MCID: CYS008
MIFTS: 50

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

About this section
Sources:
11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 39MESH via Orphanet, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 11 53 13
Echinococcus Granulosus Infection 11 67
Echinococcus Granulosus Infectious Disease of Thyroid 11
Echinococcus Granulosus Infectious Disease of Liver 11
Echinococcus Granulosus Infection, Unspecified 11
Echinococcus Granulosus Infection of Thyroid 11
Echinococcus Granulosus Infectious Disease 11
Echinococcus Granulosus Infection of Lung 11
Unspecified Echinococcus Granulosus 11
 
Thyroid Echinococcus Granulosus 11
Liver Echinococcus Granulosus 11
Lung Echinococcus Granulosus 11
Unilocular Hydatid Disease 11
Unilocular Echinococcosis 11
Hydatid Disease 53
Echinococcosis 67
Hydatidosis 53

Characteristics:

Orphanet epidemiological data:

53
cystic echinococcosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult

Classifications:



External Ids:

Disease Ontology11 DOID:1495
ICD9CM31 122.4
Orphanet53 ORPHA400
SNOMED-CT61 187138004, 75006000
MESH via Orphanet39 D004443
UMLS via Orphanet68 C0013502
ICD10 via Orphanet30 B67.0, B67.1, B67.2 B67.3, B67.4, B67.5, B67.6, B67.7, B67.8, B67.9, more

Summaries for Cystic Echinococcosis

About this section
Disease Ontology:11 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to echinococcosis and ovarian papillary cystadenoma, and has symptoms including pruritus, nausea and vomiting and abdominal pain. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways are IL-10 Pathway and African trypanosomiasis. The drug albendazole has been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and lung.

Related Diseases for Cystic Echinococcosis

About this section

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis11.7
2ovarian papillary cystadenoma10.5HLA-DRB1, IL10
3arachnoiditis10.5HLA-DRB1, MT-CO1
4hypertrophic or verrucous lupus erythematosus10.5HLA-DRB1, IL10
5thelaziasis10.5IL10, MT-ATP6
6panuveitis10.5HLA-DRB1, IL10
7peripheral t-cell lymphoma10.5HLA-DRB1, IL10
8hernia of ovary and fallopian tube10.5HLA-DRB1, IL10
9nebulin-related early-onset distal myopathy10.5HLA-DRB1, IL17A
10orbit alveolar rhabdomyosarcoma10.5HLA-DRB1, IL10
11lipodermatosclerosis10.5HLA-DRB1, IL10
12chronic polyneuropathy10.5HLA-DRB1, IL17A
13idiopathic central precocious puberty10.5HLA-DRB1, IL10
14sensorineural hearing loss10.5HLA-DRB1, IL10
15epididymo-orchitis10.5IL10, IL17A
16congenital nystagmus10.5CD40LG, MT-CO1
17balkan hemorrhagic fever10.4CD40LG, IL10
18kaposi sarcoma10.4HLA-DRB1, IL6
19epstein-barr virus hepatitis10.4HLA-DRB1, IL6
20abdominal chemodectomas with cutaneous angiolipomas10.4HLA-DRB1, IL6
21gastric leiomyoma10.4CES1, MT-CO1
22lymphocytic colitis10.4HLA-DRB1, IL6
23night blindness10.4CD40LG, IL17A
24african histoplasmosis10.4CD40LG, MT-CO1
25predominantly cortical thymoma10.4IL10, IL6
26hepatitis10.4
27vestibule of mouth cancer10.4CD40LG, IL17A
28malignant eyelid melanoma10.4CD40LG, IL17A
29benign adult familial myoclonic epilepsy10.4IL10, IL6
30spastic monoplegia10.4CD40LG, IL10
31infancy electroclinical syndrome10.4IL10, IL6
32ethmoid sinus adenoid cystic carcinoma10.4IL10, IL6
33tricho odonto onycho dermal syndrome10.3IL17A, IL6
34pneumonic tularemia10.3CD40LG, IL10
35fibrous histiocytoma10.3CD40LG, HLA-DRB1
36polyhydramnios10.3IL10, IL6
37herpangina10.3IL10, IL6
38malignant gastric granular cell tumor10.3IL17A, IL6
39marchiafava bignami disease10.3IL10, IL6
40monoclonal paraproteinemia10.3CD40LG, IL6
41idiopathic neutropenia10.3IL10, IL6
42orbital lymphangioma10.3IL10, IL6
43disease_ontology10.3CD40LG, IL6
44central gyrate choroidal dystrophy10.3HLA-DRB1, IL6
45potato nose10.3HLA-DRB1, TLR2
46cauda equina syndrome10.3IL10, IL6
47complex regional pain syndrome10.3IL17A, IL6
48cyclothymic disorder10.3CD40LG, IL6
49scn8a encephalopathy10.3IL10, IL6
50non-secretory myeloma10.3CD40LG, IL6

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Symptoms for Cystic Echinococcosis

About this section

Human phenotypes related to Cystic Echinococcosis:

 63 (show all 37)
id Description HPO Frequency HPO Source Accession
1 pruritus63 hallmark (90%) HP:0000989
2 nausea and vomiting63 hallmark (90%) HP:0002017
3 abdominal pain63 hallmark (90%) HP:0002027
4 cystic liver disease63 hallmark (90%) HP:0006706
5 urticaria63 typical (50%) HP:0001025
6 hepatomegaly63 typical (50%) HP:0002240
7 abnormality of temperature regulation63 typical (50%) HP:0004370
8 impaired temperature sensation63 typical (50%) HP:0010829
9 biliary tract neoplasm63 typical (50%) HP:0100574
10 hydrocephalus63 occasional (7.5%) HP:0000238
11 visual impairment63 occasional (7.5%) HP:0000505
12 proptosis63 occasional (7.5%) HP:0000520
13 seizures63 occasional (7.5%) HP:0001250
14 cirrhosis63 occasional (7.5%) HP:0001394
15 portal hypertension63 occasional (7.5%) HP:0001409
16 ascites63 occasional (7.5%) HP:0001541
17 splenomegaly63 occasional (7.5%) HP:0001744
18 abnormality of eosinophils63 occasional (7.5%) HP:0001879
19 esophageal varix63 occasional (7.5%) HP:0002040
20 migraine63 occasional (7.5%) HP:0002076
21 respiratory insufficiency63 occasional (7.5%) HP:0002093
22 abnormality of the pleura63 occasional (7.5%) HP:0002103
23 hemoptysis63 occasional (7.5%) HP:0002105
24 gastrointestinal hemorrhage63 occasional (7.5%) HP:0002239
25 vertigo63 occasional (7.5%) HP:0002321
26 increased intracranial pressure63 occasional (7.5%) HP:0002516
27 hypotension63 occasional (7.5%) HP:0002615
28 osteolysis63 occasional (7.5%) HP:0002797
29 abnormality of the musculature63 occasional (7.5%) HP:0003011
30 hemiplegia/hemiparesis63 occasional (7.5%) HP:0004374
31 acute hepatic failure63 occasional (7.5%) HP:0006554
32 cranial nerve paralysis63 occasional (7.5%) HP:0006824
33 bone cyst63 occasional (7.5%) HP:0012062
34 immunologic hypersensitivity63 occasional (7.5%) HP:0100326
35 liver abscess63 occasional (7.5%) HP:0100523
36 chronic hepatic failure63 occasional (7.5%) HP:0100626
37 sepsis63 occasional (7.5%) HP:0100806

Drugs & Therapeutics for Cystic Echinococcosis

About this section

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts3868

Interventional clinical trials:

idNameStatusNCT IDPhase
1Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the LiverCompletedNCT01643018
2Epi Cystic Hydatid Disease PeruCompletedNCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS67/NDF-RT45:

Genetic Tests for Cystic Echinococcosis

About this section

Anatomical Context for Cystic Echinococcosis

About this section

MalaCards organs/tissues related to Cystic Echinococcosis:

35
Liver, Thyroid, Lung, Bone, Heart, Brain, Testes

Animal Models for Cystic Echinococcosis or affiliated genes

About this section

Publications for Cystic Echinococcosis

About this section

Articles related to Cystic Echinococcosis:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. (27273641)
2016
2
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. (27091868)
2016
3
Cystic echinococcosis in Southern Israel. (26751890)
2016
4
Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. (26409727)
2015
5
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis. (25566682)
2015
6
Open Conservative Surgical Management of Cystic Echinococcosis in a Tertiary Care Hospital, Nepal. (26393161)
2015
7
Cystic Echinococcosis Seropositivity in the Blood Samples Sent to Parasitology Laboratory of YA1zA1ncA1 YA+l University Medical Faculty between 2005 and 2013: Retrospective Assessment. (26470927)
2015
8
A community-based study to examine the epidemiology of human cystic echinococcosis in Rio Negro Province, Argentina. (24742907)
2014
9
MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep. (24782918)
2014
10
Evaluation of human cystic echinococcosis before and after surgery and chemotherapy by demonstration of antibodies in serum. (25706429)
2014
11
Evaluation of purified antigen fraction in the immunodiagnosis of cystic echinococcosis. (24828349)
2014
12
Retrospective study of human cystic echinococcosis in Italy based on the analysis of hospital discharge records between 2001 and 2012. (25149351)
2014
13
Diagnostics in cystic echinococcosis: serology versus ultrasonography. (25254522)
2014
14
Molecular diagnosis of cystic echinococcosis in humans from central Poland. (23535071)
2013
15
A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. (23546806)
2013
16
Cystic echinococcosis in South Africa: the worst yet to come? (23774317)
2013
17
Host-parasite relationship in cystic echinococcosis: an evolving story. (22110535)
2012
18
Cystic echinococcosis in sheep in Sardinia. Changing pattern and present status. (22178675)
2012
19
Critical analysis of cystic echinococcosis control programs and praziquantel use in South America, 1974-2010. (22427169)
2012
20
Prevalence and diversity of cystic echinococcosis in livestock in Maasailand, Kenya. (22915272)
2012
21
Community survey, treatment and long-term follow-up for human cystic echinococcosis in northwest China. (22040575)
2011
22
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
23
Cystic echinococcosis in Romania: the pediatric approach. (21284521)
2011
24
Programme for ultrasound diagnoses and treatment with albendazole of cystic echinococcosis in asymptomatic carriers: 10 years of follow-up of cases. (20832386)
2011
25
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China. (22039558)
2011
26
Epidemiology and epizootology of cystic echinococcosis in Romania 1862-2007. (20156088)
2010
27
Chemotherapy and surgery in children with cystic echinococcosis. (20574405)
2010
28
Cystic echinococcosis in Greece. Past and present. (21073143)
2010
29
Evaluation of antibodies against hydatid cyst fluid antigens in the post-treatment follow-up of cystic echinococcosis patients. (19333201)
2009
30
Magnetic resonance appearance of cerebral cystic echinococcosis: World Health Organization (WHO) classification. (19455447)
2009
31
Autochthonous cystic echinococcosis in patients who grew up in Germany. (19497251)
2009
32
Molecular update on cystic echinococcosis in cattle and water buffaloes of southern Italy. (18234031)
2008
33
Post-surgical follow-up (by ELISA and immunoblotting) of cured versus non-cured cystic echinococcosis in young patients. (17767795)
2008
34
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
35
Liver cystic echinococcosis: which cysts are correlated with false negative indirect passive hemagglutination (IHA)? (17657919)
2007
36
Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis. (17335765)
2007
37
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
38
Postoperative changes in serum cytokines profile and nitric oxide levels in patients with cystic echinococcosis. (16218215)
2005
39
A discrepancy between cystic echinococcosis confirmed by ultrasound and seropositivity in Turkish children. (15652335)
2005
40
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
41
Cystic echinococcosis in the Berber of the Mid Atlas mountains, Morocco: new insights into the natural history of the disease in humans. (15257798)
2004
42
Classification, follow-up and recurrence of hepatic cystic echinococcosis using ultrasound images. (14584379)
2003
43
Molecular and cellular tools in human cystic echinococcosis. (12476488)
2002
44
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. (11116435)
2000
45
A new therapeutic approach for the treatment of cystic echinococcosis: percutaneous albendazole sulphoxide injection without reaspiration. (10638592)
2000
46
Editorial response: Treatment of cystic echinococcosis--improving but still limited. (10476733)
1999
47
T-lymphocyte cytokine mRNA expression in cystic echinococcosis. (9095287)
1997
48
Principles of the surgical approach in human liver cystic echinococcosis. (9095292)
1997
49
A retrospective study of human cystic echinococcosis in Jordan. (7487227)
1995
50
Multicentre clinical trials of benzimidazole-carbamates in human cystic echinococcosis (phase 2). (2692867)
1989

Variations for Cystic Echinococcosis

About this section

Expression for genes affiliated with Cystic Echinococcosis

About this section
Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

About this section

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL10, IL6
29.6IL10, IL6
3
Show member pathways
9.2IL10, IL17A, IL6
49.2HLA-DRB1, IL10, IL6
59.0IL10, IL6, TLR2
6
Show member pathways
9.0IL17A, IL6, TLR2
7
Show member pathways
9.0IL17A, IL6, TLR2
8
Show member pathways
8.8CD40LG, IL10, IL17A, IL6
98.8CD40LG, IL10, IL17A, IL6
10
Show member pathways
8.6CD40LG, HLA-DRB1, IL10, TLR2
11
Show member pathways
8.6IL10, IL17A, IL6, TLR2
128.6HLA-DRB1, IL10, IL6, TLR2
138.5HLA-DRB1, IL17A, IL6, TLR2
148.5CD40LG, IL10, IL6, TLR2
158.5CD40LG, IL10, IL6, TLR2
16
Show member pathways
7.7CD40LG, HLA-DRB1, IL10, IL17A, IL6, TLR2

GO Terms for genes affiliated with Cystic Echinococcosis

About this section

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CD40LG, IL17A, IL6

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:004210010.1CD40LG, IL10
2defense response to protozoanGO:004283210.1IL10, IL6
3cellular response to hepatocyte growth factor stimulusGO:003572910.1IL10, IL6
4positive regulation of chemokine productionGO:00327229.9IL6, TLR2
5positive regulation of interleukin-12 productionGO:00327359.9CD40LG, TLR2
6positive regulation of interleukin-10 productionGO:00327339.9CD40LG, TLR2
7cellular response to estradiol stimulusGO:00713929.9IL10, IL6
8response to electrical stimulusGO:00516029.8IL6, MT-CO1
9positive regulation of JAK-STAT cascadeGO:00464279.7IL10, IL6
10response to insulinGO:00328689.5IL10, IL6, TLR2
11response to lipopolysaccharideGO:00324969.2IL10, IL6, TLR2
12positive regulation of NF-kappaB transcription factor activityGO:00510929.1CD40LG, IL6, TLR2
13agingGO:00075689.0IL10, IL6, MT-ATP6, MT-CO1
14inflammatory responseGO:00069548.2CD40LG, IL10, IL17A, IL6, TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.8CD40LG, IL10, IL17A, IL6

Sources for Cystic Echinococcosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet