CTCL
MCID: CTN015
MIFTS: 44

Cutaneous T Cell Lymphoma (CTCL) malady

Immune diseases category

Summaries for Cutaneous T Cell Lymphoma

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8Disease Ontology, 42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards: Cutaneous T Cell Lymphoma, also known as lymphoma, t-cell, cutaneous, is related to mycosis fungoides and dermatitis. An important gene associated with Cutaneous T Cell Lymphoma is ZNF638 (zinc finger protein 638). The drugs bexarotene and denileukin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node.

Disease Ontology:8 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

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8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

cutaneous t cell lymphoma 8 10
lymphoma, t-cell, cutaneous 60
cutaneous t-cell lymphoma 42
lymphoma t-cell cutaneous 44
ctcl 42


External Ids:

Disease Ontology8 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Clinical Features for Cutaneous T Cell Lymphoma

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Drugs & Therapeutics for Cutaneous T Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cutaneous T Cell Lymphoma

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Anatomical Context for Cutaneous T Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Cutaneous T Cell Lymphoma:

32
T cells, Skin, Lymph node, B cells, Bone, Monocytes, Colon, Testis, Bone marrow, Endothelial, Testes, Heart, Thymus, Lung, Liver, Nk cells

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

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Publications for Cutaneous T Cell Lymphoma

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50PubMed
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Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 811)
idTitleAuthorsYear
1
Primary cutaneous follicular helper T-cell lymphoma treated with allogeneic bone marrow transplantation: immunohistochemical comparison with angioimmunoblastic T-cell lymphoma. (23756572)
2014
2
Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma. (23949004)
2013
3
Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. (23801634)
2013
4
Errors in Byline and Text in: Primary Cutaneous Follicular Helper T-cell Lymphoma: A New Subtype of Cutaneous T-cell Lymphoma Reported in a Series of 5 Cases. (23752735)
2012
5
Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma. (21989349)
2012
6
Extracorporeal photopheresis, a therapeutic option for cutaneous T-cell lymphoma and immunological diseases: state of the art. (22587646)
2012
7
Leukaemic variant of cutaneous T-cell lymphoma with CD3- CD4+ phenotype. (22420389)
2012
8
Interleukin-17 expression in neutrophils and Th17 cells in cutaneous T-cell lymphoma associated with neutrophilic infiltrate of the skin. (21936854)
2012
9
Romidepsin in the treatment of cutaneous T-cell lymphoma. (22287862)
2011
10
Composite primary cutaneous peripheral T-cell lymphoma and Epstein-Barr virus-positive large B-cell lymphoma. (21699457)
2011
11
Structural alterations of the FAS gene in cutaneous T-cell lymphoma (CTCL). (21036138)
2011
12
Primary cutaneous, composite, Epstein-Barr virus-associated, diffuse large B-cell lymphoma and peripheral T-cell lymphoma. (21946762)
2011
13
Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma. (21741937)
2011
14
Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage. (20625418)
2010
15
Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. (20505746)
2010
16
Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. (20133897)
2010
17
Serum interleukin-27 levels in patients with cutaneous T-cell lymphoma. (19874357)
2010
18
A novel xenograft model of cutaneous T-cell lymphoma. (20629733)
2010
19
Outsmarting cutaneous T-cell lymphoma cells by decoding the language they speak: focusing past and present insights on future prospects. (20826398)
2010
20
Indolent CD8+ lymphoid proliferation of the ear: a phenotypic variant of the small-medium pleomorphic cutaneous T-cell lymphoma? (19602068)
2010
21
Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. (19067706)
2009
22
Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. (19195975)
2009
23
Cutaneous peripheral T-cell lymphoma associated with a proliferation of B cells. (19461087)
2009
24
Mycosis fungoides and CD30+ cutaneous T-cell lymphoma simulating pyoderma gangrenosum in a patient with ulcerative colitis. (21886726)
2009
25
Increased malignancy risk in the cutaneous T-cell lymphoma patient population. (18501103)
2008
26
Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. (18569641)
2008
27
Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy. (18601524)
2008
28
Erythrodermic cutaneous T cell lymphoma with hypereosinophilic syndrome: Treatment with interferon alfa and extracorporeal photopheresis. (17988344)
2007
29
Maintenance therapy in cutaneous T-cell lymphoma: who, when, what? (17707638)
2007
30
Biologic correlates of response and survival in patients with cutaneous T-cell lymphoma treated with denileukin diftitox. (17229335)
2006
31
Extracorporeal photochemotherapy in patients with cutaneous T-cell lymphoma: is clinical response predictable? (16987266)
2006
32
Transimmunization for cutaneous T cell lymphoma: a Phase I study. (16966259)
2006
33
Activation of neutrophils in cutaneous T-cell lymphoma. (16322281)
2005
34
Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. (15897551)
2005
35
A case of poikiloderma vasculare atrophicans, a rare variant of cutaneous T-cell lymphoma, responding to extracorporeal photopheresis. (15793532)
2005
36
Fatal CD8+ epidermotropic cytotoxic primary cutaneous T-cell lymphoma with multiorgan involvement. (16205076)
2005
37
Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2. (14592815)
2004
38
Atopic dermatitis-like non-erythrodermic leukemic variant of CD3(-/+dim) CD4(+) cutaneous T-cell lymphoma preceded by cutaneous papular xanthomatosis. (15160924)
2004
39
Cutaneous T-cell lymphoma in a 21-year-old male with Wolf-Hirschhorn syndrome. (15103723)
2004
40
CD26 expression on cutaneous infiltrates from patients with cutaneous T-cell lymphoma (CTCL) CD26 in cutaneous T-cell lymphoma patients. (12675243)
2003
41
Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma. (12207607)
2002
42
Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia. (10861816)
2000
43
Treatment of cutaneous T-cell lymphoma from a dermatologist's perspective. (11707858)
2000
44
Epidermal interferon-gamma inducible protein-10 (IP-10) and monokine induced by gamma-interferon (Mig) but not IL-8 mRNA expression is associated with epidermotropism in cutaneous T cell lymphomas. (9699721)
1998
45
Interferon-inducible protein 10 as a possible factor in the pathogenesis of cutaneous T-cell lymphomas. (9815669)
1997
46
Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma. (8409516)
1993
47
Interferon treatment of cutaneous T-cell lymphoma. (7690332)
1993
48
Specific cutaneous lesions in a CD8+ peripheral T-cell lymphoma. (1459758)
1992
49
Phase I trial of H65-RTA immunoconjugate in patients with cutaneous T-cell lymphoma. (1878584)
1991
50
Cutaneous T cell lymphoma with suppressor/cytotoxic (CD8) phenotype: identification of rapidly progressive and chronic subtypes. (2138636)
1990

Genetic Variations for Cutaneous T Cell Lymphoma

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Expression for genes affiliated with Cutaneous T Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cutaneous T Cell Lymphoma

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Pathways for genes affiliated with Cutaneous T Cell Lymphoma

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Compounds for genes affiliated with Cutaneous T Cell Lymphoma

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GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

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16Gene Ontology
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Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular_componentGO:00557510.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biological_processGO:00815010.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Products for genes affiliated with Cutaneous T Cell Lymphoma

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Sources for Cutaneous T Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet