MCID: CYS007
MIFTS: 42

Cystic Nephroma malady

Nephrological diseases category

Summaries for Cystic Nephroma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

MalaCards: Cystic Nephroma, also known as benign cystic nephroma, is related to nephroblastoma and adenoma. An important gene associated with Cystic Nephroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Keratin filaments. The compounds dexamethasone and glycogen have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung, and related mouse phenotypes are homeostasis/metabolism and muscle.

Aliases & Classifications for Cystic Nephroma

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8Disease Ontology, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

cystic nephroma 8 10
benign cystic nephroma 60


External Ids:

Disease Ontology8 DOID:2673

Related Diseases for Cystic Nephroma

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17GeneCards, 18GeneDecks
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Diseases in the Cystic Nephroma family:

Malignant Cystic Nephroma

Diseases related to Cystic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1nephroblastoma30.5WT1
2adenoma30.1KRT7, MUC1, KRT19, ACTC1
3angiomyolipoma30.1ACTC1, PGR, DES, VIM
4cystic kidney10.8
5pleuropulmonary blastoma10.5
6blastoma10.5
7mixed epithelial stromal tumour10.4
8malignant cystic nephroma10.4
9renal cell carcinoma10.4
10kidney disease10.2
11childhood multilocular cystic kidney neoplasm10.1
12polycystic kidney disease10.1
13kidney angiomyolipoma10.1
14malignant mesenchymoma10.1
15mesenchymoma10.1
16neuroblastoma10.1
17renal adenoma10.1
18renal pelvis carcinoma10.1
19hemangioma10.0ACTC1
20infantile myofibromatosis10.0DES
21papilloma10.0ACTC1
22lipoma10.0DES
23fasciitis10.0ACTC1
24congestive heart failure10.0MME
25bladder carcinoma10.0KRT19
26glomerulonephritis10.0MME
27benign mesothelioma10.0WT1
28ductal carcinoma in situ10.0PGR
29thyroid cancer10.0KRT19
30synovial sarcoma10.0KRT7
31leiomyomatosis10.0PGR
32renal oncocytoma10.0KRT7
33mixed cell type cancer10.0KRT7
34desmoid tumor10.0DES, ACTC1
35benign meningioma10.0PGR
36cystadenocarcinoma10.0MUC1
37hemangioblastoma10.0MUC1
38medulloblastoma10.0DES, ACTC1
39acute leukemia10.0WT1
40nephrogenic adenoma10.0KRT7
41uterine sarcoma10.0DES, MME
42fibrous meningioma10.0MUC1
43cutaneous fibrous histiocytoma10.0DES, ACTC1
44pseudomyxoma peritonei10.0KRT7
45oxyphilic adenoma10.0KRT7
46stomach cancer10.0KRT19
47endometriosis10.0PGR, ACTC1
48teratoma10.0KRT7, ACTC1
49myopathy10.0DES
50cystadenoma10.0MME, KRT7

Graphical network of the top 20 diseases related to Cystic Nephroma:



Diseases related to cystic nephroma

Clinical Features for Cystic Nephroma

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Drugs & Therapeutics for Cystic Nephroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cystic Nephroma

Drug clinical trials:

Search ClinicalTrials for Cystic Nephroma

Search NIH Clinical Center for Cystic Nephroma

Search CenterWatch for Cystic Nephroma

Genetic Tests for Cystic Nephroma

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Anatomical Context for Cystic Nephroma

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32MalaCards
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MalaCards organs/tissues related to Cystic Nephroma:

32
Kidney, Lung

Animal Models for Cystic Nephroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystic Nephroma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.9DICER1, DES, ACTC1, PGR
2MP:00053698.1VIM, ACTC1, PGR, DES, MEST, WT1
3MP:00053807.3PGR, MEST, KRT19, VIM, WT1, DICER1
4MP:00028737.2DICER1, WT1, PGR, MUC1, ACTC1, KRT19
5MP:00053856.9ACTC1, VIM, WT1, DICER1, MEST, DES
6MP:00107686.8WT1, DICER1, MEST, DES, PGR, KRT19
7MP:00053846.7KRT7, KRT19, PGR, MEST, DICER1, WT1

Publications for Cystic Nephroma

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50PubMed
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Articles related to Cystic Nephroma:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Renal metastasis of an ovarian granulosa cell tumour inducing growth of a cystic nephroma. (23843415)
2013
2
Case report: Multimodality imaging of a cystic nephroma. (23861515)
2013
3
Coexistence of cystic nephroma and neuroblastoma: a rare case of a childhood collision tumor. (22395847)
2012
4
Can multilocular cystic nephroma be a harbinger of multilocular cystic renal cell carcinoma? (23032854)
2012
5
Asymptomatic infantile cystic nephroma: a diagnostic dilemma. (24293912)
2012
6
Germline DICER1 mutations and familial cystic nephroma. (21036787)
2010
7
Cystic nephroma masquerading as hydatid cyst of the kidney. (21045463)
2010
8
Cystic nephroma in childhood. (19661676)
2009
9
Adult cystic nephroma: a case report and a review of the literature. (18555707)
2009
10
Clinicopathologic analysis of mixed epithelial and stromal tumor of kidney and adult cystic nephroma]. (19781188)
2009
11
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. (18313107)
2008
12
Editorial comment on: cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? (18006142)
2008
13
Sonographic diagnosis of an unusual case of multilocular cystic nephroma mimicking polycystic kidney disease. (19034827)
2008
14
Treatment of cystic nephroma and cystic partially differentiated nephroblastoma--a report from the SIOP/GPOH study group. (17162067)
2007
15
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. (23132986)
2007
16
Cystic nephroma: report of a case and review of the literature. (18019431)
2007
17
Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. (17098684)
2006
18
Cystic renal cell carcinoma arising from multilocular cystic nephroma of the same kidney. (16650296)
2006
19
Percutaneous treatment of renal cystic nephroma. (16053364)
2005
20
A complicated case of bilateral cystic nephroma in a 16-month-old boy. (16273373)
2005
21
Cystic nephroma. (15695874)
2005
22
Local recurrence of a unilateral cystic nephroma. (15147551)
2004
23
Cystic nephroma: a histologic and immunohistochemical study of 10 cases. (15578885)
2004
24
Enucleative surgery in an infant with giant cystic nephroma. (12629399)
2003
25
Congenital cystic mesoblastic nephroma. (12721740)
2003
26
Cystic atypical mesoblastic nephroma. (11956777)
2002
27
Cystic nephroma: a rare clinical entity. (12549633)
2002
28
Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. (9503503)
1998
29
Quiz case of the month. Multilocular cystic nephroma (MLCN). (9221171)
1997
30
Dedifferentiated cystic nephroma with malignant mesenchymoma as the dedifferentiated component. (9025898)
1996
31
Partial nephrectomy in a metachronous multilocular cyst of the kidney (cystic nephroma). (8158788)
1994
32
Familial cystic nephroma and pleuropulmonary blastoma. (8280234)
1993
33
Familial cystic nephroma and pleuropulmonary blastoma. (8382107)
1993
34
Giant cystic nephroma in an adult. Case report. (1337954)
1992
35
Wilms' tumour associated with deep cystic nephroma-like changes: three cases of a putative Wilms' tumour precursor. (1849118)
1991
36
Multilocular cystic nephroma. (2162227)
1990
37
Multilocular cystic nephroma: MR findings. (2554703)
1989
38
Cystic nephroma: an emerging entity. (2557790)
1989
39
General diagnosis case of the day. Multilocular cystic nephroma (MLCN). (2541603)
1989
40
Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma. Terminology and criteria for diagnosis. (2544253)
1989
41
Actual approach to cystic nephroma. (2844542)
1988
42
Ultrasound case of the day. Multilocular cystic nephroma. (2832880)
1988
43
Multilocular cystic nephroma: report of three cases. (3028697)
1987
44
Multilocular cystic nephroma: report of two cases. (2832498)
1987
45
Multilocular cystic nephroma simulating Wilms' tumour. (2825277)
1987
46
Cystic mesoblastic nephroma. (6277070)
1982
47
Cystic nephroma: morphologic spectrum and implications. (6287691)
1982
48
Computed tomography of multilocular cystic nephroma. (7244215)
1981
49
Cystic nephroma: an ultrastructural and biochemical study. (225572)
1979
50
Cystic nephroma. (199349)
1977

Genetic Variations for Cystic Nephroma

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Expression for genes affiliated with Cystic Nephroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Nephroma

Search GEO for disease gene expression data for Cystic Nephroma.

Pathways for genes affiliated with Cystic Nephroma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Cystic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4VIM, DES, ACTC1
28.6KRT19, KRT7, VIM
38.0ACTC1, KRT7, KRT19, DES, VIM

Compounds for genes affiliated with Cystic Nephroma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Cystic Nephroma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1dexamethasone44 49 28 1113.5MME
2glycogen44 2411.1KRT7, ACTC1
3vitamin a44 11 2412.0VIM, MME
4eosin449.8VIM, MUC1
5orcein449.8DES, VIM, ACTC1
62-methoxyethanol449.7ACTC1, VIM
7toluene diisocyanate449.6KRT19, MME
8toluidine449.6DES, VIM
9oxygen44 2410.5DES, MUC1, MME
10imatinib44 49 1111.5ACTC1, DES, WT1
11cytarabine44 49 1111.4VIM, MUC1, MME
12dihydrotestosterone44 28 11 2412.4PGR, DES, VIM
13carbohydrates449.4KRT19
14s 100449.3DES, MUC1, ACTC1, VIM
15biotin44 11 2411.3DES, MUC1, ACTC1, VIM
16actinomycin d449.1VIM, DES, MUC1, MME
17lysine449.0MME, WT1, VIM, DES
18forskolin44 49 1111.0WT1, VIM, MME, MUC1
19cyclosporin a44 28 5911.0PGR, ACTC1, WT1, MME
20progestin449.0VIM, MUC1, DES, PGR
21bromodeoxyuridine448.9KRT19, VIM, DES, MME
2212-o-tetradecanoylphorbol 13-acetate448.9MME, MUC1, DES, WT1, VIM
23reticulin448.8DES, ACTC1, KRT7, MUC1, VIM
24mucicarmine448.8VIM, DES, MUC1, KRT7, ACTC1
25glucose448.7KRT19, MUC1, ACTC1, KRT7
26doxorubicin44 49 1110.7MME, VIM, WT1, DES, PGR
27arginine448.7VIM, MME, DES, WT1, KRT7
28methotrexate44 49 1110.7VIM, MUC1, KRT7, PGR
29thymidine44 249.5MME, KRT19, MUC1, WT1, DES
30lactate448.5VIM, DES, KRT19, MME
31iron44 249.4ACTC1, KRT7, KRT19, DES, VIM
32hyaluronic acid44 249.4DES, MUC1, VIM, KRT19, WT1
33retinoid448.3KRT7, KRT19, PGR, VIM
34cysteine448.2DES, MME, MUC1, PGR, VIM, WT1
35estradiol44 11 2410.1PGR, MUC1, DES, VIM, KRT19
36steroid448.1DES, PGR, MME, KRT19, WT1, ACTC1
37hematoxylin448.0DES, ACTC1, KRT7, KRT19, MUC1, VIM
38formaldehyde44 249.0DES, MUC1, VIM, KRT19, KRT7, ACTC1
39ribonucleic acid448.0WT1, MUC1, PGR, KRT19, MME, ACTC1
40matrigel448.0VIM, MUC1, KRT19, KRT7, ACTC1, MME
41adriamycin447.9KRT19, VIM, DES, MUC1, PGR, MME
42serine447.8KRT19, MME, MUC1, DES, WT1, VIM
43creatinine447.8WT1, ACTC1, KRT19, MME, VIM, DES
44tyrosine447.7MUC1, DES, MME, KRT19, KRT7, ACTC1
45b 723447.6KRT7, ACTC1, DES, KRT19, VIM, MUC1
46paraffin446.7ACTC1, KRT7, KRT19, MME, PGR, MUC1
47progesterone44 59 28 11 2410.7ACTC1, KRT7, KRT19, PGR, MUC1, DES
48testosterone44 59 11 249.7DES, WT1, MUC1, VIM, PGR, MME
49vegf446.7MME, DES, ACTC1, KRT7, KRT19, PGR
50retinoic acid44 247.6MME, PGR, MUC1, DES, WT1, VIM

GO Terms for genes affiliated with Cystic Nephroma

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16Gene Ontology
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Cellular components related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058828.3KRT7, KRT19, DES, VIM

Biological processes related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.4ACTC1, DES, VIM

Molecular functions related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052008.5KRT19, DES, VIM
2protein bindingGO:0055156.1WT1, DICER1, DES, MUC1, PGR, MME

Products for genes affiliated with Cystic Nephroma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystic Nephroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet