MCID: CYS008
MIFTS: 44

Cystic Echinococcosis

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

MalaCards integrated aliases for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 56 14
Echinococcus Granulosus Infection 12 69
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection, Unspecified 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Echinococcus Granulosus Infection of Lung 12
Unspecified Echinococcus Granulosus 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 56
Echinococcosis 69
Hydatidosis 56

Characteristics:

Orphanet epidemiological data:

56
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 35 122.4
SNOMED-CT 64 187138004 75006000
Orphanet 56 ORPHA400
MESH via Orphanet 43 D004443
UMLS via Orphanet 70 C0013502
UMLS 69 C0152068

Summaries for Cystic Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to echinococcosis and aseptic meningitis. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Immune response NFAT in immune response and Th17 cell differentiation. The drugs Metronidazole and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

Related Diseases for Cystic Echinococcosis

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 echinococcosis 11.7
2 aseptic meningitis 10.6 HLA-DRB1 MT-CO1
3 thelaziasis 10.6 IL10 MT-ATP6
4 aids wasting syndrome 10.6 HLA-DRB1 IL10
5 neutrophil-specific granule deficiency 10.5 IL10 IL17A
6 fruit allergy 10.5 HLA-DQB1 HLA-DRB1
7 breast hemangiopericytoma 10.5 HLA-DQB1 HLA-DRB1
8 tonsil cancer 10.5 IL10 MT-CO1
9 balkan hemorrhagic fever 10.5 CD40LG IL10
10 biemond syndrome 10.5 HLA-DQB1 HLA-DRB1
11 light chain deposition disease 10.5 HLA-DQB1 HLA-DRB1
12 juvenile sialidosis type 2 10.5 HLA-DQB1 HLA-DRB1
13 idiopathic subglottic tracheal stenosis 10.5 HLA-DQB1 HLA-DRB1
14 reese retinal dysplasia 10.5 HLA-DQB1 HLA-DRB1
15 mosaic trisomy 1 10.5 HLA-DQB1 HLA-DRB1
16 autoimmune retinopathy 10.5 HLA-DQB1 HLA-DRB1
17 diabetic angiopathy 10.5 CD40LG IL10
18 progressive myoclonus epilepsy 10.5 HLA-DQB1 HLA-DRB1
19 gastric leiomyoma 10.5 CES2 MT-CO1
20 limb-body wall complex 10.5 HLA-DQB1 HLA-DRB1
21 transient retinal arterial occlusion 10.5 HLA-DQB1 HLA-DRB1
22 dumping syndrome 10.5 CD40LG IL10
23 fetal akinesia deformation sequence 10.5 CD40LG MT-CO1
24 abdominal tuberculosis 10.5 CD40LG MT-CO1
25 facial paralysis 10.5 CD40LG IL10
26 pellagra like syndrome 10.5 HLA-DQB1 HLA-DRB1
27 achilles bursitis 10.5 CD40LG MT-CO1
28 lung disease 10.5 CD40LG IL17A
29 lymphocytic colitis 10.4 HLA-DQB1 HLA-DRB1
30 centronuclear myopathy 5 10.4 CD40LG IL10
31 oculo-cerebral dysplasia 10.4 CD40LG IL17A
32 blood group incompatibility 10.4 CD40LG HLA-DRB1
33 tricho onychic dysplasia 10.4 IL10 IL17A
34 mazabraud syndrome 10.4 HLA-DQB1 HLA-DRB1
35 malignant eyelid melanoma 10.4 CD40LG IL17A
36 idiopathic dilatation of the pulmonary artery 10.4 HLA-DQB1 IL10
37 diabetic macular edema 10.4 CD40LG IL17A
38 myofascial pain syndrome 10.4 IL10 IL17A
39 hepatitis 10.4
40 acanthocephaliasis 10.4 MT-CO1 MT-ND1
41 malignant hypertension 10.4 CD40LG MT-CO1
42 oculogyric crisis 10.4 HLA-DQB1 HLA-DRB1
43 tularemia 10.4 CD40LG IL10
44 thrombophlebitis migrans 10.3 CD40LG MT-CO1
45 epidermolysis bullosa acquisita 10.3 HLA-DRB1 IL10 IL17A
46 megaloblastic anemia 10.3 CD40LG IL10
47 pedophilia 10.3 CD40LG HLA-DQB1
48 mitochondrial neurogastrointestinal encephalopathy disease 10.3 MT-ATP6 MT-ND1
49 b cell linker protein deficiency 10.3 CD40LG HLA-DQB1
50 infantile hypotonia 10.3 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

GenomeRNAi Phenotypes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 EEF1D HLA-DQB1 IL10 IL17A CD40LG
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 HLA-DQB1 IL10 IL17A CD40LG EEF1D

Drugs & Therapeutics for Cystic Echinococcosis

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018
2 Epi Cystic Hydatid Disease Peru Completed NCT00138346
3 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Cystic Echinococcosis

Anatomical Context for Cystic Echinococcosis

MalaCards organs/tissues related to Cystic Echinococcosis:

39
Liver, Thyroid, Lung, Heart, Brain, Bone, Testes

Publications for Cystic Echinococcosis

Articles related to Cystic Echinococcosis:

(show top 50) (show all 505)
id Title Authors Year
1
The clinical burden of human cystic echinococcosis in Palestine, 2010-2015. ( 28672021 )
2017
2
In vivo evaluation of the efficacy of combined albedazole-IFN-I+ treatment for cystic echinococcosis in mice. ( 27928681 )
2017
3
Complex interventional iliocaval recanalization due to plasmacytoma and cystic echinococcosis. ( 28613113 )
2017
4
Ruptured Pulmonary Cystic Echinococcosis Mimicking Tuberculosis in Childhood: A Case Report. ( 28695838 )
2017
5
Prevalence of cystic echinococcosis in Iran: a systematic review and meta-analysis. ( 28589871 )
2017
6
Cystic Echinococcosis in Turkana, Kenya: The Role of Cross-Sectional Screening Surveys in Assessing the Prevalence of Human Infection. ( 28722634 )
2017
7
Cystic Echinococcosis: A Rare Case of Brain Localization. ( 28761474 )
2017
8
The disease burden of human cystic echinococcosis based on HDRs from 2001 to 2014 in Italy. ( 28746395 )
2017
9
Proteomic investigation of human cystic echinococcosis in the liver. ( 27986452 )
2017
10
Teaching NeuroImages: Giant cystic echinococcosis with unusual imaging manifestations. ( 28583941 )
2017
11
Prevalence and Risk Factors for Human Cystic Echinococcosis in the Cusco Region of the Peruvian Highlands Diagnosed Using Focused Abdominal Ultrasound. ( 28719254 )
2017
12
Knowledge, attitudes, and practices regarding cystic echinococcosis and sheep herding in Peru: a mixed-methods approach. ( 28683741 )
2017
13
Cystic echinococcosis in cattle dairy farms: spatial distribution and epidemiological dynamics. ( 28555485 )
2017
14
Cystic echinococcosis in South America: a call for action. ( 28902268 )
2017
15
The non-resolving lung cavity: a case of pulmonary cystic echinococcosis. ( 28765482 )
2017
16
Recurrence of cystic echinococcosis in an endemic area: a retrospective study. ( 28655301 )
2017
17
Surgically managed human cystic echinococcosis in north-eastern Iran: a single center's experience from 2001 to 2008. ( 28848297 )
2017
18
Large-scale evaluation of a rapid diagnostic test for human cystic echinococcosis. ( 28647066 )
2017
19
Trends and correlates of cystic echinococcosis in Chile: 2001-2012. ( 28915247 )
2017
20
Primary echinococcus infection of the heart: a rare type of cystic echinococcosis. ( 28499031 )
2017
21
Expert Reliability for the World Health Organization Standardized Ultrasound Classification of Cystic Echinococcosis. ( 28070008 )
2017
22
Knowledge, attitudes and practices towards cystic echinococcosis in livestock among selected pastoral and agro-pastoral communities in Uganda. ( 28913591 )
2017
23
Evaluation of Patients with Cystic Echinococcosis. ( 28483731 )
2017
24
Diagnosis of cystic echinococcosis in buffaloes by native 8A kDa antigen using latex agglutination test (LAT). ( 27876957 )
2016
25
The first meeting of the European Register of Cystic Echinococcosis (ERCE). ( 27126135 )
2016
26
Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis. ( 27023205 )
2016
27
Sero-epidemiological value of some hydatid cyst antigen in diagnosis of human cystic echinococcosis. ( 27065597 )
2016
28
Bayesian spatial analysis of the surgical incidence rate of human cystic echinococcosis in north-eastern Iran. ( 27496620 )
2016
29
Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice. ( 27605805 )
2016
30
Investigation of the use of serology and ultrasonography to detect hepatic cystic echinococcosis in Heilongjiang, China, using a Bayesian framework. ( 27412377 )
2016
31
Treatment of Hepatic Cystic Echinococcosis in Patients from the Southeastern Rhodope Region of Bulgaria in 2004-2013: Comparison of Current Practices with Expert Recommendations. ( 26834196 )
2016
32
Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune-evasion strategy? ( 27120498 )
2016
33
Cutaneous Disease as the First Manifestation of Cystic Echinococcosis. ( 27489329 )
2016
34
Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans. ( 26871432 )
2016
35
Abdominal Cystic Echinococcosis Treated with Albendazole. A Pediatric Cohort Study. ( 27589236 )
2016
36
Cystic echinococcosis: Future perspectives of molecular epidemiology. ( 27237060 )
2016
37
Cystic echinococcosis in Southern Israel. ( 26751890 )
2016
38
Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis. ( 27820824 )
2016
39
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. ( 27273641 )
2016
40
Gene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis. ( 27467147 )
2016
41
Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial. ( 26825878 )
2016
42
A study of morphological aspects of cystic echinococcosis in sheep in Sardinia. ( 27060775 )
2016
43
First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". ( 27624561 )
2016
44
ZOONOTIC ENCOUNTERS AT THE SLAUGHTERHOUSE: PATHWAYS AND POSSIBILITIES FOR THE CONTROL OF CYSTIC ECHINOCOCCOSIS IN NORTHERN MOROCCO. ( 27428068 )
2016
45
Retrospective study of human cystic echinococcosis over the past decade in France, using a nationwide hospital medical information database. ( 27473835 )
2016
46
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. ( 27091868 )
2016
47
The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study. ( 27830083 )
2016
48
Percutaneous Treatment of Splenic Cystic Echinococcosis: Results of 12 Cases. ( 26676108 )
2016
49
The intermediate host immune response in cystic echinococcosis. ( 26683283 )
2016
50
Antibody profiling in ultrasound normal individuals with positive serology for cystic echinococcosis. ( 26729409 )
2016

Variations for Cystic Echinococcosis

Expression for Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for Cystic Echinococcosis

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 CD40LG HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.21 HLA-DQB1 HLA-DRB1 IL10 IL17A
3
Show member pathways
12.09 CD40LG HLA-DQB1 HLA-DRB1 IL10 IL17A
4 11.99 HLA-DQB1 HLA-DRB1 IL10
5 11.89 HLA-DQB1 HLA-DRB1 IL10
6 11.77 CD40LG HLA-DQB1 HLA-DRB1
7
Show member pathways
11.48 HLA-DQB1 HLA-DRB1
8 11.45 HLA-DQB1 HLA-DRB1 IL17A
9
Show member pathways
11.2 CD40LG HLA-DQB1 HLA-DRB1 IL10
10 11.08 HLA-DQB1 HLA-DRB1 IL10
11 10.97 HLA-DRB1 IL10
12 10.88 CD40LG IL10 IL17A
13 10.16 CES1 CES2

GO Terms for Cystic Echinococcosis

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.54 IL10 MT-ATP6 MT-CO1
2 negative regulation of T cell proliferation GO:0042130 9.46 HLA-DRB1 IL10
3 B cell proliferation GO:0042100 9.43 CD40LG IL10
4 T cell costimulation GO:0031295 9.43 CD40LG HLA-DQB1 HLA-DRB1
5 negative regulation of interferon-gamma production GO:0032689 9.4 HLA-DRB1 IL10
6 immune response GO:0006955 9.35 CD40LG HLA-DQB1 HLA-DRB1 IL10 IL17A
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DQB1 HLA-DRB1
8 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
9 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CD40LG IL10 IL17A
2 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
3 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
4 methylumbelliferyl-acetate deacetylase activity GO:0047374 8.62 CES1 CES2

Sources for Cystic Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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