CTCL
MCID: CTN015
MIFTS: 44

Cutaneous T Cell Lymphoma (CTCL) malady

Immune diseases category

Summaries for Cutaneous T Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards: Cutaneous T Cell Lymphoma, also known as lymphoma, t-cell, cutaneous, is related to mycosis fungoides and dermatitis. An important gene associated with Cutaneous T Cell Lymphoma is ZNF638 (zinc finger protein 638). The drugs bexarotene and denileukin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node.

Disease Ontology:8 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

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8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

cutaneous t cell lymphoma 8 10
lymphoma, t-cell, cutaneous 60
cutaneous t-cell lymphoma 42
lymphoma t-cell cutaneous 44
ctcl 42


External Ids:

Disease Ontology8 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Clinical Features for Cutaneous T Cell Lymphoma

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Drugs & Therapeutics for Cutaneous T Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cutaneous T Cell Lymphoma

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Anatomical Context for Cutaneous T Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Cutaneous T Cell Lymphoma:

32
T cells, Skin, Lymph node, B cells, Bone, Monocytes, Testis, Bone marrow, Colon, Lung, Liver, Testes, Nk cells, Heart, Thymus, Endothelial

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

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Publications for Cutaneous T Cell Lymphoma

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50PubMed
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Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 811)
idTitleAuthorsYear
1
Connecting the dots in cutaneous T cell lymphoma (CTCL): STAT5 regulates malignant T cell proliferation via miR-155. (23803726)
2013
2
Increased frequency of skin-infiltrating FoxP3+ regulatory T cells as a diagnostic indicator of severe atopic dermatitis from cutaneous T cell lymphoma. (23600840)
2013
3
Role of bexarotene in the treatment of cutaneous T-cell lymphoma: the clinical and immunological sides. (23557425)
2013
4
Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis. (22404649)
2013
5
Central Nervous System Involvement in Cutaneous T-Cell Lymphoma: 2 Illustrative Cases and a Review of Current Literature. (24262331)
2013
6
The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous I^I' T-cell lymphoma may mimic those of rheumatic diseases: a report of 11 cases. (23588884)
2013
7
Extracorporeal photopheresis for the treatment of erythrodermic cutaneous T-cell lymphoma: a single center clinical experience with long-term follow-up data and a brief overview of the literature. (23786842)
2013
8
Aprepitant in the Treatment of Refractory Pruritus Secondary to Cutaneous T-Cell Lymphoma. (24139470)
2013
9
Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland. (22678563)
2012
10
Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells. (21949767)
2011
11
Lymphoma-associated hemophagocytic syndrome (LAHS) in advanced-stage mycosis fungoides/SAczary syndrome cutaneous T-cell lymphoma. (21550694)
2011
12
Telomerase-specific GV1001 peptide vaccination fails to induce objective tumor response in patients with cutaneous T cell lymphoma. (21377838)
2011
13
Malignant cutaneous T-cell lymphoma cells express IL-17 utilizing the Jak3/Stat3 signaling pathway. (21346774)
2011
14
Cutaneous involvement by colonic extranodal NK/T-cell lymphoma mimicking mycosis fungoides: a case report*. (21883363)
2011
15
Multicenter phase II trial of enzastaurin in patients with relapsed or refractory advanced cutaneous T-cell lymphoma. (21649541)
2011
16
Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant. (19903173)
2010
17
T-cell receptor gamma gene rearrangement in cutaneous T-cell lymphoma: comparative study of polymerase chain reaction with denaturing gradient gel electrophoresis and GeneScan analysis. (19906072)
2010
18
The use of synchrotron infrared microspectroscopy in the assessment of cutaneous T-cell lymphoma vs. pityriasis lichenoides chronica. (20415741)
2010
19
Extracorporeal methoxsalen: new drug. Cutaneous T cell lymphoma: for rare patients, but better assessment needed. (19388212)
2009
20
Total scalp radiation using image-guided IMRT for progressive cutaneous T cell lymphoma. (19451312)
2009
21
Canine epitheliotropic cutaneous T-cell lymphoma: an investigation of T-cell receptor immunophenotype, lesion topography and molecular clonality. (20178496)
2009
22
Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma. (19079651)
2009
23
Cutaneous involvement in the lymphoepithelioid variant of peripheral T-cell lymphoma, unspecified (Lennert lymphoma). Report of a case and review of the literature. (19775391)
2009
24
Strategies for treating cutaneous T-cell lymphoma: part 1: remission. (20729945)
2009
25
Vorinostat for the treatment of bullous pemphigoid in the setting of advanced, refractory cutaneous T-cell lymphoma. (19770436)
2009
26
Denileukin diftitox for the treatment of cutaneous T-cell lymphoma. (19707452)
2008
27
Immune function abnormalities in peripheral blood mononuclear cell cytokine expression differentiates stages of cutaneous T-cell lymphoma/mycosis fungoides. (18245523)
2008
28
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. (18628465)
2008
29
Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma. (17239936)
2007
30
Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat. (19707308)
2007
31
ECP versus PUVA for the treatment of cutaneous T-cell lymphoma. (17609808)
2007
32
Folliculotropic SAczary syndrome: a new variant of cutaneous T-cell lymphoma. (17286634)
2007
33
Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL). (16516674)
2006
34
Resistance to activation-induced cell death and bystander cytotoxicity via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas. (15816832)
2005
35
Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas. (15531468)
2004
36
The life cycle of cutaneous T cell lymphoma reveals opportunities for targeted drug therapy. (15578918)
2004
37
Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL). (15507390)
2004
38
Overview of cutaneous T-cell lymphoma: prognostic factors and novel therapeutic approaches. (15202526)
2003
39
Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. (12006543)
2002
40
Follicular mucinosis associated with early stage cutaneous T-cell lymphoma: successful treatment with interferon alpha-2b and acitretin. (12243671)
2001
41
Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. (11298531)
2001
42
Constitutive and interleukin-7- and interleukin-15-stimulated DNA binding of STAT and novel factors in cutaneous T cell lymphoma cells. (11564163)
2001
43
Interleukin-2 fusion toxin: targeted therapy for cutaneous T cell lymphoma. (11594570)
2001
44
IL-15 and IL-16 overexpression in cutaneous T-cell lymphomas: stage-dependent increase in mycosis fungoides progression. (10949545)
2000
45
Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. (9176388)
1997
46
CD44 variant expression in cutaneous T-cell lymphoma. (9243361)
1997
47
p53 and bcl-2 expression do not correlate with prognosis in primary cutaneous large T-cell lymphomas. (9331891)
1997
48
Malignant and normal T cells show random use of T-cell receptor alpha chain variable regions in patients with cutaneous T-cell lymphoma. (7615977)
1995
49
Concurrent eosinophilic fasciitis and cutaneous T-cell lymphoma. Eosinophilic fasciitis as a paraneoplastic syndrome of T-cell malignant neoplasms? (2036034)
1991
50
Lymphomatoid papulosis, cutaneous T-cell lymphoma, and Hodgkin's disease: diseases of activated helper T cells? (2879806)
1986

Genetic Variations for Cutaneous T Cell Lymphoma

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Expression for genes affiliated with Cutaneous T Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous T Cell Lymphoma

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Pathways for genes affiliated with Cutaneous T Cell Lymphoma

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Compounds for genes affiliated with Cutaneous T Cell Lymphoma

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GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

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16Gene Ontology
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Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular_componentGO:00557510.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biological_processGO:00815010.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Products for genes affiliated with Cutaneous T Cell Lymphoma

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Sources for Cutaneous T Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet