MCID: CYS017
MIFTS: 41

Cystic Teratoma malady

Summaries for Cystic Teratoma

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33MalaCards
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MalaCards: Cystic Teratoma, also known as cystic teratoma, nos, is related to teratoma and squamous cell carcinoma. An important gene associated with Cystic Teratoma is TP53 (tumor protein p53), and among its related pathways are Selected targets of Oct-3/4 and Hematopoietic cell lineage. The compounds estrogen and sialic acid have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cystic Teratoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

cystic teratoma 8 61
cystic teratoma, nos 8


External Ids:

Disease Ontology8 DOID:2660
SNOMED-CT57 42717009
NCIt40 C9014

Related Diseases for Cystic Teratoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cystic Teratoma family:

adult cystic teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1teratoma32.0ACTC1, KRT7, NKX2-1, CGB
2squamous cell carcinoma31.3TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
3adenocarcinoma31.1TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
4pseudomyxoma peritonei30.6KRT20, KRT7, CDX2, MUC5AC, MUC2
5mucinous cystadenocarcinoma30.5KRT20, KRT7, MUC16
6cystadenoma30.4KRT7, MME
7adenosquamous carcinoma30.3KRT20, KRT7, MUC5AC, MUC2, NKX2-1
8paraganglioma30.2SYP
9angiosarcoma30.2ACTC1, KRT18, CALB2
10papillary carcinoma30.2ACTC1, KRT20, KRT7, KRT18, MUC16, MUC2
11adenoma30.2TP53, ACTC1, KRT20, KRT7, KRT18, CDX2
12sertoli-leydig cell tumor30.0KRT7, CALB2
13sertoli cell tumor30.0SYP, CALB2
14struma ovarii30.0MUC16, NKX2-1
15large cell carcinoma30.0KRT20, KRT7, SYP, NKX2-1
16neuroendocrine carcinoma30.0KRT20, KRT7, KRT18, CDX2, SYP, NKX2-1
17ovarian cystic teratoma11.1
18malignant ovarian cyst10.7
19mediastinum teratoma10.6
20adult cystic teratoma10.5
21fallopian tube teratoma10.5
22ovarian squamous cell carcinoma10.5
23adult teratoma10.5
24mucinous adenocarcinoma10.4
25small cell carcinoma10.4
26anal squamous cell carcinoma10.4
27ectopic pregnancy10.4
28prostatic cyst10.3
29ovarian mucinous cystadenocarcinoma10.3
30hypercalcemia10.3
31paget disease, extramammary10.3
32amelanotic melanoma10.2
33ovarian mucinous adenocarcinoma10.2
34cystic lymphangioma10.2
35thyroiditis10.2
36renal dysplasia, cystic10.2
37renal dysplasia10.2
38cardiac tamponade10.0
39parathyroid carcinoma10.0
40sebaceous adenoma10.0
41choroid plexus papilloma10.0
42cystic echinococcosis10.0
43blastoma10.0
44serous cystadenocarcinoma10.0
45papillary cystadenocarcinoma10.0
46thyroid lymphoma10.0
47mucinous ovarian cystadenoma10.0
48muir-torre syndrome10.0
49pleomorphic carcinoma10.0
50pleuropulmonary blastoma10.0

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to cystic teratoma

Clinical Features for Cystic Teratoma

Drugs & Therapeutics for Cystic Teratoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Cystic Teratoma

Drug clinical trials:

Search ClinicalTrials for Cystic Teratoma

Search NIH Clinical Center for Cystic Teratoma

Search CenterWatch for Cystic Teratoma

Genetic Tests for Cystic Teratoma

Anatomical Context for Cystic Teratoma

Animal Models for Cystic Teratoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cystic Teratoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5TP53, KRT10, CDX2, MUC2, NRAS, NKX2-1
2MP:00053818.8TP53, CA9, NKX2-1, NRAS, MUC2, MUC5AC

Publications for Cystic Teratoma

Sources:
51PubMed
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Articles related to Cystic Teratoma:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Choroid plexus papilloma arising in a mature cystic teratoma of a 32-year-old female. (23255035)
2013
2
Two cases of primary ovarian neuroblastoma arising from mature cystic teratomas. (24371699)
2013
3
Squamous cell carcinoma arising within a mature cystic teratoma with invasion into the adjacent small intestine: a case report. (22498945)
2012
4
Mature cystic teratoma of the uterosacral ligament successfully treated with laparoendoscopic single-site surgery. (22482975)
2012
5
Intrapulmonary cystic teratoma mimicking malignant pulmonary neoplasm. (22892230)
2012
6
Dedifferentiated chondrosarcoma arising in a mature cystic teratoma of the ovary: a case report and review of the literature. (21623194)
2011
7
Posterior approach for sacrococcygeal posterior meningocele with anterior large mature cystic teratoma. (20464651)
2010
8
Primary retroperitoneal mature cystic teratoma presenting as an adrenal tumor in an adult. (20636475)
2010
9
Ovarian hemangioma occurring synchronously with contralateral mature cystic teratoma in an 81-year-old patient. (20846106)
2010
10
Rhabdomyosarcoma arising in a mature cystic teratoma with contralateral serous carcinoma: case report and review of the literature. (19483625)
2009
11
Primary malignant melanoma in cystic teratoma of ovary. (19749467)
2009
12
Oligodendroglioma arising in an ovarian mature cystic teratoma. (19483626)
2009
13
A rare case of squamous cell carcinoma arising in a mature cystic teratoma of the ovary. (18019775)
2007
14
Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. (17527072)
2007
15
Ruptured ovarian cystic teratoma secondary to blunt abdominal trauma: a very unusual case. (17308491)
2007
16
Mature cystic teratoma in the anterior mediastinum containing a carcinoid. (16538161)
2006
17
Ovarian mucinous cystadenocarcinoma of low malignant potential associated with a mature cystic teratoma. (16951785)
2006
18
Mucinous adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary--case report. (16800267)
2006
19
Malignant transformation of ovarian mature cystic teratoma. (16445624)
2006
20
Monolateral mature ovarian cystic teratoma. (15746800)
2005
21
Ovarian cystic teratoma with primary epithelial cell melanoma. (15755005)
2005
22
An ovarian mucinous adenocarcinoma arising from mature cystic teratoma associated with respiratory type tissue: a case report. (15656343)
2004
23
Mature cystic teratoma of the ovary associated with complete colonic wall and mucinous cystadenoma. (14584762)
2003
24
Granulosa cell tumor co-existing with a mature cystic teratoma of the ovary. (12918483)
2003
25
Mucinous adenocarcinoma and strumal carcinoid tumor arising in one mature cystic teratoma of the ovary with synchronous cervical cancer. (12696624)
2003
26
Small bowel perforation with minor trauma: a rare complication of an ovarian cystic teratoma. (12435956)
2002
27
Compound melanocytic nevus arising in a mature cystic teratoma of the ovary. (11844060)
2001
28
Immunohistochemical detection of parathyroid hormone-related protein in a squamous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. (11104629)
2000
29
Malignant transformation of an ovarian mature cystic teratoma presenting as a rectal mass. (10600316)
1999
30
Osteosarcoma arising in a mature cystic teratoma of the ovary. (10374685)
1999
31
Mature cystic teratoma of the mediastinum containing a carcinoid. A case report. (10323087)
1998
32
An endodermal sinus tumor arising from a mature cystic teratoma in the retroperitoneum in a child: is a mature teratoma a premalignant condition? (9781660)
1998
33
Benign cystic teratoma of unilateral fallopian tube associated with intrauterine pregnancy: a case report. (9614784)
1998
34
Well differentiated cerebellar tissue within a mature cystic teratoma. (9651951)
1998
35
Cystic teratoma of the greater omentum: a case report and review of the literature. (9311177)
1997
36
Mesenteric cystic lymphangioma: radiologic appearance mimicking cystic teratoma. (8662062)
1996
37
Cystic teratoma of the ovary mimicking a bladder stone. (8804505)
1996
38
Surgical management of benign cystic teratoma. Laparoscopy vs. laparotomy. (7473436)
1995
39
Mature cystic teratoma of the pancreas: sonographic and CT findings. (8430545)
1993
40
Squamous cell carcinoma arising in a mature cystic teratoma with metastasis to the paraaortic nodes. (8349156)
1993
41
Benign cystic teratoma manifested as an umbilical hernia. (2000537)
1991
42
The use of serum TA-4 in monitoring patients with malignant transformation of ovarian mature cystic teratoma. (2736493)
1989
43
Tubal pregnancy associated with a benign cystic teratoma of the fallopian tube. A case report. (3404520)
1988
44
Cystic teratoma in the bare area of liver. (3294587)
1987
45
Spontaneous rupture of a benign cystic teratoma. A case report. (3563798)
1987
46
Extraosseous localization of technetium-99m MDP in benign cystic teratoma. (3742914)
1986
47
Cytologic findings in an effusion caused by rupture of a benign cystic teratoma of the mediastinum into a serous cavity. (3866453)
1985
48
Acute urinary retention: a rare onset sign of ovarian cystic teratoma. (6662607)
1983
49
A study on the melanin-laden dendritic cell (melanocyte) in ovarian cystic teratoma. (676745)
1978
50
Malignant gliomatosis peritonei originating from cystic ovarian teratoma. (4447001)
1974

Genetic Variations for Cystic Teratoma

Expression for genes affiliated with Cystic Teratoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for genes affiliated with Cystic Teratoma

Sources:
12EMD Millipore, 30KEGG, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Cystic Teratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TP53, CDX2, CGB
29.9MME, CD1A, CSF1
39.7KRT18, KRT7, KRT10, ACTC1
4
Hide members
9.7MUC5AC, MUC16, MUC2

Compounds for genes affiliated with Cystic Teratoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Cystic Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6CALB2
2sialic acid4510.4KRT7
3reticulin4510.2SYP, KRT7, ACTC1
4dutp4510.2TP53, KRT10, KRT18, SYP
5crcs4510.1TP53, MME, MUC2
6h2o2459.9MME, MUC16, SYP
7sodium arsenite459.9TP53, KRT18, DUSP19
8butyrate459.9CALB2, CSF1, DUSP19, CDX2
95-aza-2deoxycytidine459.9CA9, MUC2, CDX2, KRT7, TP53
10methylcellulose459.9KRT10, KRT18, CSF1
11cytarabine45 50 1111.8CSF1, DUSP19, MME, TP53
125fluorouracil459.8TP53, KRT18, MUC5AC, MUC2, CSF1
13cyclophosphamide45 50 1111.7CSF1, CGB, MUC16, KRT18, TP53
14acetylcholine45 50 29 11 2413.7CALB2, SYP, DUSP19, MME
15actinomycin d459.7CSF1, MUC2, MME, KRT18, TP53
16ribonucleic acid459.6NKX2-1, MUC5AC, MME, KRT20, ACTC1
17formaldehyde45 2410.6NKX2-1, SYP, KRT18, KRT7, KRT20, ACTC1
18dmso459.6CSF1, DUSP19, MUC2, MUC5AC, KRT18
19matrigel459.6CSF1, CGB, MME, KRT18, KRT7, ACTC1
20retinoid459.6CSF1, MUC5AC, KRT18, KRT7, KRT10, TP53
21mucicarmine459.6CALB2, NKX2-1, SYP, KRT7, KRT20, ACTC1
22n acetylcysteine459.6CSF1, DUSP19, MUC5AC, KRT18, TP53
23thymidine45 2410.6CALB2, CSF1, CDX2, MME, KRT18, TP53
24forskolin45 50 1111.5NKX2-1, SYP, DUSP19, MUC2, MME, KRT18
25proline459.5CA9, MUC2, MUC5AC, KRT10, TP53
26glycogen45 2410.5CSF1, SYP, DUSP19, KRT18, KRT7, ACTC1
27oligonucleotide459.5NKX2-1, NRAS, MUC2, MUC5AC, CDX2, KRT18
28chloride459.5MME, MUC5AC, CSF1, CA9
29paclitaxel45 50 1111.4TP53, MUC16, DUSP19, CSF1, CALB2
30cisplatin45 50 60 1112.4CSF1, CGB, SYP, DUSP19, MUC16, TP53
31lactate459.3CA9, CSF1, CGB, MUC16, MME, KRT18
32creatinine459.3CSF1, CGB, SYP, MUC16, MME, KRT18
33b 723459.2ACTC1, KRT20, KRT7, MUC16, SYP, NKX2-1
34doxorubicin45 50 1111.2CSF1, DUSP19, MUC16, MME, KRT18, KRT20
35iron45 2410.2MUC16, KRT18, KRT7, KRT20, ACTC1
36dopamine45 29 11 2412.1CALB2, DUSP19, MME, KRT18
37dexamethasone45 50 29 1112.1NKX2-1, DUSP19, MUC2, MUC16, MUC5AC, MME
38threonine459.1NKX2-1, DUSP19, MUC2, MUC16, MUC5AC, KRT18
39cysteine459.1CSF1, CGB, SYP, DUSP19, MUC2, MUC5AC
40glucose459.0CA9, CGB, MUC2, MUC16, MUC5AC, KRT18
41steroid458.7MUC16, SYP, NKX2-1, CALB2, MUC5AC, CDX2
42calcium45 50 11 2411.5CALB2, CA9, SYP, DUSP19, MUC2, MUC5AC
43vegf458.4CA9, CSF1, CGB, SYP, MUC16, MME
44hematoxylin458.4CALB2, ACTC1, NKX2-1, SYP, MUC2, MUC16
45serine458.4CSF1, NKX2-1, SYP, DUSP19, MUC2, MUC16
46retinoic acid45 249.3MUC2, DUSP19, SYP, NKX2-1, CSF1, MUC5AC
47testosterone45 60 11 2411.3CALB2, CSF1, CGB, SYP, MUC16, MUC5AC
48paraffin457.4CA9, CSF1, NKX2-1, SYP, MUC2, MUC16
49tyrosine457.2CSF1, CA9, CALB2, NKX2-1, SYP, NRAS
50progesterone45 60 29 11 2411.2CDX2, MME, KRT18, KRT7, KRT20, KRT10

GO Terms for genes affiliated with Cystic Teratoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:04430610.0MME, SYP
2keratin filamentGO:0450959.9KRT10, KRT7, KRT18
3intermediate filamentGO:0058829.6KRT10, KRT20, KRT7, KRT18
4Golgi lumenGO:0057969.4MUC2, MUC16, MUC5AC

Biological processes related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.1TP53, MME
2O-glycan processingGO:0162669.6MUC5AC, MUC16, MUC2
3cellular protein metabolic processGO:0442678.9CGB, MUC2, MUC16, MUC5AC, MME

Products for genes affiliated with Cystic Teratoma

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Sources for Cystic Teratoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet