MCID: CYS007
MIFTS: 45

Cystic Nephroma malady

Cancer diseases, Nephrological diseases categories
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Summaries for Cystic Nephroma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

MalaCards: Cystic Nephroma, also known as benign cystic nephroma, is related to wilms tumor and adenoma. An important gene associated with Cystic Nephroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Aurora B signaling and Striated Muscle Contraction. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Cystic Nephroma

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8Disease Ontology, 10DISEASES, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

cystic nephroma 8 10
benign cystic nephroma 62


External Ids:

Disease Ontology8 DOID:2673

Related Diseases for Cystic Nephroma

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17GeneCards, 18GeneDecks
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Diseases in the Cystic Nephroma family:

Malignant Cystic Nephroma

Diseases related to Cystic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.4DES, VIM, MME, ACTC1, KRT7, WT1
2adenoma30.1MUC1, ACTC1, KRT7, KRT19
3angiomyolipoma30.1DES, PGR, VIM, ACTC1
4pleuropulmonary blastoma10.6
5blastoma10.5
6malignant cystic nephroma10.4
7nephroblastoma10.4
8renal cell carcinoma10.4
9multilocular cystic renal cell carcinoma10.4
10mixed epithelial stromal tumour10.3
11infantile myofibromatosis10.1DES
12childhood multilocular cystic kidney neoplasm10.1
13polycystic kidney disease10.1
14kidney disease10.1
15malignant mesenchymoma10.1
16mesenchymoma10.1
17neuroblastoma10.1
18pulmonary sequestration10.1
19fasciitis10.1ACTC1
20kidney cancer10.1KRT7
21cystadenocarcinoma10.1MUC1
22nephrogenic adenoma10.1KRT7
23fibrous meningioma10.1MUC1
24hidradenoma10.1MUC1
25pseudomyxoma peritonei10.1KRT7
26leiomyomatosis10.1PGR
27desmoid tumor10.1DES, ACTC1
28ductal carcinoma in situ10.1PGR
29cutaneous fibrous histiocytoma10.1DES, ACTC1
30synovial sarcoma10.1KRT7
31uterine sarcoma10.1DES, MME
32hemangioma10.1ACTC1
33cystadenoma10.1KRT7, MME
34metanephric adenoma10.1KRT7, WT1
35mucinous cystadenocarcinoma10.1MUC1, KRT7
36cutaneous paget's disease10.1MUC1, KRT7
37thymus cancer10.1MUC1, KRT7
38alveolar rhabdomyosarcoma10.1WT1, DES
39ovarian brenner tumor10.1KRT7, WT1
40lymphangioleiomyomatosis10.1DES, PGR
41syringoma10.1MUC1, KRT19
42dysgerminoma10.0WT1, KRT7
43bile duct adenoma10.0KRT7, KRT19
44cervical adenocarcinoma10.0PGR, KRT7
45breast fibroadenoma10.0MME, PGR
46bowen syndrome10.0KRT7, KRT19
47embryonal rhabdomyosarcoma10.0DES, ACTC1, WT1
48pulmonary alveolar proteinosis10.0MUC1, KRT19
49mucoepidermoid carcinoma10.0MUC1, ACTC1, KRT7
50alveolar soft part sarcoma10.0DES, VIM

Graphical network of the top 20 diseases related to Cystic Nephroma:



Diseases related to cystic nephroma

Symptoms for Cystic Nephroma

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Drugs & Therapeutics for Cystic Nephroma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Cystic Nephroma

Search NIH Clinical Center for Cystic Nephroma

Genetic Tests for Cystic Nephroma

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Anatomical Context for Cystic Nephroma

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33MalaCards
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MalaCards organs/tissues related to Cystic Nephroma:

33
Kidney, Lung

Animal Models for Cystic Nephroma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cystic Nephroma:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9WT1, DICER1, MME, MUC1
2MP:00053698.4DES, PGR, VIM, ACTC1, WT1
3MP:00020068.3PGR, MUC1, DICER1, KRT19
4MP:00107718.3KRT19, DICER1, MME, MUC1, PGR
5MP:00053798.2PGR, MUC1, DICER1, KRT19, WT1
6MP:00028738.0PGR, MUC1, DICER1, ACTC1, KRT19, WT1
7MP:00053808.0PGR, VIM, DICER1, KRT19, WT1
8MP:00053897.9WT1, KRT19, DICER1, VIM, PGR
9MP:00053857.6WT1, DES, PGR, VIM, DICER1, ACTC1
10MP:00107687.5DES, PGR, VIM, DICER1, ACTC1, KRT19
11MP:00053767.4DES, PGR, VIM, MUC1, MME, DICER1
12MP:00053847.1PGR, VIM, DICER1, ACTC1, KRT7, KRT19

Publications for Cystic Nephroma

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52PubMed
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Articles related to Cystic Nephroma:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Renal metastasis of an ovarian granulosa cell tumour inducing growth of a cystic nephroma. (23843415)
2013
2
Cystic nephroma: a diagnostic dilemma. (20427881)
2010
3
What is a cystic nephroma? (20035151)
2010
4
Germline DICER1 mutations and familial cystic nephroma. (21036787)
2010
5
Cystic nephroma: a fine needle aspiration diagnostic pitfall. (20391987)
2010
6
Cystic nephroma in childhood. (19661676)
2009
7
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. (18313107)
2008
8
Failure of percutaneous endoscopic resection of a renal cystic nephroma on longer-term follow-up. (18613780)
2008
9
Cystic nephroma and localized renal cystic disease in children: diagnostic clues and management. (18970929)
2008
10
Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? (18006141)
2008
11
Treatment of cystic nephroma and cystic partially differentiated nephroblastoma--a report from the SIOP/GPOH study group. (17162067)
2007
12
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. (23132986)
2007
13
Cystic nephroma: report of a case and review of the literature. (18019431)
2007
14
Familial multilocular cystic nephroma: a variant of a unique renal neoplasm. (17656243)
2007
15
Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. (17414095)
2007
16
An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association. (16808637)
2006
17
Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. (17098684)
2006
18
Benign cystic nephroma. (16447413)
2006
19
Percutaneous treatment of renal cystic nephroma. (16053364)
2005
20
Corpora albicantia-like bodies in cystic nephroma: yet another similarity to mixed epithelial stromal tumor of kidney. (15864392)
2005
21
Familial cystic nephroma in two siblings with pleuropulmonary blastoma. (15864358)
2005
22
A complicated case of bilateral cystic nephroma in a 16-month-old boy. (16273373)
2005
23
Cystic nephroma in adults. A report of two cases and review of the literature. (16092672)
2005
24
Cystic nephroma: a benign renal tumor of children and adults. (12773993)
2003
25
Enucleative surgery in an infant with giant cystic nephroma. (12629399)
2003
26
Benign multilocular cystic nephroma. (12921324)
2003
27
Synchronous occurrence of pleuropulmonary blastoma and cystic nephroma: possible genetic link in cystic lesions of the lung and the kidney. (10881016)
2000
28
Association of cystic nephroma with angiomyolipoma in the same kidney. (10982023)
2000
29
Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. (9503503)
1998
30
Multilocular cystic nephroma: an unusual localization. (9801126)
1998
31
Cystic nephroma: a rare benign renal tumor. (9563049)
1998
32
Solitary multilocular cyst of kidney (cystic nephroma). (7558107)
1995
33
Fine-needle aspiration of cystic nephroma (multilocular cyst of the kidney). (1322260)
1992
34
Cystic nephroma: cytologic findings in fine-needle aspiration cytology. (1334828)
1992
35
Cystic nephroma--an unusual cystic renal lesion. (1344162)
1992
36
Multilocular cystic nephroma with neoplastic elements. (1661002)
1991
37
Multilocular cyst (multilocular cystic nephroma) of the kidney: a report of 2 cases with an unusual mode of presentation. (2545928)
1989
38
Actual approach to cystic nephroma. (2844542)
1988
39
Ultrasound case of the day. Multilocular cystic nephroma. (2832880)
1988
40
MRI of multilocular cystic nephroma. (2847389)
1988
41
Multilocular cystic nephroma: report of three cases. (3028697)
1987
42
Multilocular cystic nephroma: report of two cases. (2832498)
1987
43
Multilocular cystic nephroma in an adult: immunohistochemical study. (3037125)
1987
44
Cystic nephroma in children. Report of a case. (3006308)
1986
45
Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. (6294736)
1983
46
Case of the month. Benign multilocular cystic nephroma. (6313957)
1983
47
Cystic nephroma: morphologic spectrum and implications. (6287691)
1982
48
Cross-sectional imaging of multilocular cystic nephroma. (6287041)
1982
49
Cystic nephroma (so-called polycystic Wilms' tumor) of childhood: a CT-pathologic study. (232374)
1979
50
Cystic nephroma. (199349)
1977

Variations for Cystic Nephroma

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Expression for genes affiliated with Cystic Nephroma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Nephroma

Search GEO for disease gene expression data for Cystic Nephroma.

Pathways for genes affiliated with Cystic Nephroma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Cystic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.6VIM, DES
2
Show member pathways
9.3ACTC1, VIM, DES
38.6VIM, KRT7, KRT19
48.0KRT19, KRT7, ACTC1, VIM, DES

Compounds for genes affiliated with Cystic Nephroma

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Cystic Nephroma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1orcein459.7DES, VIM, ACTC1
2eosin459.7MUC1, VIM
3procollagen459.6ACTC1, VIM, DES
4s 100459.3DES, VIM, MUC1, ACTC1
5biotin45 24 1111.3DES, VIM, MUC1, ACTC1
6toluene diisocyanate459.3KRT19, MME
7bromodeoxyuridine459.1KRT19, MME, VIM, DES
8cytarabine45 51 1111.1VIM, MUC1, MME
9actinomycin d459.1DES, VIM, MUC1, MME
10progestin459.0MUC1, VIM, PGR, DES
11dihydrotestosterone45 29 24 1112.0DES, PGR, VIM, MUC1
12forskolin45 51 1110.9VIM, MUC1, MME, WT1
13cyclosporin a45 29 6110.9PGR, MME, ACTC1, WT1
14lysine458.9DES, VIM, MME, WT1
15butyrate458.8WT1, KRT19, MUC1, VIM
1612-o-tetradecanoylphorbol 13-acetate458.8WT1, MME, MUC1, VIM, DES
17oxygen45 249.7KRT19, ACTC1, MME, MUC1, DES
18lactate458.7KRT19, MME, VIM, DES
19thymidine45 249.7DES, MUC1, MME, KRT19, WT1
20hyaluronic acid45 249.6WT1, KRT19, MUC1, VIM, DES
21adenylate458.6MME, VIM, PGR, DES
22doxorubicin45 51 1110.6DES, PGR, VIM, MME, WT1
23reticulin458.5DES, VIM, MUC1, ACTC1, KRT7
24dexamethasone45 51 29 1111.5PGR, VIM, MUC1, MME, ACTC1
25mucicarmine458.5DES, VIM, MUC1, ACTC1, KRT7
26vitamin a45 24 1110.5KRT7, MME, VIM, PGR
27estradiol45 24 1110.5KRT19, MUC1, VIM, PGR, DES
28methotrexate51 45 1110.4PGR, VIM, MUC1, KRT7
29iron45 249.4DES, VIM, ACTC1, KRT7, KRT19
30retinoid458.3KRT19, KRT7, VIM, PGR
31steroid458.3DES, PGR, MME, ACTC1, KRT19, WT1
32arginine458.2DES, VIM, MME, KRT7, WT1
33ribonucleic acid458.2PGR, MUC1, MME, ACTC1, KRT19, WT1
34adriamycin458.1DES, PGR, VIM, MUC1, MME, KRT19
35serine458.1DES, VIM, MUC1, MME, KRT19, WT1
36cysteine458.1DES, PGR, VIM, MUC1, MME, WT1
37glucose458.1DES, MUC1, MME, ACTC1, KRT7, KRT19
38hematoxylin458.0DES, VIM, MUC1, ACTC1, KRT7, KRT19
39formaldehyde45 249.0DES, VIM, MUC1, ACTC1, KRT7, KRT19
40creatinine458.0DES, VIM, MUC1, MME, ACTC1, KRT19
41glycogen45 249.0DES, VIM, MUC1, ACTC1, KRT7, KRT19
42matrigel457.9VIM, MUC1, MME, ACTC1, KRT7, KRT19
43tyrosine457.6DES, MUC1, MME, ACTC1, KRT7, KRT19
44b 723457.6DES, VIM, MUC1, ACTC1, KRT7, KRT19
45paraffin456.6WT1, DES, PGR, KRT19, KRT7, ACTC1
46progesterone45 29 61 24 1110.6DES, PGR, VIM, MUC1, MME, ACTC1
47testosterone45 61 24 119.6DES, PGR, VIM, MUC1, MME, ACTC1
48vegf456.6DES, PGR, VIM, MUC1, MME, ACTC1
49estrogen456.6DES, PGR, VIM, MUC1, MME, ACTC1
50retinoic acid45 247.6DES, PGR, VIM, MUC1, MME, ACTC1

GO Terms for genes affiliated with Cystic Nephroma

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16Gene Ontology
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Cellular components related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.3KRT19, ACTC1, MME, MUC1, VIM
2intermediate filamentGO:0058828.0KRT19, KRT7, VIM, DES

Biological processes related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, VIM, DES

Molecular functions related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.6DICER1, VIM
2structural constituent of cytoskeletonGO:0052009.3KRT19, DES
3protein bindingGO:0055156.0WT1, DES, PGR, VIM, MUC1, MME

Products for genes affiliated with Cystic Nephroma

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Sources for Cystic Nephroma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet