Cystic Kidney malady

MedlinePlus: A cyst is a fluid-filled sac. there are two types of kidney cysts. polycystic kidney disease (pkd) runs in families. in pkd, the cysts take the place of the normal tissue. they enlarge the kidneys and make them work poorly, leading to kidney failure. when pkd causes kidneys to fail - which usually happens after many years - people need dialysis or kidney transplantation. about half of people with the most common type of pkd end up with kidney failure. pkd also causes cysts in other parts of the body, such as the liver. symptoms of pkd include pain in the back and lower sides headaches urinary tract infections blood in the urine doctors diagnose pkd with imaging tests and family history. treatments include medications, and, when people with pkd develop kidney failure, dialysis or kidney transplants. acquired cystic kidney disease (ackd) usually happens in people who are on dialysis. unlike pkd, the kidneys are normal sized, and cysts do not form in other parts of the body. people with ackd already have chronic kidney disease when they develop cysts. ackd often has no symptoms. in most cases, the cysts are harmless and do not need treatment. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Cystic Kidney, also known as cystic kidney disease, is related to nephronophthisis and umod-associated kidney disease. An important gene associated with Cystic Kidney is UMOD (uromodulin), and among its related pathways are Selected targets of HNF1 and CCKBR-Gastrin Stimulated Signaling. The compounds trp-p-2 and pd 145065 have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia: Cystic kidney disease refers to a wide range of hereditary, developmental, and acquired conditions. With...⁴⁴ more...

Aliases & Descriptions:

cystic kidney 6 8 43 cystic kidney disease 6 32 kidney cysts 17 23 renal cyst 6 32 cystic disease of kidney (disorder) 6

congenital cystic kidney disease 43 cystic kidney diseases 43 cystic disease, nos 43 kidney cyst 6

Diseases related to cystic kidney by text searches and GeneDecks gene sharing:

(show top 50)    (show all 136)

id	Related Disease	Score	Top Affiliating Genes
1	nephronophthisis	33.9	UMOD, PKD1, PKD2
2	umod-associated kidney disease	33.1	UMOD, MCKD2
3	familial juvenile hyperuricaemic nephropathy	31.5	UMOD, MCKD2
4	polycystic kidney disease	29.3	PKD1, PKHD1
5	glomerulocystic kidney disease	29.3	UMOD, MCKD2, HNF1B
6	polycystic liver disease	29.3	PKD1, PKD2, PKHD1
7	familial juvenile hyperuricemic nephropathy	29.1	UMOD, HNF1B
8	renal cell carcinoma	28.3	VHL, CLU, UMOD, JUN, CCL26, HNF1B
9	end stage renal failure	27.8	UMOD, XPNPEP3, ALB, NPHP4, EPO
10	von hippel-lindau disease	27.0	REN, VHL, CLU, PKD1, TSC2, EPO
11	chronic kidney failure	26.9	REN, ALB, EPO
12	nephropathy	25.8	REN, CLU, UMOD, XPNPEP3, JUN, CD14
13	anemia	25.8	REN, CNTLN, VHL, CLU, XPNPEP3, CD14
14	obesity	23.8	REN, CLU, CEP290, JUN, CD14, MKS1
15	pancreatitis	21.8	REN, VHL, CLU, JUN, CD14, INVS
16	carcinoma	21.0	REN, VHL, CLU, BCAR1, UMOD, JUN
17	glomerulocystic kidney disease with hyperuricemia and isosthenuria	13.8	UMOD, MCKD2
18	polycystic kidney disease 2, autosomal dominant	13.8	PKD1, PKD2
19	polycystic kidney disease, autosomal dominant	13.7	PKD1, PKD2
20	renal-hepatic-pancreatic dysplasia	13.7	INVS, PKHD1, NPHP3
21	nephronophthisis 4	13.7	NPHP1, NPHP4
22	polycystic kidney disease, autosomal recessive	13.7	IFT88, PKHD1
23	toxic epidermal necrolysis	13.6	EDNRA, EDNRB
24	nephronopthisis	13.6	UMOD, ANKS6, NPHP1, NPHP3, NPHP4
25	exfoliation syndrome	13.6	CLU, EDNRA, EDNRB
26	situs inversus	13.5	KIF3A, INVS, PKD2, NPHP1, NPHP3, NPHP4
27	angiomatosis	13.5	VHL, CCL26, TSC2
28	cep290-related bardet-biedl syndrome	13.4	CEP290, TMEM67
29	nephronophthisis 1	13.4	BCAR1, INVS, PKD1, AHI1, NPHP1, NPHP3
30	rhyns syndrome	13.4	CEP290, NPHP1, NPHP4, NPR1
31	coach syndrome	13.4	CC2D2A, TMEM67, RPGRIP1L
32	orofaciodigital syndrome	13.4	KIF3A, CEP290, IFT88, OFD1
33	congenital hepatic fibrosis	13.3	CC2D2A, TMEM67, RPGRIP1L, PKHD1
34	coloboma	13.0	CEP290, CC2D2A, TMEM67, RPGRIP1L, NPHP1
35	aortic disease	12.9	REN, CCL26, TSC2
36	joubert syndrome and related disorders	12.9	CEP290, INVS, CC2D2A, TMEM67, RPGRIP1L, AHI1
37	cerebellar ataxia	12.8	ARL13B, CC2D2A, TMEM67, OFD1, RPGRIP1L, AHI1
38	fundus dystrophy	12.8	CEP290, ARL13B, CC2D2A, TMEM67, RPGRIP1L, AHI1
39	encephalocele	12.8	B9D1, B9D2, CEP290, MKS1, CC2D2A, TMEM67
40	encephaloceles	12.8	B9D1, B9D2, CEP290, MKS1, CC2D2A, TMEM67
41	meckel syndrome	12.8	B9D1, B9D2, CEP290, MKS1, CC2D2A, TMEM67
42	leber congenital amaurosis	12.8	CNTLN, CEP290, TMEM67, RPGRIP1L, NPHP3, NPHP4
43	stickler syndrome	12.7	CEP290, JUN, EGF, NPHP1, NPHP4
44	asphyxiating thoracic dystrophy	12.7	ARL13B, INVS, CC2D2A, TMEM67, OFD1, RPGRIP1L
45	small cell carcinoma	12.7	CD14, ALB, HNF1B, TSC2, NEK8
46	bardet-biedl syndrome	12.7	KIF3A, CEP290, MKS1, ARL13B, INVS, IFT88
47	multicystic renal dysplasia, bilateral	12.7	REN, CEP290, MKS1, TMEM67
48	mayer-rokitansky-kuster-hauser syndrome	12.7	VHL, CCL26, PKD1, PKD2, EDNRB, TSC2
49	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	12.6	CEP290, ARL13B, CC2D2A, TMEM67, OFD1, RPGRIP1L
50	oculomotor apraxia	12.6	CEP290, ARL13B, CC2D2A, TMEM67, OFD1, RPGRIP1L

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to cystic kidney:

²²

MGI Mouse Phenotypes related to cystic kidney:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	NEK1, NPR1, EDNRA, PKD2, IFT88, BICC1
2	hematopoietic system phenotype	MP:0005397	8.6	EPO, NEK1, NPHP3, TSC2, PKHD1, INVS
3	liver/biliary system phenotype	MP:0005370	8.6	HNF1B, RPGRIP1L, PKD1, PKD2, TSC2, EPO
4	limbs/digits/tail phenotype	MP:0005371	8.0	PTK2, OFD1, RPGRIP1L, PKD1, EDNRB, IFT88
5	vision/eye phenotype	MP:0005391	7.9	RPGRIP1L, EDNRB, EGF, AHI1, NPHP1, NPHP4
6	skeleton phenotype	MP:0005390	7.9	OFD1, RPGRIP1L, PKD1, EDNRA, EDNRB, NPHP3
7	muscle phenotype	MP:0005369	7.8	PRKD1, EDNRB, EDNRA, PKD1, PTK2, HNF1B
8	craniofacial phenotype	MP:0005382	7.8	RPGRIP1L, PKD1, EDNRA, EDNRB, NPHP3, NEK1
9	embryogenesis phenotype	MP:0005380	7.4	CC2D2A, IFT88, TMEM67, PTK2, OFD1, RPGRIP1L
10	respiratory system phenotype	MP:0005388	7.4	OFD1, RPGRIP1L, PKD1, PKD2, PKHD1, EDNRA
11	digestive/alimentary phenotype	MP:0005381	7.2	OFD1, PKD1, PKD2, PKHD1, EDNRA, EDNRB
12	immune system phenotype	MP:0005387	6.2	PKD1, PKD2, PKHD1, EDNRA, EDNRB, EGF
13	cellular phenotype	MP:0005384	6.2	PKD1, PKD2, PKHD1, EDNRB, AHI1, TSC2
14	nervous system phenotype	MP:0003631	5.6	OFD1, RPGRIP1L, PKD1, PKHD1, EDNRA, EDNRB
15	renal/urinary system phenotype	MP:0005367	5.5	NEK8, ALB, IFT88, INVS, FJX1, MKS1
16	cardiovascular system phenotype	MP:0005385	5.4	RPGRIP1L, PKD1, PKD2, PKHD1, EDNRA, EDNRB
17	growth/size phenotype	MP:0005378	4.4	PKD1, RPGRIP1L, OFD1, PTK2, TMEM67, HNF1B
18	homeostasis/metabolism phenotype	MP:0005376	4.2	PTK2, PKD1, PKD2, EDNRA, EDNRB, AHI1
19	mortality/aging	MP:0010768	2.9	EPO, NEK8, NEK1, REN, IFT88, INVS

Articles related to cystic kidney:

(show all 27)

id	Title	Authors	Year	Affiliating Genes
1	Renal CD14 expression correlates with the progression of cystic kidney disease. (20555320)	Zhou J.... Mrug M.	2010	CD14
2	Lethal cystic kidney disease in Amish neonates associated with homozygous nonsense mutation of NPHP3. (19303681)	Simpson M.A.... Crosby A.H.	2009	NPHP3
3	Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. (18604206)	Saburi S.... McNeill H.	2008	FJX1
4	Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. (17825558)	Davenport J.R.... Yoder B.K.	2007	IFT88
5	TSC2, a key player in tumor suppression and cystic kidney disease. (17373211)	Cai S.L.... Walker C.L.	2006	TSC2, PKD1
6	C-jun activation in acquired cystic kidney disease and renal cell carcinoma. (16006965)	Oya M.... Murai M.	2005	JUN
7	Clinico-pathologic findings in medullary cystic kidney disease type 2. (15844001)	Bleyer A.J.... Trachtman H.	2005	UMOD
8	A novel pattern of mutation in uromodulin disorders: autosomal dominant medullary cystic kidney disease type 2, familial juvenile hyperuricemic nephropathy, and autosomal dominant glomerulocystic kidney disease. (15983957)	Lens X.M.... Barrio-Lucia V.	2005	UMOD
9	Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1 beta) mutations. (16932376)	Lebrun G.... Grunfeld J.P.	2005	HNF1B
10	A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. (15269167)	Sun Z.... Hopkins N.	2004	HNF1B
11	Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney disease. (12832729)	Scolari F.... Casari G.	2003	UMOD, NPHP1, MCKD1
12	Nephronophthisis-medullary cystic kidney disease: from bedside to bench and back again. (17657103)	Scolari F.... Ghiggeri G.M.	2003	NPHP1
13	Molecular analysis of uromodulin and SAH genes, positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12. (12839032)	Casari G.... Amoroso A.	2003	UMOD
14	Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. (12471200)	Hart T.C.... Bleyer A.J.	2002	UMOD
15	Pathogenesis of cystic kidney diseases (12647363)	Walz G.	2002	TSC2, VHL, PKD1
16	The genes and proteins associated with poly-cystic kidney diseases. (12536190)	Wilson P.D.	2002	PTK2, PKD2, NPHP1
17	Novel NPR1 polymorphic variants and its exclusion as a candidate gene for medullary cystic kidney disease (ADMCKD) type 1. (11851379)	Koptides M.... Deltas C.C.	2001	NPR1, MCKD1
18	Further evidence for linkage of autosomal-dominant me dullary cystic kidney disease on chromosome 1q21. (11576336)	Auranen M.... JAorvelAo I.	2001	NPR1
19	New insights: nephronophthisis-medullary cystic kidney disease. (11261687)	Hildebrandt F.... Omram H.	2001	NPHP1, INVS, NPHP3
20	Molecular analysis of uromodulin and SAH genes, positional candidates for autosomal dominant medullary cystic kidney disease linked to 16p12. (11730273)	Pirulli D.... Casari G.	2001	UMOD
21	Molecular genetics of nephronophthisis and medullary cystic kidney disease. (10966501)	Hildebrandt F.... Otto E.	2000	NPHP1
22	Obstructive nephropathy: lessons from cystic kidney disease. (10644902)	Chevalier R.L.	2000	EGF, CLU
23	Chromosome 1 localization of a gene for autosomal dominant medullary cystic kidney disease. (9536096)	Christodoulou K.... Constantinou Deltas C.	1998	MCKD1
24	Change in prostanoid metabolism in cystic kidney lesion (9606841)	Komarevtseva I.A.... SenchiA- V.N.	1997	REN
25	Severity of acquired cystic kidney disease determines improvement in chronic kidney failure anemia (9224984)	Bezerra H.M.... de Almeida J.B.	1997	ALB
26	Acquired cystic kidney disease: the hormonal hypothes is. (8497993)	Concolino G.... Di Silverio F.	1993	EGF
27	Anemia in dialysis: its relation to acquired cystic kidney disease and serum levels of erythropoietin. (2048573)	FAcrnandez A.... Palop L.	1991	EPO

Genes related to cystic kidney according to GeneCards:

(show top 50)    (show all 55)

id	Symbol	Description	Score	GeneCards Section Context
1	UMOD	uromodulin	11.1	Summaries, Publications
2	MCKD1	medullary cystic kidney disease 1 (autosomal dominant)	11.1	Aliases & Descriptions, Publications
3	MCKD2	medullary cystic kidney disease 2 (autosomal dominant)	11.1	Aliases & Descriptions
4	PKD2	polycystic kidney disease 2 (autosomal dominant)	11.0	Publications
5	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0	Publications
6	NPHP3	nephronophthisis 3 (adolescent)	11.0	Publications
7	NPHP1	nephronophthisis 1 (juvenile)	11.0	Publications
8	HNF1B	HNF1 homeobox B	11.0	Publications
9	INVS	inversin	11.0	Publications
10	BCAR1	breast cancer anti-estrogen resistance 1	11.0
11	NPHP4	nephronophthisis 4	11.0
12	EDNRB	endothelin receptor type B	11.0
13	TSC2	tuberous sclerosis 2	11.0	Publications
14	EDNRA	endothelin receptor type A	11.0
15	PKHD1	polycystic kidney and hepatic disease 1 (autosomal recessive)	11.0	Publications
16	PKD1P6	polycystic kidney disease 1 (autosomal dominant) pseudogene 6	11.0
17	FJX1	four jointed box 1 (Drosophila)	11.0	Publications
18	NXPH4	neurexophilin 4	11.0
19	B9D2	B9 protein domain 2	11.0
20	MKS1	Meckel syndrome, type 1	11.0
21	GLIS2	GLIS family zinc finger 2	11.0
22	NEK8	NIMA (never in mitosis gene a)- related kinase 8	11.0
23	B9D1	B9 protein domain 1	11.0
24	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	11.0	Publications
25	NEK9	NIMA (never in mitosis gene a)- related kinase 9	11.0	Disorders
26	IFT88	intraflagellar transport 88 homolog (Chlamydomonas)	11.0	Publications, Orthologs
27	OFD1	oral-facial-digital syndrome 1	11.0
28	WDR35	WD repeat domain 35	11.0
29	XPNPEP3	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	11.0
30	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
31	ARL13B	ADP-ribosylation factor-like 13B	11.0
32	ANKS6	ankyrin repeat and sterile alpha motif domain containing 6	11.0
33	KIF3A	kinesin family member 3A	11.0
34	TMEM67	transmembrane protein 67	11.0
35	BMPER	BMP binding endothelial regulator	11.0
36	CLU	clusterin	11.0	Publications
37	CEP290	centrosomal protein 290kDa	11.0
38	RPGRIP1L	RPGRIP1-like	11.0
39	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
40	CC2D2A	coiled-coil and C2 domain containing 2A	11.0
41	PACS1	phosphofurin acidic cluster sorting protein 1	11.0
42	KIAA0586	KIAA0586	11.0	Disorders
43	AHI1	Abelson helper integration site 1	11.0
44	NEK1	NIMA (never in mitosis gene a)-related kinase 1	11.0
45	BICC1	bicaudal C homolog 1 (Drosophila)	11.0
46	CD14	CD14 molecule	11.0	Publications
47	PRKD1	protein kinase D1	11.0
48	CNTLN	centlein, centrosomal protein	11.0
49	EGF	epidermal growth factor	11.0	Publications
50	JUN	jun proto-oncogene	11.0	Publications

Pathways related to cystic kidney according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	9.5	PKD2, HNF1B, ALB, UMOD
2	CCKBR-Gastrin Stimulated Signaling36	8.8	BCAR1, JUN, PTK2, EGF
3	Signal transduction PTEN pathway10	8.7	BCAR1, TSC2, EGF, PTK2, JUN
4	Signal transduction_PTEN pathway41	8.6	TSC2, EGF, PTK2, JUN, BCAR1

Compounds related to cystic kidney according to GeneDecks:

(show all 31)

id	Compound	Score	Top Affiliating Genes
1	trp-p-232	10.6	PKD2, PKD1
2	pd 14506532	10.4	EDNRB, EDNRA
3	sitaxsentan32	10.3	EDNRB, EDNRA
4	darusentan32	10.1	EDNRB, EDNRA, REN
5	cocl232	10.0	EPO, EDNRA, VHL
6	ornipressin32	9.6	ALB, REN
7	inulin32	9.5	REN, CLU, ALB
8	aminoguanidine32 9 9	11.4	EPO, ALB, CLU
9	cobalt chloride32	9.2	VHL, PTK2, EDNRA, EPO
10	rapamycin32 42	10.1	TSC2, EGF, PKD1, PTK2, CCL26, VHL
11	ro 31 822032	9.1	EGF, PTK2, JUN
12	irbesartan32 9 9	11.0	ALB, JUN, REN
13	ang ii32	8.9	EGF, EDNRA, PTK2, REN
14	losartan32 34 9 9	11.9	EDNRB, EDNRA, ALB, REN
15	rottlerin32 42	9.8	PRKD1, EGF, PTK2, JUN
16	herbimycin a32 42	9.7	EGF, PTK2, CD14, JUN, BCAR1
17	vitamin d32	8.7	EPO, NPR1, EDNRA, ALB, CD14, JUN
18	phosphoinositide32	8.5	PRKD1, TSC2, EGF, EDNRA, PTK2, JUN
19	sodium32 18	9.4	NPR1, EDNRB, EDNRA, PKD2, PKD1, PTK2
20	wortmannin32 42	9.4	PRKD1, TSC2, EGF, EDNRA, PTK2, CD14
21	steroid32	8.1	TSC2, EGF, EDNRB, EDNRA, PTK2, CD14
22	ly29400232	8.0	EPO, TSC2, EGF, PTK2, CD14, JUN
23	oxygen32 18	8.8	EPO, PRKD1, TSC2, EDNRB, EDNRA, PTK2
24	pge232	7.8	EDNRB, EDNRA, PTK2, CD14, JUN, REN
25	butyrate32	7.8	EPO, EGF, PTK2, CD14, JUN, CLU
26	cysteine32	7.6	NPR1, EGF, EDNRB, EDNRA, PTK2, ALB
27	phosphatidylinositol32	7.5	EDNRB, EGF, TSC2, PRKD1, EPO, EDNRA
28	serine32	7.3	EDNRB, EGF, TSC2, PRKD1, NPR1, NEK1
29	calcitriol32 42 9 18 9	11.1	EPO, EGF, PTK2, ALB, CD14, JUN
30	vegf32	6.8	REN, EPO, PRKD1, TSC2, EGF, EDNRB
31	calcium32 9 18 9	9.7	PKD1, PKD2, PKHD1, EDNRA, EDNRB, EGF

Cellular components related to cystic kidney according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	motile primary cilium	GO:031512	10.3	PKD2, PKD1, IFT88
2	photoreceptor connecting cilium	GO:032391	10.1	CEP290, IFT88, NPHP1
3	polycystin complex	GO:002133	10.0	PKD1, PKD2
4	primary cilium	GO:072372	9.9	NEK8, NPHP3, AHI1, PKHD1, UMOD, KIF3A
5	cilium axoneme	GO:035085	9.9	NPHP1, RPGRIP1L, IFT88, B9D2, B9D1, WDR35
6	cell-cell junction	GO:005911	9.6	NPHP4, NPHP1, PRKD1, AHI1, PKD2, RPGRIP1L
7	cilium	GO:005929	9.6	NPHP4, NPHP3, AHI1, PKD2, PKD1, RPGRIP1L
8	TCTN-B9D complex	GO:036038	9.5	AHI1, TMEM67, CC2D2A, MKS1, CEP290, B9D2
9	centriole	GO:005814	9.5	AHI1, OFD1, IFT88, CNTLN
10	microtubule basal body	GO:005932	8.7	WDR35, NPHP4, AHI1, PKHD1, PKD2, RPGRIP1L
11	centrosome	GO:005813	8.1	OFD1, RPGRIP1L, PKHD1, AHI1, NPHP4, NEK1
12	extracellular space	GO:005615	7.5	EPO, EGF, ALB, CCL26, FJX1, CD14

Biological processes related to cystic kidney according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	metanephric ascending thin limb development	GO:072218	10.5	UMOD, PKD1, PKD2
2	mesonephric tubule development	GO:072164	10.3	PKD1, PKD2
3	endothelin receptor signaling pathway	GO:086100	10.2	EDNRB, EDNRA
4	determination of left/right symmetry	GO:007368	10.1	NPHP3, PKD2, RPGRIP1L, IFT88, ARL13B
5	visual behavior	GO:007632	10.0	NPHP1, NPHP4
6	branching morphogenesis of a tube	GO:048754	10.0	EGF, PKD1, HNF1B, MKS1
7	hindbrain development	GO:030902	10.0	CEP290, HNF1B, AHI1
8	kidney development	GO:001822	9.5	PKHD1, PKD1, RPGRIP1L, HNF1B, INVS, REN
9	cilium morphogenesis	GO:060271	9.3	NPHP3, AHI1, OFD1, TMEM67, IFT88, CC2D2A
10	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO:2000060	9.2	CLU, PTK2, EGF
11	cilium assembly	GO:042384	8.7	WDR35, NEK1, AHI1, PKHD1, RPGRIP1L, TMEM67
12	negative regulation of apoptotic process	GO:043066	8.1	EPO, AHI1, EDNRA, PTK2, HNF1B, ALB

Molecular functions related to cystic kidney according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endothelin receptor activity	GO:004962	10.3	EDNRA, EDNRB
2	protein binding	GO:005515	4.0	KIF3A, PKD1, PKD2, PKHD1, EGF, AHI1