CF
MCID: CYS001
MIFTS: 91

Cystic Fibrosis (CF) malady

Gastrointestinal, Reproductive, Respiratory, Endocrine categories

Summaries for Cystic Fibrosis

Sources:
43NIH Rare Diseases, 34MedlinePlus, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Cystic fibrosis (cf) is an inherited disease of the mucus and sweat glands. it affects mostly your lungs, pancreas, liver, intestines, sinuses and sex organs. cf causes your mucus to be thick and sticky. the mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. this can lead to problems such as repeated lung infections and lung damage. the symptoms and severity of cf vary widely. some people have serious problems from birth. others have a milder version of the disease that doesn't show up until they are teens or young adults. although there is no cure for cf, treatments have improved greatly in recent years. until the 1980s, most deaths from cf occurred in children and teenagers. today, with improved treatments, some people who have cf are living into their forties, fifties, or older. nih: national heart, lung, and blood institute

MalaCards: Cystic Fibrosis, also known as mucoviscidosis, is related to bronchiectasis and aspergillosis, and has symptoms including autosomal recessive inheritance, hepatomegaly/liver enlargement (excluding storage disease) and repeat respiratory infections. An important gene associated with Cystic Fibrosis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) and Clathrin-dependent protein traffic. The drugs acetylcysteine and sodium phenylbutyrate and the compounds calcium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

NIH Rare Diseases:43 Cystic fibrosis (cf) is an inherited condition that causes mucus to build up and clog some of the organs in the body, particularly in the lungs and pancreas. when mucus clogs the lungs, it can make breathing very difficult. the thick mucus also causes bacteria to get stuck in the airways, which causes inflammation and infections. these infections can cause chronic coughing, and wheezing. over time, mucus buildup and infections can lead to permanent lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs. mucus can also block the digestive tract and pancreas, leading to digestive problems. cf is caused by mutations in the cftr gene and is inherited in an autosomal recessive pattern. last updated: 4/4/2013

Genetics Home Reference:21 Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs. The disorder's most common signs and symptoms include progressive damage to the respiratory system and chronic digestive system problems. The features of the disorder and their severity varies among affected individuals.

Wikipedia:64 Cystic fibrosis (CF), also known as mucoviscidosis, is an autosomal recessive genetic disorder that... more...

Description from OMIM:47 219700

Aliases & Classifications for Cystic Fibrosis

Sources:
8Disease Ontology, 9diseasecard, 64Wikipedia, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Reproductive, Respiratory, Endocrine


Characteristics (Orphanet epidemiological data):

49
cystic fibrosis:
Inheritance: Autosomal recessive; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy; Age of death: Young adult


Aliases & Descriptions:

cystic fibrosis 8 9 64 43 20 22 21 47 10 45 49 34 31 61
mucoviscidosis 8 64 43 21 49
cf 8 64 43 21 49
fibrocystic disease of the pancreas 64
fibrocystic disease of pancreas 21
cystic fibrosis of pancreas 21
chronic fatigue syndrome 61


External Ids:

Disease Ontology8 DOID:1485
MeSH35 D003550
ICD9CM27 277.0
OMIM47 219700
NCIt40 C2975
MESH via Orphanet36 D003550
ICD10 via Orphanet26 E84
SNOMED-CT via Orphanet58 190905008
UMLS via Orphanet62 C0010674

Related Diseases for Cystic Fibrosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cystic Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiectasis31.5MPO, IL8, CFTR, ELANE, MBL2
2aspergillosis31.4MBL2, ELANE
3allergic bronchopulmonary aspergillosis31.4CFTR, MBL2
4asthma31.0DNASE1, MBL2, ELANE, S100A8, IL8, MPO
5pancreatitis, chronic30.9DNASE1, CFTR, TGFB1, ELANE
6sinusitis30.7CFTR
7acute pancreatitis30.7ELANE, CFTR, IL8, MPO
8infertility30.6CFTR
9atopy30.6MPO
10primary sclerosing cholangitis30.5CFTR, ELANE, MPO
11pulmonary disease, chronic obstructive30.5TGFB1
12bronchiolitis30.5IL8
13bronchitis30.5ELANE, CFTR, IL8, S100A9, S100A8, DNASE1
14arthritis30.5S100A9, TGFB1, MPO, S100A8, IL8
15adenocarcinoma30.5S100A9, S100A8, TGFB1
16idiopathic pulmonary fibrosis30.3ELANE, IL8, TGFB1
17alcoholic pancreatitis30.3ELANE, CFTR
18cftr-related disorders30.3CFTR
19sepsis30.2ELANE, MBL2, MPO, DEFB1, S100A8, IL8
20duodenal ulcer30.2IL8, S100A8, DEFB1
21cholera30.2CFTR, DNASE1
22allergic rhinitis30.1IL8, MPO
23atherosclerosis29.9S100A9, IL8, MBL2, MPO, TGFB1, ELANE
24systemic lupus erythematosus29.9S100A8, DNASE1, MPO, MBL2, S100A9
25septic shock29.9ELANE, IL8, MBL2
26bronchopulmonary dysplasia29.9IL8, ELANE
27adenoma29.9S100A8
28arthropathy29.9S100A8, S100A9
29meconium ileus10.9
30ileus10.9
31stenotrophomonas maltophilia10.8
32pulmonary function10.7
33chronic pain10.7
34mycobacterium abscessus10.7
35exocrine pancreatic insufficiency10.6
36meconium ileus in cystic fibrosis10.6
37char syndrome10.6
38chronic orthostatic intolerance10.6
39orthostatic intolerance10.6
40myofascial pain syndrome10.5
41primary ciliary dyskinesia10.5
42pancreatitis, idiopathic10.5
43multiple chemical sensitivity10.5
44acrodermatitis10.4
45acrodermatitis enteropathica10.4
46enteropathica10.4
47postural orthostatic tachycardia syndrome10.4
48glucose intolerance10.4
49steatorrhea10.4
50portal hypertension10.4

Graphical network of the top 20 diseases related to Cystic Fibrosis:



Diseases related to cystic fibrosis

Clinical Features for Cystic Fibrosis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

219700

Symptoms:

49 (show all 9)
  • autosomal recessive inheritance
  • hepatomegaly/liver enlargement (excluding storage disease)
  • repeat respiratory infections
  • malabsorption/chronic diarrhea/steatorrhea
  • lung fibrosis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • structural anomalies of the liver and the biliary tract
  • structural anomalies of the pancreas
  • agammaglobulinemia/hypogammaglobulinemia/b-cell deficiency

Drugs & Therapeutics for Cystic Fibrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cystic Fibrosis

Drug clinical trials:

Search ClinicalTrials for Cystic Fibrosis

Search NIH Clinical Center for Cystic Fibrosis

Search CenterWatch for Cystic Fibrosis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Cystic Fibrosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Cystic Fibrosis:
Mesenchymal stem cells for cystic fibrosis
Embryonic/Adult Cultured Cells Related to Cystic Fibrosis:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 21658631, 20801416

Genetic Tests for Cystic Fibrosis

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Cystic Fibrosis:

id Genetic test Affiliating Genes
1 Cystic Fibrosis20 22

Anatomical Context for Cystic Fibrosis

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Cystic Fibrosis:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Whole blood, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Ciliary ganglion, Hypothalamus, Cardiac myocytes, Fetal liver, Fetal lung, Trachea, Bronchial epithelium, Fetal thyroid, Pancreatic islet

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Cystic Fibrosis:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesBasal Cells Potential therapeutic candidate
2 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease
3 LungSubmucosal Glands  Affected by disease

Animal Models for Cystic Fibrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cystic Fibrosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.5TGFB1, S100A9, MBL2, STX1A, MPO, ATF6
2MP:001076812.4ATF6, MPO, STX1A, S100A8, S100A9, DEFB1
3MP:000539711.8MBL2, MPO, DNASE1, IL8, CFTR, ELANE
4MP:000538711.7S100A9, MBL2, MPO, DEFB1, DNASE1, IL8

Publications for Cystic Fibrosis

Sources:
51PubMed
See all sources

Articles related to Cystic Fibrosis:

(show top 50)    (show all 3357)
idTitleAuthorsYear
1
The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep. (24090839)
2013
2
Is there evidence for correct diagnosis in cystic fibrosis registries? (24274930)
2013
3
Pilot evaluation of web enabled symptom monitoring in cystic fibrosis. (23957685)
2013
4
Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis: a Phase II randomized study. (23516961)
2013
5
Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease. (23950911)
2013
6
Immune response, diagnosis and treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis lung disease. (23278535)
2013
7
Adult-onset Still's disease in a patient with cystic fibrosis and its successful treatment with anakinra. (22513144)
2012
8
Cystic fibrosis, primary ciliary dyskinesia and non-cystic fibrosis bronchiectasis: update 2008-11. (21680564)
2012
9
Thermally unstable gating of the most common cystic fibrosis mutant channel (I9F508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops. (21965669)
2011
10
Influence of genetic variation of the I^2-adrenergic receptor on lung diffusion in patients with cystic fibrosis. (21703359)
2011
11
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. (19966789)
2010
12
Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening. (19616787)
2009
13
Engineered common cold virus helps cultured cystic fibrosis tissues clear mucus. (20076750)
2009
14
Unique mutations of the cystic fibrosis transmembrane conductance regulator gene of three cases of cystic fibrosis in Nagasaki, Japan. (19652440)
2009
15
The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. (19918082)
2009
16
Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages. (19837664)
2009
17
Atomic model of human cystic fibrosis transmembrane conductance regulator: membrane-spanning domains and coupling interfaces. (18597042)
2008
18
Potato crisps without pancreatic extracts supplements: a potential cause of the distal intestinal obstruction in cystic fibrosis. (17124589)
2007
19
Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6. (18022401)
2007
20
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. (18059279)
2007
21
Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. (17420005)
2007
22
Abnormal intracellular lipid processing contributes to fat malabsorption in cystic fibrosis patients. (16223944)
2006
23
Cystic fibrosis lung disease following infection with Pseudomonas aeruginosa in Cftr knockout mice using novel non-invasive direct pulmonary infection technique. (16004694)
2005
24
Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]. (14593914)
2003
25
Partial splenectomy in cystic fibrosis patients with hypersplenism. (12538318)
2003
26
Nonclassic cystic fibrosis: a clinical conundrum. (12772217)
2003
27
Normal function of the cystic fibrosis conductance regulator protein can be associated with homozygous (Delta)F508 mutation. (12409506)
2002
28
Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis. (12397022)
2002
29
Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis. (12149540)
2002
30
A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator. (11524016)
2001
31
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. (11830825)
2000
32
Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13. (10369249)
1999
33
Physiopathology of cystic fibrosis lung disease]. (10472642)
1999
34
Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. (9041336)
1997
35
MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. (9247472)
1997
36
Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum. (8810619)
1996
37
Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. (8617884)
1996
38
Relationship between disease severity and inflammatory markers in cystic fibrosis. (9014602)
1996
39
Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases. (8834254)
1996
40
Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels. (7544788)
1995
41
Four adult patients with the missense mutation L206W and a mild cystic fibrosis phenotype. (8522333)
1995
42
Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients. (7525450)
1994
43
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. (7519611)
1994
44
Heterogeneity in the severity of cystic fibrosis and the role of CFTR gene mutations. (7513291)
1994
45
Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. (8275769)
1994
46
Activation of the cystic fibrosis transmembrane regulator by cyclic AMP is not correlated with inhibition of endocytosis. (7522569)
1994
47
Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia. (1379244)
1992
48
Inflammatory markers in cystic fibrosis. (1887131)
1991
49
The clinical effect and the effect on the ciliary motility of oral N-acetylcysteine in patients with cystic fibrosis and primary ciliary dyskinesia. (3282911)
1988
50
Cystic fibrosis in a patient with Kartagener syndrome. (4545192)
1974

Genetic Variations for Cystic Fibrosis

Expression for genes affiliated with Cystic Fibrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystic Fibrosis

Search GEO for disease gene expression data for Cystic Fibrosis.

Pathways for genes affiliated with Cystic Fibrosis

Sources:
12EMD Millipore, 30KEGG, 54Reactome
See all sources

Pathways related to Cystic Fibrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
11.1STX1A, CFTR, SLC9A3R1, SLC9A3R2
211.1SLC9A3R2, STX1A, CFTR, SLC9A3R1
311.0CLCA4, CLCA2, CFTR
4
Cytokine production by Th17 cells in CF (Mouse model)
11.0IL8, TGFB1, CFTR
5
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
11.0CLCA2, CFTR, SLC9A3R1
6
Regulation of degradation of wt-CFTR
11.0CFTR, DNAJC5, DERL1
7
Hide members
10.8ELANE, TGFB1

Compounds for genes affiliated with Cystic Fibrosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Cystic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.9MPO, STX1A, MBL2, S100A8, S100A9, ATF6
2nitric oxide45 11 2414.2S100A9, S100A8, MBL2, STX1A, MPO, IL8
3retinoic acid45 2413.2S100A9, S100A8, MPO, DEFB1, DNASE1, CFTR
4cysteine4512.0S100A8, MBL2, STX1A, DNAJC5, IL8, CFTR
5dmso4511.9TGFB1, CFTR, DNASE1, MPO, S100A8, S100A9
6paraffin4511.9S100A8, MBL2, MPO, DNASE1, CFTR, TGFB1
7dexamethasone45 50 29 1114.7S100A8, DEFB1, DNASE1, CFTR, TGFB1
8chlorine45 2412.7MPO, CLCA4, CLCA2, CFTR, ELANE
9cytochalasin d45 6012.7DNASE1, IL8, CFTR, SLC9A3R1, TGFB1
10chloride4511.7SLC9A3R1, CFTR, CLCA2, MPO, STX1A
11vitamin d4511.7MBL2, DNASE1, CFTR, ELANE, TGFB1
12cyclosporin a45 29 6013.6DNASE1, IL8, CFTR, ELANE, TGFB1
13amiloride45 29 1113.6MPO, CFTR, SLC9A3R2, TGFB1
14serine4511.5S100A8, MPO, IL8, TGFB1
15h2o24511.5S100A9, MPO, DNASE1, CFTR
16hyaluronic acid45 2412.5TGFB1, ELANE, IL8, DNASE1
17formaldehyde45 2412.5TGFB1, CFTR, DNASE1, MPO
18fmlp4511.5S100A9, MPO, IL8, ELANE
19lactate4511.4MPO, DNASE1, IL8, ELANE, TGFB1
20monosodium urate4511.4S100A9, S100A8, IL8
21cilomilast4511.4MPO, IL8, ELANE
22ulinastatin4511.4MPO, IL8, ELANE
23pirfenidone45 6012.4S100A9, S100A8, TGFB1
24rantes4511.4TGFB1, MBL2, S100A8
25zymosan4511.4ELANE, MPO, MBL2
26iodoacetamide4511.4MPO, DNASE1, ELANE
27polymyxin b4511.4IL8, DEFB1, MBL2
28anaphylatoxin4511.3MPO, IL8, ELANE
29fluticasone propionate45 50 60 1114.3MPO, IL8, ELANE
30alginate4511.3DNASE1, ELANE, TGFB1
31cytochalasin b4511.2ELANE, MPO, S100A9
32csp-14511.2STX1A, DNAJC5
331-hydroxyphenazine4511.2MPO, ELANE
34sivelestat sodium hydrate4511.2IL8, ELANE
35methacholine45 1112.2MPO, IL8, TGFB1
36diphenyleneiodonium4511.1TGFB1, IL8, MPO
37curosurf4511.1IL8, ELANE
38endotoxin4511.1S100A8, S100A9
39dcpib6011.1CLCA2, CFTR
40cftrinh 1726011.1CLCA2, CFTR
41survanta4511.1IL8, ELANE
42sivelestat4511.1IL8, ELANE
43valine4511.1CFTR, ELANE
44n-formylmethionyl-leucylphenylalanine4511.0MPO, IL8, ELANE
45luminol4511.0MPO, S100A8
46superoxide45 2411.9ELANE, MBL2
47pge24510.9TGFB1
48rebamipide4510.8IL8, MPO
49erythromycin45 50 2 1113.5TGFB1
50pentoxifylline45 1111.5ELANE, MPO

GO Terms for genes affiliated with Cystic Fibrosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cystic Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.4TGFB1, S100A9, S100A8, MBL2, STX1A, DEFB1
2extracellular spaceGO:00561511.5TGFB1, IL8, S100A9, MBL2, S100A8, MPO
3microvillusGO:00590211.0SLC9A3R1, CFTR, TGFB1
4secretory granuleGO:03014110.9ELANE, MPO, STX1A
5apical plasma membraneGO:01632410.8SLC9A3R1, SLC9A3R2, CLCA4, CFTR

Biological processes related to Cystic Fibrosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:04274211.4DEFB1, MBL2, S100A8, S100A9
2negative regulation of growth of symbiont in hostGO:04413011.3ELANE, MPO, MBL2
3defense response to fungusGO:05083211.3S100A9, S100A8, MPO
4positive regulation of intrinsic apoptotic signaling pathwayGO:200124411.3S100A9, S100A8, SLC9A3R1
5neutrophil chemotaxisGO:03059311.2S100A9, S100A8, IL8
6inflammatory responseGO:00695411.1S100A9, S100A8, IL8, TGFB1
7endoplasmic reticulum unfolded protein responseGO:03096811.1ATF6, DERL1, IL8
8chemokine productionGO:03260211.1S100A8, S100A9
9neutrophil aggregationGO:07048811.1S100A8, S100A9
10sequestering of zinc ionGO:03211911.0S100A9, S100A8
11response to yeastGO:00187811.0MPO, ELANE
12leukocyte migration involved in inflammatory responseGO:00252311.0S100A8, S100A9
13positive regulation of NF-kappaB transcription factor activityGO:05109211.0TGFB1, S100A8, S100A9
14chronic inflammatory responseGO:00254411.0S100A8, S100A9
15negative regulation of phosphatidylinositol 3-kinase cascadeGO:01406710.9SLC9A3R2, SLC9A3R1
16acute inflammatory responseGO:00252610.7DEFB1, S100A8
17regulation of cytoskeleton organizationGO:05149310.5S100A8, S100A9

Molecular functions related to Cystic Fibrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.6S100A9, S100A8, MBL2, STX1A, ATF6, DERL1
2chloride channel activityGO:00525411.1CFTR, CLCA4, CLCA2
3protein N-terminus bindingGO:04748511.0TGFB1, DCTN4, STX1A
4Toll-like receptor 4 bindingGO:03566211.0S100A9, S100A8
5arachidonic acid bindingGO:05054410.9S100A9, S100A8
6ATP-dependent protein bindingGO:04300810.7STX1A, DNAJC5
7RAGE receptor bindingGO:05078610.5S100A8, S100A9

Products for genes affiliated with Cystic Fibrosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystic Fibrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet