MCID: CTN021
MIFTS: 33

Cutaneous Malignant Melanoma malady

Genetic diseases category

Summaries for Cutaneous Malignant Melanoma

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MalaCards: Cutaneous Malignant Melanoma, also known as megalencephaly cutis marmorata telangiectatica congenita, is related to melanoma and pancreatic cancer. An important gene associated with Cutaneous Malignant Melanoma is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)). The compounds alanine and fascaplysin have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cutaneous Malignant Melanoma

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60UMLS, 20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

cutaneous malignant melanoma 20
megalencephaly cutis marmorata telangiectatica congenita 60
familial atypical multiple mole-melanoma 60
dysplastic nevus syndrome 60
cutaneous melanoma 60


Related Diseases for Cutaneous Malignant Melanoma

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17GeneCards, 18GeneDecks
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Diseases in the Melanoma, Cutaneous Malignant, 2 family:

cutaneous malignant melanoma Cdkn2a-Related Cutaneous Malignant Melanoma
Cdk4-Related Cutaneous Malignant Melanoma Melanoma, Cutaneous Malignant, 1
Melanoma, Cutaneous Malignant, 4 Melanoma, Cutaneous Malignant 8
Melanoma, Cutaneous Malignant, 9 Melanoma, Cutaneous Malignant, 3
Melanoma, Cutaneous Malignant, 6 Melanoma, Cutaneous Malignant, 5
Melanoma, Cutaneous Malignant, 7

Diseases related to Cutaneous Malignant Melanoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma32.2CEACAM1, CCR10, XRCC3, TNFRSF4, MLANA, CDKN2A
2pancreatic cancer30.5CDK4, CDKN2A, DKK1
3intraocular melanoma30.3MLANA, CDKN2A, CDK4, MC1R
4xeroderma pigmentosum30.1XRCC3
5breast cancer30.1XRCC3, FABP7, DKK1, CDKN2A, CDK4, MC1R
6squamous cell carcinoma30.1XRCC3, CDKN2A, CDK4, MC1R, HOXA1, FXYD5
7mycosis fungoides30.1CCR10, CCL27
8vitiligo30.1MLANA
9thyroid cancer30.1PTTG1
10hepatitis29.9CCL27, CEACAM1
11macrocephaly-capillary malformation10.7
12megalencephaly-capillary malformation-polymicrogyria syndrome, somatic10.7
13familial melanoma10.6
14skin melanoma10.6
15pancreatitis10.6
16megalencephaly-capillary malformation syndrome10.5
17dysplastic nevus syndrome10.5
18basal cell carcinoma10.4
19malignant breast melanoma10.4
20birt-hogg-dube syndrome10.3
21beckwith-wiedemann syndrome10.3
22choroiditis10.3
23malignant choroid melanoma10.3
24pigmented basal cell carcinoma10.2
25breast disease10.2
26cdkn2a-related cutaneous malignant melanoma10.2
27cdk4-related cutaneous malignant melanoma10.2
28melanoma, malignant, somatic10.2
29polycythemia vera10.1
30primary hyperparathyroidism10.1
31oculocutaneous albinism10.1
32primary polycythemia10.1
33gallbladder melanoma10.1
34hyperparathyroidism10.1
35polycythemia10.1
36albinism10.1
37neuronitis10.1
38paraganglioma10.1
39retinoblastoma10.1
40neurofibromatosis10.1
41malignant conjunctiva melanoma10.1
42eye carcinoma10.1
43amelanotic melanoma10.1
44nodular malignant melanoma10.1
45malignant eyelid melanoma10.1
46lichen planus10.1
47retinal melanoma10.1
48malignant cornea melanoma10.1
49clear cell sarcoma10.1
50gastroduodenitis10.1

Graphical network of the top 20 diseases related to Cutaneous Malignant Melanoma:



Diseases related to cutaneous malignant melanoma

Clinical Features for Cutaneous Malignant Melanoma

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Drugs & Therapeutics for Cutaneous Malignant Melanoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cutaneous Malignant Melanoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Malignant Melanoma

Search NIH Clinical Center for Cutaneous Malignant Melanoma

Search CenterWatch for Cutaneous Malignant Melanoma

Genetic Tests for Cutaneous Malignant Melanoma

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20GeneTests
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Genetic tests related to Cutaneous Malignant Melanoma:

id Genetic test Affiliating Genes
1 Cutaneous Malignant Melanoma20 MC1R

Anatomical Context for Cutaneous Malignant Melanoma

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Animal Models for Cutaneous Malignant Melanoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cutaneous Malignant Melanoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2CEACAM1, CCR10, TNFRSF4, DKK1, CDKN2A, CDK4
2MP:000538711.0CCR10, TNFRSF4, CDKN2A, CDK4, HOXA1, IL12A
3MP:000301211.0FABP7, MLANA, CDKN2A, MC1R, HOXA11, HOXA1
4MP:001076810.9DKK1, CDKN2A, CDK4, HOXA11, HOXA1, IL12A
5MP:000200610.8CDKN2A, CDK4, MC1R, ASIP, CEACAM1
6MP:000537910.8CDKN2A, CDK4, HOXA11, HOXA1, PTTG1, ASIP
7MP:000539710.7CCR10, TNFRSF4, CDKN2A, CDK4, HOXA1, PTTG1
8MP:000118610.4MLANA, CDKN2A, MC1R, ASIP

Publications for Cutaneous Malignant Melanoma

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Genetic Variations for Cutaneous Malignant Melanoma

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Expression for genes affiliated with Cutaneous Malignant Melanoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Malignant Melanoma

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Pathways for genes affiliated with Cutaneous Malignant Melanoma

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Compounds for genes affiliated with Cutaneous Malignant Melanoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alanine4410.8CCL27, CDKN2A, CDK4, MC1R, HOXA11, CEACAM1
2fascaplysin4410.7CDK4, CDKN2A
3phaeomelanin4410.7ASIP, MC1R
4retinoic acid44 2411.7FABP7, CDKN2A, CDK4, HOXA1, KIR2DS4, CEACAM1
5eumelanin4410.6ASIP, MC1R
6camptothecin44 59 1112.6CDK4, CDKN2A, XRCC3
7alpha msh4410.3ASIP, MC1R

GO Terms for genes affiliated with Cutaneous Malignant Melanoma

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16Gene Ontology
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Cellular components related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.7CEACAM1, KIR2DS4, MC1R, MLANA, TNFRSF4, CCR10

Biological processes related to Cutaneous Malignant Melanoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695510.7IL12A, TNFRSF4, CCR10, CCL27
2positive regulation of smooth muscle cell apoptotic processGO:03439310.5IL12A, CDKN2A
3melanin biosynthetic processGO:04243810.3ASIP, MC1R

Products for genes affiliated with Cutaneous Malignant Melanoma

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  • Antibodies
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  • Antibodies

Sources for Cutaneous Malignant Melanoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet