via Orphanet61 C0024137
ICD10 via Orphanet26 L93.0, L93.1, L93.2
MESH via Orphanet35 D008178

Related Diseases for Cutaneous Lupus Erythematosus

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cutaneous Lupus Erythematosus family:

Subacute Cutaneous Lupus Erythematosus

Diseases related to Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus32.2IFNA2, APOH
2systemic lupus erythematosus31.3CCR4, IFNA1, TNF, APOH, TROVE2, TRIM21
3arthritis30.7TNF
4rheumatoid arthritis30.7CCR4, CCL27, TNF, APOH, TRIM21, RNPC3
5dermatomyositis30.6TROVE2
6vasculitis30.6IFNA2, TNF, APOH, TRIM21
7psoriasis30.6KRT15, TNF, CCL27, CCL17, CCR4
8skin disease30.5PRF1, IFNA1
9lichen planus30.4IFNA2
10dermatitis30.4CCR4, CCL17, CCL27
11myositis30.4TRIM21, RNPC3
12mycosis fungoides30.4CCR4, CCL17, CCL27, IFNA2, IFNA1
13crohn's disease30.2TNF
14mixed connective tissue disease30.2APOH, RNPC3
15hepatitis30.2IFNA1, IFNA2, CCL27
16systemic scleroderma30.2ACE
17breast cancer30.2MBD4
18hepatitis b30.2CCL27, IFNA2, IFNA1, RNPC3
19connective tissue disease30.2IFNA1, TNF, APOH, TROVE2, TRIM21
20eosinophilia30.2IFNA2, CCL27, CCL17, CCR4
21sjogren's syndrome30.2CCL27, APOH, TROVE2, TRIM21, RNPC3
22melanoma30.2PRF1, TNF, IFNA1, IFNA2, CCR4
23subacute cutaneous lupus erythematosus10.5
24porphyria cutanea tarda10.4
25cutaneous porphyria10.4
26porphyria10.4
27complement deficiency10.4
28panniculitis10.4
29erythema multiforme10.3
30alopecia10.3
31keratoacanthoma10.3
32lymphadenitis10.3
33myasthenia gravis10.3
34squamous cell carcinoma10.3
35tinea corporis10.3
36acute pancreatitis10.1
37antiphospholipid syndrome10.1
38aggressive periodontitis10.1
39molluscum contagiosum10.1
40rosacea10.1
41hereditary angioedema10.1
42epidermolysis bullosa acquisita10.1
43keratoconjunctivitis sicca10.1
44inclusion body myositis10.1
45skin meningioma10.1
46pemphigus10.1
47pityriasis rubra pilaris10.1
48microphthalmia10.1
49localized scleroderma10.1
50sialadenitis10.1

Graphical network of the top 20 diseases related to Cutaneous Lupus Erythematosus:



Diseases related to cutaneous lupus erythematosus

Clinical Features for Cutaneous Lupus Erythematosus

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 21)
  • warts/papillomas
  • skin photosensitivity
  • telangiectasiae of the skin
  • irregular/in bands/reticular skin hyperpigmentation
  • cutaneous inflammation
  • cutaneous edema
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hyperkeratosis/ainhum/hyperkeratotic skin fissures
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • freezing lesions
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • psoriasis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • dermal/subcutaneous infiltration/induration

Drugs & Therapeutics for Cutaneous Lupus Erythematosus

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cutaneous Lupus Erythematosus

Drug clinical trials:

Search ClinicalTrials for Cutaneous Lupus Erythematosus

Search NIH Clinical Center for Cutaneous Lupus Erythematosus

Search CenterWatch for Cutaneous Lupus Erythematosus

Genetic Tests for Cutaneous Lupus Erythematosus

About this section

Anatomical Context for Cutaneous Lupus Erythematosus

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cutaneous Lupus Erythematosus:

32
Skin, T cells, Breast, Testes, Lung, Prostate, Brain, Thymus, Heart, B cells, Endothelial

Animal Models for Cutaneous Lupus Erythematosus or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cutaneous Lupus Erythematosus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053849.6MBD3, MBD4, MBD1, TNF, PRF1, TROVE2
2MP:00053879.2ACE, C1QA, CCR4, CCL17, MBD3, TNF

Publications for Cutaneous Lupus Erythematosus

About this section
Sources:
50PubMed
See all sources

Articles related to Cutaneous Lupus Erythematosus:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Evaluation of the quality of life of lupus erythematosus patients with cutaneous lesions in Japan. (24197553)
2014
2
Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus. (23896980)
2013
3
Epidemiological Characteristics of Patients With Cutaneous Lupus Erythematosus. (24380717)
2013
4
Drug-induced subacute cutaneous lupus erythematosus--filling the gap in knowledge: comment on "subacute cutaneous lupus erythematosus induced by chemotherapy". (23842706)
2013
5
Photoprotective habits of patients with cutaneous lupus erythematosus. (23360867)
2013
6
A difficult diagnosis: drug-induced subacute cutaneous lupus erythematosus (SCLE) triggered by omeprazole in a patient with pre-existing idiopathic SCLE. (22420369)
2012
7
Nonbullous neutrophilic lupus erythematosus: a newly recognized variant of cutaneous lupus erythematosus. (22050914)
2012
8
Subacute cutaneous lupus erythematosus associated with radioiodine treatment. (22369225)
2012
9
Golimumab-exacerbated subacute cutaneous lupus erythematosus. (23069957)
2012
10
Quality of life in cutaneous lupus erythematosus. (21397983)
2011
11
Efficacy of mycophenolate mofetil in antimalarial-resistant cutaneous lupus erythematosus. (21641078)
2011
12
Discoid lupus erythematosus as it relates to cutaneous squamous cell carcinoma and to photosensitivity. (23198469)
2011
13
Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus. (19712116)
2010
14
Remission of incapacitating acute cutaneous lupus erythematosus in a patient with systemic lupus erythematosus by B cell-depletive therapy. (20859218)
2010
15
Paraneoplastic toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus. (20518923)
2010
16
The cutaneous lupus disease activity and severity index as a validated outcome measure for cutaneous lupus erythematosus: comment on the article by Stamm et al. (18383405)
2008
17
Pathophysiology of cutaneous lupus erythematosus. (18094949)
2007
18
Subacute cutaneous lupus erythematosus presenting as erythroderma. (17459074)
2007
19
Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology. (17283583)
2007
20
A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus. (17195229)
2007
21
Paclitaxel-induced cutaneous lupus erythematosus in patients with serum anti-SSA/Ro antibody. (17584326)
2007
22
The dynamism of cutaneous lupus erythematosus: mild discoid lupus erythematosus evolving into SLE with SCLE and treatment-resistant lupus panniculitis. (16645776)
2007
23
Subacute cutaneous lupus erythematosus on the lines of Blaschko. (16709500)
2006
24
Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. (16511837)
2006
25
Treatment of refractory subacute cutaneous lupus erythematosus with efalizumab. (16635677)
2006
26
Terbinafine-induced subacute cutaneous lupus erythematosus. (16319476)
2006
27
Immunoglobulin M predominance in cutaneous lupus erythematosus. (15811120)
2005
28
Inhalation route inducing subacute cutaneous lupus erythematosus with tiotropium. (16027319)
2005
29
Clinical course and prognosis of cutaneous lupus erythematosus. (15234012)
2004
30
Discoid and subacute cutaneous lupus erythematosus: detection of differences in peripheral lymphocyte numbers. (11243649)
2000
31
Association of a promoter polymorphism of tumor necrosis factor-alpha with subacute cutaneous lupus erythematosus and distinct photoregulation of transcription. (10998151)
2000
32
Dapsone hypersensitivity syndrome in a patient with cutaneous lupus erythematosus. (10598771)
1999
33
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
34
Subacute cutaneous lupus erythematosus associated with chronic interstitial pneumonitis. (7607798)
1995
35
Subacute cutaneous lupus erythematosus associated with Hodgkin's disease. (8608690)
1995
36
The association of the two antimalarials chloroquine and quinacrine for treatment-resistant chronic and subacute cutaneous lupus erythematosus. (7873836)
1994
37
Systemic disease in subacute cutaneous lupus erythematosus: a controlled comparison with systemic lupus erythematosus. (7799346)
1994
38
Subacute cutaneous lupus erythematosus in a patient with inherited deficiency of the third component of complement. (1575540)
1992
39
Clinical, histologic, and immunofluorescent distinctions between subacute cutaneous lupus erythematosus and discoid lupus erythematosus. (1512459)
1992
40
Detection of anti-Ro(SSA) antibodies by gel double diffusion and a 'sandwich' ELISA in systemic and subacute cutaneous lupus erythematosus and SjAPgren's syndrome. (1903247)
1991
41
Response of discoid and subacute cutaneous lupus erythematosus to recombinant interferon alpha 2a. (2258631)
1990
42
IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. (2250107)
1990
43
Comparison of IgG subclass autoantibodies in patients with systemic lupus erythematosus and subacute cutaneous lupus erythematosus. (2085508)
1990
44
Subacute cutaneous lupus erythematosus during psoralen ultraviolet A therapy. (2306303)
1990
45
Metastatic malignant melanoma arising from a common blue nevus in a patient with subacute cutaneous lupus erythematosus. (2656327)
1989
46
Subacute cutaneous lupus erythematosus in Iceland. (2786859)
1989
47
A monoclonal Ro-antibody and the serum of a Ro-positive patient with subacute cutaneous lupus erythematosus (SCLE) react with basal layers of human epidermis. (3147897)
1988
48
Concurrence of subacute cutaneous lupus erythematosus and rheumatoid arthritis. (3964318)
1986
49
Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. (7451656)
1981
50
Concurrent localized scleroderma and discoid lupus erythematosus. Cutaneous 'mixed' or 'overlap' syndrome. (718182)
1978

Genetic Variations for Cutaneous Lupus Erythematosus

About this section

Expression for genes affiliated with Cutaneous Lupus Erythematosus

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Cutaneous Lupus Erythematosus.

Pathways for genes affiliated with Cutaneous Lupus Erythematosus

About this section
Sources:
53Reactome, 12EMD Millipore, 51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database
See all sources

Pathways related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
10.3IRF7, IFNA2
210.2TNF, IFNA1, IFNA2
3
Hide members
10.2IFNA2, IFNA1, IRF7
410.1CCR4, CCL17, CCL27
5
Hide members
10.1C1QA, TNF, TROVE2, TRIM21
6
Hide members
10.1IFNA2, IFNA1, TNF, PRF1
7
Hide members
10.1PRF1, TNF, IFNA1, IFNA2
810.1EEA1, TNF, IFNA1, IFNA2
9
Hide members
10.1TRIM21, IRF7, IFNA1, IFNA2
1010.1IFNA2, IFNA1, TNF, IRF7
11
Hide members
10.1IFNA2, IFNA1, TNF, IRF7
12
Hide members
10.1IRF7, TNF, IFNA1, IFNA2
13
Hide members
10.1IRF7, TNF, IFNA1, IFNA2
14
Hide members
10.0CCR4, CCL17, CCL27, IFNA1
15
Hide members
10.0TNF, IFNA1, IFNA2, CCL27, CCL17
16
Hide members
9.9ACE, IRF7, TNF, IFNA1, IFNA2, C1QA

Compounds for genes affiliated with Cutaneous Lupus Erythematosus

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1pegasys4410.7IFNA1, IFNA2
2entecavir4410.7IFNA2, IFNA1
3mizoribine4410.6IFNA2, IFNA1
4famciclovir44 1111.6IFNA2, IFNA1
5intron a4410.6IFNA2, IFNA1
6n-phosphonacetyl-l-aspartate4410.6IFNA2, IFNA1
7hydroxychloroquine44 1111.6IFNA2, TNF, APOH
8rantes4410.6IRF7, TNF, IFNA1
9imiquimod44 28 59 1113.6TNF, IFNA1, IFNA2
10infliximab44 49 1112.6IFNA2, TNF, APOH
11polyinosinic-polycytidylic acid4410.5IRF7, TNF, IFNA1
12etanercept44 49 1112.5C1QA, IFNA2, TNF, APOH
13poly(i-c)4410.5IRF7, TNF, IFNA1
14anagrelide44 1111.5IFNA2, IFNA1
15pentostatin44 59 28 1113.5IFNA2, IFNA1
16lomustine44 1111.5IFNA2, IFNA1
172,5-oligoadenylate4410.5IRF7, TNF, IFNA1, IFNA2
185-deoxy-5-fluorouridine4410.5IFNA1, IFNA2
19ifn-alpha4410.5IRF7, IFNA1, IFNA2
20melphalan44 1111.5IFNA2, IFNA1, TNF
21atpo44 2811.5APOH, IFNA1
22neopterin4410.5TNF, IFNA1, IFNA2
23rituximab44 49 1112.4C1QA, IFNA2, IFNA1, TNF, APOH
24ccl444 2811.4CCR4, CCL17, CCL27
25tarc4410.4TNF, CCL27, CCL17, CCR4
26prednisolone44 28 1112.4CCR4, IFNA2, IFNA1, TNF, APOH
27ccl344 2811.4CCR4, CCL17, CCL27, IFNA1, TNF
28superoxide44 2411.4IFNA2, TNF, APOH, PRF1, KRT15
29adefovir4410.3IFNA2, IFNA1
30thalidomide44 49 59 1113.3IFNA2, IFNA1, TNF
31alefacept44 1111.3TNF, C1QA
32chloroquine44 2 49 28 1114.3EEA1, TNF, IFNA1
33amantadine44 1111.3IFNA1, IFNA2
34efalizumab44 1111.2TNF, C1QA
35lipid4410.1CCR4, CCL27, IFNA2, TNF, APOH, ACE
36zinc44 2411.0EEA1, CCR4, IFNA2, MBD4, APOH, TROVE2
37cholesterol44 28 11 2412.7CCL27, APOH, PRF1, ACE, EEA1

GO Terms for genes affiliated with Cutaneous Lupus Erythematosus

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8CCL17, CCL27, IFNA2, TNF, PRF1, IL17F
2extracellular spaceGO:0056159.5ACE, CCL17, CCL27, IFNA2, TNF, APOH

Biological processes related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon productionGO:03247910.3TRIM21, IRF7
2inflammatory responseGO:0069549.9IL17F, TNF, IFNA2, CCL17, CCR4
3cell-cell signalingGO:0072679.8C1QA, CCL17, CCL27, IFNA2

Molecular functions related to Cutaneous Lupus Erythematosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.4EEA1, IFNA2, MBD3, MBD4, MBD1, TNF

Products for genes affiliated with Cutaneous Lupus Erythematosus

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Lupus Erythematosus

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet