MCID: CYC008
MIFTS: 50

Cyclic Vomiting Syndrome

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Cyclic Vomiting Syndrome

MalaCards integrated aliases for Cyclic Vomiting Syndrome:

Name: Cyclic Vomiting Syndrome 53 72 49 24
Cvs 53 49 24
Cyclical Vomiting Syndrome 24 69
Abdominal Migraine 24 69
Familial Cyclic Vomiting Syndrome 49
Cyclical Vomiting 24
Periodic Vomiting 24

Characteristics:

OMIM:

53
Inheritance:
multifactorial
mitochondrial

Miscellaneous:
mean age at onset 5 years
mean age at resolution of symptoms 10 years
cyclic vomiting syndrome plus (cvs+) is characterized by additional neuromuscular and/or visceral organ manifestations (as indicated above)


HPO:

31
cyclic vomiting syndrome:
Inheritance multifactorial inheritance mitochondrial inheritance


Classifications:



Summaries for Cyclic Vomiting Syndrome

NIH Rare Diseases : 49 Cyclic vomiting syndrome (CVS) is a condition characterized by recurrent, prolonged episodes of severe nausea and vomiting. Episodes of vomiting may last hours or days. Other signs and symptoms during episodes may include intense sweating, paleness, weakness and fatigue, abdominal pain, diarrhea, fever, dizziness, and headache. Most people with CVS are symptom-free in between episodes, but some people have milder symptoms. The condition can begin at any age, but it most often begins in childhood. A subset of people with CVS also have neurologic or neuromuscular disorders; the condition in these cases is referred to as "CVS plus." The underlying cause of CVS is unknown. Data suggest there is a strong genetic component for CVS in children, involving changes (mutations) in mitochondrial DNA. Researchers believe that the condition primarily affects the brain, causing abnormalities in how the brain and gut interact. Many people with CVS report "triggers" for episodes, such as excitement, stress, infections, eating certain foods, and menstruation. People with a family history of migraines may be more likely to develop CVS. Treatment strategies for controlling symptoms may include avoiding triggers, medications to prevent or relieve nausea, tricyclic antidepressants, anti-migraine medications, and supplements called coenzyme Q-10 and L-carnitine. While some people with CVS outgrow the condition within a few years, others continue to have episodes through adulthood. Children who outgrow CVS may go on to develop migraines.  Last updated: 10/16/2017

MalaCards based summary : Cyclic Vomiting Syndrome, also known as cvs, is related to anxiety and human coronavirus sensitivity, and has symptoms including ataxia, seizures and abdominal pain. An important gene associated with Cyclic Vomiting Syndrome is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Interleukin-4 and 13 signaling. The drugs Dopamine and Haloperidol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart.

Genetics Home Reference : 24 Cyclic vomiting syndrome is a disorder that causes recurrent episodes of nausea, vomiting, and tiredness (lethargy). This condition is diagnosed most often in young children, but it can affect people of any age.

Wikipedia : 72 Cyclic vomiting syndrome (US English) or cyclical vomiting syndrome (UK English) (CVS) is a chronic... more...

Description from OMIM: 500007

Related Diseases for Cyclic Vomiting Syndrome

Diseases related to Cyclic Vomiting Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 51, show less)
# Related Disease Score Top Affiliating Genes
1 anxiety 29.5 CNR1 HTR3A
2 human coronavirus sensitivity 11.1
3 dihydropyrimidinase deficiency 11.0
4 neu-laxova syndrome 1 10.9
5 anophthalmos with limb anomalies 10.9
6 chromosome 10p duplication 10.9
7 trisomy 2 mosaicism 10.9
8 migraine with or without aura 1 10.4
9 influenza 10.2
10 haemophilus influenzae 10.2
11 chronic pain 10.2 CNR1 OPRM1
12 constipation 10.1 HTR3A OPRM1
13 amnestic disorder 10.1 CNR1 HTR3A
14 withdrawal disorder 10.1 CNR1 OPRM1
15 pain agnosia 10.1 CNR1 OPRM1
16 agnosia 10.1 CNR1 OPRM1
17 headache 10.1
18 uremic pruritus 10.1 CNR1 IL6
19 drug dependence 10.1 CNR1 OPRM1
20 japanese encephalitis 10.0
21 encephalitis 10.0
22 aging 10.0
23 specific developmental disorder 10.0 CNR1 OPRM1
24 disease of mental health 9.9 CNR1 OPRM1
25 overnutrition 9.9 CNR1 IL6
26 neuropathy 9.9
27 mitochondrial disorders 9.9
28 albinism 9.9
29 alcohol dependence 9.9 CNR1 HTR3A OPRM1
30 pertussis 9.8 IL6 OPRM1
31 substance dependence 9.8 CNR1 IL6 OPRM1
32 gastroesophageal reflux 9.8
33 renal cell carcinoma, nonpapillary 9.8
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
35 autoimmune hepatitis 9.8
36 hepatitis 9.8
37 sinusitis 9.8
38 autonomic neuropathy 9.8
39 esophagitis 9.8
40 guillain-barre syndrome 9.8
41 epilepsy 9.8
42 wernicke encephalopathy 9.8
43 food allergy 9.8
44 ischemia 9.8
45 cerebritis 9.8
46 neuromuscular disease 9.8
47 mitochondrial metabolism disease 9.8
48 irritable bowel syndrome 9.8
49 dysautonomia 9.8
50 encephalopathy 9.8
51 sudden infant death syndrome 9.3 HTR3A IL6 MT-TL1 RYR2

Graphical network of the top 20 diseases related to Cyclic Vomiting Syndrome:



Diseases related to Cyclic Vomiting Syndrome

Symptoms & Phenotypes for Cyclic Vomiting Syndrome

Symptoms via clinical synopsis from OMIM:

53
Abdomen Gastroin testinal:
abdominal pain
nausea
anorexia
gastrointestinal dysmotility (cvs+)

Skin Nails Hair Skin:
pallor

Head And Neck Head:
microcephaly (in patients with 'cvs-plus,' cvs+)

Head And Neck Eyes:
strabismus (cvs+)

Muscle Soft Tissue:
hypotonia (cvs+)
muscle weakness (cvs+)
delayed motor development (cvs+)
exercise intolerance (cvs+)

Neurologic Central Nervous System:
lethargy
vomiting, episodic
rapid onset
occurs most often during the night or early morning
peak frequency of vomiting every 10 to 15 minutes
more
Growth Other:
growth retardation

Head And Neck Ears:
hearing loss (cvs+)

Cardiovascular Heart:
cardiomyopathy (cvs+)

Neurologic Behavioral Psychiatric Manifestations:
attention deficit-hyperactivity disorder (cvs+)
autism (cvs+)
pervasive developmental disorder (cvs+)


Clinical features from OMIM:

500007

Human phenotypes related to Cyclic Vomiting Syndrome:

31 (showing 23, show less)
# Description HPO Frequency HPO Source Accession
1 ataxia 31 HP:0001251
2 seizures 31 HP:0001250
3 abdominal pain 31 HP:0002027
4 nausea 31 HP:0002018
5 vomiting 31 HP:0002013
6 muscle weakness 31 HP:0001324
7 lethargy 31 HP:0001254
8 intellectual disability 31 HP:0001249
9 hearing impairment 31 HP:0000365
10 microcephaly 31 HP:0000252
11 cognitive impairment 31 HP:0100543
12 pallor 31 HP:0000980
13 strabismus 31 HP:0000486
14 autism 31 HP:0000717
15 attention deficit hyperactivity disorder 31 HP:0007018
16 growth delay 31 HP:0001510
17 cardiomyopathy 31 HP:0001638
18 anorexia 31 HP:0002039
19 migraine 31 HP:0002076
20 motor delay 31 HP:0001270
21 exercise intolerance 31 HP:0003546
22 generalized hypotonia 31 HP:0001290
23 gastrointestinal dysmotility 31 HP:0002579

UMLS symptoms related to Cyclic Vomiting Syndrome:


signs and symptoms, digestive, abdominal pain, vomiting alone, persistent vomiting, vomiting, nausea and vomiting, nausea, lethargy

Drugs & Therapeutics for Cyclic Vomiting Syndrome

Drugs for Cyclic Vomiting Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 42, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Haloperidol Approved Phase 4 52-86-8 3559
3
Ondansetron Approved Phase 4 99614-02-5 4595
4
Topiramate Approved Phase 4 97240-79-4 5284627
5 Neurotransmitter Agents Phase 4,Phase 3
6 Psychotropic Drugs Phase 4,Phase 3
7 Anti-Anxiety Agents Phase 4
8 Antiemetics Phase 4
9 Antipruritics Phase 4,Phase 2
10 Antipsychotic Agents Phase 4
11 Autonomic Agents Phase 4
12 Central Nervous System Depressants Phase 4
13 decanoic acid Phase 4
14 Dermatologic Agents Phase 4,Phase 2
15 Dopamine Agents Phase 4
16 Dopamine Antagonists Phase 4
17 Gastrointestinal Agents Phase 4
18 Haloperidol decanoate Phase 4
19 Peripheral Nervous System Agents Phase 4,Phase 2
20
Serotonin Phase 4 50-67-9 5202
21 Serotonin Agents Phase 4
22 Serotonin Antagonists Phase 4
23 Tranquilizing Agents Phase 4
24 Anticonvulsants Phase 4
25 Anti-Obesity Agents Phase 4
26 Neuroprotective Agents Phase 4
27 Protective Agents Phase 4
28
Baclofen Approved Phase 3 1134-47-0 2284
29
Desipramine Approved, Investigational Phase 3 50-47-5 2995
30 Adrenergic Agents Phase 3
31 Antidepressive Agents Phase 3
32 Antidepressive Agents, Tricyclic Phase 3
33 Neurotransmitter Uptake Inhibitors Phase 3
34 Proton pump inhibitors Phase 3
35
Capsaicin Approved Phase 2 404-86-4 1548943
36
Pancrelipase Approved, Investigational 53608-75-6
37
Coenzyme Q10 Approved, Investigational, Nutraceutical 303-98-0 5281915
38 Micronutrients
39 Trace Elements
40 Ubiquinone
41 Vitamins
42 pancreatin

Interventional clinical trials:

(showing 13, show less)

# Name Status NCT ID Phase Drugs
1 Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Recruiting NCT03056482 Phase 4 Ondansetron 8mg;Haloperidol 0.05mg/kg;Haloperidol 0.1mg/kg
2 Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated NCT00286988 Phase 4 Topiramate
3 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
4 Topical Capsaicin for Cyclical Vomiting Recruiting NCT03223350 Phase 2 Capsaicin 0.075% Cream;Placebos
5 Analysis of Q10 Coenzyme Efficacy for Long-term Treatment of Cyclic Vomiting Syndrome in Children Completed NCT03295760 Q10 Coenzyme
6 Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea Completed NCT00728026
7 Quality of Life (QOL), Coping and Psychological Symptoms in Children and Adolescents With Cyclic Vomiting Syndrome Completed NCT00728039
8 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
9 Auricular Neurostimulation for Cyclic Vomiting Syndrome Recruiting NCT03434652
10 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
11 Infants Colics : Towards a Migrainous Origin ? Recruiting NCT03155360
12 Quality of Life And Psychological Symptoms In Children With Cyclic Vomiting Syndrome (CVS) Active, not recruiting NCT00743665
13 The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS) Withdrawn NCT00728104

Search NIH Clinical Center for Cyclic Vomiting Syndrome

Genetic Tests for Cyclic Vomiting Syndrome

Anatomical Context for Cyclic Vomiting Syndrome

MalaCards organs/tissues related to Cyclic Vomiting Syndrome:

38
Brain, Testes, Heart, Cortex

Publications for Cyclic Vomiting Syndrome

Articles related to Cyclic Vomiting Syndrome:

(showing 180, show less)
# Title Authors Year
1
Yield and Costs of Evaluating Children with Cyclic Vomiting Syndrome. ( 29373437 )
2018
2
Cyclic Vomiting Syndrome. ( 29437134 )
2018
3
Continuing Medical Education Questions: January 2018: Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 29311736 )
2018
4
Cyclic vomiting syndrome: epidemiology, diagnosis, and treatment. ( 29442203 )
2018
5
Cannabinoid hyperemesis and the cyclic vomiting syndrome in adults: recognition, diagnosis, acute and long-term treatment. ( 28400711 )
2017
6
Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial. ( 28719594 )
2017
7
Clinical Characteristics, Comorbidities and Hospital Outcomes in Hospitalizations with Cyclic Vomiting Syndrome: A Nationwide Analysis. ( 28050780 )
2017
8
Cyclic Vomiting Syndrome in Adults and Children: A Hypothesis. ( 28488756 )
2017
9
Cyclic Vomiting Syndrome: Randomized Controlled Trials Are also Needed in Adults. ( 29109491 )
2017
10
The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran. ( 29358999 )
2017
11
Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome. ( 28349993 )
2017
12
Cyclic vomiting syndrome is a prevalent and under-recognized condition in the gastroenterology outpatient clinic. ( 28745840 )
2017
13
Depression, young age, chronic marijuana use, and interepisodic symptoms predict psychological distress in patients with cyclic vomiting syndrome. ( 29152814 )
2017
14
Recurrent Gastrointestinal Disturbance: Abdominal Migraine and Cyclic Vomiting Syndrome. ( 28283964 )
2017
15
Cyclic vomiting syndrome after acute autonomic and sensory neuropathy. ( 28244649 )
2017
16
A Recurrent Theme: A Nationwide Analysis of Hospitalization for Cyclic Vomiting Syndrome. ( 28194596 )
2017
17
Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. ( 27098832 )
2016
18
Cyclic Vomiting Syndrome: An Update Illustrated by a Case Report. ( 27733950 )
2016
19
Cyclic Vomiting Syndrome in Infants and Children: A Clinical Follow-Up Study. ( 26861170 )
2016
20
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
21
Symptomatic management of a child with cyclic vomiting syndrome. ( 27530876 )
2016
22
Novel Treatments for Cyclic Vomiting Syndrome: Beyond Ondansetron and Amitriptyline. ( 27757817 )
2016
23
Anesthetic Considerations for the Patient With Cyclic Vomiting Syndrome. ( 26939389 )
2016
24
The Cyclic Vomiting Syndrome Threshold: A Framework for Understanding Pathogenesis and Predicting Successful Treatments. ( 27787513 )
2016
25
Cyclic vomiting syndrome versus inborn errors of metabolism: A review with clinical recommendations. ( 26678622 )
2016
26
Cyclic vomiting syndrome, inborn errors of metabolism, migraine variants, episodic syndromes that may be associated with migraine, and other unusual pediatric headache syndromes. ( 26790854 )
2016
27
Gastric Electrical Stimulation as Potential Treatment in Drug Refractory Cyclic Vomiting Syndrome. ( 27241799 )
2016
28
Problems in the Diagnosis of Cyclic Vomiting Syndrome in Children. ( 28461835 )
2016
29
Cyclic Vomiting Syndrome is characterized by altered functional brain connectivity of the insular cortex: a cross-comparison with migraine and healthy adults. ( 27910222 )
2016
30
Anxiety and physiological responses to the Trier Social Stress Test for Children in adolescents with cyclic vomiting syndrome. ( 27554769 )
2016
31
Prognosis of Cyclic Vomiting Syndrome. ( 27004140 )
2016
32
Pregnancy Complicated by Cyclic Vomiting Syndrome Successfully Treated With Amitriptyline. ( 25774931 )
2015
33
Riboflavin in cyclic vomiting syndrome: efficacy in three children. ( 26226892 )
2015
34
Challenges With Acute Care and Response to Treatment Among Adult Patients With Cyclic Vomiting Syndrome. ( 26626034 )
2015
35
Acute episode of cyclic vomiting syndrome preceded by arterial hypertension – Case presentation and review. ( 26478548 )
2015
36
Cyclic vomiting syndrome in multisystem mitochondrial disorder. ( 26757496 )
2015
37
NextGen nuclear DNA sequencing in cyclic vomiting syndrome reveals a significant association with the stress-induced calcium channel (RYR2). ( 25925909 )
2015
38
Inappropriate arginine vasopressin levels and hyponatremia associated with cyclic vomiting syndrome. ( 25759635 )
2015
39
Cyclic vomiting syndrome. ( 25638903 )
2015
40
Anxiety Measures Predict Health-Related Quality of Life in Children and Adolescents with Cyclic Vomiting Syndrome. ( 26095286 )
2015
41
Combination of erythromycin and propranolol for treatment of childhood cyclic vomiting syndrome: a novel regimen. ( 26468347 )
2015
42
Pediatric Emergency Update: Cyclic Vomiting Syndrome. ( 25814094 )
2015
43
Type 1 diabetes complicated with uncontrollable adult cyclic vomiting syndrome: a case report. ( 26401489 )
2015
44
A Case of Visceral Autonomic Neuropathy Complicated by Guillain-Barre Syndrome Accompanied with Cyclic Vomiting Syndrome-like Disorder in a Child. ( 26157699 )
2015
45
OnabotulinumtoxinA Injections for the Treatment of Cyclic Vomiting Syndrome. ( 25823714 )
2015
46
Cyclic Vomiting Syndrome: A Functional Disorder. ( 26770896 )
2015
47
Case 2: Severe headache and paroxysmal seizures in a 14-year-old boy with cyclic vomiting syndrome. ( 25838778 )
2015
48
A curable and probably often-overlooked cause of cyclic vomiting syndrome. ( 25149923 )
2014
49
Resistant cyclic vomiting syndrome successfully responding to chlorpromazine. ( 25006660 )
2014
50
Mitochondrial disorder caused Charles Darwin's cyclic vomiting syndrome. ( 24453499 )
2014
51
An Internet survey of marijuana and hot shower use in adults with cyclic vomiting syndrome (CVS). ( 24792504 )
2014
52
Rapid or normal gastric emptying as new supportive criteria for diagnosing cyclic vomiting syndrome in adults. ( 25145650 )
2014
53
Cyclic vomiting syndrome: treatment options. ( 24862509 )
2014
54
Meckel's Diverticulum Presents as Cyclic Vomiting Syndrome. ( 24961784 )
2014
55
Injectable sumatriptan for cyclic vomiting syndrome in adults: a case series. ( 25168483 )
2014
56
Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders. ( 24161560 )
2014
57
Approach to the diagnosis and treatment of cyclic vomiting syndrome: a large single-center experience with 106 patients. ( 24842256 )
2014
58
Quantitative pedigree analysis and mitochondrial DNA sequence variants in adults with cyclic vomiting syndrome. ( 25332060 )
2014
59
An adult patient with cyclic vomiting syndrome successfully treated with oral sumatriptan. ( 24496427 )
2014
60
Short- and long-term outcomes of children with cyclic vomiting syndrome. ( 25632624 )
2014
61
From heave to leave: understanding cyclic vomiting syndrome. ( 24304524 )
2013
62
Use of a Once-Daily NSAID in Treatment of Cyclic Vomiting Syndrome. ( 24129856 )
2013
63
Cyclic vomiting syndrome and abdominal migraine in adults and children. ( 23721241 )
2013
64
Cyclic vomiting syndrome: A common, underrecognized disorder. ( 24170626 )
2013
65
Health-related quality of life in children and adolescents with cyclic vomiting syndrome: a comparison with published data on youth with irritable bowel syndrome and organic gastrointestinal disorders. ( 23485030 )
2013
66
Cyclic vomiting syndrome masking a fatal metabolic disease. ( 23052622 )
2013
67
Rapid Response to Mirtazapine in Cyclic Vomiting Syndrome Refractory to Conventional Prokinetics. ( 24360530 )
2013
68
Cyclic vomiting syndrome in adults. ( 24234235 )
2013
69
Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult? ( 22639867 )
2012
70
Antimigraine (low-amine) diet may be helpful in children with cyclic vomiting syndrome. ( 22302150 )
2012
71
Association of marijuana use and cyclic vomiting syndrome. ( 24281708 )
2012
72
Cyclic vomiting syndrome in 28 patients: demographics, features and outcomes. ( 22617361 )
2012
73
Cyclic vomiting syndrome: case report and short review of the literature. ( 22712168 )
2012
74
The management of cyclic vomiting syndrome: a systematic review. ( 22634989 )
2012
75
Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males. ( 21951771 )
2012
76
Cyclic vomiting syndrome developed after stroke. ( 22506247 )
2012
77
Review article: cyclic vomiting syndrome in adults--rediscovering and redefining an old entity. ( 21668458 )
2011
78
Cyclic vomiting syndrome: a physiological response to a pathologic substrate? ( 21138501 )
2011
79
High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. ( 21846334 )
2011
80
Cyclic vomiting syndrome and migraine in children. ( 21741006 )
2011
81
Elevated serum ghrelin levels in adult patients with cyclic vomiting syndrome. ( 21979213 )
2011
82
Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial. ( 21147834 )
2011
83
Autonomic nerve function in adult patients with cyclic vomiting syndrome. ( 21323793 )
2011
84
Cyclic vomiting syndrome in Taiwanese children. ( 21316008 )
2011
85
Efficacy of nebivolol and amitriptyline in the prophylaxis of cyclic vomiting syndrome: a case report. ( 20827121 )
2010
86
Cyclic vomiting syndrome in an adult patient. ( 20394033 )
2010
87
Breaking the cycle: cognitive behavioral therapy and biofeedback training in a case of cyclic vomiting syndrome. ( 21154016 )
2010
88
Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study. ( 20667005 )
2010
89
Who are the nonresponders to standard treatment with tricyclic antidepressant agents for cyclic vomiting syndrome in adults? ( 19817722 )
2010
90
A survey of emergency department use in patients with cyclic vomiting syndrome. ( 20181253 )
2010
91
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. ( 20109231 )
2010
92
A case of cyclic vomiting syndrome responding to gonadotropin-releasing hormone analogue. ( 20535330 )
2010
93
Adult cyclic vomiting syndrome successfully treated with intranasal sumatriptan. ( 19911235 )
2010
94
Spectrum of gastric emptying patterns in adult patients with cyclic vomiting syndrome. ( 20723071 )
2010
95
Recent concepts on cyclic vomiting syndrome in children. ( 20535344 )
2010
96
Cyclic vomiting syndrome in a male patient with history of renal cell carcinoma status post nephrectomy. ( 22457701 )
2010
97
Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study. ( 20027010 )
2010
98
Successful treatment with sumatriptan in a case with cyclic vomiting syndrome combined with 18q- syndrome. ( 19794103 )
2009
99
Effective prophylactic therapy for cyclic vomiting syndrome in children using valproate. ( 18752910 )
2009
100
Cyclic vomiting syndrome responding to amitryptiline. ( 20012789 )
2009
101
Cyclic vomiting syndrome: what does it mean? ( 19824494 )
2009
102
The tsunami from within: cyclic vomiting syndrome in children. ( 20010236 )
2009
103
Two cases of cyclic vomiting syndrome in systemic autoimmune conditions: SLE and autoimmune hepatitis. ( 19433469 )
2009
104
A comparison of dysautonomias comorbid with cyclic vomiting syndrome and with migraine. ( 20111731 )
2009
105
Cyclic vomiting syndrome in adults: disregarding a possible epileptic component? ( 19140956 )
2009
106
Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome. ( 19220304 )
2009
107
Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A. ( 19368653 )
2009
108
Cyclic vomiting syndrome: contribution to dysphagic infant death. ( 19632059 )
2009
109
The incidence of cyclic vomiting syndrome in children: population-based study. ( 18070235 )
2008
110
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. ( 18728540 )
2008
111
Cyclic vomiting syndrome in adults. ( 18371009 )
2008
112
An adult case of cyclic vomiting syndrome successfully responding to valproic acid. ( 18458864 )
2008
113
Psychiatric symptoms in children and adolescents with cyclic vomiting syndrome and their parents. ( 18081819 )
2008
114
Cyclic vomiting syndrome: what a gastroenterologist needs to know. ( 18042112 )
2007
115
Clinical, psychiatric and manometric profile of cyclic vomiting syndrome in adults and response to tricyclic therapy. ( 17300289 )
2007
116
Zonisamide or levetiracetam for adults with cyclic vomiting syndrome: a case series. ( 17157078 )
2007
117
Treatment of cyclic vomiting syndrome. ( 17761120 )
2007
118
Cyclic vomiting syndrome in children: experience with 181 cases from southern Iran. ( 17465476 )
2007
119
Autonomic abnormalities in cyclic vomiting syndrome. ( 17325552 )
2007
120
Prevalence of cyclic vomiting syndrome in a sample of Turkish school children in an urban area. ( 17063107 )
2006
121
An oral complication in a patient with cyclic vomiting syndrome: a case report and review. ( 17134074 )
2006
122
[An adult case of cyclic vomiting syndrome in which tricyclic antidepressant was effective]. ( 17260810 )
2006
123
Cyclic vomiting syndrome plus. ( 16901417 )
2006
124
Dihydroergotamine-associated intestinal ischemia in a child with cyclic vomiting syndrome. ( 16707983 )
2006
125
Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management. ( 16368014 )
2005
126
The clinical profile of cyclic vomiting syndrome in a regional hospital, Saudi Arabia. ( 16512460 )
2005
127
Dexmedetomidine in the treatment of cyclic vomiting syndrome. ( 16029414 )
2005
128
Maternal inheritance in cyclic vomiting syndrome. ( 15643622 )
2005
129
Treatment options for cyclic vomiting syndrome. ( 16162304 )
2005
130
Cyclic vomiting syndrome: a disease in disguise. ( 15794318 )
2005
131
Relationship between cyclic vomiting syndrome and migraine. ( 16015397 )
2005
132
Underlying disorders in cyclic vomiting syndrome. ( 16327969 )
2005
133
Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome. ( 15368478 )
2004
134
Cyclic vomiting syndrome: anticipatory stress response in migraine? ( 14979896 )
2004
135
Gastric emptying time in cyclic vomiting syndrome in children. ( 15745390 )
2004
136
Cyclic vomiting syndrome: a brain-gut disorder. ( 14562585 )
2003
137
Cyclic vomiting syndrome, migraine, and epilepsy: a common underlying disorder? ( 12656714 )
2003
138
Maternal inheritance in cyclic vomiting syndrome with neuromuscular disease. ( 12884425 )
2003
139
Idiopathic cyclic vomiting syndrome associated with gastroesophageal reflux and chronic sinusitis. ( 14603890 )
2003
140
Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome. ( 12845396 )
2003
141
Cyclic vomiting syndrome in Thai children. ( 12403255 )
2002
142
L-carnitine administration reduces number of episodes in cyclic vomiting syndrome. ( 11999680 )
2002
143
Familial cyclic vomiting syndrome. ( 12230597 )
2002
144
Cyclic vomiting syndrome: age-old syndrome and new insights. ( 11332860 )
2001
145
Similarities in cyclic vomiting syndrome across age groups. ( 11280534 )
2001
146
Cyclic vomiting syndrome: in vitro nitric oxide and interleukin-6 release by esophageal and gastric mucosa. ( 11330420 )
2001
147
Cyclic vomiting syndrome triggered by nonsedated upper GI endoscopy. ( 11467688 )
2001
148
Cyclic vomiting syndrome. ( 11321409 )
2001
149
Cyclic Vomiting Syndrome. ( 11096600 )
2000
150
Cyclic vomiting syndrome and food allergy/intolerance in seven children: a possible association. ( 10834522 )
2000
151
Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder. ( 10959442 )
2000
152
Cyclic vomiting syndrome: light emerging from the black box. ( 10484788 )
1999
153
Proceedings of the 2nd International Scientific Symposium on Cyclic Vomiting Syndrome. Milwaukee, Wisconsin, USA. April 17-18, 1998. ( 10507904 )
1999
154
Consensus statement--2nd International Scientific Symposium on CVS. The Faculty of The 2nd International Scientific Symposium on Cyclic Vomiting Syndrome. ( 10490032 )
1999
155
Cyclic vomiting syndrome in adults: clinical features and response to tricyclic antidepressants. ( 10520833 )
1999
156
Cyclic vomiting syndrome: timing, targets, and treatment--a basic science perspective. ( 10490037 )
1999
157
Cyclic vomiting syndrome: role of a psychiatric inpatient unit in a general children's hospital. ( 10435661 )
1999
158
Mitochondrial fatty acid oxidation disorders and cyclic vomiting syndrome. ( 10490047 )
1999
159
Autonomic function in cyclic vomiting syndrome and classic migraine. ( 10490043 )
1999
160
Electrogastrography in cyclic vomiting syndrome. ( 10490042 )
1999
161
Psychological and social characteristics and precipitants of vomiting in children with cyclic vomiting syndrome. ( 10490034 )
1999
162
Cyclic vomiting syndrome: features to be explained by a pathophysiologic model. ( 10490033 )
1999
163
Mitochondrial disease and cyclic vomiting syndrome. ( 10490048 )
1999
164
Cyclic vomiting syndrome: the corticotropin-releasing-factor hypothesis. ( 10490044 )
1999
165
Cyclic vomiting syndrome and migraine. ( 10228283 )
1999
166
Evaluation of neurocardiac signals in pediatric patients with cyclic vomiting syndrome through power spectral analysis of heart rate variability. ( 10484804 )
1999
167
Is cyclic vomiting syndrome related to migraine? ( 10228291 )
1999
168
Precipitants and aetiology of cyclic vomiting syndrome. ( 9560033 )
1998
169
Cyclic vomiting syndrome in South-East Asian children. ( 9928652 )
1998
170
Cyclic vomiting syndrome: a paroxismal disorder of brain-gut interaction. ( 9285854 )
1997
171
Effective prophylactic therapy for cyclic vomiting syndrome in children using amitriptyline or cyproheptadine. ( 9374568 )
1997
172
Cyclic vomiting syndrome and mitochondrial DNA mutations. ( 9357417 )
1997
173
Cyclic vomiting syndrome. Introduction. ( 8708858 )
1995
174
The cyclic vomiting syndrome described. ( 8708859 )
1995
175
The relationship between cyclic vomiting syndrome and abdominal migraine. ( 8708867 )
1995
176
Differential diagnosis of cyclic vomiting syndrome. ( 8708860 )
1995
177
Prophylactic therapy in cyclic vomiting syndrome. ( 8708871 )
1995
178
Management of cyclic vomiting syndrome. ( 8708870 )
1995
179
The cyclic vomiting syndrome: a report of 71 cases and literature review. ( 8145089 )
1993
180
Cyclic vomiting syndrome: a pediatric Rorschach test. ( 8145085 )
1993

Variations for Cyclic Vomiting Syndrome

ClinVar genetic disease variations for Cyclic Vomiting Syndrome:

6 (showing 1, show less)
# Gene Variation Type Significance SNP ID Assembly Location
1 MT-TL1 m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh37 Chromosome MT, 3243: 3243

Expression for Cyclic Vomiting Syndrome

Search GEO for disease gene expression data for Cyclic Vomiting Syndrome.

Pathways for Cyclic Vomiting Syndrome

Pathways related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

(showing 3, show less)
# Super pathways Score Top Affiliating Genes
1 11.34 HTR3A IL6 RYR2
2 11.21 IL6 OPRM1
3 9.74 CNR1 RYR2

GO Terms for Cyclic Vomiting Syndrome

Cellular components related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 CNR1 HTR3A OPRM1

Biological processes related to Cyclic Vomiting Syndrome according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 excitatory postsynaptic potential GO:0060079 9.37 HTR3A OPRM1
2 sensory perception of pain GO:0019233 9.32 CNR1 OPRM1
3 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.26 CNR1 OPRM1
4 response to morphine GO:0043278 9.16 CNR1 OPRM1
5 response to ethanol GO:0045471 9.13 CNR1 HTR3A OPRM1
6 response to cocaine GO:0042220 8.8 CNR1 HTR3A OPRM1

Sources for Cyclic Vomiting Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....