MCID: CYS008
MIFTS: 46

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

About this section
Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 10 12 51
Echinococcus Granulosus Infection 10 65
Echinococcus Granulosus Infectious Disease of Thyroid 10
Echinococcus Granulosus Infectious Disease of Liver 10
Echinococcus Granulosus Infection, Unspecified 10
Echinococcus Granulosus Infection of Thyroid 10
Echinococcus Granulosus Infectious Disease 10
Echinococcus Granulosus Infection of Lung 10
Unspecified Echinococcus Granulosus 10
 
Thyroid Echinococcus Granulosus 10
Liver Echinococcus Granulosus 10
Lung Echinococcus Granulosus 10
Unilocular Hydatid Disease 10
Unilocular Echinococcosis 10
Hydatid Disease 51
Echinococcosis 65
Hydatidosis 51

Characteristics:

Orphanet epidemiological data:

51
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:1495
ICD9CM29 122.4
Orphanet51 400
SNOMED-CT59 187138004, 75006000
ICD10 via Orphanet28 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more
MESH via Orphanet37 D004443
UMLS via Orphanet66 C0013502
UMLS65 C0152068

Summaries for Cystic Echinococcosis

About this section
Disease Ontology:10 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to lateral sclerosis and bronchopulmonary dysplasia, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-ATP6 (Mitochondrially Encoded ATP Synthase 6), and among its related pathways are Staphylococcus aureus infection and Cytokines and Inflammatory Response. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

About this section

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 338)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis30.3HLA-DRB1, IL10
2bronchopulmonary dysplasia30.1IL10, IL17A
3echinococcosis28.1CES1, CES2, EEF1D, HLA-DRB1, IL10, IL17A
4leukemia10.5
5maculopapular lupus rash10.3HLA-DRB1, IL10
6drug-induced mental disorder10.3HLA-DRB1, IL10
7lymphoma10.3
8nut allergy10.3HLA-DRB1, IL10
9hypercementosis10.3HLA-DRB1, IL10
10moderately severe hemophilia a10.3HLA-DRB1, IL10
11jacobsen syndrome10.3
12finnish upper limb-onset distal myopathy10.3HLA-DRB1, IL17A
13cytoplasmic body myopathy10.3HLA-DRB1, IL10
14hemorrhagic proctocolitis10.3HLA-DRB1, IL10
15idiopathic spinal cord herniation10.3HLA-DRB1, IL10
16obesity10.3
17prostatitis10.3
18progressive relapsing multiple sclerosis10.3HLA-DRB1, IL10
19neutropenia10.3HLA-DRB1, IL17A
20prostate cancer10.3
21breast cancer10.3
22lymphocytic choriomeningitis10.3HLA-DRB1, MT-CO1
23intrahepatic gall duct cancer10.2HLA-DRB1, IL17A
24dioctophymiasis10.2IL10, MT-CO1
25atherosclerosis10.2
26hepatitis10.2
27myeloma10.2
28cervicitis10.2
29adenocarcinoma10.2
30pancreatitis10.2
31neuronitis10.2
32cardiomyopathy10.2
33meige syndrome10.2IL10, IL17A
34vernal conjunctivitis10.2IL10, IL17A
35acute orbital inflammation10.2IL10, IL17A
36alcoholic cardiomyopathy10.2MT-ATP6, MT-CO1
37rheumatoid arthritis10.1
38lung cancer10.1
39multiple myeloma10.1
40pancreatic cancer10.1
41arthritis10.1
42cerebritis10.1
43hemorrhagic fever10.1
44ataxia10.1
45endotheliitis10.1
46mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes10.1MT-ATP6, MT-ND1
47mitochondrial disorders10.1MT-ATP6, MT-ND1
48food allergy10.1IL10, IL17A
49kohler's disease10.1IL10, IL17A
50necatoriasis10.1IL10, MT-CO1

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

About this section

Symptoms:

 51 (show all 44)
  • pruritus/itching
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • polycystic liver disease/hepatic cysts
  • hepatitis/icterus/cholestasis
  • urticaria
  • hepatomegaly/liver enlargement (excluding storage disease)
  • extrahepatic biliary tract/gallbladder neoplasm/tumor/carcinoma/cancer
  • fever/chilling
  • hot flushes/sensation of cold
  • proptosis/exophthalmos
  • visual loss/blindness/amblyopia
  • dizziness
  • anomalies of spine, vertebrae and pelvis
  • anomalies of skin, subcutaneous tissue and mucosae
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • ascitis
  • esophageal varices
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • biliary/gallbladder stones/lithiasis/cholecystitis
  • cirrhosis
  • acute hepatic failure
  • chronic hepatic failure
  • liver/hepatic abscess
  • portal hypertension
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • hemoptysis
  • hypotension
  • hydrocephaly
  • cranial nerves palsy
  • facial pain/cephalalgia/migraine
  • cranial hypertension
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • seizures/epilepsy/absences/spasms/status epilepticus
  • muscle anomalies
  • osteolysis/osteoclasia/bone destruction/erosions
  • bone cyst
  • severe allergic reaction/atopy
  • eosinophils anomalies/hypereosinophilia
  • early death/lethality
  • sepsis severe/septicemia

HPO human phenotypes related to Cystic Echinococcosis:

(show all 37)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 nausea and vomiting hallmark (90%) HP:0002017
3 abdominal pain hallmark (90%) HP:0002027
4 cystic liver disease hallmark (90%) HP:0006706
5 urticaria typical (50%) HP:0001025
6 hepatomegaly typical (50%) HP:0002240
7 abnormality of temperature regulation typical (50%) HP:0004370
8 impaired temperature sensation typical (50%) HP:0010829
9 biliary tract neoplasm typical (50%) HP:0100574
10 hydrocephalus occasional (7.5%) HP:0000238
11 visual impairment occasional (7.5%) HP:0000505
12 proptosis occasional (7.5%) HP:0000520
13 seizures occasional (7.5%) HP:0001250
14 cirrhosis occasional (7.5%) HP:0001394
15 portal hypertension occasional (7.5%) HP:0001409
16 ascites occasional (7.5%) HP:0001541
17 splenomegaly occasional (7.5%) HP:0001744
18 abnormality of eosinophils occasional (7.5%) HP:0001879
19 esophageal varix occasional (7.5%) HP:0002040
20 migraine occasional (7.5%) HP:0002076
21 respiratory insufficiency occasional (7.5%) HP:0002093
22 abnormality of the pleura occasional (7.5%) HP:0002103
23 hemoptysis occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
25 vertigo occasional (7.5%) HP:0002321
26 increased intracranial pressure occasional (7.5%) HP:0002516
27 hypotension occasional (7.5%) HP:0002615
28 osteolysis occasional (7.5%) HP:0002797
29 abnormality of the musculature occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
31 acute hepatic failure occasional (7.5%) HP:0006554
32 cranial nerve paralysis occasional (7.5%) HP:0006824
33 bone cyst occasional (7.5%) HP:0012062
34 immunologic hypersensitivity occasional (7.5%) HP:0100326
35 liver abscess occasional (7.5%) HP:0100523
36 chronic hepatic failure occasional (7.5%) HP:0100626
37 sepsis occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

About this section

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS65/NDF-RT43:

Genetic Tests for Cystic Echinococcosis

About this section

Anatomical Context for Cystic Echinococcosis

About this section

MalaCards organs/tissues related to Cystic Echinococcosis:

33
Liver, Thyroid, Lung, Bone, Brain, Heart, Skin

Animal Models for Cystic Echinococcosis or affiliated genes

About this section

Publications for Cystic Echinococcosis

About this section

Articles related to Cystic Echinococcosis:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
The Author's Response: Impact of Implementation of an Automated Liquid Culture System on the Diagnosis of Tuberculous Pleurisy. (27099883)
2015
2
Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy. (26788030)
2015
3
Adiponectin receptor 1 (ADIPOR1) rs1342387 polymorphism and risk of cancer: a meta-analysis. (25292021)
2014
4
Follow-up of serum KL-6 lung fibrosis biomarker levels in 173 patients with systemic sclerosis. (24773853)
2014
5
SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML. (23558523)
2013
6
Epidemiologic features and risk factors of Crimean-Congo hemorrhagic fever in Samsun province, Turkey. (23208513)
2013
7
The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks. (23290928)
2013
8
hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. (23322088)
2013
9
Association of the ACE-II genotype with the risk of nephrotic syndrome in Pakistani children. (22033511)
2012
10
Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease. (23251365)
2012
11
Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003. (22363068)
2012
12
Podocalyxin expression in renal tissues and correlation with the number of urinary podocytes in children with Henoch-Schonlein purpura nephritis. (22561433)
2012
13
A practical method for reducing blindness due to retinopathy of prematurity in a developing country. (22945278)
2012
14
Performance of plasma fractionated free metanephrines by enzyme immunoassay in the diagnosis of pheochromocytoma and paraganglioma. (21742610)
2011
15
The effects of Robotic-Assisted Locomotor training on spasticity and volitional control. (22275643)
2011
16
Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. (21450329)
2011
17
Desmoid-type chest wall fibromatosis. A six cases series. (21239240)
2011
18
Critical role of G(alpha)12 and G(alpha)13 for human small cell lung cancer cell proliferation in vitro and tumor growth in vivo. (20160064)
2010
19
Discoid lupus erythematosus: a profile. (20642962)
2010
20
Familial nonmedullary thyroid carcinoma-clinical relevance and prognosis. A European multicenter study. ESES Vienna presentation. (20683623)
2010
21
Two novel D151Y and M391T LDLR mutations causing LDLR transport defects in Thai patients with familial hypercholesterolemia. (20599862)
2010
22
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)
2010
23
Hermansky-Pudlak syndrome. (20214008)
2009
24
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. (19368795)
2009
25
Functional reconstitution of the human serotonin receptor 5-HT(6) using synthetic transmembrane peptides. (19836355)
2009
26
Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886). (18683056)
2009
27
Generation of CA125-specific cytotoxic T lymphocytes in human leukocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer. (18976739)
2009
28
Cystic fibrosis transmembrane conductance regulator mutation spectrum in patients with cystic fibrosis in Tunisia. (19715466)
2009
29
Drosophila RecQ4 has a 3'-5' DNA helicase activity that is essential for viability. (19759018)
2009
30
Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. (18065760)
2008
31
PEG10 is a c-MYC target gene in cancer cells. (16423995)
2006
32
The role of BETA2/NeuroD1 in the development of the nervous system. (15247487)
2004
33
Blood pressure in children and adolescents with congenital adrenal hyperplasia (21-hydroxylase deficiency): a preliminary report. (12699440)
2003
34
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. (12086850)
2002
35
Gamma-glutamyltransferase, alcohol, and blood pressure. A four year follow-up study. (11880216)
2002
36
Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia. (11321887)
2001
37
Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). (11529629)
2001
38
Signaling pathways initiated in macrophages after engagement of type A scavenger receptors. (11435497)
2001
39
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. (8643682)
1996
40
Electrophysiological studies in patients with blepharospasm before and after botulinum toxin A therapy. (8926500)
1996
41
Increased incidence and severity of Streptococcus pyogenes bacteremia in young children. (8559625)
1995
42
Hepoxilins. (8224734)
1993
43
Cloning and functional characterization of a human A1 adenosine receptor. (1530647)
1992
44
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. (1718794)
1991
45
Cerebral atrophy and neuropsychological correlates in schizophrenia. (3452986)
1987
46
Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II. (6090207)
1984
47
The incidence of premenstrual tension in a gynecologic clinic. (6891720)
1982
48
Osteochondrosis in six breeds of slaughter pigs. (22039857)
1980
49
Giant keratoacanthoma of the ear. (595076)
1977
50

Variations for Cystic Echinococcosis

About this section

Expression for genes affiliated with Cystic Echinococcosis

About this section
Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

About this section

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8HLA-DRB1, IL10
29.8HLA-DRB1, IL10
39.0CES1, CES2

GO Terms for genes affiliated with Cystic Echinococcosis

About this section

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069559.3HLA-DRB1, IL10, IL17A

Sources for Cystic Echinococcosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet