Cystic Fibrosis Lung Disease malady

MalaCards: Cystic Fibrosis Lung Disease, also known as pulmonary cystic fibrosis, is related to alpha 1-antitrypsin deficiency and fibrosis. An important gene associated with Cystic Fibrosis Lung Disease is IFRD1 (interferon-related developmental regulator 1), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response. The compounds hyaluronic acid and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include lung, b cells and endothelial, and related mouse phenotypes are hematopoietic system and respiratory system.

cystic fibrosis lung disease 7 pulmonary cystic fibrosis 43

cystic fibrosis lung 32 lung cyst 43

Diseases related to cystic fibrosis lung disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 607)

id	Related Disease	Score	Top Affiliating Genes
1	alpha 1-antitrypsin deficiency	27.2	SERPINA1, BPI, CFTR, MPO, IL10, IL8
2	fibrosis	24.8	RECK, GCLC, SERPINA1, BPI, RASSF6, SCGB1A1
3	cystic fibrosis	24.8	RECK, GCLC, SERPINA1, BPI, RASSF6, SCGB1A1
4	pseudomonas stutzeri infections	13.5	CFTR, ELANE
5	congenital bilateral absence of vas deferens	13.5	CFTR, TGFB1
6	invasive aspergillosis	13.4	IL17A, MBL2, TLR1
7	gastric cardia adenocarcinoma	13.4	IL8, TGFB1, CXCR1
8	rheumatoid arthritis	13.2	IL1R1, IL1RN, MBL2
9	endocervicitis	13.2	MUC5AC, IL8, DMBT1, TGFB1
10	idiopathic interstitial pneumonia	13.2	SCGB1A1, IL8, ELANE, TGFB1
11	peyronies disease	13.2	SERPINA1, NOS2, TGFB1
12	ocular cicatricial pemphigoid	13.1	TNF, RNASE3, TGFB1
13	pulmonary eosinophilia	13.1	SERPINA1, IL8, RNASE3
14	radiculopathy	13.1	IL17A, IL1A, IL1R1
15	raynaud disease	13.1	MPO, IL1R1
16	iga glomerulonephritis	13.1	SERPINA1, SCGB1A1, IL1R1, MBL2, TGFB1
17	glanders	13.1	CFTR, MPO, ELANE, TGFB1
18	hereditary pancreatitis	13.1	SERPINA1, MUC5AC, CFTR, ELANE, TGFB1
19	allergic rhinitis	13.1	MPO, IL8, RNASE3
20	mycobacterium marinum	13.0	IL8, TNF
21	lacrimal duct obstruction	13.0	SERPINA1, MUC5AC, RNASE3, CXCR1, ADRB2
22	collagenous colitis	13.0	MPO, NOS2, RNASE3
23	pustulosis of palm and sole	13.0	TNF, ELANE
24	lung adenocarcinoma	13.0	SERPINA1, SCGB1A1, MUC5AC, TGFB1, ADRB2
25	stenotrophomonas maltophilia	13.0	BPI, IL10, IL8
26	allergic bronchopulmonary aspergillosis	12.9	CFTR, IL10, MBL2
27	common cold	12.9	MUC5B, CFTR, IL1R1, IL8, RNASE3
28	primary sclerosing cholangitis	12.9	BPI, CFTR, MPO, DMBT1, ELANE
29	hereditary hemorrhagic telangiectasia	12.9	IL8, NOS3, TGFB1
30	postural orthostatic tachycardia syndrome	12.9	NOS2, NOS3, ADRB2
31	gastritis	12.9	IL1RN, IL8, NOS2
32	cryptogenic organizing pneumonia	12.9	IL8, TNF
33	joint disorders	12.9	IL1R1, IL1RN, TNF
34	chronic sphenoidal sinusitis	12.9	MUC5AC, CFTR, IL8, RNASE3, ELANE
35	cheilitis	12.9	MPO, APEX1, TNF
36	pulpitis	12.8	IL1A, IL8, TNF
37	eosinophilic esophagitis	12.8	MUC5AC, IL10, RNASE3
38	respiratory failure	12.8	SCGB1A1, MUC5AC, CFTR, RNASE3, ELANE, ADRB2
39	endophthalmitis	12.8	IL8, TNF, ELANE
40	punctate inner choroidopathy	12.8	IL10, TNF
41	gastric cancer risk after h. pylori infection	12.8	IL1B, IL1RN
42	hypertension	12.8	NOS2, NOS3, ADRB2
43	rapidly progressive glomerulonephritis	12.8	MPO, TNF, ELANE, TGFB1
44	hemorrhagic shock and encephalopathy syndrome	12.8	MPO, NOS2, NOS3
45	alcoholic hepatitis	12.8	IL1A, IL8, TNF
46	systemic scleroderma	12.8	BPI, IL17A, IL1A, NOS3, TGFB1
47	mycobacterium abscessus	12.8	SERPINA1, TNF, TLR2
48	bacteriuria	12.8	IL8, TLR1, TLR2, TLR5, CXCR1
49	immune defect due to absence of thymus	12.8	IL10, IL1A, IL1R1
50	neisseria meningitidis infection	12.8	IL1R1, IL1RN, MBL2, TLR2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cystic fibrosis lung disease:

²²

MGI Mouse Phenotypes related to cystic fibrosis lung disease:

²⁵ (show all 15)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	CXCL6, TLR5, IL17A
2	respiratory system phenotype	MP:0005388	10.2	CFTR, SCGB1A1
3	endocrine/exocrine gland phenotype	MP:0005379	10.2	TLR2
4	skeleton phenotype	MP:0005390	9.5	IL1R1, IL17A, RECK
5	growth/size phenotype	MP:0005378	8.8	GABPA, ADRB2, TLR5, NOS3, IFRD1, APEX1
6	digestive/alimentary phenotype	MP:0005381	8.5	TGFB1, TLR2, NOS3, NOS2, DMBT1, IL17A
7	immune system phenotype	MP:0005387	7.9	MUC5AC, GABPA, ADRB2, CXCL6, ELANE, DMBT1
8	adipose tissue phenotype	MP:0005375	7.6	ADRB2, TGFB1, TLR5, TLR2, NOS3, NOS2
9	liver/biliary system phenotype	MP:0005370	6.9	TGFB1, TLR5, TLR2, NOS3, NOS2, TNF
10	muscle phenotype	MP:0005369	6.6	NOS3, TLR2, TGFB1, ADRB2, GABPA, NOS2
11	tumorigenesis	MP:0002006	6.6	TGFB1, TLR2, ELANE, NOS2, DMBT1, TNF
12	homeostasis/metabolism phenotype	MP:0005376	6.3	NOS3, ELANE, TLR2, TLR5, TGFB1, CXCL6
13	cellular phenotype	MP:0005384	5.9	ADRB2, TGFB1, TLR5, TLR2, NOS3, NOS2
14	cardiovascular system phenotype	MP:0005385	5.4	NOS2, NOS3, TLR2, TLR5, TGFB1, ADRB2
15	mortality/aging	MP:0010768	4.5	TNF, DMBT1, NOS2, NOS3, ELANE, TLR2

Articles related to cystic fibrosis lung disease:

(show all 33)

id	Title	Authors	Year	Affiliating Genes
1	Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC. (21998660)	Guo X.... Knowles M.R.	2011	MUC5AC
2	Raised interleukin-17 is immunolocalised to neutrophi ls in cystic fibrosis lung disease. (21109552)	Brodlie M.... Ward C.	2011	IL17A
3	Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease. (19060118)	Mall M.A.	2009	CFTR
4	The triterpenoid CDDO limits inflammation in preclini cal models of cystic fibrosis lung disease. (19700644)	Nichols D.P.... Davis P.B.	2009	GABPA
5	IL1B polymorphisms modulate cystic fibrosis lung disease. (19431193)	Levy H.... Weiss S.T.	2009	IL1B, IL1R1, IL1A
6	Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. (19242412)	Gu Y.... Karp C.L.	2009	CFTR, IFRD1
7	Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity. (19169360)	Taylor-Cousar J.L.... Knowles M.R.	2009	FUT3, FUT2, ABO
8	TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. (18684966)	Koller B.... Hartl D.	2008	TLR1, TLR2, TLR5
9	Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. (18490781)	Blohmke C.J.... Turvey S.E.	2008	TLR5
10	Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease. (18230779)	Collaco J.M.... Cutting G.R.	2008	CFTR
11	Modulation of cystic fibrosis lung disease by variants in interleukin-8. (18563170)	Hillian A.D.... Drumm M.L.	2008	TGFB1, IL8, CXCL6
12	Tumor necrosis factor-alpha in airway secretions from cystic fibrosis patients upregulate endothelial adhesion molecules and induce airway epithelial cell apoptosis: implications for cystic fibrosis lung disease. (19144271)	Mitola S.... De Rose V.	2008	TNF
13	Inhibition of airway proteases in cystic fibrosis lung disease. (18757703)	Griese M.... Hartl D.	2008	ELANE
14	Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. (18059279)	Hartl D.... Griese M.	2007	IL8, CXCR1
15	Anti-inflammatory cytokines in cystic fibrosis lung disease. (16807263)	Starosta V.... Griese M.	2006	SCGB1A1
16	Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. (16614352)	Wright J.M.... Boyle M.P.	2006	CFTR
17	Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. (16690975)	McKone E.F.... Kavanagh T.J.	2006	CFTR, GCLC
18	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. (15563276)	Schulz B.L.... Karlsson N.G.	2005	DMBT1, MUC5B, MUC5AC
19	Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects. (16356023)	Schmitt-GrohAc S.... Zielen S.	2005	IL8, IL10, RNASE3
20	Dornase alfa reduces air trapping in children with mild cystic fibrosis lung disease: a quantitative analysis. (16236891)	Robinson T.E.... Moss R.B.	2005	APEX1
21	Cystic fibrosis lung disease following infection with Pseudomonas aeruginosa in Cftr knockout mice using novel non-invasive direct pulmonary infection technique. (16004694)	Guilbault C.... Radzioch D.	2005	CFTR
22	Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease. (15477008)	Perez-Vilar J.... Boucher R.C.	2004	MPO
23	Alpha 1-antitrypsin deficiency alleles in cystic fibrosis lung disease. (12689922)	Frangolias D.D.... Sandford A.J.	2003	SERPINA1, CFTR
24	Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. (12475759)	Verkman A.S.... Thiagarajah J.R.	2003	CFTR
25	Modifier genes in cystic fibrosis lung disease. (12677168)	Merlo C.A.... Boyle M.P.	2003	CFTR, MBL2
26	Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. (12406848)	Grasemann H.... Ratjen F.	2003	NOS3
27	Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease. (11836800)	Garred P.... Koch C.	2002	MBL2
28	Inflammatory mediators in cystic fibrosis lung disease. (11894730)	Berger M.	2002	IL8, RECK
29	beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. (12142724)	Buscher R.... Ratjen F.	2002	ADRB2
30	Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. (12181292)	Cowley E.A.... Linsdell P.	2002	CFTR
31	Anti-neutrophil cytoplasmic antibodies (ANCA) against bactericidal/permeability-increasing protein (BPI) and cystic fibrosis lung disease. (10469063)	Mahadeva R.... Lockwood C.M.	1999	BPI
32	Cystic fibrosis lung disease: the role of nitric oxid e. (10587420)	Grasemann H.... Ratjen F.	1999	NOS2
33	Physiopathology of cystic fibrosis lung disease (10472642)	Chinet T.	1999	CFTR

Genes related to cystic fibrosis lung disease according to GeneCards:

(show all 38)

id	Symbol	Description	Score	GeneCards Section Context
1	IFRD1	interferon-related developmental regulator 1	11.1	Publications, Summaries
2	TGFB1	transforming growth factor, beta 1	11.0	Publications
3	PF4V1	platelet factor 4 variant 1	11.0	Publications
4	RASSF6	Ras association (RalGDS/AF-6) domain family member 6	11.0	Publications
5	CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	11.0	Publications
6	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
7	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications
8	GABPA	GA binding protein transcription factor, alpha subunit 60kDa	11.0	Publications
9	TLR5	toll-like receptor 5	11.0	Publications
10	FUT2	fucosyltransferase 2 (secretor status included)	11.0	Publications
11	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0	Publications
12	TLR1	toll-like receptor 1	11.0	Publications
13	ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	11.0	Publications
14	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
15	GCLC	glutamate-cysteine ligase, catalytic subunit	11.0	Publications
16	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
17	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
18	BPI	bactericidal/permeability-increasing protein	11.0	Publications
19	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
20	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0	Publications
21	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
22	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
23	IL17A	interleukin 17A	11.0	Publications
24	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
25	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
26	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
27	IL1R1	interleukin 1 receptor, type I	11.0	Publications
28	IL1A	interleukin 1, alpha	11.0	Publications
29	TLR2	toll-like receptor 2	11.0	Publications
30	MPO	myeloperoxidase	11.0	Publications
31	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
32	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
33	IL8	interleukin 8	11.0	Publications
34	ELANE	elastase, neutrophil expressed	11.0	Publications
35	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
36	IL10	interleukin 10	11.0	Publications
37	TNF	tumor necrosis factor	11.0	Publications
38	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to cystic fibrosis lung disease according to GeneDecks:

(show top 50)    (show all 72)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.6	PF4V1, CXCL6
2	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.3	TLR1, TLR5
3	Bacterial infections in CF airways41	9.9	CFTR, IL1R1, TLR1, TLR2, TLR5
4	Mucin expression in CF via TLRs, EGFR signaling pathways41	9.8	TLR5, TLR2, CFTR, MUC5B, MUC5AC
5	Cytokine production by Th17 cells in CF41	9.8	CXCL6, IL8, IL17A, CFTR
6	Mucin expression in CF via IL-6, IL-17 signaling pathways41	9.8	TLR5, TLR2, IL17A, CFTR, MUC5B, MUC5AC
7	Cytokine production by Th17 cells in CF (Mouse model)41	9.7	CXCL6, TGFB1, IL8, IL17A, CFTR
8	Molecular Mechanisms of Cancer36	9.6	IL1R1, PF4V1, TGFB1, CXCL6
9	Immune response_TLR signaling pathways41	9.5	TLR5, TLR2, TLR1, IL8
10	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.5	TGFB1, TLR5, TLR2, TLR1, IL1B, IL17A
11	Inflammasome Activation Pathways37	9.4	TLR5, TLR2, TLR1, IL1R1, IL1B
12	NO-dependent CFTR activation (normal and CF)41	9.4	CFTR, NOS2, NOS3
13	Th17 Differentiation37	9.2	TGFB1, TLR5, TLR2, TLR1, IL1R1, IL1B
14	TREM1 Pathway36	9.2	TLR5, TLR2, TLR1, IL1R1, IL1B, IL1A
15	Akt Signaling36	9.2	CXCL6, PF4V1, TNF, IL10
16	Tec Kinases Signaling36	9.2	TGFB1, TLR5, TLR2, TLR1, IL8, IL10
17	Endothelin-1 Signaling Pathway36	9.2	CXCL6, PF4V1, IL1B, IL1A, IL10
18	Immune response_Bacterial infections in normal airways41	9.2	TLR5, TLR1, NOS2, IL1R1, IL1B, CFTR
19	Th1 Differentiation37	8.8	TLR5, TLR2, TLR1, TNF, IL10
20	Glucocorticoid Receptor Signaling36	8.5	TGFB1, IL8, IL1R1, IL1B, IL1A, IL10
21	HMGB1 Pathway36	8.5	TNF, IL1R1, IL1B, IL1A
22	IL-10 Pathway36	8.5	IL10, IL1A, IL1B, TNF
23	Toll-like receptor signaling pathway20	8.5	TLR5, TLR2, TLR1, TNF, IL8, IL1B
24	TRAF Pathway36	8.4	TLR5, TLR2, TLR1, TNF, IL1R1, IL1B
25	Immune response_MIF in innate immunity response41	8.4	NOS2, TNF, IL8, IL1B
26	Immune response MIF in innate immunity response10	8.4	NOS2, TNF, IL8, IL1B
27	NF-KappaB (p50-p65) Pathway36	8.3	TGFB1, TLR5, TLR2, TLR1, TNF, IL1R1
28	NF-KappaB Family Pathway36	8.3	TGFB1, TLR5, TLR2, TLR1, TNF, IL1R1
29	Cytokine Network36	8.2	TNF, IL8, IL1B, IL1A, IL10
30	Rheumatoid arthritis20	8.1	CXCL6, TGFB1, TLR2, TNF, IL8, IL1B
31	Malaria20	8.1	TGFB1, TLR2, TNF, IL8, IL1B, IL10
32	Immune response IL-1 signaling pathway10	8.1	NOS2, TNF, IL8, IL1R1, IL1B, IL1A
33	Immune response_IL-1 signaling pathway41	8.1	NOS2, TNF, IL8, IL1R1, IL1B, IL1A
34	MIF Mediated Glucocorticoid Regulation36	8.0	CXCL6, PF4V1, TNF, IL8, IL1B, IL1A
35	MIF Regulation of Innate Immune Cells36	8.0	CXCL6, PF4V1, TNF, IL8, IL1B, IL1A
36	all-trans-Retinoic Acid Signaling in Brain36	8.0	CXCL6, PF4V1, TNF, IL8, IL1B, IL1A
37	PEDF Induced Signaling36	8.0	CXCL6, PF4V1, TNF, IL8, IL1B, IL1A
38	IL-6 Pathway36	7.9	CXCL6, PF4V1, TNF, IL8, IL1B, IL1A
39	PAK Pathway36	7.8	CXCL6, TGFB1, PF4V1, TNF, IL8, IL1B
40	Leishmaniasis20	7.7	TGFB1, TLR2, NOS2, TNF, IL1B, IL1A
41	STAT3 Pathway36	7.7	CXCL6, PF4V1, TNF, IL8, IL1R1, IL1B
42	Rho Family GTPases36	7.6	CXCL6, TGFB1, PF4V1, TNF, IL8, IL1B
43	Pertussis20	7.6	CXCL6, NOS2, TNF, IL8, IL1B, IL1A
44	Chagas disease (American trypanosomiasis)20	7.6	TGFB1, TLR2, NOS2, TNF, IL8, IL1B
45	Tuberculosis20	7.6	TGFB1, TLR2, TLR1, NOS2, TNF, IL1B
46	MAPK Family Pathway36	7.6	TGFB1, TNF, IL8, IL1R1, IL1B, IL1A
47	Antioxidant Action of Vitamin-C36	7.5	CXCL6, TGFB1, PF4V1, TNF, IL8, IL1R1
48	p38 Signaling36	7.5	CXCL6, TGFB1, PF4V1, TNF, IL8, IL1R1
49	Amoebiasis20	7.3	TGFB1, TLR2, NOS2, TNF, IL8, IL1R1
50	Cytokine-cytokine receptor interaction20	7.3	CXCR1, CXCL6, TGFB1, PF4V1, TNF, IL8

Compounds related to cystic fibrosis lung disease according to GeneDecks:

(show top 50)    (show all 223)

id	Compound	Score	Top Affiliating Genes
1	hyaluronic acid32 18	11.0	SCGB1A1, RNASE3, ELANE
2	n acetylcysteine32	9.6	IL1R1, APEX1, RNASE3, MUC5AC, GCLC, CFTR
3	endotoxin32	9.5	CXCR1, ELANE, IL1R1, SCGB1A1, BPI, RECK
4	sb 20358032 42	10.2	TNF, NOS3, IL17A, IL1R1
5	histamine32 18	10.2	ADRB2, RNASE3, IL1RN, MUC5AC, MPO, TLR2
6	pge232	9.1	TLR2, IL1RN, IL1A, IL1R1, MUC5AC, CFTR
7	polyinosinic-polycytidylic acid32	8.9	NOS2, IL8, IL10, TLR2
8	rantes32	8.9	IL17A, IL1A, IL1R1, MBL2, RNASE3, TLR2
9	h2o232	8.9	MPO, ELANE, APEX1, IL1RN, CFTR, SERPINA1
10	cysteine32	8.8	ELANE, RECK, GCLC, SERPINA1, DMBT1, BPI
11	tenidap42 32	9.3	ELANE, IL1B, TNF, IL1R1, IL1A
12	groalpha32	8.3	CXCL6, TNF, IL1A, IL17A, IL10, IL1B
13	sulfasalazine32 9 9	10.2	MPO, IL1A, IL1B, IL1R1, IL1RN, TNF
14	zymosan32	8.1	TNF, RNASE3, ELANE, IL1RN, TLR2, MPO
15	gold sodium thiomalate32	8.1	TNF, IL1RN, IL1B, IL8, IL1R1, IL1A
16	taurine chloramine32	8.0	MPO, TNF, IL8, IL1B, NOS2
17	creatinine32	7.9	BPI, MPO, IL17A, IL1A, IL1R1, IL1RN
18	estrogen32	7.9	SERPINA1, MUC5AC, CFTR, IL1RN, NOS2, SCGB1A1
19	fluticasone propionate32 42 9 9	10.8	ADRB2, ELANE, TNF, IL8, MPO, IL1B
20	pdtc32	7.7	IL8, TNF, IL1A, GCLC, NOS2, TGFB1
21	toxin-132	7.6	IL8, IL1RN, IL1B, TNF, IL10
22	oxygen32 18	8.6	GABPA, SERPINA1, SCGB1A1, MUC5AC, MPO, CXCR1
23	ns 39832 42	8.6	IL1B, TGFB1, NOS2, IL17A, IL1A, IL1RN
24	gm-csf32	7.6	IL10, IL1A, IL1B, IL8, TNF, ELANE
25	ulinastatin32	7.5	TNF, IL8, IL10, MPO, ELANE
26	diphenyleneiodonium32	7.5	IL1R1, IL1B, MPO, NOS2, IL8, TNF
27	etanercept32 9 9	9.5	IL8, IL1B, IL10, TNF, IL17A, IL1R1
28	curcumin32	7.5	GABPA, TNF, IL8, IL1B, IL1A, IL17A
29	vitamin d32	7.5	ELANE, IL1RN, CFTR, IL10, IL1A, IL1R1
30	ccl332	7.5	TNF, CXCR1, IL8, IL1R1, IL1B, IL1A
31	vegf32	7.3	RECK, MBL2, NOS3, RNASE3, TGFB1, CXCL6
32	il 1032	7.2	IL1R1, TLR2, IL1B, TNF, IL8, IL1RN
33	polymyxin b32	7.2	BPI, IL10, IL1A, IL1B, IL1RN, IL8
34	methotrexate32 34 42 9 9	11.1	MUC5AC, IL10, IL17A, IL1B, IL1R1, IL1RN
35	fmlp32	7.1	CXCR1, ELANE, TNF, IL8, IL1A, IL1RN
36	lipoteichoic acid32	6.9	MBL2, TLR5, TLR2, TLR1, IL1B, IL10
37	peptidoglycan32	6.9	MBL2, APEX1, IL8, IL1RN, IL1R1, IL1B
38	lactate32	6.9	IL1RN, ELANE, TNF, IL8, RNASE3, IL1R1
39	neopterin32	6.9	IL1RN, IL1B, IL1A, IL8, MBL2, TNF
40	hydrocortisone32 9 9	8.9	ELANE, IL8, TNF, IL1R1, IL1B, IL10
41	indomethacin32 9 9	8.8	TNF, TGFB1, NOS2, IL1RN, IL1R1, CFTR
42	pentoxifylline32 9 9	8.8	TNF, IL1RN, IL8, ELANE, IL1R1, IL1B
43	leukotriene b432 42 18	8.8	MPO, IL1A, IL1RN, CXCR1, TLR2, ELANE
44	actinomycin d32	6.5	CXCR1, BPI, CFTR, IL17A, IL1A, IL1B
45	cyclosporin a32 42	7.4	CFTR, TGFB1, ELANE, TLR2, RECK, IL10
46	retinoic acid32 42 18	8.0	BPI, MUC5AC, CFTR, IL1A, MPO, IL1B
47	superoxide32 18	6.9	TLR2, ADRB2, MPO, IL1B, IL1RN, IL8
48	dexamethasone32 42 34 9 9	9.2	RNASE3, MUC5AC, TLR2, TGFB1, CXCR1, ADRB2
49	serine32	5.0	CFTR, MPO, IL1A, IL1R1, IL1RN, IL8
50	nitric oxide32 9 18 9	7.3	ADRB2, TLR2, RNASE3, NOS3, NOS2, TNF

Cellular components related to cystic fibrosis lung disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:035354	9.7	TLR2, TLR1
2	cell surface	GO:009986	8.2	IL1A, IL1R1, TNF, ELANE, TLR2, TGFB1
3	extracellular region	GO:005576	6.8	SERPINA1, CXCL6, TGFB1, ELANE, ABO, RNASE3
4	extracellular space	GO:005615	6.1	CXCL6, TGFB1, TNF, MBL2, IL8, IL1RN

Biological processes related to cystic fibrosis lung disease according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to triacyl bacterial lipopeptide	GO:071727	10.4	TLR2, TLR1
2	detection of triacyl bacterial lipopeptide	GO:042495	10.4	TLR2, TLR1
3	protein glycosylation	GO:006486	10.2	ABO, IL17A, FUT3, FUT2
4	positive regulation of toll-like receptor signaling pathway	GO:034123	10.2	TLR5, TLR2
5	chronic inflammatory response to antigenic stimulus	GO:002439	10.0	IL1RN, IL1B
6	fever generation	GO:001660	10.0	IL1B, IL1A
7	negative regulation of T cell proliferation	GO:042130	10.0	TGFB1, IL10, SCGB1A1
8	positive regulation vascular endothelial growth factor production	GO:010575	9.9	TGFB1, IL1B, IL1A
9	embryo implantation	GO:007566	9.9	RECK, SCGB1A1, IL1B
10	positive regulation of interleukin-8 production	GO:032757	9.9	TLR5, TLR2, IL1B
11	regulation of sensory perception of pain	GO:051930	9.7	ADRB2, IL1A, IL10
12	response to ozone	GO:010193	9.7	IL1B, IL1A
13	acute-phase response	GO:006953	9.6	SERPINA1, IL1RN, MBL2
14	response to estradiol stimulus	GO:032355	9.6	TGFB1, NOS3, IL1B, SERPINA1
15	response to organic cyclic compound	GO:014070	9.5	NOS3, IL1RN, IL1A, SERPINA1
16	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.5	TNF, IL1B
17	response to organic nitrogen	GO:010243	9.4	IL1RN, IL1B, IL1A
18	sequestering of triglyceride	GO:030730	9.4	TNF, IL1B
19	innate immune response	GO:045087	9.4	TLR5, TLR2, TLR1, DMBT1, MBL2, IL1R1
20	protein kinase B signaling cascade	GO:043491	9.4	TGFB1, TNF, IL1B
21	receptor biosynthetic process	GO:032800	9.3	TNF, IL10
22	negative regulation of interleukin-6 production	GO:032715	9.2	BPI, IL10, TNF
23	positive regulation of NF-kappaB import into nucleus	GO:042346	9.2	TLR2, TNF, IL1B
24	cellular response to organic cyclic compound	GO:071407	9.2	TGFB1, TNF, IL1B
25	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.2	TNF, IL1B
26	defense response to bacterium	GO:042742	9.2	TLR1, RNASE3, NOS2, IL10, BPI
27	positive regulation of mitosis	GO:045840	9.1	TNF, IL1B, IL1A
28	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	TLR2, TNF, IL1B
29	defense response to Gram-positive bacterium	GO:050830	9.0	TLR2, TNF, MBL2
30	positive regulation of interleukin-6 production	GO:032755	9.0	IL1A, IL1B, TNF, TLR2
31	positive regulation of cytokine secretion	GO:050715	8.9	TLR2, TNF, IL1A, IL10
32	lipopolysaccharide-mediated signaling pathway	GO:031663	8.8	TGFB1, TLR2, NOS3, TNF, IL1B
33	immune response	GO:006955	8.5	CXCL6, TLR2, TLR1, PF4V1, IL8, IL1RN
34	response to glucocorticoid stimulus	GO:051384	8.5	TNF, IL1RN, IL1B, IL10
35	negative regulation of growth of symbiont in host	GO:044130	8.5	TLR2, ELANE, TNF, MBL2, IL10
36	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.4	TGFB1, TLR2, TNF, IL1B
37	negative regulation of cell proliferation	GO:008285	8.2	TGFB1, NOS3, TNF, IL8, IL1B, IL1A
38	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.2	GABPA, ADRB2, TGFB1, TLR2, TNF, IL1B
39	response to hypoxia	GO:001666	8.1	TGFB1, NOS3, NOS2, TNF, IL1B, IL1A
40	anti-apoptosis	GO:006916	7.8	NOS3, TNF, IL1B, IL1A, IL10, MPO
41	inflammatory response	GO:006954	7.1	IL10, CXCR1, CXCL6, TGFB1, TLR5, TLR2

Molecular functions related to cystic fibrosis lung disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	arginine binding	GO:034618	9.6	NOS2, NOS3
2	nitric-oxide synthase activity	GO:004517	9.5	NOS2, NOS3
3	tetrahydrobiopterin binding	GO:034617	9.3	NOS2, NOS3
4	interleukin-1 receptor binding	GO:005149	9.3	IL1A, IL1B, IL1RN, TLR5
5	protease binding	GO:002020	8.8	ELANE, TNF, IL1R1, SERPINA1
6	cytokine activity	GO:005125	8.0	TNF, IL1B, IL1A, IL17A, IL10