MCID: CYS002
MIFTS: 44

Cystic Lymphangioma malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Cystic Lymphangioma

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Aliases & Descriptions for Cystic Lymphangioma:

Name: Cystic Lymphangioma 11 47 13
Cystic Hygroma 11 47 26
Macrocystic Lymphatic Malformation 47 53
Cavernous Lymphangioma 53 67
 
Lymphangioma, Cystic 38 67
Cavernous Lymphatic Malformation 53
Macrocystic Lymphangioma 53

Characteristics:

Orphanet epidemiological data:

53
macrocystic lymphatic malformation:
Inheritance: Not applicable; Age of onset: Infancy,Neonatal

Classifications:



External Ids:

Disease Ontology11 DOID:3081
MeSH38 D018191
NCIt44 C3724
Orphanet53 ORPHA79489
ICD10 via Orphanet30 D18.1

Summaries for Cystic Lymphangioma

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MalaCards based summary: Cystic Lymphangioma, also known as cystic hygroma, is related to cavernous lymphangioma and abdominal cystic lymphangioma, and has symptoms including pain of lymph node An important gene associated with Cystic Lymphangioma is IFNG (Interferon Gamma), and among its related pathways are PDGFR-alpha signaling pathway and Glucocorticoid receptor regulatory network. Affiliated tissues include pancreas, colon and spleen, and related mouse phenotype muscle.

Related Diseases for Cystic Lymphangioma

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Diseases related to Cystic Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous lymphangioma12.2
2abdominal cystic lymphangioma12.2
3cystic hygroma lethal cleft palate12.0
4nuchal bleb, familial12.0
5mixed cystic lymphatic malformation10.9
6lymphangioma10.9
7calcaneonavicular coalition10.3IFNG, PIK3CA
8stampe sorensen syndrome10.2IFNG, PIK3CA
9mediastinitis10.2
10lymphatic malformations10.2
11anus adenocarcinoma10.2AFP, PIK3CA
12pancreatitis10.2
13atypical lipomatous tumor10.1AFP, NODAL
14cervicitis10.1
15taylor's syndrome10.1AFP, IFNG
16hypertrichosis of eyelid10.1AFP, NODAL
17primary angle-closure glaucoma10.0AFP, CHRNG
18gallbladder papillomatosis10.0AFP, PIK3CA
19appendicitis10.0
20perianal skin paget's disease9.9AFP, IFNG
21duodenitis9.9
22multiple system atrophy, parkinsonian type9.9CHRND, DOK7
23myelofibrosis9.8CHRNG, DOK7
24hepatitis9.8
25cystic teratoma9.8
26teratoma9.8
27adenomatoid tumor9.8
28intestinal obstruction9.8
29intussusception9.8
30hemangioendothelioma9.8
31splenomegaly9.8
32granulomatous dermatitis9.7CHRND, DOK7
33inverted transitional papilloma9.7DOK7, FLVCR2, NODAL
34hodgkin lymphoma9.6
35celiac disease9.6
36cystic fibrosis9.6
37blue rubber bleb nevus9.6
38jejunal atresia9.6
39hemangioma9.6
40lymphoma9.6
41esophagitis9.6
42hiatus hernia9.6
43urethritis9.6
44pneumothorax9.6
45seminoma9.6
46ureteral obstruction9.6
47subacute thyroiditis9.6
48thyroiditis9.6
49peritonitis9.6
50choledochal cyst9.6

Graphical network of the top 20 diseases related to Cystic Lymphangioma:



Diseases related to cystic lymphangioma

Symptoms for Cystic Lymphangioma

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UMLS symptoms related to Cystic Lymphangioma:


pain of lymph node

Drugs & Therapeutics for Cystic Lymphangioma

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Drugs for Cystic Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2
PancrelipaseapprovedEarly Phase 193553608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
3pancreatinEarly Phase 1935

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2AVAST Anomalies Vasculaires AssociƩes au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
3Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Early Phase 1

Search NIH Clinical Center for Cystic Lymphangioma


Cochrane evidence based reviews: lymphangioma, cystic

Genetic Tests for Cystic Lymphangioma

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Genetic tests related to Cystic Lymphangioma:

id Genetic test Affiliating Genes
1 Cystic Hygroma26

Anatomical Context for Cystic Lymphangioma

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MalaCards organs/tissues related to Cystic Lymphangioma:

35
Pancreas, Colon, Spleen, Breast, Adrenal gland, Lymph node, Tongue

Animal Models for Cystic Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Cystic Lymphangioma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2CHRNG, DOK7, IFNG, NODAL, PIK3CA

Publications for Cystic Lymphangioma

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Articles related to Cystic Lymphangioma:

(show top 50)    (show all 399)
idTitleAuthorsYear
1
CT Appearance of Adrenal Cystic Lymphangioma: Radiologic-Pathologic Correlation. (26700338)
2016
2
A sudden pain in the neck: an atypical presentation of cystic lymphangioma. (25795753)
2015
3
Treatment of cystic lymphangioma by transcatheter lymphatic sclerotherapy and embolization. (25735533)
2015
4
Identification of a pediatric intra-abdominal cystic lymphangioma using point-of-care ultrasonography. (25560624)
2015
5
Unusual sites of cystic lymphangioma in children. (25282458)
2014
6
An unusual cause of abdominal pain: duodenal cystic lymphangioma. (23961273)
2013
7
Cystic fibrosis and retroperitoneal cystic lymphangioma: a novel match. (22273284)
2012
8
A case of laparoscopic excision of a huge retroperitoneal cystic lymphangioma. (22606623)
2011
9
Cystic lymphangioma of the pancreas with congenital intrahepatic duct dilatation and choledochal cyst. (21213336)
2011
10
Cystic lymphangioma of the pancreas with spontaneous rupture: report of a case. (21712979)
2011
11
Cystic lymphangioma of the pancreas: diagnostic and therapeutic challenges. (21068498)
2010
12
Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: Case presentation and review of the literature. (19851133)
2009
13
Fetal cystic lymphangioma of the neck: a case report. (22439033)
2009
14
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
15
Lingual cystic lymphangioma in an elderly patient. (19052498)
2008
16
Cystic lymphangioma of the lesser sac presenting as acute appendicitis: A case report. (18783617)
2008
17
Retroperitoneal cystic lymphangioma. (23133047)
2008
18
Cystic lymphangioma of the leg in a child with agenesis of testis. (17989641)
2007
19
Non surgical management of cystic lymphangioma. (23120346)
2006
20
Two cases of cystic lymphangioma of the pancreas: a rare finding in endoscopic ultrasonography. (17366391)
2006
21
Gastrointestinal: mesenteric cystic lymphangioma. (16704547)
2006
22
Total laparoscopic excision of retroperitoneal cystic lymphangioma. (17004884)
2006
23
Hepatobiliary and pancreatic: Cystic lymphangioma of the pancreas. (16638110)
2006
24
Cystic lymphangioma of the breast. (16297123)
2005
25
Retroperitoneal cystic lymphangioma. (15932454)
2005
26
Cystic lymphangioma of the greater omentum and ascites: an unusual combination. (15386458)
2004
27
Mesenteric cystic lymphangioma causing intestinal occlusion in an adult patient. (14722994)
2003
28
Asymptomatic adult cystic lymphangioma of the spleen: case report and review of the literature. (12620551)
2003
29
Cystic lymphangioma of the pancreas: anatomoclinical, diagnostic and therapeutic considerations regarding three personal observations and review of the literature. (14571816)
2003
30
Giant cystic lymphangioma of the stomach. (11841086)
2001
31
Huge cystic lymphangioma of the pancreas: report of a case. (11510617)
2001
32
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
33
Cystic lymphangioma in an asymptomatic newborn: an uncommon localization in the ileum. (10204513)
1999
34
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
35
Progressive fetal axillary cystic lymphangioma with coexistent naevus flammeus. (9039304)
1997
36
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
37
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
38
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
39
Laparoscopic observation of retroperitoneal cystic lymphangioma. (8003655)
1994
40
Case report: giant tuberculous cystic lymphangioma of posterior mediastinum, retroperitoneum and groin. (8143418)
1994
41
Cystic lymphangioma of the kidney: a rare cause of multiloculated renal masses. (1999216)
1991
42
Abdominal cystic lymphangioma. A case report and a review of the literature. (2180901)
1990
43
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
44
Cystic lymphangioma of the colon. Report of a case and review of the literature. (6489077)
1984
45
Recurrent massive cystic lymphangioma. (114944)
1978
46
Solitary cystic lymphangioma of the retroperitoneum. (904040)
1977
47
Cystic lymphangioma of the mediastinum and the small bowel: a case report and a review of literature. (913723)
1977
48
Case report: Cystic lymphangioma of the vallecula. (1131722)
1975
49
Ureteral obstruction due to retroperitoneal lymphatic cyst (cystic lymphangioma). (13655395)
1959
50
Cystic lymphangioma of lungs as result of relapsing tensional pneumothorax]. (13039085)
1952

Variations for Cystic Lymphangioma

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Expression for genes affiliated with Cystic Lymphangioma

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Search GEO for disease gene expression data for Cystic Lymphangioma.

Pathways for genes affiliated with Cystic Lymphangioma

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Pathways related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8IFNG, PIK3CA
29.7AFP, IFNG

GO Terms for genes affiliated with Cystic Lymphangioma

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Cellular components related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:00058929.5CHRND, CHRNG
2cell junctionGO:00300548.6CHRND, CHRNG, DOK7

Biological processes related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:006039510.1AFP, NODAL
2vasculature developmentGO:00019449.9NODAL, PIK3CA
3synaptic transmission, cholinergicGO:00072719.6CHRND, CHRNG
4neuromuscular synaptic transmissionGO:00072749.6CHRND, CHRNG
5cation transmembrane transportGO:00986559.5CHRND, CHRNG
6liver developmentGO:00018899.4AFP, NODAL, PIK3CA
7chemical synaptic transmission, postsynapticGO:00995659.0CHRND, CHRNG
8response to nicotineGO:00350948.7CHRND, CHRNG
9transportGO:00068108.5AFP, CHRND, CHRNG

Molecular functions related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:00048899.3CHRND, CHRNG
2acetylcholine receptor activityGO:00154649.2CHRND, CHRNG
3acetylcholine bindingGO:00421669.1CHRND, CHRNG
4ligand-gated ion channel activityGO:00152769.0CHRND, CHRNG

Sources for Cystic Lymphangioma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet