MCID: CYC007
MIFTS: 23

Cyclic Thrombocytopenia malady

Blood diseases category

Summaries for Cyclic Thrombocytopenia

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32MalaCards
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MalaCards: Cyclic Thrombocytopenia, also known as thrombocytopenia, cyclic, is related to thrombocytopenia and thrombocytosis. An important gene associated with Cyclic Thrombocytopenia is THPO (thrombopoietin), and among its related pathways are Rho Family GTPases and PAK Pathway. The compounds bortezomib and il 11 have been mentioned in the context of this disorder.

Aliases & Classifications for Cyclic Thrombocytopenia

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

cyclic thrombocytopenia 42
thrombocytopenia, cyclic 44 60
thrombocytopenia cyclic 42


Related Diseases for Cyclic Thrombocytopenia

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17GeneCards, 18GeneDecks
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Diseases related to Cyclic Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.1IL3, IL6, THPO
2thrombocytosis30.3THPO, IL3, IL6
3polycythemia vera30.0THPO, IL3
4polycythemia30.0THPO, IL3
5acquired thrombocytopenia10.0
6common variable immunodeficiency10.0
7purpura10.0
8paraneoplastic syndromes10.0IL6
9inflammatory bowel disease10.0IL6
10multiple myeloma10.0IL6
11respiratory failure10.0IL6
12hepatoblastoma10.0THPO
13pneumonia10.0IL6
14chronic myeloproliferative disease10.0THPO
15atherosclerosis10.0IL6
16disseminated intravascular coagulation10.0THPO
17myelofibrosis10.0THPO
18hepatitis c10.0THPO
19severe combined immunodeficiency10.0IL3
20sarcoma10.0THPO
21arthritis10.0IL6
22acute pancreatitis10.0IL6
23galactosemia10.0THPO, IL6
24multiple sclerosis10.0THPO, IL6
25rheumatoid arthritis10.0THPO, IL6
26congenital amegakaryocytic thrombocytopenia10.0THPO, IL3
27leukopenia10.0IL3, IL6
28myeloma10.0IL6, IL3
29neutropenia10.0IL3, THPO
30severe congenital neutropenia10.0IL3, THPO
31megakaryocytic leukemia10.0THPO, IL3
32refractory anemia10.0THPO, IL3
33coronary artery disease10.0THPO, IL6
34hemorrhagic thrombocythemia10.0IL3, THPO
35fanconi's anemia10.0THPO, IL3
36myelodysplastic syndromes10.0THPO, IL3
37acute leukemia10.0THPO, IL3
38aplastic anemia10.0THPO, IL3
39pancytopenia10.0THPO, IL3
40myeloproliferative disorder10.0THPO, IL3
41diamond-blackfan anemia 110.0IL3, THPO
42chronic kidney failure10.0IL6, THPO
43ulcerative colitis10.0IL6, THPO
44hematologic cancer10.0THPO, IL3
45acute erythroid leukemia10.0IL3, THPO
46myeloid leukemia10.0IL3, THPO
47chronic myeloid leukemia10.0THPO, IL3
48deficiency anemia10.0IL6, IL3, THPO
49acute lymphocytic leukemia10.0IL3, THPO

Graphical network of the top 20 diseases related to Cyclic Thrombocytopenia:



Diseases related to cyclic thrombocytopenia

Clinical Features for Cyclic Thrombocytopenia

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Drugs & Therapeutics for Cyclic Thrombocytopenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cyclic Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Cyclic Thrombocytopenia

Search NIH Clinical Center for Cyclic Thrombocytopenia

Search CenterWatch for Cyclic Thrombocytopenia

Genetic Tests for Cyclic Thrombocytopenia

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Anatomical Context for Cyclic Thrombocytopenia

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Animal Models for Cyclic Thrombocytopenia or affiliated genes

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Publications for Cyclic Thrombocytopenia

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Genetic Variations for Cyclic Thrombocytopenia

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Expression for genes affiliated with Cyclic Thrombocytopenia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cyclic Thrombocytopenia

Search GEO for disease gene expression data for Cyclic Thrombocytopenia.

Pathways for genes affiliated with Cyclic Thrombocytopenia

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51QIAGEN, 52R&D Systems, 12EMD Millipore, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9THPO
2
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9.7IL3
3
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9.3IL6, THPO
4
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9.1IL6, IL3
59.1IL6, IL3
6
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9.1IL6, IL3
79.1IL3, IL6
89.1IL3, IL6
99.1IL6, IL3
10
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8.5IL3, IL6, THPO
11
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8.5IL3, IL6, THPO
12
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8.5IL3, IL6, THPO
13
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8.5IL3, IL6, THPO
14
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8.5THPO, IL6, IL3
15
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8.5THPO, IL6, IL3
16
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8.5THPO, IL6, IL3
17
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8.5THPO, IL6, IL3
18
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8.5THPO, IL6, IL3
198.5THPO, IL6, IL3
20
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8.5THPO, IL6, IL3

Compounds for genes affiliated with Cyclic Thrombocytopenia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1bortezomib44 1110.6THPO, IL6
2il 11449.6IL6, IL3
3tgf beta1449.6IL6, THPO
4mip 1alpha449.5IL6, IL3
5hyaluronic acid44 2410.5THPO, IL6
6anaphylatoxin449.5IL6, IL3
7poly(i-c)449.5IL6, IL3
8il 10449.5IL6, IL3
9ivig449.5IL3, IL6
10melphalan44 1110.5IL6, IL3
11neopterin449.5IL3, IL6
12mafosfamide449.5THPO, IL3
13amifostine44 1110.4THPO, IL3
14ifosfamide44 1110.4THPO, IL3
15leucovorin44 49 1111.4IL3, THPO
16leukotriene b444 59 2411.4IL6, IL3
17carboplatin44 49 1111.3IL3, THPO
18herbimycin a44 5910.3IL6, IL3
19hydroxyurea44 49 1111.3THPO, IL3
20cytarabine44 49 1111.3THPO, IL3
21imatinib44 49 1111.2IL3, THPO
225-aza-2deoxycytidine449.1THPO, IL3
23fmlp449.1THPO, IL3
24prostacyclin449.0IL3, THPO
25calcitriol44 59 11 2412.0IL6, IL3
26agar449.0THPO, IL3
27pixy321448.9THPO, IL6, IL3
28filgrastim44 119.9THPO, IL6, IL3
29gm-csf44 289.9IL3, IL6, THPO
30methylcellulose448.9THPO, IL6, IL3
31gp 130448.9IL3, IL6, THPO
32rantes448.9IL3, IL6, THPO
33histamine44 28 2410.9IL3, IL6, THPO
34pd 98,059448.9THPO, IL6, IL3
35ly294002448.9THPO, IL6, IL3
36actinomycin d448.9IL3, IL6, THPO
37genistein44 28 59 2 11 2413.9THPO, IL6, IL3
38lactate448.9IL3, IL6, THPO
39thymidine44 249.9THPO, IL6, IL3
40creatinine448.9IL3, IL6, THPO
41dexamethasone44 49 28 1111.9IL3, IL6, THPO
42alanine448.8THPO, IL6, IL3
43estrogen448.8THPO, IL6, IL3
44retinoic acid44 249.8IL3, IL6, THPO
455fluorouracil448.7THPO, IL3

GO Terms for genes affiliated with Cyclic Thrombocytopenia

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16Gene Ontology
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Cellular components related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5THPO, IL6, IL3

Biological processes related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.3THPO, IL6
2positive regulation of DNA replicationGO:0457409.0IL6, IL3
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8IL6, IL3

Molecular functions related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5THPO, IL6, IL3
2growth factor activityGO:0080838.2THPO, IL6, IL3

Products for genes affiliated with Cyclic Thrombocytopenia

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Sources for Cyclic Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet