MCID: CYS017
MIFTS: 48

Cystic Teratoma malady

Summaries for Cystic Teratoma

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MalaCards: Cystic Teratoma, also known as cystic teratoma, nos, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Cystic Teratoma is TP53 (tumor protein p53), and among its related pathways are Selected targets of Oct-3/4 and Hematopoietic cell lineage. The compounds estrogen and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and thyroid, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Cystic Teratoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

cystic teratoma 8 60
cystic teratoma, nos 8


External Ids:

Disease Ontology8 DOID:2660
SNOMED-CT56 42717009
NCIt39 C9014

Related Diseases for Cystic Teratoma

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17GeneCards, 18GeneDecks
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Diseases in the Cystic Teratoma family:

Adult Cystic Teratoma

Diseases related to Cystic Teratoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.2TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
2adenocarcinoma31.0TP53, ACTC1, KRT10, KRT20, KRT7, KRT18
3melanoma30.9TP53, ACTC1, KRT18, MME, CDX2, CD1A
4pseudomyxoma peritonei30.6KRT20, KRT7, CDX2, MUC5AC, MUC2
5cystadenocarcinoma30.5MUC5AC, MUC16, MUC2
6peritonitis30.5MUC16
7mucinous cystadenocarcinoma30.5KRT20, KRT7, MUC16
8pancreatitis30.3NRAS
9cystadenoma30.3KRT7, MME
10adenosquamous carcinoma30.3KRT20, KRT7, MUC5AC, MUC2, NKX2-1
11paraganglioma30.2SYP
12leiomyoma30.2ACTC1, MME
13papilloma30.2MUC5AC, MUC2
14angiosarcoma30.2ACTC1, KRT18, CALB2
15endodermal sinus tumor30.2KRT7, MUC16, CGB
16colon adenocarcinoma30.2KRT20, MUC5AC, MUC2, CALB2
17sarcoma30.2TP53, ACTC1, CD1A, NRAS, CGB, CSF1
18papillary carcinoma30.2ACTC1, KRT20, KRT7, KRT18, MUC16, MUC2
19adenoma30.2TP53, ACTC1, KRT20, KRT7, KRT18, CDX2
20breast cancer30.1TP53, KRT7, KRT18, MME, CDX2, CD1A
21leydig cell tumor30.0CALB2
22neuroblastoma30.0TP53, SYP
23sertoli-leydig cell tumor30.0KRT7, CALB2
24hemangioma30.0ACTC1, NKX2-1
25sertoli cell tumor30.0SYP, CALB2
26meningioma30.0SYP, CALB2
27chordoma30.0KRT7, KRT18
28rhabdomyosarcoma30.0TP53, ACTC1, CALB2
29hepatoblastoma30.0KRT7, KRT18
30struma ovarii30.0MUC16, NKX2-1
31large cell carcinoma30.0KRT20, KRT7, SYP, NKX2-1
32neuroendocrine tumor30.0KRT20, CDX2, SYP, NKX2-1
33fibrosarcoma30.0ACTC1, CA9
34seminoma30.0KRT18, CGB, CALB2
35pneumonia30.0MME
36cervical cancer30.0TP53, KRT10, KRT18, CA9
37neuroendocrine carcinoma29.9KRT20, KRT7, KRT18, CDX2, SYP, NKX2-1
38cervical adenocarcinoma29.9KRT20, KRT7, CDX2, MUC5AC, MUC16, CALB2
39endometrial carcinoma29.9TP53, MME, MUC16, NRAS, CSF1
40ovarian cancer29.9TP53, KRT7, KRT18, MME, MUC16, NRAS
41mature teratoma11.2
42ovarian cystic teratoma11.0
43mature teratoma of the ovary11.0
44malignant teratoma10.9
45mediastinum teratoma10.6
46mediastinitis10.6
47ovary adenocarcinoma10.6
48adult cystic teratoma10.5
49fallopian tube teratoma10.5
50ovarian squamous cell carcinoma10.5

Graphical network of the top 20 diseases related to Cystic Teratoma:



Diseases related to cystic teratoma

Clinical Features for Cystic Teratoma

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Drugs & Therapeutics for Cystic Teratoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Cystic Teratoma

Drug clinical trials:

Search ClinicalTrials for Cystic Teratoma

Search NIH Clinical Center for Cystic Teratoma

Search CenterWatch for Cystic Teratoma

Genetic Tests for Cystic Teratoma

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Anatomical Context for Cystic Teratoma

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32MalaCards
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MalaCards organs/tissues related to Cystic Teratoma:

32
Ovary, Pancreas, Thyroid, Liver, Testis, Colon, Prostate, Lung, Skin, Appendix, Adrenal gland, Breast, Pituitary, Small intestine, Uterus, Testes, Cervix, Pineal, Salivary gland, Kidney, Heart, Cerebellum, Brain, Thymus, Lymph node

Animal Models for Cystic Teratoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystic Teratoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5TP53, KRT10, CDX2, MUC2, NRAS, NKX2-1
2MP:00053818.8TP53, CA9, NKX2-1, NRAS, MUC2, MUC5AC

Publications for Cystic Teratoma

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50PubMed
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Articles related to Cystic Teratoma:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Giant mature adrenal cystic teratoma in an infant. (24058257)
2013
2
Central primary primitive neuroectodermal tumor (cPNET) arising from an ovarian mature cystic teratoma in pregnancy: A case report and review of medical literature. (24371678)
2013
3
Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy. (24327990)
2013
4
Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature. (23216975)
2012
5
Ovarian paraganglioma arising from mature cystic teratoma. (23018209)
2012
6
Mature cystic teratoma (dermoid cyst) in the sylvian fissure: a case report and review of the literature. (22190504)
2012
7
Mature cystic teratoma of the pancreas. Case report and review of the literature of a rare pancreatic cystic lesion. (22233950)
2012
8
Adenocarcinoma with sarcomatous dedifferentiation arising from mature cystic teratoma of the anterior mediastinum. (23089288)
2012
9
Case of the month. Mature cystic teratoma. (22514964)
2012
10
Origin of uterine teratoma differs from that of ovarian teratoma: a case of uterine mature cystic teratoma. (21979590)
2011
11
Trichoadenoma in a mature cystic teratoma: a rare finding. (21177212)
2011
12
A case of thyroid-type papillary carcinoma derived from ovarian mature cystic teratoma, resected by laparoscopic surgery. (22776228)
2011
13
Papillary thyroid carcinoma arising from mature cystic teratoma of the ovary. (21126146)
2010
14
Mature cystic teratoma of the liver in an adult female. (21045458)
2010
15
Cystic seminoma with elevated value of carbohydrate antigen 19-9 in tumor fluid mimicking cystic teratoma. (19853145)
2009
16
Enterovascular fistula in a patient with squamous cell carcinoma arising in a cystic teratoma. (19373163)
2009
17
Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins. (19067849)
2008
18
Severe chemical peritonitis caused by spontaneous rupture of an ovarian mature cystic teratoma: a case report. (17977177)
2007
19
Chylopericardium presenting as cardiac tamponade secondary to an anterior mediastinal cystic teratoma. (17948094)
2007
20
Adnexal torsion of mature cystic teratoma with hemorrhagic infarction: helpful findings on successive plain abdominal radiographs. (17541518)
2007
21
Floating ball appearance in ovarian cystic teratoma. (16972218)
2006
22
Benign cystic teratoma mimicking an abdominal pregnancy. (17091424)
2006
23
Prenatal diagnosis of a cystic type IV sacrococcygeal teratoma mimicking a cloacal anomaly: contribution of MR. (15791662)
2005
24
Mucinous adenocarcinoma arising from one retroperitoneal mature cystic teratoma in a postmenopausal woman. (15771638)
2005
25
Cystic teratoma of the pancreas: a case report. (15307462)
2004
26
Mature cystic teratoma of the pancreas in a child. (12709759)
2003
27
Undifferentiated carcinoma with osteoclast-like multinucleated giant cells arising in an ovarian mature cystic teratoma. (14566099)
2003
28
Large benign cystic teratoma of the mesosigmoid causing intestinal obstruction: report of a case. (12376796)
2002
29
Benign cystic teratoma of the omentum. (11906429)
2002
30
Analysis of 20 mature ovarian cystic teratoma cases in postmenopausal women. (11780192)
2001
31
Multiple mobile spherules in mature cystic teratoma of the ovary. (11373213)
2001
32
Conservative management of ovarian cystic teratoma during pregnancy and labor. (10739498)
2000
33
Prostatic tissue in a benign cystic teratoma of the ovary. Report of two cases. (11344736)
2000
34
Ectopic pituitary with pregnancy changes in a benign cystic teratoma of the ovary. (10643021)
1999
35
Adenosquamous carcinoma and schneiderian papilloma-like lesion in a mature cystic teratoma of the ovary: a case report. (8768388)
1996
36
Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. (8886884)
1996
37
Clinical evaluation of squamous cell carcinoma antigen in squamous cell carcinoma arising in mature cystic teratoma of the ovary. (7777241)
1995
38
CA19-9 in mature cystic teratoma. (8073424)
1994
39
Well-differentiated adenocarcinoma arising from mature cystic teratoma of the mediastinum (teratoma with malignant transformation). Report of a surgical case. (8160647)
1994
40
Radiology of retroperitoneal cystic teratoma in adult: a case report. (7869011)
1994
41
Squamous cell carcinoma in situ arising in an ovarian mature cystic teratoma. Report of one case with histopathologic, cytogenetic, and flow cytometric DNA content analysis. (1992986)
1991
42
Elevated serum tumor markers in patients with testicular cancer after induction chemotherapy due to a reservoir of markers in cystic differentiated mature teratoma. (1706441)
1991
43
Paget's disease and invasive undifferentiated carcinoma occurring in a mature cystic teratoma of the ovary. (1653182)
1991
44
Benign cystic teratoma of the parotid salivary gland: report of the first case in Thailand. (1797960)
1991
45
A young woman with vague lower abdominal pain. Benign cystic teratoma (dermoid cyst). (2735042)
1989
46
Multiple neuroectodermal tumors arising in a mature cystic teratoma of the ovary. (2753429)
1989
47
Endodermal sinus tumor and benign cystic teratoma of the ovary occurring simultaneously. (2733880)
1989
48
Cystic teratoma of the mesentery. (2671899)
1989
49
Benign cystic teratoma of ovary containing a homunculus. (4020199)
1985
50
Sebaceous carcinoma arising in benign cystic teratoma of the ovary. Case report. (6723706)
1984

Genetic Variations for Cystic Teratoma

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Expression for genes affiliated with Cystic Teratoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystic Teratoma

Search GEO for disease gene expression data for Cystic Teratoma.

Pathways for genes affiliated with Cystic Teratoma

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12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 53Reactome
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Pathways related to Cystic Teratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0TP53, CDX2, CGB
29.9MME, CD1A, CSF1
39.7KRT18, KRT7, KRT10, ACTC1
4
Hide members
9.7MUC5AC, MUC16, MUC2

Compounds for genes affiliated with Cystic Teratoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Cystic Teratoma according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CALB2
2sialic acid4410.4KRT7
3reticulin4410.2SYP, KRT7, ACTC1
4dutp4410.2TP53, KRT10, KRT18, SYP
5crcs4410.1MME, TP53, MUC2
6h2o2449.9MUC16, MME, SYP
7sodium arsenite449.9DUSP19, TP53, KRT18
8butyrate449.9CALB2, DUSP19, CSF1, CDX2
95-aza-2deoxycytidine449.9CA9, TP53, KRT7, CDX2, MUC2
10methylcellulose449.9KRT18, CSF1, KRT10
11cytarabine44 49 1111.8CSF1, DUSP19, MME, TP53
125fluorouracil449.8KRT18, MUC2, TP53, MUC5AC, CSF1
13cyclophosphamide44 49 1111.7KRT18, TP53, CSF1, CGB, MUC16
14acetylcholine44 49 28 11 2413.7SYP, CALB2, DUSP19, MME
15actinomycin d449.7TP53, MUC2, KRT18, MME, CSF1
16ribonucleic acid449.6ACTC1, KRT20, NKX2-1, MME, MUC5AC
17formaldehyde44 2410.6SYP, KRT18, KRT7, KRT20, ACTC1, NKX2-1
18dmso449.6CSF1, DUSP19, MUC5AC, KRT18, MUC2
19matrigel449.6KRT18, CGB, MME, CSF1, KRT7, ACTC1
20retinoid449.6CSF1, MUC5AC, KRT7, KRT10, TP53, KRT18
21mucicarmine449.6KRT7, ACTC1, KRT20, NKX2-1, CALB2, SYP
22n acetylcysteine449.6KRT18, MUC5AC, TP53, CSF1, DUSP19
23thymidine44 2410.6CDX2, KRT18, TP53, CSF1, CALB2, MME
24forskolin44 49 1111.5NKX2-1, SYP, DUSP19, MUC2, MME, KRT18
25proline449.5MUC2, KRT10, TP53, MUC5AC, CA9
26glycogen44 2410.5ACTC1, CSF1, SYP, DUSP19, KRT18, KRT7
27oligonucleotide449.5NKX2-1, NRAS, MUC2, MUC5AC, CDX2, TP53
28chloride449.5MME, CSF1, CA9, MUC5AC
29paclitaxel44 49 1111.4MUC16, CSF1, DUSP19, CALB2, TP53
30cisplatin44 49 59 1112.4TP53, CSF1, MUC16, DUSP19, SYP, CGB
31lactate449.3MUC16, MME, KRT18, CSF1, CA9, CGB
32creatinine449.3ACTC1, KRT18, MME, MUC16, CGB, SYP
33b 723449.2NKX2-1, MUC16, KRT7, KRT20, CALB2, ACTC1
34doxorubicin44 49 1111.2CSF1, DUSP19, MME, KRT18, KRT20, TP53
35iron44 2410.2KRT7, ACTC1, MUC16, KRT18, KRT20
36dopamine44 28 11 2412.1KRT18, MME, DUSP19, CALB2
37dexamethasone44 49 28 1112.1DUSP19, NKX2-1, KRT18, MUC2, MUC16, MME
38threonine449.1KRT18, KRT10, MUC16, MUC2, DUSP19, NKX2-1
39cysteine449.1CDX2, MME, CGB, SYP, DUSP19, MUC2
40glucose449.0CA9, KRT7, MUC5AC, MUC16, MUC2, ACTC1
41steroid448.7NKX2-1, SYP, MUC5AC, CDX2, MUC16, KRT10
42calcium44 49 11 2411.5CALB2, DUSP19, CDX2, MME, SYP, ACTC1
43vegf448.4ACTC1, MME, MUC16, KRT7, KRT20, CA9
44serine448.4MUC2, KRT10, KRT18, TP53, DUSP19, SYP
45hematoxylin448.4SYP, MUC2, CALB2, KRT7, MUC16, MUC5AC
46retinoic acid44 249.3TP53, ACTC1, KRT18, CSF1, MME, MUC5AC
47testosterone44 59 11 2411.3KRT18, KRT7, CALB2, CGB, SYP, MUC16
48paraffin447.4MUC16, TP53, ACTC1, KRT10, KRT20, KRT7
49progesterone44 59 28 11 2411.2TP53, KRT7, ACTC1, KRT10, KRT20, CALB2
50tyrosine447.2NRAS, SYP, NKX2-1, CSF1, CA9, CALB2

GO Terms for genes affiliated with Cystic Teratoma

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16Gene Ontology
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Cellular components related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection terminusGO:04430610.0MME, SYP
2keratin filamentGO:0450959.9KRT10, KRT7, KRT18
3intermediate filamentGO:0058829.6KRT10, KRT20, KRT7, KRT18
4Golgi lumenGO:0057969.4MUC2, MUC16, MUC5AC

Biological processes related to Cystic Teratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:09039910.1TP53, MME
2O-glycan processingGO:0162669.6MUC5AC, MUC16, MUC2
3cellular protein metabolic processGO:0442678.9CGB, MUC2, MUC16, MUC5AC, MME

Products for genes affiliated with Cystic Teratoma

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Sources for Cystic Teratoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet