MCID: CYS002
MIFTS: 43

Cystic Lymphangioma malady

Categories: Rare diseases, Cardiovascular diseases, Skin diseases, Fetal diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Cystic Lymphangioma

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Aliases & Descriptions for Cystic Lymphangioma:

Name: Cystic Lymphangioma 10 12
Cystic Hygroma 10 45 51
 
Lymphangioma, Cystic 36 65

Characteristics:

Orphanet epidemiological data:

51
cystic hygroma:
Inheritance: Not applicable; Age of onset: Infancy,Neonatal

Classifications:



External Ids:

Disease Ontology10 DOID:3081
MeSH36 D018191
NCIt42 C3724
Orphanet51 79486
ICD10 via Orphanet28 D18.1
UMLS65 C0206620

Summaries for Cystic Lymphangioma

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NIH Rare Diseases:45 Cystic hygroma (meaning “moist tumor”) are fluid-filled sacs that result from a blockage in the lymphatic system, often in the head and neck area. a cystic hygroma may be discovered in a fetus during a pregnancy ultrasound, present as a birth defect (congenital) in a newborn, or it may not become evident until later in life. the causes include environmental factors, genetic factors, or unknown factors. the majority of prenatally diagnosed cystic hygromas are due to a chromosomal abnormality known as turner syndrome, in which a female has only one x chromosome instead of two. when a cystic hygroma is identified in a fetus, parents are counseled regarding their baby's risk for having a chromosome problem or other birth defect, and are offered additional testing options such as special ultrasound tests or amniocentesis. cystic hygromas can occur as an isolated finding or with other birth defect as part of a syndrome. isolated cystic hygroma may be inherited as an autosomal recessive disorder. a fetal cystic hygroma may progress to hydrops (an excess amount of fluid in the body) and eventually to fetal death. cystic hygromas in infants, children, or adults may enlarge or become infected, and may require surgery or other therapy to remove or shrink the mass. fetal cystic hygroma may be treated with serial thoracocentesis plus paracentesis. last updated: 2/26/2016

MalaCards based summary: Cystic Lymphangioma, also known as cystic hygroma, is related to fetal cystic hygroma and abdominal cystic lymphangioma, and has symptoms including pain of lymph node An important gene associated with Cystic Lymphangioma is IFNG (Interferon, Gamma), and among its related pathways are PDGFR-alpha signaling pathway and Glucocorticoid receptor regulatory network. Affiliated tissues include testes, pancreas and breast, and related mouse phenotype muscle.

Related Diseases for Cystic Lymphangioma

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Graphical network of the top 20 diseases related to Cystic Lymphangioma:



Diseases related to cystic lymphangioma

Symptoms for Cystic Lymphangioma

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UMLS symptoms related to Cystic Lymphangioma:


pain of lymph node

Drugs & Therapeutics for Cystic Lymphangioma

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Drugs for Cystic Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1PicibanilPhase 2, Phase 37
2
PancrelipaseapprovedPhase 088053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
3pancreatinPhase 0880

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic MalformationsCompletedNCT00010452Phase 2, Phase 3
2AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)RecruitingNCT02250456
3Needle-based Confocal Laser Endomicroscopy on Pancreatic Cystic LesionsRecruitingNCT02494388Phase 0

Search NIH Clinical Center for Cystic Lymphangioma


Cochrane evidence based reviews: lymphangioma, cystic

Genetic Tests for Cystic Lymphangioma

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Anatomical Context for Cystic Lymphangioma

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MalaCards organs/tissues related to Cystic Lymphangioma:

33
Testes, Pancreas, Breast, T cells, Liver, Thyroid, Lung

Animal Models for Cystic Lymphangioma or affiliated genes

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MGI Mouse Phenotypes related to Cystic Lymphangioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2CHRNG, DOK7, IFNG, NODAL, PIK3CA

Publications for Cystic Lymphangioma

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Articles related to Cystic Lymphangioma:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Giant cystic lymphangioma originating from the cardia of the stomach: A case report. (27168832)
2016
2
Cystic Lymphangioma of Pancreas. (27065694)
2016
3
Case Report: Multivisceral Transplantation for an Extensive Cystic Lymphangioma of the Mesenteric Root. (27109997)
2016
4
A sudden pain in the neck: an atypical presentation of cystic lymphangioma. (25795753)
2015
5
Cystic lymphangioma of the chest wall: a case report. (25606029)
2014
6
Unusual sites of cystic lymphangioma in children. (25282458)
2014
7
Cystic lymphangioma of the inguinal and scrotal regions in childhood - report of three cases. (25125963)
2014
8
Pancreatic cystic lymphangioma: diagnostic approach with MDCT and MR imaging. (25073240)
2014
9
Pericardial cystic lymphangioma. (23034994)
2013
10
An unusual cause of abdominal pain: duodenal cystic lymphangioma. (23961273)
2013
11
Intestinal obstruction complicating a mesenteric cystic lymphangioma. (22795361)
2012
12
Huge cystic lymphangioma of the pancreas mimicking pancreatic cystic neoplasm. (23197988)
2012
13
Cystic fibrosis and retroperitoneal cystic lymphangioma: a novel match. (22273284)
2012
14
A case of laparoscopic excision of a huge retroperitoneal cystic lymphangioma. (22606623)
2011
15
Cystic lymphangioma of the breast in a 6-year-old boy. (19853765)
2009
16
Retroperitoneal cystic lymphangioma: a rare presentation in childhood, treated laparoscopically. (19215217)
2009
17
Cystic lymphangioma-like adenomatoid tumor of the adrenal gland: Case presentation and review of the literature. (19851133)
2009
18
Cystic lymphangioma of the gallbladder: report of a case. (18085372)
2008
19
Lingual cystic lymphangioma in an elderly patient. (19052498)
2008
20
Cystic lymphangioma of the lesser sac presenting as acute appendicitis: A case report. (18783617)
2008
21
Cystic lymphangioma of the pancreas. (17368224)
2007
22
Cystic lymphangioma of the lesser sac. (16955953)
2006
23
Prenatal diagnosis of a fetal chest wall cystic lymphangioma using ultrasonography and MRI: a case report with literature review. (16260884)
2005
24
Image of the month. Cystic lymphangioma. (16027339)
2005
25
Mesenteric cystic lymphangioma causing intestinal occlusion in an adult patient. (14722994)
2003
26
Antepartum assessment of fetal cystic lymphangioma by magnetic resonance imaging. (12186991)
2002
27
Abdominal cystic lymphangioma: a rare cause of acute abdomen in a neonate. (11737721)
2001
28
Giant cystic lymphangioma of the stomach. (11841086)
2001
29
Huge cystic lymphangioma of the pancreas: report of a case. (11510617)
2001
30
Abdominal cystic lymphangioma in a woman at 14 weeks' gestation: case report. (11055491)
2000
31
Cystic lymphangioma in an asymptomatic newborn: an uncommon localization in the ileum. (10204513)
1999
32
Mediastinal cystic lymphangioma: report of two cases. (9323827)
1997
33
Progressive fetal axillary cystic lymphangioma with coexistent naevus flammeus. (9039304)
1997
34
Prenatal ultrasonographic findings of intra-abdominal cystic lymphangioma: a case report. (9142629)
1997
35
Radiology/pathology conference: mesenteric cystic lymphangioma. (8692443)
1996
36
Abdominal cystic lymphangioma in children: benign lesions that can have a proliferative course. (8861480)
1996
37
Cystic lymphangioma of the transverse colon: report of a case and review of the literature. (8832861)
1996
38
Laparoscopic resection of a retroperitoneal cystic lymphangioma. (7878511)
1994
39
Intra-abdominal cystic lymphangioma. (7927442)
1994
40
Cystic lymphangioma of the kidney: a rare cause of multiloculated renal masses. (1999216)
1991
41
Abdominal cystic lymphangioma. A case report and a review of the literature. (2180901)
1990
42
Hyponatremia resulting from loss of lymphatic fluid in an infant with cystic lymphangioma. (3723245)
1986
43
Sonographic appearance of an abdominal cystic lymphangioma. (6699930)
1984
44
Solitary cystic lymphangioma of the retroperitoneum. (904040)
1977
45
Cystic lymphangioma of the cecum with ileocecal intussusception: Case report. (1163907)
1975
46
Case report: Cystic lymphangioma of the vallecula. (1131722)
1975
47
Symptomatic venous compression from a mediastinal cystic lymphangioma. (4574172)
1973
48
Cystic lymphangioma of the parotid region. (14417246)
1960
49
CYSTIC LYMPHANGIOMA OF THE GREAT OMENTUM. (17863276)
1914
50

Variations for Cystic Lymphangioma

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Expression for genes affiliated with Cystic Lymphangioma

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Search GEO for disease gene expression data for Cystic Lymphangioma.

Pathways for genes affiliated with Cystic Lymphangioma

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GO Terms for genes affiliated with Cystic Lymphangioma

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Biological processes related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1T cell receptor signaling pathwayGO:005085210.0IFNG, PIK3CA
2adaptive immune responseGO:00022509.9IFNG, PIK3CA
3vasculature developmentGO:00019449.8NODAL, PIK3CA
4SMAD protein signal transductionGO:00603959.7AFP, NODAL
5liver developmentGO:00018899.1AFP, NODAL, PIK3CA
6cation transmembrane transportGO:00986559.1CHRND, CHRNG
7synaptic transmission, cholinergicGO:00072718.7CHRND, CHRNG

Molecular functions related to Cystic Lymphangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular ligand-gated ion channel activityGO:00052309.0CHRND, CHRNG
2acetylcholine receptor activityGO:00154648.9CHRND, CHRNG

Sources for Cystic Lymphangioma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet