MCID: CYC007
MIFTS: 33

Cyclic Thrombocytopenia malady

Rare diseases, Blood diseases categories

Summaries for Cyclic Thrombocytopenia

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MalaCards based summary: Cyclic Thrombocytopenia, also known as thrombocytopenia, cyclic, is related to thrombocytopenia and thrombocytosis, and has symptoms including autosomal dominant inheritance, thrombocytopenia and neutropenia. An important gene associated with Cyclic Thrombocytopenia is THPO (thrombopoietin), and among its related pathways are IL-9 Signaling Pathways and Jak-STAT signaling pathway. The compounds bortezomib and tgf beta1 have been mentioned in the context of this disorder. Affiliated tissues include testes and t cells, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Cyclic Thrombocytopenia

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Sources:
41NIH Rare Diseases, 43Novoseek, 60UMLS
See all sources

Cyclic Thrombocytopenia, Aliases & Descriptions:

Name: Cyclic Thrombocytopenia 41
Thrombocytopenia, Cyclic 43 60
 
Thrombocytopenia Cyclic 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Related Diseases for Cyclic Thrombocytopenia

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Graphical network of the top 20 diseases related to Cyclic Thrombocytopenia:



Diseases related to cyclic thrombocytopenia

Symptoms for Cyclic Thrombocytopenia

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HPO human phenotypes related to Cyclic Thrombocytopenia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 thrombocytopenia HP:0001873
3 neutropenia HP:0001875
4 abnormal bleeding HP:0001892

Drugs & Therapeutics for Cyclic Thrombocytopenia

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Drug clinical trials:

Search ClinicalTrials for Cyclic Thrombocytopenia

Search NIH Clinical Center for Cyclic Thrombocytopenia

Genetic Tests for Cyclic Thrombocytopenia

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Anatomical Context for Cyclic Thrombocytopenia

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MalaCards organs/tissues related to Cyclic Thrombocytopenia:

31
Testes, T cells

Animal Models for Cyclic Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Cyclic Thrombocytopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5IL6, IL3, THPO
2MP:00053978.2IL6, IL3, THPO

Publications for Cyclic Thrombocytopenia

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Articles related to Cyclic Thrombocytopenia:

(show all 36)
idTitleAuthorsYear
1
Cyclic thrombocytopenia related to menstrual cycle: a case report and literature review. (25419404)
2014
2
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. (22038676)
2012
3
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. (19484732)
2009
4
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. (19728020)
2009
5
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. (17135540)
2006
6
Human cyclic thrombocytopenia and Anaplasma spp. infection. (15654914)
2005
7
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? (15650554)
2005
8
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. (16044437)
2005
9
Idiopathic cyclic thrombocytopenia. (15572217)
2005
10
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. (15205594)
2004
11
Cyclic thrombocytopenia and polycythemia vera. (12574969)
2003
12
Clonal T cell-mediated cyclic thrombocytopenia. (12472588)
2002
13
Effective treatment of cyclic thrombocytopenia with cepharanthin. (10530079)
1999
14
Clinical manifestations of infectious canine cyclic thrombocytopenia. (9308149)
1997
15
Cyclic thrombocytopenia in a patient treated with cyclosporine for refractory idiopathic thrombocytopenic purpura. (9395191)
1997
16
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. (8757531)
1996
17
Canine infectious cyclic thrombocytopenia found in Taiwan. (8741613)
1996
18
Serum thrombopoietin levels in cyclic thrombocytopenia. (8639873)
1996
19
Megakaryopoiesis in patients with cyclic thrombocytopenia. (7577630)
1995
20
Cyclic thrombocytopenia successfully treated with low dose hormonal contraception. (7832199)
1995
21
Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. (7496073)
1995
22
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
23
Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies. (7529542)
1994
24
Periodic production of antiplatelet autoantibody directed against GPIIIa in cyclic thrombocytopenia. (8362605)
1993
25
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. (7918035)
1993
26
Cell-mediated cyclic thrombocytopenia treated with azathioprine. (2012761)
1991
27
Danazol therapy for cyclic thrombocytopenia. (2012064)
1991
28
Menstrual cyclic thrombocytopenia. (2713272)
1989
29
Cyclic thrombocytopenia of apparent autoimmune etiology. (2713494)
1989
30
Idiopathic cyclic thrombocytopenia of childhood. (2712241)
1989
31
Serologic diagnosis of infectious cyclic thrombocytopenia in dogs using an indirect fluorescent antibody test. (6362502)
1983
32
Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. (627738)
1978
33
Cyclic thrombocytopenia: a thrombopoietin deficiency? (4832304)
1974
34
Cyclic thrombocytopenia. Case report and review of literature. (4598703)
1974
35
Cyclic thrombocytopenia associated with multiple autoantibodies. (5797783)
1969
36
Cyclic thrombocytopenia of acute type. (4295269)
1967

Variations for Cyclic Thrombocytopenia

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Expression for genes affiliated with Cyclic Thrombocytopenia

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Search GEO for disease gene expression data for Cyclic Thrombocytopenia.

Pathways for genes affiliated with Cyclic Thrombocytopenia

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Pathways related to Cyclic Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.3IL6, THPO
2
Show member pathways
Type III interferon signaling36
9.1IL6, IL3
3
Show member pathways
9.1IL3, IL6
49.1IL6, IL3
59.1IL6, IL3
69.1IL6, IL3
7
Show member pathways
9.1IL6, IL3
8
Show member pathways
9.1IL6, IL3
99.1IL3, IL6
10
Show member pathways
8.5IL6, IL3, THPO
11
Show member pathways
8.5THPO, IL3, IL6
12
Show member pathways
8.5THPO, IL3, IL6
13
Show member pathways
8.5THPO, IL3, IL6
14
Show member pathways
8.5IL6, IL3, THPO
15
Show member pathways
8.5THPO, IL3, IL6
16
Show member pathways
8.5IL6, IL3, THPO
17
Show member pathways
8.5THPO, IL3, IL6
18
Show member pathways
8.5THPO, IL3, IL6
198.5IL6, IL3, THPO
20
Show member pathways
8.5THPO, IL3, IL6
21
Show member pathways
8.5IL6, IL3, THPO
22
Show member pathways
8.5IL6, IL3, THPO

Compounds for genes affiliated with Cyclic Thrombocytopenia

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Compounds related to Cyclic Thrombocytopenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1bortezomib43 49 1211.7IL6, THPO
2tgf beta1439.6THPO, IL6
3hyaluronic acid43 2410.6IL6, THPO
4il 11439.6IL3, IL6
5mip 1alpha439.6IL6, IL3
6anaphylatoxin439.5IL6, IL3
7poly(i-c)439.5IL6, IL3
8il 10439.5IL3, IL6
9ivig439.5IL6, IL3
10melphalan43 49 1211.5IL3, IL6
11neopterin439.5IL6, IL3
12mafosfamide439.5IL3, THPO
13amifostine43 1210.5THPO, IL3
14leukotriene b443 59 2411.4IL6, IL3
15ifosfamide43 1210.4THPO, IL3
16hydrocortisone43 2 59 1212.4IL6, IL3
17leucovorin43 49 1211.4THPO, IL3
18herbimycin a43 5910.4IL6, IL3
19carboplatin43 49 1211.4IL3, THPO
20hydroxyurea43 49 1211.4THPO, IL3
21cytarabine43 49 1211.3IL3, THPO
22calcitriol43 59 24 1212.3IL3, IL6
23imatinib43 49 1211.3IL3, THPO
245-aza-2deoxycytidine439.3THPO, IL3
25fmlp439.2IL3, THPO
26epinephrine43 24 1211.2IL6, THPO
27prostacyclin439.2IL3, THPO
28n acetylcysteine439.1IL6, IL3
295fluorouracil439.1IL3, THPO
30agar439.0THPO, IL3
31pixy321439.0IL6, IL3, THPO
32filgrastim43 1210.0IL6, IL3, THPO
33gm-csf43 2810.0THPO, IL3, IL6
34methylcellulose439.0IL6, IL3, THPO
35gp 130439.0IL6, IL3, THPO
36rantes438.9IL6, IL3, THPO
37histamine43 28 2410.9IL6, IL3, THPO
38pd 98,059438.9THPO, IL3, IL6
39ly294002438.9IL6, IL3, THPO
40actinomycin d438.9IL6, IL3, THPO
41genistein43 28 59 2 24 1213.9THPO, IL3, IL6
42lactate438.9IL6, IL3, THPO
43thymidine43 249.9THPO, IL3, IL6
44creatinine438.9IL6, IL3, THPO
45dexamethasone43 49 28 1211.9IL6, IL3, THPO
46alanine438.9IL6, IL3, THPO
47estrogen438.9THPO, IL3, IL6
48retinoic acid43 249.8IL6, IL3, THPO
49etoposide43 49 59 1211.7IL3, THPO
50tyrosine438.6IL6, IL3, THPO

GO Terms for genes affiliated with Cyclic Thrombocytopenia

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Cellular components related to Cyclic Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5IL6, IL3, THPO

Biological processes related to Cyclic Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase B signalingGO:00518979.3IL6, THPO
2positive regulation of DNA replicationGO:00457409.2IL6, IL3
3positive regulation of ERK1 and ERK2 cascadeGO:00703749.2THPO, IL6
4positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2IL6, IL3
5positive regulation of cell proliferationGO:00082849.1IL6, IL3
6platelet activationGO:00301689.0IL6, THPO

Molecular functions related to Cyclic Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.5IL6, IL3, THPO
2growth factor activityGO:00080838.2IL6, IL3, THPO

Products for genes affiliated with Cyclic Thrombocytopenia

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Sources for Cyclic Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet