Cylindromatosis malady

Wikipedia: Cylindromatosis (turban tumor syndrome), also known as CYLD, is a human gene.⁴⁴ more...

MalaCards: Cylindromatosis is related to familial cylindromatosis and pneumonia. An important gene associated with Cylindromatosis is CYLD (cylindromatosis (turban tumor syndrome)), and among its related pathways are RANK Pathway and TRAF6 mediated induction of TAK1 complex. The compounds sb 203580 and tab-2 have been mentioned in the context of this disorder. Affiliated tissues include lung and skin, and related mouse phenotypes are hematopoietic system and renal/urinary system.

cylindromatosis 7

Diseases related to cylindromatosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	familial cylindromatosis	34.5	CYLD, BAP1
2	pneumonia	24.4	TLR2, CYLD, TRAF6, MAP3K7, MAPK8, CD79A
3	cd40 deficiency	13.2	TRAF6, TRAF2
4	choroid plexus carcinoma	13.0	SMARCB1, SMARCA4
5	hypohidrotic ectodermal dysplasia	13.0	TRAF6, IKBKG, MAP3K7
6	ectodermal dysplasia	12.7	TRAF6, TRAF2, IKBKG, MAP3K7
7	retinopathy of prematurity	12.6	MAPK8, IKBKG, TRAF2
8	dental caries	12.5	CD79A, SMARCA2, SMARCA4
9	williams syndrome	12.4	SMARCA2, SMARCA4, SMARCB1, SMARCE1
10	haemophilus influenzae	12.4	TLR2, CYLD, TRAF6
11	shigellosis	12.1	CD79A, MAPK8, IKBKG
12	cockayne syndrome	11.9	SMARCA4, SMARCA2, MAPK8, UBC
13	malt lymphoma	11.9	TLR2, TRAF6, TRAF2, CD79A
14	trypanosomiasis	11.8	TLR2, TRAF6, IKBKG, MAPK8
15	chagas disease	11.8	TLR2, TRAF6, IKBKG, MAPK8
16	measles	11.7	TLR2, TRAF6, MAP3K7, CD79A
17	systemic lupus erythematosus	11.4	CD79A, MAPK8, TRAF2, TLR2
18	t-cell leukemia	11.4	CYLD, TRAF6, IKBKG, MAPK8, CD79A, UBC
19	kaposi's sarcoma	11.4	SMARCB1, SMARCA4, TRAF2, MAP3K7, MAPK8, UBC
20	fanconi's anemia	11.2	SMARCE1, SMARCB1, SMARCA4, MAPK8, CD79A, UBC
21	gingivitis	11.1	TLR2, SMARCA4, SMARCA2, MAPK8, CD79A
22	toxoplasmosis	11.1	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, CD79A
23	anemia	11.0	SMARCE1, SMARCB1, SMARCA4, MAPK8, CD79A, UBC
24	multiple myeloma	11.0	TLR2, CYLD, TRAF6, TRAF2, MAPK8, CD79A
25	herpes simplex	10.9	TLR2, IKBKG, MAPK8, CD79A, UBC
26	chronic lymphocytic leukemia	10.9	TLR2, TRAF6, TRAF2, MAP3K7, MAPK8, CD79A
27	influenza	10.8	TLR2, CYLD, TRAF6, MAPK8, CD79A, UBC
28	lymphocytic leukemia	10.8	TLR2, TRAF6, TRAF2, MAP3K7, MAPK8, CD79A
29	acute lymphoblastic leukemia	10.8	SMARCA4, TRAF6, MAPK8, CD79A, UBC
30	cystic fibrosis	10.8	TLR2, SMARCA4, MAPK8, CD79A, UBC
31	inflammatory bowel disease	10.8	TLR2, TRAF6, MAPK8, CD79A, UBC
32	sarcoma	10.7	SMARCB1, SMARCA4, SMARCA2, TRAF2, MAP3K7, MAPK8
33	crohn's disease	10.6	TLR2, TRAIP, IKBKG, MAP3K7, MAPK8, CD79A
34	myeloma	10.5	TLR2, CYLD, TRAF6, TRAF2, MAPK8, CD79A
35	hepatitis c	10.5	TLR2, TRAF6, TRAF2, IKBKG, MAPK8, CD79A
36	rheumatoid arthritis	10.4	TLR2, TRAF6, TRAF2, MAP3K7, MAPK8, CD79A
37	gonococcal synovitis	10.3	TLR2, SMARCA4, TRAF6, TRAF2, IKBKG, MAP3K7
38	fibrosis	10.3	UBC, CD79A, MAPK8, MAP3K7, SMARCA4, TLR2
39	myeloid leukemia	10.2	TLR2, SMARCB1, IKBKG, MAPK8, CD79A, UBC
40	arthritis	10.2	TLR2, TRAF6, TRAF2, MAP3K7, MAPK8, CD79A
41	cholesterol	10.1	TLR2, SMARCA4, SMARCA2, TRAF2, MAPK8, CD79A
42	melanoma	9.9	TLR2, SMARCB1, SMARCA4, SMARCA2, TRAF2, MAP3K7
43	immunodeficiency	9.7	TLR2, SMARCB1, SMARCA4, TRAF6, TRAF2, IKBKG
44	pancreatitis	9.7	TLR2, SMARCB1, SMARCA4, TRAF2, IKBKG, MAP3K7
45	hepatitis	9.4	TLR2, SMARCB1, SMARCA4, TRAF6, TRAF2, IKBKG
46	lung carcinoma	9.3	TLR2, SMARCA4, SMARCA2, TRAF6, TRAF2, IKBKG
47	prostatitis	9.3	TLR2, UBC, CD79A, MAPK8, MAP3K7, IKBKG
48	breast cancer	9.3	SMARCA4, SMARCB1, SMARCE1, TLR2, SMARCA2, TRAF6
49	neuronitis	9.0	CD79A, MAPK8, TRAF7, TRAF6, SMARCA2, SMARCA4
50	leukemia	8.7	TLR2, SMARCB1, SMARCA4, SMARCA2, CYLD, TRAF6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cylindromatosis:

²²

MGI Mouse Phenotypes related to cylindromatosis:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.2	SMARCB1, CYLD, TRAF6, IKBKG, MAP3K7
2	renal/urinary system phenotype	MP:0005367	9.0	TRAF6, SMARCA2, SMARCA4
3	muscle phenotype	MP:0005369	8.0	SMARCA4, SMARCA2, TRAF2, MAP3K7, MAPK8, TLR2
4	tumorigenesis	MP:0002006	8.0	TLR2, SMARCB1, SMARCA4, CYLD, IKBKG, MAP3K7
5	digestive/alimentary phenotype	MP:0005381	7.8	TLR2, SMARCB1, SMARCA4, SMARCA2, CYLD, IKBKG
6	integument phenotype	MP:0010771	7.7	TLR2, SMARCA4, SMARCA2, CYLD, TRAF6, IKBKG
7	liver/biliary system phenotype	MP:0005370	7.3	TLR2, SMARCB1, SMARCA4, TRAF6, IKBKG, MAP3K7
8	growth/size phenotype	MP:0005378	6.4	TLR2, SMARCB1, SMARCA2, CYLD, TRAF6, TRAIP
9	immune system phenotype	MP:0005387	6.4	CYLD, SMARCA4, SMARCB1, TLR2, TRAF6, TRAF2
10	mortality/aging	MP:0010768	6.1	CYLD, SMARCA2, SMARCA4, SMARCB1, TLR2, TRAF6
11	homeostasis/metabolism phenotype	MP:0005376	6.0	TLR2, SMARCB1, SMARCA4, SMARCA2, CYLD, TRAF6
12	cellular phenotype	MP:0005384	5.9	UBC, TLR2, SMARCB1, SMARCA4, SMARCA2, CYLD

Articles related to cylindromatosis:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	Identification of a large rearrangement in CYLD as a cause of familial cylindromatosis. (20972631)	Van den Ouweland A.M.... Houweling A.C.	2011	CYLD
2	Tumor suppressor cylindromatosis: expressed in IgA ne phropathy and negatively associated with renal tubulo-interstitial lesion. (19951577)	Sun F.... Cui T.G.	2009	CYLD, CD79A
3	Update of cylindromatosis gene (CYLD) mutations in Br ooke-Spiegler syndrome: novel insights into the role of deubiquitination in cel l signaling. (19462465)	Blake P.W.... Toro J.R.	2009	CYLD
4	Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. (19412431)	Trompouki E.... Mosialos G.	2009	CYLD
5	Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. (18332137)	Koga T.... Li J.D.	2008	MAP3K7, CYLD
6	Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells. (18245814)	Takami Y.... Kaneda Y.	2008	CYLD
7	Cylindromatosis and the CYLD gene: new lessons on the molecular principles of epithelial growth control. (18008375)	Massoumi R.... Paus R.	2007	MAPK8, CYLD
8	CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes. (16922728)	Young A.L.... Celebi J.T.	2006	CYLD
9	Cutaneous appendage tumors: familial cylindromatosis and associated tumors update. (16350444)	Lian F.... Cockerell C.J.	2005	CYLD
10	The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene. (16135788)	Wang L.... Sif S.	2005	CYLD, SMARCA4, SMARCA2
11	The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. (16230348)	Yoshida H.... Li J.D.	2005	CYLD, TLR2, TRAF6
12	Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. (15854031)	Bowen S.... Celebi J.T.	2005	CYLD
13	Aspirin against cylindromatosis? Molecular functions of the CYLD tumor suppressor (15029443)	Funk J.O.	2004	CYLD
14	Mild phenotype of familial cylindromatosis associated with an R758X nonsense mutation in the CYLD tumour suppressor gene. (15541090)	Oiso N.... Ishii M.	2004	CYLD
15	Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma. (15086550)	Zhang X.J.... Huang W.	2004	CYLD
16	Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene. (15289313)	Salhi A.... Grzeschik K.H.	2004	CYLD
17	Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. (12917690)	Brummelkamp T.R.... Bernards R.	2003	CYLD, IKBKG, TRAF2
18	Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages. (12190880)	Poblete Gutierrez P.... Frank J.	2002	CYLD
19	Identification of the familial cylindromatosis tumor suppressor gene. (10835629)	Bignell G.R.... Stratton M.R.	2000	CYLD, BAP1
20	A new hereditary cylindromatosis family associated with CYLD1 on chromosome 16. (10480375)	Thomson S.A.... Wallace M.R.	1999	CYLD
21	The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. (8649842)	Biggs P.J.... Stratton M.R.	1996	CYLD
22	Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene. (7493027)	Biggs P.J.... Stratton M.R.	1995	CYLD

Genes related to cylindromatosis according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	CYLD	cylindromatosis (turban tumor syndrome)	11.1	Summaries, Orthologs, Transcripts, Publications (show all 5 sections) Aliases & Descriptions
2	BAP1	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	11.0	Publications
3	TRAIP	TRAF interacting protein	11.0	Summaries
4	TRAF7	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	11.0	Publications
5	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	11.0	Publications
6	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	11.0	Publications
7	MAP3K7	mitogen-activated protein kinase kinase kinase 7	11.0	Publications
8	TRAF2	TNF receptor-associated factor 2	11.0	Publications
9	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	11.0	Publications
10	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	11.0	Publications
11	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.0	Publications
12	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	11.0	Publications
13	TLR2	toll-like receptor 2	11.0	Publications
14	UBC	ubiquitin C	11.0	Publications
15	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
16	MAPK8	mitogen-activated protein kinase 8	11.0	Publications

Pathways related to cylindromatosis according to GeneDecks:

(show top 50)    (show all 81)

id	Pathway	Score	Top Affiliating Genes
1	RANK Pathway36	9.7	TRAF6, IKBKG, TRAF2
2	TRAF6 mediated induction of TAK1 complex38	9.6	UBC, MAP3K7, TRAF6
3	NTHi-Induced Signaling36	9.5	MAP3K7, IKBKG, TLR2
4	TNFR2 Pathway36	9.4	MAPK8, MAP3K7, TRAF2, IKBKG
5	TNFR1 Pathway36	9.4	IKBKG, MAPK8, MAP3K7, TRAF2
6	Toll Comparative Pathway36	9.4	MAPK8, MAP3K7, TRAF6, IKBKG
7	Mucin expression in CF via IL-6, IL-17 signaling pathways41	9.4	TRAF6, MAP3K7, IKBKG, TLR2
8	TLR-TRIF Pathway36	9.4	TRAF6, MAP3K7, MAPK8
9	Chromatin Remodeling36	9.4	SMARCA4, SMARCA2, SMARCB1, SMARCE1
10	Apoptosis and survival_APRIL and BAFF signaling41	9.4	TRAF6, TRAF2, IKBKG, MAPK8
11	Apoptosis and survival APRIL and BAFF signaling10	9.4	TRAF6, IKBKG, MAPK8, TRAF2
12	Development_Ligand-dependent activation of the ESR1/AP-1 pathway41	9.4	SMARCA2, SMARCB1, SMARCE1, SMARCA4
13	Immune response_Bacterial infections in normal airways41	9.4	IKBKG, MAP3K7, TRAF6, TLR2
14	NF-KappaB Activation by EBV36	9.4	TRAF2, MAPK8, TRAF6, IKBKG
15	Development Ligand-dependent activation of the ESR1/AP-1 pathway10	9.4	SMARCB1, SMARCE1, SMARCA2, SMARCA4
16	IL-1 Pathway36	9.4	IKBKG, TRAF6, MAP3K7, MAPK8
17	Bacterial infections in CF airways41	9.4	MAP3K7, IKBKG, TRAF6, TLR2
18	Immune response IL-1 signaling pathway10	9.4	TRAF6, MAPK8, MAP3K7, IKBKG
19	TNF Signaling36	9.4	MAPK8, MAP3K7, TRAF2, IKBKG
20	NOD-like receptor signaling pathway20	9.3	MAPK8, IKBKG, TRAF6, MAP3K7
21	Transcription Ligand-dependent activation of the ESR1/SP pathway10	9.3	SMARCB1, SMARCA4, SMARCE1, SMARCA2
22	Transcription_Ligand-dependent activation of the ESR1/SP pathway41	9.3	SMARCA2, SMARCA4, SMARCB1, SMARCE1
23	NGF Pathway36	9.3	MAPK8, IKBKG, TRAF6, TRAF2
24	CD27 Pathway36	9.2	MAPK8, IKBKG, TRAF2
25	TRAIL Pathway36	9.2	IKBKG, TRAF6, TRAF2
26	Transcription_NF-kB signaling pathway41	9.2	TRAF6, IKBKG, UBC, TRAF2
27	14-3-3 Induced Apoptosis36	9.2	TRAF2, IKBKG, MAPK8, TRAF6
28	APRIL Pathway36	9.1	MAPK8, MAP3K7, IKBKG, TRAF2, TRAF6
29	CD40 Signaling36	9.1	MAP3K7, TRAF2, TRAF6, IKBKG, MAPK8
30	BAFF in B-Cell Signaling36	9.1	MAP3K7, IKBKG, TRAF2, TRAF6, MAPK8
31	RANK Signaling in Osteoclasts36	9.1	IKBKG, TRAF2, TRAF6, MAP3K7, MAPK8
32	TNF Superfamily Pathway36	9.1	TRAF2, TRAF6, IKBKG, MAPK8, MAP3K7
33	Mucin expression in CF via TLRs, EGFR signaling pathways41	9.1	MAPK8, MAP3K7, TRAF6, TLR2
34	TREM1 Pathway36	9.0	TLR2, TRAF6, MAPK8, IKBKG
35	Hepatitis C20	9.0	MAPK8, IKBKG, TRAF6, TRAF2
36	NF-KappaB Family Pathway36	8.9	MAP3K7, IKBKG, TLR2, TRAF6, TRAF2
37	RIG-I-like receptor signaling pathway20	8.9	CYLD, IKBKG, TRAF6, TRAF2, MAPK8, MAP3K7
38	NF-kappaB Signaling3	8.9	TLR2, TRAF6, CYLD, TRAF2, MAP3K7, IKBKG
39	Toll-Like Receptor Signaling Pathways37	8.9	MAP3K7, MAPK8, TLR2, TRAF6, IKBKG
40	Toll-Like Receptors Pathway36	8.9	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8
41	Osteoclast differentiation20	8.9	MAPK8, MAP3K7, IKBKG, CYLD, TRAF2, TRAF6
42	Toll-like receptor signaling pathway20	8.9	MAPK8, MAP3K7, IKBKG, TRAF6, TLR2
43	BRCA1 Pathway36	8.9	SMARCA2, SMARCA4, SMARCB1, UBC
44	Toxoplasmosis20	8.9	IKBKG, MAP3K7, MAPK8, TRAF6, TLR2
45	Chagas disease (American trypanosomiasis)20	8.9	MAPK8, TRAF6, TLR2, IKBKG
46	Immune response_IL-1 signaling pathway41	8.8	IKBKG, UBC, MAP3K7, MAPK8, TRAF6
47	MAPK signaling pathway20	8.7	TRAF6, MAPK8, TRAF2, IKBKG, MAP3K7
48	Glucocorticoid Receptor Signaling36	8.7	SMARCB1, SMARCE1, SMARCA2, MAPK8, SMARCA4
49	NF-KappaB (p50-p65) Pathway36	8.5	TRAF6, IKBKG, MAP3K7, UBC, TRAF2, TLR2
50	TRAF Pathway36	8.0	IKBKG, TRAF6, TLR2, MAP3K7, MAPK8, UBC

Compounds related to cylindromatosis according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	sb 20358032 42	10.9	MAP3K7, TRAF2
2	tab-232	9.4	MAPK8, MAP3K7, TRAF6
3	peptidoglycan32	9.4	TLR2, TRAF6, TRAF2
4	tab-132	9.1	MAPK8, MAP3K7, TRAF2, TRAF6
5	vancomycin32 9 9	11.0	CD79A, SMARCA4
6	h2o232	7.8	TLR2, TRAF6, TRAF2, MAPK8, CD79A
7	tyrosine32	7.8	SMARCA4, TRAF6, TRAF2, IKBKG, MAP3K7, MAPK8

Cellular components related to cylindromatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	CD40 receptor complex	GO:035631	9.8	TRAF2, TRAF6
2	IkappaB kinase complex	GO:008385	9.6	MAP3K7, IKBKG
3	WINAC complex	GO:071778	9.5	SMARCA2, SMARCA4
4	npBAF complex	GO:071564	9.1	SMARCA2, SMARCA4, SMARCB1, SMARCE1
5	nBAF complex	GO:071565	9.0	SMARCE1, SMARCB1, SMARCA4, SMARCA2
6	SWI/SNF complex	GO:016514	9.0	SMARCE1, SMARCB1, SMARCA4, SMARCA2

Biological processes related to cylindromatosis according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	9.9	TRAF2, CYLD
2	regulation of immunoglobulin secretion	GO:051023	9.9	TRAF2, TRAF6
3	aortic smooth muscle cell differentiation	GO:035887	9.9	SMARCA4, SMARCA2
4	positive regulation of T cell cytokine production	GO:002726	9.9	TRAF6, TRAF2, MAP3K7
5	positive regulation of interleukin-2 production	GO:032743	9.8	TRAF6, TRAF2, MAP3K7
6	positive regulation of T cell activation	GO:050870	9.8	MAP3K7, TRAF2, TRAF6
7	positive regulation of JUN kinase activity	GO:043507	9.8	TRAF6, TRAF2, MAP3K7
8	nucleosome disassembly	GO:006337	9.7	SMARCE1, SMARCB1, SMARCA4
9	activation of NF-kappaB-inducing kinase activity	GO:007250	9.6	MAP3K7, IKBKG, TRAF2, TRAF6
10	I-kappaB phosphorylation	GO:007252	9.6	MAP3K7, TLR2
11	positive regulation by host of viral transcription	GO:043923	9.4	SMARCA4, SMARCB1
12	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.3	SMARCB1, SMARCA4, TRAF6, TRAF2
13	induction of apoptosis	GO:006917	9.3	TLR2, CYLD, TRAIP, IKBKG
14	chromatin remodeling	GO:006338	9.3	SMARCE1, SMARCB1, SMARCA4, SMARCA2
15	I-kappaB kinase/NF-kappaB cascade	GO:007249	9.3	UBC, MAP3K7, IKBKG, TRAF6
16	T cell receptor signaling pathway	GO:050852	9.2	UBC, MAP3K7, IKBKG, TRAF6
17	activation of MAPK activity	GO:000187	9.2	TRAF6, IKBKG, MAP3K7, UBC
18	nucleotide-binding oligomerization domain containing signaling pathway	GO:070423	9.1	CYLD, TRAF6, IKBKG, MAP3K7, UBC
19	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.1	TRAF6, IKBKG, MAP3K7, UBC
20	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	9.1	CYLD, TRAF6, IKBKG, MAP3K7, UBC
21	regulation of transcription from RNA polymerase II promoter	GO:006357	9.0	SMARCE1, SMARCB1, SMARCA4, SMARCA2
22	induction of apoptosis by extracellular signals	GO:008624	8.9	UBC, MAPK8, TRAF2, TRAF6
23	JNK cascade	GO:007254	8.8	UBC, MAPK8, MAP3K7, IKBKG, TRAF6
24	stress-activated MAPK cascade	GO:051403	8.8	TRAF6, IKBKG, MAP3K7, MAPK8, UBC
25	MyD88-independent toll-like receptor signaling pathway	GO:002756	8.8	TRAF6, IKBKG, MAP3K7, MAPK8, UBC
26	TRIF-dependent toll-like receptor signaling pathway	GO:035666	8.8	TRAF6, IKBKG, MAP3K7, MAPK8, UBC
27	toll-like receptor 3 signaling pathway	GO:034138	8.8	UBC, MAPK8, MAP3K7, IKBKG, TRAF6
28	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.5	TLR2, TRAF6, TRAF2, IKBKG, MAP3K7, UBC
29	toll-like receptor 1 signaling pathway	GO:034130	8.3	UBC, MAPK8, MAP3K7, IKBKG, TRAF6, TLR2
30	toll-like receptor 2 signaling pathway	GO:034134	8.3	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, UBC
31	toll-like receptor signaling pathway	GO:002224	8.3	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, UBC
32	MyD88-dependent toll-like receptor signaling pathway	GO:002755	8.3	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, UBC
33	Toll signaling pathway	GO:008063	8.3	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, UBC
34	toll-like receptor 4 signaling pathway	GO:034142	8.3	TLR2, TRAF6, IKBKG, MAP3K7, MAPK8, UBC
35	apoptotic process	GO:006915	8.3	TRAF6, TRAF7, TRAF2, MAP3K7, MAPK8, UBC
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	TLR2, SMARCB1, SMARCA4, SMARCA2, TRAF6, UBC
37	innate immune response	GO:045087	7.7	TLR2, CYLD, TRAF6, TRAF2, IKBKG, MAP3K7

Molecular functions related to cylindromatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitogen-activated protein kinase kinase kinase binding	GO:031435	9.8	TRAF2, TRAF6
2	Tat protein binding	GO:030957	9.8	SMARCA4, SMARCB1
3	thioesterase binding	GO:031996	9.5	TRAF2, TRAF6
4	protein N-terminus binding	GO:047485	9.4	TRAF6, SMARCA4, SMARCE1
5	transcription coactivator activity	GO:003713	9.0	SMARCE1, SMARCB1, SMARCA4, SMARCA2
6	protein binding	GO:005515	5.2	UBC, TLR2, SMARCE1, SMARCB1, SMARCA4, SMARCA2