MCID: CYS007
MIFTS: 35

Cystic Nephroma malady

Categories: Nephrological diseases, Cancer diseases

Aliases & Classifications for Cystic Nephroma

Aliases & Descriptions for Cystic Nephroma:

Name: Cystic Nephroma 12 14
Benign Cystic Nephroma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2673

Summaries for Cystic Nephroma

MalaCards based summary : Cystic Nephroma, also known as benign cystic nephroma, is related to mesenchymoma and malignant cystic nephroma. An important gene associated with Cystic Nephroma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are B Cell Development Pathways and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Fentanyl and pancreatic polypeptide have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

Related Diseases for Cystic Nephroma

Diseases in the Cystic Nephroma family:

Malignant Cystic Nephroma

Diseases related to Cystic Nephroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
id Related Disease Score Top Affiliating Genes
1 mesenchymoma 29.5 KIT PGR VIM
2 malignant cystic nephroma 12.1
3 pleuropulmonary blastoma 11.5
4 mixed epithelial stromal tumour 11.1
5 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.0
6 central nervous system tuberculosis 10.2 MME PGR
7 nipple neoplasm 10.2 DICER1 PGR
8 papilloma 10.2 MME PGR
9 panophthalmitis 10.2 MME PGR
10 vaginal adenosarcoma 10.2 MME PGR
11 bone deterioration disease 10.2 DES DICER1
12 small intestinal vasoactive intestinal peptide producing tumor 10.2 DES MME
13 bile duct rhabdomyosarcoma 10.2 DES MME
14 exudative glomerulonephritis 10.2 DES DICER1
15 paranasal sinus cancer 10.2 KIT MME
16 male reproductive organ benign neoplasm 10.2 MME PGR
17 central nervous system primitive neuroectodermal neoplasm 10.2 MME PGR
18 atypical lipomatous tumor 10.2 KIT PGR
19 sphenoid sinus squamous cell carcinoma 10.2 KIT MME
20 handigodu disease 10.2 DICER1 VIM
21 trachea sarcoma 10.2 MME PGR
22 skin angiosarcoma 10.2 KIT PGR
23 intestinal neuroendocrine benign tumor 10.2 KIT PGR
24 vulva basal cell carcinoma 10.2 KIT PGR
25 blastoma 10.2
26 middle ear adenocarcinoma 10.2 KIT PGR
27 biliary tract neoplasm 10.2 DICER1 PGR
28 t-cell adult acute lymphocytic leukemia 10.2 MME PGR
29 lung clear cell carcinoma 10.2 MME PGR
30 carbon monoxide-induced parkinsonism 10.2 DES KIT
31 factitious disorder 10.2 KIT MME
32 testis sarcoma 10.2 DES KIT
33 ovarian embryonal carcinoma 10.2 KIT PGR
34 postpartum depression 10.2 KIT PGR
35 cranial nerve disease 10.1 KIT MME
36 vulva adenocarcinoma 10.1 MME PGR
37 retinal vein occlusion 10.1 KIT MME
38 lymphangiosarcoma 10.1 MME VIM
39 struma ovarii 10.1 MME PGR
40 pustulosis palmaris et plantaris 10.1 DES KIT
41 endometrial stromal sarcoma 10.1 PGR VIM
42 bladder adenocarcinoma 10.1 PGR VIM
43 reactive arthritis 10.1 KIT PGR
44 13q12.3 microdeletion syndrome 10.1 DES VIM
45 breast duct papilloma 10.1 MME PGR
46 mucinous tubular and spindle renal cell carcinoma 10.1 MME VIM
47 inflammatory linear verrucous epidermal nevus 10.1 DES VIM
48 intracranial sinus thrombosis 10.1 KIT VIM
49 osteomyelitis 10.1 DES VIM
50 myoma 10.1 DES VIM

Graphical network of the top 20 diseases related to Cystic Nephroma:



Diseases related to Cystic Nephroma

Symptoms & Phenotypes for Cystic Nephroma

GenomeRNAi Phenotypes related to Cystic Nephroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 WT1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.78 KIT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.78 VIM
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.78 WT1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.78 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 KIT WT1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.78 KIT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.78 KIT
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.78 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.78 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.78 VIM
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 WT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.78 WT1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.78 KIT VIM WT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.78 WT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.78 KIT
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 WT1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.78 WT1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 KIT VIM WT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.78 KIT
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.78 KIT

MGI Mouse Phenotypes related to Cystic Nephroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 DES DICER1 KIT PGR VIM WT1
2 cellular MP:0005384 9.88 DES DICER1 KIT PGR VIM WT1
3 homeostasis/metabolism MP:0005376 9.87 DES DICER1 KIT MME PGR VIM
4 embryo MP:0005380 9.77 DICER1 KIT PGR VIM WT1
5 immune system MP:0005387 9.73 WT1 DICER1 KIT MME PGR VIM
6 muscle MP:0005369 9.55 DES KIT PGR VIM WT1
7 neoplasm MP:0002006 9.26 DICER1 KIT PGR WT1
8 reproductive system MP:0005389 9.02 DICER1 KIT PGR VIM WT1

Drugs & Therapeutics for Cystic Nephroma

Drugs for Cystic Nephroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 pancreatic polypeptide Phase 3
3 Analgesics Phase 3
4 Adjuvants, Anesthesia Phase 3
5 Narcotics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Liver Extracts Phase 3,Phase 1,Phase 2
12 Central Nervous System Depressants Phase 3
13 Cola Nutraceutical Phase 3
14
Etoposide Approved Phase 1, Phase 2 33419-42-0 36462
15
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
16
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
17
Ifosfamide Approved Phase 1, Phase 2 3778-73-2 3690
18
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
19 Alkylating Agents Phase 1, Phase 2
20 Topoisomerase Inhibitors Phase 1, Phase 2
21 Etoposide phosphate Phase 1, Phase 2
22 Protein Kinase Inhibitors Phase 1, Phase 2
23 Isophosphamide mustard Phase 1, Phase 2
24 Antineoplastic Agents, Alkylating Phase 1, Phase 2
25 Antineoplastic Agents, Phytogenic Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
2 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
5 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Cystic Nephroma

Genetic Tests for Cystic Nephroma

Anatomical Context for Cystic Nephroma

MalaCards organs/tissues related to Cystic Nephroma:

39
Kidney, Lung

Publications for Cystic Nephroma

Articles related to Cystic Nephroma:

(show top 50) (show all 132)
id Title Authors Year
1
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree. ( 28222777 )
2017
2
Tumor Progression in DICER1-mutated Cystic Nephroma - witnessing the genesis of Anaplastic Sarcoma of the Kidney. ( 27036314 )
2016
3
Cystic Nephroma in Adults: A Clinicopathologic Study of 46 Cases. ( 27831959 )
2016
4
Pediatric cystic nephromas: distinctive features and frequent DICER1 mutations. ( 26772403 )
2016
5
Multilocular Cystic Renal Cell Carcinoma or Cystic Nephroma? ( 28074169 )
2016
6
Cystic nephroma of the kidney. ( 25444959 )
2015
7
An Unusual Presentation of Cystic Nephroma in an Adult Man. ( 26266015 )
2015
8
Multilocular Cystic Nephroma: A Systematic Literature Review of the Radiologic and Clinical Findings. ( 26587924 )
2015
9
A rare case of bilateral cystic nephroma associated with embryonal rhabdomyosarcoma of the penile urethra. ( 25829672 )
2015
10
Multilocular cystic nephroma: A clinical case. ( 24892395 )
2014
11
Uretheral invagination of multilocular cystic nephroma; a case report of a new pathologic variant. ( 25197409 )
2014
12
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. ( 24481001 )
2014
13
Multilocular cystic nephroma treated with laparoscopic nephron-sparing surgery: A case report. ( 25210560 )
2014
14
Laparoscopic Partial Nephrectomy for the Treatment of Large Cystic Nephroma in Children. ( 25265482 )
2014
15
Quiz page JULY 2014: bilateral abdominal masses in an infant. Diagnosis: Bilateral cystic nephroma. ( 24954459 )
2014
16
Cystic Nephroma/Mixed Epithelial Stromal Tumor: A Benign Neoplasm With Potential for Recurrence. ( 25525149 )
2014
17
Renal metastasis of an ovarian granulosa cell tumour inducing growth of a cystic nephroma. ( 23843415 )
2013
18
Case report: Multimodality imaging of a cystic nephroma. ( 23861515 )
2013
19
Adult multilocular cystic nephroma: Report of six cases with clinical, radio-pathologic correlation and review of literature. ( 23662002 )
2013
20
Coexistence of cystic nephroma and neuroblastoma: a rare case of a childhood collision tumor. ( 22395847 )
2012
21
Asymptomatic infantile cystic nephroma: a diagnostic dilemma. ( 24293912 )
2012
22
Can multilocular cystic nephroma be a harbinger of multilocular cystic renal cell carcinoma? ( 23032854 )
2012
23
Bilateral cystic nephroma with pleuropulmonary blastoma. ( 22688934 )
2011
24
Cystic nephroma: a diagnostic dilemma. ( 20427881 )
2010
25
Germline DICER1 mutations and familial cystic nephroma. ( 21036787 )
2010
26
What is a cystic nephroma? ( 20035151 )
2010
27
Cystic nephroma masquerading as hydatid cyst of the kidney. ( 21045463 )
2010
28
Cystic nephroma: a fine needle aspiration diagnostic pitfall. ( 20391987 )
2010
29
Bilateral progressive cystic nephroma in a 9-month-old male infant requiring renal replacement therapy. ( 20414683 )
2010
30
Cystic nephroma in childhood. ( 19661676 )
2009
31
Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. ( 19172100 )
2009
32
Re: Rodolfo Montironi, Roberta Mazzuccelli, Antonio Lopez-Beltran, et al. Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? Eur Urol 2008;54:1237-46. ( 19167806 )
2009
33
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. ( 18971776 )
2009
34
Adult cystic nephroma: a case report and a review of the literature. ( 18555707 )
2009
35
Multilocular cystic nephroma and multicystic clear cell carcinoma: two faces of the Roman god Janus? ( 18611925 )
2009
36
[Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. ( 19781188 )
2009
37
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. ( 18313107 )
2008
38
Cytology of cystic nephroma: a case report. ( 18323282 )
2008
39
Failure of percutaneous endoscopic resection of a renal cystic nephroma on longer-term follow-up. ( 18613780 )
2008
40
Sonographic diagnosis of an unusual case of multilocular cystic nephroma mimicking polycystic kidney disease. ( 19034827 )
2008
41
Editorial comment on: cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? ( 18006142 )
2008
42
Cystic nephroma: a case report and review of the literature. ( 18947428 )
2008
43
Cystic nephroma and localized renal cystic disease in children: diagnostic clues and management. ( 18970929 )
2008
44
Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? ( 18006141 )
2008
45
Multilocular cystic nephroma of the kidney. ( 19008600 )
2008
46
Best cases from the AFIP: Multilocular cystic renal tumor: cystic nephroma. ( 18635639 )
2008
47
Pleuropulmonary blastema with cystic nephroma - A rare presentation and surgical dilemma. ( 19057859 )
2008
48
Cystic nephroma: report of a case and review of the literature. ( 18019431 )
2007
49
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. ( 23132986 )
2007
50
Familial multilocular cystic nephroma: a variant of a unique renal neoplasm. ( 17656243 )
2007

Variations for Cystic Nephroma

Expression for Cystic Nephroma

Search GEO for disease gene expression data for Cystic Nephroma.

Pathways for Cystic Nephroma

Pathways related to Cystic Nephroma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.88 KIT MME
2 10.67 MME VIM WT1
3
Show member pathways
10.61 DES VIM

GO Terms for Cystic Nephroma

Cellular components related to Cystic Nephroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 DES DICER1 KIT MME PGR VIM

Biological processes related to Cystic Nephroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.96 DES VIM
2 intermediate filament organization GO:0045109 8.62 DES VIM

Molecular functions related to Cystic Nephroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 8.62 DICER1 VIM

Sources for Cystic Nephroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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