MCID: CYS017
MIFTS: 40

Cystic Teratoma malady

Categories: Cancer diseases

Aliases & Classifications for Cystic Teratoma

Aliases & Descriptions for Cystic Teratoma:

Name: Cystic Teratoma 12 14 69
Benign Teratoma 69
Dermoid Cyst 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2660
NCIt 47 C9014
SNOMED-CT 64 42717009
UMLS 69 C1368903

Summaries for Cystic Teratoma

MalaCards based summary : Cystic Teratoma, also known as benign teratoma, is related to neuroendocrine tumor and ovarian squamous cell carcinoma. An important gene associated with Cystic Teratoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Inhibition of Ribosome Biogenesis by p14(ARF) and TP53 Network. The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and liver, and related phenotypes are cardiovascular system and cellular

Related Diseases for Cystic Teratoma

Diseases in the Cystic Teratoma family:

Adult Cystic Teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
id Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 29.9 CDX2 KRT20
2 ovarian squamous cell carcinoma 29.7 KRT20 MUC6
3 apocrine adenocarcinoma 29.7 CDX2 KRT20 KRT7
4 central neurocytoma 29.5 GFAP SYP
5 struma ovarii 29.0 KRT20 KRT7 MUC2 MUC6 SYP
6 ovarian cystic teratoma 12.1
7 adult cystic teratoma 12.1
8 dermoid cyst 11.2
9 teratoma 11.0
10 squamous cell carcinoma 10.5
11 adenocarcinoma 10.4
12 radiculopathy 10.3 KRT20 KRT7
13 adult myxoid chondrosarcoma 10.3 KRT20 KRT7
14 clitoris cancer 10.3 CDX2 KRT20
15 bronchus mucoepidermoid carcinoma 10.3 KRT20 KRT7
16 chromophil adenoma of the kidney 10.3 KRT20 NKX2-1
17 steroid-induced glaucoma - borderline 10.3 KRT20 KRT7
18 extramedullary plasmacytoma 10.3 CDX2 KRT20
19 uterine ligament mucinous adenocarcinoma 10.3 CDX2 KRT7
20 waterhouse-friderichsen syndrome 10.3 KRT20 KRT7
21 villous adenocarcinoma 10.3 NKX2-1 SYP
22 peripheral nervous system ganglioneuroblastoma 10.3 CDX2 KRT7
23 small intestine leiomyoma 10.3 KRT20 TP53
24 clear cell hidradenoma 10.3 KRT20 TP53
25 spiradenoma 10.3 KRT20 TP53
26 tmem70 defect 10.3 NKX2-1 TP53
27 suppurative lymphadenitis 10.2 CDKN2A KRT7
28 sclerosing breast papilloma 10.2 KRT7 TP53
29 clear cell adenofibroma 10.2 CDKN2A TP53
30 main bronchus cancer 10.2 KRT7 SYP
31 degenerative myopia 10.2 KRT20 KRT7
32 lacrimal gland adenoid cystic carcinoma 10.2 CDKN2A TP53
33 peritoneal benign neoplasm 10.2 CDX2 KRT20 KRT7
34 dystonia 10.2 CDX2 KRT20 KRT7
35 anal canal paget's disease 10.2 CDX2 KRT20 KRT7
36 perineural angioma 10.2 SYP TP53
37 melanoma 10.2
38 pericardium leiomyoma 10.2 CDKN2A TP53
39 mucosal melanoma 10.2 CDX2 KRT20 KRT7
40 agenesis and aplasia of uterine body 10.2 KRT20 KRT7 NKX2-1
41 churg-strauss syndrome 10.2 CDX2 KRT20 KRT7
42 diabetes hypogonadism deafness mental retardation 10.2 GFAP SYP
43 papillary tumor of the pineal region 10.2 GFAP SYP
44 brain stem ependymoma 10.2 GFAP SYP
45 spondylarthropathy 10.2 CDKN2A TP53
46 ariboflavinosis 10.2 CDX2 KRT20 KRT7
47 intrahepatic bile duct adenoma 10.2 GFAP SYP
48 pilocytic astrocytoma of cerebellum 10.2 GFAP SYP
49 choroid epithelioid cell melanoma 10.2 CDX2 MUC2
50 liver fibrosarcoma 10.2 GFAP TP53

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to Cystic Teratoma

Symptoms & Phenotypes for Cystic Teratoma

MGI Mouse Phenotypes related to Cystic Teratoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CDKN2A CDX2 GFAP KIT MUC2 NKX2-1
2 cellular MP:0005384 9.76 CDKN2A CDX2 GFAP KIT KRT7 MUC2
3 digestive/alimentary MP:0005381 9.5 CDKN2A CDX2 GFAP KIT MUC2 NKX2-1
4 neoplasm MP:0002006 9.1 CDKN2A CDX2 KIT MUC2 NKX2-1 TP53

Drugs & Therapeutics for Cystic Teratoma

Drugs for Cystic Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Bleomycin Approved Phase 3,Phase 2 11056-06-7 5360373
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
7
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
8
Lenograstim Approved Phase 2, Phase 3,Phase 1 135968-09-1
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Captopril Approved Phase 3 62571-86-2 44093
11
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Fluconazole Approved Phase 3 86386-73-4 3365
14
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
15
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
16
Palivizumab Approved, Investigational Phase 3 188039-54-5
17
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
18
Vinblastine Approved Phase 3 865-21-4 13342 241903
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Hormone Antagonists Phase 3,Phase 2,Phase 1
23 Hormones Phase 3,Phase 2,Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
25 Anti-Bacterial Agents Phase 3,Phase 2
26 Etoposide phosphate Phase 3,Phase 2,Phase 1
27 Isophosphamide mustard Phase 3,Phase 2,Phase 1
28 Antibiotics, Antitubercular Phase 3,Phase 2
29 Antimitotic Agents Phase 3,Phase 2,Phase 1
30 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
31 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
32 Hydroxyitraconazole Phase 3
33
protease inhibitors Phase 3
34 Steroid Synthesis Inhibitors Phase 3
35 HIV Protease Inhibitors Phase 3
36 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
37 Cytochrome P-450 CYP3A Inhibitors Phase 3
38 Cytochrome P-450 Enzyme Inhibitors Phase 3
39 Echinocandins Phase 3
40 Angiotensin-Converting Enzyme Inhibitors Phase 3
41 Immunoglobulins Phase 3,Phase 2,Phase 1
42 Anti-Infective Agents Phase 3,Phase 2
43 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
44 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
45 Antifungal Agents Phase 3
46 Antihypertensive Agents Phase 3
47 Antimetabolites Phase 3
48 Liposomal amphotericin B Phase 3
49 Antibodies Phase 3,Phase 2,Phase 1
50 Antirheumatic Agents Phase 3

Interventional clinical trials:

(show all 38)
id Name Status NCT ID Phase
1 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3
4 Single-port LC Might be Preferable for Managing Ovarian Dermoid Cyst. Completed NCT02009228 Phase 3
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
6 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
7 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
9 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
10 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3
11 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2
12 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2
13 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2
14 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2
15 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2
16 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
17 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
18 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
19 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
20 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2
21 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2
22 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2
23 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2
24 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2
25 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
26 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2
27 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
28 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1
29 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
30 Laser Tissue Welding - Distal Pancreatectomy Sealing Study Recruiting NCT03147768 Phase 1
31 Ovarian Mesial Incision: a New Safe and Fertility-sparing Technique Completed NCT01590030
32 Anterior Mediastinum Teratoma: A Case Report Completed NCT00836121
33 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
34 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465
35 Epidural and Spinal Anesthesia Techniques in Pilonidal Dermoid Sinus Surgeries Recruiting NCT02580500
36 Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis Recruiting NCT03020108
37 Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK) Recruiting NCT02224677
38 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Active, not recruiting NCT01080521

Search NIH Clinical Center for Cystic Teratoma

Genetic Tests for Cystic Teratoma

Anatomical Context for Cystic Teratoma

MalaCards organs/tissues related to Cystic Teratoma:

39
Ovary, Pancreas, Liver, Colon, Thyroid, Prostate, Testis

Publications for Cystic Teratoma

Articles related to Cystic Teratoma:

(show top 50) (show all 621)
id Title Authors Year
1
Metastatic Mucinous Adenocarcinoma and Carcinoid Tumor Arising From a Mature Cystic Teratoma of a Horseshoe Kidney. ( 28083486 )
2017
2
An ovarian mature cystic teratoma evolving in squamous cell carcinoma: A case report and review of the literature. ( 28050596 )
2017
3
Upper Lumbar Mature Cystic Teratoma: A Case Report. ( 27641261 )
2016
4
Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary. ( 27987343 )
2016
5
Mature Cystic Teratoma of the Ovary With Three Kinds of Entire Gastrointestinal Wall and Complete Bronchial Structure in a Pregnant Woman. ( 27098586 )
2016
6
Radiotherapy for persistent malignant transformation from mature cystic teratoma of the ovary. ( 26889642 )
2016
7
Autoamputation of an ovarian mature cystic teratoma: a case report and a review of the literature. ( 27535361 )
2016
8
Mature Cystic Teratoma of Ovary with Abnormally High Levels of Ca19-9: A Case Report. ( 27434195 )
2016
9
Giant intra-abdominal mature cystic teratoma (dermoid cyst) in an adult male, with male genitourinary tissue including prostatic and penile elements. ( 27038684 )
2016
10
Mature cystic teratoma of mediastinum with pleural effusion: An uncommon entity. ( 27098949 )
2016
11
Squamous Cell Carcinoma Arising in Background of Mature Cystic Teratoma. ( 27981940 )
2016
12
A rare case of microinvasive squamous cell carcinoma arising in mature cystic teratoma of the ovary. ( 27352578 )
2016
13
Port-site metastasis after laparoscopic surgery for mature cystic teratoma. ( 27172754 )
2016
14
Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. ( 26980033 )
2016
15
Whole-exome sequencing identified the genetic origin of a mucinous neoplasm in a mature cystic teratoma. ( 27114374 )
2016
16
Ovarian mature cystic teratoma with fistula formation into the rectum: a case report. ( 27757372 )
2016
17
Follicular Lymphoma Arising In a Mature Cystic Teratoma in a 26 Year Old Female. ( 27312556 )
2016
18
Mature Cystic Teratoma of the Pancreas. ( 26958551 )
2016
19
Diagnosis of Cystic Teratoma Facilitated by Point-of-Care Ultrasonography. ( 27490733 )
2016
20
Torsed Meckel Diverticulum Mimicking a Cystic Teratoma. ( 27380610 )
2016
21
Cystic teratoma mimicking recurrent pleural effusion, complicated by Mycobacterium abscessus infection. ( 27516884 )
2016
22
Retroperitoneal Mature Cystic Teratoma in a Neonate: A Case Report. ( 27123399 )
2016
23
Synchronous occurrence of mature cystic teratoma of the fallopian tube and ovary: A case report. ( 27446368 )
2016
24
A carcinoid tumor arising from a mature cystic teratoma in a 25-year-old patient: a case study. ( 27098182 )
2016
25
Advanced Mucinous Adenocarcinoma Arising from a Mature Cystic Teratoma: A Case Report and Literature Review. ( 27462234 )
2016
26
An Ovarian Mature Cystic Teratoma With Colon Involvement. ( 27924086 )
2016
27
Granular Cell Tumor Within an Ovarian Mature Cystic Teratoma: Report of a Unique Case and Review of the Literature. ( 27750257 )
2016
28
Primary Primitive Neuroectodermal Tumor Arising from an Ovarian Mature Cystic Teratoma in a 12-Year-Old Girl: A Case Report. ( 27919713 )
2016
29
Large Mature Cystic Teratoma of the Third Ventricle in Infancy: A Case Report and Review of Literatures. ( 27195263 )
2016
30
Primary retroperitoneal mature cystic teratoma in an adult: A case report. ( 27769025 )
2016
31
A Giant Mature Cystic Teratoma Mimicking a Pleural Effusion. ( 26942032 )
2016
32
Primary mature cystic teratoma with carcinoid mimicking an adrenal tumor: Report of a rare association and review of literature. ( 27166041 )
2016
33
Spinal intramedullary mature cystic teratoma in an adult. ( 26759928 )
2016
34
Ectopic prostatic tissue in mature cystic teratoma of the ovary, a case report and review of the literature. ( 26757698 )
2016
35
Intestinal-Type Adenocarcinoma Arising in a Mature Cystic Teratoma of the Ovary. ( 26937866 )
2016
36
Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: a case report. ( 27793140 )
2016
37
Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: A case report. ( 27508272 )
2016
38
Expression and clinical significance of tumor markers in ovarian mature cystic teratoma. ( 27328499 )
2016
39
Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports. ( 26801904 )
2016
40
Ovarian Mature Cystic Teratoma: Challenges of Surgical Management. ( 27110246 )
2016
41
Ovarian Carcinosarcoma and Its Association with Mature Cystic Teratoma and Primary Tubal Carcinoma. ( 27807494 )
2016
42
Superior mediastinal mature cystic teratoma with gastrointestinal adenocarcinoma transformation: Report of a case. ( 27221036 )
2016
43
Oligodendroglial cell proliferation arising in an ovarian mature cystic teratoma. Clinicopathological, inmunohistochemical, and ultrastructural study of a case that may represent an oligodendroglioma. ( 28029275 )
2016
44
Urothelial carcinoma arising from an ovarian mature cystic teratoma. ( 26384067 )
2015
45
Carcinoid tumor arising in a mature cystic teratoma: A case report. ( 26137048 )
2015
46
A rare case of combined placental site trophoblastic tumour with mature cystic teratoma and mixed germ cell tumour in the testis. ( 26277672 )
2015
47
Squamous cell carcinoma arising in a mature cystic teratoma exposed through a colo-ovarian fistula. ( 25692501 )
2015
48
Choroid plexus papilloma arising in a mature cystic teratoma of the ovary: A short case report and literature review. ( 25913225 )
2015
49
Malignant transformation rate and p53, and p16 expression in teratomatous skin of ovarian mature cystic teratoma. ( 25735349 )
2015
50
Mature cystic teratoma of both the fallopian tube and contralateral ovary: a case report. ( 26753493 )
2015

Variations for Cystic Teratoma

Expression for Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for Cystic Teratoma

Pathways related to Cystic Teratoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.3 CDKN2A TP53
2
Show member pathways
9.97 CDKN2A TP53

GO Terms for Cystic Teratoma

Cellular components related to Cystic Teratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 GFAP KRT20 KRT7

Biological processes related to Cystic Teratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC6
2 replicative senescence GO:0090399 8.96 CDKN2A TP53
3 somatic stem cell division GO:0048103 8.62 CDKN2A KIT

Sources for Cystic Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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