MCID: CYS008
MIFTS: 48

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 66UMLS, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 11 13 52
Echinococcus Granulosus Infection 11 66
Echinococcus Granulosus Infectious Disease of Thyroid 11
Echinococcus Granulosus Infectious Disease of Liver 11
Echinococcus Granulosus Infection, Unspecified 11
Echinococcus Granulosus Infection of Thyroid 11
Echinococcus Granulosus Infectious Disease 11
Echinococcus Granulosus Infection of Lung 11
Unspecified Echinococcus Granulosus 11
 
Thyroid Echinococcus Granulosus 11
Liver Echinococcus Granulosus 11
Lung Echinococcus Granulosus 11
Unilocular Hydatid Disease 11
Unilocular Echinococcosis 11
Hydatid Disease 52
Echinococcosis 66
Hydatidosis 52

Characteristics:

Orphanet epidemiological data:

52
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:1495
ICD9CM30 122.4
Orphanet52 ORPHA400
SNOMED-CT60 187138004, 75006000
ICD10 via Orphanet29 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
MESH via Orphanet38 D004443
UMLS via Orphanet67 C0013502

Summaries for Cystic Echinococcosis

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Disease Ontology:11 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to echinococcosis and ovarian papillary cystadenoma, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are Cytokines and Inflammatory Response and G-protein signaling_RhoB regulation pathway. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

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Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis11.5
2ovarian papillary cystadenoma10.7HLA-DRB1, IL10
3hypertrophic or verrucous lupus erythematosus10.7HLA-DRB1, IL10
4thelaziasis10.7IL10, MT-ATP6
5panuveitis10.6HLA-DRB1, IL10
6peripheral t-cell lymphoma10.6HLA-DRB1, IL10
7hernia of ovary and fallopian tube10.6HLA-DRB1, IL10
8orbit alveolar rhabdomyosarcoma10.6HLA-DRB1, IL10
9lipodermatosclerosis10.6HLA-DRB1, IL10
10nebulin-related early-onset distal myopathy10.6HLA-DRB1, IL17A
11chronic polyneuropathy10.6HLA-DRB1, IL17A
12idiopathic central precocious puberty10.6HLA-DRB1, IL10
13sensorineural hearing loss10.6HLA-DRB1, IL10
14epididymo-orchitis10.6IL10, IL17A
15mastocytosis cutaneous with short stature conductive hearing loss and microtia10.6HLA-DRB1, IL10
16hemophagocytic lymphohistiocytosis10.6HLA-DRB1, IL10
17potato nose10.6HLA-DRB1, TLR2
18polyradiculoneuropathy10.5IL10, IL17A
19newborn respiratory distress syndrome10.5HLA-DRB1, IL17A
20arachnoiditis10.5HLA-DRB1, MT-CO1
21proximal symphalangism10.5HLA-DRB1, IL10
22hepatitis10.5
23decubitus ulcer10.5IL10, TLR2
24toxocariasis10.5IL17A, TLR2
25conventional leiomyosarcoma10.5CD40LG, HLA-DRB1
26balkan hemorrhagic fever10.5CD40LG, IL10
27accessory nerve disease10.5IL10, TLR2
28askin's tumor10.5IL10, TLR2
29tetanus neonatorum10.5IL10, IL17A
30hypospadias10.5IL10, TLR2
31gastroduodenal crohn's disease10.4IL17A, TLR2
32night blindness10.4CD40LG, IL17A
33spastic monoplegia10.4CD40LG, IL10
34vestibule of mouth cancer10.4CD40LG, IL17A
35malignant eyelid melanoma10.4CD40LG, IL17A
36fibrous histiocytoma10.4CD40LG, HLA-DRB1
37pneumonic tularemia10.4CD40LG, IL10
38rickettsialpox10.4CD40LG, TLR2
39hepatic vein thrombosis10.4CD40LG, TLR2
40leukostasis10.4CD40LG, IL10
41smooth muscle tumor10.3HLA-DRB1, IL10, IL17A
42renovascular hypertension10.3CD40LG, HLA-DRB1
43orbital periostitis10.3IL10, IL17A
44congenital nystagmus10.3CD40LG, MT-CO1
45kernicterus10.3HLA-DRB1, IL10, IL17A
46abducens nerve neoplasm10.3CD40LG, TLR2
47chronic apical periodontitis10.3CD40LG, HLA-DRB1
48corneal intraepithelial neoplasm10.3IL10, IL17A
49inner ear cancer10.3CD40LG, TLR2
50tick-borne encephalitis10.3CD40LG, IL17A

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

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HPO human phenotypes related to Cystic Echinococcosis:

(show all 37)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 urticaria typical (50%) HP:0001025
6 hepatomegaly typical (50%) HP:0002240
7 abnormality of temperature regulation typical (50%) HP:0004370
8 impaired temperature sensation typical (50%) HP:0010829
9 biliary tract neoplasm typical (50%) HP:0100574
10 hydrocephalus occasional (7.5%) HP:0000238
11 visual impairment occasional (7.5%) HP:0000505
12 proptosis occasional (7.5%) HP:0000520
13 seizures occasional (7.5%) HP:0001250
14 cirrhosis occasional (7.5%) HP:0001394
15 portal hypertension occasional (7.5%) HP:0001409
16 ascites occasional (7.5%) HP:0001541
17 splenomegaly occasional (7.5%) HP:0001744
18 abnormality of eosinophils occasional (7.5%) HP:0001879
19 esophageal varix occasional (7.5%) HP:0002040
20 migraine occasional (7.5%) HP:0002076
21 respiratory insufficiency occasional (7.5%) HP:0002093
22 abnormality of the pleura occasional (7.5%) HP:0002103
23 hemoptysis occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
25 vertigo occasional (7.5%) HP:0002321
26 increased intracranial pressure occasional (7.5%) HP:0002516
27 hypotension occasional (7.5%) HP:0002615
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
31 acute hepatic failure occasional (7.5%) HP:0006554
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 liver abscess occasional (7.5%) HP:0100523
36 chronic hepatic failure occasional (7.5%) HP:0100626
37 sepsis occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS66/NDF-RT44:

Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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MalaCards organs/tissues related to Cystic Echinococcosis:

34
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes

Animal Models for Cystic Echinococcosis or affiliated genes

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Publications for Cystic Echinococcosis

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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 479)
idTitleAuthorsYear
1
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. (27273641)
2016
2
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. (27091868)
2016
3
Cystic echinococcosis in Southern Israel. (26751890)
2016
4
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
5
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis. (25566682)
2015
6
Open Conservative Surgical Management of Cystic Echinococcosis in a Tertiary Care Hospital, Nepal. (26393161)
2015
7
Cystic Echinococcosis Seropositivity in the Blood Samples Sent to Parasitology Laboratory of YA1zA1ncA1 YA+l University Medical Faculty between 2005 and 2013: Retrospective Assessment. (26470927)
2015
8
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
9
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
10
Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum. (25706429)
2014
11
Evaluation of purified antigen fraction in the immunodiagnosis of cystic echinococcosis. (24828349)
2014
12
Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012. (25149351)
2014
13
Diagnostics in cystic echinococcosis: serology versus ultrasonography. (25254522)
2014
14
Molecular diagnosis of cystic echinococcosis in humans from central Poland. (23535071)
2013
15
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
16
Cystic echinococcosis in South Africa: the worst yet to come? (23774317)
2013
17
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
18
Cystic echinococcosis in sheep in Sardinia. Changing pattern and present status. (22178675)
2012
19
Critical analysis of cystic echinococcosis control programs and praziquantel use in South America, 1974-2010. (22427169)
2012
20
Prevalence and diversity of cystic echinococcosis in livestock in Maasailand, Kenya. (22915272)
2012
21
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
22
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
23
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
24
Programme for ultrasound diagnoses and treatment with albendazole of cystic echinococcosis in asymptomatic carriers: 10 years of follow-up of cases. (20832386)
2011
25
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China. (22039558)
2011
26
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
27
Chemotherapy and surgery in children with cystic echinococcosis. (20574405)
2010
28
Cystic echinococcosis in Greece. Past and present. (21073143)
2010
29
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
30
Magnetic resonance appearance of cerebral cystic echinococcosis: World Health Organization (WHO) classification. (19455447)
2009
31
Autochthonous cystic echinococcosis in patients who grew up in Germany. (19497251)
2009
32
Molecular update on cystic echinococcosis in cattle and water buffaloes of southern Italy. (18234031)
2008
33
Post-surgical follow-up (by ELISA and immunoblotting) of cured versus non-cured cystic echinococcosis in young patients. (17767795)
2008
34
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
35
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
36
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
37
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
38
Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis. (16218215)
2005
39
A discrepancy between cystic echinococcosis confirmed by ultrasound and seropositivity in Turkish children. (15652335)
2005
40
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
41
Cystic echinococcosis in the Berber of the Mid Atlas mountains, Morocco: new insights into the natural history of the disease in humans. (15257798)
2004
42
Classification, follow-up and recurrence of hepatic cystic echinococcosis using ultrasound images. (14584379)
2003
43
Molecular and cellular tools in human cystic echinococcosis. (12476488)
2002
44
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. (11116435)
2000
45
A new therapeutic approach for the treatment of cystic echinococcosis: percutaneous albendazole sulphoxide injection without reaspiration. (10638592)
2000
46
Editorial response: Treatment of cystic echinococcosis--improving but still limited. (10476733)
1999
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
Principles of the surgical approach in human liver cystic echinococcosis. (9095292)
1997
49
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
50
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989

Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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GO Terms for genes affiliated with Cystic Echinococcosis

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Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.9CD40LG, CES1, CES2, IL10, IL17A

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:004210010.1CD40LG, IL10
2positive regulation of interleukin-12 productionGO:003273510.0CD40LG, TLR2
3positive regulation of interleukin-10 productionGO:003273310.0CD40LG, TLR2
4agingGO:00075689.5IL10, MT-ATP6, MT-CO1
5inflammatory responseGO:00069548.8CD40LG, IL10, IL17A, TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1methylumbelliferyl-acetate deacetylase activityGO:00473749.5CES1, CES2
2carboxylic ester hydrolase activityGO:00526899.4CES1, CES2
3cytokine activityGO:00051259.3CD40LG, IL10, IL17A

Sources for Cystic Echinococcosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet