CTCL
MCID: CTN015
MIFTS: 51

Cutaneous T Cell Lymphoma (CTCL) malady

Rare diseases, Cancer diseases, Immune diseases, Skin diseases, Blood diseases categories
Download this MalaCard

Summaries for Cutaneous T Cell Lymphoma

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards based summary: Cutaneous T Cell Lymphoma, also known as lymphoma, t-cell, cutaneous, is related to graft versus host disease and mycosis fungoides. An important gene associated with Cutaneous T Cell Lymphoma is IFNA2 (interferon, alpha 2), and among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Hematopoietic cell lineage. The drugs bexarotene and denileukin and the compounds mizoribine and pentostatin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node.

Disease Ontology:8 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

About this section

Cutaneous T Cell Lymphoma, Aliases & Descriptions:

Name: Cutaneous T Cell Lymphoma 8 10
Lymphoma, T-Cell, Cutaneous 62
Cutaneous T-Cell Lymphoma 42
 
Lymphoma T-Cell Cutaneous 44
Ctcl 42


Classifications:



External Ids:

Disease Ontology8 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

About this section

Diseases in the Cutaneous T Cell Lymphoma family:

Primary Cutaneous Gamma/delta-Positive T-Cell Lymphoma

Diseases related to Cutaneous T Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1graft versus host disease31.0IL2RA, IL7
2mycosis fungoides31.0IFNA2, IL2RA, IL7, CCL17, PLS3
3hairy cell leukemia30.7IFNA2, IL2RA
4chronic lymphocytic leukemia30.6IL2RA, IL7
5bullous pemphigoid30.5IL7, CCL17
6sezary's disease30.5IL7, IL2RA, PLS3, IFNA2
7hepatitis c30.4IL7, IFNA2, KIR2DL3
8psoriasis30.4IL2RA, IL7, KIR2DL3, CCL17
9ulcerative colitis30.3IL2RA, CCL17, IL7
10thrombocytopenia30.2IFNA2, IL7
11rheumatoid arthritis29.8IL2RA, IL7, KIR2DL1, ANG
12melanoma29.7KIR2DL1, IL7, ANG, IFNA2
13dermatitis10.8
14lymphomatoid papulosis10.7
15leukemia10.6
16atopic dermatitis10.6
17parapsoriasis10.6
18pityriasis lichenoides10.6
19t-cell leukemia10.5
20hydroa vacciniforme10.5
21adult t-cell leukemia10.4
22follicular mucinosis10.4
23pityriasis lichenoides chronica10.4
24chronic actinic dermatitis10.4
25b-cell lymphomas10.4
26hematopoietic stem cell transplantation10.4
27peripheral t-cell lymphoma10.4
28capillary leak syndrome10.4
29pyoderma gangrenosum10.4
30porokeratosis10.4
31dermatitis herpetiformis10.4
32fasciitis10.4
33pneumonia10.4
34pyoderma10.4
35vasculitis10.4
36xanthomatosis10.4
37chronic graft versus host disease10.4
38eosinophilic fasciitis10.4
39systemic mastocytosis10.3IFNA2, IL2RA
40splenomegaly10.3IFNA2, IL2RA
41mastocytosis10.3IL2RA, IFNA2
4221-hydroxylase deficiency10.3IL2RA, IFNA2
43hepatitis b10.2IFNA2, IL2RA
44uveitis10.2IFNA2, IL2RA
45acute lymphocytic leukemia10.2
46alopecia10.2
47arthritis10.2
48chronic inflammatory demyelinating polyneuropathy10.2
49congestive heart failure10.2
50hepatitis10.2

Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Symptoms for Cutaneous T Cell Lymphoma

About this section

Drugs & Therapeutics for Cutaneous T Cell Lymphoma

About this section

Drug clinical trials:

Search ClinicalTrials for Cutaneous T Cell Lymphoma

Search NIH Clinical Center for Cutaneous T Cell Lymphoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cutaneous T Cell Lymphoma

About this section

Anatomical Context for Cutaneous T Cell Lymphoma

About this section

MalaCards organs/tissues related to Cutaneous T Cell Lymphoma:

32
T cells, Skin, Lymph node, B cells, Bone, Neutrophil, Bone marrow, Testis, Monocytes, Thymus, Heart, Colon, Liver, Lung, Testes, Nk cells, Endothelial

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

About this section

Publications for Cutaneous T Cell Lymphoma

About this section

Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 721)
idTitleAuthorsYear
1
Phase II evaluation of VDC-1101 in canine cutaneous T-cell lymphoma. (25274443)
2014
2
Novel therapies for cutaneous T-cell lymphoma: what does the future hold? (24397291)
2014
3
Romidepsin for cutaneous T-cell lymphoma. (24295412)
2013
4
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
5
Expression of miR-155 and miR-126 in situ in cutaneous T-cell lymphoma. (24033365)
2013
6
Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum. (23331699)
2013
7
Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma. (22948508)
2013
8
Comparison of pegylated interferon I+-2b plus psoralen PUVA versus standard interferon I+-2a plus PUVA in patients with cutaneous T-cell lymphoma. (22168776)
2012
9
Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma. (22459529)
2012
10
Integrated positron-emission tomography and computed tomography manifestations of cutaneous T-cell lymphoma. (23247490)
2012
11
Low herpesvirus entry mediator (HVEM) expression on dermal fibroblasts contributes to a Th2-dominant microenvironment in advanced cutaneous T-cell lymphoma. (22297640)
2012
12
Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. (22457602)
2012
13
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. (22383798)
2012
14
Photopheresis in the treatment of cutaneous T-cell lymphoma: current status. (22157241)
2012
15
The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T-cell lymphoma patients. (22367792)
2012
16
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. (22048239)
2011
17
Synergistic enhancement of cellular immune responses by the novel Toll receptor 7/8 agonist 3M-007 and interferon-I^: implications for therapy of cutaneous T-cell lymphoma. (21942329)
2011
18
Romidepsin in the treatment of cutaneous T-cell lymphoma. (22287862)
2011
19
The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma. (22236880)
2011
20
Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomas. (21872828)
2011
21
Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage. (20625418)
2010
22
Posttransplant cutaneous T-cell lymphoma: case reports and review of the association of calcineurin inhibitor use with posttransplant lymphoproliferative disease risk. (20479299)
2010
23
Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. (20888065)
2010
24
Primary cutaneous T-cell lymphoma following organ transplantation in a 16-year-old boy. (19250431)
2009
25
Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: clinicopathological analysis of 27 patients. (19018763)
2009
26
Extracorporeal methoxsalen: new drug. Cutaneous T cell lymphoma: for rare patients, but better assessment needed. (19388212)
2009
27
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. (19258503)
2009
28
SAczary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. (18033314)
2008
29
U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. (18241274)
2008
30
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents. (18245554)
2008
31
T-cell receptor-gamma gene analysis in evolving to advancing cutaneous T-cell lymphoma. (17680965)
2007
32
Cutaneous T-cell lymphoma. (16720231)
2006
33
Treatment of cutaneous T-cell lymphoma with retinoids. (17014481)
2006
34
Activation of neutrophils in cutaneous T-cell lymphoma. (16322281)
2005
35
CCR10 is expressed in cutaneous T-cell lymphoma. (15700309)
2005
36
Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. (15514008)
2005
37
Serological immunomarkers in cutaneous T cell lymphoma. (15539892)
2004
38
CD26 expression on cutaneous infiltrates from patients with cutaneous T-cell lymphoma (CTCL) CD26 in cutaneous T-cell lymphoma patients. (12675243)
2003
39
T cell receptor gamma-chain gene polymerase chain reaction to diagnose central nervous system involvement by cutaneous T cell lymphoma. (11986404)
2002
40
Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. (11675351)
2001
41
Functional inhibitory receptors expressed by a cutaneous T cell lymphoma-specific cytolytic clonal T cell population. (11121132)
2000
42
Activity of pentostatin (Nipent) in cutaneous T-cell lymphoma: single-agent and combination studies. (10877054)
2000
43
Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells. (9864169)
1999
44
Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. (9176388)
1997
45
A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma. (8668164)
1996
46
Interferon-inducible protein-10 and the pathogenesis of cutaneous T-cell lymphomas. (9049966)
1996
47
Chronic actinic dermatitis. An immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. (7802165)
1994
48
Costimulation of cutaneous T-cell lymphoma cells by interleukin-7 and interleukin-2: potential autocrine or paracrine effectors in the SAczary syndrome. (8113839)
1994
49
Cutaneous T-cell lymphoma with porokeratosis-like lesions. (1517498)
1992
50
Interferon alpha and etretinate combination treatment of cutaneous T-cell lymphoma. (2258637)
1990

Variations for Cutaneous T Cell Lymphoma

About this section

Expression for genes affiliated with Cutaneous T Cell Lymphoma

About this section
Expression patterns in normal tissues for genes affiliated with Cutaneous T Cell Lymphoma

Search GEO for disease gene expression data for Cutaneous T Cell Lymphoma.

Pathways for genes affiliated with Cutaneous T Cell Lymphoma

About this section

Pathways related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KIR2DL1, KIR2DL3
29.6IL2RA, IL7
3
Show member pathways
9.6IL7, IL2RA
4
Show member pathways
Immune response CD16 signaling in NK cells60
9.4IFNA2, KIR2DL1, KIR2DL3
59.3IL7, IL2RA, IFNA2
6
Show member pathways
9.3IL7, IL2RA, IFNA2
7
Show member pathways
Type III interferon signaling37
9.3IL2RA, IL7, IFNA2
8
Show member pathways
9.0IL2RA, IFNA2, KIR2DL3, KIR2DL1
9
Show member pathways
8.8IL7, IL2RA, CCL17
10
Show member pathways
8.8CCL17, IL2RA, IL7
11
Show member pathways
8.5IL7, IL2RA, IFNA2, CCL17
12
Show member pathways
8.5CCL17, IFNA2, IL2RA, IL7

Compounds for genes affiliated with Cutaneous T Cell Lymphoma

About this section

Compounds related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1mizoribine4410.2IL2RA, IFNA2
2pentostatin44 61 28 1113.2IFNA2, IL2RA
3hydroxychloroquine44 1111.1IL2RA, IFNA2
4megestrol acetate4410.1IL2RA, IFNA2
5levamisole44 1111.1IFNA2, IL2RA
6lamivudine44 50 1112.1IL2RA, IFNA2
7con a4410.1IFNA2, IL2RA
8diethyl dithiocarbamate4410.1IL2RA, IFNA2
92,5-oligoadenylate4410.1IL2RA, IFNA2
10infliximab44 50 1112.0IFNA2, IL2RA
11erythromycin44 2 50 1113.0IL2RA, IFNA2
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.0IL7, IFNA2
13c-d4t4410.0IL7, IL2RA
14ifn-alpha4410.0IFNA2, IL2RA
15basiliximab44 1111.0IL2RA, IL7
16betacarotene4410.0IL2RA, IFNA2
17okt34410.0IL7, IL2RA
18neopterin4410.0IL2RA, IFNA2
19rituximab44 50 1111.9IFNA2, IL2RA
20bleomycin44 1110.9IFNA2, IL2RA
21thalidomide44 50 61 1112.8IL2RA, IFNA2
22vitamin-e449.7IL2RA, IFNA2
23vincristine44 50 1111.7IL2RA, IFNA2
24cyclophosphamide44 50 1111.7IFNA2, IL2RA, IL7
25azathioprine44 2 50 1112.6IFNA2, IL2RA
26histamine44 28 2411.6IFNA2, IL2RA, IL7
27doxorubicin44 50 1111.6IFNA2, IL2RA, IL7
28neomycin449.5IL7, ANG
29thymidine44 2410.5IFNA2, IL2RA, IL7
30ccl444 2810.5IL7, CCL17
31alpha tocopherol449.4IL2RA, IFNA2
32allergens449.4IL7, CCL17
33il 10449.2IL7, IL2RA, CCL17
34tacrolimus44 50 1111.2IL7, IL2RA, CCL17
35rantes449.2CCL17, IL2RA, IL7
36cyclosporin a44 28 6111.1IL7, IL2RA, CCL17
37vegf449.0IL7, IL2RA, IFNA2, ANG
38tyrosine448.4ANG, IFNA2, IL2RA, IL7, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

About this section

Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3IL7, IFNA2, CCL17, ANG

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.8KIR2DL1, KIR2DL3
2positive regulation of T cell differentiationGO:0455829.5IL2RA, IL7
3cell-cell signalingGO:0072678.6CCL17, IFNA2, IL7
4immune responseGO:0069558.5KIR2DL1, KIR2DL3, IL2RA, CCL17

Products for genes affiliated with Cutaneous T Cell Lymphoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Cutaneous T Cell Lymphoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet