CTCL
MCID: CTN015
MIFTS: 37

Cutaneous T Cell Lymphoma (CTCL) malady

Summaries for Cutaneous T Cell Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards: Cutaneous T Cell Lymphoma, also known as lymphoma, t-cell, cutaneous, is related to mycosis fungoides and lymphomatoid papulosis. An important gene associated with Cutaneous T Cell Lymphoma is ZNF638 (zinc finger protein 638). The drugs bexarotene and denileukin have been mentioned in the context of this disorder.

Disease Ontology:8 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

Sources:
8Disease Ontology, 10DISEASES, 43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

cutaneous t cell lymphoma 8 10
lymphoma, t-cell, cutaneous 61
cutaneous t-cell lymphoma 43
lymphoma t-cell cutaneous 45
ctcl 43


External Ids:

Disease Ontology8 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cutaneous T Cell Lymphoma family:

primary cutaneous gamma/delta-positive t-cell lymphoma

Diseases related to Cutaneous T Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides31.5CCR10
2lymphomatoid papulosis10.7
3b-cell lymphomas10.6
4follicular lymphoma10.6
5atopic dermatitis10.6
6parapsoriasis10.5
7adult lymphoma10.5
8pityriasis lichenoides10.5
9graft versus host disease10.5
10follicular mucinosis10.5
11sezary's disease10.5
12pityriasis lichenoides chronica10.4
13chronic actinic dermatitis10.4
14central nervous system lymphoma10.3
15spongiotic dermatitis10.3
16bone lymphoma10.3
17pyoderma gangrenosum10.3
18capillary leak syndrome10.3
19porokeratosis10.3
20t-cell leukemia10.3
21vasculitis10.3
22xanthomatosis10.3
23chronic graft versus host disease10.3
24eosinophilic fasciitis10.3
25hydroa vacciniforme10.3
26leukemia/lymphoma, t-cell10.3
27hematopoietic stem cell transplantation10.3
28genital herpes10.2
29bullous pemphigoid10.2
30colon lymphoma10.2
31tropical spastic paraparesis10.2
32hepatitis c10.2
33thymus lymphoma10.2
34diphtheria10.2
35cutaneous diphtheria10.2
36wolf-hirschhorn syndrome10.2
37west syndrome10.2
38mu chain disease10.2
39heart lymphoma10.2
40chronic eosinophilic pneumonia10.2
41lung lymphoma10.2
42protein s deficiency10.2
43ulcerative colitis10.2
44measles10.2
45hypercalcemia10.2
46cerebral lymphoma10.2
47adult syndrome10.2
48composite lymphoma10.2
49pediatric lymphoma10.2
50verrucous carcinoma10.2

Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Clinical Features for Cutaneous T Cell Lymphoma

Drugs & Therapeutics for Cutaneous T Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cutaneous T Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Cutaneous T Cell Lymphoma

Search NIH Clinical Center for Cutaneous T Cell Lymphoma

Search CenterWatch for Cutaneous T Cell Lymphoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cutaneous T Cell Lymphoma

Anatomical Context for Cutaneous T Cell Lymphoma

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Cutaneous T Cell Lymphoma

Sources:
51PubMed
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Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 380)
idTitleAuthorsYear
1
Novel therapies for cutaneous T-cell lymphoma: what does the future hold? (24397291)
2014
2
Treatment of indolent primary cutaneous B-cell lymphomas with subcutaneous interferon-alfa. (24433874)
2014
3
miR-223 Regulates Cell Growth and Targets Proto-Oncogenes in Mycosis Fungoides/Cutaneous T-Cell Lymphoma. (24304814)
2013
4
Primary cutaneous B-cell lymphomas: part II. Therapy and future directions. (23957985)
2013
5
Phase II study of gemcitabine and bexarotene (GEMBEX) in the treatment of cutaneous T-cell lymphoma. (24136145)
2013
6
Allogeneic stem cell transplantation for advanced primary cutaneous T-cell lymphoma: a systematic review. (22819279)
2013
7
Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature. (23837676)
2013
8
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Intralesional Methotrexate Therapy. (24002114)
2013
9
Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma. (24307695)
2013
10
Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma. (22459529)
2012
11
Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the I+/I^ Type with Bexarotene. (22548037)
2012
12
Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma. (22258991)
2012
13
Novel therapeutic agents for cutaneous T-Cell lymphoma. (22594538)
2012
14
FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type. (21154235)
2011
15
Co-infection of human herpesvirus-6 and human herpesvirus-8 in primary cutaneous diffuse large B-cell lymphoma, leg type. (21517824)
2011
16
Primary cutaneous CD30 positive anaplastic large cell lymphoma--report of a case treated with bexarotene. (21764128)
2011
17
A case of chronic inflammatory demyelinating polyneuropathy associated with immune-mediated thrombocytopenia and cutaneous T-cell lymphoma. (21704451)
2011
18
Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). (21883142)
2011
19
Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma. (20629661)
2010
20
Pediatric primary cutaneous marginal zone B-cell lymphoma treated with intralesional rituximab. (20542839)
2010
21
A cutaneous T-cell lymphoma EORTC trials platform. (20826406)
2010
22
Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma. (20133897)
2010
23
Potent topical steroids are one of the treatments for cutaneous T-cell lymphoma. (20621338)
2010
24
Before and after treatment 18F-FDG PET/CT images in a patient with cutaneous T-cell lymphoma. (20658231)
2010
25
Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma. (20212249)
2010
26
When dead cells tell tales-cutaneous involvement by precursor T-cell acute lymphoblastic lymphoma with an uncommon phenotype. (20010405)
2010
27
Primary cutaneous diffuse large B-cell lymphoma, leg type, with features simulating POEMS syndrome. (19558504)
2010
28
Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task. (19548068)
2009
29
Primary cutaneous diffuse large B-cell lymphoma, leg type in an elderly man with human immunodeficiency virus encephalopathy. (19734989)
2009
30
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
31
Primary cutaneous anaplastic large cell lymphoma successfully treated with local thermotherapy using pocket hand warmers. (19120772)
2008
32
Cutaneous T cell lymphoma: translating immunobiology into therapeutic opportunities. (18833050)
2008
33
Denileukin diftitox for the treatment of cutaneous T-cell lymphoma. (19707452)
2008
34
Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy. (18601524)
2008
35
Successful treatment for recurrence of primary cutaneous anaplastic large-cell lymphoma in elderly patient with etoposide, mitoxantrone, cyclophosphamide, vincristine, prednisolone and bleomycin (VNCOP-B) therapy. (17683387)
2007
36
Results of a phase II trial of oral bexarotene (Targretin) combined with interferon alfa-2b (Intron-A) for patients with cutaneous T-cell lymphoma. (17366595)
2007
37
Advances in the treatment of primary cutaneous T-cell lymphoma. (17673888)
2007
38
Primary cutaneous marginal zone B-cell lymphoma of MALT type in a child. (17163787)
2006
39
Fusariosis occurring in an ulcerated cutaneous CD8+ T cell lymphoma tumor. (16709499)
2006
40
Severe diarrhoea during Campath-1H treatment for refractory cutaneous T-cell lymphoma. (16821018)
2006
41
cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (12839582)
2003
42
Topical and systemic retinoid therapy for cutaneous T-cell lymphoma. (14710892)
2003
43
Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. (12006543)
2002
44
Treatment of cutaneous T-cell lymphoma with combined immunomodulatory therapy: a 14-year experience at a single institution. (12164743)
2002
45
The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation. (11407974)
2001
46
Lymphoma-type adult T-cell leukaemia-lymphoma with a bulky cutaneous tumour showing multiple human T-lymphotropic virus-1 DNA integration. (11422051)
2001
47
Cutaneous T-cell lymphoma of the mycosis fungoides type in the area of the eyelid and lacrimal ducts]. (9206737)
1997
48
A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma. (8668164)
1996
49
Cutaneous T-cell lymphoma, tropical spastic paraparesis, cerebral vasculitis, and protein S deficiency in a patient with HTLV-I. (8865796)
1996
50
Lymphomatoid papulosis terminating as cutaneous T cell lymphoma (mycosis fungoides). (6643771)
1983

Genetic Variations for Cutaneous T Cell Lymphoma

Expression for genes affiliated with Cutaneous T Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cutaneous T Cell Lymphoma

Search GEO for disease gene expression data for Cutaneous T Cell Lymphoma.

Pathways for genes affiliated with Cutaneous T Cell Lymphoma

Compounds for genes affiliated with Cutaneous T Cell Lymphoma

GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

Sources:
16Gene Ontology
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Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular_componentGO:00557510.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biological_processGO:00815010.7CTAGE6, CTAGE1, CTAGE4, CTAGE3P

Products for genes affiliated with Cutaneous T Cell Lymphoma

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Sources for Cutaneous T Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet