MCID: CYS017
MIFTS: 48

Cystic Teratoma malady

Summaries for Cystic Teratoma

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32MalaCards
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MalaCards: Cystic Teratoma, also known as cystic teratoma, nos, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Cystic Teratoma is TP53 (tumor protein p53), and among its related pathways are Selected targets of Oct-3/4 and Hematopoietic cell lineage. The compounds estrogen and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and thyroid, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cystic Teratoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

cystic teratoma 8 60
cystic teratoma, nos 8


External Ids:

Disease Ontology8 DOID:2660
SNOMED-CT56 42717009
NCIt39 C9014

Related Diseases for Cystic Teratoma

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17GeneCards, 18GeneDecks
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Diseases in the Cystic Teratoma family:

Adult Cystic Teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.2TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
2adenocarcinoma31.0TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
3melanoma30.9TP53, ACTC1, KRT18, MME, CDX2, CD1A
4pseudomyxoma peritonei30.6KRT20, KRT7, CDX2, MUC5AC, MUC2
5cystadenocarcinoma30.5MUC5AC, MUC16, MUC2
6peritonitis30.5MUC16
7mucinous cystadenocarcinoma30.5KRT20, KRT7, MUC16
8pancreatitis30.3NRAS
9cystadenoma30.3KRT7, MME
10adenosquamous carcinoma30.3KRT20, KRT7, MUC5AC, MUC2, NKX2-1
11paraganglioma30.2SYP
12leiomyoma30.2ACTC1, MME
13papilloma30.2MUC5AC, MUC2
14angiosarcoma30.2ACTC1, KRT18, CALB2
15endodermal sinus tumor30.2KRT7, MUC16, CGB
16colon adenocarcinoma30.2KRT20, MUC5AC, MUC2, CALB2
17sarcoma30.2TP53, ACTC1, CD1A, NRAS, CGB, CSF1
18papillary carcinoma30.2ACTC1, KRT20, KRT7, KRT18, MUC16, MUC2
19adenoma30.2TP53, ACTC1, KRT20, KRT7, KRT18, CDX2
20breast cancer30.1TP53, KRT7, KRT18, MME, CDX2, CD1A
21leydig cell tumor30.0CALB2
22neuroblastoma30.0TP53, SYP
23sertoli-leydig cell tumor30.0KRT7, CALB2
24hemangioma30.0ACTC1, NKX2-1
25sertoli cell tumor30.0SYP, CALB2
26meningioma30.0SYP, CALB2
27chordoma30.0KRT7, KRT18
28rhabdomyosarcoma30.0TP53, ACTC1, CALB2
29hepatoblastoma30.0KRT7, KRT18
30struma ovarii30.0MUC16, NKX2-1
31large cell carcinoma30.0KRT20, KRT7, SYP, NKX2-1
32neuroendocrine tumor30.0KRT20, CDX2, SYP, NKX2-1
33fibrosarcoma30.0ACTC1, CA9
34seminoma30.0KRT18, CGB, CALB2
35pneumonia30.0MME
36cervical cancer30.0TP53, KRT10, KRT18, CA9
37neuroendocrine carcinoma29.9KRT20, KRT7, KRT18, CDX2, SYP, NKX2-1
38cervical adenocarcinoma29.9KRT20, KRT7, CDX2, MUC5AC, MUC16, CALB2
39endometrial carcinoma29.9TP53, MME, MUC16, NRAS, CSF1
40ovarian cancer29.9TP53, KRT7, KRT18, MME, MUC16, NRAS
41mature teratoma11.2
42ovarian cystic teratoma11.0
43mature teratoma of the ovary11.0
44malignant teratoma10.9
45mediastinum teratoma10.6
46mediastinitis10.6
47ovary adenocarcinoma10.6
48adult cystic teratoma10.5
49fallopian tube teratoma10.5
50ovarian squamous cell carcinoma10.5

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to cystic teratoma

Clinical Features for Cystic Teratoma

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Drugs & Therapeutics for Cystic Teratoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cystic Teratoma

Drug clinical trials:

Search ClinicalTrials for Cystic Teratoma

Search NIH Clinical Center for Cystic Teratoma

Search CenterWatch for Cystic Teratoma

Genetic Tests for Cystic Teratoma

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Anatomical Context for Cystic Teratoma

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32MalaCards
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MalaCards organs/tissues related to Cystic Teratoma:

32
Ovary, Pancreas, Thyroid, Liver, Testis, Colon, Lung, Prostate, Appendix, Skin, Pituitary, Breast, Adrenal gland, Uterus, Small intestine, Salivary gland, Cervix, Testes, Heart, Cerebellum, Thymus, Kidney, Brain, Pineal, Lymph node

Animal Models for Cystic Teratoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystic Teratoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5TP53, KRT10, CDX2, MUC2, NRAS, NKX2-1
2MP:00053818.8TP53, CA9, NKX2-1, NRAS, MUC2, MUC5AC

Publications for Cystic Teratoma

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50PubMed
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Articles related to Cystic Teratoma:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Appendix and uterus metastasis of squamous cell carcinoma arising from mature cystic teratoma of the ovary. (23840988)
2013
2
Mature (benign) cystic retroperitoneal teratoma involving the left adrenal gland in a 22-year-old male: a case report and literature review. (23762690)
2013
3
Vaginal-type tubulo-squamous polyp arising in mature cystic teratoma of the ovary. (23370649)
2013
4
Recurrence of mature cystic teratoma at a site of incision. (22779980)
2012
5
Mature cystic teratoma of the lung. (23192513)
2012
6
Squamous cell carcinoma arising in a mature cystic teratoma. (23320213)
2012
7
Conservative surgery in the management of a benign ovarian cystic teratoma presenting as a rectal mass: a case report. (21943447)
2011
8
Squamous cell carcinoma arising from mature cystic teratoma of the ovary. (21430455)
2011
9
Meningothelial proliferations in mature cystic teratoma of the ovary: evidence for the common presence of cranially derived tissues paralleling anterior embryonic plate development. An analysis of 25 consecutive cases. (20534997)
2010
10
Bilateral interruption of mid-fallopian tubes and ovarian anomalies including ectopic ovary and cystic teratoma, a previously unreported combination. (20621016)
2010
11
Mature cystic teratoma in the posterior mediastinum. (19503655)
2009
12
Benign cystic teratoma of mediastinum. (23133073)
2008
13
Cystic sacrococcygeal teratoma. (18528246)
2008
14
Mature cystic teratoma of the ovary with male accessory sexual glands including seminal vesicles, prostatic tissue, and bulbo-urethral glands: a case report. (18066589)
2008
15
Prognosis and treatment of squamous cell carcinoma from a mature cystic teratoma of the ovary. (18971155)
2008
16
Mature cystic teratoma in the falciform ligament of the liver. (17244973)
2007
17
Collision of invasive serous adenocarcinoma and mature cystic teratoma in the ovary. Letter to the editor. (17550386)
2007
18
A case of type III cystic sacrococcygeal teratoma. (16714864)
2006
19
A case of a mature cystic teratoma of the uterosacral ligament successfully treated by laparoscopic surgery. (15904595)
2005
20
Benign cystic teratoma of ovary perforating into small intestine with co-existent typhoid fever. (16361767)
2005
21
Case of mature cystic teratoma of the greater omentum misdiagnosed as ovarian cyst. (16176507)
2005
22
Mature ovarian cystic teratoma with a highly differentiated homunculus: a case report. (14745894)
2004
23
Gastrointestinal adenocarcinoma arising in a mature cystic teratoma of the ovary. (15297213)
2004
24
Large, complex, benign cystic teratoma in an adolescent. (12002202)
2002
25
Heterotopic omental ossification in response to spilled contents of a mature cystic teratoma: an unusual reaction. (12460211)
2002
26
Oligodendroglioma arising within a mature cystic ovarian teratoma: case report and review of the literature. (12225310)
2002
27
Benign cystic teratoma of the douglas. (11074146)
2000
28
Postpartum spontaneous rupture of a benign cystic teratoma. (15512620)
2000
29
Benign cystic teratoma of the lesser omentum. (9934783)
1999
30
Coexistent cystic teratoma of the omentum and ovary: report of two cases. (9233891)
1997
31
Benign cystic teratoma simulating organized empyema. (9141117)
1997
32
US case of the day. Benign cystic teratoma and testicular microlithiasis. (9153714)
1997
33
Sonography of benign cystic teratoma of the ovary: pitfalls in diagnosis. (8911163)
1996
34
Malignant degeneration of a mature cystic teratoma five decades after discovery. (8522269)
1995
35
Transvaginal ultrasonography in the diagnosis of cystic teratoma. (7800323)
1995
36
Intramedullary spinal cystic teratoma of the conus medullaris with caudal exophytic development: case report. (8115946)
1994
37
Case of the day. Benign cystic teratoma (dermoid cyst) of the left ovary. (8497038)
1993
38
Benign cystic teratoma of the testis. (2090686)
1990
39
SEM contribution to the morphological study of dental structures in ovarian cystic teratoma. (2269940)
1990
40
Ovarian mucinous cystadenocarcinoma of low malignant potential associated with a mature cystic teratoma. (3338676)
1988
41
Nuclear magnetic resonance imaging of a benign cystic teratoma in the retroperitoneum. (3795345)
1987
42
Cystic sacrococcygeal teratoma: ultrasound diagnosis and perinatal management. (3323552)
1987
43
Ovarian cystic teratoma as a cause of obstructed labour. (3665887)
1987
44
Schistosomiasis in a cystic teratoma of the ovary. (3102128)
1987
45
Malignant lymphoma arising within thyroid tissue in a mature cystic teratoma. (3768840)
1986
46
A cystic teratoma in skin. (3842792)
1985
47
Benign cystic teratoma of the ovary: a 6-year review. (4027793)
1985
48
Benign cystic teratoma (dermoid) of the testis. A case report. (3835117)
1985
49
Primary ovarian pregnancy in a cystic teratoma. (6472750)
1984
50
Squamous cell carcinoma in situ arising in adult cystic teratoma of the ovary. (5009017)
1972

Genetic Variations for Cystic Teratoma

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Expression for genes affiliated with Cystic Teratoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for genes affiliated with Cystic Teratoma

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12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 53Reactome
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Pathways related to Cystic Teratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TP53, CDX2, CGB
29.9MME, CD1A, CSF1
39.7KRT18, KRT7, KRT10, ACTC1
4
Hide members
9.7MUC5AC, MUC16, MUC2

Compounds for genes affiliated with Cystic Teratoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Cystic Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CALB2
2sialic acid4410.4KRT7
3reticulin4410.2SYP, KRT7, ACTC1
4dutp4410.2TP53, KRT10, KRT18, SYP
5crcs4410.1MME, TP53, MUC2
6h2o2449.9MUC16, MME, SYP
7sodium arsenite449.9DUSP19, TP53, KRT18
8butyrate449.9CALB2, DUSP19, CSF1, CDX2
95-aza-2deoxycytidine449.9CA9, TP53, KRT7, CDX2, MUC2
10methylcellulose449.9KRT18, CSF1, KRT10
11cytarabine44 49 1111.8CSF1, DUSP19, MME, TP53
125fluorouracil449.8KRT18, MUC2, TP53, MUC5AC, CSF1
13cyclophosphamide44 49 1111.7KRT18, TP53, CSF1, CGB, MUC16
14acetylcholine44 49 28 11 2413.7SYP, CALB2, DUSP19, MME
15actinomycin d449.7TP53, MUC2, KRT18, MME, CSF1
16ribonucleic acid449.6ACTC1, KRT20, NKX2-1, MME, MUC5AC
17formaldehyde44 2410.6SYP, KRT18, KRT7, KRT20, ACTC1, NKX2-1
18dmso449.6CSF1, DUSP19, MUC5AC, KRT18, MUC2
19matrigel449.6KRT18, CGB, MME, CSF1, KRT7, ACTC1
20retinoid449.6CSF1, MUC5AC, KRT7, KRT10, TP53, KRT18
21mucicarmine449.6KRT7, ACTC1, KRT20, NKX2-1, CALB2, SYP
22n acetylcysteine449.6KRT18, MUC5AC, TP53, CSF1, DUSP19
23thymidine44 2410.6CDX2, KRT18, TP53, CSF1, CALB2, MME
24forskolin44 49 1111.5NKX2-1, SYP, DUSP19, MUC2, MME, KRT18
25proline449.5MUC2, KRT10, TP53, MUC5AC, CA9
26glycogen44 2410.5ACTC1, CSF1, SYP, DUSP19, KRT18, KRT7
27oligonucleotide449.5NKX2-1, NRAS, MUC2, MUC5AC, CDX2, TP53
28chloride449.5MME, CSF1, CA9, MUC5AC
29paclitaxel44 49 1111.4MUC16, CSF1, DUSP19, CALB2, TP53
30cisplatin44 49 59 1112.4TP53, CSF1, MUC16, DUSP19, SYP, CGB
31lactate449.3MUC16, MME, KRT18, CSF1, CA9, CGB
32creatinine449.3ACTC1, KRT18, MME, MUC16, CGB, SYP
33b 723449.2NKX2-1, MUC16, KRT7, KRT20, CALB2, ACTC1
34doxorubicin44 49 1111.2CSF1, DUSP19, MME, KRT18, KRT20, TP53
35iron44 2410.2KRT7, ACTC1, MUC16, KRT18, KRT20
36dopamine44 28 11 2412.1KRT18, MME, DUSP19, CALB2
37dexamethasone44 49 28 1112.1DUSP19, NKX2-1, KRT18, MUC2, MUC16, MME
38threonine449.1KRT18, KRT10, MUC16, MUC2, DUSP19, NKX2-1
39cysteine449.1CDX2, MME, CGB, SYP, DUSP19, MUC2
40glucose449.0CA9, KRT7, MUC5AC, MUC16, MUC2, ACTC1
41steroid448.7NKX2-1, SYP, MUC5AC, CDX2, MUC16, KRT10
42calcium44 49 11 2411.5CALB2, DUSP19, CDX2, MME, SYP, ACTC1
43vegf448.4ACTC1, MME, MUC16, KRT7, KRT20, CA9
44serine448.4MUC2, KRT10, KRT18, TP53, DUSP19, SYP
45hematoxylin448.4SYP, MUC2, CALB2, KRT7, MUC16, MUC5AC
46retinoic acid44 249.3TP53, ACTC1, KRT18, CSF1, MME, MUC5AC
47testosterone44 59 11 2411.3KRT18, KRT7, CALB2, CGB, SYP, MUC16
48paraffin447.4MUC16, TP53, ACTC1, KRT10, KRT20, KRT7
49progesterone44 59 28 11 2411.2TP53, KRT7, ACTC1, KRT10, KRT20, CALB2
50tyrosine447.2NRAS, SYP, NKX2-1, CSF1, CA9, CALB2

GO Terms for genes affiliated with Cystic Teratoma

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16Gene Ontology
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Cellular components related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:04430610.0MME, SYP
2keratin filamentGO:0450959.9KRT10, KRT7, KRT18
3intermediate filamentGO:0058829.6KRT10, KRT20, KRT7, KRT18
4Golgi lumenGO:0057969.4MUC2, MUC16, MUC5AC

Biological processes related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.1TP53, MME
2O-glycan processingGO:0162669.6MUC5AC, MUC16, MUC2
3cellular protein metabolic processGO:0442678.9CGB, MUC2, MUC16, MUC5AC, MME

Products for genes affiliated with Cystic Teratoma

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Sources for Cystic Teratoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet