MCID: CYS008
MIFTS: 46

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

About this section
Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 40MESH via Orphanet, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 11 54 13
Echinococcus Granulosus Infection 11 68
Echinococcus Granulosus Infectious Disease of Thyroid 11
Echinococcus Granulosus Infectious Disease of Liver 11
Echinococcus Granulosus Infection, Unspecified 11
Echinococcus Granulosus Infection of Thyroid 11
Echinococcus Granulosus Infectious Disease 11
Echinococcus Granulosus Infection of Lung 11
Unspecified Echinococcus Granulosus 11
 
Thyroid Echinococcus Granulosus 11
Liver Echinococcus Granulosus 11
Lung Echinococcus Granulosus 11
Unilocular Hydatid Disease 11
Unilocular Echinococcosis 11
Hydatid Disease 54
Echinococcosis 68
Hydatidosis 54

Characteristics:

Orphanet epidemiological data:

54
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:1495
ICD9CM32 122.4
Orphanet54 ORPHA400
SNOMED-CT62 187138004, 75006000
MESH via Orphanet40 D004443
UMLS via Orphanet69 C0013502
ICD10 via Orphanet31 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more

Summaries for Cystic Echinococcosis

About this section
Disease Ontology:11 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to hepatitis and echinococcosis. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are IL-10 Pathway and African trypanosomiasis. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and lung, and related mouse phenotype endocrine/exocrine gland.

Related Diseases for Cystic Echinococcosis

About this section

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6HLA-DRB1, IL10, IL6
2echinococcosis11.7
3tungiasis10.2IL10, MT-ATP6
4cervical adenoid basal carcinoma10.2HLA-DRB1, IL10
5maturity-onset diabetes of the young10.2CD40LG, IL10
6oculoauricular syndrome10.2CD40LG, MT-CO1
7neonatal antiphospholipid syndrome10.2HLA-DRB1, IL17A
8diabetic angiopathy10.2CD40LG, IL10
9intracranial abscess10.2CES1, MT-CO1
10facial paralysis10.2CD40LG, IL10
11dermatitis herpetiformis10.2CD40LG, IL17A
12myofibroma10.2HLA-DRB1, IL10
13odontogenic myxoma10.2CD40LG, IL17A
14swine influenza10.2HLA-DRB1, IL6
15thrombophlebitis migrans10.2CD40LG, MT-CO1
16centronuclear myopathy 510.2CD40LG, IL10
17parkinson disease 1110.1IL10, IL17A
18angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.1HLA-DRB1, IL6
19ureter inverted papilloma10.1IL10, IL6
20neonatal hypoxic and ischemic brain injury10.1IL10, IL6
21spotted fever10.1CD40LG, TLR2
22childhood electroclinical syndrome10.1IL10, IL6
23transient tic disorder10.1IL10, IL6
24aseptic meningitis10.1HLA-DRB1, MT-CO1, TLR2
25hypertensive heart disease10.1CD40LG, TLR2
26heart conduction disease10.1CD40LG, HLA-DRB1, IL10
27dysplastic nevus syndrome10.1CD40LG, IL17A
28nystagmus, congenital motor, autosomal recessive10.1HLA-DRB1, TLR2
29clostridium difficile colitis10.1HLA-DRB1, IL6
30respiratory system disease10.1CD40LG, HLA-DRB1, IL10
31generalized atherosclerosis10.1CD40LG, IL6
32inner ear disease10.1CD40LG, IL6
33peripheral artery disease10.1HLA-DRB1, IL10, TLR2
34gastric lymphoma10.1IL17A, IL6
35angiostrongyliasis10.1MT-CO1, MT-ND1
36periarthritis10.1HLA-DRB1, IL10, TLR2
37erythematosquamous dermatosis10.1HLA-DRB1, IL10, TLR2
38motor peripheral neuropathy10.1CD40LG, IL10, IL17A
39xanthogranulomatous cholecystitis10.1CD40LG, IL10, IL17A
40endogenous depression10.1CD40LG, HLA-DRB1, TLR2
41chorioretinitis10.1CD40LG, HLA-DRB1, IL10
42nguyen syndrome10.1IL10, IL17A, TLR2
43familial acute necrotizing encephalopathy10.1HLA-DRB1, IL10
44complex regional pain syndrome10.1CD40LG, IL10, IL17A
45central sleep apnea10.0CD40LG, IL17A
46aortic coarctation10.0IL6, TLR2
47niemann-pick disease10.0HLA-DRB1, IL17A, IL6
48congenital hypothyroidism10.0CD40LG, IL10, TLR2
49rickettsialpox10.0CD40LG, IL10, TLR2
50lepromatous leprosy10.0IL10, IL6

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

About this section

MGI Mouse Phenotypes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.6CD40LG, CES1, IL10, IL17A, IL6, TLR2

Drugs & Therapeutics for Cystic Echinococcosis

About this section

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts4067

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS68/NDF-RT46:

Genetic Tests for Cystic Echinococcosis

About this section

Anatomical Context for Cystic Echinococcosis

About this section

MalaCards organs/tissues related to Cystic Echinococcosis:

36
Thyroid, Liver, Lung, Heart, Bone, Brain, Testes

Publications for Cystic Echinococcosis

About this section

Articles related to Cystic Echinococcosis:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
In vivo evaluation of the efficacy of combined albedazole-IFN-I+ treatment for cystic echinococcosis in mice. (27928681)
2017
2
Expert Reliability for the World Health Organization Standardized Ultrasound Classification of Cystic Echinococcosis. (28070008)
2017
3
Proteomic investigation of human cystic echinococcosis in the liver. (27986452)
2017
4
Cystic Echinococcosis: One Entity, Two Unusual Locations. (27222337)
2016
5
Cystic echinococcosis in Southern Israel. (26751890)
2016
6
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. (27085708)
2016
7
ZOONOTIC ENCOUNTERS AT THE SLAUGHTERHOUSE: PATHWAYS AND POSSIBILITIES FOR THE CONTROL OF CYSTIC ECHINOCOCCOSIS IN NORTHERN MOROCCO. (27428068)
2016
8
Diagnosis of cystic echinococcosis in buffaloes by native 8A kDa antigen using latex agglutination test (LAT). (27876957)
2016
9
Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis. (27023205)
2016
10
A study of morphological aspects of cystic echinococcosis in sheep in Sardinia. (27060775)
2016
11
Gene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis. (27467147)
2016
12
Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice. (27605805)
2016
13
Percutaneous Treatment of Splenic Cystic Echinococcosis: Results of 12 Cases. (26676108)
2016
14
Natural and induced antibodies contribute to differential susceptibility to secondary cystic echinococcosis of Balb/c and C57Bl/6 mice. (26238549)
2016
15
Retrospective study of human cystic echinococcosis over the past decade in France, using a nationwide hospital medical information database. (27473835)
2016
16
Cystic echinococcosis: Future perspectives of molecular epidemiology. (27237060)
2016
17
Erratum to: First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". (27846866)
2016
18
Control programme for cystic echinococcosis in Uruguay. (27223652)
2016
19
Sero-epidemiological value of some hydatid cyst antigen in diagnosis of human cystic echinococcosis. (27065597)
2016
20
Cutaneous Disease as the First Manifestation of Cystic Echinococcosis. (27489329)
2016
21
The Economic Impact of Cystic Echinococcosis in Rio Negro Province, Argentina. (26787144)
2016
22
Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial. (26825878)
2016
23
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. (27273641)
2016
24
Development and evaluation of real-time loop-mediated isothermal amplification assay for rapid detection of cystic echinococcosis. (27619674)
2016
25
Watch and Wait Management of Inactive Cystic Echinococcosis - Does the Path to Inactivity Matter - Analysis of a Prospective Patient Cohort. (27992434)
2016
26
Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis. (27820824)
2016
27
Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune-evasion strategy? (27120498)
2016
28
Antibody profiling in ultrasound normal individuals with positive serology for cystic echinococcosis. (26729409)
2016
29
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression. (27177776)
2016
30
Investigation of the use of serology and ultrasonography to detect hepatic cystic echinococcosis in Heilongjiang, China, using a Bayesian framework. (27412377)
2016
31
The first meeting of the European Register of Cystic Echinococcosis (ERCE). (27126135)
2016
32
Cystic echinococcosis is an occupational disease? (27605752)
2016
33
Bayesian spatial analysis of the surgical incidence rate of human cystic echinococcosis in north-eastern Iran. (27496620)
2016
34
The intermediate host immune response in cystic echinococcosis. (26683283)
2016
35
Diagnostic value of semi-purified antigens of hydatid cyst fluid in human cystic echinococcosis. (26751885)
2016
36
Cystic Echinococcosis. (26677245)
2016
37
Cystic Echinococcosis Epidemiology in Spain Based on Hospitalization Records, 1997-2012. (27547975)
2016
38
Abdominal Cystic Echinococcosis Treated with Albendazole. A Pediatric Cohort Study. (27589236)
2016
39
The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study. (27830083)
2016
40
Role of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients with cystic echinococcosis. (26889250)
2016
41
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. (27091868)
2016
42
Treatment of Hepatic Cystic Echinococcosis in Patients from the Southeastern Rhodope Region of Bulgaria in 2004-2013: Comparison of Current Practices with Expert Recommendations. (26834196)
2016
43
First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". (27624561)
2016
44
Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans. (26871432)
2016
45
Slaughterhouse survey of cystic echinococcosis in cattle and sheep from the Republic of Moldova. (25727141)
2015
46
eComment. Evidence-based diagnosis and treatment of intraaortic cystic echinococcosis. (26392585)
2015
47
Knowledge, attitude, and practices (KAP) and risk factors analysis related to cystic echinococcosis among residents in Tibetan communities, Xiahe County, Gansu Province, China. (25757370)
2015
48
A rare presentation of cystic echinococcosis: aortic involvement. (26180090)
2015
49
Evaluation of a New Immunochromatographic Test Using Recombinant Antigen B8/1 for Diagnosis of Cystic Echinococcosis. (26447116)
2015
50
Alveolar and cystic echinococcosis in Europe: Old burdens and new challenges. (26299934)
2015

Variations for Cystic Echinococcosis

About this section

Expression for genes affiliated with Cystic Echinococcosis

About this section
Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

About this section

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.5IL10, IL6
29.5IL10, IL6
39.5IL17A, IL6
49.1IL10, IL17A, IL6
5
Show member pathways
9.1IL10, IL17A, IL6
69.1HLA-DRB1, IL10, IL6
79.0IL10, IL6, TLR2
8
Show member pathways
9.0IL17A, IL6, TLR2
9
Show member pathways
9.0IL17A, IL6, TLR2
108.8CD40LG, IL10, IL17A, TLR2
11
Show member pathways
8.7CD40LG, HLA-DRB1, IL10, TLR2
12
Show member pathways
8.7CD40LG, IL10, IL17A, IL6
138.7CD40LG, IL10, IL17A, IL6
14
Show member pathways
8.6IL10, IL17A, IL6, TLR2
158.6HLA-DRB1, IL10, IL6, TLR2
168.5HLA-DRB1, IL17A, IL6, TLR2
178.5CD40LG, IL10, IL6, TLR2
188.5CD40LG, IL10, IL6, TLR2
19
Show member pathways
8.3CD40LG, HLA-DRB1, IL10, IL17A, IL6
20
Show member pathways
8.3CD40LG, HLA-DRB1, IL10, IL17A, IL6
21
Show member pathways
8.2HLA-DRB1, IL10, IL17A, IL6, TLR2

GO Terms for genes affiliated with Cystic Echinococcosis

About this section

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.6CD40LG, HLA-DRB1, IL17A, IL6

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:004210010.4CD40LG, IL10
2negative regulation of interferon-gamma productionGO:003268910.4HLA-DRB1, IL10
3negative regulation of T cell proliferationGO:004213010.4HLA-DRB1, IL10
4cellular response to estradiol stimulusGO:007139210.2IL10, IL6
5cellular response to hepatocyte growth factor stimulusGO:003572910.2IL10, IL6
6defense response to protozoanGO:004283210.2IL10, IL6
7response to electrical stimulusGO:005160210.2IL6, MT-CO1
8positive regulation of interleukin-10 productionGO:003273310.1CD40LG, TLR2
9positive regulation of interleukin-12 productionGO:003273510.1CD40LG, TLR2
10positive regulation of chemokine productionGO:003272210.0IL6, TLR2
11agingGO:00075689.6IL10, IL6, MT-ATP6, MT-CO1
12response to molecule of bacterial originGO:00022379.6IL10, TLR2
13response to insulinGO:00328689.6IL10, IL6, TLR2
14positive regulation of NF-kappaB transcription factor activityGO:00510929.5CD40LG, IL6, TLR2
15response to lipopolysaccharideGO:00324969.3IL10, IL6, TLR2
16inflammatory responseGO:00069548.8CD40LG, IL10, IL17A, IL6, TLR2
17immune responseGO:00069558.4CD40LG, HLA-DRB1, IL10, IL17A, IL6, TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7CD40LG, IL10, IL17A, IL6

Sources for Cystic Echinococcosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet