CTCL
MCID: CTN015
MIFTS: 51

Cutaneous T Cell Lymphoma (CTCL) malady

Rare diseases, Cancer diseases, Immune diseases, Skin diseases, Blood diseases categories

Summaries for Cutaneous T Cell Lymphoma

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9Disease Ontology, 44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards: Cutaneous T Cell Lymphoma, also known as lymphoma, t-cell, cutaneous, is related to mycosis fungoides and graft versus host disease. An important gene associated with Cutaneous T Cell Lymphoma is IFNA2 (interferon, alpha 2), and among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Hematopoietic cell lineage. The drugs bexarotene and denileukin and the compounds mizoribine and pentostatin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node.

Disease Ontology:9 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS
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Classifications:



Aliases & Descriptions:

cutaneous t cell lymphoma 9 11
lymphoma, t-cell, cutaneous 63
cutaneous t-cell lymphoma 44
lymphoma t-cell cutaneous 46
ctcl 44


External Ids:

Disease Ontology9 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

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18GeneCards, 19GeneDecks
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Diseases in the Cutaneous T Cell Lymphoma family:

Primary Cutaneous Gamma/delta-Positive T-Cell Lymphoma

Diseases related to Cutaneous T Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides31.4IFNA2, IL2RA, IL7, CCL17, PLS3
2graft versus host disease30.8IL2RA, IL7
3psoriasis30.6IL2RA, IL7, KIR2DL3, CCL17
4sezary's disease30.4IL7, IL2RA, PLS3, IFNA2
5hairy cell leukemia30.4IFNA2, IL2RA
6bullous pemphigoid30.3IL7, CCL17
7hepatitis c30.3IL7, IFNA2, KIR2DL3
8ulcerative colitis30.3IL2RA, CCL17, IL7
9thrombocytopenia30.3IFNA2, IL7
10rheumatoid arthritis30.2IL2RA, IL7, KIR2DL1, ANG
11melanoma30.0KIR2DL1, IL7, ANG, IFNA2
12dermatitis10.8
13lymphomatoid papulosis10.7
14leukemia10.6
15atopic dermatitis10.6
16parapsoriasis10.5
17t-cell leukemia10.5
18pityriasis lichenoides10.5
19adult t-cell leukemia10.5
20follicular mucinosis10.4
21pityriasis lichenoides chronica10.4
22chronic actinic dermatitis10.4
23pyoderma gangrenosum10.3
24porokeratosis10.3
25capillary leak syndrome10.3
26chronic lymphocytic leukemia10.3
27dermatitis herpetiformis10.3
28fasciitis10.3
29pneumonia10.3
30pyoderma10.3
31vasculitis10.3
32xanthomatosis10.3
33b-cell lymphomas10.3
34chronic graft versus host disease10.3
35eosinophilic fasciitis10.3
36hydroa vacciniforme10.3
37peripheral t-cell lymphoma10.3
38hematopoietic stem cell transplantation10.3
39tropical spastic paraparesis10.2
40chronic eosinophilic pneumonia10.2
41protein s deficiency10.2
42measles10.2
43hypercalcemia10.2
44epidermodysplasia verruciformis10.2
45diphtheria10.2
46spongiotic dermatitis10.2
47cerebritis10.2
48composite lymphoma10.2
49wolf-hirschhorn syndrome10.2
50verrucous carcinoma10.2

Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Symptoms for Cutaneous T Cell Lymphoma

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Drugs & Therapeutics for Cutaneous T Cell Lymphoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cutaneous T Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous T Cell Lymphoma

Search NIH Clinical Center for Cutaneous T Cell Lymphoma

Search CenterWatch for Cutaneous T Cell Lymphoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cutaneous T Cell Lymphoma

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Anatomical Context for Cutaneous T Cell Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Cutaneous T Cell Lymphoma:

34
T cells, Skin, Lymph node, B cells, Bone, Testis, Nk cells, Monocytes, Testes, Bone marrow, Lung, Colon, Heart, Thymus, Endothelial

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

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Publications for Cutaneous T Cell Lymphoma

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53PubMed
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Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 687)
idTitleAuthorsYear
1
Novel therapies for cutaneous T-cell lymphoma: what does the future hold? (24397291)
2014
2
Romidepsin for cutaneous T-cell lymphoma. (24295412)
2013
3
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
4
Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum. (23331699)
2013
5
Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma. (22948508)
2013
6
Comparison of pegylated interferon I+-2b plus psoralen PUVA versus standard interferon I+-2a plus PUVA in patients with cutaneous T-cell lymphoma. (22168776)
2012
7
Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma. (22459529)
2012
8
Integrated positron-emission tomography and computed tomography manifestations of cutaneous T-cell lymphoma. (23247490)
2012
9
Low herpesvirus entry mediator (HVEM) expression on dermal fibroblasts contributes to a Th2-dominant microenvironment in advanced cutaneous T-cell lymphoma. (22297640)
2012
10
Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. (22457602)
2012
11
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. (22383798)
2012
12
Photopheresis in the treatment of cutaneous T-cell lymphoma: current status. (22157241)
2012
13
The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T-cell lymphoma patients. (22367792)
2012
14
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. (22048239)
2011
15
Synergistic enhancement of cellular immune responses by the novel Toll receptor 7/8 agonist 3M-007 and interferon-I^: implications for therapy of cutaneous T-cell lymphoma. (21942329)
2011
16
Romidepsin in the treatment of cutaneous T-cell lymphoma. (22287862)
2011
17
The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma. (22236880)
2011
18
Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomas. (21872828)
2011
19
Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage. (20625418)
2010
20
Posttransplant cutaneous T-cell lymphoma: case reports and review of the association of calcineurin inhibitor use with posttransplant lymphoproliferative disease risk. (20479299)
2010
21
Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. (20888065)
2010
22
Primary cutaneous T-cell lymphoma following organ transplantation in a 16-year-old boy. (19250431)
2009
23
Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: clinicopathological analysis of 27 patients. (19018763)
2009
24
Extracorporeal methoxsalen: new drug. Cutaneous T cell lymphoma: for rare patients, but better assessment needed. (19388212)
2009
25
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. (19258503)
2009
26
SAczary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. (18033314)
2008
27
U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. (18241274)
2008
28
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents. (18245554)
2008
29
FDG-PET/CT for the evaluation of response to therapy of cutaneous T-cell lymphoma to vorinostat (suberoylanilide hydroxamic acid, SAHA) in a phase II trial. (18665425)
2008
30
T-cell receptor-gamma gene analysis in evolving to advancing cutaneous T-cell lymphoma. (17680965)
2007
31
Cutaneous T-cell lymphoma. (16720231)
2006
32
Treatment of cutaneous T-cell lymphoma with retinoids. (17014481)
2006
33
Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL). (16516674)
2006
34
Activation of neutrophils in cutaneous T-cell lymphoma. (16322281)
2005
35
CCR10 is expressed in cutaneous T-cell lymphoma. (15700309)
2005
36
Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. (15514008)
2005
37
Serological immunomarkers in cutaneous T cell lymphoma. (15539892)
2004
38
CD26 expression on cutaneous infiltrates from patients with cutaneous T-cell lymphoma (CTCL) CD26 in cutaneous T-cell lymphoma patients. (12675243)
2003
39
T cell receptor gamma-chain gene polymerase chain reaction to diagnose central nervous system involvement by cutaneous T cell lymphoma. (11986404)
2002
40
Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. (11675351)
2001
41
Functional inhibitory receptors expressed by a cutaneous T cell lymphoma-specific cytolytic clonal T cell population. (11121132)
2000
42
Activity of pentostatin (Nipent) in cutaneous T-cell lymphoma: single-agent and combination studies. (10877054)
2000
43
Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells. (9864169)
1999
44
Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. (9176388)
1997
45
A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma. (8668164)
1996
46
Interferon-inducible protein-10 and the pathogenesis of cutaneous T-cell lymphomas. (9049966)
1996
47
Chronic actinic dermatitis. An immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. (7802165)
1994
48
Costimulation of cutaneous T-cell lymphoma cells by interleukin-7 and interleukin-2: potential autocrine or paracrine effectors in the SAczary syndrome. (8113839)
1994
49
Cutaneous T-cell lymphoma with porokeratosis-like lesions. (1517498)
1992
50
Interferon alpha and etretinate combination treatment of cutaneous T-cell lymphoma. (2258637)
1990

Variations for Cutaneous T Cell Lymphoma

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Expression for genes affiliated with Cutaneous T Cell Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous T Cell Lymphoma

Search GEO for disease gene expression data for Cutaneous T Cell Lymphoma.

Pathways for genes affiliated with Cutaneous T Cell Lymphoma

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51PathCards, 56Reactome, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KIR2DL1, KIR2DL3
29.6IL2RA, IL7
3
Show member pathways
9.6IL7, IL2RA
4
Show member pathways
Immune response CD16 signaling in NK cells61
9.4IFNA2, KIR2DL1, KIR2DL3
59.3IL7, IL2RA, IFNA2
6
Show member pathways
9.3IL7, IL2RA, IFNA2
7
Show member pathways
Type III interferon signaling39
9.3IL2RA, IL7, IFNA2
8
Show member pathways
9.0IL2RA, IFNA2, KIR2DL3, KIR2DL1
9
Show member pathways
8.8IL7, IL2RA, CCL17
10
Show member pathways
8.8CCL17, IL2RA, IL7
11
Show member pathways
8.5IL7, IL2RA, IFNA2, CCL17
12
Show member pathways
8.5CCL17, IFNA2, IL2RA, IL7

Compounds for genes affiliated with Cutaneous T Cell Lymphoma

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1mizoribine4610.2IL2RA, IFNA2
2pentostatin46 62 30 1213.2IFNA2, IL2RA
3hydroxychloroquine46 1211.1IL2RA, IFNA2
4megestrol acetate4610.1IL2RA, IFNA2
5levamisole46 1211.1IFNA2, IL2RA
6lamivudine46 52 1212.1IL2RA, IFNA2
7con a4610.1IFNA2, IL2RA
8diethyl dithiocarbamate4610.1IL2RA, IFNA2
92,5-oligoadenylate4610.1IL2RA, IFNA2
10infliximab46 52 1212.0IFNA2, IL2RA
11erythromycin46 3 52 1213.0IL2RA, IFNA2
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4610.0IL7, IFNA2
13c-d4t4610.0IL7, IL2RA
14ifn-alpha4610.0IFNA2, IL2RA
15basiliximab46 1211.0IL2RA, IL7
16betacarotene4610.0IL2RA, IFNA2
17okt34610.0IL7, IL2RA
18neopterin4610.0IL2RA, IFNA2
19rituximab46 52 1211.9IFNA2, IL2RA
20bleomycin46 1210.9IFNA2, IL2RA
21thalidomide46 52 62 1212.8IL2RA, IFNA2
22vitamin-e469.7IL2RA, IFNA2
23vincristine46 52 1211.7IL2RA, IFNA2
24cyclophosphamide46 52 1211.7IFNA2, IL2RA, IL7
25azathioprine46 3 52 1212.6IFNA2, IL2RA
26histamine46 30 2511.6IFNA2, IL2RA, IL7
27doxorubicin46 52 1211.6IFNA2, IL2RA, IL7
28neomycin469.5IL7, ANG
29thymidine46 2510.5IFNA2, IL2RA, IL7
30ccl446 3010.5IL7, CCL17
31alpha tocopherol469.4IL2RA, IFNA2
32allergens469.4IL7, CCL17
33il 10469.2IL7, IL2RA, CCL17
34tacrolimus46 52 1211.2IL7, IL2RA, CCL17
35rantes469.2CCL17, IL2RA, IL7
36cyclosporin a46 30 6211.1IL7, IL2RA, CCL17
37vegf469.0IL7, IL2RA, IFNA2, ANG
38tyrosine468.4ANG, IFNA2, IL2RA, IL7, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

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17Gene Ontology
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Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3IL7, IFNA2, CCL17, ANG

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.8KIR2DL1, KIR2DL3
2positive regulation of T cell differentiationGO:0455829.5IL2RA, IL7
3cell-cell signalingGO:0072678.6IL7, IFNA2, CCL17
4immune responseGO:0069558.5KIR2DL1, KIR2DL3, IL2RA, CCL17

Products for genes affiliated with Cutaneous T Cell Lymphoma

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Sources for Cutaneous T Cell Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet