MCC
MCID: CTN026
MIFTS: 35

Cutaneous Neuroendocrine Carcinoma (MCC) malady

Skin diseases, Endocrine diseases, Cancer diseases, Neuronal diseases categories

Summaries for Cutaneous Neuroendocrine Carcinoma

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32MalaCards
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MalaCards: Cutaneous Neuroendocrine Carcinoma, also known as merkel cell carcinoma, is related to neuroendocrine carcinoma and squamous cell carcinoma. An important gene associated with Cutaneous Neuroendocrine Carcinoma is SYP (synaptophysin), and among its related pathways are Arf6 trafficking events and Heart Development. The compounds 111in-pentetreotide and etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Classifications for Cutaneous Neuroendocrine Carcinoma

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Endocrine diseases, Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
merkel cell carcinoma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

cutaneous neuroendocrine carcinoma 48
merkel cell carcinoma 48 60
mcc 48


External Ids:

SNOMED-CT via Orphanet57 254729005
ICD10 via Orphanet26 C44

Related Diseases for Cutaneous Neuroendocrine Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Cutaneous Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.0SYP, CHGA, CDH1, KRT20, ENO2
2squamous cell carcinoma30.9CTNNB1, SYP, CHGA, CDH1, KRT20, NOTCH1
3merkel cell carcinoma30.8SYP, CHGA, KRT20, ENO2
4large cell carcinoma30.8ENO2, KRT20, CHGA, SYP
5colorectal cancer30.8KRT20, CDH1, CTNNB1
6melanoma30.6ENO2, NOTCH1, CDH1, CTNNB1
7sarcoma30.6ENO2
8retinoblastoma30.6ENO2, SYP
9lung small cell carcinoma30.6SYP, CHGA, KRT20, ENO2
10transitional cell carcinoma30.5ENO2, KRT20, CDH1
11breast cancer30.3NOTCH1, CDH1, CTNNB1
12lung cancer30.3CHGA, CDH1, NOTCH1, ENO2
13pancreatic cancer30.2CTNNB1, SYP, CHGA
14somatostatinoma30.2CHGA
15rhabdomyosarcoma30.2ENO2
16neuroblastoma30.1ENO2, SYP
17pheochromocytoma30.1SYP, CHGA, ENO2
18paraganglioma30.1ENO2, CHGA, SYP
19endometrial carcinoma30.1CTNNB1, CDH1, KRT20
20kidney cancer30.1CDH1, KRT20, ENO2
21adenocarcinoma30.1CTNNB1, SYP, CHGA, CDH1, KRT20, NOTCH1
22neuroendocrine tumor30.1SYP, CHGA, KRT20, ENO2
23schizophrenia29.8SYP
24hypertension29.8NOTCH1
25chronic lymphocytic leukemia10.5
26leukemia10.5
27basal cell carcinoma10.5
28in situ carcinoma10.5
29thyroiditis10.5
30bone carcinoma10.4
31pancreatitis10.4
32dermatofibrosarcoma10.3
33lymphoepithelioma-like carcinoma10.3
34kaposi's sarcoma10.3
35adrenal carcinoma10.3
36epidermodysplasia verruciformis10.3
37myeloma10.3
38skin disease10.3
39merkel cell carcinoma, somatic10.3
40esophagitis10.2
41familial adenomatous polyposis10.1
42esophageal cancer10.1
433 methylcrotonyl-coa carboxylase 1 deficiency10.1
44cardiac tamponade10.1
45pancreatic endocrine carcinoma10.1
46actinic keratosis10.1
47psoriatic arthritis10.1
48pancytopenia10.1
49penile neoplasm10.1
50adult xanthogranuloma10.1

Graphical network of the top 20 diseases related to Cutaneous Neuroendocrine Carcinoma:



Diseases related to cutaneous neuroendocrine carcinoma

Clinical Features for Cutaneous Neuroendocrine Carcinoma

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Drugs & Therapeutics for Cutaneous Neuroendocrine Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cutaneous Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous Neuroendocrine Carcinoma

Search NIH Clinical Center for Cutaneous Neuroendocrine Carcinoma

Search CenterWatch for Cutaneous Neuroendocrine Carcinoma

Genetic Tests for Cutaneous Neuroendocrine Carcinoma

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Anatomical Context for Cutaneous Neuroendocrine Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Cutaneous Neuroendocrine Carcinoma:

32
Skin

Animal Models for Cutaneous Neuroendocrine Carcinoma or affiliated genes

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Publications for Cutaneous Neuroendocrine Carcinoma

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Genetic Variations for Cutaneous Neuroendocrine Carcinoma

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Expression for genes affiliated with Cutaneous Neuroendocrine Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Cutaneous Neuroendocrine Carcinoma.

Pathways for genes affiliated with Cutaneous Neuroendocrine Carcinoma

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 29KEGG, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Cutaneous Neuroendocrine Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB
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Compounds related to Cutaneous Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide4410.0SYP, CHGA
2etoposide44 49 59 1112.9CHGA, CDH1
3estracyt449.9ENO2, CHGA
4metanephrine44 2410.9CHGA, ENO2
5vanillylmandelic acid44 2410.8ENO2, CHGA
6lithium chloride449.8CTNNB1, CHGA
7chlorophyllin449.7CDH1, CTNNB1
8mibg449.6CHGA, ENO2
9smcc449.6ENO2, CHGA, SYP
10cyclopamine44 5910.6CDH1, CTNNB1
11s 100449.6ENO2, CHGA, SYP
12l-amino acid449.6ENO2, CHGA, SYP
13homovanillic acid44 2410.5ENO2, CHGA
14amine449.5SYP, CHGA, ENO2
15exisulind449.5CDH1, CTNNB1
16catecholamine449.5SYP, CHGA, ENO2
17sodium bisulfite449.4CTNNB1, CDH1
18mucicarmine449.4SYP, KRT20
19haloperidol44 28 2 49 1113.4CHGA, SYP, CTNNB1
205-hydroxytryptamine449.4ENO2, CHGA, SYP
21dopamine44 28 11 2412.3CTNNB1, CHGA, ENO2
22p002449.2CDH1, CHGA, CTNNB1
23methylcellulose449.2ENO2, CDH1, CTNNB1
24acth449.2SYP, CHGA, ENO2
25bromodeoxyuridine449.2CTNNB1, CHGA, ENO2
26mannitol44 1110.1CTNNB1, CDH1, ENO2
27silver449.1SYP, CHGA, CDH1, ENO2
28etodolac44 1110.0CDH1, CTNNB1
29creatinine449.0SYP, CHGA, CDH1, ENO2
30histamine44 28 2410.9CTNNB1, SYP, CHGA, CDH1
31genistein44 28 59 2 11 2413.9NOTCH1, CDH1, SYP, CTNNB1
32matrigel448.9CTNNB1, CHGA, CDH1, NOTCH1
33hyaluronic acid44 249.8CDH1, KRT20, ENO2
34glutamine448.8CTNNB1, SYP, CDH1, ENO2
35b 723448.8KRT20, CDH1, CHGA, SYP
36dexamethasone44 49 28 1111.8CTNNB1, CDH1, NOTCH1, ENO2
37aspartate448.6CTNNB1, CDH1, NOTCH1, ENO2
38cisplatin44 49 59 1111.4CTNNB1, SYP, CHGA, CDH1, ENO2
39doxorubicin44 49 1110.4CTNNB1, CDH1, KRT20, NOTCH1
40hematoxylin448.3ENO2, KRT20, CDH1, CHGA, SYP
41formaldehyde44 249.3SYP, CHGA, CDH1, KRT20, ENO2
42sucrose44 11 2410.2CTNNB1, SYP, CHGA, CDH1, KRT20
43glycogen44 249.0CTNNB1, SYP, CHGA, CDH1, NOTCH1, ENO2
44serine448.0CTNNB1, SYP, CHGA, CDH1, NOTCH1
45retinoic acid44 249.0CTNNB1, SYP, CHGA, CDH1, NOTCH1, ENO2
46paraffin447.6CTNNB1, SYP, CHGA, CDH1, KRT20, ENO2
47progesterone44 59 28 11 2411.6CTNNB1, SYP, CHGA, CDH1, KRT20, ENO2
48testosterone44 59 11 2410.6CTNNB1, SYP, CHGA, CDH1, KRT20, ENO2
49vegf447.2CTNNB1, SYP, CHGA, CDH1, KRT20, NOTCH1
50tyrosine447.2CTNNB1, SYP, CHGA, CDH1, KRT20, NOTCH1

GO Terms for genes affiliated with Cutaneous Neuroendocrine Carcinoma

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16Gene Ontology
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Cellular components related to Cutaneous Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.4CDH1, CTNNB1
2cell-cell adherens junctionGO:0059139.3CDH1, CTNNB1
3internal side of plasma membraneGO:0098989.2CTNNB1, CDH1
4lateral plasma membraneGO:0163289.0CDH1, CTNNB1
5cell junctionGO:0300549.0CDH1, SYP, CTNNB1

Biological processes related to Cutaneous Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of oligodendrocyte differentiationGO:0487159.5NOTCH1, CTNNB1
2cellular response to indole-3-methanolGO:0716819.5CDH1, CTNNB1
3cell fate specificationGO:0017089.5NOTCH1, CTNNB1
4regulation of protein localization to cell surfaceGO:20000089.5CDH1, CTNNB1
5hair follicle morphogenesisGO:0310699.5CTNNB1, NOTCH1
6embryonic hindlimb morphogenesisGO:0351169.4NOTCH1, CTNNB1
7forebrain developmentGO:0309009.4NOTCH1, CTNNB1
8epithelial to mesenchymal transitionGO:0018379.3NOTCH1, CTNNB1
9cellular component disassembly involved in execution phase of apoptosisGO:0069219.0CDH1, CTNNB1

Products for genes affiliated with Cutaneous Neuroendocrine Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cutaneous Neuroendocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet