MCID: CTN021
MIFTS: 45

Cutaneous Malignant Melanoma malady

Genetic category

Summaries for Cutaneous Malignant Melanoma

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33MalaCards
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MalaCards: Cutaneous Malignant Melanoma, also known as megalencephaly cutis marmorata telangiectatica congenita, is related to xeroderma pigmentosum and squamous cell carcinoma. An important gene associated with Cutaneous Malignant Melanoma is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)). The compounds alanine and fascaplysin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and pancreas, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cutaneous Malignant Melanoma

Sources:
61UMLS, 20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

cutaneous malignant melanoma 20
megalencephaly cutis marmorata telangiectatica congenita 61
familial atypical multiple mole-melanoma 61
dysplastic nevus syndrome 61
cutaneous melanoma 61


Related Diseases for Cutaneous Malignant Melanoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the melanoma, cutaneous malignant 8 family:

cutaneous malignant melanoma melanoma, cutaneous malignant, 1
melanoma, cutaneous malignant, 4 melanoma, cutaneous malignant, 9
melanoma, cutaneous malignant, 2 melanoma, cutaneous malignant, 3
melanoma, cutaneous malignant, 6 melanoma, cutaneous malignant, 5
melanoma, cutaneous malignant, 7

Diseases related to Cutaneous Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1xeroderma pigmentosum30.2XRCC3
2squamous cell carcinoma30.2MC1R, CDK4, CDKN2A, CEACAM1, XRCC3, HOXA1
3mycosis fungoides30.1CCL27, CCR10
4vitiligo30.1MLANA
5thyroid cancer30.1PTTG1
6melanoma, cutaneous malignant, 110.8
7macrocephaly-capillary malformation10.7
8melanoma, cutaneous malignant, 210.7
9megalencephaly-capillary malformation-polymicrogyria syndrome, somatic10.5
10megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome, somatic10.5
11n syndrome10.5
12pancreatic carcinoma, familial10.5
13dysplastic nevus syndrome10.5
14basal cell carcinoma10.5
15malignant breast melanoma10.4
16atypical mole syndrome10.4
17birt-hogg-dube syndrome10.4
18beckwith-wiedemann syndrome10.4
19birt–hogg–dubé syndrome10.4
20char syndrome10.4
21supernumerary nipples10.4
22birt-hogg-dub� syndrome10.4
23familial supernumerary nipples10.4
24familial melanoma10.4
25ocular melanoma10.4
26melanoma, cutaneous malignant, 910.4
27nevo syndrome10.3
28malignant conjunctiva melanoma10.3
29cdkn2a-related cutaneous malignant melanoma10.3
30cdk4-related cutaneous malignant melanoma10.3
31melanoma, cutaneous malignant 810.3
32melanoma, malignant, somatic10.3
33polycythemia vera10.1
34primary hyperparathyroidism10.1
35oculocutaneous albinism10.1
36primary polycythemia10.1
37gallbladder melanoma10.1
38albinism10.1
39micro syndrome10.1
40short syndrome10.1
41epidermal nevus10.1
42germ cell tumors10.1
43paraganglioma10.1
44xeroderma pigmentosum, group c10.1
45xeroderma pigmentosum, group a10.1
46xeroderma pigmentosum, group g10.1
47neurofibromatosis10.1
48amelanotic melanoma10.1
49nodular malignant melanoma10.1
50malignant eyelid melanoma10.1

Graphical network of the top 20 diseases related to Cutaneous Malignant Melanoma:



Diseases related to cutaneous malignant melanoma

Clinical Features for Cutaneous Malignant Melanoma

Drugs & Therapeutics for Cutaneous Malignant Melanoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cutaneous Malignant Melanoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Malignant Melanoma

Search NIH Clinical Center for Cutaneous Malignant Melanoma

Search CenterWatch for Cutaneous Malignant Melanoma

Genetic Tests for Cutaneous Malignant Melanoma

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20GeneTests
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Genetic tests related to Cutaneous Malignant Melanoma:

id Genetic test Affiliating Genes
1 Cutaneous Malignant Melanoma20 MC1R

Anatomical Context for Cutaneous Malignant Melanoma

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33MalaCards
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MalaCards organs/tissues related to Cutaneous Malignant Melanoma:

33
Whole blood, Lymph node, Pancreas, Thyroid, Breast, Skin, T cells, B cells, Endothelial

Animal Models for Cutaneous Malignant Melanoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Cutaneous Malignant Melanoma

Sources:
51PubMed
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Articles related to Cutaneous Malignant Melanoma:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Positron emission tomography in the follow-up of cutaneous malignant melanoma patients: a systematic review. (24380042)
2013
2
Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (24112097)
2013
3
Cutaneous malignant melanoma incidence rates in Norway. (23439631)
2013
4
Accuracy of real-time ultrasound elastography in the differential diagnosis of lymph nodes in cutaneous malignant melanoma (CMM): a pilot study. (23900625)
2013
5
Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling. (23704925)
2013
6
Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma. (22817475)
2013
7
Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients. (22153914)
2012
8
Dermal melanocytosis of the scalp associated to intracranial melanoma: malignant blue nevus, neurocutaneous melanosis, or neurocristic cutaneous hamartoma? (22123266)
2012
9
Adjunct primer for the use of national comprehensive cancer network guidelines for the surgical management of cutaneous malignant melanoma patients. (22483039)
2012
10
Primary cutaneous malignant melanoma in Ethiopian patients histopathologic study of 50 cases from Tikur Anbessa Hospital. (23409396)
2011
11
Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: a preliminary study. (20533551)
2011
12
Elevated risk of second primary cancer in patients with cutaneous malignant melanoma: a nationwide cohort study in Taiwan. (21036546)
2010
13
Correlation of cell cycle regulatory proteins (p53 and p16(ink)a8'(a)) and bcl-2 oncoprotein with mitotic index and thickness of primary cutaneous malignant melanoma. (21108607)
2010
14
Incidence and anatomic presentation of cutaneous malignant melanoma in central Canada during a 50-year period: 1956 to 2005. (19395122)
2009
15
Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma]. (17845760)
2007
16
Sun-related behavior after a diagnosis of cutaneous malignant melanoma. (17235242)
2007
17
CDKN2A germline mutations in individuals with cutaneous malignant melanoma. (17218939)
2007
18
The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study. (16896043)
2006
19
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients. (15751018)
2005
20
XPD gene polymorphism and host characteristics in the association with cutaneous malignant melanoma risk. (14735199)
2004
21
Invasive cutaneous malignant melanoma in Sweden, 1990-1999. A prospective, population-based study of survival and prognostic factors. (15372475)
2004
22
A retrospective observational study of primary cutaneous malignant melanoma patients treated with excision only compared with excision biopsy followed by wider local excision. (15030337)
2004
23
Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. (14996086)
2004
24
Breast metastases from cutaneous malignant melanoma. (15563866)
2004
25
Re: A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women. (14970285)
2004
26
Influence of fast lymphatic drainage on metastatic spread in cutaneous malignant melanoma: a prospective feasibility study. (12582814)
2003
27
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of cutaneous malignant melanoma. (12853340)
2003
28
Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. (12670917)
2003
29
Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. (14675394)
2003
30
Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. (11753047)
2002
31
The time from diagnostic excision biopsy to wide local excision for primary cutaneous malignant melanoma may not affect patient survival. (12100184)
2002
32
Lectin binding to cutaneous malignant melanoma: HPA is associated with metastasis formation. (11259098)
2001
33
Site-specific risk of cutaneous malignant melanoma and pattern of sun exposure in New Zealand. (10699940)
2000
34
Cutaneous malignant melanoma in children. (10968235)
2000
35
Contribution of whole body F-18-FDG-PET and lymphoscintigraphy to the assessment of regional and distant metastases in cutaneous malignant melanoma. A pilot study. (10834191)
2000
36
The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. (10723133)
2000
37
Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the Italian population: results of a collaborative case-control study. (10870052)
2000
38
Cancer surveillance series: changing patterns of cutaneous malignant melanoma mortality rates among whites in the United States. (10814676)
2000
39
Micropthalmia transcription factor: a new prognostic marker in intermediate-thickness cutaneous malignant melanoma. (11016620)
2000
40
Epidemiological characteristics of cutaneous malignant melanoma of the head and neck--a population-based study. (10665765)
1999
41
Value of neck dissection in the treatment of patients with intermediate-thickness cutaneous malignant melanoma of the head and neck. (9932599)
1999
42
Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma. (9817279)
1998
43
Expression of melan-A (MART1) in benign melanocytic nevi and primary cutaneous malignant melanoma. (9706977)
1998
44
Collision tumor of cutaneous malignant melanoma and basal cell carcinoma. (9793966)
1998
45
Cutaneous malignant melanoma in Scotland: incidence, survival, and mortality, 1979-94. The Scottish Melanoma Group. (9374883)
1997
46
Cutaneous malignant melanoma treated by Mohs surgery. Review of the treatment results of 179 cases from the Mohs Melanoma Registry. (9391564)
1997
47
Cutaneous malignant melanoma in women is uncommonly associated with a family history of melanoma in first-degree relatives: a case-control study. (9013481)
1996
48
Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene. (7668266)
1995
49
A Taqi RFLP of the human TGF alpha gene is significantly associated with cutaneous malignant melanoma. (2902017)
1988
50
Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma. (6409440)
1983

Genetic Variations for Cutaneous Malignant Melanoma

Expression for genes affiliated with Cutaneous Malignant Melanoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Malignant Melanoma

Search GEO for disease gene expression data for Cutaneous Malignant Melanoma.

Pathways for genes affiliated with Cutaneous Malignant Melanoma

Compounds for genes affiliated with Cutaneous Malignant Melanoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank
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Compounds related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine4510.8CCL27, CDKN2A, CDK4, MC1R, HOXA11, CEACAM1
2fascaplysin4510.7CDK4, CDKN2A
3phaeomelanin4510.7ASIP, MC1R
4retinoic acid45 2411.7FABP7, CDKN2A, CDK4, HOXA1, KIR2DS4, CEACAM1
5eumelanin4510.6ASIP, MC1R
6camptothecin45 60 1112.6CDK4, CDKN2A, XRCC3
7alpha msh4510.3ASIP, MC1R

GO Terms for genes affiliated with Cutaneous Malignant Melanoma

Sources:
16Gene Ontology
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Cellular components related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7CEACAM1, KIR2DS4, MC1R, MLANA, TNFRSF4, CCR10

Biological processes related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7IL12A, TNFRSF4, CCR10, CCL27
2positive regulation of smooth muscle cell apoptotic processGO:03439310.5IL12A, CDKN2A
3melanin biosynthetic processGO:04243810.3ASIP, MC1R

Products for genes affiliated with Cutaneous Malignant Melanoma

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  • Antibodies

Sources for Cutaneous Malignant Melanoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet