MCID: CYS008
MIFTS: 57

Cystic Echinococcosis malady

Infectious diseases, Respiratory diseases, Liver diseases categories

Summaries for Cystic Echinococcosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An echinococcosis that is caused by the larvae of echinococcus granulosus. hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. pulmonary involvement can produce chest pain, cough, and hemoptysis. rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. brain, bone, heart can also be infected.

MalaCards: Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to echinococcosis and hepatitis. An important gene associated with Cystic Echinococcosis is MT-ATP6 (mitochondrially encoded ATP synthase 6), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds pentoxifylline and solium have been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and lung, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Cystic Echinococcosis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases, Liver diseases


Aliases & Descriptions:

cystic echinococcosis 8
echinococcus granulosus infection 8 60
echinococcus granulosus infectious disease of thyroid 8
echinococcus granulosus infectious disease of liver 8
echinococcus granulosus infection, unspecified 8
echinococcus granulosus infection of thyroid 8
echinococcus granulosus infectious disease 8
echinococcus granulosus infection of lung 8
unspecified echinococcus granulosus 8
thyroid echinococcus granulosus 8
liver echinococcus granulosus 8
lung echinococcus granulosus 8
unilocular hydatid disease 8
unilocular echinococcosis 8


External Ids:

Disease Ontology8 DOID:1495
ICD9CM27 122.4
SNOMED-CT56 75006000, 187138004

Related Diseases for Cystic Echinococcosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to cystic echinococcosis

Clinical Features for Cystic Echinococcosis

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Drugs & Therapeutics for Cystic Echinococcosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cystic Echinococcosis

Drug clinical trials:

Search ClinicalTrials for Cystic Echinococcosis

Search NIH Clinical Center for Cystic Echinococcosis

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Genetic Tests for Cystic Echinococcosis

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Anatomical Context for Cystic Echinococcosis

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32MalaCards
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MalaCards organs/tissues related to Cystic Echinococcosis:

32
Thyroid, Liver, Lung, Heart, Bone, Brain, Testes, Spleen, Skin, T cells, Tongue

Animal Models for Cystic Echinococcosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystic Echinococcosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1IL12B, IL10, IL2RA, PRDX4, MT-CO1, HLA-B
2MP:00053877.4IGHE, TAP1, IL12B, IL10, IL2RA, TLR4
3MP:00053977.4TLR2, HLA-DQB1, HLA-B, IGHE, IL2RA, IL10

Publications for Cystic Echinococcosis

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50PubMed
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Articles related to Cystic Echinococcosis:

(show top 50)    (show all 407)
idTitleAuthorsYear
1
Ultrasound-guided treatment of cystic echinococcosis in the spleen. (23696059)
2013
2
Using specific synthetic peptide (p176) derived AgB 8/1-kDa accompanied by modified patient's sera: a novel hypothesis to follow-up of Cystic echinococcosis after surgery. (23890801)
2013
3
Cystic echinococcosis in a single tertiary care center in Rome, Italy. (24151631)
2013
4
Echinococcus granulosus genotype G1 dominated in cattle and sheep during 2003-2006 in Buenos Aires province, an endemic area for cystic echinococcosis in Argentina. (23632259)
2013
5
Differential diagnosis of cystic and alveolar echinococcosis using an immunochromatographic test based on the detection of specific antibodies. (23949310)
2013
6
Cystic echinococcosis in slaughtered cattle in Sardinia: a retrospective epidemiological study and spatial analysis. (22639130)
2012
7
The monetary burden of cystic echinococcosis in Iran. (23209857)
2012
8
Early diagnosis, treatment and follow-up of cystic echinococcosis in remote rural areas in Patagonia: impact of ultrasound training of non-specialists. (22253935)
2012
9
Vaccination of bovines against Echinococcus granulosus (cystic echinococcosis). (22406459)
2012
10
Diagnosing and staging of cystic echinococcosis: how do CT and MRI perform in comparison to ultrasound? (23145199)
2012
11
TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL-10. (21923667)
2011
12
A serological survey of cystic echinococcosis in equids in East of Turkey. (22347313)
2011
13
Performance of antigen B isolated from different hosts and cyst locations in diagnosis of cystic echinococcosis. (22347269)
2011
14
Comparative analysis of the diagnostic performance of crude sheep hydatid cyst fluid, purified antigen B and its subunit (12 Kda), assessed by ELISA, in the diagnosis of human cystic echinococcosis. (20922427)
2011
15
Sonographical and serological survey of human cystic echinococcosis and analysis of risk factors associated with seroconversion in rural communities of Kerman, Iran. (21824361)
2011
16
Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis. (19836341)
2010
17
Cystic echinococcosis due to Echinococcus equinus in a horse from southern Germany. (20453228)
2010
18
Chemoprophylactic activity of flubendazole in cystic echinococcosis. (20948209)
2010
19
Spleen cystic echinococcosis: clinical manifestations and treatment. (20095883)
2010
20
Cystic echinococcosis in children - the seventeen-year experience of two large medical centers in Serbia. (20206293)
2010
21
Cystic echinococcosis in Turkey: genetic variability and first record of the pig strain (G7) in the country. (19234876)
2009
22
Diagnosis of cystic echinococcosis, central Peruvian Highlands. (18258119)
2008
23
Albendazole treatment in cystic echinococcosis: pharmacokinetics and clinical efficacy of two different aqueous formulations. (18465143)
2008
24
Clinical management of cystic echinococcosis: state of the art, problems, and perspectives. (18784219)
2008
25
Serological evidence for human cystic echinococcosis in Slovenia. (18471283)
2008
26
Heterogeneous distribution of human cystic echinococcosis after a long-term control program in NeuquAcn, Patagonia Argentina. (17317277)
2007
27
Ultrasonographic screening for cystic echinococcosis in sheep in Tunisia. (16973283)
2007
28
The role of calcification for staging cystic echinococcosis (CE). (17473925)
2007
29
Present situation of cystic echinococcosis in Central Asia. (16361112)
2006
30
Community surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China. (17128341)
2006
31
Cystic echinococcosis: analysis of the serological profile related to the risk factors in individuals without ultrasound liver changes living in an endemic area of TacuarembA^, Uruguay. (15830820)
2005
32
Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico. (15533292)
2004
33
Cystic echinococcosis in Sardinia: the current role of sheep. (16044699)
2004
34
Immunobiology of cystic echinococcosis. (16044694)
2004
35
Human cystic echinococcosis: evaluation of post-treatment serologic follow-up by IgG subclass antibody detection. (15031526)
2004
36
Characterization of excretory-secretory products from protoscoleces of Echinococcus granulosus and evaluation of their potential for immunodiagnosis of human cystic echinococcosis. (15471012)
2004
37
Cystic echinococcosis in Algeria: cattle act as reservoirs of a sheep strain and may contribute to human contamination. (14519325)
2003
38
Combined eco-epidemiological and molecular biology approaches to assess Echinococcus granulosus transmission to humans in Mauritania: occurrence of the 'camel' strain and human cystic echinococcosis. (12497974)
2002
39
Human cystic echinococcosis in the West Bank of Palestine: surgical incidence and seroepidemiological study. (11936497)
2002
40
Cystic echinococcosis of the tongue leading to diagnosis of multiple localizations. (11693880)
2001
41
Comparison of the dot immunobinding assay and two enzyme-linked immunosorbent assay kits for the diagnosis of liver cystic echinococcosis. (11470625)
2001
42
Diagnosis of cystic echinococcosis: ultrasound imaging or countercurrent immunoelectrophoresis? (15332731)
2001
43
Differential serodiagnosis for cystic and alveolar echinococcosis using fractions of Echinococcus granulosus cyst fluid (antigen B) and E. multilocularis protoscolex (EM18). (10072134)
1999
44
An extensive ultrasound and serologic study to investigate the prevalence of human cystic echinococcosis in northern Libya. (10466978)
1999
45
Principles of the surgical approach in human liver cystic echinococcosis. (9095292)
1997
46
Musculoskeletal involvement in cystic echinococcosis: report of eight cases and review of the literature. (9168719)
1997
47
Detection, screening and community epidemiology of taeniid cestode zoonoses: cystic echinococcosis, alveolar echinococcosis and neurocysticercosis. (8701796)
1996
48
Initial observation on albendazole in combination with cimetidine for the treatment of human cystic echinococcosis. (8192515)
1994
49
Three- to 7-year follow-up after albendazole treatment of 68 patients with cystic echinococcosis (hydatid disease). (7944675)
1994
50
An international study on the serological differential diagnosis of human cystic and alveolar echinococcosis. (3488132)
1986

Genetic Variations for Cystic Echinococcosis

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Expression for genes affiliated with Cystic Echinococcosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for genes affiliated with Cystic Echinococcosis

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29KEGG, 53Reactome, 12EMD Millipore, 51QIAGEN, 59Tocris Bioscience, 37NCBI BioSystems Database, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TLR2, TLR4
29.9TLR4, TLR2
3
Hide members
9.9HLA-B, TAP1, TAP2
49.9TAP2, TAP1, HLA-B
59.7TLR4, TLR2, IL12B
69.7IL12B, TLR2, TLR4
7
Hide members
9.7IL2RA, TLR2, TLR4
8
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9.7HLA-DRB1, IL2RA, IL12B
99.7TLR4, IL10, IL12B
109.6HLA-DRB1, IL10, IL12B
119.5HLA-DQB1, HLA-DRB1, IL10
129.5TAP2, TAP1, IL10, IL2RA
139.4IL2RA, HLA-DRB1, HLA-B, HLA-DQB1
14
Hide members
9.4HLA-DQB1, HLA-B, HLA-DRB1, IL2RA
15
Hide members
9.4TLR4, TLR2, IL10, IL12B
16
Hide members
9.4TLR4, TLR2, IL10, IL12B
179.4IL12B, IL10, TLR2, TLR4
189.4IL12B, IL2RA, HLA-DRB1, HLA-DQB1
199.3IL10, HLA-DRB1, HLA-B, HLA-DQB1
20
Hide members
9.1IL12B, IL10, IL2RA, TLR2, TLR4
21
Hide members
9.0IL2RA, HLA-DRB1, HLA-DQB1, TLR2, TLR4
22
Hide members
8.8HLA-DQB1, HLA-B, HLA-DRB1, IL2RA, IL10, IL12B
23
Hide members
8.8TLR4, TLR2, HLA-DQB1, HLA-DRB1, IL10, IL12B
248.8TLR4, TLR2, HLA-DQB1, HLA-DRB1, IL10, IL12B
258.7TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, TAP1
26
Hide members
7.9TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, IGHE
27
Hide members
7.8EEF1D, TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1

Compounds for genes affiliated with Cystic Echinococcosis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.5IL12B
2solium4410.4MT-CO1, MT-ATP6, HLA-B
3tacrolimus44 49 1112.3TLR2, IL2RA
4cycloheximide4410.3TLR2
5arabinogalactan4410.3TLR2, TLR4
6diaminopimelic acid4410.3TLR2, TLR4
7pam2csk45910.3TLR4, TLR2
8pam3csk45910.3TLR4, TLR2
9poly(i:c)5910.2TLR4, TLR2
10loxoribine44 2811.2TLR4, TLR2
11p 2774410.2IL10, TLR2
12aspartate4410.2IGHE, HLA-B
13resiquimod44 5911.1TLR2, TLR4
14glycolipid4410.1TLR4, TLR2, HLA-B
15phycoerythrin4410.1HLA-B, IL2RA
16poly(i-c)4410.1IL12B, TLR2, TLR4
17bifidobacterium4410.1IL10, TLR2
18muramyl dipeptide44 2811.1TLR4, TLR2
195 aminosalicylic acid4410.0IL2RA, IL10, IL12B
20pneumococcal4410.0HLA-B, TLR4
21glucuronoxylomannan4410.0IL10, TLR2, TLR4
22polymyxin b4410.0TLR4, TLR2, IL10
23cyclosporin a44 28 5911.9HLA-B, IGHE, IL2RA
242,5-oligoadenylate449.9TLR4, HLA-B, IL2RA, IL10
25ccl344 2810.8TLR4, TLR2, IL10
26ifn-alpha449.8TAP1, IL10, IL2RA, TLR4
27imiquimod44 28 59 1112.8TLR4, TLR2, IL10, IL12B
28heroin44 49 1111.8IGHE, IL10, CES2
29peptidoglycan44 2810.8TLR4, TLR2, IL10, IL12B
30dexamethasone44 49 28 1112.8TLR4, TLR2, IGHE
31montelukast44 49 28 1112.7IGHE, IL2RA, IL10
32h2o2449.7IL2RA, PRDX4
33rantes449.7TLR4, TLR2, HLA-B, IL2RA, IL12B
34calcitriol44 59 11 2412.7IL10, IL2RA, TLR2, TLR4
35lipoteichoic acid449.6IL12B, IL10, HLA-B, TLR2, TLR4
36polyinosinic-polycytidylic acid449.6TLR4, TLR2, HLA-B, IL10, IL12B
37latex449.6IGHE, HLA-B, TLR2, TLR4
38ivig449.6IL10, IL2RA, IGHE
39il 10449.6TLR4, TLR2, IL2RA, IL10, IL12B
40infliximab44 49 1111.5TLR4, IGHE, IL2RA, IL10
41chloroquine44 2 49 28 1113.5IL10, IL2RA, TLR4
42allergens449.4IL10, IGHE, HLA-DRB1, TLR4
43sb 20358044 5910.4TLR4, TLR2, IL10, IL12B
44polysaccharide449.4IL2RA, IGHE, HLA-B, TLR2, TLR4
45glutamine449.3TLR2, HLA-DQB1, IGHE, TAP1, TAP2
46methotrexate44 49 1111.3HLA-DRB1, IGHE, IL2RA, IL10
47histamine44 28 2411.2TLR4, TLR2, IGHE, IL2RA, IL10
48vitamin d449.0TLR4, TLR2, IGHE, IL2RA, IL10, IL12B
49atp44 289.9TLR4, TLR2, HLA-B, HLA-DRB1, MT-ATP6, MT-CO1
50alanine448.9TLR4, TLR2, HLA-DRB1, IGHE, TAP1, TAP2

GO Terms for genes affiliated with Cystic Echinococcosis

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16Gene Ontology
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Cellular components related to Cystic Echinococcosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.0TAP1, TAP2
2integral to lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-B, HLA-DQB1
3ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-B, HLA-DQB1
4eukaryotic translation elongation factor 1 complexGO:0058539.5EEF1D, EEF1B2
5external side of plasma membraneGO:0098979.4IL2RA, HLA-DRB1, TLR2, TLR4

Biological processes related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.4TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.4TAP2, TAP1
3peptide transportGO:01583310.4TAP1, TAP2
4antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.3TAP1, TAP2
5positive regulation of macrophage cytokine productionGO:06090710.2TLR4, TLR2
6cellular response to lipoteichoic acidGO:07122310.2TLR4, TLR2
7I-kappaB phosphorylationGO:00725210.1TLR4, TLR2, PRDX4
8immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.1HLA-DQB1, HLA-DRB1
9positive regulation of MHC class II biosynthetic processGO:04534810.1TLR4, IL10
10negative regulation of interleukin-17 productionGO:03270010.1IL12B, TLR2, TLR4
11positive regulation of NF-kappaB import into nucleusGO:04234610.1IL12B, TLR2, TLR4
12positive regulation of interleukin-12 productionGO:03273510.1IL12B, TLR2, TLR4
13T-helper 1 type immune responseGO:04208810.1IL12B, HLA-DRB1, TLR4
14positive regulation of T cell mediated cytotoxicityGO:00191610.0TAP2, TAP1, IL12B, HLA-B
15positive regulation of tumor necrosis factor productionGO:03276010.0IL12B, TLR2, TLR4
16positive regulation of inflammatory responseGO:05072910.0TLR4, TLR2, IL12B
17humoral immune response mediated by circulating immunoglobulinGO:00245510.0HLA-DRB1, HLA-DQB1
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.0HLA-B, TAP1, TAP2
19positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, TLR2
20negative regulation of growth of symbiont in hostGO:04413010.0TLR2, IL10, IL12B
21antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.0TAP2, TAP1, HLA-B
22positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR2, TLR4
23negative regulation of interferon-gamma productionGO:0326899.9TLR4, HLA-DRB1, IL10
24interferon-gamma-mediated signaling pathwayGO:0603339.9HLA-DRB1, HLA-B, HLA-DQB1
25inflammatory response to antigenic stimulusGO:0024379.9IL2RA, HLA-DRB1
26negative regulation of T cell proliferationGO:0421309.9HLA-DRB1, IL2RA, IL10
27cellular response to lipopolysaccharideGO:0712229.9TLR4, IL10, IL12B
28negative regulation of interleukin-12 productionGO:0326959.7IL10, TLR2
29antigen processing and presentation of peptide antigen via MHC class IGO:0024749.6HLA-B, TAP1, TAP2
30immune responseGO:0069558.7TLR4, TLR2, HLA-DQB1, HLA-B, HLA-DRB1, IGHE

Molecular functions related to Cystic Echinococcosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tapasin bindingGO:04698010.2TAP1, TAP2
2peptide transporter activityGO:01519710.2TAP1, TAP2
3TAP2 bindingGO:04697910.2TAP1, TAP2
4TAP1 bindingGO:04697810.1TAP1, TAP2
5oligopeptide-transporting ATPase activityGO:01542110.1TAP1, TAP2
6MHC class I protein bindingGO:04228810.1TAP2, TAP1
7lipopolysaccharide receptor activityGO:0018759.8TLR2, TLR4
8peptide antigen bindingGO:0426059.8TAP2, TAP1, HLA-DRB1, HLA-B
9MHC class II receptor activityGO:0323959.6HLA-DRB1, HLA-DQB1

Products for genes affiliated with Cystic Echinococcosis

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Sources for Cystic Echinococcosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet