MCID: CYS008
MIFTS: 64

Cystic Echinococcosis malady

Infectious diseases, Rare diseases, Respiratory diseases, Liver diseases categories

Aliases & Classifications for Cystic Echinococcosis

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Sources:
8Disease Ontology, 48Orphanet, 61UMLS, 27ICD9CM, 56SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 8 48
Echinococcus Granulosus Infection of Thyroid 8 61
Echinococcus Granulosus Infection of Lung 8 61
Echinococcus Granulosus Infection 8 61
Echinococcus Granulosus Infectious Disease of Thyroid 8
Echinococcus Granulosus Infectious Disease of Liver 8
Echinococcus Granulosus Infection, Unspecified 8
Echinococcus Granulosus Infectious Disease 8
Unspecified Echinococcus Granulosus 8
 
Thyroid Echinococcus Granulosus 8
Liver Echinococcus Granulosus 8
Lung Echinococcus Granulosus 8
Unilocular Hydatid Disease 8
Unilocular Echinococcosis 8
Hydatid Disease 48
Echinococcosis 61
Hydatidosis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology8 DOID:1495
ICD9CM27 122.4
Orphanet48 400
MESH via Orphanet34 D004443
SNOMED-CT56 187138004, 75006000
ICD10 via Orphanet26 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
UMLS via Orphanet62 C0013502

Summaries for Cystic Echinococcosis

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Disease Ontology:8 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection of thyroid, is related to echinococcosis and paragonimiasis, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-ATP6 (mitochondrially encoded ATP synthase 6), and among its related pathways are TRAF Pathway and Immune response IL 12 signaling pathway. The drug albendazole and the compounds solium and glucuronoxylomannan have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related mouse phenotypes are tumorigenesis and skeleton.

Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis33.1MT-CO1
2paragonimiasis30.5IGHE
3aspergillosis30.5TLR4, TLR2
4invasive aspergillosis30.4TLR4, TLR2
5toxocariasis30.4RNASE3, IGHE
6eosinophilia29.6IGHE, IL2RA, IL10, RNASE3
7hepatitis10.7
8spondyloarthropathy 110.6HLA-B
9celiac disease10.5HLA-DQB1
10farmer's lung10.5IL2RA
11mitochondrial disorders10.4MT-ATP6, MT-CO1
12leber hereditary optic neuropathy10.4MT-ATP6
13atopic dermatitis10.4RNASE3, TLR2
14cysticercosis10.4
15colorectal cancer10.4TAP1, TAP2
16reactive arthritis10.3TAP2, HLA-B
17leprosy10.3HLA-DRB1, TLR2
18pouchitis10.3TLR4, TLR2
19melioidosis10.3TLR4, TLR2
20multiple sclerosis, disease progression, modifier of10.3HLA-DQB1, HLA-DRB1
21anisakiasis10.3IGHE, RNASE3
22neisseria meningitidis infection10.3TLR2, TLR4
23trichinosis10.3
24hashimoto thyroiditis10.3IL2RA, IL12B, HLA-B
25parasitic helminthiasis infectious disease10.3RNASE3, IGHE
26intrinsic asthma10.3RNASE3, IGHE
27allergic conjunctivitis10.3IGHE, RNASE3
28kimura disease10.2IGHE, RNASE3
29eosinophilic pneumonia10.2RNASE3, IGHE
30asthma10.2IGHE, RNASE3
31vogt-koyanagi-harada disease10.2HLA-DRB1, IL2RA
32pulmonary eosinophilia10.2RNASE3, IGHE
33conjunctivitis10.2RNASE3, IGHE
34sjogren's syndrome10.2TAP2, TAP1, IL2RA
35allergic rhinitis10.2RNASE3, IGHE
36herpes simplex10.2TLR2, HLA-B, EEF1D, IL12B
37food allergy10.2RNASE3, IGHE
38meningitis10.2HLA-B, TLR2, IL6
39dermatitis10.2RNASE3, IGHE
40immunoglobulin alpha deficiency10.2HLA-DQB1, IGHE
41vernal keratoconjunctivitis10.2RNASE3, IGHE
42keratitis10.2IL17A, TLR2, TLR4
43arthritis10.2IL17A, IL6
44mastitis10.2TLR2, TLR4
45encephalitis10.2IL17A, IL12B, TLR2, HLA-B
46gastritis10.2TLR4, TLR2, IL17A
47cervical cancer, somatic10.1TAP1, TAP2, IL17A
48cerebritis10.1
49alveolar echinococcosis10.1
50peritonitis10.1

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

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Symptoms:

 48 (show all 44)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • urticaria
  • hepatomegaly/liver enlargement (excluding storage disease)
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • hot flushes/sensation of cold
  • proptosis/exophthalmos
  • visual loss/blindness/amblyopia
  • dizziness
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • acute hepatic failure
  • chronic hepatic failure
  • liver/hepatic abscess
  • portal hypertension
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • hypotension
  • hydrocephaly
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • cranial hypertension
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • eosinophils anomalies/hypereosinophilia
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Cystic Echinococcosis:

(show all 37)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 urticaria typical (50%) HP:0001025
6 hepatomegaly typical (50%) HP:0002240
7 abnormality of temperature regulation typical (50%) HP:0004370
8 impaired temperature sensation typical (50%) HP:0010829
9 biliary tract neoplasm typical (50%) HP:0100574
10 hydrocephalus occasional (7.5%) HP:0000238
11 visual impairment occasional (7.5%) HP:0000505
12 proptosis occasional (7.5%) HP:0000520
13 seizures occasional (7.5%) HP:0001250
14 cirrhosis occasional (7.5%) HP:0001394
15 portal hypertension occasional (7.5%) HP:0001409
16 ascites occasional (7.5%) HP:0001541
17 splenomegaly occasional (7.5%) HP:0001744
18 abnormality of eosinophils occasional (7.5%) HP:0001879
19 esophageal varix occasional (7.5%) HP:0002040
20 migraine occasional (7.5%) HP:0002076
21 respiratory insufficiency occasional (7.5%) HP:0002093
22 abnormality of the pleura occasional (7.5%) HP:0002103
23 hemoptysis occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
25 vertigo occasional (7.5%) HP:0002321
26 increased intracranial pressure occasional (7.5%) HP:0002516
27 hypotension occasional (7.5%) HP:0002615
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
31 acute hepatic failure occasional (7.5%) HP:0006554
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 liver abscess occasional (7.5%) HP:0100523
36 chronic hepatic failure occasional (7.5%) HP:0100626
37 sepsis occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

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Drug clinical trials:

Search ClinicalTrials for Cystic Echinococcosis

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

31
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes, Skin, Spleen, T cells, Tongue

Animal Models for Cystic Echinococcosis or affiliated genes

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MGI Mouse Phenotypes related to Cystic Echinococcosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1TLR2, IL6, IL12B, TAP1, IL10, TLR4
2MP:00053908.1IL12B, IL10, TLR4, TLR2, IL6, IL17A
3MP:00053887.8TLR2, TLR4, IL10, IL12B, IL6, IL17A
4MP:00053697.7TLR4, HLA-DQB1, IL6, IL10, TLR2, MT-CO1
5MP:00053817.5IL10, IL17A, IL2RA, TLR4, TLR2, HLA-DQB1
6MP:00053766.9IGHE, HLA-DQB1, IL10, IL6, TLR4, MT-CO1
7MP:00107686.8IL12B, TLR4, TLR2, HLA-DQB1, HLA-B, IL6
8MP:00053976.2IGHE, TAP2, HLA-B, HLA-DQB1, TLR4, IL2RA
9MP:00053876.0TLR4, IGHE, HLA-DQB1, TLR2, MT-CO1, IL2RA

Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 416)
idTitleAuthorsYear
1
Knowledge, attitude, and practices (KAP) and risk factors analysis related to cystic echinococcosis among residents in Tibetan communities, Xiahe County, Gansu Province, China. (25757370)
2015
2
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis. (25566682)
2015
3
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
4
Laparoscopic approach for total cystectomy in treating hepatic cystic echinococcosis. (25489977)
2014
5
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
6
The Production and Comparative Evaluation of Native and Recombinant Antigens for the Fast Serodiagnosis of Cystic Echinococcosis with Dot Immunogold Filtration Assay. (25313824)
2014
7
Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum. (25706429)
2014
8
Evaluation of purified antigen fraction in the immunodiagnosis of cystic echinococcosis. (24828349)
2014
9
Detection of hydatid-specific antibodies in the serum and urine for the diagnosis of cystic echinococcosis in patients from the Kashmir Valley, India. (24429044)
2014
10
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis. (24372157)
2013
11
A review of the global prevalence, molecular epidemiology and economics of cystic echinococcosis in production animals. (23084536)
2013
12
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
13
High resolution melting technique for molecular epidemiological studies of cystic echinococcosis: differentiating G1, G3, and G6 genotypes of Echinococcus granulosus sensu lato. (23832641)
2013
14
Molecular diagnosis of cystic echinococcosis in humans from central Poland. (23535071)
2013
15
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
16
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
17
Development and evaluation of flow through technique for diagnosis of cystic echinococcosis in sheep. (21507576)
2011
18
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
19
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
20
A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom. (21896804)
2011
21
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
22
Isolated type I pelvic cystic echinococcosis mimicking ovarian tumor. (22540100)
2011
23
Cystic echinococcosis of the pelvic bone with recurrences: a case report. (22072828)
2011
24
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
25
TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis. (20193774)
2010
26
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
27
Estimating the production losses due to cystic echinococcosis in ruminants in Turkey. (19482428)
2009
28
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
29
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
30
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
31
Cardiac manifestation of cystic echinococcosis: comparison of dual-source cardio-computed tomography and cardiac magnetic resonance imaging and their impact on disease management. (17984345)
2007
32
Comparative evaluation of western blotting in hepatic and pulmonary cystic echinococcosis. (17285854)
2006
33
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
34
Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis. (16218215)
2005
35
Epidemiological evaluations of the efficacy of slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and animals. (16231860)
2005
36
Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico. (15533292)
2004
37
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
38
Human cystic echinococcosis in Sardinia during the 20th century. (16044696)
2004
39
Cystic echinococcosis in the Berber of the Mid Atlas mountains, Morocco: new insights into the natural history of the disease in humans. (15257798)
2004
40
Evaluation of use of recombinant Em18 and affinity-purified Em18 for serological differentiation of alveolar echinococcosis from cystic echinococcosis and other parasitic infections. (12843091)
2003
41
Rapid dot-ELISA for the detection of specific antigens in the cyst fluid from human cases of cystic echinococcosis. (12537630)
2002
42
Prevalence, intensity, and fertility of ovine cystic echinococcosis in the central Peruvian Andes. (11579878)
2001
43
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
44
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. (11116435)
2000
45
Editorial response: Treatment of cystic echinococcosis--improving but still limited. (10476733)
1999
46
Short report: An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus-specific DNA sequences. (9660465)
1998
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
Public health importance of cystic echinococcosis in Latin America. (9236943)
1997
49
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
50
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989

Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TLR2, IL12B
29.9IL2RA, IL12B
3
Show member pathways
9.7TAP2, TAP1, HLA-B
49.5IL12B, TLR4, TLR2
59.4HLA-B, HLA-DRB1, HLA-DQB1
6
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.4HLA-DRB1, IL12B, IL2RA
7
Show member pathways
9.4TLR4, TLR2, HLA-DQB1
8
Show member pathways
9.4TLR2, IL2RA, TLR4
9
Show member pathways
9.3HLA-DRB1, IL2RA, HLA-DQB1
10
Show member pathways
9.2IL6, IL17A, TLR2
119.2HLA-DRB1, HLA-DQB1, IL10
12
Show member pathways
Immune response T cell receptor signaling pathway59
Immune response CD28 signaling59
Immune response ICOS pathway in T helper cell59
9.2HLA-DRB1, IGHE, HLA-DQB1
13
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.1IL6, TLR4, TLR2
149.1TLR2, IL6, TLR4
159.1IL6, IL12B, IL10
169.1IL6, IL12B, IL10
17
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.1HLA-DQB1, HLA-DRB1, IL2RA, IL12B
189.0IL2RA, TAP2, TAP1, IL10
199.0IL2RA, IL6, HLA-DRB1
208.9TLR4, IL6, IL10
218.9HLA-DQB1, HLA-DRB1, HLA-B, IL10
22
Show member pathways
8.9IL17A, TLR4, IL6, IL12B
23
Show member pathways
8.9TAP1, TAP2, HLA-B, HLA-DRB1, HLA-DQB1
248.9TLR4, IL6, TLR2, IL12B
25
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.8IL12B, IL6, IL17A, IL10
268.7TLR4, IL6, IL2RA, TLR2
27
Show member pathways
Type III interferon signaling36
8.7IL6, IL12B, IL10, IL2RA
288.7TLR4, IL6, IL12B, IL10
298.6IL10, IL12B, IL6, HLA-DRB1
308.6TLR2, IL10, IL6, TLR4
31
Show member pathways
8.6IL6, TLR4, IL17A, TLR2, IL12B
32
Show member pathways
8.6IL2RA, TLR4, HLA-DRB1, HLA-DQB1, TLR2
338.4HLA-DQB1, HLA-DRB1, IL2RA, HLA-B, IL6
34
Show member pathways
8.4HLA-B, IL6, HLA-DRB1, IL2RA, HLA-DQB1
358.4TLR2, TLR4, IL12B, IL6, IL10
36
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.4TLR2, IL6, IL12B, IL10, TLR4
378.2TLR4, HLA-DQB1, TAP1, TLR2, HLA-B, TAP2
38
Show member pathways
IL27-mediated signaling events36
8.1IL17A, TLR4, TLR2, IL12B, IL6, IL10
398.0HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL17A, IL6
40
Show member pathways
8.0IL2RA, IL17A, IL10, IL12B, IL6, TLR4
41
Show member pathways
8.0TLR2, TLR4, IL2RA, IL6, IL10, IL12B
427.6IL12B, IL10, TLR2, HLA-DRB1, HLA-DQB1, TLR4
43
Show member pathways
7.3TLR2, HLA-DQB1, HLA-DRB1, TLR4, IL17A, IL10
44
Show member pathways
6.9TAP1, RNASE3, IL10, IL12B, IL6, TAP2
45
Show member pathways
6.1TAP2, HLA-B, HLA-DQB1, IL2RA, TAP1, TLR4

Compounds for genes affiliated with Cystic Echinococcosis

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Compounds related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1solium4410.2MT-ATP6, HLA-B, MT-CO1
2glucuronoxylomannan449.6TLR4, TLR2, IL10
3gliadin449.4HLA-DQB1, RNASE3, IGHE
45 aminosalicylic acid449.3IL2RA, IL12B, IL10
5praziquantel44 1110.3IL10, RNASE3, IGHE
6hbd2449.3IL6, TLR2, TLR4
7poly(i-c)449.2TLR4, TLR2, IL6, IL12B
8montelukast44 50 28 1112.2IGHE, RNASE3, IL10, IL2RA
9latex449.1TLR4, IGHE, TLR2, HLA-B, RNASE3
10pentoxifylline44 1110.0IL6, IL12B, IL10, IL2RA
11polymyxin b449.0TLR2, TLR4, IL6, IL10
12ccl344 289.9IL10, TLR4, IL6, TLR2
13il-12448.8IL10, IL12B, IL6
14imiquimod44 60 28 1111.8IL10, IL12B, TLR4, TLR2, IL6
15peptidoglycan44 289.8IL6, TLR2, TLR4, IL12B, IL10
16ivig448.7IL10, IGHE, IL2RA, IL6
172,5-oligoadenylate448.7IL10, IL2RA, TLR4, IL6, HLA-B
18tacrolimus44 50 1110.7TLR2, HLA-B, TLR4, IL2RA, IL17A, IL10
19allergens448.7TLR4, HLA-DRB1, IGHE, IL10, RNASE3
20polysaccharide448.7IL2RA, RNASE3, TLR4, TLR2, HLA-B, IGHE
21h2o2448.7TLR4, TLR2, PRDX4, IL2RA, HLA-B, RNASE3
22oligonucleotide448.7RNASE3, HLA-DQB1, TAP1, TAP2, HLA-DRB1, HLA-B
23lipoteichoic acid448.6TLR4, IL10, IL12B, IL6, HLA-B, TLR2
24polyinosinic-polycytidylic acid448.6TLR4, TLR2, IL10, HLA-B, IL6, IL12B
25fibrinogen448.5RNASE3, HLA-B, IL6, TLR2, TLR4
26prednisolone44 28 1110.5IL2RA, IGHE, IL10, IL6, RNASE3
27calcitriol44 60 24 1111.5TLR4, TLR2, IL2RA, IL10, IL6
28lactate448.5RNASE3, IGHE, HLA-B, TLR4, IL6, PRDX4
29il 10448.4IL6, TLR4, IL2RA, IL10, IL12B, TLR2
30sb 20358044 609.4TLR4, IL6, IL12B, IL10, IL17A, TLR2
31n acetylcysteine448.4IL2RA, TLR4, IGHE, IL6, RNASE3
32ifn-alpha448.4TLR4, TAP1, IL2RA, IL17A, IL10, IL6
33creatinine448.3RNASE3, IGHE, IL6, IL17A, HLA-B, IL2RA
34aspartate448.3HLA-DQB1, TLR4, HLA-B, IL2RA, IGHE, IL10
35infliximab44 50 1110.2IGHE, TLR4, IL2RA, IL10, IL6, IL17A
36atp44 289.0PRDX4, MT-CO1, MT-ATP6, TAP2, HLA-DRB1, HLA-B
37endotoxin448.0TLR4, TLR2, HLA-B, RNASE3, IL12B, IL6
38cycloheximide448.0TLR2, IL10, IL6, IL12B, IGHE, TLR4
39nitric oxide44 24 1110.0IL17A, IL10, IL6, RNASE3, TLR4, TLR2
40vitamin d447.9IL6, IL12B, IGHE, TLR2, IL10, TLR4
41histamine44 28 249.9IL2RA, RNASE3, TLR4, TLR2, IGHE, IL10
42alanine447.8HLA-DRB1, TLR2, TLR4, IL6, TAP1, TAP2
43methotrexate50 44 119.7IL17A, IGHE, HLA-DRB1, TLR4, IL6, IL10
44rantes447.7IL2RA, IL10, IL17A, IL6, RNASE3, TLR4
45pge2447.6RNASE3, TLR4, IL6, IL12B, IL10, IL17A
46vegf447.5IL6, TLR4, IGHE, TLR2, RNASE3, IL2RA
47lipid447.4PRDX4, RNASE3, TLR2, HLA-B, TLR4, EEF1D
48cyclosporin a44 28 609.4IGHE, HLA-B, TLR2, TLR4, IL6, IL10
49dexamethasone44 50 28 1110.3IL6, IL10, IGHE, HLA-B, TLR2, TLR4
50tyrosine446.7HLA-DRB1, HLA-DQB1, HLA-B, TLR2, EEF1D, IL2RA

GO Terms for genes affiliated with Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:00428259.9TAP2, TAP1
2MHC class II protein complexGO:00426139.6HLA-DQB1, HLA-DRB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-B, HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125079.5HLA-DRB1, HLA-DQB1, HLA-B
5extracellular spaceGO:00056158.6IL6, IL12B, IL10, IL17A, PRDX4
6external side of plasma membraneGO:00098978.1IL6, IL17A, IL2RA, TLR4, TLR2, HLA-DRB1
7plasma membraneGO:00058867.5HLA-B, HLA-DQB1, HLA-DRB1, TLR2, TLR4, IL2RA

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:004696710.3TAP2, TAP1
2oligopeptide transmembrane transportGO:003567210.3TAP1, TAP2
3intracellular transport of viral protein in host cellGO:001906010.3TAP1, TAP2
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:001988510.3TAP2, TAP1
5peptide transportGO:001583310.3TAP1, TAP2
6cellular response to lipoteichoic acidGO:007122310.1TLR2, TLR4
7positive regulation of macrophage cytokine productionGO:006090710.1TLR4, TLR2
8immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DQB1, HLA-DRB1
9positive regulation of tumor necrosis factor biosynthetic processGO:004253510.0TLR4, TLR2
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:000247910.0TAP1, HLA-B, TAP2
11antigen processing and presentation of exogenous peptide antigen via MHC class IGO:004259010.0HLA-B, TAP1, TAP2
12positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.0TLR4, TLR2
13positive regulation of osteoclast differentiationGO:004567210.0IL12B, IL17A
14detection of bacteriumGO:001604510.0HLA-B, HLA-DRB1
15humoral immune response mediated by circulating immunoglobulinGO:000245510.0HLA-DRB1, HLA-DQB1
16I-kappaB phosphorylationGO:000725210.0PRDX4, TLR2, TLR4
17antigen processing and presentation of peptide antigen via MHC class IGO:000247410.0HLA-B, TAP1, TAP2
18negative regulation of interleukin-17 productionGO:00327009.9TLR4, IL12B, TLR2
19positive regulation of interleukin-10 productionGO:00327339.9TLR4, IL12B, TLR2
20positive regulation of NF-kappaB import into nucleusGO:00423469.9IL12B, TLR4, TLR2
21positive regulation of interleukin-12 productionGO:00327359.9TLR2, TLR4, IL12B
22positive regulation of tumor necrosis factor productionGO:00327609.9IL12B, TLR2, TLR4
23positive regulation of inflammatory responseGO:00507299.9TLR2, TLR4, IL12B
24positive regulation of T cell mediated cytotoxicityGO:00019169.9HLA-B, IL12B, TAP1, TAP2
25positive regulation of MHC class II biosynthetic processGO:00453489.9TLR4, IL10
26negative regulation of interleukin-12 productionGO:00326959.9IL10, TLR2
27negative regulation of growth of symbiont in hostGO:00441309.8IL10, TLR2, IL12B
28inflammatory response to antigenic stimulusGO:00024379.8IL2RA, HLA-DRB1
29interferon-gamma-mediated signaling pathwayGO:00603339.8HLA-DRB1, HLA-DQB1, HLA-B
30T-helper 1 type immune responseGO:00420889.8HLA-DRB1, TLR4, IL12B
31positive regulation of activated T cell proliferationGO:00421049.8IL12B, IL2RA
32positive regulation of interleukin-8 productionGO:00327579.7TLR2, TLR4
33positive regulation of interferon-beta productionGO:00327289.7TLR2, TLR4
34defense response to protozoanGO:00428329.7IL12B, IL6
35cellular response to lipopolysaccharideGO:00712229.7IL10, TLR4, IL12B
36defense response to Gram-negative bacteriumGO:00508299.6IL12B, TLR4, IL6
37positive regulation of chemokine productionGO:00327229.6TLR2, TLR4, IL6
38positive regulation of nitric oxide biosynthetic processGO:00454299.5IL6, TLR4, TLR2
39negative regulation of T cell proliferationGO:00421309.5HLA-DRB1, IL10, IL2RA
40defense response to bacteriumGO:00427429.5IL10, TLR4, RNASE3
41positive regulation of interleukin-6 productionGO:00327559.5TLR2, TLR4, IL6
42negative regulation of interferon-gamma productionGO:00326899.5HLA-DRB1, TLR4, IL10
43response to insulinGO:00328689.4TLR2, IL6, IL10
44positive regulation of NF-kappaB transcription factor activityGO:00510929.3IL6, TLR4, TLR2
45negative regulation of interleukin-6 productionGO:00327159.2IL10, TLR4
46cytokine-mediated signaling pathwayGO:00192219.2HLA-DRB1, IL6, HLA-DQB1, HLA-B
47inflammatory responseGO:00069549.0IL6, IL17A, IL10, TLR2
48positive regulation of transcription from RNA polymerase II promoterGO:00459448.6TLR2, TLR4, IL10, IL6, IL17A
49immune responseGO:00069558.0HLA-DRB1, IL2RA, TLR4, TLR2, HLA-DQB1, HLA-B

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:001519710.1TAP2, TAP1
2MHC class Ib protein bindingGO:002302910.1TAP2, TAP1
3tapasin bindingGO:004698010.1TAP2, TAP1
4oligopeptide-transporting ATPase activityGO:001542110.1TAP1, TAP2
5TAP1 bindingGO:004697810.0TAP2, TAP1
6TAP2 bindingGO:00469799.9TAP2, TAP1
7lipopolysaccharide receptor activityGO:00018759.9TLR4, TLR2
8MHC class I protein bindingGO:00422889.6TAP2, TAP1
9MHC class II receptor activityGO:00323959.6HLA-DQB1, HLA-DRB1
10peptide antigen bindingGO:00426059.5TAP2, TAP1, HLA-DRB1, HLA-B
11growth factor activityGO:00080839.1IL6, IL12B, IL10
12cytokine activityGO:00051259.0IL17A, IL10, IL12B, IL6

Sources for Cystic Echinococcosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet