MCID: CYS002
MIFTS: 56

Cystic Lymphangioma malady

Rare diseases, Cardiovascular diseases, Skin diseases, Fetal diseases, Cancer diseases, Immune diseases categories
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Summaries for Cystic Lymphangioma

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NIH Rare Diseases:42 Cystic hygroma is a birth defect that causes a soft mass, often in the head and neck area. it may be discovered in a fetus during a pregnancy ultrasound, in a newborn, or it may not become evident until later in life. when a cystic hygroma is identified in a fetus, parents are counseled regarding their baby's risk for having a chromosome problem or other birth defect, and are offered additional testing options such as special ultrasound tests or amniocentesis. cystic hygromas in infants, children, or adults may enlarge or become infected, and may require surgery or other therapy to remove or shrink the mass. last updated: 3/4/2010

MalaCards based summary: Cystic Lymphangioma, also known as cystic hygroma, is related to multiple pterygium syndrome lethal type and hepatitis. An important gene associated with Cystic Lymphangioma is CHRNG (cholinergic receptor, nicotinic, gamma (muscle)), and among its related pathways are Activation of Nicotinic Acetylcholine Receptors and Calcium channels. The compounds galantamine and acyclovir have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and colon, and related mouse phenotypes are tumorigenesis and vision/eye.

Description from OMIM:46 257350

Aliases & Classifications for Cystic Lymphangioma

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Sources:
8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 48Orphanet, 46OMIM, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet
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Cystic Lymphangioma, Aliases & Descriptions:

Name: Cystic Lymphangioma 8 10
Cystic Hygroma 8 42 48 46
 
Lymphangioma, Cystic 62


Classifications:



Characteristics (Orphanet epidemiological data):

48
cystic hygroma:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


External Ids:

Disease Ontology8 DOID:3081
NCIt39 C3724
MeSH34 D018191
OMIM46 257350
ICD10 via Orphanet26 D18.1

Related Diseases for Cystic Lymphangioma

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Graphical network of the top 20 diseases related to Cystic Lymphangioma:



Diseases related to cystic lymphangioma

Symptoms for Cystic Lymphangioma

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Clinical features from OMIM:

257350

Drugs & Therapeutics for Cystic Lymphangioma

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Drug clinical trials:

Search ClinicalTrials for Cystic Lymphangioma

Search NIH Clinical Center for Cystic Lymphangioma

Genetic Tests for Cystic Lymphangioma

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Anatomical Context for Cystic Lymphangioma

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MalaCards organs/tissues related to Cystic Lymphangioma:

32
Testes, Pancreas, Colon, Spleen, Breast, Adrenal gland, Skin, Tongue, Kidney, Heart, Liver, Lung, Thyroid, Testis

Animal Models for Cystic Lymphangioma or affiliated genes

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Publications for Cystic Lymphangioma

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Articles related to Cystic Lymphangioma:

(show top 50)    (show all 352)
idTitleAuthorsYear
1
Unusual sites of cystic lymphangioma in children. (25282458)
2014
2
Cystic lymphangioma of the inguinal and scrotal regions in childhood - report of three cases. (25125963)
2014
3
Pancreatic cystic lymphangioma: diagnostic approach with MDCT and MR imaging. (25073240)
2014
4
Pericardial cystic lymphangioma. (23034994)
2013
5
An unusual cause of abdominal pain: duodenal cystic lymphangioma. (23961273)
2013
6
Differentiating a large abdominal cystic lymphangioma from multicystic mesothelioma: report of a case. (23807639)
2013
7
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
8
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
9
Cystic fibrosis and retroperitoneal cystic lymphangioma: a novel match. (22273284)
2012
10
A case of laparoscopic excision of a huge retroperitoneal cystic lymphangioma. (22606623)
2011
11
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
12
Retroperitoneal cystic lymphangioma: a rare presentation in childhood, treated laparoscopically. (19215217)
2009
13
Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: Case presentation and review of the literature. (19851133)
2009
14
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
15
Lingual cystic lymphangioma in an elderly patient. (19052498)
2008
16
Cystic lymphangioma of the lesser sac presenting as acute appendicitis: A case report. (18783617)
2008
17
Cystic lymphangioma of the pancreas. (17368224)
2007
18
Cystic lymphangioma of the lesser sac. (16955953)
2006
19
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
20
Image of the month. Cystic lymphangioma. (16027339)
2005
21
Mesenteric cystic lymphangioma causing intestinal occlusion in an adult patient. (14722994)
2003
22
Asymptomatic adult cystic lymphangioma of the spleen: case report and review of the literature. (12620551)
2003
23
Antepartum assessment of fetal cystic lymphangioma by magnetic resonance imaging. (12186991)
2002
24
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
25
Giant cystic lymphangioma of the stomach. (11841086)
2001
26
Huge cystic lymphangioma of the pancreas: report of a case. (11510617)
2001
27
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
28
Cystic lymphangioma in an asymptomatic newborn: an uncommon localization in the ileum. (10204513)
1999
29
Bilateral cystic lymphangioma of the adrenal gland. (10219366)
1999
30
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
31
Progressive fetal axillary cystic lymphangioma with coexistent naevus flammeus. (9039304)
1997
32
Prenatal ultrasonographic findings of intra-abdominal cystic lymphangioma: a case report. (9142629)
1997
33
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
34
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
35
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
36
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
37
Intra-abdominal cystic lymphangioma. (7927442)
1994
38
Cystic lymphangioma of the kidney: a rare cause of multiloculated renal masses. (1999216)
1991
39
Abdominal cystic lymphangioma. A case report and a review of the literature. (2180901)
1990
40
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
41
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
42
Cystic lymphangioma of the colon. Report of a case and review of the literature. (6489077)
1984
43
Recurrent massive cystic lymphangioma. (114944)
1978
44
Solitary cystic lymphangioma of the retroperitoneum. (904040)
1977
45
Cystic lymphangioma of the cecum with ileocecal intussusception: Case report. (1163907)
1975
46
Case report: Cystic lymphangioma of the vallecula. (1131722)
1975
47
Symptomatic venous compression from a mediastinal cystic lymphangioma. (4574172)
1973
48
Cystic lymphangioma of the parotid region. (14417246)
1960
49
Ureteral obstruction due to retroperitoneal lymphatic cyst (cystic lymphangioma). (13655395)
1959
50
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914

Variations for Cystic Lymphangioma

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Expression for genes affiliated with Cystic Lymphangioma

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Expression patterns in normal tissues for genes affiliated with Cystic Lymphangioma

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Pathways for genes affiliated with Cystic Lymphangioma

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Pathways related to Cystic Lymphangioma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9CHRNG, CHRND
29.9CHRND, CHRNG
39.7AFP, IFNG
49.7TGFB1, PTCH1
5
Show member pathways
9.6IFNG, TGFB1
69.6IFNG, TGFB1
79.6IFNG, TGFB1
8
Show member pathways
9.6IFNG, TGFB1
9
Show member pathways
9.6IFNG, TGFB1
109.6IFNG, TGFB1
119.6IFNG, TGFB1
129.6IFNG, TGFB1
139.6TGFB1, IFNG
14
Show member pathways
IL27-mediated signaling events37
9.6IFNG, TGFB1
15
Show member pathways
9.4CHRNG, CHRND, TGFB1
16
Show member pathways
9.4CHRNG, CHRND, TGFB1

Compounds for genes affiliated with Cystic Lymphangioma

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Compounds related to Cystic Lymphangioma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1galantamine44 50 1112.2CHRNG, CHRND
2acyclovir44 1111.0IFNG, AFP
3con a4410.0IFNG, AFP
4tranilast449.9IFNG, TGFB1
5pirfenidone44 6110.9TGFB1, IFNG
6gm-csf44 2810.9IFNG, TGFB1
7anti-fungal449.9IFNG, AFP
8methylcellulose449.9TGFB1, IFNG
9ribavirin44 50 1111.8IFNG, AFP
10il 10449.8IFNG, TGFB1
114-hydroxytamoxifen449.7TGFB1, IFNG
12polyethylene glycol449.6TGFB1, AFP
13pdtc449.6IFNG, TGFB1
14bleomycin44 1110.5AFP, TGFB1
15butyrate449.5AFP, TGFB1, IFNG
16paraffin449.5AFP, PTCH1, TGFB1
17actinomycin d449.5IFNG, TGFB1, AFP
18carboplatin44 50 1111.4IFNG, DSCAM, AFP
19thalidomide44 50 61 1112.4IFNG, AFP
20thymidine44 2410.3IFNG, TGFB1, AFP
21paclitaxel44 50 1111.3AFP, TGFB1, DSCAM

GO Terms for genes affiliated with Cystic Lymphangioma

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Cellular components related to Cystic Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-gated channel complexGO:0058929.9CHRNG, CHRND

Biological processes related to Cystic Lymphangioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:0069369.9CHRNG, CHRND
2protein import into nucleus, translocationGO:0000609.8IFNG, TGFB1
3extrinsic apoptotic signaling pathwayGO:0971919.8IFNG, TGFB1
4regulation of membrane potentialGO:0423919.8CHRNG, CHRND
5negative regulation of epithelial cell proliferationGO:0506809.7TGFB1, PTCH1
6transportGO:0068109.6CHRNG, CHRND, AFP
7response to estradiolGO:0323559.4TGFB1, PTCH1
8response to drugGO:0424939.3PTCH1, TGFB1, IFNG

Molecular functions related to Cystic Lymphangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetylcholine-activated cation-selective channel activityGO:0048899.9CHRNG, CHRND

Products for genes affiliated with Cystic Lymphangioma

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Sources for Cystic Lymphangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet