CVS
MCID: CYC008
MIFTS: 37

Cyclic Vomiting Syndrome (CVS) malady

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Cyclic Vomiting Syndrome

Aliases & Descriptions for Cyclic Vomiting Syndrome:

Name: Cyclic Vomiting Syndrome 50 25
Cyclical Vomiting Syndrome 25 69
Abdominal Migraine 25 69
Cvs 50 25
Familial Cyclic Vomiting Syndrome 50
Cyclical Vomiting 25
Periodic Vomiting 25

Classifications:



Summaries for Cyclic Vomiting Syndrome

NIH Rare Diseases : 50 cyclic vomiting syndrome (cvs) is a condition characterized by recurrent episodes of severe nausea and vomiting. episodes can last for hours or days. each episode is usually similar to previous ones. other symptoms may include physical exhaustion, pale skin, abdominal pain, diarrhea, headache, and/or fever. cvs can begin at any age but is most often diagnosed in children around 5 years of age. the underlying cause of cvs is not known, but children who suffer from migraines are more likely to develop cvs. treatment aims to control symptoms and may include anti-nausea drugs, sedatives, medications that suppress stomach acid, and/or antidepressants. last updated: 11/12/2014

MalaCards based summary : Cyclic Vomiting Syndrome, also known as cyclical vomiting syndrome, is related to neu-laxova syndrome1 and trisomy 2 mosaicism, and has symptoms including abdominal pain, lethargy and nausea. An important gene associated with Cyclic Vomiting Syndrome is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)), and among its related pathways/superpathways are Dilated cardiomyopathy and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Tamoxifen and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and testes.

Genetics Home Reference : 25 Cyclic vomiting syndrome is a disorder that causes recurrent episodes of nausea, vomiting, and tiredness (lethargy). This condition is diagnosed most often in young children, but it can affect people of any age.

Wikipedia : 71 Cyclic vomiting syndrome (US English) or cyclical vomiting syndrome (UK English) (CVS) is a chronic... more...

Related Diseases for Cyclic Vomiting Syndrome

Diseases related to Cyclic Vomiting Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
id Related Disease Score Top Affiliating Genes
1 neu-laxova syndrome1 10.8
2 trisomy 2 mosaicism 10.8
3 headache 10.0
4 influenza 10.0
5 haemophilus influenzae 10.0
6 mitochondrial disorders 9.8
7 encephalitis 9.8
8 japanese encephalitis 9.8
9 pituitary tumors 9.7
10 otitis media 9.7
11 adenoma 9.7
12 wernicke encephalopathy 9.7
13 encephalopathy 9.7
14 food allergy 9.7
15 ischemia 9.7
16 cerebritis 9.7
17 renal cell carcinoma 9.7
18 neuromuscular disease 9.7
19 gastroesophageal reflux 9.7
20 autoimmune hepatitis 9.7
21 neuropathy 9.7
22 hepatitis 9.7
23 meckel's diverticulum 9.7
24 sinusitis 9.7
25 irritable bowel syndrome 9.7
26 autonomic neuropathy 9.7
27 esophagitis 9.7
28 guillain-barre syndrome 9.7
29 fatty acid oxidation disorders 9.7
30 epilepsy 9.7
31 dysautonomia 9.7
32 hypertrophic pyloric stenosis 9.6
33 breast cancer 9.6
34 coronary artery disease 9.6
35 atrial fibrillation, familial, 10 9.5 HTR3A IL6 MT-TL1 RYR2
36 cytomegalic inclusion disease 9.1 HTR3A IL6 MT-TL1 RNR2 RYR2

Graphical network of the top 20 diseases related to Cyclic Vomiting Syndrome:



Diseases related to Cyclic Vomiting Syndrome

Symptoms & Phenotypes for Cyclic Vomiting Syndrome

UMLS symptoms related to Cyclic Vomiting Syndrome:


abdominal pain, lethargy, nausea, nausea and vomiting, vomiting, persistent vomiting, vomiting alone, signs and symptoms, digestive

Drugs & Therapeutics for Cyclic Vomiting Syndrome

Drugs for Cyclic Vomiting Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Haloperidol Approved Phase 4 52-86-8 3559
4
Ondansetron Approved Phase 4 99614-02-5 4595
5
Topiramate Approved Phase 4 97240-79-4 5284627
6
Enclomiphene Investigational Phase 4 15690-57-0
7
decanoic acid Experimental Phase 4 334-48-5 2969
8 Clomiphene Phase 4
9 Chelating Agents Phase 4
10 Selective Estrogen Receptor Modulators Phase 4
11 Neurotransmitter Agents Phase 4,Phase 2
12 Hormone Antagonists Phase 4
13 Hormones Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Estrogen Antagonists Phase 4
16 Estrogen Receptor Modulators Phase 4
17 Estrogens Phase 4
18 Zuclomiphene Phase 4
19 Fertility Agents Phase 4
20 Anticoagulants Phase 4
21 Antineoplastic Agents, Hormonal Phase 4
22 Bone Density Conservation Agents Phase 4
23 Calcium, Dietary Phase 4
24 Haloperidol decanoate Phase 4
25
Serotonin Phase 4 50-67-9 5202
26 Serotonin Agents Phase 4
27 Serotonin Antagonists Phase 4
28 Gastrointestinal Agents Phase 4
29 Dermatologic Agents Phase 4
30 Tranquilizing Agents Phase 4
31 Peripheral Nervous System Agents Phase 4
32 Dopamine Agents Phase 4
33 Dopamine Antagonists Phase 4
34 Anti-Anxiety Agents Phase 4
35 Antiemetics Phase 4
36 Psychotropic Drugs Phase 4
37 Antipsychotic Agents Phase 4
38 Autonomic Agents Phase 4
39 Central Nervous System Depressants Phase 4
40 Antipruritics Phase 4
41 Neuroprotective Agents Phase 4
42 Anticonvulsants Phase 4
43 Protective Agents Phase 4
44 Anti-Obesity Agents Phase 4
45 Citrate Nutraceutical Phase 4
46
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
47
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
48
Ethanol Approved 64-17-5 702
49
Metformin Approved 657-24-9 14219 4091
50
Hydroxocobalamin Approved 13422-51-0 11953898 5460373 44475014

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs Completed NCT02479256 Phase 4
2 Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Recruiting NCT03056482 Phase 4
3 Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated NCT00286988 Phase 4
4 Efficacy and Safety of Oral Rigosertib in Transfusion-dependent, Low or Int-1 or Trisomy 8 Int-2 Myelodysplastic Syndrome Completed NCT01584531 Phase 2
5 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
6 Acupuncture for Chemical Therapy Induced Nausea and Vomiting: a Cross-over Trail Completed NCT02127255
7 Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome Completed NCT00670800
8 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
9 Quality of Life And Psychological Symptoms In Children With Cyclic Vomiting Syndrome (CVS) Active, not recruiting NCT00743665
10 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea Active, not recruiting NCT00728026
11 Quality of Life (QOL), Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome Active, not recruiting NCT00728039
12 Infants Colics : Towards a Migrainous Origin ? Not yet recruiting NCT03155360
13 The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS) Withdrawn NCT00728104

Search NIH Clinical Center for Cyclic Vomiting Syndrome

Genetic Tests for Cyclic Vomiting Syndrome

Anatomical Context for Cyclic Vomiting Syndrome

MalaCards organs/tissues related to Cyclic Vomiting Syndrome:

39
Skin, Brain, Testes, Heart, Cortex

Publications for Cyclic Vomiting Syndrome

Articles related to Cyclic Vomiting Syndrome:

(show top 50) (show all 164)
id Title Authors Year
1
Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis. ( 28050780 )
2017
2
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
3
Prognosis of Cyclic Vomiting Syndrome. ( 27004140 )
2016
4
Anxiety and physiological responses to the Trier Social Stress Test for Children in adolescents with cyclic vomiting syndrome. ( 27554769 )
2016
5
Cyclic Vomiting Syndrome: An Update Illustrated by a Case Report. ( 27733950 )
2016
6
The Cyclic Vomiting Syndrome Threshold: A Framework for Understanding Pathogenesis and Predicting Successful Treatments. ( 27787513 )
2016
7
Gastric Electrical Stimulation as Potential Treatment in Drug Refractory Cyclic Vomiting Syndrome. ( 27241799 )
2016
8
Symptomatic management of a child with cyclic vomiting syndrome. ( 27530876 )
2016
9
Novel Treatments for Cyclic Vomiting Syndrome: Beyond Ondansetron and Amitriptyline. ( 27757817 )
2016
10
Cyclic Vomiting Syndrome in Infants and Children: A Clinical Follow-Up Study. ( 26861170 )
2016
11
Anesthetic Considerations for the Patient With Cyclic Vomiting Syndrome. ( 26939389 )
2016
12
Cyclic vomiting syndrome, inborn errors of metabolism, migraine variants, episodic syndromes that may be associated with migraine, and other unusual pediatric headache syndromes. ( 26790854 )
2016
13
Cyclic vomiting syndrome versus inborn errors of metabolism: A review with clinical recommendations. ( 26678622 )
2016
14
Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: a cross-comparison with migraine and healthy adults. ( 27910222 )
2016
15
Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. ( 27098832 )
2016
16
Inappropriate arginine vasopressin levels and hyponatremia associated with cyclic vomiting syndrome. ( 25759635 )
2015
17
Cyclic vomiting syndrome. ( 25638903 )
2015
18
Pediatric Emergency Update: Cyclic Vomiting Syndrome. ( 25814094 )
2015
19
OnabotulinumtoxinA Injections for the Treatment of Cyclic Vomiting Syndrome. ( 25823714 )
2015
20
A Case of Visceral Autonomic Neuropathy Complicated by Guillain-Barre Syndrome Accompanied with Cyclic Vomiting Syndrome-like Disorder in a Child. ( 26157699 )
2015
21
NextGen nuclear DNA sequencing in cyclic vomiting syndrome reveals a significant association with the stress-induced calcium channel (RYR2). ( 25925909 )
2015
22
Anxiety Measures Predict Health-Related Quality of Life in Children and Adolescents with Cyclic Vomiting Syndrome. ( 26095286 )
2015
23
Cyclic Vomiting Syndrome: A Functional Disorder. ( 26770896 )
2015
24
Pregnancy Complicated by Cyclic Vomiting Syndrome Successfully Treated With Amitriptyline. ( 25774931 )
2015
25
Combination of erythromycin and propranolol for treatment of childhood cyclic vomiting syndrome: a novel regimen. ( 26468347 )
2015
26
Type 1 diabetes complicated with uncontrollable adult cyclic vomiting syndrome: a case report. ( 26401489 )
2015
27
Challenges With Acute Care and Response to Treatment Among Adult Patients With Cyclic Vomiting Syndrome. ( 26626034 )
2015
28
Riboflavin in cyclic vomiting syndrome: efficacy in three children. ( 26226892 )
2015
29
Cyclic vomiting syndrome in multisystem mitochondrial disorder. ( 26757496 )
2015
30
Acute episode of cyclic vomiting syndrome preceded by arterial hypertension – Case presentation and review. ( 26478548 )
2015
31
Case 2: Severe headache and paroxysmal seizures in a 14-year-old boy with cyclic vomiting syndrome. ( 25838778 )
2015
32
Mitochondrial disorder caused Charles Darwin's cyclic vomiting syndrome. ( 24453499 )
2014
33
Cyclic vomiting syndrome: treatment options. ( 24862509 )
2014
34
Rapid or normal gastric emptying as new supportive criteria for diagnosing cyclic vomiting syndrome in adults. ( 25145650 )
2014
35
Short- and long-term outcomes of children with cyclic vomiting syndrome. ( 25632624 )
2014
36
Resistant cyclic vomiting syndrome successfully responding to chlorpromazine. ( 25006660 )
2014
37
A curable and probably often-overlooked cause of cyclic vomiting syndrome. ( 25149923 )
2014
38
Injectable sumatriptan for cyclic vomiting syndrome in adults: a case series. ( 25168483 )
2014
39
Meckel's Diverticulum Presents as Cyclic Vomiting Syndrome. ( 24961784 )
2014
40
An Internet survey of marijuana and hot shower use in adults with cyclic vomiting syndrome (CVS). ( 24792504 )
2014
41
An adult patient with cyclic vomiting syndrome successfully treated with oral sumatriptan. ( 24496427 )
2014
42
Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders. ( 24161560 )
2014
43
Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome. ( 25332060 )
2014
44
Approach to the diagnosis and treatment of cyclic vomiting syndrome: a large single-center experience with 106 patients. ( 24842256 )
2014
45
Use of a Once-Daily NSAID in Treatment of Cyclic Vomiting Syndrome. ( 24129856 )
2013
46
Health-related quality of life in children and adolescents with cyclic vomiting syndrome: a comparison with published data on youth with irritable bowel syndrome and organic gastrointestinal disorders. ( 23485030 )
2013
47
Cyclic vomiting syndrome: A common, underrecognized disorder. ( 24170626 )
2013
48
Cyclic vomiting syndrome in adults. ( 24234235 )
2013
49
Rapid Response to Mirtazapine in Cyclic Vomiting Syndrome Refractory to Conventional Prokinetics. ( 24360530 )
2013
50
From heave to leave: understanding cyclic vomiting syndrome. ( 24304524 )
2013

Variations for Cyclic Vomiting Syndrome

ClinVar genetic disease variations for Cyclic Vomiting Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MT-TL1 m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh37 Chromosome MT, 3243: 3243

Expression for Cyclic Vomiting Syndrome

Search GEO for disease gene expression data for Cyclic Vomiting Syndrome.

Pathways for Cyclic Vomiting Syndrome

Pathways related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 IL6 RYR2
2 11.01 HTR3A IL6 RYR2

GO Terms for Cyclic Vomiting Syndrome

Biological processes related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to caffeine GO:0031000 8.62 IL6 RYR2

Molecular functions related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 8.62 HTR3A RYR2

Sources for Cyclic Vomiting Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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