MCID: CTN015
MIFTS: 51

Cutaneous T Cell Lymphoma malady

Rare diseases, Immune diseases, Skin diseases, Blood diseases, Cancer diseases categories

Summaries for Cutaneous T Cell Lymphoma

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NIH Rare Diseases:43 Cutaneous t-cell lymphomas (ctcls) are a group of disorders characterized by an abnormal accumulation of cancerous t-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. ctcls belong to a larger group of disorders known asnon-hodgkin's lymphomas. the most common types are mycosis fungoides and sézary syndrome. in some cases, cancerous t-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. the specific signs and symptoms vary from person to person. the exact cause of these conditions is unknown. last updated: 9/27/2011

MalaCards based summary: Cutaneous T Cell Lymphoma, also known as primary cutaneous t-cell lymphoma, is related to mycosis fungoides and sezary's disease. An important gene associated with Cutaneous T Cell Lymphoma is IFNA2 (interferon, alpha 2), and among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Hematopoietic cell lineage. The drugs bexarotene and denileukin and the compounds mizoribine and pentostatin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and lymph node.

Disease Ontology:10 A non-hodgkin's lymphoma that is caused by a mutation of t cells.

Aliases & Classifications for Cutaneous T Cell Lymphoma

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Cutaneous T Cell Lymphoma, Aliases & Descriptions:

Name: Cutaneous T Cell Lymphoma 10 12
Primary Cutaneous T-Cell Lymphoma 43
Lymphoma, T-Cell, Cutaneous 62
 
Cutaneous T-Cell Lymphoma 43
Lymphoma T-Cell Cutaneous 45
Ctcl 43


Classifications:



External Ids:

Disease Ontology10 DOID:0060061

Related Diseases for Cutaneous T Cell Lymphoma

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Diseases in the Cutaneous T Cell Lymphoma family:

Primary Cutaneous Gamma/delta-Positive T-Cell Lymphoma

Diseases related to Cutaneous T Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides31.5IFNA2, IL2RA, IL7, CCL17, PLS3
2sezary's disease30.7IL7, IL2RA, PLS3, IFNA2
3chronic lymphocytic leukemia30.5IL2RA, IL7
4hodgkin lymphoma30.5IL2RA, CCL17, IL7
5psoriasis30.5IL2RA, IL7, KIR2DL3, CCL17
6bullous pemphigoid30.3IL7, CCL17
7hepatitis c30.3IL7, IFNA2, KIR2DL3
8ulcerative colitis30.3IL2RA, CCL17, IL7
9thrombocytopenia30.3IFNA2, IL7
10rheumatoid arthritis30.2IL2RA, IL7, KIR2DL1, ANG
11melanoma30.0KIR2DL1, IL7, ANG, IFNA2
12dermatitis10.8
13lymphomatoid papulosis10.7
14leukemia10.6
15atopic dermatitis10.5
16parapsoriasis10.5
17t-cell leukemia10.5
18pityriasis lichenoides10.5
19adult t-cell leukemia10.5
20hydroa vacciniforme10.5
21follicular mucinosis10.4
22pneumonia10.4
23chronic graft versus host disease10.4
24pityriasis lichenoides chronica10.4
25chronic actinic dermatitis10.4
26b-cell lymphomas10.3
27hematopoietic stem cell transplantation10.3
28peripheral t-cell lymphoma10.3
29pyoderma gangrenosum10.3
30capillary leak syndrome10.3
31dermatitis herpetiformis10.3
32fasciitis10.3
33pyoderma10.3
34vasculitis10.3
35xanthomatosis10.3
36eosinophilic fasciitis10.3
37wolf-hirschhorn syndrome10.2
38aspergillosis10.2
39epidermodysplasia verruciformis10.2
40lung cancer10.2
41alopecia universalis10.2
42atopy10.2
43alopecia10.2
44arthritis10.2
45chronic inflammatory demyelinating polyneuropathy10.2
46congestive heart failure10.2
47hepatitis10.2
48skin disease10.2
49tropical spastic paraparesis10.2
50chronic eosinophilic pneumonia10.2

Graphical network of the top 20 diseases related to Cutaneous T Cell Lymphoma:



Diseases related to cutaneous t cell lymphoma

Symptoms for Cutaneous T Cell Lymphoma

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Drugs & Therapeutics for Cutaneous T Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Cutaneous T Cell Lymphoma

Search NIH Clinical Center for Cutaneous T Cell Lymphoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cutaneous T Cell Lymphoma

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Anatomical Context for Cutaneous T Cell Lymphoma

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MalaCards organs/tissues related to Cutaneous T Cell Lymphoma:

33
T cells, Skin, Lymph node, B cells, Bone, Neutrophil, Bone marrow, Testis, Monocytes, Heart, Colon, Liver, Lung, Testes, Nk cells, Endothelial

Animal Models for Cutaneous T Cell Lymphoma or affiliated genes

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Publications for Cutaneous T Cell Lymphoma

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Articles related to Cutaneous T Cell Lymphoma:

(show top 50)    (show all 740)
idTitleAuthorsYear
1
Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data. (25891346)
2015
2
Resimmune-an anti-CD3I/ recombinant immunotoxin induces durable remissions in cutaneous T cell lymphoma patients. (25795722)
2015
3
Cutaneous T-cell lymphoma with nasal necrosis. (25798408)
2015
4
Phase II evaluation of VDC-1101 in canine cutaneous T-cell lymphoma. (25274443)
2014
5
Novel therapies for cutaneous T-cell lymphoma: what does the future hold? (24397291)
2014
6
Romidepsin for cutaneous T-cell lymphoma. (24295412)
2013
7
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
8
Expression of miR-155 and miR-126 in situ in cutaneous T-cell lymphoma. (24033365)
2013
9
Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum. (23331699)
2013
10
Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma. (22948508)
2013
11
Comparison of pegylated interferon I+-2b plus psoralen PUVA versus standard interferon I+-2a plus PUVA in patients with cutaneous T-cell lymphoma. (22168776)
2012
12
Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma. (22459529)
2012
13
Integrated positron-emission tomography and computed tomography manifestations of cutaneous T-cell lymphoma. (23247490)
2012
14
Low herpesvirus entry mediator (HVEM) expression on dermal fibroblasts contributes to a Th2-dominant microenvironment in advanced cutaneous T-cell lymphoma. (22297640)
2012
15
Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. (22457602)
2012
16
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. (22383798)
2012
17
Photopheresis in the treatment of cutaneous T-cell lymphoma: current status. (22157241)
2012
18
The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T-cell lymphoma patients. (22367792)
2012
19
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. (22048239)
2011
20
Romidepsin in the treatment of cutaneous T-cell lymphoma. (22287862)
2011
21
The role of cytokine signaling in the pathogenesis of cutaneous T-cell lymphoma. (22236880)
2011
22
Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomas. (21872828)
2011
23
Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage. (20625418)
2010
24
Posttransplant cutaneous T-cell lymphoma: case reports and review of the association of calcineurin inhibitor use with posttransplant lymphoproliferative disease risk. (20479299)
2010
25
Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. (20888065)
2010
26
Primary cutaneous T-cell lymphoma following organ transplantation in a 16-year-old boy. (19250431)
2009
27
Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: clinicopathological analysis of 27 patients. (19018763)
2009
28
Extracorporeal methoxsalen: new drug. Cutaneous T cell lymphoma: for rare patients, but better assessment needed. (19388212)
2009
29
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. (19258503)
2009
30
SAczary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. (18033314)
2008
31
U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. (18241274)
2008
32
Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents. (18245554)
2008
33
T-cell receptor-gamma gene analysis in evolving to advancing cutaneous T-cell lymphoma. (17680965)
2007
34
Cutaneous T-cell lymphoma. (16720231)
2006
35
Treatment of cutaneous T-cell lymphoma with retinoids. (17014481)
2006
36
Future perspectives in the treatment of cutaneous T-cell lymphoma (CTCL). (16516674)
2006
37
Activation of neutrophils in cutaneous T-cell lymphoma. (16322281)
2005
38
CCR10 is expressed in cutaneous T-cell lymphoma. (15700309)
2005
39
Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. (15514008)
2005
40
Serological immunomarkers in cutaneous T cell lymphoma. (15539892)
2004
41
T cell receptor gamma-chain gene polymerase chain reaction to diagnose central nervous system involvement by cutaneous T cell lymphoma. (11986404)
2002
42
Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. (11675351)
2001
43
Functional inhibitory receptors expressed by a cutaneous T cell lymphoma-specific cytolytic clonal T cell population. (11121132)
2000
44
Activity of pentostatin (Nipent) in cutaneous T-cell lymphoma: single-agent and combination studies. (10877054)
2000
45
Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells. (9864169)
1999
46
Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. (9176388)
1997
47
A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma. (8668164)
1996
48
Interferon-inducible protein-10 and the pathogenesis of cutaneous T-cell lymphomas. (9049966)
1996
49
Chronic actinic dermatitis. An immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. (7802165)
1994
50
Interferon alpha and etretinate combination treatment of cutaneous T-cell lymphoma. (2258637)
1990

Variations for Cutaneous T Cell Lymphoma

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Cosmic variations for Cutaneous T Cell Lymphoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1532KRAShaematopoietic and lymphoid tissue,skin,lymphoid neoplasm,cutaneous T cell lymphoma1

Expression for genes affiliated with Cutaneous T Cell Lymphoma

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Search GEO for disease gene expression data for Cutaneous T Cell Lymphoma.

Pathways for genes affiliated with Cutaneous T Cell Lymphoma

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Pathways related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KIR2DL1, KIR2DL3
29.6IL2RA, IL7
3
Show member pathways
9.6IL7, IL2RA
4
Show member pathways
Immune response CD16 signaling in NK cells60
9.4KIR2DL1, KIR2DL3, IFNA2
59.3IL7, IL2RA, IFNA2
6
Show member pathways
9.3IFNA2, IL2RA, IL7
7
Show member pathways
Type III interferon signaling38
9.3IL7, IL2RA, IFNA2
8
Show member pathways
9.0KIR2DL1, KIR2DL3, IL2RA, IFNA2
9
Show member pathways
8.8CCL17, IL2RA, IL7
10
Show member pathways
8.8CCL17, IL2RA, IL7
11
Show member pathways
8.5CCL17, IFNA2, IL2RA, IL7
12
Show member pathways
8.5CCL17, IFNA2, IL2RA, IL7

Compounds for genes affiliated with Cutaneous T Cell Lymphoma

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Compounds related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1mizoribine4510.2IL2RA, IFNA2
2pentostatin45 61 30 1313.2IFNA2, IL2RA
3hydroxychloroquine45 1311.1IL2RA, IFNA2
4megestrol acetate4510.1IL2RA, IFNA2
5levamisole45 1311.1IFNA2, IL2RA
6lamivudine45 51 1312.1IL2RA, IFNA2
7con a4510.1IFNA2, IL2RA
8diethyl dithiocarbamate4510.1IL2RA, IFNA2
92,5-oligoadenylate4510.1IL2RA, IFNA2
10infliximab45 51 1312.0IFNA2, IL2RA
11erythromycin45 3 51 1313.0IL2RA, IFNA2
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4510.0IL7, IFNA2
13c-d4t4510.0IL7, IL2RA
14ifn-alpha4510.0IFNA2, IL2RA
15basiliximab45 1311.0IL2RA, IL7
16betacarotene4510.0IL2RA, IFNA2
17okt34510.0IL7, IL2RA
18neopterin4510.0IL2RA, IFNA2
19rituximab45 51 1311.9IFNA2, IL2RA
20bleomycin45 1310.9IFNA2, IL2RA
21thalidomide45 51 61 1312.8IL2RA, IFNA2
22vitamin-e459.7IL2RA, IFNA2
23vincristine45 51 1311.7IL2RA, IFNA2
24cyclophosphamide45 51 1311.7IFNA2, IL2RA, IL7
25azathioprine45 3 51 1312.6IFNA2, IL2RA
26histamine45 30 2611.6IFNA2, IL2RA, IL7
27doxorubicin45 51 1311.6IFNA2, IL2RA, IL7
28neomycin459.5IL7, ANG
29thymidine45 2610.5IFNA2, IL2RA, IL7
30ccl445 3010.5IL7, CCL17
31alpha tocopherol459.4IL2RA, IFNA2
32allergens459.4IL7, CCL17
33il 10459.2IL7, IL2RA, CCL17
34tacrolimus45 51 1311.2IL7, IL2RA, CCL17
35rantes459.2CCL17, IL2RA, IL7
36cyclosporin a45 30 6111.1IL7, IL2RA, CCL17
37vegf459.0IL7, IL2RA, IFNA2, ANG
38tyrosine458.4ANG, IFNA2, IL2RA, IL7, KIR2DL3, KIR2DL1

GO Terms for genes affiliated with Cutaneous T Cell Lymphoma

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Cellular components related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3IL7, IFNA2, CCL17, ANG

Biological processes related to Cutaneous T Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:00507769.8KIR2DL1, KIR2DL3
2positive regulation of T cell differentiationGO:00455829.5IL2RA, IL7
3cell-cell signalingGO:00072678.6IL7, IFNA2, CCL17
4immune responseGO:00069558.5KIR2DL1, KIR2DL3, IL2RA, CCL17

Products for genes affiliated with Cutaneous T Cell Lymphoma

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Sources for Cutaneous T Cell Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet