MCID: CYC007
MIFTS: 38

Cyclic Thrombocytopenia malady

Rare diseases, Blood diseases categories

Summaries for Cyclic Thrombocytopenia

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MalaCards based summary: Cyclic Thrombocytopenia, also known as thrombocytopenia, cyclic, is related to thrombocytopenia and thrombocytosis, and has symptoms including autosomal dominant inheritance, thrombocytopenia and neutropenia. An important gene associated with Cyclic Thrombocytopenia is THPO (thrombopoietin), and among its related pathways are IL-9 Signaling Pathways and Jak-STAT signaling pathway. The compounds bortezomib and tgf beta1 have been mentioned in the context of this disorder. Affiliated tissues include testes and t cells, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Cyclic Thrombocytopenia

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Sources:
42NIH Rare Diseases, 44Novoseek, 61UMLS
See all sources

Cyclic Thrombocytopenia, Aliases & Descriptions:

Name: Cyclic Thrombocytopenia 42
Thrombocytopenia, Cyclic 44 61
 
Thrombocytopenia Cyclic 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Related Diseases for Cyclic Thrombocytopenia

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Graphical network of the top 20 diseases related to Cyclic Thrombocytopenia:



Diseases related to cyclic thrombocytopenia

Symptoms for Cyclic Thrombocytopenia

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HPO human phenotypes related to Cyclic Thrombocytopenia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 thrombocytopenia HP:0001873
3 neutropenia HP:0001875
4 abnormal bleeding HP:0001892

Drugs & Therapeutics for Cyclic Thrombocytopenia

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Drug clinical trials:

Search ClinicalTrials for Cyclic Thrombocytopenia

Search NIH Clinical Center for Cyclic Thrombocytopenia

Genetic Tests for Cyclic Thrombocytopenia

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Anatomical Context for Cyclic Thrombocytopenia

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MalaCards organs/tissues related to Cyclic Thrombocytopenia:

32
Testes, T cells

Animal Models for Cyclic Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Cyclic Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5IL6, IL3, THPO
2MP:00053978.2IL6, IL3, THPO

Publications for Cyclic Thrombocytopenia

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Articles related to Cyclic Thrombocytopenia:

(show all 36)
idTitleAuthorsYear
1
Cyclic thrombocytopenia associated with marked rebound thrombocytosis and fluctuating levels of endogenous thrombopoietin and reticulated platelets: a case report. (22038676)
2012
2
Successful treatment of cyclic thrombocytopenia with thrombopoietin-mimetic agents: a report of two patients. (19484732)
2009
3
Fluctuations in thrombopoietin, immature platelet fraction, and glycocalicin levels in a patient with cyclic thrombocytopenia. (19728020)
2009
4
Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP. (17135540)
2006
5
Human cyclic thrombocytopenia and Anaplasma spp. infection. (15654914)
2005
6
Is complete remission of cyclic thrombocytopenia related to correction of cobalamin deficiency due to H. pylori eradication? (15650554)
2005
7
Investigation of persistent hypochromic microcytosis unmasks hemoglobin Evanston [alpha 14 (A12) Try--> Arg] in a patient of cyclic thrombocytopenia preceding Takayasu's disease. (16273737)
2005
8
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. (16044437)
2005
9
Idiopathic cyclic thrombocytopenia. (15572217)
2005
10
Complete remission of cyclic thrombocytopenia after Helicobacter pylori eradication. (15205594)
2004
11
Cyclic thrombocytopenia and polycythemia vera. (12574969)
2003
12
Clonal T cell-mediated cyclic thrombocytopenia. (12472588)
2002
13
Effective treatment of cyclic thrombocytopenia with cepharanthin. (10530079)
1999
14
Clinical manifestations of infectious canine cyclic thrombocytopenia. (9308149)
1997
15
Cyclic thrombocytopenia in a patient treated with cyclosporine for refractory idiopathic thrombocytopenic purpura. (9395191)
1997
16
Cyclic change of cytokines in a patient with cyclic thrombocytopenia. (8757531)
1996
17
Canine infectious cyclic thrombocytopenia found in Taiwan. (8741613)
1996
18
Serum thrombopoietin levels in cyclic thrombocytopenia. (8639873)
1996
19
Megakaryopoiesis in patients with cyclic thrombocytopenia. (7577630)
1995
20
Cyclic thrombocytopenia successfully treated with low dose hormonal contraception. (7832199)
1995
21
Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. (7496073)
1995
22
A case of common variable immunodeficiency associated with cyclic thrombocytopenia. (7871984)
1994
23
Cyclic thrombocytopenia associated with IgM anti-GPIIb-IIIa autoantibodies. (7529542)
1994
24
Periodic production of antiplatelet autoantibody directed against GPIIIa in cyclic thrombocytopenia. (8362605)
1993
25
Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. (7918035)
1993
26
Cell-mediated cyclic thrombocytopenia treated with azathioprine. (2012761)
1991
27
Danazol therapy for cyclic thrombocytopenia. (2012064)
1991
28
Menstrual cyclic thrombocytopenia. (2713272)
1989
29
Cyclic thrombocytopenia of apparent autoimmune etiology. (2713494)
1989
30
Idiopathic cyclic thrombocytopenia of childhood. (2712241)
1989
31
Serologic diagnosis of infectious cyclic thrombocytopenia in dogs using an indirect fluorescent antibody test. (6362502)
1983
32
Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. (627738)
1978
33
Cyclic thrombocytopenia: a thrombopoietin deficiency? (4832304)
1974
34
Cyclic thrombocytopenia. Case report and review of literature. (4598703)
1974
35
Cyclic thrombocytopenia associated with multiple autoantibodies. (5797783)
1969
36
Cyclic thrombocytopenia of acute type. (4295269)
1967

Variations for Cyclic Thrombocytopenia

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Expression for genes affiliated with Cyclic Thrombocytopenia

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Expression patterns in normal tissues for genes affiliated with Cyclic Thrombocytopenia

Search GEO for disease gene expression data for Cyclic Thrombocytopenia.

Pathways for genes affiliated with Cyclic Thrombocytopenia

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Pathways related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
9.3IL6, THPO
2
Show member pathways
Type III interferon signaling37
9.1IL6, IL3
3
Show member pathways
9.1IL3, IL6
49.1IL6, IL3
59.1IL6, IL3
69.1IL6, IL3
7
Show member pathways
9.1IL6, IL3
8
Show member pathways
9.1IL6, IL3
99.1IL3, IL6
10
Show member pathways
8.5IL6, IL3, THPO
11
Show member pathways
8.5THPO, IL3, IL6
12
Show member pathways
8.5THPO, IL3, IL6
13
Show member pathways
8.5THPO, IL3, IL6
14
Show member pathways
8.5IL6, IL3, THPO
15
Show member pathways
8.5THPO, IL3, IL6
16
Show member pathways
8.5IL6, IL3, THPO
17
Show member pathways
8.5THPO, IL3, IL6
18
Show member pathways
8.5THPO, IL3, IL6
198.5IL6, IL3, THPO
20
Show member pathways
8.5THPO, IL3, IL6
21
Show member pathways
8.5IL6, IL3, THPO
22
Show member pathways
8.5IL6, IL3, THPO

Compounds for genes affiliated with Cyclic Thrombocytopenia

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Compounds related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1bortezomib44 50 1211.7IL6, THPO
2tgf beta1449.6THPO, IL6
3hyaluronic acid44 2510.6IL6, THPO
4il 11449.6IL3, IL6
5mip 1alpha449.6IL6, IL3
6anaphylatoxin449.5IL6, IL3
7poly(i-c)449.5IL6, IL3
8il 10449.5IL3, IL6
9ivig449.5IL6, IL3
10melphalan44 50 1211.5IL3, IL6
11neopterin449.5IL6, IL3
12mafosfamide449.5IL3, THPO
13amifostine44 1210.5THPO, IL3
14leukotriene b444 60 2511.4IL6, IL3
15ifosfamide44 1210.4THPO, IL3
16hydrocortisone44 3 60 1212.4IL6, IL3
17leucovorin44 50 1211.4THPO, IL3
18herbimycin a44 6010.4IL6, IL3
19carboplatin44 50 1211.4IL3, THPO
20hydroxyurea44 50 1211.4THPO, IL3
21cytarabine44 50 1211.3IL3, THPO
22calcitriol44 60 25 1212.3IL3, IL6
23imatinib44 50 1211.3IL3, THPO
245-aza-2deoxycytidine449.3THPO, IL3
25fmlp449.2IL3, THPO
26epinephrine44 25 1211.2IL6, THPO
27prostacyclin449.2IL3, THPO
28n acetylcysteine449.1IL6, IL3
295fluorouracil449.1IL3, THPO
30agar449.0THPO, IL3
31pixy321449.0IL6, IL3, THPO
32filgrastim44 1210.0IL6, IL3, THPO
33gm-csf44 2910.0THPO, IL3, IL6
34methylcellulose449.0IL6, IL3, THPO
35gp 130449.0IL6, IL3, THPO
36rantes448.9IL6, IL3, THPO
37histamine44 29 2510.9IL6, IL3, THPO
38pd 98,059448.9THPO, IL3, IL6
39ly294002448.9IL6, IL3, THPO
40actinomycin d448.9IL6, IL3, THPO
41genistein44 29 60 3 25 1213.9THPO, IL3, IL6
42lactate448.9IL6, IL3, THPO
43thymidine44 259.9THPO, IL3, IL6
44creatinine448.9IL6, IL3, THPO
45dexamethasone44 50 29 1211.9IL6, IL3, THPO
46alanine448.9IL6, IL3, THPO
47estrogen448.9THPO, IL3, IL6
48retinoic acid44 259.8IL6, IL3, THPO
49etoposide44 50 60 1211.7IL3, THPO
50tyrosine448.6IL6, IL3, THPO

GO Terms for genes affiliated with Cyclic Thrombocytopenia

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Cellular components related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5IL6, IL3, THPO

Biological processes related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase B signalingGO:0518979.3IL6, THPO
2positive regulation of DNA replicationGO:0457409.2IL6, IL3
3positive regulation of ERK1 and ERK2 cascadeGO:0703749.2THPO, IL6
4positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IL6, IL3
5positive regulation of cell proliferationGO:0082849.1IL6, IL3
6platelet activationGO:0301689.0IL6, THPO

Molecular functions related to Cyclic Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5IL6, IL3, THPO
2growth factor activityGO:0080838.2IL6, IL3, THPO

Products for genes affiliated with Cyclic Thrombocytopenia

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Sources for Cyclic Thrombocytopenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet