MCID: CTS001
MIFTS: 58

Cutis Laxa malady

Categories: Genetic diseases, Rare diseases, Skin diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Fetal diseases, Mental diseases, Bone diseases, Gastrointestinal diseases, Nephrological diseases, Cardiovascular diseases

Aliases & Classifications for Cutis Laxa

About this section

Summaries for Cutis Laxa

About this section
NIH Rare Diseases:48 Cutis laxa is a connective tissue disorder characterized by skin that is sagging and not stretchy. the skin often hangs in loose folds, causing the face and other parts of the body to have a droopy appearance. cutis laxa can also affect connective tissue in other parts of the body, including the heart, blood vessels, joints, intestines, and lungs. depending on which organs and tissues are affected, the signs and symptoms can range from mild to life-threatening. it may be acquired or inherited. the different forms of inherited cutis laxa are distinguished by their pattern of inheritance: autosomal dominant, autosomal recessive, or x-linked. in general, the autosomal recessive forms tend to be more severe than the autosomal dominant form. the x-linked form of cutis laxa is often called occipital horn syndrome. last updated: 4/1/2016

MalaCards based summary: Cutis Laxa, also known as generalized elastolysis, is related to cutis laxa, autosomal recessive, type iia and cutis laxa, autosomal recessive, type ia, and has symptoms including pruritus, pruritus and recurrent urinary tract infections. An important gene associated with Cutis Laxa is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways are Arginine and proline metabolism and Amino acid synthesis and interconversion (transamination). Affiliated tissues include skin, heart and lung, and related mouse phenotype integument.

Genetics Home Reference:25 Cutis laxa is a disorder of connective tissue, which is the tissue that forms the body's supportive framework. Connective tissue provides structure and strength to the muscles, joints, organs, and skin.

Disease Ontology:11 A skin disease characterized by skin that is loose, hanging, wrinkled and lacking in elasticity; it can also affect connective tissue in other parts of the body, including the heart, blood vessels, joints, intestines and lungs.

Wikipedia:71 Cutis laxa (also known as chalazoderma, dermatochalasia, dermatolysis, dermatomegaly, generalized... more...

Related Diseases for Cutis Laxa

About this section

Diseases in the Cutis Laxa family:

Cutis Laxa, Ad Cutis Laxa, Autosomal Recessive, Type Iiia
Cutis Laxa, Autosomal Dominant 3 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iia Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Iib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Recessive, Type Ic
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Cutis Laxa, Autosomal Dominant Cutis Laxa, Autosomal Recessive Type 1
Aldh18a1-Related Cutis Laxa Eln-Related Cutis Laxa
Pycr1-Related Cutis Laxa Acquired Cutis Laxa

Diseases related to Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1cutis laxa, autosomal recessive, type iia12.5
2cutis laxa, autosomal recessive, type ia12.4
3cutis laxa, autosomal recessive, type iib12.4
4cutis laxa, autosomal recessive, type ic12.4
5cutis laxa, autosomal recessive, type iiib12.4
6cutis laxa, ad12.4
7cutis laxa, autosomal recessive, type iiia12.4
8cutis laxa, autosomal recessive, type ib12.4
9cutis laxa, autosomal dominant 212.3
10atp6v0a2-related cutis laxa12.3
11cutis laxa, autosomal dominant 312.3
12macrocephaly, alopecia, cutis laxa, and scoliosis12.2
13efemp2-related cutis laxa12.2
14cutis laxa, autosomal dominant12.2
15acquired cutis laxa12.2
16ltbp4-related cutis laxa12.1
17cutis laxa, autosomal recessive type 112.1
18fbln5-related cutis laxa12.1
19aldh18a1-related cutis laxa12.1
20pycr1-related cutis laxa12.0
21cutis laxa, neonatal, with marfanoid phenotype12.0
22dysmorphism cleft palate loose skin12.0
23de barsy syndrome11.9
24cutis laxa osteoporosis11.9
25eln-related cutis laxa11.9
26occipital horn syndrome11.8
27wrinkly skin syndrome11.3
28menkes disease11.3
29scarf syndrome11.3
30familial amyloidosis, finnish type11.1
31ehlers-danlos syndrome, type viic11.0
32transaldolase deficiency11.0
33mounier-kuhn syndrome11.0
34cantu sanchez-corona hernandez syndrome10.9
35trichorhinophalangeal syndrome, type ii10.7
36multiple myeloma10.3
37cystic hygroma lethal cleft palate10.3EFEMP2, FBLN5
38acute pandysautonomia10.3ELN, FBLN5
39macular degeneration, age-related, 310.3EFEMP2, FBLN5
40antley-bixler syndrome with genital anomalies and disordered steroidogenesis10.3ELN, FBLN5
41familial paroxysmal kinesigenic dyskinesia10.3ELN, FBLN5
42taylor's syndrome10.2EFEMP2, FBLN5
43seminal vesicle acute gonorrhea10.2ALDH18A1, ELN
44pseudoxanthoma elasticum10.2
45amyloidosis10.2
46arterial occlusive disease, progressive, with hypertension, heart defects, bone fragility, and brachysyndactyly10.1ABCC6, ELN
47graves disease 210.1EFEMP2, LTBP4
48pulmonary emphysema10.1
49ehlers-danlos syndrome10.1
50du pan syndrome10.1FBLN5, RIN2

Graphical network of the top 20 diseases related to Cutis Laxa:



Diseases related to cutis laxa

Symptoms & Phenotypes for Cutis Laxa

About this section

Human phenotypes related to Cutis Laxa:

 64 (show all 68)
id Description HPO Frequency HPO Source Accession
1 recurrent urinary tract infections64 HP:0000010
2 inguinal hernia64 HP:0000023
3 hydroureter64 HP:0000072
4 vesicoureteral reflux64 HP:0000076
5 narrow mouth64 HP:0000160
6 abnormality of the palate64 HP:0000174
7 hydrocephalus64 HP:0000238
8 large fontanelles64 HP:0000239
9 turricephaly64 HP:0000262
10 epicanthus64 HP:0000286
11 hypertelorism64 HP:0000316
12 long philtrum64 HP:0000343
13 micrognathia64 HP:0000347
14 low-set ears64 HP:0000369
15 depressed nasal ridge64 HP:0000457
16 anteverted nares64 HP:0000463
17 short neck64 HP:0000470
18 thickened nuchal skin fold64 HP:0000474
19 downslanted palpebral fissures64 HP:0000494
20 telecanthus64 HP:0000506
21 ptosis64 HP:0000508
22 carious teeth64 HP:0000670
23 pectus excavatum64 HP:0000767
24 pectus carinatum64 HP:0000768
25 hypothyroidism64 HP:0000821
26 eczema64 HP:0000964
27 urticaria64 HP:0001025
28 macular coloboma64 HP:0001116
29 muscular hypotonia64 HP:0001252
30 global developmental delay64 HP:0001263
31 muscle weakness64 HP:0001324
32 plagiocephaly64 HP:0001357
33 craniosynostosis64 HP:0001363
34 joint dislocation64 HP:0001373
35 intrauterine growth retardation64 HP:0001511
36 redundant skin64 HP:0001582
37 ventricular septal defect64 HP:0001629
38 atrial septal defect64 HP:0001631
39 congestive heart failure64 HP:0001635
40 patent ductus arteriosus64 HP:0001643
41 aortic valve stenosis64 HP:0001650
42 abnormality of metabolism/homeostasis64 HP:0001939
43 leukocytosis64 HP:0001974
44 malabsorption64 HP:0002024
45 respiratory insufficiency64 HP:0002093
46 emphysema64 HP:0002097
47 bronchiectasis64 HP:0002110
48 recurrent respiratory infections64 HP:0002205
49 bowel incontinence64 HP:0002607
50 scoliosis64 HP:0002650
51 short nose64 HP:0003196
52 abnormality of the hip bone64 HP:0003272
53 short stature64 HP:0004322
54 cachexia64 HP:0004326
55 ectopic anus64 HP:0004397
56 bowel diverticulosis64 HP:0005222
57 excessive wrinkled skin64 HP:0007392
58 abnormality of retinal pigmentation64 HP:0007703
59 abnormal blistering of the skin64 HP:0008066
60 aplasia/hypoplasia of the tongue64 HP:0010295
61 aplasia/hypoplasia of the abdominal wall musculature64 HP:0010318
62 erythema64 HP:0010783
63 prominent forehead64 HP:0011220
64 midface retrusion64 HP:0011800
65 esophageal diverticulum64 HP:0100628
66 lack of skin elasticity64 HP:0100679
67 exostoses64 HP:0100777
68 genital hernia64 HP:0100823

UMLS symptoms related to Cutis Laxa:


pruritus

MGI Mouse Phenotypes related to Cutis Laxa according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4ABCC6, EFEMP2, FBLN5, FBN1, LTBP4

Drugs & Therapeutics for Cutis Laxa

About this section

Drugs for Cutis Laxa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 73)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Lidocaineapproved, vet_approvedPhase 4, Phase 31317137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
2
Epinephrineapproved, vet_approvedPhase 4, Phase 398551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
3
Glycerolexperimental, approvedPhase 423856-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
4Epinephryl boratePhase 4, Phase 3985
5RacepinephrinePhase 4, Phase 3985
6AnestheticsPhase 4, Phase 39596
7Central Nervous System DepressantsPhase 4, Phase 313403
8
LoratadineapprovedPhase 310079794-75-53957
Synonyms:
1-Piperidenecarboxylic acid, 4-(8-chloro-5,6-duhydro-11H-benzo [5,6]cyclohepta[1,2-b]-pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
1-piperidinecarboxylic acid,4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-,ethyl ester
4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptal[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
79794-75-5
AC-2086
AC1L1H3E
Aerotina
Alarin
Alavert
Alavert, Claritin, Loratadine
Alerpriv
Allertidin
Amantadine
Anhissen
BB_SC-2109
BIDD:GT0198
BRD-K82795137-001-02-3
BRD-K82795137-001-10-6
BSPBio_002300
Bedix Loratadina
Biloina
Bonalerg
C22H23ClN2O2
CHEMBL998
CID3957
CPD000058255
Children's Claritin
Civeran
Claratyne
Claratyne Cold
Claratyne Decongestant
Clarinase
Clarinase Reperabs
Claritin
Claritin (TN)
Claritin D
Claritin Hives Relief
Claritin Hives Relief Reditab
Claritin Reditabs
Claritin reditab
Claritine
Clarityn
Clarityne
Clarityne Dy Repetabs
Clarityne-D
Clarium
Cronopen
D00364
D017336
DB00455
DivK1c_000792
EU-0100680
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate
Flonidan
Fristamin
HMS2051G11
HMS2090O18
HMS2093I15
HMS502H14
HSDB 3578
Histaloran
I14-0747
IDI1_000792
KBio1_000792
KBio2_001976
KBio2_004544
KBio2_007112
KBio3_001520
KBioGR_000693
KBioSS_001976
Klaritin
L 9664
L000667
L0223
L9664_SIGMA
LS-114660
 
Lergy
Lertamine
Lesidas
Lisino
Lopac-L-9664
Lopac0_000680
Loracert
Loradex
Loradif
Loranox
Lorantis
Lorastine
Loratadina
Loratadina [Spanish]
Loratadine
Loratadine (JAN/USAN/INN)
Loratadine Redidose
Loratadine Wyeth Brand
Loratadine [USAN:BAN:INN]
Loratadinum
Loratadinum [Latin]
Loratidine
Loratyne
Loraver
Lorfast
Loritine
Lowadina
MLS000069647
MLS000758260
MLS001148466
MolPort-002-507-846
NCGC00015619-01
NCGC00015619-02
NCGC00015619-06
NCGC00015619-10
NCGC00023125-02
NCGC00023125-04
NCGC00023125-05
NCGC00023125-06
NCGC00023125-07
NCI60_041473
NINDS_000792
NSC721075
Nularef
Oprea1_027965
Optimin
Polaratyne
Pylor
Restamine
Rhinase
Rinomex
Roletra
S1358_Selleck
SAM001246987
SMR000058255
SPBio_001548
SPECTRUM1503712
STK574925
Sanelor
Sch 29851
Sch-29851
Sch29851
Sensibit
Sinhistan Dy
Sohotin
Spectrum2_001584
Spectrum3_000740
Spectrum4_000177
Spectrum5_001650
Spectrum_001496
TL8005389
Tadine
Talorat Dy
Tocris-1944
UNII-7AJO3BO7QN
Velodan
Versal
Wyeth Brand of Loratadine
ZINC00537931
Zeos
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
loratadine
9
IbuprofenapprovedPhase 351815687-27-13672
Synonyms:
(4-isobutylphenyl)-α-methylacetic acid
(RS)-ibuprofen
(±)-2-(p-isobutylphenyl)propionic acid
(±)-ibuprofen
(±)-p-isobutylhydratropic acid
(±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid
139466-08-3
15687-27-1
2-(4-isobutylphenyl)propanoic acid
4-isobutylhydratropic acid
58560-75-1
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
ARONIS23835
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Liqui-Gels
Ak+C2278tren
Alaxan
Algofen
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
Artofen
Artril
Artril 300
BB_SC-1358
BIDD:GT0050
BRN 2049713
Balkaprofen
Betaprofen
Bloom
Bluton
Brofen
Brufanic
Brufen
Brufen 400
Bruflam
Brufort
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butylenin
C01588
C13H18O2
CCRIS 3223
CHEBI:5855
CHEMBL521
CID3672
CPD000058184
Cap-Profen
Carol
Cesra
Children's Advil
Children's Elixsure
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Combiflam
Cunil
D00126
D007052
DB01050
DOLO PUREN
Daiprophen
Dalsy
Dansida
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
Dolo-Dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
Duafen
Duobrus
Dura-Ibu
Duralbuprofen
Dysdolen
EU-0100691
Easifon
Ebufac
Emflam
Emflam-200
Emodin
Epobron
Eputex
Ergix
Esprenit
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Gofen
Grefen
Gynofug
HMS1920F15
HMS2089P05
HMS2091N03
HMS502M09
HSDB 3099
Haltran
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
IDI1_000887
IP 82
IP-82
IP82
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-Slo
Ibu-Tab
Ibu-Tab 200
Ibu-slo
Ibu-slow
Ibubest
Ibubeta
Ibucasen
Ibudol
Ibudolor
 
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofene
Ibuprofeno
Ibuprofenum
Ibuprohm
Ibuprophen
Ibusal
Ibutid
Ifen
Inabrin
Inflam
Inoven
Ipren
Irfen
Isodol
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
Kesan
Kratalgin
LS-7454
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopane
MLS000069733
MLS001146965
Malafene
Manypren
Medipren
Melfen
Mensoton
Midol
Midol 200
Moment
Motrin
Motrin (TN)
Motrin IB
Mynosedin
NCI60_002065
NINDS_000887
NSC 256857
NSC256857
Nagifen-D
Napacetin
Narfen
Neo-Helvagit
Neo-Mindol
NeoProfen
Neobrufen
Nerofen
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo-Profen
Novogent
Novogent N
Novoprofen
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
P-Isobutylhydratropic Acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
Pediaprofen
Pediatric Advil
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
RD 13621
Rafen
Ranofen
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
SAM002264619
SMR000058184
SPBio_000178
STK177358
Sadefen
Salivia
Salprofen
Seclodin
Sednafen
Seklodin
Seskafen
Siyafen
Solpaflex
Solufen
Stelar
Sugafen
Suprafen
Suspren
Syntofene
TL8001184
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
Tofen
Togal N
Tonal
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
Zafen
Zofen
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
ibuprofen
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
α-(4-isobutylphenyl)propionic acid
α-(p-isobutylphenyl)propionic acid
10
deoxycholic acidapprovedPhase 3, Phase 1, Phase 24083-44-3222528
Synonyms:
(3α,5β,12α)-3,12-dihydroxycholan-24-oic acid
3alpha,12alpha-Dihydroxy-5beta-cholanic acid
5b-Cholanic acid-3a,12a-diol
5b-Deoxycholate
5b-Deoxycholic acid
7-Deoxycholate
7-Deoxycholic acid
7α-deoxycholic acid
Cholerebic
 
Cholorebic
Degalol
Deoxy-Cholate
Deoxy-Cholic acid
Deoxycholatate
Deoxycholate
Deoxycholatic acid
Deoxycholic acid
Desoxycholsäure
deoxycholate
desoxycholic acid
11
Histamineapproved, investigationalPhase 3105075614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-(4-imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
4-imidazoleethylamine
5-Imidazoleethylamine
5-imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminoethylglyoxaline
beta-aminoethylimidazole
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
12
CopperapprovedPhase 318115158-11-9, 7440-50-827099
Synonyms:
 
Copper
Cu
13Histamine H1 AntagonistsPhase 3791
14Dermatologic AgentsPhase 35806
15Histamine H1 Antagonists, Non-SedatingPhase 3359
16Diuretics, Potassium SparingPhase 31917
17Gastrointestinal AgentsPhase 3, Phase 1, Phase 28402
18Histamine AntagonistsPhase 3961
19Peripheral Nervous System AgentsPhase 323689
20Sodium Channel BlockersPhase 31593
21Vasoconstrictor AgentsPhase 32122
22Respiratory System AgentsPhase 34997
23Pharmaceutical SolutionsPhase 3, Phase 2, Early Phase 18192
24Neurotransmitter AgentsPhase 318340
25
Histamine PhosphatePhase 3104951-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
LS-78569
UNII-QWB37T4WZZ
26MydriaticsPhase 3811
27Analgesics, Non-NarcoticPhase 36501
28Anesthetics, LocalPhase 33492
29Anti-Allergic AgentsPhase 31522
30AnalgesicsPhase 311733
31Adrenergic beta-AgonistsPhase 31714
32Cyclooxygenase InhibitorsPhase 32870
33Adrenergic AgonistsPhase 33027
34Adrenergic alpha-AgonistsPhase 31734
35Anti-Arrhythmia AgentsPhase 33093
36Adrenergic AgentsPhase 35352
37Autonomic AgentsPhase 310150
38Anti-Asthmatic AgentsPhase 33488
39Cholagogues and CholereticsPhase 3, Phase 1, Phase 2130
40Antirheumatic AgentsPhase 310956
41Bronchodilator AgentsPhase 32965
42Anti-Inflammatory Agents, Non-SteroidalPhase 34443
43Anti-Inflammatory AgentsPhase 310729
44AntipruriticsPhase 3841
45Trace ElementsPhase 36001
46MicronutrientsPhase 36001
47histidineNutraceuticalPhase 345
48
Hydrocodoneapproved, illicit123125-29-15284569
Synonyms:
(-)-Dihydrocodeinone
(5alpha)-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one
1037-91-8
125-29-1
3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one
34195-34-1 (tartrate (1:1), hydrate (2:5))
4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
4,5.alpha.-Epoxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one
4-27-00-03580 (Beilstein Handbook Reference)
50678-79-0
6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan
9007-52-7
BRN 0094193
Bekadid
C08024
CHEBI:5779
CHEMBL1457
CID5284569
Codinovo
D08045
DB00956
DEA No. 9193
DICO
Dico
Dicodid
Dihydrocodeinone
EINECS 204-733-9
 
HSDB 3097
HYDROCODONE
Hidrocodona
Hidrocodona [INN-Spanish]
Hydrocodeinonebitartrate
Hydrocodon
Hydrocodone
Hydrocodone (INN)
Hydrocodone [INN:BAN]
Hydrocodonum
Hydrocodonum [INN-Latin]
Hydrocon
Hydrocone
Hydroconum
Idrocodone
Idrocodone [DCIT]
Idrocodone [Dcit]
LS-92156
MolPort-002-527-170
Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)- (9CI)
Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl- (8CI)
Multacodin
NCGC00159317-02
NCGC00159317-03
NSC 19044
NSC19044
STOCK1N-54181
UNII-6YKS4Y3WQ7
WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1
hidrocodona
49
Hyaluronic acidapproved, vet_approved4699004-61-953477741, 24759
Synonyms:
Hyaluronan
Hyaluronate
Hyaluronic acid
Hylartil
Hyruan Plus
Luronit
 
Macronan
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sofast
Synvisc
50
Acetylcholineapproved80551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride

Interventional clinical trials:

(show top 50)    (show all 61)
idNameStatusNCT IDPhase
1Suture Granuloma in Body Contouring SurgeryCompletedNCT00223132Phase 4
2Vibration-Assisted AnaesthesiaCompletedNCT00793988Phase 4
3Change in Skin Elasticity With RF and PEMFRecruitingNCT03002194Phase 4
4Patient Experience Study of Deoxycholic Acid InjectionCompletedNCT02007434Phase 3
5Safety Study of ATX-101 in Subjects With Varying Chin SizesCompletedNCT02035267Phase 3
6Open-Label Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental AreaCompletedNCT01426373Phase 3
7Molecular Bases of Response to Copper Treatment in Menkes Disease, Related Phenotypes, and Unexplained Copper DeficiencyRecruitingNCT00811785Phase 3
8Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental FatCompletedNCT00618722Phase 1, Phase 2
9Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)CompletedNCT02230761Phase 2
10Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental FatCompletedNCT00618618Phase 2
11The Effect of Eyelid Surgery on Dry Eye - a Prospective StudyUnknown statusNCT02376556
12Efficacy Study for Magnetic Induction to Treat WrinklesUnknown statusNCT01701440
13Levator Muscle Strength EvaluationUnknown statusNCT02226016
14Feasibility Study: Evaluation of the Ulthera® System for Treatment of the KneesCompletedNCT01708434
15Evaluation of the Ulthera™ System for Obtaining Lift and Tightening of the Cheek TissueCompletedNCT01368835
16Feasibility Study: Higher Density Ulthera® System Treatment With Vectoring for Treatment of the Face and NeckCompletedNCT01708512
17Lifting and Tightening of the Face in Subjects With Skin of Darker ColorCompletedNCT01368965
18Ultherapy™ Treatment Following Sculptra® TreatmentCompletedNCT01422538
19Feasibility Study: Lifting and Tightening of the ElbowsCompletedNCT01708382
20Lifting and Tightening of the Face and Neck Following an Increased Density TreatmentCompletedNCT01519206
21Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ TreatmentsCompletedNCT01708473
22Application of the Apsara Thermal Wand SystemCompletedNCT00662389Early Phase 1
23Feasibility Study: Evaluate the Effectiveness of Using a Topical Anesthetic Prior to Ultherapy™ TreatmentCompletedNCT01708447
24Treatment of the Face and Neck With Lower Ulthera System Energy SettingsCompletedNCT01713998
25Safety and Effectiveness Evaluation of the Device in Achieving Submental LiftCompletedNCT02832674
26Feasibility Study: Treatment of Post-surgery and Surgery Naive Patients Who Failed to Respond to a Previous Ulthera TreatmentCompletedNCT01708252
27Feasibility Study: Evaluation of the Ulthera® System for Treatment of the DécolletéCompletedNCT01485107
28Feasibility Study: Lifting and Tightening Neck Skin in PatientsCompletedNCT01708928
29Feasibility Study: Heavy Water Tissue Labeling ProtocolCompletedNCT01708525
30Feasibility Study: Ulthera Treatment of the Buttocks and ThighsCompletedNCT01708460
31Ultherapy® for Treating the Face and Neck Using Standard Versus Simulines TransducersCompletedNCT02416076
32Retrospective Evaluation of Combination Treatment With the Ulthera SystemCompletedNCT02444169
33Efficacy of Long Pulsed 1064nm Laser for Facial Skin TighteningCompletedNCT01971736
34Lifting and Tightening of the Face and Neck Utilizing the Ulthera® SystemCompletedNCT01368874
35Evaluation of CoolSculpt Combining Venus Legacy Technology for Enhanced Results in Fat Reduction and Laxity of the FlanksCompletedNCT02569112
36Feasibility Study: Evaluation of Ulthera Versus Thermage for Treating the Face and NeckCompletedNCT01713985
37Feasibility Study: Evaluation of the Ulthera® System for Treatment of Abdominal TissueCompletedNCT01708499
38A Retrospective Study to Evaluate the Effectiveness of the Ulthera SystemCompletedNCT01519934
39Use of 2-octyl-cyanoacrylate Together With a Self-adhering MeshCompletedNCT01658163
40Evaluation of the Ulthera® System for Treatment of the BrachiaCompletedNCT01713933
41Silk'n HST for Wrinkle Reduction - Clinical Study ProtocolCompletedNCT02913547
42Clinical Trial to Evaluate Safety and Efficacy of Ultherapy™ System for Lifting Skin on the NeckCompletedNCT02368925
43Evaluation of Safety and Efficacy of Using Imagine™ Computerized Radiofrequency System for Skin TighteningCompletedNCT00945685
44Evaluation of Safety and Efficacy of Using EndyMed Pro Skin Treatment System for Skin Wrinkle Treatment on Body AreasCompletedNCT01029301
45Comparison of the Effects of Carboxytherapy and Radiofrequency on Skin RejuvenationCompletedNCT01981980
46Thermage CPT for Treatment of Facial and Neck LaxityCompletedNCT01783496
47Safety and Efficacy Evaluation of Ultherapy™ System in Aging HandCompletedNCT02364440
48Body Contouring Surgery After Massive Weight LossCompletedNCT02174458
49Condition of Submental Fullness and Treatment Outcomes RegistryCompletedNCT02438813
50Gene Expression Following Ultherapy® TreatmentRecruitingNCT02441036

Search NIH Clinical Center for Cutis Laxa


Cochrane evidence based reviews: cutis laxa

Genetic Tests for Cutis Laxa

About this section

Genetic tests related to Cutis Laxa:

id Genetic test Affiliating Genes
1 Cutis Laxa27

Anatomical Context for Cutis Laxa

About this section

MalaCards organs/tissues related to Cutis Laxa:

36
Skin, Heart, Lung, Bone, Tongue, Brain, Neutrophil

Publications for Cutis Laxa

About this section

Articles related to Cutis Laxa:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Cutis laxa autosomal recessive type II or wrinkly skin syndrome? (27730053)
2016
2
A de novo 1q23.3-q24.2 deletion combined with a GORAB missense mutation causes a distinctive phenotype with cutis laxa. (27604556)
2016
3
Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration. (27873303)
2016
4
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa. (27339457)
2016
5
A 5-year Journey with Cutis Laxa in an Indian Child: The De Barsy Syndrome Revisited. (26955101)
2016
6
Polymicrogyria and myoclonic epilepsy in autosomal recessive cutis laxa type 2A. (27631729)
2016
7
Generalized acquired cutis laxa type 1: a case report and brief review of literature. (27136630)
2016
8
Frequency of cutis laxa-like clinical features and elastolysis in scleromyxedema: a retrospective clinicopathologic study of 19 patients with scleromyxedema. (26676919)
2016
9
Neonatal Cutis Laxa and Hypertrichosis Lanuginosa in Sotos Syndrome. (27601358)
2016
10
Acquired Localized Cutis Laxa due to Increased Elastin Turnover. (27293393)
2016
11
ALDH18A1-related cutis laxa syndrome with cyclic vomiting. (26829900)
2016
12
Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa. (28065471)
2016
13
Penicillamine-associated cutis laxa and milia en plaque - case report and review of cutaneous changes associated with penicillamine. (27617526)
2016
14
Developmental retardation in postinflammatory elastolysis and cutis laxa. (26345649)
2015
15
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. (25497952)
2015
16
The Diagnostic Dilemma of Cutis Laxa: A Report of Two Cases with Genotypic Dissimilarity. (26538727)
2015
17
Congenital Cutis Laxa Type 2 Associated With Recurrent Aspiration Pneumonia and Growth Delay: Case Report. (26516448)
2015
18
Generalized acquired cutis laxa with papular lesions. (25516168)
2015
19
Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa. (26320891)
2015
20
Fractional photothermolysis treatment of digital cutis laxa reverses hand disability. (25808794)
2015
21
Acquired localized cutis laxa occurring on the face after delivery. (25652808)
2015
22
Clinical presentation of a patient with cutis laxa with systemic involvement: a case report. (26662161)
2015
23
Autosomal-dominant cutis laxa resulting from an intronic mutation in ELN. (26121527)
2015
24
Modeling autosomal recessive cutis laxa type 1C (ARCL1C) in mice reveals distinct functions of Ltbp-4 isoforms. (25713297)
2015
25
Acquired cutis laxa associated with cutaneous mastocytosis. (26436968)
2015
26
Cutis Laxa syndrome: a case report. (25995800)
2015
27
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. (26178373)
2015
28
Cutis laxa presenting as recurrent ileus. (25008264)
2014
29
Acquired cutis laxa: diagnostic and therapeutic considerations. (25027942)
2014
30
Baroreflex failure, sympathetic storm, and cerebral vasospasm in fibulin-4 cutis laxa. (24733866)
2014
31
Cutis laxa, fat pads and retinopathy due to ALDH18A1 mutation and review of the literature. (24767728)
2014
32
Loss of ALDH18A1 function is associated with a cellular lipid droplet phenotype suggesting a link between autosomal recessive cutis laxa type 3A and Warburg Micro syndrome. (25077174)
2014
33
Severe congenital cutis laxa with cardiovascular manifestations due to homozygous deletions in ALDH18A1. (24913064)
2014
34
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. (24962763)
2014
35
Biomechanical properties of the skin in cutis laxa. (24844858)
2014
36
Autosomal recessive cutis laxa type 2A (ARCL2A) mimicking Ehlers-Danlos syndrome by its dermatological manifestations: report of three affected patients. (24478233)
2014
37
Bilateral congenital entropion with cutis laxa. (24517732)
2014
38
A novel phenotype associated with cutis laxa, abnormal fat distribution, cardiomyopathy and cataract. (24459010)
2014
39
A novel elastin gene mutation in a Vietnamese patient with cutis laxa. (24758204)
2014
40
Acquired cutis laxa of face with multiple myeloma. (25201849)
2014
41
Identification of two novel ATP6V0A2 mutations in an infant with cutis laxa by exome sequencing. (24815019)
2014
42
Clinical presentation of a patient with congenital cutis laxa and abnormal thyroid hormone levels. (24707249)
2014
43
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. (25133950)
2014
44
Postoperative intussusception in a neonate with congenital cutis laxa and huge hiatal hernia. (24834384)
2014
45
Retinitis pigmentosa, cutis laxa, and pseudoxanthoma elasticum-like skin manifestations associated with GGCX mutations. (24739904)
2014
46
Trachyonychia, Cutis Laxa, and Easy Bruising of the Skin. (25322068)
2014
47
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. (24676529)
2014
48
Clinical and biochemical features guiding the diagnostics in neurometabolic cutis laxa. (23963297)
2013
49
Oculoplastic approach to congenital cutis laxa syndrome. (23443999)
2013
50
Cutis laxa type II with mutation in the pyrroline-5-carboxylate reductase 1 gene. (23406396)
2013

Variations for Cutis Laxa

About this section

Clinvar genetic disease variations for Cutis Laxa:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ABCC6NM_ 001171.5(ABCC6): c.3421C> T (p.Arg1141Ter)SNVPathogenicrs72653706GRCh37Chr 16, 16256935: 16256935

Expression for genes affiliated with Cutis Laxa

About this section
Search GEO for disease gene expression data for Cutis Laxa.

Pathways for genes affiliated with Cutis Laxa

About this section

GO Terms for genes affiliated with Cutis Laxa

About this section

Cellular components related to Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1elastic fiberGO:007195310.5ELN, FBLN5
2extracellular matrixGO:00310129.6FBLN5, FBN1, LTBP4
3proteinaceous extracellular matrixGO:00055788.6ELN, FBLN5, FBN1, LTBP4

Biological processes related to Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular amino acid biosynthetic processGO:000865210.2ALDH18A1, PYCR1
2L-proline biosynthetic processGO:00551299.8ALDH18A1, PYCR1
3proline biosynthetic processGO:00065619.6ALDH18A1, PYCR1
4extracellular matrix organizationGO:00301989.5ELN, FBLN5, FBN1

Molecular functions related to Cutis Laxa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00052019.8EFEMP2, ELN, FBN1
2calcium ion bindingGO:00055099.2EFEMP2, FBLN5, FBN1, LTBP4
3integrin bindingGO:00051789.0FBLN5, FBN1, LTBP4

Sources for Cutis Laxa

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet