MCID: CYS008
MIFTS: 74

Cystic Echinococcosis malady

Infectious diseases, Rare diseases, Respiratory diseases, Liver diseases categories
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Summaries for Cystic Echinococcosis

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Disease Ontology:8 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection of thyroid, is related to echinococcosis and paragonimiasis, and has symptoms including pruritus/itching, nausea/vomiting/regurgitation/merycism/hyperemesis and acute abdominal pain/colic. An important gene associated with Cystic Echinococcosis is MT-ATP6 (mitochondrially encoded ATP synthase 6), and among its related pathways are TRAF Pathway and Immune response IL 12 signaling pathway. The drug albendazole and the compounds solium and glucuronoxylomannan have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related mouse phenotypes are tumorigenesis and skeleton.

Aliases & Classifications for Cystic Echinococcosis

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Sources:
8Disease Ontology, 48Orphanet, 62UMLS, 27ICD9CM, 57SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Cystic Echinococcosis, Aliases & Descriptions:

Name: Cystic Echinococcosis 8 48
Echinococcus Granulosus Infection of Thyroid 8 62
Echinococcus Granulosus Infection of Lung 8 62
Echinococcus Granulosus Infection 8 62
Unilocular Echinococcosis 8 62
Hydatid Disease 48 62
Hydatidosis 48 62
Echinococcus Granulosus Infectious Disease of Thyroid 8
 
Echinococcus Granulosus Infectious Disease of Liver 8
Echinococcus Granulosus Infection, Unspecified 8
Echinococcus Granulosus Infectious Disease 8
Unspecified Echinococcus Granulosus 8
Thyroid Echinococcus Granulosus 8
Liver Echinococcus Granulosus 8
Lung Echinococcus Granulosus 8
Unilocular Hydatid Disease 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
cystic echinococcosis:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:1495
ICD9CM27 122.4
MESH via Orphanet35 D004443
SNOMED-CT57 187138004, 75006000
ICD10 via Orphanet26 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
UMLS via Orphanet63 C0013502

Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis33.1MT-CO1
2paragonimiasis30.5IGHE
3aspergillosis30.5TLR4, TLR2
4invasive aspergillosis30.4TLR4, TLR2
5helminthiasis30.4RNASE3, IGHE
6toxocariasis30.4RNASE3, IGHE
7eosinophilia29.6IGHE, IL2RA, IL10, RNASE3
8sepsis29.5IL6, IL12B, IL17A, TLR4, TLR2, IL10
9hepatitis10.7
10ankylosing spondylitis10.6HLA-B
11celiac disease10.5HLA-DQB1
12farmer's lung10.5IL2RA
13mitochondrial disorders10.4MT-ATP6, MT-CO1
14taeniasis10.4
15leber hereditary optic neuropathy10.4MT-ATP6
16atopic dermatitis10.4RNASE3, TLR2
17cysticercosis10.4
18alveolar echinococcosis10.4
19colorectal cancer10.4TAP1, TAP2
20reactive arthritis10.4TAP2, HLA-B
21leprosy10.3HLA-DRB1, TLR2
22pouchitis10.3TLR4, TLR2
23melioidosis10.3TLR4, TLR2
24multiple sclerosis 110.3HLA-DQB1, HLA-DRB1
25anisakiasis10.3IGHE, RNASE3
26autoimmune thyroiditis10.3IL2RA, IL12B, HLA-B
27neisseria meningitidis infection10.3TLR2, TLR4
28intrinsic asthma10.3RNASE3, IGHE
29allergic conjunctivitis10.3IGHE, RNASE3
30kimura disease10.2IGHE, RNASE3
31eosinophilic pneumonia10.2RNASE3, IGHE
32vogt-koyanagi-harada disease10.2HLA-DRB1, IL2RA
33asthma10.2IGHE, RNASE3
34pulmonary eosinophilia10.2RNASE3, IGHE
35sjogren's syndrome10.2TAP2, TAP1, IL2RA
36conjunctivitis10.2RNASE3, IGHE
37allergic rhinitis10.2RNASE3, IGHE
38herpes simplex10.2TLR2, HLA-B, EEF1D, IL12B
39meningitis10.2HLA-B, TLR2, IL6
40food allergy10.2RNASE3, IGHE
41immunoglobulin alpha deficiency10.2HLA-DQB1, IGHE
42vernal keratoconjunctivitis10.2RNASE3, IGHE
43keratitis10.2IL17A, TLR2, TLR4
44arthritis10.2IL17A, IL6
45mastitis10.2TLR2, TLR4
46encephalitis10.2IL17A, IL12B, TLR2, HLA-B
47gastritis10.2TLR4, TLR2, IL17A
48cervical cancer10.1TAP1, TAP2, IL17A
49otitis media10.1IGHE, RNASE3, TLR2
50synovitis10.1TLR2, IL17A, IL6

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

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Symptoms:

48 (show all 44)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • urticaria
  • hepatomegaly/liver enlargement (excluding storage disease)
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • hot flushes/sensation of cold
  • proptosis/exophthalmos
  • visual loss/blindness/amblyopia
  • dizziness
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • acute hepatic failure
  • chronic hepatic failure
  • liver/hepatic abscess
  • portal hypertension
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • hypotension
  • hydrocephaly
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • cranial hypertension
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • eosinophils anomalies/hypereosinophilia
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Cystic Echinococcosis:

(show all 37)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 urticaria typical (50%) HP:0001025
6 hepatomegaly typical (50%) HP:0002240
7 abnormality of temperature regulation typical (50%) HP:0004370
8 impaired temperature sensation typical (50%) HP:0010829
9 biliary tract neoplasm typical (50%) HP:0100574
10 hydrocephalus occasional (7.5%) HP:0000238
11 visual impairment occasional (7.5%) HP:0000505
12 proptosis occasional (7.5%) HP:0000520
13 seizures occasional (7.5%) HP:0001250
14 cirrhosis occasional (7.5%) HP:0001394
15 portal hypertension occasional (7.5%) HP:0001409
16 ascites occasional (7.5%) HP:0001541
17 splenomegaly occasional (7.5%) HP:0001744
18 abnormality of eosinophils occasional (7.5%) HP:0001879
19 esophageal varix occasional (7.5%) HP:0002040
20 migraine occasional (7.5%) HP:0002076
21 respiratory insufficiency occasional (7.5%) HP:0002093
22 abnormality of the pleura occasional (7.5%) HP:0002103
23 hemoptysis occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
25 vertigo occasional (7.5%) HP:0002321
26 increased intracranial pressure occasional (7.5%) HP:0002516
27 hypotension occasional (7.5%) HP:0002615
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
31 acute hepatic failure occasional (7.5%) HP:0006554
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 liver abscess occasional (7.5%) HP:0100523
36 chronic hepatic failure occasional (7.5%) HP:0100626
37 sepsis occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

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Drug clinical trials:

Search ClinicalTrials for Cystic Echinococcosis

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

32
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes, Skin, Spleen, T cells, Tongue

Animal Models for Cystic Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Cystic Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1TLR2, TLR4, IL10, IL12B, IL6, TAP1
2MP:00053908.1IL6, IL12B, IL10, IL17A, TLR4, TLR2
3MP:00053887.8HLA-DQB1, TLR2, TLR4, IL17A, IL10, IL12B
4MP:00053697.7HLA-DQB1, TLR2, TLR4, MT-CO1, IL10, IL6
5MP:00053817.5HLA-DQB1, TLR2, TLR4, IL2RA, IL17A, IL10
6MP:00053766.9IGHE, HLA-DQB1, TLR2, TLR4, MT-CO1, IL17A
7MP:00107686.8HLA-B, HLA-DQB1, TLR2, TLR4, IL2RA, IL17A
8MP:00053976.2TLR4, TLR2, HLA-DQB1, HLA-B, IGHE, IL2RA
9MP:00053876.0TAP2, IGHE, HLA-B, HLA-DQB1, TLR2, TLR4

Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
2
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
3
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
4
Evaluation of purified antigen fraction in the immunodiagnosis of cystic echinococcosis. (24828349)
2014
5
Detection of hydatid-specific antibodies in the serum and urine for the diagnosis of cystic echinococcosis in patients from the Kashmir Valley, India. (24429044)
2014
6
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
7
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
8
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
9
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
10
Molecular diagnosis of cystic echinococcosis in humans from central Poland. (23535071)
2013
11
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
12
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
13
Cystic echinococcosis in sheep in Sardinia. Changing pattern and present status. (22178675)
2012
14
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
15
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
16
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
17
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
18
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
19
Isolated type I pelvic cystic echinococcosis mimicking ovarian tumor. (22540100)
2011
20
Cystic echinococcosis of the pelvic bone with recurrences: a case report. (22072828)
2011
21
Programme for ultrasound diagnoses and treatment with albendazole of cystic echinococcosis in asymptomatic carriers: 10 years of follow-up of cases. (20832386)
2011
22
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
23
TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis. (20193774)
2010
24
Chemotherapy and surgery in children with cystic echinococcosis. (20574405)
2010
25
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
26
Estimating the production losses due to cystic echinococcosis in ruminants in Turkey. (19482428)
2009
27
Molecular update on cystic echinococcosis in cattle and water buffaloes of southern Italy. (18234031)
2008
28
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
29
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
30
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
31
Cardiac manifestation of cystic echinococcosis: comparison of dual-source cardio-computed tomography and cardiac magnetic resonance imaging and their impact on disease management. (17984345)
2007
32
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
33
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
34
Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis. (16218215)
2005
35
Epidemiological evaluations of the efficacy of slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and animals. (16231860)
2005
36
Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico. (15533292)
2004
37
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
38
Human cystic echinococcosis in Sardinia during the 20th century. (16044696)
2004
39
Cystic echinococcosis in the Berber of the Mid Atlas mountains, Morocco: new insights into the natural history of the disease in humans. (15257798)
2004
40
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
41
Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis. (12537630)
2002
42
Prevalence, intensity, and fertility of ovine cystic echinococcosis in the central Peruvian Andes. (11579878)
2001
43
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
44
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. (11116435)
2000
45
Editorial response: Treatment of cystic echinococcosis--improving but still limited. (10476733)
1999
46
Short report: An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus-specific DNA sequences. (9660465)
1998
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
Public health importance of cystic echinococcosis in Latin America. (9236943)
1997
49
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
50
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989

Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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Expression patterns in normal tissues for genes affiliated with Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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Pathways related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9IL12B, TLR2
29.9IL12B, IL2RA
3
Show member pathways
9.7TAP2, TAP1, HLA-B
49.5TLR2, TLR4, IL12B
59.4HLA-B, HLA-DQB1, HLA-DRB1
6
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4IL12B, IL2RA, HLA-DRB1
7
Show member pathways
9.4HLA-DQB1, TLR2, TLR4
8
Show member pathways
9.4TLR2, TLR4, IL2RA
9
Show member pathways
9.3HLA-DQB1, HLA-DRB1, IL2RA
10
Show member pathways
9.2TLR2, IL17A, IL6
119.2IL10, HLA-DRB1, HLA-DQB1
12
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.2IGHE, HLA-DQB1, HLA-DRB1
139.1IL6, TLR4, TLR2
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IL6, TLR4, TLR2
159.1IL10, IL12B, IL6
169.1IL10, IL12B, IL6
17
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.1IL12B, IL2RA, HLA-DRB1, HLA-DQB1
189.0IL2RA, IL10, TAP1, TAP2
199.0HLA-DRB1, IL2RA, IL6
208.9TLR4, IL10, IL6
218.9HLA-B, HLA-DQB1, HLA-DRB1, IL10
22
Show member pathways
8.9TLR4, IL17A, IL12B, IL6
23
Show member pathways
8.9HLA-B, HLA-DQB1, HLA-DRB1, TAP1, TAP2
248.9IL6, IL12B, TLR4, TLR2
25
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8IL6, IL12B, IL10, IL17A
268.7IL6, IL2RA, TLR4, TLR2
27
Show member pathways
Type III interferon signaling37
8.7IL6, IL12B, IL10, IL2RA
288.7TLR4, IL10, IL12B, IL6
298.6HLA-DRB1, IL10, IL12B, IL6
308.6IL6, IL10, TLR4, TLR2
31
Show member pathways
8.6TLR2, TLR4, IL17A, IL12B, IL6
32
Show member pathways
8.6HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL2RA
33
Show member pathways
8.4HLA-B, HLA-DQB1, HLA-DRB1, IL2RA, IL6
348.4HLA-B, HLA-DQB1, HLA-DRB1, IL2RA, IL6
358.4TLR2, TLR4, IL10, IL12B, IL6
36
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.4TLR2, TLR4, IL10, IL12B, IL6
378.2HLA-B, HLA-DQB1, HLA-DRB1, TLR2, TLR4, TAP1
38
Show member pathways
IL27-mediated signaling events37
8.1TLR2, TLR4, IL17A, IL10, IL12B, IL6
398.0HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL17A, IL6
40
Show member pathways
8.0TLR4, IL2RA, IL17A, IL10, IL12B, IL6
41
Show member pathways
8.0TLR2, TLR4, IL2RA, IL10, IL12B, IL6
427.6HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL10, IL12B
43
Show member pathways
7.3HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL17A, IL10
44
Show member pathways
6.9TAP1, IL6, IL12B, IL10, IL2RA, RNASE3
45
Show member pathways
6.1TAP2, HLA-B, TAP1, IL6, IL12B, IL2RA

Compounds for genes affiliated with Cystic Echinococcosis

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Compounds related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1solium4410.2MT-ATP6, HLA-B, MT-CO1
2glucuronoxylomannan449.6TLR4, TLR2, IL10
3gliadin449.4HLA-DQB1, RNASE3, IGHE
45 aminosalicylic acid449.3IL2RA, IL12B, IL10
5praziquantel44 1110.3IL10, RNASE3, IGHE
6hbd2449.3IL6, TLR2, TLR4
7poly(i-c)449.2TLR4, TLR2, IL6, IL12B
8montelukast44 50 28 1112.2IGHE, RNASE3, IL10, IL2RA
9latex449.1TLR4, IGHE, TLR2, HLA-B, RNASE3
10pentoxifylline44 1110.0IL6, IL12B, IL10, IL2RA
11polymyxin b449.0TLR2, TLR4, IL6, IL10
12ccl344 289.9IL10, TLR4, IL6, TLR2
13il-12448.8IL10, IL12B, IL6
14imiquimod44 61 28 1111.8IL10, IL12B, TLR4, TLR2, IL6
15peptidoglycan44 289.8IL6, TLR2, TLR4, IL12B, IL10
16ivig448.7IL10, IGHE, IL2RA, IL6
172,5-oligoadenylate448.7IL10, IL2RA, TLR4, IL6, HLA-B
18tacrolimus44 50 1110.7TLR2, HLA-B, TLR4, IL2RA, IL17A, IL10
19allergens448.7TLR4, HLA-DRB1, IGHE, IL10, RNASE3
20polysaccharide448.7IL2RA, RNASE3, TLR4, TLR2, HLA-B, IGHE
21h2o2448.7TLR4, TLR2, PRDX4, IL2RA, HLA-B, RNASE3
22oligonucleotide448.7RNASE3, HLA-DQB1, TAP1, TAP2, HLA-DRB1, HLA-B
23lipoteichoic acid448.6TLR4, IL10, IL12B, IL6, HLA-B, TLR2
24polyinosinic-polycytidylic acid448.6TLR4, TLR2, IL10, HLA-B, IL6, IL12B
25fibrinogen448.5RNASE3, HLA-B, IL6, TLR2, TLR4
26prednisolone44 28 1110.5IL2RA, IGHE, IL10, IL6, RNASE3
27calcitriol44 61 24 1111.5TLR4, TLR2, IL2RA, IL10, IL6
28lactate448.5RNASE3, IGHE, HLA-B, TLR4, IL6, PRDX4
29il 10448.4IL6, TLR4, IL2RA, IL10, IL12B, TLR2
30sb 20358044 619.4TLR4, IL6, IL12B, IL10, IL17A, TLR2
31n acetylcysteine448.4IL2RA, TLR4, IGHE, IL6, RNASE3
32ifn-alpha448.4TLR4, TAP1, IL2RA, IL17A, IL10, IL6
33creatinine448.3RNASE3, IGHE, IL6, IL17A, HLA-B, IL2RA
34aspartate448.3HLA-DQB1, TLR4, HLA-B, IL2RA, IGHE, IL10
35infliximab44 50 1110.2IGHE, TLR4, IL2RA, IL10, IL6, IL17A
36atp44 289.0PRDX4, MT-CO1, MT-ATP6, TAP2, HLA-DRB1, HLA-B
37endotoxin448.0TLR4, TLR2, HLA-B, RNASE3, IL12B, IL6
38cycloheximide448.0TLR2, IL10, IL6, IL12B, IGHE, TLR4
39nitric oxide44 24 1110.0IL17A, IL10, IL6, RNASE3, TLR4, TLR2
40vitamin d447.9IL6, IL12B, IGHE, TLR2, IL10, TLR4
41histamine44 28 249.9IL2RA, RNASE3, TLR4, TLR2, IGHE, IL10
42alanine447.8HLA-DRB1, TLR2, TLR4, IL6, TAP1, TAP2
43methotrexate50 44 119.7IL17A, IGHE, HLA-DRB1, TLR4, IL6, IL10
44rantes447.7IL2RA, IL10, IL17A, IL6, RNASE3, TLR4
45pge2447.6RNASE3, TLR4, IL6, IL12B, IL10, IL17A
46vegf447.5IL6, TLR4, IGHE, TLR2, RNASE3, IL2RA
47lipid447.4PRDX4, RNASE3, TLR2, HLA-B, TLR4, EEF1D
48cyclosporin a44 28 619.4IGHE, HLA-B, TLR2, TLR4, IL6, IL10
49dexamethasone44 50 28 1110.3IL6, IL10, IGHE, HLA-B, TLR2, TLR4
50tyrosine446.7HLA-DRB1, HLA-DQB1, HLA-B, TLR2, EEF1D, IL2RA

GO Terms for genes affiliated with Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:0428259.9TAP2, TAP1
2MHC class II protein complexGO:0426139.6HLA-DQB1, HLA-DRB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-B, HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:0125079.5HLA-DRB1, HLA-DQB1, HLA-B
5extracellular spaceGO:0056158.6IL6, IL12B, IL10, IL17A, PRDX4
6external side of plasma membraneGO:0098978.1IL6, IL17A, IL2RA, TLR4, TLR2, HLA-DRB1
7plasma membraneGO:0058867.5HLA-B, HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL2RA

Biological processes related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.3TAP2, TAP1
2oligopeptide transmembrane transportGO:03567210.3TAP2, TAP1
3intracellular transport of viral protein in host cellGO:01906010.3TAP2, TAP1
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP2, TAP1
5peptide transportGO:01583310.3TAP1, TAP2
6cellular response to lipoteichoic acidGO:07122310.1TLR2, TLR4
7positive regulation of macrophage cytokine productionGO:06090710.1TLR2, TLR4
8immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.0HLA-DRB1, HLA-DQB1
9positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, TLR2
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0HLA-B, TAP1, TAP2
11antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.0TAP2, TAP1, HLA-B
12positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0TLR4, TLR2
13positive regulation of osteoclast differentiationGO:04567210.0IL17A, IL12B
14detection of bacteriumGO:01604510.0HLA-B, HLA-DRB1
15humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DQB1, HLA-DRB1
16I-kappaB phosphorylationGO:00725210.0TLR2, TLR4, PRDX4
17antigen processing and presentation of peptide antigen via MHC class IGO:00247410.0TAP2, TAP1, HLA-B
18negative regulation of interleukin-17 productionGO:0327009.9IL12B, TLR4, TLR2
19positive regulation of interleukin-10 productionGO:0327339.9TLR2, TLR4, IL12B
20positive regulation of NF-kappaB import into nucleusGO:0423469.9IL12B, TLR4, TLR2
21positive regulation of interleukin-12 productionGO:0327359.9IL12B, TLR4, TLR2
22positive regulation of tumor necrosis factor productionGO:0327609.9TLR2, TLR4, IL12B
23positive regulation of inflammatory responseGO:0507299.9IL12B, TLR4, TLR2
24positive regulation of T cell mediated cytotoxicityGO:0019169.9HLA-B, IL12B, TAP1, TAP2
25positive regulation of MHC class II biosynthetic processGO:0453489.9TLR4, IL10
26negative regulation of interleukin-12 productionGO:0326959.9IL10, TLR2
27negative regulation of growth of symbiont in hostGO:0441309.8TLR2, IL10, IL12B
28inflammatory response to antigenic stimulusGO:0024379.8HLA-DRB1, IL2RA
29interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DRB1, HLA-DQB1, HLA-B
30T-helper 1 type immune responseGO:0420889.8IL12B, TLR4, HLA-DRB1
31positive regulation of interleukin-8 productionGO:0327579.7TLR4, TLR2
32positive regulation of interferon-beta productionGO:0327289.7TLR4, TLR2
33defense response to protozoanGO:0428329.7IL6, IL12B
34cellular response to lipopolysaccharideGO:0712229.7TLR4, IL10, IL12B
35defense response to Gram-negative bacteriumGO:0508299.6TLR4, IL12B, IL6
36positive regulation of activated T cell proliferationGO:0421049.6IL12B, IL2RA
37positive regulation of chemokine productionGO:0327229.6TLR2, TLR4, IL6
38positive regulation of nitric oxide biosynthetic processGO:0454299.5TLR2, TLR4, IL6
39negative regulation of T cell proliferationGO:0421309.5HLA-DRB1, IL2RA, IL10
40defense response to bacteriumGO:0427429.5TLR4, RNASE3, IL10
41positive regulation of interleukin-6 productionGO:0327559.5IL6, TLR4, TLR2
42negative regulation of interferon-gamma productionGO:0326899.5HLA-DRB1, TLR4, IL10
43negative regulation of interleukin-6 productionGO:0327159.4IL10, TLR4
44response to insulinGO:0328689.4TLR2, IL10, IL6
45positive regulation of NF-kappaB transcription factor activityGO:0510929.3IL6, TLR4, TLR2
46cytokine-mediated signaling pathwayGO:0192219.2HLA-B, HLA-DQB1, HLA-DRB1, IL6
47inflammatory responseGO:0069549.0IL6, IL10, IL17A, TLR2
48positive regulation of transcription from RNA polymerase II promoterGO:0459448.6TLR2, TLR4, IL17A, IL10, IL6
49immune responseGO:0069558.0IL17A, IGHE, HLA-B, HLA-DQB1, HLA-DRB1, TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:01519710.1TAP2, TAP1
2MHC class Ib protein bindingGO:02302910.1TAP2, TAP1
3tapasin bindingGO:04698010.1TAP2, TAP1
4oligopeptide-transporting ATPase activityGO:01542110.1TAP1, TAP2
5TAP1 bindingGO:04697810.0TAP2, TAP1
6TAP2 bindingGO:0469799.9TAP2, TAP1
7lipopolysaccharide receptor activityGO:0018759.9TLR4, TLR2
8MHC class I protein bindingGO:0422889.6TAP2, TAP1
9MHC class II receptor activityGO:0323959.6HLA-DQB1, HLA-DRB1
10peptide antigen bindingGO:0426059.5TAP2, TAP1, HLA-DRB1, HLA-B
11growth factor activityGO:0080839.1IL6, IL12B, IL10
12cytokine activityGO:0051259.0IL17A, IL10, IL12B, IL6

Products for genes affiliated with Cystic Echinococcosis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Cystic Echinococcosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet