MCID: CYS002
MIFTS: 40

Cystic Lymphangioma malady

Categories: Rare diseases, Cardiovascular diseases, Skin diseases, Fetal diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Cystic Lymphangioma

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Aliases & Descriptions for Cystic Lymphangioma:

Name: Cystic Lymphangioma 10 12
Cystic Hygroma 10 45 51
 
Lymphangioma, Cystic 36 65

Characteristics:

Orphanet epidemiological data:

51
cystic hygroma:
Inheritance: Not applicable; Age of onset: Infancy,Neonatal

Classifications:



External Ids:

Disease Ontology10 DOID:3081
MeSH36 D018191
NCIt42 C3724
Orphanet51 79486
ICD10 via Orphanet28 D18.1
UMLS65 C0206620

Summaries for Cystic Lymphangioma

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NIH Rare Diseases:45 Cystic hygroma (meaning “moist tumor”) are fluid-filled sacs that result from a blockage in the lymphatic system, often in the head and neck area. a cystic hygroma may be discovered in a fetus during a pregnancy ultrasound, present as a birth defect (congenital) in a newborn, or it may not become evident until later in life. the causes include environmental factors, genetic factors, or unknown factors. the majority of prenatally diagnosed cystic hygromas are due to a chromosomal abnormality known as turner syndrome, in which a female has only one x chromosome instead of two. when a cystic hygroma is identified in a fetus, parents are counseled regarding their baby's risk for having a chromosome problem or other birth defect, and are offered additional testing options such as special ultrasound tests or amniocentesis. cystic hygromas can occur as an isolated finding or with other birth defect as part of a syndrome. isolated cystic hygroma may be inherited as an autosomal recessive disorder. a fetal cystic hygroma may progress to hydrops (an excess amount of fluid in the body) and eventually to fetal death. cystic hygromas in infants, children, or adults may enlarge or become infected, and may require surgery or other therapy to remove or shrink the mass. fetal cystic hygroma may be treated with serial thoracocentesis plus paracentesis. last updated: 2/26/2016

MalaCards based summary: Cystic Lymphangioma, also known as cystic hygroma, is related to multiple pterygium syndrome, lethal type and mycosis fungoides. An important gene associated with Cystic Lymphangioma is IFNG (Interferon, Gamma), and among its related pathways are PDGFR-alpha signaling pathway and Glucocorticoid receptor regulatory network. Affiliated tissues include testes, skin and lung, and related mouse phenotype muscle.

Related Diseases for Cystic Lymphangioma

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Graphical network of the top 20 diseases related to Cystic Lymphangioma:



Diseases related to cystic lymphangioma

Symptoms for Cystic Lymphangioma

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Drugs & Therapeutics for Cystic Lymphangioma

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Drugs for Cystic Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2
PancrelipaseapprovedPhase 088053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
3pancreatinPhase 0880

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
3Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Phase 0

Search NIH Clinical Center for Cystic Lymphangioma


Cochrane evidence based reviews: lymphangioma, cystic

Genetic Tests for Cystic Lymphangioma

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Anatomical Context for Cystic Lymphangioma

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MalaCards organs/tissues related to Cystic Lymphangioma:

33
Testes, Skin, Lung, Breast, Endothelial, Liver, Kidney

Animal Models for Cystic Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Cystic Lymphangioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2CHRNG, DOK7, IFNG, NODAL, PIK3CA

Publications for Cystic Lymphangioma

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Articles related to Cystic Lymphangioma:

(show top 50)    (show all 378)
idTitleAuthorsYear
1
An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America. (27162270)
2016
2
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. (27076310)
2016
3
Re: Cytoreductive Nephrectomy in Patients with Synchronous Metastases fromA Renal Cell Carcinoma: Results from the International Metastatic Renal CellA Carcinoma Database Consortium. (25895755)
2015
4
The role of local and systemic cytokines in patients infected with Clostridium difficile. (25371529)
2014
5
Clinical relevance of tag single nucleotide polymorphisms within the CAT gene in patients with PTSD in the Chongqing Han population. (24817970)
2014
6
The role of genetic polymorphisms in endothelial nitric oxide synthase and beta2-adrenergic receptors with risk of hypertension in a sample of Lebanese people. (24623205)
2014
7
Cervical intradural paraganglioma presenting as progressive cervicodynia: case report and literature review. (22721774)
2013
8
CD133 silencing inhibits stemness properties and enhances chemoradiosensitivity in CD133-positive liver cancer stem cells. (23233126)
2013
9
The epidermal growth factor-like domain of CD93 is a potent angiogenic factor. (23272129)
2012
10
Staged approach for spinal cord protection in hybrid thoracoabdominal aortic aneurysm repair. (23977515)
2012
11
Haptoglobin: basic and clinical aspects. (19659435)
2010
12
A case of Takotsubo cardiomyopathy in a patient with iatrogenic thyrotoxicosis. (19628289)
2010
13
Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population. (20599479)
2010
14
The association of bullous pemphigoid with cerebrovascular disease and dementia: a case-control study. (21079062)
2010
15
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. (18991182)
2009
16
Dexamethasone phosphate in antibiotic ear drops for the treatment of acute bacterial otitis externa. (18606053)
2008
17
Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. (18322243)
2008
18
Liver transplantation in the setting of hepatocellular carcinoma and portal vein thrombosis: a challenging dilemma? (18080191)
2008
19
Therapeutic uses of aromatase inhibitors in men. (17940445)
2007
20
Ovarian inflammatory myofibroblastic tumor in children. (18082859)
2007
21
Opsoclonus persisting during sleep in West Nile encephalitis. (16966514)
2006
22
TNF-alpha induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR-gamma agonist pioglitazone. (16762982)
2006
23
Whole-body positron emission tomography and tumor marker CA125 for detection of recurrence in epithelial ovarian cancer. (16515575)
2006
24
Reproducibility of MDM2 and CDK4 staining in soft tissue tumors. (16707369)
2006
25
Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis. (16200419)
2005
26
Multivariate analysis of factors associated with renal dysfunction in patients with obstructive jaundice. (16078295)
2005
27
Life threatening tongue angioedema associated with an angiotensin-converting enzyme inhibitor. (15080211)
2004
28
Insulin resistance, inflammation, and the prediabetic state. (12957323)
2003
29
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
30
Rapid Ca2+-dependent decrease of protein ubiquitination at synapses. (14657369)
2003
31
The adjunctive value of routine biochemistry in nutritional assessment of hospitalized patients. (11883995)
2001
32
Differential effects of ethanol on signal transduction. (10656198)
2000
33
Cholecystokinin in acute alcoholic and biliary pancreatitis. (11185710)
2000
34
Early detection of undiagnosed diabetes mellitus: a US perspective. (10934451)
2000
35
Contribution of cholescintigraphy to the early diagnosis of acute acalculous cholecystitis in intensive-care-unit patients. (10541831)
1999
36
Leukodystrophy and bone marrow transplantation: role of mixed hematopoietic chimerism. (10227686)
1999
37
Neoadjuvant chemotherapy with accelerated CNF plus G-CSF in patients with breast cancer tumors larger than three centimeters: a pilot study. (9538146)
1998
38
Bilateral internal jugular venous thrombosis complicating severe ovarian hyperstimulation syndrome after prophylactic albumin administration. (9207607)
1997
39
A papulonecrotic eruption in a young man. Lymphomatoid papulosis. (9371032)
1997
40
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. (8601610)
1996
41
Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study. (8916080)
1996
42
Acute effects of a single administration of dexamethasone on basal and growth hormone-releasing hormone stimulated GH secretion in acromegaly. (8137516)
1994
43
Pseudomyxoma peritonei due to adenocarcinoma of the lung: case report. (8061804)
1994
44
Long-term results of long-acting luteinizing-hormone-releasing hormone agonist in central precocious puberty. (1840142)
1991
45
Antithrombin III Sudbury: an Ala384----Pro mutation with abnormal thrombin-binding activity and thrombotic diathesis. (2093312)
1990
46
The Hermansky-Pudlak syndrome. Report of three cases and review of pathophysiology and management considerations. (3921802)
1985
47
Heterogeneity of holocarboxylase synthetase in patients with biotin-responsive multiple carboxylase deficiency. (3920902)
1985
48
PEPTIC ESOPHAGITIS. ITS SURGICAL SIGNIFICANCE. (14229738)
1964
49
Relationship of nodular goiter to thyroid carcinoma; brief review with a note on the diagnostic role of needle biopsy. (15394618)
1949
50

Variations for Cystic Lymphangioma

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Expression for genes affiliated with Cystic Lymphangioma

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Search GEO for disease gene expression data for Cystic Lymphangioma.

Pathways for genes affiliated with Cystic Lymphangioma

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GO Terms for genes affiliated with Cystic Lymphangioma

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Biological processes related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1T cell receptor signaling pathwayGO:005085210.0IFNG, PIK3CA
2adaptive immune responseGO:00022509.9IFNG, PIK3CA
3vasculature developmentGO:00019449.8NODAL, PIK3CA
4SMAD protein signal transductionGO:00603959.7AFP, NODAL
5liver developmentGO:00018899.1AFP, NODAL, PIK3CA
6cation transmembrane transportGO:00986559.1CHRND, CHRNG
7synaptic transmission, cholinergicGO:00072718.7CHRND, CHRNG

Molecular functions related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular ligand-gated ion channel activityGO:00052309.0CHRND, CHRNG
2acetylcholine receptor activityGO:00154648.9CHRND, CHRNG

Sources for Cystic Lymphangioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet