MCID: CYS007
MIFTS: 45

Cystic Nephroma malady

Cancer diseases, Nephrological diseases categories

Summaries for Cystic Nephroma

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Wikipedia:64 A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST)... more...

MalaCards based summary: Cystic Nephroma, also known as benign cystic nephroma, is related to adenoma and angiomyolipoma. An important gene associated with Cystic Nephroma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Aurora B signaling and Striated Muscle Contraction. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung, and related mouse phenotypes are liver/biliary system and muscle.

Aliases & Classifications for Cystic Nephroma

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Cystic Nephroma, Aliases & Descriptions:

Name: Cystic Nephroma 9 11
 
Benign Cystic Nephroma 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:2673

Related Diseases for Cystic Nephroma

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Diseases in the Cystic Nephroma family:

Malignant Cystic Nephroma

Diseases related to Cystic Nephroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.0MUC1, ACTC1, KRT7, KRT19
2angiomyolipoma30.0DES, PGR, VIM, ACTC1
3wilms tumor29.8DES, VIM, MME, ACTC1, KRT7, WT1
4sarcoma29.6DES, VIM, MUC1, ACTC1, WT1
5pleuropulmonary blastoma10.6
6blastoma10.6
7infantile myofibromatosis10.5DES
8fasciitis10.5ACTC1
9kidney cancer10.5KRT7
10cystadenocarcinoma10.5MUC1
11nephrogenic adenoma10.5KRT7
12fibrous meningioma10.5MUC1
13hidradenoma10.4MUC1
14renal cell carcinoma10.4
15malignant cystic nephroma10.4
16nephroblastoma10.4
17pseudomyxoma peritonei10.4KRT7
18leiomyomatosis10.4PGR
19desmoid tumor10.4DES, ACTC1
20ductal carcinoma in situ10.4PGR
21multilocular cystic renal cell carcinoma10.4
22cutaneous fibrous histiocytoma10.4DES, ACTC1
23synovial sarcoma10.4KRT7
24uterine sarcoma10.3DES, MME
25hemangioma10.3ACTC1
26cystadenoma10.3KRT7, MME
27metanephric adenoma10.3KRT7, WT1
28mixed epithelial stromal tumour10.3
29mucinous cystadenocarcinoma10.3MUC1, KRT7
30cutaneous paget's disease10.3MUC1, KRT7
31thymus cancer10.3MUC1, KRT7
32alveolar rhabdomyosarcoma10.3WT1, DES
33ovarian brenner tumor10.3KRT7, WT1
34lymphangioleiomyomatosis10.3DES, PGR
35syringoma10.2MUC1, KRT19
36dysgerminoma10.2WT1, KRT7
37bile duct adenoma10.2KRT7, KRT19
38cervical adenocarcinoma10.2PGR, KRT7
39breast fibroadenoma10.2MME, PGR
40bowen syndrome10.2KRT7, KRT19
41embryonal rhabdomyosarcoma10.2DES, ACTC1, WT1
42pulmonary alveolar proteinosis10.2MUC1, KRT19
43mucoepidermoid carcinoma10.2MUC1, ACTC1, KRT7
44alveolar soft part sarcoma10.2DES, VIM
45myoepithelioma10.2VIM, ACTC1
46granular cell tumor10.1DES, VIM
47childhood multilocular cystic kidney neoplasm10.1
48polycystic kidney disease10.1
49kidney disease10.1
50malignant mesenchymoma10.1

Graphical network of the top 20 diseases related to Cystic Nephroma:



Diseases related to cystic nephroma

Symptoms for Cystic Nephroma

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Drugs & Therapeutics for Cystic Nephroma

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Drug clinical trials:

Search ClinicalTrials for Cystic Nephroma

Search NIH Clinical Center for Cystic Nephroma

Genetic Tests for Cystic Nephroma

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Anatomical Context for Cystic Nephroma

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MalaCards organs/tissues related to Cystic Nephroma:

32
Kidney, Lung

Animal Models for Cystic Nephroma or affiliated genes

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MGI Mouse Phenotypes related to Cystic Nephroma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9WT1, DICER1, MME, MUC1
2MP:00053698.4DES, PGR, VIM, ACTC1, WT1
3MP:00020068.3PGR, MUC1, DICER1, KRT19
4MP:00107718.3KRT19, DICER1, MME, MUC1, PGR
5MP:00053798.2PGR, MUC1, DICER1, KRT19, WT1
6MP:00028738.0PGR, MUC1, DICER1, ACTC1, KRT19, WT1
7MP:00053808.0PGR, VIM, DICER1, KRT19, WT1
8MP:00053897.9WT1, KRT19, DICER1, VIM, PGR
9MP:00053857.6WT1, DES, PGR, VIM, DICER1, ACTC1
10MP:00107687.5DES, PGR, VIM, DICER1, ACTC1, KRT19
11MP:00053767.4DES, PGR, VIM, MUC1, MME, DICER1
12MP:00053847.1PGR, VIM, DICER1, ACTC1, KRT7, KRT19

Publications for Cystic Nephroma

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Articles related to Cystic Nephroma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Multilocular cystic nephroma: A clinical case. (24892395)
2014
2
Quiz page JULY 2014: bilateral abdominal masses in an infant. Diagnosis: Bilateral cystic nephroma. (24954459)
2014
3
Uretheral invagination of multilocular cystic nephroma; a case report of a new pathologic variant. (25197409)
2014
4
Renal metastasis of an ovarian granulosa cell tumour inducing growth of a cystic nephroma. (23843415)
2013
5
Cystic nephroma: a diagnostic dilemma. (20427881)
2010
6
What is a cystic nephroma? (20035151)
2010
7
Germline DICER1 mutations and familial cystic nephroma. (21036787)
2010
8
Cystic nephroma in childhood. (19661676)
2009
9
Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. (18313107)
2008
10
Failure of percutaneous endoscopic resection of a renal cystic nephroma on longer-term follow-up. (18613780)
2008
11
Cystic nephroma and localized renal cystic disease in children: diagnostic clues and management. (18970929)
2008
12
Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? (18006141)
2008
13
Treatment of cystic nephroma and cystic partially differentiated nephroblastoma--a report from the SIOP/GPOH study group. (17162067)
2007
14
Benign multilocular cyst or multilocular cystic nephroma in adults: three case reports. (23132986)
2007
15
Cystic nephroma: report of a case and review of the literature. (18019431)
2007
16
Familial multilocular cystic nephroma: a variant of a unique renal neoplasm. (17656243)
2007
17
Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. (17414095)
2007
18
An association of pleuropulmonary blastoma and cystic nephroma: possible genetic association. (16808637)
2006
19
Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. (17098684)
2006
20
Benign cystic nephroma. (16447413)
2006
21
Percutaneous treatment of renal cystic nephroma. (16053364)
2005
22
Corpora albicantia-like bodies in cystic nephroma: yet another similarity to mixed epithelial stromal tumor of kidney. (15864392)
2005
23
Familial cystic nephroma in two siblings with pleuropulmonary blastoma. (15864358)
2005
24
A complicated case of bilateral cystic nephroma in a 16-month-old boy. (16273373)
2005
25
Cystic nephroma in adults. A report of two cases and review of the literature. (16092672)
2005
26
Cystic nephroma: a benign renal tumor of children and adults. (12773993)
2003
27
Enucleative surgery in an infant with giant cystic nephroma. (12629399)
2003
28
Synchronous occurrence of pleuropulmonary blastoma and cystic nephroma: possible genetic link in cystic lesions of the lung and the kidney. (10881016)
2000
29
Association of cystic nephroma with angiomyolipoma in the same kidney. (10982023)
2000
30
Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. (9503503)
1998
31
Multilocular cystic nephroma: an unusual localization. (9801126)
1998
32
Solitary multilocular cyst of kidney (cystic nephroma). (7558107)
1995
33
Fine-needle aspiration of cystic nephroma (multilocular cyst of the kidney). (1322260)
1992
34
Cystic nephroma: cytologic findings in fine-needle aspiration cytology. (1334828)
1992
35
Cystic nephroma--an unusual cystic renal lesion. (1344162)
1992
36
Multilocular cystic nephroma with neoplastic elements. (1661002)
1991
37
Multilocular cyst (multilocular cystic nephroma) of the kidney: a report of 2 cases with an unusual mode of presentation. (2545928)
1989
38
Actual approach to cystic nephroma. (2844542)
1988
39
Ultrasound case of the day. Multilocular cystic nephroma. (2832880)
1988
40
MRI of multilocular cystic nephroma. (2847389)
1988
41
Multilocular cystic nephroma: report of three cases. (3028697)
1987
42
Multilocular cystic nephroma: report of two cases. (2832498)
1987
43
Multilocular cystic nephroma in an adult: immunohistochemical study. (3037125)
1987
44
Cystic nephroma in children. Report of a case. (3006308)
1986
45
Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. (6294736)
1983
46
Case of the month. Benign multilocular cystic nephroma. (6313957)
1983
47
Cystic nephroma: morphologic spectrum and implications. (6287691)
1982
48
Cross-sectional imaging of multilocular cystic nephroma. (6287041)
1982
49
Cystic nephroma (so-called polycystic Wilms' tumor) of childhood: a CT-pathologic study. (232374)
1979
50
Cystic nephroma. (199349)
1977

Variations for Cystic Nephroma

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Expression for genes affiliated with Cystic Nephroma

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Expression patterns in normal tissues for genes affiliated with Cystic Nephroma

Search GEO for disease gene expression data for Cystic Nephroma.

Pathways for genes affiliated with Cystic Nephroma

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Pathways related to Cystic Nephroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.6VIM, DES
2
Show member pathways
9.3ACTC1, VIM, DES
38.6VIM, KRT7, KRT19
48.0KRT19, KRT7, ACTC1, VIM, DES

Compounds for genes affiliated with Cystic Nephroma

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Compounds related to Cystic Nephroma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1orcein449.7VIM, DES, ACTC1
2eosin449.7MUC1, VIM
3procollagen449.6DES, VIM, ACTC1
4s 100449.3MUC1, ACTC1, VIM, DES
5biotin44 25 1211.3ACTC1, MUC1, VIM, DES
6toluene diisocyanate449.3KRT19, MME
7bromodeoxyuridine449.1MME, KRT19, VIM, DES
8cytarabine44 50 1211.1VIM, MUC1, MME
9actinomycin d449.1VIM, DES, MME, MUC1
10progestin449.0DES, VIM, MUC1, PGR
11dihydrotestosterone44 29 25 1212.0DES, PGR, VIM, MUC1
12forskolin44 50 1210.9VIM, MUC1, MME, WT1
13cyclosporin a44 29 6010.9ACTC1, WT1, MME, PGR
14lysine448.9DES, WT1, VIM, MME
15butyrate448.8VIM, MUC1, KRT19, WT1
1612-o-tetradecanoylphorbol 13-acetate448.8DES, VIM, MUC1, MME, WT1
17oxygen44 259.7MME, KRT19, ACTC1, MUC1, DES
18lactate448.7VIM, DES, MME, KRT19
19thymidine44 259.7DES, WT1, KRT19, MME, MUC1
20hyaluronic acid44 259.6WT1, KRT19, MUC1, DES, VIM
21adenylate448.6MME, DES, PGR, VIM
22doxorubicin44 50 1210.6WT1, VIM, MME, PGR, DES
23reticulin448.5ACTC1, MUC1, VIM, DES, KRT7
24dexamethasone44 50 29 1211.5VIM, MME, ACTC1, PGR, MUC1
25mucicarmine448.5VIM, KRT7, ACTC1, MUC1, DES
26vitamin a44 25 1210.5KRT7, MME, VIM, PGR
27estradiol44 25 1210.5DES, PGR, VIM, MUC1, KRT19
28methotrexate50 44 1210.4KRT7, VIM, PGR, MUC1
29iron44 259.4KRT7, ACTC1, KRT19, VIM, DES
30retinoid448.3PGR, KRT7, KRT19, VIM
31steroid448.3KRT19, MME, ACTC1, PGR, DES, WT1
32arginine448.2KRT7, DES, VIM, MME, WT1
33ribonucleic acid448.2WT1, KRT19, MME, ACTC1, PGR, MUC1
34adriamycin448.1VIM, MME, KRT19, MUC1, PGR, DES
35serine448.1WT1, KRT19, MME, MUC1, VIM, DES
36cysteine448.1PGR, VIM, MUC1, MME, DES, WT1
37glucose448.1MME, ACTC1, MUC1, KRT7, KRT19, DES
38hematoxylin448.0VIM, ACTC1, KRT7, KRT19, DES, MUC1
39formaldehyde44 259.0MUC1, ACTC1, DES, KRT19, KRT7, VIM
40creatinine448.0DES, WT1, MME, ACTC1, KRT19, MUC1
41glycogen44 259.0KRT19, DES, VIM, MUC1, ACTC1, KRT7
42matrigel447.9KRT7, ACTC1, MME, MUC1, VIM, KRT19
43tyrosine447.6WT1, ACTC1, DES, MME, MUC1, KRT7
44b 723447.6DES, VIM, MUC1, ACTC1, KRT7, WT1
45paraffin446.6MME, DES, WT1, VIM, MUC1, KRT19
46progesterone44 29 60 25 1210.6ACTC1, KRT7, KRT19, WT1, MUC1, DES
47testosterone44 60 25 129.6PGR, MUC1, DES, ACTC1, KRT7, WT1
48vegf446.6VIM, MUC1, MME, ACTC1, KRT19, KRT7
49estrogen446.6KRT19, ACTC1, MME, MUC1, VIM, PGR
50retinoic acid44 257.6VIM, MME, PGR, ACTC1, DES, KRT7

GO Terms for genes affiliated with Cystic Nephroma

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Cellular components related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.3KRT19, ACTC1, MME, MUC1, VIM
2intermediate filamentGO:0058828.0KRT19, KRT7, VIM, DES

Biological processes related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, VIM, DES

Molecular functions related to Cystic Nephroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.6DICER1, VIM
2structural constituent of cytoskeletonGO:0052009.3KRT19, DES
3protein bindingGO:0055156.0WT1, DES, PGR, VIM, MUC1, MME

Products for genes affiliated with Cystic Nephroma

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Sources for Cystic Nephroma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet