MCID: CYS008
MIFTS: 51

Cystic Echinococcosis malady

Infectious diseases, Rare diseases, Respiratory diseases, Liver diseases categories

Aliases & Classifications for Cystic Echinococcosis

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 59SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 10 12 51
Echinococcus Granulosus Infection of Thyroid 10 65
Echinococcus Granulosus Infection of Lung 10 65
Echinococcus Granulosus Infection 10 65
Echinococcus Granulosus Infectious Disease of Thyroid 10
Echinococcus Granulosus Infectious Disease of Liver 10
Echinococcus Granulosus Infection, Unspecified 10
Echinococcus Granulosus Infectious Disease 10
Unspecified Echinococcus Granulosus 10
 
Thyroid Echinococcus Granulosus 10
Liver Echinococcus Granulosus 10
Lung Echinococcus Granulosus 10
Unilocular Hydatid Disease 10
Unilocular Echinococcosis 10
Hydatid Disease 51
Echinococcosis 65
Hydatidosis 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology10 DOID:1495
ICD9CM29 122.4
Orphanet51 400
ICD10 via Orphanet28 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
SNOMED-CT59 187138004, 75006000
MESH via Orphanet37 D004443
UMLS via Orphanet66 C0013502

Summaries for Cystic Echinococcosis

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Disease Ontology:10 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection of thyroid, is related to echinococcosis and hepatitis, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are Staphylococcus aureus infection and Cytokines and Inflammatory Response. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis11.5
2hepatitis10.8
3taeniasis10.4
4alveolar echinococcosis10.4
5cysticercosis10.4
6detrusor sphincter dyssynergia10.2HLA-DRB1, MT-CO1
7microsomia hemifacial radial defects10.2HLA-DRB1, IL10
8maculopapular lupus rash10.2HLA-DRB1, IL10
9acute endometritis10.2HLA-DRB1, IL10
10interstitial keratitis10.2HLA-DRB1, IL10
11moderately severe hemophilia a10.2HLA-DRB1, IL10
12cytoplasmic body myopathy10.2HLA-DRB1, IL10
13choroid disease10.2CD40LG, HLA-DRB1
14fascioliasis10.2
15cerebellar astrocytoma10.2CD40LG, HLA-DRB1
16gastric leiomyoma10.2CES1, MT-CO1
17orthostatic proteinuria10.2CD40LG, MT-CO1
18galactosemia10.2
19liver disease10.2
20spastic diplegia10.2
21cerebritis10.2
22parasitic helminthiasis infectious disease10.2
23peritonitis10.2
24thyroiditis10.2
25acute generalized exanthematous pustulosis10.2
26spinal polio10.2CD40LG, IL10
27t cell deficiency10.2CD40LG, HLA-DRB1
28morgagni cataract10.2CD40LG, MT-CO1
29early myoclonic encephalopathy10.1CD40LG, IL10
30non-syndromic x-linked intellectual disability10.1HLA-DRB1, IL10
31aspergillosis10.1
32horner's syndrome10.1
33polycystic echinococcosis10.1
34sarcoma10.1
35finnish upper limb-onset distal myopathy10.1HLA-DRB1, IL17A
36melas syndrome10.1CD40LG, IL10
37prion disease10.1CD40LG, IL10
38hemorrhoid10.1CD40LG, HLA-DRB1
39colitis10.1CD40LG, IL10
40triple-receptor negative breast cancer10.1CD40LG, IL10
41tyrosinemia10.1CD40LG, IL10
42epiphora due to insufficient drainage10.1CD40LG, IL10
43nasopharyngitis10.1CD40LG, IL10
44breast fibroadenosis10.1CD40LG, IL10
45refractory hairy cell leukemia10.1CD40LG, IL10
46limited scleroderma10.1HLA-DRB1, IL17A
47blastomycosis10.1CD40LG, IL10
48neutropenia10.1HLA-DRB1, IL17A
49transient neonatal neutropenia10.1CD40LG, IL10
50infant gynecomastia10.1MT-ATP6, MT-CO1

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

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Symptoms:

 51 (show all 44)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • urticaria
  • hepatomegaly/liver enlargement (excluding storage disease)
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • hot flushes/sensation of cold
  • proptosis/exophthalmos
  • visual loss/blindness/amblyopia
  • dizziness
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • acute hepatic failure
  • chronic hepatic failure
  • liver/hepatic abscess
  • portal hypertension
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • hypotension
  • hydrocephaly
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • cranial hypertension
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • eosinophils anomalies/hypereosinophilia
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Cystic Echinococcosis:

(show all 37)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 urticaria typical (50%) HP:0001025
6 hepatomegaly typical (50%) HP:0002240
7 abnormality of temperature regulation typical (50%) HP:0004370
8 impaired temperature sensation typical (50%) HP:0010829
9 biliary tract neoplasm typical (50%) HP:0100574
10 hydrocephalus occasional (7.5%) HP:0000238
11 visual impairment occasional (7.5%) HP:0000505
12 proptosis occasional (7.5%) HP:0000520
13 seizures occasional (7.5%) HP:0001250
14 cirrhosis occasional (7.5%) HP:0001394
15 portal hypertension occasional (7.5%) HP:0001409
16 ascites occasional (7.5%) HP:0001541
17 splenomegaly occasional (7.5%) HP:0001744
18 abnormality of eosinophils occasional (7.5%) HP:0001879
19 esophageal varix occasional (7.5%) HP:0002040
20 migraine occasional (7.5%) HP:0002076
21 respiratory insufficiency occasional (7.5%) HP:0002093
22 abnormality of the pleura occasional (7.5%) HP:0002103
23 hemoptysis occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
25 vertigo occasional (7.5%) HP:0002321
26 increased intracranial pressure occasional (7.5%) HP:0002516
27 hypotension occasional (7.5%) HP:0002615
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
31 acute hepatic failure occasional (7.5%) HP:0006554
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 liver abscess occasional (7.5%) HP:0100523
36 chronic hepatic failure occasional (7.5%) HP:0100626
37 sepsis occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:

Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

33
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes

Animal Models for Cystic Echinococcosis or affiliated genes

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Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 435)
idTitleAuthorsYear
1
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
2
Development of a cutaneous fistula following hepatic cystic echinococcosis. (26413444)
2015
3
Knowledge, attitude, and practices (KAP) and risk factors analysis related to cystic echinococcosis among residents in Tibetan communities, Xiahe County, Gansu Province, China. (25757370)
2015
4
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis. (25566682)
2015
5
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
6
Laparoscopic approach for total cystectomy in treating hepatic cystic echinococcosis. (25489977)
2014
7
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
8
Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum. (25706429)
2014
9
Evaluation of purified antigen fraction in the immunodiagnosis of cystic echinococcosis. (24828349)
2014
10
Detection of hydatid-specific antibodies in the serum and urine for the diagnosis of cystic echinococcosis in patients from the Kashmir Valley, India. (24429044)
2014
11
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
12
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
13
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
14
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
15
Molecular diagnosis of cystic echinococcosis in humans from central Poland. (23535071)
2013
16
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
17
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
18
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
19
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
20
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
21
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
22
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
23
Isolated type I pelvic cystic echinococcosis mimicking ovarian tumor. (22540100)
2011
24
Cystic echinococcosis of the pelvic bone with recurrences: a case report. (22072828)
2011
25
Programme for ultrasound diagnoses and treatment with albendazole of cystic echinococcosis in asymptomatic carriers: 10 years of follow-up of cases. (20832386)
2011
26
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
27
TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis. (20193774)
2010
28
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
29
Estimating the production losses due to cystic echinococcosis in ruminants in Turkey. (19482428)
2009
30
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
31
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
32
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
33
Cardiac manifestation of cystic echinococcosis: comparison of dual-source cardio-computed tomography and cardiac magnetic resonance imaging and their impact on disease management. (17984345)
2007
34
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
35
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
36
Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis. (16218215)
2005
37
Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico. (15533292)
2004
38
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
39
Human cystic echinococcosis in Sardinia during the 20th century. (16044696)
2004
40
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
41
Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis. (12537630)
2002
42
Prevalence, intensity, and fertility of ovine cystic echinococcosis in the central Peruvian Andes. (11579878)
2001
43
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
44
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. (11116435)
2000
45
Editorial response: Treatment of cystic echinococcosis--improving but still limited. (10476733)
1999
46
Short report: An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus-specific DNA sequences. (9660465)
1998
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
Public health importance of cystic echinococcosis in Latin America. (9236943)
1997
49
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
50
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989

Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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GO Terms for genes affiliated with Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD40LG, HLA-DRB1, IL17A

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interferon-gamma productionGO:003268910.2HLA-DRB1, IL10
2negative regulation of T cell proliferationGO:004213010.1HLA-DRB1, IL10
3B cell proliferationGO:004210010.0CD40LG, IL10
4agingGO:00075689.4IL10, MT-ATP6, MT-CO1
5respiratory electron transport chainGO:00229049.1MT-ATP6, MT-CO1, MT-ND1
6cellular metabolic processGO:00442379.1MT-ATP6, MT-CO1, MT-ND1
7immune responseGO:00069558.6CD40LG, HLA-DRB1, IL10, IL17A

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1CD40LG, IL10, IL17A

Sources for Cystic Echinococcosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet