Cystadenoma malady

Wikipedia: Cystadenoma (or \"cystoma\") refers to a type of cystic adenoma.⁴⁴ more...

MalaCards: Cystadenoma, also known as cystadenoma (morphologic abnormality), is related to serous cystadenoma and pancreatic mucinous cystadenoma. An important gene associated with Cystadenoma is MUC16 (mucin 16, cell surface associated), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Termination of O-glycan biosynthesis. The compounds mucicarmine and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and ovary, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: Am adenoma that is a cystic.⁶

Aliases & Descriptions:

cystadenoma 6 8 32 43 cystadenoma (morphologic abnormality) 6

cystoma 6

Diseases related to cystadenoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 674)

id	Related Disease	Score	Top Affiliating Genes
1	serous cystadenoma	34.1	BRAF, FSHR, HIF1A
2	pancreatic mucinous cystadenoma	32.0	KIT, MUC5AC, MME, KRT20, PGR
3	ovarian cystadenoma	31.9	SELE, BRCA1, LMNA, CMTM5, CLDN4, CLU
4	mucinous ovarian cystadenoma	31.9	REG3A, MUC16, MUC2, CEACAM7, KRT7, KRT20
5	papillary cystadenoma	30.8	VHL, VEGFA, ARID1A, CCL25, CCBP2
6	pancreatic cystadenoma	30.7	RBM15, PAEP, CEACAM5, CEACAM3, ALDOA, AKR1A1
7	ovarian cancer	29.4	BRCA1, MUC16, CEACAM3, FSHR, INHA, CALB2
8	mucinous cystadenocarcinoma	28.4	MUC1, MUC16, CEACAM7, CEACAM3, KRT7, KRT20
9	pancreas adenocarcinoma	28.3	CNN1, SELE, INHA, ACTC1
10	neuroendocrine carcinoma	27.4	KIT, CHGA, MUC1, CEACAM5, SST, KRT7
11	epididymitis	27.3	VHL, CLDN4, CLU, CLDN3, FSHR, AR
12	adenosquamous carcinoma	27.3	CHGA, MUC1, MUC2, MUC5AC, CEACAM5, CEACAM7
13	pseudomyxoma peritonei	27.2	REG4, VIM, MUC2, MUC5AC, MUC6, CEACAM5
14	cystadenocarcinoma	27.1	PCNA, VIM, VEGFA, BCL2, MUC1, MUC16
15	von hippel-lindau disease	24.0	KIT, VIM, BRCA1, VHL, VEGFA, CLU
16	pancreatic ductal adenocarcinoma	22.2	REG3A, REG4, VIM, BRAF, VEGFA, VEGFC
17	hepatitis c	20.9	PCNA, SELE, VIM, BRAF, VEGFA, CLDN4
18	peritonitis	20.8	REG4, KIT, PCNA, SELE, VIM, BRCA1
19	pancreatitis	19.6	REG3A, REG4, CNN1, KIT, PCNA, SELE
20	endometriosis	17.8	PCNA, VIM, BRAF, BRCA1, VEGFA, VEGFC
21	ovarian carcinoma	17.6	KIT, PCNA, VIM, BRAF, BRCA1, VHL
22	adenoma	16.3	REG3A, REG4, KIT, PCNA, VIM, BRAF
23	carcinoma	16.2	REG3A, REG4, CNN1, KIT, PCNA, SELE
24	adenocarcinoma	16.2	REG3A, REG4, CNN1, KIT, PCNA, SELE
25	hepatitis	15.5	KIT, PCNA, SELE, VIM, BRAF, VHL
26	papillary serous adenocarcinoma	13.9	MUC16, KRT7, KRT20, PGR
27	endodermal sinus tumor	13.9	MUC16, CEACAM5, INHA, KRT7
28	ovarian brenner tumor	13.9	MUC16, KRT7, KRT20
29	ovarian mucinous neoplasm	13.9	MUC16, TP53, KRT7, KRT20
30	mixed epithelial stromal tumour	13.9	MME, INHA, CALB2, PGR
31	peritoneal carcinoma	13.9	BRCA1, MUC16, CEACAM5, TP53, PGR
32	papillary serous carcinoma of the peritoneum	13.9	BRCA1, MUC16, S100A1, CALB2
33	familial pancreatic cancer	13.8	BRAF, BRCA1, TP53, KRAS
34	endolymphatic sac tumor	13.8	VHL, CA9, HIF1A
35	ovarian cyst	13.8	PAEP, MUC16, CEACAM3
36	brooke-spiegler syndrome	13.8	VIM, TP53, KRT7
37	premature ovarian failure	13.8	PAEP, LGR6, FSHR, INHA
38	spitz nevus	13.8	PCNA, BRAF, TP53
39	spiradenoma	13.8	S100A1, TP53, KRT7, ACTC1
40	mixed cell type cancer	13.8	VIM, TP53, KRT7, KRT20
41	pigmented villonodular synovitis	13.8	CLU, CALB2, TP53
42	sex cord-gonadal stromal tumor	13.8	VIM, INHA, CALB2
43	malignant mixed mullerian tumor	13.8	VIM, TP53, KRT7, H19
44	pleomorphic liposarcoma	13.8	VIM, INHA, CALB2
45	pleomorphic rhabdomyosarcoma	13.8	MUC16, MME, TP53
46	ovarian mucinous adenocarcinoma	13.8	MUC2, MUC5AC, TP53, KRT7, KRT20
47	bronchogenic carcinoma	13.8	CEACAM5, CEACAM7, TP53, PSG2, PGR
48	parachordoma	13.7	VIM, MUC1, CEACAM3, KRT7, KRT20
49	ovarian mucinous cystadenocarcinoma	13.7	PCNA, VIM, MUC16, FSHR
50	osteoblastoma	13.7	VIM, MUC1, TP53

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cystadenoma:

²²

MGI Mouse Phenotypes related to cystadenoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	PGF, BRCA1
2	endocrine/exocrine gland phenotype	MP:0005379	10.2	KRAS, CA9, INHA, FSHR, LDLR, BRCA1
3	craniofacial phenotype	MP:0005382	9.6	H19, AKR1A1, KIT
4	liver/biliary system phenotype	MP:0005370	9.5	H19, HIF1A, TP53, MET, AR, VEGFA
5	embryogenesis phenotype	MP:0005380	9.2	H19, PGR, TDGF1, KRAS, MET, ARID1A
6	reproductive system phenotype	MP:0005389	8.9	KRAS, AKR1A1, CCND1, CCBP2, INHA, CD44
7	pigmentation phenotype	MP:0001186	8.7	PTEN, TP53, LDLR, BCL2, LMNA, BRCA1
8	normal phenotype	MP:0002873	8.6	CALB2, SST, KRAS, HIF1A, TDGF1, SYP
9	behavior/neurological phenotype	MP:0005386	8.5	FSHR, CD44, CALB2, PTEN, SST, PGR
10	limbs/digits/tail phenotype	MP:0005371	8.2	H19, KRAS, ESR1, MET, CD44, FSHR
11	integument phenotype	MP:0010771	8.1	MME, CCBP2, CCND1, TP53, KRAS, TGFA
12	immune system phenotype	MP:0005387	7.9	PGF, CLU, LDLR, MUC2, MUC5AC, FSHR
13	nervous system phenotype	MP:0003631	7.8	PTEN, KRAS, HIF1A, TDGF1, SYP, SLC2A1
14	hematopoietic system phenotype	MP:0005397	7.6	INHA, CCL25, CCND1, AKR1A1, KRAS, CXCL6
15	adipose tissue phenotype	MP:0005375	7.5	ESR1, TP53, PTEN, TGFA, PGF, CCL25
16	skeleton phenotype	MP:0005390	7.2	AKR1A1, ESR1, TP53, PTEN, HIF1A, TGFA
17	no phenotypic analysis	MP:0003012	7.1	H19, SLC2A1, SYP, SST, TP53, ESR1
18	renal/urinary system phenotype	MP:0005367	7.0	MET, AKR1A1, ESR1, PTEN, KRAS, HIF1A
19	mortality/aging	MP:0010768	6.5	CA9, CCND1, CCBP2, MET, FH, AKR1A1
20	vision/eye phenotype	MP:0005391	6.5	CCND1, TP53, PTEN, KRAS, HIF1A, TGFA
21	muscle phenotype	MP:0005369	6.3	MET, ESR1, TP53, PTEN, KRAS, ACTC1
22	tumorigenesis	MP:0002006	6.0	CCND1, ESR1, TP53, PTEN, KRAS, HIF1A
23	digestive/alimentary phenotype	MP:0005381	5.7	AR, INHA, MET, CCL25, CCND1, CA9
24	growth/size phenotype	MP:0005378	4.7	SST, PTEN, TP53, ESR1, CCND1, KRAS
25	cardiovascular system phenotype	MP:0005385	4.4	KIT, CD44, AREG, AR, INHA, MET
26	cellular phenotype	MP:0005384	4.4	PTEN, TP53, ESR1, AKR1A1, CCND1, MET
27	homeostasis/metabolism phenotype	MP:0005376	3.6	REG3A, MUC5AC, MT3, FSHR, CD44, MME

Articles related to cystadenoma:

(show all 48)

id	Title	Authors	Year	Affiliating Genes
1	Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. (20819672)	Cai M.Y.... Weng J.P.	2010	LMNA
2	Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors. (19391217)	Marsh W.L.... Frankel W.L.	2009	INHA, ACTC1, CNN1
3	Is serous cystadenoma of the pancreas a model of clear-cell-associated angiogenesis and tumorigenesis? (19077470)	Thirabanjasak D.... Adsay N.V.	2009	SLC2A1, CA9
4	Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. (19077459)	Cui Y.... Han J.	2009	VIM, AKR7A2
5	Immunohistochemical localization of metallothionein a nd p53 protein in pancreatic serous cystadenomas. (19578815)	SliwiA8ska-MossoA8 M.... Milnerowicz S.	2009	TP53, MT3
6	Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. (18474617)	Frew I.J.... Krek W.	2008	PTEN, VHL
7	Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study. (18208800)	Lam M.M.... Yeh M.M.	2008	MET, HGF, INHA
8	Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical study. (17457606)	Abdul-Al H.M.... Goodman Z.D.	2007	INHA, KRT7
9	Biliary cystadenoma with mesenchymal stroma (17926579)	Dubova E.A.... Shchegolev A.I.	2007	VIM
10	Role of cystic fluid in diagnosis of the pancreatic cystadenoma and cystadenocarcinoma. (18251127)	Wu H.... Ker C.G.	2007	CEACAM3
11	Serous cystadenoma of the epididymis of common epithelial ovarian type: case report with an immunohistochemical study. (17318978)	Klimis T.... Kokotas N.	2006	AR, VIM, MUC1
12	Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma. (16722930)	Handra-Luca A.... Couvelard A.	2006	MME, MUC5AC, KRT20
13	High expression of RELP (Reg IV) in neoplastic goblet cells of appendiceal mucinous cystadenoma and pseudomyxoma peritonei. (16323007)	Heiskala K.... Andersson L.C.	2006	REG4
14	Hormone-producing serous cystadenoma of the pancreas. (17167718)	Rabczynski J.... Zabel M.	2006	SST, SYP
15	Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma. (16639410)	Ylisaukko-Oja S.K.... Aaltonen L.A.	2006	FH
16	Epididymal cystadenomas and epithelial tumourlets: ef fects of VHL deficiency on the human epididymis. (16841375)	GlAosker S.... Vortmeyer A.O.	2006	VHL
17	Pure (non-papillary) serous cystadenoma of the epididymis: a histologic and immunohistochemical study. (15807314)	Pich A.... Galliano D.	2005	VIM, MUC1, CALB2
18	Mucinous cystadenoma of the pancreas with predominant stroma creating a solid tumor. (16146567)	Lee W.A.	2005	CALB2
19	Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. (15797026)	Chodankar R.... Dubeau L.	2005	BRCA1
20	Molecular genetic analysis of ovarian serous cystadenomas. (15077125)	Cheng E.J.... Shih I.e.M.	2004	BRAF, KRAS
21	Mucinous cystadenoma with mesenchymal over-growth: a new variant among pancreatic mucinous cystadenomas? (15221374)	Handra-Luca A.... Degott C.	2004	KIT
22	Immunohistochemical examination of mucinous cystadenoma of the testis. (15086841)	Naito S.... Sekine I.	2004	TP53, PGR, BCL2
23	Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. (15131356)	Menkiszak J.... LubiA8ski J.	2004	BRCA1
24	Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era. (15467680)	Koffron A.... Abecassis M.	2004	CEACAM5
25	Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary. (14571433)	Lopez J.M.... Ayala A.G.	2003	KRT7
26	Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. (12855632)	Rangel L.B.... Morin P.J.	2003	CLDN4, CLDN3
27	Hepatobiliary cystadenoma with mesenchymal stroma in a patient with chronic hepatitis C. (12858849)	Maruyama S.... Horie Y.	2003	MUC1, CEACAM3
28	Women with endometriosis have increased levels of placental growth factor in the peritoneal fluid compared with women with cystadenomas. (14645176)	Suzumori N.... Suzumori K.	2003	PGF
29	Esophagogastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas in von Hippel-Lindau disease. (14627339)	Okuyama M.... Arakawa T.	2003	HIF1A
30	Macrocystic form of serous pancreatic cystadenoma. (12385440)	Chatelain D.... FlAcjou J.F.	2002	CEACAM5
31	Cystadenomas of the liver: a spectrum of disease. (11603751)	Dixon E.... Nayak V.	2001	CEACAM5, CEACAM3
32	Macrocystic serous cystadenoma of the pancreas: clinicopathologic features in seven cases. (11185705)	Sperti C.... Pedrazzoli S.	2000	CEACAM5
33	Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women. (10854548)	Honda K.... Ogita S.	2000	LDLR
34	Serous cystadenoma of the pancreas with atypical cells. Case report. (9629514)	Fujii H.... Wakasa K.	1998	PCNA
35	Expression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymis. (9824115)	Leung S.Y.... Chung L.P.	1998	VEGFA
36	A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors. (9504865)	Wouters K.... Geboes K.	1998	PGR
37	Analysis of CD44 expression in serous and mucinous borderline tumours of the ovary: comparison with cystadenomas and overt carcinomas. (9543672)	Darai E.... Scoazec J.Y.	1998	CD44
38	Adenosquamous carcinoma arising in a mucinous cystadenoma of the pancreas. (9047255)	Campman S.C.... Ruebner B.H.	1997	MUC1, MKI67
39	Mucinous cystadenoma of the appendix with raised serum carcinoembryonic antigen concentration: clinical and pathological features. (9306947)	Shimizu T.... Matsumoto T.	1997	PSG2
40	Establishment of long-term in vitro cultures of human ovarian cystadenomas and LMP tumors and examination of their spectrum of expression of matrix-degrading proteinases. (9441775)	Luo M.P.... Dubeau L.	1997	BRCA1, LGR6
41	Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. (8786207)	Jones K.... Donner L.R.	1996	SYP
42	Mucinous biliary cystadenoma with mesenchymal stroma: expressions of CA 19-9 and carcinoembryonic antigen in serum and cystic fluid. (8887044)	Lee J.H.... Lai Y.S.	1996	CEACAM3
43	Somatic von Hippel-Lindau mutation in clear cell papillary cystadenoma of the epididymis. (8522307)	Gilcrease M.Z.... Wheeler T.M.	1995	VHL
44	Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas. (7674319)	Zheng J.... Dubeau L.	1995	TP53
45	Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. (7508878)	Ye C.... Takagi H.	1994	MUC16
46	Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. (8424699)	Lewandrowski K.B.... Warshaw A.L.	1993	CEACAM7
47	Intratesticular serous cystadenoma of borderline malignancy. A pathological, histochemical and DNA content study of a case with long-term follow-up. (8236817)	De Nictolis M.... Prat J.	1993	VIM
48	Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. (1382586)	Yuen C.T.... Feizi T.	1992	SELE

Genes related to cystadenoma according to GeneCards:

(show top 50)    (show all 75)

id	Symbol	Description	Score	GeneCards Section Context
1	MUC16	mucin 16, cell surface associated	11.0	Publications
2	BRCA1	breast cancer 1, early onset	11.0	Publications
3	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
4	KRT7	keratin 7	11.0	Publications
5	AREG	amphiregulin	11.0
6	CLU	clusterin	11.0
7	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
8	MT3	metallothionein 3	11.0	Publications
9	CLDN4	claudin 4	11.0	Publications
10	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7	11.0	Publications
11	INHA	inhibin, alpha	11.0	Publications
12	PAEP	progestagen-associated endometrial protein	11.0
13	KRT20	keratin 20	11.0	Publications
14	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
15	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
16	MME	membrane metallo-endopeptidase	11.0	Publications
17	FSHR	follicle stimulating hormone receptor	11.0
18	TGFA	transforming growth factor, alpha	11.0
19	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
20	SELE	selectin E	11.0	Publications
21	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
22	PGR	progesterone receptor	11.0	Publications
23	TP53	tumor protein p53	11.0	Publications
24	AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	11.0	Publications
25	C8G	complement component 8, gamma polypeptide	11.0
26	CNN1	calponin 1, basic, smooth muscle	11.0	Publications
27	CLDN3	claudin 3	11.0	Publications
28	REG3A	regenerating islet-derived 3 alpha	11.0
29	FH	fumarate hydratase	11.0	Publications
30	TDGF1	teratocarcinoma-derived growth factor 1	11.0
31	CCBP2	chemokine binding protein 2	11.0
32	CALB2	calbindin 2	11.0	Publications
33	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0	Publications
34	SYP	synaptophysin	11.0	Publications
35	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
36	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
37	S100A1	S100 calcium binding protein A1	11.0	Publications
38	CA9	carbonic anhydrase IX	11.0	Publications
39	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0
40	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0
41	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
42	MUC1	mucin 1, cell surface associated	11.0	Publications
43	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
44	VIM	vimentin	11.0	Publications
45	LMNA	lamin A/C	11.0	Publications
46	SST	somatostatin	11.0	Publications
47	PCNA	proliferating cell nuclear antigen	11.0	Publications
48	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
49	AR	androgen receptor	11.0	Publications
50	VEGFC	vascular endothelial growth factor C	11.0

Pathways related to cystadenoma according to GeneDecks:

(show top 50)    (show all 78)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.4	TGFA, TDGF1, HGF
2	Termination of O-glycan biosynthesis38	10.3	MUC6, MUC5AC, MUC2, MUC16, MUC1
3	14-3-3 Induced Intracellular Signaling36	10.3	PGF, TDGF1, AREG, VEGFC
4	Angiogenesis3	10.3	TDGF1, TGFA, HIF1A, CA9, VEGFC, VHL
5	Actin-Based Motility by Rho Family GTPases36	10.3	PGF, TDGF1, AREG
6	mTOR signaling pathway20	9.9	PGF, HIF1A, VEGFC, VEGFA, BRAF
7	Glioma20	9.7	TGFA, KRAS, PTEN, TP53, CCND1, BRAF
8	JNK Pathway36	9.7	PGF, TDGF1, TP53, AREG, BCL2, KIT
9	Bladder cancer20	9.7	PGF, KRAS, TP53, CCND1, VEGFC, VEGFA
10	Rac1 Pathway36	9.6	HGF, PGF, TDGF1, MET, AREG
11	Renal cell carcinoma20	9.6	VHL, FH, MET, HIF1A, TGFA, PGF
12	PPAR Pathway36	9.5	PGF, TDGF1, MET, AREG, VEGFC, KIT
13	ILK Signaling36	9.5	PGF, TDGF1, TGFA, HIF1A, MET, AREG
14	Endometrial cancer20	9.5	KRAS, PTEN, TP53, CCND1, BRAF
15	Ras Pathway36	9.5	PGF, TDGF1, TGFA, MET, AREG, VEGFC
16	Apoptotic Pathways in Synovial Fibroblasts36	9.3	HGF, PGF, TDGF1, TGFA, TP53, MET
17	Telomerase Components in Cell Signaling36	9.3	HGF, PGF, TDGF1, TGFA, TP53, MET
18	eIF2 Pathway36	9.3	HGF, PGF, TDGF1, TGFA, MET, AREG
19	Nanog in Mammalian ESC Pluripotency36	9.3	HGF, PGF, TDGF1, TGFA, MET, AREG
20	Glioma Invasiveness36	9.2	PGF, TDGF1, TGFA, AREG, CD44, VEGFC
21	Transcription Ligand-dependent activation of the ESR1/SP pathway10	9.2	HIF1A, ESR1, ARID1A, LDLR, VEGFA
22	ERK5 Signaling36	9.2	HGF, PGF, TDGF1, TGFA, MET, AREG
23	Nuclear Receptor Activation by Vitamin-A36	9.1	HGF, PGF, TDGF1, TGFA, MET, AREG
24	GPCR Pathway36	9.1	HGF, PGF, TDGF1, TGFA, MET, AREG
25	Prostate cancer20	9.1	TGFA, KRAS, PTEN, TP53, CCND1, AR
26	Melanoma20	9.0	HGF, KRAS, PTEN, TP53, CCND1, MET
27	PTEN Pathway36	9.0	HGF, PGF, TDGF1, PTEN, TP53, MET
28	ERK Signaling36	9.0	TGFA, TDGF1, CXCL6, PGF, ESR1, CCL25
29	p70S6K Signaling36	8.9	HGF, PGF, TDGF1, TGFA, MET, AREG
30	DHA Signaling36	8.7	HGF, PGF, TDGF1, TGFA, MET, AREG
31	Mitochondrial Apoptosis36	8.7	HGF, PGF, TDGF1, TGFA, TP53, MET
32	Cellular Apoptosis Pathway36	8.7	HGF, PGF, TDGF1, TGFA, TP53, MET
33	Transcription_Ligand-dependent activation of the ESR1/SP pathway41	8.7	HIF1A, ESR1, CCND1, ARID1A, LDLR, VEGFA
34	Akt Signaling36	8.6	HGF, PGF, CXCL6, TDGF1, CCND1, CCL25
35	TGF-Beta Pathway36	8.6	HGF, PGF, TDGF1, TGFA, CCL25, MET
36	eNOS Signaling36	8.5	HGF, PGF, TDGF1, TGFA, ESR1, MET
37	MAPK Family Pathway36	8.5	HGF, PGF, TDGF1, TGFA, CCL25, MET
38	MAPK Signaling36	8.5	HGF, PGF, TDGF1, TGFA, TP53, MET
39	JAK-STAT Pathway36	8.5	HGF, PGF, TDGF1, TGFA, CCL25, MET
40	IP3 Pathway36	8.5	HGF, PGF, TDGF1, TGFA, PTEN, MET
41	p53 Mediated Apoptosis36	8.4	HGF, PGF, TDGF1, TGFA, PTEN, TP53
42	PAK Pathway36	8.3	TDGF1, CXCL6, PGF, HGF, TGFA, CCL25
43	p38 Signaling36	8.2	TGFA, TDGF1, CXCL6, PGF, HGF, TP53
44	Antioxidant Action of Vitamin-C36	8.2	TDGF1, CXCL6, SLC2A1, PGF, HGF, TGFA
45	Pancreatic Adenocarcinoma36	8.1	TP53, TGFA, TDGF1, PGF, HGF, CCND1
46	Rho Family GTPases36	8.1	HGF, PGF, CXCL6, TDGF1, TGFA, CCL25
47	Focal adhesion20	8.0	HGF, PGF, PTEN, CCND1, MET, BCL2
48	Molecular Mechanisms of Cancer36	7.8	PTEN, HIF1A, TGFA, CXCL6, HGF, TP53
49	Pathways in cancer20	7.7	VEGFA, SLC2A1, HGF, TGFA, HIF1A, VEGFC
50	Estrogen Pathway36	7.4	ESR1, TGFA, TDGF1, PGF, HGF, CCND1

Compounds related to cystadenoma according to GeneDecks:

(show top 50)    (show all 230)

id	Compound	Score	Top Affiliating Genes
1	mucicarmine32	10.1	VIM, MUC1, S100A1, CEACAM5, CEACAM7, CEACAM3
2	sialic acid32	9.8	CLU, PAEP, MUC2, MUC5AC, CEACAM5, FSHR
3	gnrh32	9.7	VIM, LGR6, MT3, FSHR, MME, MKI67
4	b 72332	9.5	PCNA, VIM, CHGA, MUC1, MUC16, S100A1
5	ly29400232	9.4	SELE, VHL, VEGFA, MUC2, CD44, CCND1
6	pge232	9.1	SELE, PAEP, LDLR, MUC5AC, FSHR, MME
7	rapamycin32 42	10.1	KIT, VIM, BRAF, VHL, VEGFA, LDLR
8	glucose32	8.9	REG3A, KIT, BRAF, VHL, VEGFC, MUC16
9	crcs32	8.9	BRAF, MUC1, MUC2, CEACAM5, MME, MET
10	agar32	8.9	VIM, BRAF, BRCA1, MUC1, CEACAM5, MET
11	5-aza-2deoxycytidine32	8.5	PCNA, VIM, BRCA1, VHL, CLU, MUC2
12	ribonucleic acid32	8.5	KIT, VEGFC, CLU, PAEP, CHGA, MUC1
13	hematoxylin32	8.3	KIT, PCNA, VIM, CHGA, MUC1, MUC16
14	methotrexate32 34 42 9 9	12.1	KIT, PCNA, SELE, VIM, BRCA1, MUC1
15	butyrate32	8.1	PCNA, VIM, CLU, BCL2, MUC1, MUC2
16	etoposide32 42 9 9	10.9	PCNA, SELE, CLU, BCL2, CHGA, CD44
17	geldanamycin32 9 9	9.9	BRAF, VEGFA, AR, MET, CCND1, ESR1
18	creatinine32	7.9	PCNA, SELE, VIM, LMNA, CHGA, MUC1
19	formaldehyde32 18	8.8	KIT, PCNA, SELE, VIM, CHGA, MUC1
20	gefitinib32 34 9 9	10.7	KIT, VIM, VEGFA, CEACAM5, CEACAM7, AREG
21	folate32	7.7	SELE, VIM, BRCA1, VHL, CLU, LDLR
22	estradiol32 9 18 9	10.7	PCNA, VIM, BRCA1, VEGFC, PAEP, MUC1
23	adriamycin32	7.7	VIM, BRCA1, BCL2, MUC1, CEACAM5, CEACAM3
24	cysteine32	7.6	PCNA, BRCA1, CLU, LDLR, MUC1, MUC2
25	lactate32	7.5	KIT, PCNA, SELE, VIM, CLU, CHGA
26	matrigel32	7.5	SELE, VIM, BRAF, VEGFA, VEGFC, CLU
27	oxygen32 18	8.4	BRCA1, CLU, BCL2, MUC5AC, MT3, CEACAM3
28	oligonucleotide32	7.2	KIT, PCNA, VIM, BRAF, BRCA1, VHL
29	glycogen32 18	8.1	KIT, VIM, VHL, CHGA, MUC1, S100A1
30	thymidine32 18	8.1	REG3A, KIT, PCNA, BRCA1, VEGFC, CLU
31	steroid32	7.0	KIT, BRCA1, CLU, PAEP, LGR6, CHGA
32	dexamethasone32 42 34 9 9	11.0	PCNA, VIM, VEGFA, VEGFC, CLDN4, CLU
33	estrogen32	7.0	PCNA, BRCA1, VHL, VEGFC, CLDN4, CLU
34	phosphatidylinositol32	6.8	KIT, BRAF, VHL, VEGFC, BCL2, MUC5AC
35	5fluorouracil32	6.5	KIT, PCNA, SELE, BRCA1, VEGFA, BCL2
36	calcium32 9 18 9	9.4	REG4, KIT, BRAF, BRCA1, VHL, VEGFC
37	cisplatin32 34 9 9	9.3	PCNA, BRAF, BRCA1, VEGFA, CLU, BCL2
38	actinomycin d32	6.3	CNN1, KIT, SELE, VIM, VHL, VEGFA
39	genistein32 9 18 9	9.2	PCNA, SELE, VIM, BRCA1, VEGFA, PAEP
40	retinoic acid32 42 18	8.1	KIT, BRAF, BRCA1, VEGFC, LMNA, CLU
41	progesterone32 42 9 18 9	10.0	KIT, PCNA, BRAF, BRCA1, VEGFC, CLU
42	paclitaxel32 34 9 9	9.0	KIT, PCNA, VIM, BRAF, BRCA1, VEGFA
43	tamoxifen32 34 9 9	8.8	PCNA, SELE, VIM, BRCA1, VEGFA, CLU
44	doxorubicin32 34 9 9	8.4	KIT, SELE, VIM, BRCA1, VEGFA, CLU
45	tyrosine32	5.2	KIT, BRAF, BRCA1, VHL, VEGFA, VEGFC
46	cycloheximide32	4.9	KIT, SELE, VIM, BRCA1, VEGFA, CLU
47	testosterone32 9 18 9	7.8	KIT, PCNA, SELE, VIM, BRCA1, VEGFC
48	serine32	4.7	KIT, SELE, VIM, BRAF, BRCA1, VHL
49	paraffin32	3.5	KIT, PCNA, VIM, BRAF, BRCA1, VEGFA
50	vegf32	3.4	KIT, PCNA, SELE, VIM, BRAF, BRCA1

Cellular components related to cystadenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	9.9	MUC1, MUC16, MUC2, MUC5AC, MUC6
2	platelet alpha granule lumen	GO:031093	9.3	HGF, ALDOA, CLU, VEGFC, VEGFA
3	extracellular space	GO:005615	7.7	REG3A, HGF, C8G, PGF, CXCL6, TDGF1
4	extracellular region	GO:005576	7.5	CCL25, ALDOA, SST, PSG2, CXCL6, PGF

Biological processes related to cystadenoma according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	10.4	TP53, MUC1, BRCA1
2	cellular response to stress	GO:033554	10.4	HIF1A, KRT20, CA9, VEGFA, VHL
3	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.4	VHL, VEGFA, CA9, HIF1A
4	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.2	VEGFA, MT3, HIF1A
5	cellular response to hypoxia	GO:071456	10.2	VHL, HIF1A, TP53, CA9, MT3, LMNA
6	O-glycan processing	GO:016266	10.2	MUC6, MUC5AC, MUC2, MUC16, MUC1
7	negative regulation of neuron apoptotic process	GO:043524	9.9	TGFA, HIF1A, KRAS, MT3, BCL2, BRAF
8	platelet degranulation	GO:002576	9.8	HGF, ALDOA, CLU, VEGFC, VEGFA
9	mammary gland alveolus development	GO:060749	9.8	TGFA, CCND1, AR
10	positive regulation of nitric-oxide synthase activity	GO:051000	9.7	HIF1A, KRAS, ESR1
11	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	HGF, TDGF1, TP53, CD44, VEGFA
12	positive regulation of cell division	GO:051781	9.6	PGF, TGFA, VEGFC, VEGFA
13	activation of MAPK activity	GO:000187	9.5	HGF, TDGF1, TGFA, MET, KIT
14	positive regulation of gene expression	GO:010628	9.4	KRAS, MET, CD44, MT3, VEGFA, BRAF
15	male gonad development	GO:008584	9.3	MET, INHA, AR, FSHR, BCL2, KIT
16	positive regulation of cell proliferation	GO:008284	9.2	PGF, TDGF1, KRAS, PTEN, AR, VEGFC
17	response to hypoxia	GO:001666	9.2	VEGFA, CLDN3, BCL2, MT3, HIF1A, PGF
18	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.0	MET, CD44, BCL2, VEGFA, BRAF
19	negative regulation of apoptotic process	GO:043066	8.9	TDGF1, PTEN, TP53, AR, CD44, MT3
20	cell proliferation	GO:008283	8.8	TGFA, PTEN, TP53, MET, AR, MKI67
21	response to drug	GO:042493	8.4	PGF, TGFA, ACTC1, SST, CCND1, MET

Molecular functions related to cystadenoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	9.5	PGF, TDGF1, TGFA, INHA, VEGFC, VEGFA
2	enzyme binding	GO:019899	8.3	PGR, HIF1A, PTEN, TP53, ESR1, CCND1
3	protein heterodimerization activity	GO:046982	8.1	HGF, PGF, HIF1A, TP53, MET, INHA
4	identical protein binding	GO:042802	8.1	SLC2A1, SYP, TP53, ESR1, ALDOA, S100A1
5	protein binding	GO:005515	3.5	HGF, MME, MKI67, ARID1A, AR, INHA