MCID: CYS008
MIFTS: 50

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 40MESH via Orphanet, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 11 54 13
Echinococcus Granulosus Infection 11 68
Echinococcus Granulosus Infectious Disease of Thyroid 11
Echinococcus Granulosus Infectious Disease of Liver 11
Echinococcus Granulosus Infection, Unspecified 11
Echinococcus Granulosus Infection of Thyroid 11
Echinococcus Granulosus Infectious Disease 11
Echinococcus Granulosus Infection of Lung 11
Unspecified Echinococcus Granulosus 11
 
Thyroid Echinococcus Granulosus 11
Liver Echinococcus Granulosus 11
Lung Echinococcus Granulosus 11
Unilocular Hydatid Disease 11
Unilocular Echinococcosis 11
Hydatid Disease 54
Echinococcosis 68
Hydatidosis 54

Characteristics:

Orphanet epidemiological data:

54
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:1495
ICD9CM32 122.4
Orphanet54 ORPHA400
SNOMED-CT62 187138004, 75006000
MESH via Orphanet40 D004443
UMLS via Orphanet69 C0013502
ICD10 via Orphanet31 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more

Summaries for Cystic Echinococcosis

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Disease Ontology:11 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to echinococcosis and ovarian papillary cystadenoma, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are IL-10 Pathway and African trypanosomiasis. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis11.7
2ovarian papillary cystadenoma10.5HLA-DRB1, IL10
3arachnoiditis10.5HLA-DRB1, MT-CO1
4hypertrophic or verrucous lupus erythematosus10.5HLA-DRB1, IL10
5thelaziasis10.5IL10, MT-ATP6
6panuveitis10.5HLA-DRB1, IL10
7peripheral t-cell lymphoma10.5HLA-DRB1, IL10
8hernia of ovary and fallopian tube10.5HLA-DRB1, IL10
9nebulin-related early-onset distal myopathy10.5HLA-DRB1, IL17A
10orbit alveolar rhabdomyosarcoma10.5HLA-DRB1, IL10
11lipodermatosclerosis10.5HLA-DRB1, IL10
12chronic polyneuropathy10.5HLA-DRB1, IL17A
13idiopathic central precocious puberty10.5HLA-DRB1, IL10
14sensorineural hearing loss10.5HLA-DRB1, IL10
15epididymo-orchitis10.5IL10, IL17A
16congenital nystagmus10.5CD40LG, MT-CO1
17balkan hemorrhagic fever10.4CD40LG, IL10
18kaposi sarcoma10.4HLA-DRB1, IL6
19epstein-barr virus hepatitis10.4HLA-DRB1, IL6
20abdominal chemodectomas with cutaneous angiolipomas10.4HLA-DRB1, IL6
21gastric leiomyoma10.4CES1, MT-CO1
22lymphocytic colitis10.4HLA-DRB1, IL6
23night blindness10.4CD40LG, IL17A
24african histoplasmosis10.4CD40LG, MT-CO1
25predominantly cortical thymoma10.4IL10, IL6
26hepatitis10.4
27vestibule of mouth cancer10.4CD40LG, IL17A
28malignant eyelid melanoma10.4CD40LG, IL17A
29benign adult familial myoclonic epilepsy10.4IL10, IL6
30spastic monoplegia10.4CD40LG, IL10
31infancy electroclinical syndrome10.4IL10, IL6
32ethmoid sinus adenoid cystic carcinoma10.4IL10, IL6
33tricho odonto onycho dermal syndrome10.3IL17A, IL6
34pneumonic tularemia10.3CD40LG, IL10
35fibrous histiocytoma10.3CD40LG, HLA-DRB1
36polyhydramnios10.3IL10, IL6
37herpangina10.3IL10, IL6
38malignant gastric granular cell tumor10.3IL17A, IL6
39marchiafava bignami disease10.3IL10, IL6
40monoclonal paraproteinemia10.3CD40LG, IL6
41idiopathic neutropenia10.3IL10, IL6
42orbital lymphangioma10.3IL10, IL6
43disease_ontology10.3CD40LG, IL6
44central gyrate choroidal dystrophy10.3HLA-DRB1, IL6
45potato nose10.3HLA-DRB1, TLR2
46cauda equina syndrome10.3IL10, IL6
47complex regional pain syndrome10.3IL17A, IL6
48cyclothymic disorder10.3CD40LG, IL6
49scn8a encephalopathy10.3IL10, IL6
50non-secretory myeloma10.3CD40LG, IL6

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

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Human phenotypes related to Cystic Echinococcosis:

 64 (show all 37)
id Description HPO Frequency HPO Source Accession
1 pruritus64 hallmark (90%) HP:0000989
2 nausea and vomiting64 hallmark (90%) HP:0002017
3 abdominal pain64 hallmark (90%) HP:0002027
4 cystic liver disease64 hallmark (90%) HP:0006706
5 urticaria64 typical (50%) HP:0001025
6 hepatomegaly64 typical (50%) HP:0002240
7 abnormality of temperature regulation64 typical (50%) HP:0004370
8 impaired temperature sensation64 typical (50%) HP:0010829
9 biliary tract neoplasm64 typical (50%) HP:0100574
10 hydrocephalus64 occasional (7.5%) HP:0000238
11 visual impairment64 occasional (7.5%) HP:0000505
12 proptosis64 occasional (7.5%) HP:0000520
13 seizures64 occasional (7.5%) HP:0001250
14 cirrhosis64 occasional (7.5%) HP:0001394
15 portal hypertension64 occasional (7.5%) HP:0001409
16 ascites64 occasional (7.5%) HP:0001541
17 splenomegaly64 occasional (7.5%) HP:0001744
18 abnormality of eosinophils64 occasional (7.5%) HP:0001879
19 esophageal varix64 occasional (7.5%) HP:0002040
20 migraine64 occasional (7.5%) HP:0002076
21 respiratory insufficiency64 occasional (7.5%) HP:0002093
22 abnormality of the pleura64 occasional (7.5%) HP:0002103
23 hemoptysis64 occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage64 occasional (7.5%) HP:0002239
25 vertigo64 occasional (7.5%) HP:0002321
26 increased intracranial pressure64 occasional (7.5%) HP:0002516
27 hypotension64 occasional (7.5%) HP:0002615
28 osteolysis64 occasional (7.5%) HP:0002797
29 abnormality of the musculature64 occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis64 occasional (7.5%) HP:0004374
31 acute hepatic failure64 occasional (7.5%) HP:0006554
32 cranial nerve paralysis64 occasional (7.5%) HP:0006824
33 bone cyst64 occasional (7.5%) HP:0012062
34 immunologic hypersensitivity64 occasional (7.5%) HP:0100326
35 liver abscess64 occasional (7.5%) HP:0100523
36 chronic hepatic failure64 occasional (7.5%) HP:0100626
37 sepsis64 occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

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Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts3868

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

36
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes

Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 486)
idTitleAuthorsYear
1
In vivo evaluation of the efficacy of combined albedazole-IFN-I+ treatment for cystic echinococcosis in mice. (27928681)
2017
2
Expert Reliability for the World Health Organization Standardized Ultrasound Classification of Cystic Echinococcosis. (28070008)
2017
3
Proteomic investigation of human cystic echinococcosis in the liver. (27986452)
2017
4
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. (27273641)
2016
5
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. (27091868)
2016
6
Cystic echinococcosis in Southern Israel. (26751890)
2016
7
Diagnostic value of semi-purified antigens of hydatid cyst fluid in human cystic echinococcosis. (26751885)
2016
8
Sero-epidemiological value of some hydatid cyst antigen in diagnosis of human cystic echinococcosis. (27065597)
2016
9
The intermediate host immune response in cystic echinococcosis. (26683283)
2016
10
Cystic Echinococcosis Epidemiology in Spain Based on Hospitalization Records, 1997-2012. (27547975)
2016
11
The first meeting of the European Register of Cystic Echinococcosis (ERCE). (27126135)
2016
12
Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis. (27023205)
2016
13
The Economic Impact of Cystic Echinococcosis in Rio Negro Province, Argentina. (26787144)
2016
14
Treatment of Hepatic Cystic Echinococcosis in Patients from the Southeastern Rhodope Region of Bulgaria in 2004-2013: Comparison of Current Practices with Expert Recommendations. (26834196)
2016
15
First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". (27624561)
2016
16
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. (27085708)
2016
17
Control programme for cystic echinococcosis in Uruguay. (27223652)
2016
18
Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice. (27605805)
2016
19
Role of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients with cystic echinococcosis. (26889250)
2016
20
ZOONOTIC ENCOUNTERS AT THE SLAUGHTERHOUSE: PATHWAYS AND POSSIBILITIES FOR THE CONTROL OF CYSTIC ECHINOCOCCOSIS IN NORTHERN MOROCCO. (27428068)
2016
21
Gene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis. (27467147)
2016
22
Cystic echinococcosis is an occupational disease? (27605752)
2016
23
Retrospective study of human cystic echinococcosis over the past decade in France, using a nationwide hospital medical information database. (27473835)
2016
24
Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans. (26871432)
2016
25
Bayesian spatial analysis of the surgical incidence rate of human cystic echinococcosis in north-eastern Iran. (27496620)
2016
26
Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial. (26825878)
2016
27
Investigation of the use of serology and ultrasonography to detect hepatic cystic echinococcosis in Heilongjiang, China, using a Bayesian framework. (27412377)
2016
28
Cutaneous Disease as the First Manifestation of Cystic Echinococcosis. (27489329)
2016
29
Watch and Wait Management of Inactive Cystic Echinococcosis - Does the Path to Inactivity Matter - Analysis of a Prospective Patient Cohort. (27992434)
2016
30
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression. (27177776)
2016
31
Antibody profiling in ultrasound normal individuals with positive serology for cystic echinococcosis. (26729409)
2016
32
Abdominal Cystic Echinococcosis Treated with Albendazole. A Pediatric Cohort Study. (27589236)
2016
33
Cystic echinococcosis: Future perspectives of molecular epidemiology. (27237060)
2016
34
The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study. (27830083)
2016
35
Natural and induced antibodies contribute to differential susceptibility to secondary cystic echinococcosis of Balb/c and C57Bl/6 mice. (26238549)
2016
36
A study of morphological aspects of cystic echinococcosis in sheep in Sardinia. (27060775)
2016
37
Diagnosis of cystic echinococcosis in buffaloes by native 8A kDa antigen using latex agglutination test (LAT). (27876957)
2016
38
Percutaneous Treatment of Splenic Cystic Echinococcosis: Results of 12 Cases. (26676108)
2016
39
Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune-evasion strategy? (27120498)
2016
40
Development and evaluation of real-time loop-mediated isothermal amplification assay for rapid detection of cystic echinococcosis. (27619674)
2016
41
Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis. (27820824)
2016
42
Cystic Echinococcosis. (26677245)
2016
43
Cystic Echinococcosis: One Entity, Two Unusual Locations. (27222337)
2016
44
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
45
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis. (25566682)
2015
46
Open Conservative Surgical Management of Cystic Echinococcosis in a Tertiary Care Hospital, Nepal. (26393161)
2015
47
Cystic Echinococcosis Seropositivity in the Blood Samples Sent to Parasitology Laboratory of YA1zA1ncA1 YA+l University Medical Faculty between 2005 and 2013: Retrospective Assessment. (26470927)
2015
48
Human cystic echinococcosis in Heilongjiang Province, China: a retrospective study. (25887470)
2015
49
Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future? (26504805)
2015
50
A membranous material in the urine: A diagnosis of cystic echinococcosis at first glance. (26447921)
2015

Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL10, IL6
29.6IL10, IL6
3
Show member pathways
9.2IL10, IL17A, IL6
49.2HLA-DRB1, IL10, IL6
59.0IL10, IL6, TLR2
6
Show member pathways
9.0IL17A, IL6, TLR2
7
Show member pathways
9.0IL17A, IL6, TLR2
8
Show member pathways
8.8CD40LG, IL10, IL17A, IL6
98.8CD40LG, IL10, IL17A, IL6
10
Show member pathways
8.6CD40LG, HLA-DRB1, IL10, TLR2
11
Show member pathways
8.6IL10, IL17A, IL6, TLR2
128.6HLA-DRB1, IL10, IL6, TLR2
138.5HLA-DRB1, IL17A, IL6, TLR2
148.5CD40LG, IL10, IL6, TLR2
158.5CD40LG, IL10, IL6, TLR2
16
Show member pathways
7.7CD40LG, HLA-DRB1, IL10, IL17A, IL6, TLR2

GO Terms for genes affiliated with Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD40LG, IL17A, IL6

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:004210010.4CD40LG, IL10
2cellular response to estradiol stimulusGO:007139210.3IL10, IL6
3cellular response to hepatocyte growth factor stimulusGO:003572910.3IL10, IL6
4defense response to protozoanGO:004283210.3IL10, IL6
5response to electrical stimulusGO:005160210.3IL6, MT-CO1
6positive regulation of JAK-STAT cascadeGO:004642710.3IL10, IL6
7positive regulation of interleukin-10 productionGO:003273310.0CD40LG, TLR2
8positive regulation of interleukin-12 productionGO:003273510.0CD40LG, TLR2
9positive regulation of chemokine productionGO:003272210.0IL6, TLR2
10agingGO:00075689.7IL10, IL6, MT-ATP6, MT-CO1
11response to insulinGO:00328689.6IL10, IL6, TLR2
12positive regulation of NF-kappaB transcription factor activityGO:00510929.5CD40LG, IL6, TLR2
13response to lipopolysaccharideGO:00324969.0IL10, IL6, TLR2
14inflammatory responseGO:00069548.8CD40LG, IL10, IL17A, IL6, TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.8CD40LG, IL10, IL17A, IL6

Sources for Cystic Echinococcosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet