MCID: CYC007
MIFTS: 27

Cyclic Thrombocytopenia malady

Blood category

Summaries for Cyclic Thrombocytopenia

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cyclic Thrombocytopenia, also known as thrombocytopenia, cyclic, is related to thrombocytopenia and thrombocytosis. An important gene associated with Cyclic Thrombocytopenia is THPO (thrombopoietin), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds bortezomib and il 11 have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Aliases & Classifications for Cyclic Thrombocytopenia

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

cyclic thrombocytopenia 43
thrombocytopenia, cyclic 45 61
thrombocytopenia cyclic 43


Related Diseases for Cyclic Thrombocytopenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cyclic Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.2IL3, IL6, THPO
2thrombocytosis30.4THPO, IL3, IL6
3polycythemia vera30.0THPO, IL3
4hemoglobin d disease10.0
5hemoglobin e disease10.0
6hemoglobin c disease10.0
7acquired thrombocytopenia10.0
8common variable immunodeficiency10.0
9paraneoplastic syndromes10.0IL6
10inflammatory bowel disease10.0IL6
11multiple myeloma10.0IL6
12respiratory failure10.0IL6
13hepatoblastoma10.0THPO
14pneumonia10.0IL6
15chronic myeloproliferative disease10.0THPO
16atherosclerosis10.0IL6
17disseminated intravascular coagulation10.0THPO
18myelofibrosis10.0THPO
19hepatitis c10.0THPO
20severe combined immunodeficiency10.0IL3
21sarcoma10.0THPO
22arthritis10.0IL6
23acute pancreatitis10.0IL6
24galactosemia10.0THPO, IL6
25multiple sclerosis10.0THPO, IL6
26rheumatoid arthritis10.0THPO, IL6
27congenital amegakaryocytic thrombocytopenia10.0THPO, IL3
28leukopenia10.0IL3, IL6
29polycythemia10.0THPO, IL3
30myeloma10.0IL6, IL3
31neutropenia10.0IL3, THPO
32severe congenital neutropenia10.0IL3, THPO
33megakaryocytic leukemia10.0THPO, IL3
34refractory anemia10.0THPO, IL3
35coronary artery disease,10.0THPO, IL6
36hemorrhagic thrombocythemia10.0IL3, THPO
37fanconi's anemia10.0THPO, IL3
38myelodysplastic syndromes10.0THPO, IL3
39acute leukemia10.0THPO, IL3
40aplastic anemia10.0THPO, IL3
41pancytopenia10.0THPO, IL3
42myeloproliferative disorder10.0THPO, IL3
43diamond-blackfan anemia 110.0IL3, THPO
44chronic kidney failure10.0IL6, THPO
45ulcerative colitis10.0IL6, THPO
46hematologic cancer10.0THPO, IL3
47acute erythroid leukemia10.0IL3, THPO
48myeloid leukemia10.0IL3, THPO
49chronic myeloid leukemia10.0THPO, IL3
50deficiency anemia10.0IL6, IL3, THPO

Graphical network of the top 20 diseases related to Cyclic Thrombocytopenia:



Diseases related to cyclic thrombocytopenia

Clinical Features for Cyclic Thrombocytopenia

Drugs & Therapeutics for Cyclic Thrombocytopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cyclic Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Cyclic Thrombocytopenia

Search NIH Clinical Center for Cyclic Thrombocytopenia

Search CenterWatch for Cyclic Thrombocytopenia

Genetic Tests for Cyclic Thrombocytopenia

Anatomical Context for Cyclic Thrombocytopenia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cyclic Thrombocytopenia:

33
T cells

Animal Models for Cyclic Thrombocytopenia or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Cyclic Thrombocytopenia

Sources:
51PubMed
See all sources

Articles related to Cyclic Thrombocytopenia:

(show all 36)
idTitleAuthorsYear
1
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. (22038676)
2012
2
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. (19484732)
2009
3
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. (19728020)
2009
4
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. (17135540)
2006
5
Human cyclic thrombocytopenia and Anaplasma spp. infection. (15654914)
2005
6
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? (15650554)
2005
7
Investigation of persistent hypochromic microcytosis unmasks hemoglobin Evanston [alpha 14 (A12) Try--> Arg] in a patient of cyclic thrombocytopenia preceding Takayasu's disease. (16273737)
2005
8
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. (16044437)
2005
9
Idiopathic cyclic thrombocytopenia. (15572217)
2005
10
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. (15205594)
2004
11
Cyclic thrombocytopenia and polycythemia vera. (12574969)
2003
12
Clonal T cell-mediated cyclic thrombocytopenia. (12472588)
2002
13
Effective treatment of cyclic thrombocytopenia with cepharanthin. (10530079)
1999
14
Clinical manifestations of infectious canine cyclic thrombocytopenia. (9308149)
1997
15
Cyclic thrombocytopenia in a patient treated with cyclosporine for refractory idiopathic thrombocytopenic purpura. (9395191)
1997
16
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. (8757531)
1996
17
Canine infectious cyclic thrombocytopenia found in Taiwan. (8741613)
1996
18
Serum thrombopoietin levels in cyclic thrombocytopenia. (8639873)
1996
19
Megakaryopoiesis in patients with cyclic thrombocytopenia. (7577630)
1995
20
Cyclic thrombocytopenia successfully treated with low dose hormonal contraception. (7832199)
1995
21
Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. (7496073)
1995
22
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
23
Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies. (7529542)
1994
24
Periodic production of antiplatelet autoantibody directed against GPIIIa in cyclic thrombocytopenia. (8362605)
1993
25
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. (7918035)
1993
26
Cell-mediated cyclic thrombocytopenia treated with azathioprine. (2012761)
1991
27
Danazol therapy for cyclic thrombocytopenia. (2012064)
1991
28
Menstrual cyclic thrombocytopenia. (2713272)
1989
29
Cyclic thrombocytopenia of apparent autoimmune etiology. (2713494)
1989
30
Idiopathic cyclic thrombocytopenia of childhood. (2712241)
1989
31
Serologic diagnosis of infectious cyclic thrombocytopenia in dogs using an indirect fluorescent antibody test. (6362502)
1983
32
Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. (627738)
1978
33
Cyclic thrombocytopenia: a thrombopoietin deficiency? (4832304)
1974
34
Cyclic thrombocytopenia. Case report and review of literature. (4598703)
1974
35
Cyclic thrombocytopenia associated with multiple autoantibodies. (5797783)
1969
36
Cyclic thrombocytopenia of acute type. (4295269)
1967

Genetic Variations for Cyclic Thrombocytopenia

Expression for genes affiliated with Cyclic Thrombocytopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cyclic Thrombocytopenia

Search GEO for disease gene expression data for Cyclic Thrombocytopenia.

Pathways for genes affiliated with Cyclic Thrombocytopenia

Sources:
52QIAGEN, 53R&D Systems, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9THPO
2
Hide members
9.7IL3
3
Hide members
9.3IL6, THPO
4
Hide members
9.1IL6, IL3
59.1IL6, IL3
69.1IL3, IL6
7
Hide members
9.1IL6, IL3
89.1IL6, IL3
99.1IL3, IL6
10
Hide members
8.5IL6, THPO, IL3
11
Hide members
8.5THPO, IL3, IL6
12
Hide members
8.5IL3, IL6, THPO
13
Hide members
8.5IL6, IL3, THPO
148.5THPO, IL3, IL6
15
Hide members
8.5IL3, IL6, THPO
16
Hide members
8.5IL3, IL6, THPO
17
Hide members
8.5THPO, IL3, IL6
18
Hide members
8.5THPO, IL3, IL6
19
Hide members
8.5THPO, IL6, IL3
20
Hide members
8.5THPO, IL6, IL3

Compounds for genes affiliated with Cyclic Thrombocytopenia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1bortezomib45 1110.6THPO, IL6
2il 11459.6IL6, IL3
3tgf beta1459.6IL6, THPO
4mip 1alpha459.5IL6, IL3
5hyaluronic acid45 2410.5THPO, IL6
6anaphylatoxin459.5IL6, IL3
7poly(i-c)459.5IL6, IL3
8il 10459.5IL6, IL3
9ivig459.5IL3, IL6
10melphalan45 1110.5IL6, IL3
11neopterin459.5IL3, IL6
12mafosfamide459.5THPO, IL3
13amifostine45 1110.4THPO, IL3
14ifosfamide45 1110.4THPO, IL3
15leucovorin45 50 1111.4IL3, THPO
16leukotriene b445 60 2411.4IL6, IL3
17carboplatin45 50 1111.3IL3, THPO
18herbimycin a45 6010.3IL6, IL3
19hydroxyurea45 50 1111.3THPO, IL3
20cytarabine45 50 1111.3THPO, IL3
21imatinib45 50 1111.2IL3, THPO
225-aza-2deoxycytidine459.1THPO, IL3
23fmlp459.1THPO, IL3
24prostacyclin459.0IL3, THPO
25calcitriol45 60 11 2412.0IL6, IL3
26agar459.0THPO, IL3
27pixy321458.9THPO, IL6, IL3
28filgrastim45 119.9THPO, IL6, IL3
29gm-csf45 299.9IL3, IL6, THPO
30methylcellulose458.9THPO, IL6, IL3
31gp 130458.9IL3, IL6, THPO
32rantes458.9IL3, IL6, THPO
33histamine45 29 2410.9IL3, IL6, THPO
34pd 98,059458.9THPO, IL6, IL3
35ly294002458.9THPO, IL6, IL3
36actinomycin d458.9IL3, IL6, THPO
37genistein45 29 60 2 11 2413.9THPO, IL6, IL3
38lactate458.9IL3, IL6, THPO
39thymidine45 249.9THPO, IL6, IL3
40creatinine458.9IL3, IL6, THPO
41dexamethasone45 50 29 1111.9IL3, IL6, THPO
42alanine458.8THPO, IL6, IL3
43estrogen458.8THPO, IL6, IL3
44retinoic acid45 249.8IL3, IL6, THPO
455fluorouracil458.7THPO, IL3

GO Terms for genes affiliated with Cyclic Thrombocytopenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5THPO, IL6, IL3

Biological processes related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3THPO, IL6
2positive regulation of DNA replicationGO:0457409.0IL6, IL3
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8IL6, IL3

Molecular functions related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5THPO, IL6, IL3
2growth factor activityGO:0080838.2THPO, IL6, IL3

Products for genes affiliated with Cyclic Thrombocytopenia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cyclic Thrombocytopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet