MCID: CYS008
MIFTS: 46

Cystic Echinococcosis malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Gastrointestinal diseases, Respiratory diseases, Liver diseases

Aliases & Classifications for Cystic Echinococcosis

Aliases & Descriptions for Cystic Echinococcosis:

Name: Cystic Echinococcosis 12 56 14
Echinococcus Granulosus Infection 12 69
Echinococcus Granulosus Infectious Disease of Thyroid 12
Echinococcus Granulosus Infectious Disease of Liver 12
Echinococcus Granulosus Infection, Unspecified 12
Echinococcus Granulosus Infection of Thyroid 12
Echinococcus Granulosus Infectious Disease 12
Echinococcus Granulosus Infection of Lung 12
Unspecified Echinococcus Granulosus 12
Thyroid Echinococcus Granulosus 12
Liver Echinococcus Granulosus 12
Lung Echinococcus Granulosus 12
Unilocular Hydatid Disease 12
Unilocular Echinococcosis 12
Hydatid Disease 56
Echinococcosis 69
Hydatidosis 56

Characteristics:

Orphanet epidemiological data:

56
cystic echinococcosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1495
ICD9CM 35 122.4
SNOMED-CT 64 187138004 75006000
Orphanet 56 ORPHA400
MESH via Orphanet 43 D004443
UMLS via Orphanet 70 C0013502
UMLS 69 C0152068

Summaries for Cystic Echinococcosis

Disease Ontology : 12 An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

MalaCards based summary : Cystic Echinococcosis, also known as echinococcus granulosus infection, is related to hepatitis and echinococcosis. An important gene associated with Cystic Echinococcosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and lung, and related phenotype is endocrine/exocrine gland.

Related Diseases for Cystic Echinococcosis

Diseases related to Cystic Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.6 HLA-DRB1 IL10 IL6
2 echinococcosis 11.7
3 tungiasis 10.2 IL10 MT-ATP6
4 cervical adenoid basal carcinoma 10.2 HLA-DRB1 IL10
5 maturity-onset diabetes of the young 10.2 CD40LG IL10
6 oculoauricular syndrome 10.2 CD40LG MT-CO1
7 neonatal antiphospholipid syndrome 10.2 HLA-DRB1 IL17A
8 diabetic angiopathy 10.2 CD40LG IL10
9 intracranial abscess 10.2 CES1 MT-CO1
10 facial paralysis 10.2 CD40LG IL10
11 dermatitis herpetiformis 10.2 CD40LG IL17A
12 myofibroma 10.2 HLA-DRB1 IL10
13 odontogenic myxoma 10.2 CD40LG IL17A
14 swine influenza 10.2 HLA-DRB1 IL6
15 thrombophlebitis migrans 10.2 CD40LG MT-CO1
16 centronuclear myopathy 5 10.2 CD40LG IL10
17 parkinson disease 11 10.1 IL10 IL17A
18 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.1 HLA-DRB1 IL6
19 ureter inverted papilloma 10.1 IL10 IL6
20 neonatal hypoxic and ischemic brain injury 10.1 IL10 IL6
21 spotted fever 10.1 CD40LG TLR2
22 childhood electroclinical syndrome 10.1 IL10 IL6
23 transient tic disorder 10.1 IL10 IL6
24 aseptic meningitis 10.1 HLA-DRB1 MT-CO1 TLR2
25 hypertensive heart disease 10.1 CD40LG TLR2
26 heart conduction disease 10.1 CD40LG HLA-DRB1 IL10
27 dysplastic nevus syndrome 10.1 CD40LG IL17A
28 nystagmus, congenital motor, autosomal recessive 10.1 HLA-DRB1 TLR2
29 clostridium difficile colitis 10.1 HLA-DRB1 IL6
30 respiratory system disease 10.1 CD40LG HLA-DRB1 IL10
31 generalized atherosclerosis 10.1 CD40LG IL6
32 inner ear disease 10.1 CD40LG IL6
33 peripheral artery disease 10.1 HLA-DRB1 IL10 TLR2
34 gastric lymphoma 10.1 IL17A IL6
35 angiostrongyliasis 10.1 MT-CO1 MT-ND1
36 periarthritis 10.1 HLA-DRB1 IL10 TLR2
37 erythematosquamous dermatosis 10.1 HLA-DRB1 IL10 TLR2
38 motor peripheral neuropathy 10.1 CD40LG IL10 IL17A
39 xanthogranulomatous cholecystitis 10.1 CD40LG IL10 IL17A
40 endogenous depression 10.1 CD40LG HLA-DRB1 TLR2
41 chorioretinitis 10.1 CD40LG HLA-DRB1 IL10
42 nguyen syndrome 10.1 IL10 IL17A TLR2
43 familial acute necrotizing encephalopathy 10.1 HLA-DRB1 IL10
44 complex regional pain syndrome 10.1 CD40LG IL10 IL17A
45 central sleep apnea 10.0 CD40LG IL17A
46 aortic coarctation 10.0 IL6 TLR2
47 niemann-pick disease 10.0 HLA-DRB1 IL17A IL6
48 congenital hypothyroidism 10.0 CD40LG IL10 TLR2
49 rickettsialpox 10.0 CD40LG IL10 TLR2
50 lepromatous leprosy 10.0 IL10 IL6

Graphical network of the top 20 diseases related to Cystic Echinococcosis:



Diseases related to Cystic Echinococcosis

Symptoms & Phenotypes for Cystic Echinococcosis

MGI Mouse Phenotypes related to Cystic Echinococcosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CD40LG CES1 IL10 IL17A IL6 TLR2

Drugs & Therapeutics for Cystic Echinococcosis

Drugs for Cystic Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


id Name Status NCT ID Phase
1 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018
2 Epi Cystic Hydatid Disease Peru Completed NCT00138346

Search NIH Clinical Center for Cystic Echinococcosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Cystic Echinococcosis

Anatomical Context for Cystic Echinococcosis

MalaCards organs/tissues related to Cystic Echinococcosis:

39
Thyroid, Liver, Lung, Heart, Bone, Brain, Testes

Publications for Cystic Echinococcosis

Articles related to Cystic Echinococcosis:

(show top 50) (show all 487)
id Title Authors Year
1
In vivo evaluation of the efficacy of combined albedazole-IFN-I+ treatment for cystic echinococcosis in mice. ( 27928681 )
2017
2
Expert Reliability for the World Health Organization Standardized Ultrasound Classification of Cystic Echinococcosis. ( 28070008 )
2017
3
Proteomic investigation of human cystic echinococcosis in the liver. ( 27986452 )
2017
4
Cystic Echinococcosis: One Entity, Two Unusual Locations. ( 27222337 )
2016
5
Cystic echinococcosis in Southern Israel. ( 26751890 )
2016
6
Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. ( 27085708 )
2016
7
ZOONOTIC ENCOUNTERS AT THE SLAUGHTERHOUSE: PATHWAYS AND POSSIBILITIES FOR THE CONTROL OF CYSTIC ECHINOCOCCOSIS IN NORTHERN MOROCCO. ( 27428068 )
2016
8
Diagnosis of cystic echinococcosis in buffaloes by native 8A kDa antigen using latex agglutination test (LAT). ( 27876957 )
2016
9
Diagnostic Accuracy of Antigen 5-Based ELISAs for Human Cystic Echinococcosis. ( 27023205 )
2016
10
A study of morphological aspects of cystic echinococcosis in sheep in Sardinia. ( 27060775 )
2016
11
Gene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis. ( 27467147 )
2016
12
Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice. ( 27605805 )
2016
13
Percutaneous Treatment of Splenic Cystic Echinococcosis: Results of 12 Cases. ( 26676108 )
2016
14
Natural and induced antibodies contribute to differential susceptibility to secondary cystic echinococcosis of Balb/c and C57Bl/6 mice. ( 26238549 )
2016
15
Retrospective study of human cystic echinococcosis over the past decade in France, using a nationwide hospital medical information database. ( 27473835 )
2016
16
Cystic echinococcosis: Future perspectives of molecular epidemiology. ( 27237060 )
2016
17
Erratum to: First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". ( 27846866 )
2016
18
Control programme for cystic echinococcosis in Uruguay. ( 27223652 )
2016
19
Sero-epidemiological value of some hydatid cyst antigen in diagnosis of human cystic echinococcosis. ( 27065597 )
2016
20
Cutaneous Disease as the First Manifestation of Cystic Echinococcosis. ( 27489329 )
2016
21
The Economic Impact of Cystic Echinococcosis in Rio Negro Province, Argentina. ( 26787144 )
2016
22
Comparative Evaluation of Liposomal Albendazole and Tablet-Albendazole Against Hepatic Cystic Echinococcosis: A Non-Randomized Clinical Trial. ( 26825878 )
2016
23
Costs Associated with Surgically Treated Cases of Abdominal Cystic Echinococcosis: A Single Center's Experience from 2008 to 2014, Pavia, Italy. ( 27273641 )
2016
24
Development and evaluation of real-time loop-mediated isothermal amplification assay for rapid detection of cystic echinococcosis. ( 27619674 )
2016
25
Watch and Wait Management of Inactive Cystic Echinococcosis - Does the Path to Inactivity Matter - Analysis of a Prospective Patient Cohort. ( 27992434 )
2016
26
Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis. ( 27820824 )
2016
27
Correlation of serum sHLA-G levels with cyst stage in patients with cystic echinococcosis: is it an immune-evasion strategy? ( 27120498 )
2016
28
Antibody profiling in ultrasound normal individuals with positive serology for cystic echinococcosis. ( 26729409 )
2016
29
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression. ( 27177776 )
2016
30
Investigation of the use of serology and ultrasonography to detect hepatic cystic echinococcosis in Heilongjiang, China, using a Bayesian framework. ( 27412377 )
2016
31
The first meeting of the European Register of Cystic Echinococcosis (ERCE). ( 27126135 )
2016
32
Cystic echinococcosis is an occupational disease? ( 27605752 )
2016
33
Bayesian spatial analysis of the surgical incidence rate of human cystic echinococcosis in north-eastern Iran. ( 27496620 )
2016
34
The intermediate host immune response in cystic echinococcosis. ( 26683283 )
2016
35
Diagnostic value of semi-purified antigens of hydatid cyst fluid in human cystic echinococcosis. ( 26751885 )
2016
36
Cystic Echinococcosis. ( 26677245 )
2016
37
Cystic Echinococcosis Epidemiology in Spain Based on Hospitalization Records, 1997-2012. ( 27547975 )
2016
38
Abdominal Cystic Echinococcosis Treated with Albendazole. A Pediatric Cohort Study. ( 27589236 )
2016
39
The Seroprevalence of Human Cystic Echinococcosis in Iran: A Systematic Review and Meta-Analysis Study. ( 27830083 )
2016
40
Role of soluble programmed death-1 (sPD-1) and sPD-ligand 1 in patients with cystic echinococcosis. ( 26889250 )
2016
41
A Study of Cross-Reactivity between Recombinant EPC1 Antigen of Echinococcus granulosus in Serum from Patients with Confirmed Cystic Echinococcosis Infection and Other Parasitic Infections. ( 27091868 )
2016
42
Treatment of Hepatic Cystic Echinococcosis in Patients from the Southeastern Rhodope Region of Bulgaria in 2004-2013: Comparison of Current Practices with Expert Recommendations. ( 26834196 )
2016
43
First meeting "Cystic echinococcosis in Chile, update in alternatives for control and diagnostics in animals and humans". ( 27624561 )
2016
44
Comparison of the Diagnostic Accuracy of Three Rapid Tests for the Serodiagnosis of Hepatic Cystic Echinococcosis in Humans. ( 26871432 )
2016
45
Slaughterhouse survey of cystic echinococcosis in cattle and sheep from the Republic of Moldova. ( 25727141 )
2015
46
eComment. Evidence-based diagnosis and treatment of intraaortic cystic echinococcosis. ( 26392585 )
2015
47
Knowledge, attitude, and practices (KAP) and risk factors analysis related to cystic echinococcosis among residents in Tibetan communities, Xiahe County, Gansu Province, China. ( 25757370 )
2015
48
A rare presentation of cystic echinococcosis: aortic involvement. ( 26180090 )
2015
49
Evaluation of a New Immunochromatographic Test Using Recombinant Antigen B8/1 for Diagnosis of Cystic Echinococcosis. ( 26447116 )
2015
50
Alveolar and cystic echinococcosis in Europe: Old burdens and new challenges. ( 26299934 )
2015

Variations for Cystic Echinococcosis

Expression for Cystic Echinococcosis

Search GEO for disease gene expression data for Cystic Echinococcosis.

Pathways for Cystic Echinococcosis

Pathways related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CD40LG HLA-DRB1 IL10 IL17A IL6
2
Show member pathways
12.62 CD40LG HLA-DRB1 IL10 IL17A IL6
3 12.31 CD40LG IL10 IL17A TLR2
4
Show member pathways
12.26 HLA-DRB1 IL10 IL17A IL6 TLR2
5
Show member pathways
12.21 CD40LG IL10 IL17A IL6
6
Show member pathways
12.08 IL17A IL6 TLR2
7
Show member pathways
12.03 CD40LG HLA-DRB1 IL10 TLR2
8 11.96 HLA-DRB1 IL10 IL6 TLR2
9
Show member pathways
11.94 IL10 IL17A IL6
10 11.78 IL10 IL17A IL6
11
Show member pathways
11.72 IL17A IL6 TLR2
12 11.68 IL10 IL6 TLR2
13
Show member pathways
11.59 IL10 IL17A IL6 TLR2
14 11.41 HLA-DRB1 IL17A IL6 TLR2
15 11.14 IL10 IL6
16 11.13 IL10 IL6
17 11.1 CD40LG IL10 IL6 TLR2
18 11.07 IL17A IL6
19 11.02 HLA-DRB1 IL10 IL6
20 10.96 CD40LG IL10 IL17A IL6
21 10.61 CD40LG IL10 IL6 TLR2

GO Terms for Cystic Echinococcosis

Cellular components related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD40LG HLA-DRB1 IL17A IL6

Biological processes related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.71 IL10 IL6 TLR2
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 CD40LG IL6 TLR2
3 cellular response to estradiol stimulus GO:0071392 9.57 IL10 IL6
4 negative regulation of T cell proliferation GO:0042130 9.56 HLA-DRB1 IL10
5 B cell proliferation GO:0042100 9.55 CD40LG IL10
6 response to electrical stimulus GO:0051602 9.52 IL6 MT-CO1
7 negative regulation of interferon-gamma production GO:0032689 9.51 HLA-DRB1 IL10
8 positive regulation of interleukin-12 production GO:0032735 9.49 CD40LG TLR2
9 positive regulation of interleukin-10 production GO:0032733 9.48 CD40LG TLR2
10 defense response to protozoan GO:0042832 9.46 IL10 IL6
11 aging GO:0007568 9.46 IL10 IL6 MT-ATP6 MT-CO1
12 positive regulation of chemokine production GO:0032722 9.43 IL6 TLR2
13 response to insulin GO:0032868 9.43 IL10 IL6 TLR2
14 cellular response to hepatocyte growth factor stimulus GO:0035729 9.37 IL10 IL6
15 inflammatory response GO:0006954 9.35 CD40LG IL10 IL17A IL6 TLR2
16 response to molecule of bacterial origin GO:0002237 9.32 IL10 TLR2
17 immune response GO:0006955 9.1 CD40LG HLA-DRB1 IL10 IL17A IL6 TLR2

Molecular functions related to Cystic Echinococcosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL10 IL17A IL6

Sources for Cystic Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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