MCID: CYS007
MIFTS: 38

Cystic Nephroma malady

Nephrological category

Summaries for Cystic Nephroma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

MalaCards: Cystic Nephroma, also known as benign cystic nephroma, is related to wilms tumor and adenoma. An important gene associated with Cystic Nephroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Keratin filaments. The compounds dexamethasone and glycogen have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung, and related mouse phenotypes are homeostasis/metabolism and muscle.

Aliases & Classifications for Cystic Nephroma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

cystic nephroma 8 10
benign cystic nephroma 61


External Ids:

Disease Ontology8 DOID:2673

Related Diseases for Cystic Nephroma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cystic Nephroma family:

malignant cystic nephroma

Diseases related to Cystic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.5VIM, WT1, DES, MME, KRT7, ACTC1
2adenoma30.1MUC1, KRT19, KRT7, ACTC1
3angiomyolipoma30.1ACTC1, PGR, VIM, DES
4pleuropulmonary blastoma10.6
5blastoma10.5
6mixed epithelial stromal tumour10.5
7malignant cystic nephroma10.5
8multilocular cystic renal cell carcinoma10.4
9childhood multilocular cystic kidney neoplasm10.1
10polycystic kidney disease10.1
11pulmonary sequestration10.1
12hemangioma10.0ACTC1
13infantile myofibromatosis10.0DES
14papilloma10.0ACTC1
15lipoma10.0DES
16fasciitis10.0ACTC1
17nephroblastoma10.0WT1
18congestive heart failure10.0MME
19bladder carcinoma10.0KRT19
20glomerulonephritis10.0MME
21benign mesothelioma10.0WT1
22ductal carcinoma in situ10.0PGR
23thyroid cancer10.0KRT19
24synovial sarcoma10.0KRT7
25leiomyomatosis10.0PGR
26renal oncocytoma10.0KRT7
27mixed cell type cancer10.0KRT7
28desmoid tumor10.0DES, ACTC1
29benign meningioma10.0PGR
30cystadenocarcinoma10.0MUC1
31hemangioblastoma10.0MUC1
32medulloblastoma10.0ACTC1, DES
33acute leukemia10.0WT1
34nephrogenic adenoma10.0KRT7
35uterine sarcoma10.0MME, DES
36fibrous meningioma10.0MUC1
37cutaneous fibrous histiocytoma10.0ACTC1, DES
38pseudomyxoma peritonei10.0KRT7
39oxyphilic adenoma10.0KRT7
40stomach cancer10.0KRT19
41endometriosis10.0ACTC1, PGR
42teratoma10.0ACTC1, KRT7
43myopathy10.0DES
44cystadenoma10.0MME, KRT7
45hidradenoma10.0MUC1
46lymphangioleiomyomatosis10.0DES, PGR
47leukemia10.0MME, WT1
48metanephric adenoma10.0WT1, KRT7
49alveolar rhabdomyosarcoma10.0WT1, DES
50myoma10.0PGR, DES

Graphical network of the top 20 diseases related to Cystic Nephroma:



Diseases related to cystic nephroma

Clinical Features for Cystic Nephroma

Drugs & Therapeutics for Cystic Nephroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cystic Nephroma

Drug clinical trials:

Search ClinicalTrials for Cystic Nephroma

Search NIH Clinical Center for Cystic Nephroma

Search CenterWatch for Cystic Nephroma

Genetic Tests for Cystic Nephroma

Anatomical Context for Cystic Nephroma

Sources:
33MalaCards
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MalaCards organs/tissues related to Cystic Nephroma:

33
Kidney, Lung

Animal Models for Cystic Nephroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cystic Nephroma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9DICER1, DES, PGR, ACTC1
2MP:00053698.1VIM, WT1, MEST, DES, PGR, ACTC1
3MP:00053807.3VIM, WT1, DICER1, MEST, PGR, KRT19
4MP:00028737.2WT1, DICER1, MUC1, PGR, KRT19, ACTC1
5MP:00053856.9ACTC1, VIM, WT1, DICER1, MEST, DES
6MP:00107686.8WT1, DICER1, MEST, DES, PGR, KRT19
7MP:00053846.7VIM, WT1, DICER1, MEST, PGR, KRT19

Publications for Cystic Nephroma

Sources:
51PubMed
See all sources

Articles related to Cystic Nephroma:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Case report: Multimodality imaging of a cystic nephroma. (23861515)
2013
2
Bilateral cystic nephroma with pleuropulmonary blastoma. (22688934)
2011
3
Cystic nephroma: a diagnostic dilemma. (20427881)
2010
4
What is a cystic nephroma? (20035151)
2010
5
Germline DICER1 mutations and familial cystic nephroma. (21036787)
2010
6
Cystic nephroma: a fine needle aspiration diagnostic pitfall. (20391987)
2010
7
Cystic nephroma in childhood. (19661676)
2009
8
Adult cystic nephroma: a case report and a review of the literature. (18555707)
2009
9
Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. (19781188)
2009
10
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence. (18971776)
2009
11
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. (18313107)
2008
12
Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? (18006141)
2008
13
Cystic nephroma: a case report and review of the literature. (18947428)
2008
14
Sonographic diagnosis of an unusual case of multilocular cystic nephroma mimicking polycystic kidney disease. (19034827)
2008
15
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. (23132986)
2007
16
Cystic nephroma in the adult: pathological aspects and therapeutic implications. (18416340)
2007
17
Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. (17098684)
2006
18
Cystic renal cell carcinoma arising from multilocular cystic nephroma of the same kidney. (16650296)
2006
19
Mixed epithelial and stromal tumor of the kidney and cystic nephroma share overlapping features: reappraisal of 15 lesions. (16390243)
2006
20
Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity? (16546041)
2006
21
Percutaneous treatment of renal cystic nephroma. (16053364)
2005
22
A complicated case of bilateral cystic nephroma in a 16-month-old boy. (16273373)
2005
23
Multilocular cystic nephroma in adults. (15185822)
2004
24
Local recurrence of a unilateral cystic nephroma. (15147551)
2004
25
Best cases from the AFIP: cystic nephroma. (15026602)
2004
26
Benign multilocular cystic nephroma. (12921324)
2003
27
Cystic nephroma: a rare clinical entity. (12549633)
2002
28
Cystic nephroma: an unusual renal lesion. (10799201)
2000
29
Cystic nephroma--a case report and review of literature. (10063304)
1998
30
Quiz case of the month. Multilocular cystic nephroma (MLCN). (9221171)
1997
31
Dedifferentiated cystic nephroma with malignant mesenchymoma as the dedifferentiated component. (9025898)
1996
32
Solitary multilocular cyst of kidney (cystic nephroma). (7558107)
1995
33
Multilocular renal cyst (cystic nephroma) with mA1llerian-like stroma. (8154082)
1994
34
Partial nephrectomy in a metachronous multilocular cyst of the kidney (cystic nephroma). (8158788)
1994
35
Familial cystic nephroma and pleuropulmonary blastoma. (8280234)
1993
36
A case of multilocular cystic nephroma. (8381991)
1993
37
Cystic nephroma: cytologic findings in fine-needle aspiration cytology. (1334828)
1992
38
Cystic nephroma--an unusual cystic renal lesion. (1344162)
1992
39
Multilocular cystic nephroma. (2162227)
1990
40
Multilocular cyst (multilocular cystic nephroma) of the kidney: a report of 2 cases with an unusual mode of presentation. (2545928)
1989
41
Cystic nephroma: an emerging entity. (2557790)
1989
42
Actual approach to cystic nephroma. (2844542)
1988
43
Multilocular cystic nephroma: report of three cases. (3028697)
1987
44
Multilocular cystic nephroma simulating Wilms' tumour. (2825277)
1987
45
Cystic nephroma in children. Report of a case. (3006308)
1986
46
Case of the month. Benign multilocular cystic nephroma. (6313957)
1983
47
Cystic mesoblastic nephroma. (6277070)
1982
48
Congenital cystic mesoblastic nephroma. (7319492)
1981
49
Computed tomography of multilocular cystic nephroma. (7244215)
1981
50
Cystic nephroma. (199349)
1977

Genetic Variations for Cystic Nephroma

Expression for genes affiliated with Cystic Nephroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Nephroma

Search GEO for disease gene expression data for Cystic Nephroma.

Pathways for genes affiliated with Cystic Nephroma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Cystic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4ACTC1, DES, VIM
28.6VIM, KRT19, KRT7
38.0ACTC1, KRT7, KRT19, DES, VIM

Compounds for genes affiliated with Cystic Nephroma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Cystic Nephroma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1dexamethasone45 50 29 1113.5MME
2glycogen45 2411.1ACTC1, KRT7
3vitamin a45 11 2412.0MME, VIM
4eosin459.8VIM, MUC1
5orcein459.8ACTC1, DES, VIM
62-methoxyethanol459.7ACTC1, VIM
7toluene diisocyanate459.6MME, KRT19
8toluidine459.6DES, VIM
9oxygen45 2410.5MME, MUC1, DES
10imatinib45 50 1111.5ACTC1, DES, WT1
11cytarabine45 50 1111.4MME, MUC1, VIM
12dihydrotestosterone45 29 11 2412.4PGR, DES, VIM
13carbohydrates459.4KRT19
14s 100459.3VIM, DES, MUC1, ACTC1
15biotin45 11 2411.3ACTC1, MUC1, DES, VIM
16actinomycin d459.1VIM, DES, MUC1, MME
17lysine459.0VIM, WT1, DES, MME
18forskolin45 50 1111.0MME, MUC1, WT1, VIM
19cyclosporin a45 29 6011.0WT1, PGR, MME, ACTC1
20progestin459.0VIM, DES, MUC1, PGR
21bromodeoxyuridine458.9VIM, DES, MME, KRT19
2212-o-tetradecanoylphorbol 13-acetate458.9VIM, WT1, DES, MUC1, MME
23reticulin458.8VIM, DES, MUC1, KRT7, ACTC1
24mucicarmine458.8VIM, DES, MUC1, KRT7, ACTC1
25glucose458.7MUC1, KRT19, KRT7, ACTC1
26doxorubicin45 50 1110.7VIM, WT1, DES, PGR, MME
27arginine458.7KRT7, MME, DES, WT1, VIM
28methotrexate45 50 1110.7VIM, MUC1, PGR, KRT7
29thymidine45 249.5WT1, DES, MUC1, MME, KRT19
30lactate458.5VIM, DES, MME, KRT19
31iron45 249.4VIM, DES, KRT19, KRT7, ACTC1
32hyaluronic acid45 249.4VIM, WT1, DES, MUC1, KRT19
33retinoid458.3KRT7, KRT19, PGR, VIM
34cysteine458.2VIM, WT1, DES, MUC1, PGR, MME
35estradiol45 11 2410.1KRT19, PGR, MUC1, DES, VIM
36steroid458.1WT1, DES, PGR, MME, KRT19, ACTC1
37hematoxylin458.0VIM, DES, MUC1, KRT19, KRT7, ACTC1
38formaldehyde45 249.0VIM, DES, MUC1, KRT19, KRT7, ACTC1
39ribonucleic acid458.0WT1, MUC1, PGR, MME, KRT19, ACTC1
40matrigel458.0VIM, MUC1, MME, KRT19, KRT7, ACTC1
41adriamycin457.9VIM, DES, MUC1, PGR, MME, KRT19
42serine457.8VIM, WT1, DES, MUC1, MME, KRT19
43creatinine457.8VIM, WT1, DES, MUC1, MME, KRT19
44tyrosine457.7WT1, DES, MUC1, MME, KRT19, KRT7
45b 723457.6ACTC1, VIM, WT1, DES, MUC1, KRT19
46paraffin456.7VIM, WT1, DES, MUC1, PGR, MME
47progesterone45 60 29 11 2410.7VIM, WT1, DES, MUC1, PGR, MME
48testosterone45 60 11 249.7VIM, WT1, DES, MUC1, PGR, MME
49vegf456.7VIM, WT1, DES, MUC1, PGR, MME
50retinoic acid45 247.6VIM, WT1, DES, MUC1, PGR, MME

GO Terms for genes affiliated with Cystic Nephroma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.3KRT7, KRT19, DES, VIM

Biological processes related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.4ACTC1, DES, VIM

Molecular functions related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052008.5KRT19, DES, VIM
2protein bindingGO:0055156.1WT1, DICER1, DES, MUC1, PGR, MME

Products for genes affiliated with Cystic Nephroma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Cystic Nephroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet