MCID: CYS008
MIFTS: 50

Cystic Echinococcosis malady

Infectious, Respiratory, Liver categories

Summaries for Cystic Echinococcosis

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to sepsis and alveolar echinococcosis. An important gene associated with Cystic Echinococcosis is MT-ATP6 (mitochondrially encoded ATP synthase 6), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds pentoxifylline and solium have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cystic Echinococcosis

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Respiratory, Liver


Aliases & Descriptions:

cystic echinococcosis 8
echinococcus granulosus infection 8 61
echinococcus granulosus infectious disease of thyroid 8
echinococcus granulosus infectious disease of liver 8
echinococcus granulosus infection, unspecified 8
echinococcus granulosus infection of thyroid 8
echinococcus granulosus infectious disease 8
echinococcus granulosus infection of lung 8
unspecified echinococcus granulosus 8
thyroid echinococcus granulosus 8
liver echinococcus granulosus 8
lung echinococcus granulosus 8
unilocular hydatid disease 8
unilocular echinococcosis 8


External Ids:

Disease Ontology8 DOID:1495
ICD9CM27 122.4
SNOMED-CT57 75006000, 187138004

Related Diseases for Cystic Echinococcosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Clinical Features for Cystic Echinococcosis

Drugs & Therapeutics for Cystic Echinococcosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cystic Echinococcosis

Drug clinical trials:

Search ClinicalTrials for Cystic Echinococcosis

Search NIH Clinical Center for Cystic Echinococcosis

Search CenterWatch for Cystic Echinococcosis

Genetic Tests for Cystic Echinococcosis

Anatomical Context for Cystic Echinococcosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cystic Echinococcosis:

33
Skin, Liver, Tongue, Brain, Lung, Spleen, Heart, Thyroid, T cells, B cells

Animal Models for Cystic Echinococcosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cystic Echinococcosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1TLR2, HLA-DQB1, HLA-B, MT-CO1, PRDX4, IL2RA
2MP:00053877.4TAP2, TLR4, TLR2, HLA-DQB1, HLA-B, MT-CO1
3MP:00053977.4HLA-B, HLA-DQB1, TLR2, TLR4, IGHE, IL2RA

Publications for Cystic Echinococcosis

Sources:
51PubMed
See all sources

Articles related to Cystic Echinococcosis:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Human cystic echinococcosis in west azerbaijan, northwest iran: a retrospective hospital based survey from 2000 to 2009. (23914247)
2013
2
Oxidant/antioxidant status in cattle with liver cystic echinococcosis. (23414616)
2013
3
Isolated ruptured inter-atrial septal cystic echinococcosis during pregnancy. (23710802)
2013
4
Spinal cystic echinococcosis--a systematic analysis and review of the literature: part 2. Treatment, follow-up and outcome. (24069501)
2013
5
Cystic echinococcosis in Romania: an epidemiological survey of livestock demonstrates the persistence of hyperendemicity. (23075460)
2012
6
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
7
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China. (22039558)
2011
8
Comparative performances of flubendazole and albendazole in cystic echinococcosis: ex vivo activity, plasma/cyst disposition, and efficacy in infected mice. (21930885)
2011
9
Cystic echinococcosis in Sudan and South Sudan: research history of a neglected zoonosis. (22191175)
2011
10
An abattoir-based study on the prevalence and economic losses due to cystic echinococcosis in slaughtered herbivores in Ahwaz, south-western Iran. (20398435)
2011
11
Demographic and clinical characteristics of patients with anaphylactic shock after surgery for cystic echinococcosis. (21896803)
2011
12
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china. (20042519)
2010
13
Cystic echinococcosis in Greece. Past and present. (21073143)
2010
14
Study of cystic echinococcosis in slaughtered animals in Al Baha region, Saudi Arabia: interaction between some biotic and abiotic factors. (19744464)
2010
15
Widespread co-endemicity of human cystic and alveolar echinococcosis on the eastern Tibetan Plateau, northwest Sichuan/southeast Qinghai, China. (19941830)
2010
16
Pathology quiz case 1. Sino-orbital cystic echinococcosis (CE). (19841351)
2009
17
Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice. (19628054)
2009
18
Evaluation of eosinophil cationic protein levels with clinical symptoms and laboratory findings of patients with cystic echinococcosis]. (19621614)
2009
19
Molecular update on cystic echinococcosis in cattle and water buffaloes of southern Italy. (18234031)
2008
20
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. (18692060)
2008
21
Assessment of Echinococcus granulosus somatic protoscolex antigens for serological follow-up of young patients surgically treated for cystic echinococcosis. (18367566)
2008
22
Dot-Elisa for evaluation of hydatid cyst wall, protoscoleces and hydatid cyst fluid antigens in the serodiagnosis of cystic echinococcosis. (18813764)
2008
23
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
24
Cardiac manifestation of cystic echinococcosis: comparison of dual-source cardio-computed tomography and cardiac magnetic resonance imaging and their impact on disease management. (17984345)
2007
25
Sonographic management of complicated cystic echinococcosis. (23396652)
2007
26
Identification of a diagnostic antibody-binding region on the immunogenic protein EpC1 from Echinococcus granulosus and its application in population screening for cystic echinococcosis. (17403055)
2007
27
Genotyping of human cystic echinococcosis in Xinjiang, PR China. (16836793)
2006
28
The value of ultrasonography alone in screening surveys of cystic echinococcosis in children in Turkey. (16928466)
2006
29
Serum malondialdehyde level in patients with cystic echinococcosis. (17106545)
2006
30
Cystic echinococcosis in the Americas. (16376604)
2006
31
Cystic echinococcosis in slaughtered sheep in Sardinia (Italy). (16226378)
2006
32
A discrepancy between cystic echinococcosis confirmed by ultrasound and seropositivity in Turkish children. (15652335)
2005
33
Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia). (15990129)
2005
34
The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis. (16212799)
2005
35
Short report: endemic focus of cystic echinococcosis in a coastal city of Peru. (15381815)
2004
36
The evaluation of HLA-DRB1 antigens as susceptibility markers for unilocular cystic echinococcosis in Egyptian patients. (14999467)
2004
37
Alkaline phosphatase from Echinococcus granulosus metacestodes for immunodiagnosis of human cystic echinococcosis. (15587313)
2004
38
Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis. (14984830)
2004
39
Echinococcosis on the Tibetan Plateau: prevalence and risk factors for cystic and alveolar echinococcosis in Tibetan populations in Qinghai Province, China. (15027608)
2003
40
Performance characteristics and quality control of community based ultrasound surveys for cystic and alveolar echinococcosis. (12606098)
2003
41
Cystic echinococcosis with perforation into the biliary tract in an eight-year-old girl. (12015661)
2002
42
Risk factors associated with human cystic echinococcosis in Jordan: results of a case-control study. (10723525)
2000
43
Serum cytokine detection in the clinical follow up of patients with cystic echinococcosis. (10193425)
1999
44
Immunological diagnosis of human cystic echinococcosis: utility of discriminant analysis applied to the enzyme-linked immunoelectrotransfer blot. (10391851)
1999
45
Association between asymptomatic cystic echinococcosis and some types of rural water supplies. (10348222)
1999
46
Effect of mebendazole on human cystic echinococcosis: the role of dosage and treatment duration. (10656037)
1999
47
Epidemiological studies on cystic echinococcosis in China--a review. (7546341)
1995
48
First record of cystic echinococcosis in free-ranging baboons, Papio hamadrysas, in Saudi Arabia. (7668924)
1995
49
A critical approach to the concepts of control and eradication of echinococcosis/hydatidosis and taeniasis/cysticercosis. (3294658)
1987
50
Taeniasis, cysticercosis and echinococcosis/hydatidosis in Nigeria: III--prevalence of bovine and porcine cysticercosis, and hydatid cyst infection based on joint examination of slaughtered food animals. (7194897)
1980

Genetic Variations for Cystic Echinococcosis

Expression for genes affiliated with Cystic Echinococcosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 52QIAGEN, 60Tocris Bioscience, 38NCBI BioSystems Database, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TLR2, TLR4
29.9TLR4, TLR2
3
Hide members
9.9HLA-B, TAP1, TAP2
49.9TAP2, TAP1, HLA-B
59.7TLR4, TLR2, IL12B
69.7IL12B, TLR2, TLR4
7
Hide members
9.7IL2RA, TLR2, TLR4
8
Hide members
9.7HLA-DRB1, IL2RA, IL12B
99.7TLR4, IL10, IL12B
109.6HLA-DRB1, IL10, IL12B
119.5HLA-DQB1, HLA-DRB1, IL10
129.5TAP2, TAP1, IL10, IL2RA
139.4IL2RA, HLA-DRB1, HLA-B, HLA-DQB1
14
Hide members
9.4HLA-DQB1, HLA-B, HLA-DRB1, IL2RA
15
Hide members
9.4TLR4, TLR2, IL10, IL12B
16
Hide members
9.4TLR4, TLR2, IL10, IL12B
179.4IL12B, IL10, TLR2, TLR4
189.4IL12B, IL2RA, HLA-DRB1, HLA-DQB1
199.3IL10, HLA-DRB1, HLA-B, HLA-DQB1
20
Hide members
9.1IL12B, IL10, IL2RA, TLR2, TLR4
21
Hide members
9.0IL2RA, HLA-DRB1, HLA-DQB1, TLR2, TLR4
22
Hide members
8.8HLA-DQB1, HLA-B, HLA-DRB1, IL2RA, IL10, IL12B
23
Hide members
8.8TLR4, TLR2, HLA-DQB1, HLA-DRB1, IL10, IL12B
248.8TLR4, TLR2, HLA-DQB1, HLA-DRB1, IL10, IL12B
258.7TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, TAP1
26
Hide members
7.9TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, IGHE
27
Hide members
7.8EEF1D, TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1

Compounds for genes affiliated with Cystic Echinococcosis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.5IL12B
2solium4510.4MT-CO1, MT-ATP6, HLA-B
3tacrolimus45 50 1112.3TLR2, IL2RA
4cycloheximide4510.3TLR2
5arabinogalactan4510.3TLR2, TLR4
6diaminopimelic acid4510.3TLR2, TLR4
7pam2csk46010.3TLR4, TLR2
8pam3csk46010.3TLR4, TLR2
9poly(i:c)6010.2TLR4, TLR2
10loxoribine45 2911.2TLR4, TLR2
11p 2774510.2IL10, TLR2
12aspartate4510.2IGHE, HLA-B
13resiquimod45 6011.1TLR2, TLR4
14glycolipid4510.1TLR4, TLR2, HLA-B
15phycoerythrin4510.1HLA-B, IL2RA
16poly(i-c)4510.1IL12B, TLR2, TLR4
17bifidobacterium4510.1IL10, TLR2
18muramyl dipeptide45 2911.1TLR4, TLR2
195 aminosalicylic acid4510.0IL2RA, IL10, IL12B
20pneumococcal4510.0HLA-B, TLR4
21glucuronoxylomannan4510.0IL10, TLR2, TLR4
22polymyxin b4510.0TLR4, TLR2, IL10
23cyclosporin a45 29 6011.9HLA-B, IGHE, IL2RA
242,5-oligoadenylate459.9TLR4, HLA-B, IL2RA, IL10
25ccl345 2910.8TLR4, TLR2, IL10
26ifn-alpha459.8TAP1, IL10, IL2RA, TLR4
27imiquimod45 29 60 1112.8TLR4, TLR2, IL10, IL12B
28heroin45 50 1111.8IGHE, IL10, CES2
29peptidoglycan45 2910.8TLR4, TLR2, IL10, IL12B
30dexamethasone45 50 29 1112.8TLR4, TLR2, IGHE
31montelukast45 50 29 1112.7IGHE, IL2RA, IL10
32h2o2459.7IL2RA, PRDX4
33rantes459.7TLR4, TLR2, HLA-B, IL2RA, IL12B
34calcitriol45 60 11 2412.7IL10, IL2RA, TLR2, TLR4
35lipoteichoic acid459.6IL12B, IL10, HLA-B, TLR2, TLR4
36polyinosinic-polycytidylic acid459.6TLR4, TLR2, HLA-B, IL10, IL12B
37latex459.6IGHE, HLA-B, TLR2, TLR4
38ivig459.6IL10, IL2RA, IGHE
39il 10459.6TLR4, TLR2, IL2RA, IL10, IL12B
40infliximab45 50 1111.5TLR4, IGHE, IL2RA, IL10
41chloroquine45 2 50 29 1113.5IL10, IL2RA, TLR4
42allergens459.4IL10, IGHE, HLA-DRB1, TLR4
43sb 20358045 6010.4TLR4, TLR2, IL10, IL12B
44polysaccharide459.4IL2RA, IGHE, HLA-B, TLR2, TLR4
45glutamine459.3TLR2, HLA-DQB1, IGHE, TAP1, TAP2
46methotrexate45 50 1111.3HLA-DRB1, IGHE, IL2RA, IL10
47histamine45 29 2411.2TLR4, TLR2, IGHE, IL2RA, IL10
48vitamin d459.0TLR4, TLR2, IGHE, IL2RA, IL10, IL12B
49atp45 299.9TLR4, TLR2, HLA-B, HLA-DRB1, MT-ATP6, MT-CO1
50alanine458.9TLR4, TLR2, HLA-DRB1, IGHE, TAP1, TAP2

GO Terms for genes affiliated with Cystic Echinococcosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cystic Echinococcosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.0TAP1, TAP2
2integral to lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-B, HLA-DQB1
3ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-B, HLA-DQB1
4eukaryotic translation elongation factor 1 complexGO:0058539.5EEF1D, EEF1B2
5external side of plasma membraneGO:0098979.4IL2RA, HLA-DRB1, TLR2, TLR4

Biological processes related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.4TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.4TAP2, TAP1
3peptide transportGO:01583310.4TAP1, TAP2
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP1, TAP2
5positive regulation of macrophage cytokine productionGO:06090710.2TLR4, TLR2
6cellular response to lipoteichoic acidGO:07122310.2TLR4, TLR2
7I-kappaB phosphorylationGO:00725210.1TLR4, TLR2, PRDX4
8immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.1HLA-DQB1, HLA-DRB1
9positive regulation of MHC class II biosynthetic processGO:04534810.1TLR4, IL10
10negative regulation of interleukin-17 productionGO:03270010.1IL12B, TLR2, TLR4
11positive regulation of NF-kappaB import into nucleusGO:04234610.1IL12B, TLR2, TLR4
12positive regulation of interleukin-12 productionGO:03273510.1IL12B, TLR2, TLR4
13T-helper 1 type immune responseGO:04208810.1IL12B, HLA-DRB1, TLR4
14positive regulation of T cell mediated cytotoxicityGO:00191610.0TAP2, TAP1, IL12B, HLA-B
15positive regulation of tumor necrosis factor productionGO:03276010.0IL12B, TLR2, TLR4
16positive regulation of inflammatory responseGO:05072910.0TLR4, TLR2, IL12B
17humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DRB1, HLA-DQB1
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0HLA-B, TAP1, TAP2
19positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, TLR2
20negative regulation of growth of symbiont in hostGO:04413010.0TLR2, IL10, IL12B
21antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.0TAP2, TAP1, HLA-B
22positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR2, TLR4
23negative regulation of interferon-gamma productionGO:0326899.9TLR4, HLA-DRB1, IL10
24interferon-gamma-mediated signaling pathwayGO:0603339.9HLA-DRB1, HLA-B, HLA-DQB1
25inflammatory response to antigenic stimulusGO:0024379.9IL2RA, HLA-DRB1
26negative regulation of T cell proliferationGO:0421309.9HLA-DRB1, IL2RA, IL10
27cellular response to lipopolysaccharideGO:0712229.9TLR4, IL10, IL12B
28negative regulation of interleukin-12 productionGO:0326959.7IL10, TLR2
29antigen processing and presentation of peptide antigen via MHC class IGO:0024749.6HLA-B, TAP1, TAP2
30immune responseGO:0069558.7TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, IGHE

Molecular functions related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.2TAP1, TAP2
2peptide transporter activityGO:01519710.2TAP1, TAP2
3TAP2 bindingGO:04697910.2TAP1, TAP2
4TAP1 bindingGO:04697810.1TAP1, TAP2
5oligopeptide-transporting ATPase activityGO:01542110.1TAP1, TAP2
6MHC class I protein bindingGO:04228810.1TAP2, TAP1
7lipopolysaccharide receptor activityGO:0018759.8TLR2, TLR4
8peptide antigen bindingGO:0426059.8TAP2, TAP1, HLA-DRB1, HLA-B
9MHC class II receptor activityGO:0323959.6HLA-DRB1, HLA-DQB1

Products for genes affiliated with Cystic Echinococcosis

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Sources for Cystic Echinococcosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet