PORK
MCID: CYS005
MIFTS: 64

Cysticercosis (PORK) malady

Infectious diseases, Gastrointestinal diseases, Neuronal diseases categories

Summaries for Cysticercosis

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8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards: Cysticercosis, also known as neurocysticercosis, is related to echinococcosis and hyperglycemia. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Leishmaniasis and Malaria. The drugs albendazole and praziquantel and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are no phenotypic analysis and cellular.

Disease Ontology:8 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:3 Cysticercosis is a parasitic tissue infection caused by larval cysts of the pork tapeworm. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. An individual acquires cysticercosis from ingesting eggs excreted by a person who has an intestinal tapeworm. People living in the same household with a tapeworm carrier have a much higher risk of getting cysticercosis than others.

Wikipedia:63 Cysticercosis is a tissue infection by the pork tapeworm (Taenia solium). People may have little or no... more...

Aliases & Classifications for Cysticercosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
cysticercosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

cysticercosis 8 42 10 44 48 60
neurocysticercosis 8 42 44 60
submacular cysticercosis 42 60
tapeworm infection: intestinal taenia solium 8
intestinal taenia solium infection 8
tenia solium infectious disease 8
pork tapeworm infection 8
taeniasis 42
pork 8


External Ids:

Disease Ontology8 DOID:10079
ICD9CM27 123.1
NCIt39 C34520
MeSH34 D003551
MESH via Orphanet35 D003551
SNOMED-CT via Orphanet57 105684008, 59051007
ICD10 via Orphanet26 B69.0, B69.1, B69.8 B69.9, more
UMLS via Orphanet61 C0010678
ICD1025 B69, B69.9

Related Diseases for Cysticercosis

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17GeneCards, 18GeneDecks
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Diseases related to Cysticercosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis30.8MT-CO1, STYX
2hyperglycemia30.7SLC5A2
3type 1 diabetes30.6STYX, IL10, IL4
4hepatitis30.0IL18
5adenocarcinoma30.0TACSTD2
6gastritis29.9MIF
7diabetes mellitus29.8TNF
8eclampsia29.8SPIN4
9hepatitis b29.8MIF
10schistosomiasis29.8IL4, IL10, IGHE
11tuberculosis29.7TNF, MIF, IL10, IL18, IL4
12taeniasis10.9
13type 1 diabetes mellitus10.6
14type 2 diabetes mellitus10.6
15maturity-onset diabetes of the young, type 110.6
16diabetic ketoacidosis10.5
17maturity-onset diabetes of the young10.5
18immunodysregulation, polyendocrinopathy and enteropathy x-linked10.5
19brittle diabetes10.5
20maturity-onset diabetes of the young, type 210.5
21maturity-onset diabetes of the young, type 610.5
22epiphyseal dysplasia multiple with early-onset diabetes mellitus10.5
23diabetes, type 210.5
24rh-mod syndrome10.5
25cerebritis10.4
26hepatitis e10.4
27toxocariasis10.3
28cervicitis10.2
29hydrocephalus10.2
30cranial nerve palsy10.1
31hypoglycemia10.1
32pseudotumor cerebri10.0
33lateral sinus thrombosis10.0
34eosinophilic meningitis10.0
35adenoma10.0
36pituitary adenoma10.0
37cystic echinococcosis10.0
38ascariasis10.0
39neuroretinitis10.0
40empty sella syndrome10.0
41onchocerciasis10.0
42fascioliasis10.0
43obstructive hydrocephalus10.0
44glaucoma10.0
45herpes simplex10.0DUT
46pancreatic cancer10.0TACSTD2
47glomerulonephritis10.0MIF
48hepatocellular carcinoma10.0ARG1
49acute myocardial infarction10.0MIF
50deficiency anemia10.0MIF

Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Clinical Features for Cysticercosis

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Drugs & Therapeutics for Cysticercosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cysticercosis

Drug clinical trials:

Search ClinicalTrials for Cysticercosis

Search NIH Clinical Center for Cysticercosis

Search CenterWatch for Cysticercosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cysticercosis

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Anatomical Context for Cysticercosis

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32MalaCards
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MalaCards organs/tissues related to Cysticercosis:

32
Brain, Testes, Eye, Heart, Skin, Tongue, Breast, Spinal cord, Kidney, Salivary gland, Liver, Thyroid, Spleen, Temporal lobe, Pancreas

Animal Models for Cysticercosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cysticercosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9SLC5A2, IGHE, PDCD1LG2
2MP:00053847.1MT-CO1, TNF, PDCD1LG2, SAFB, AGR2, MIF
3MP:00053876.7PDCD1LG2, TNF, ARG1, MT-CO1, AGR2, IGHE
4MP:00053976.7ARG1, TNF, PDCD1LG2, SAFB, AGR2, IGHE
5MP:00053766.2SLC5A2, SAFB, PDCD1LG2, TNF, ARG1, MT-CO1

Publications for Cysticercosis

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50PubMed
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Articles related to Cysticercosis:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
High prevalence of cysticercosis in people with epilepsy in southern Rwanda. (24244783)
2013
2
A change in the epidemiology of bovine cysticercosis in Israel between 1973 and 2008 due to import of live cattle. (22620676)
2013
3
Asymptomatic disseminated cysticercosis. (24086907)
2013
4
Intramedullary cysticercosis of the spinal cord: a review of patients evaluated with MRI. (23747004)
2013
5
Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review. (23445359)
2013
6
Current status and perspectives of cysticercosis and taeniasis in Japan. (23467264)
2013
7
Diagnostic epitope variability within Taenia solium 8 kDa antigen family: implications for cysticercosis immunodetection. (22075212)
2012
8
Subcutaneous cysticercosis. (22885271)
2012
9
Multiple cystic brain metastases from adenocarcinoma mimicking cysticercosis. Case report. (21528368)
2012
10
Subcutaneous cysticercosis identified in chest radiography. (23168712)
2012
11
Risk factors of porcine cysticercosis in the Eastern Cape Province, South Africa. (22655065)
2012
12
An uncommon manifestation of a common tropical disease: disseminated cysticercosis. (24028915)
2012
13
Subcutaneous cervical cysticercosis in a child. (22754251)
2012
14
Isolated cysticercosis of the breast masquerading as a breast tumour: report of a case and review of literature. (22117855)
2011
15
Cysticercosis of the upper lip. (22529585)
2011
16
Soft tissue cysticercosis - Ultrasonographic spectrum of the disease. (21431036)
2011
17
Evaluation of the protective potential of a Taenia solium cysticercus mimotope on murine cysticercosis. (22027483)
2011
18
Orbital cysticercosis presenting as recurrent periorbital cellulitis in a four-year-old child. (20431389)
2010
19
Eradication of Taenia solium cysticercosis: a role for vaccination of pigs. (20470777)
2010
20
Comparison of ELISA and PCR assays for the diagnosis of porcine cysticercosis. (20542639)
2010
21
Disseminated cysticercosis in a child: whole-body MR diagnosis with the use of parallel imaging. (19949945)
2010
22
Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearance in vivo. (20045000)
2010
23
Mylohyoid cysticercosis: a rare submandibular mass. (19924665)
2009
24
Cysticercosis of soft tissue. (19260577)
2009
25
Isolated cardiac cysticercosis in an adolescent. (18316979)
2008
26
Serological responses in porcine cysticercosis: a link with the parasitological outcome of infection. (18328486)
2008
27
Extracranial cysticercosis of the parotid gland: a case report with a review of the literature. (17640431)
2008
28
Human cysticercosis and Indian scenario: a review. (19208982)
2008
29
Cysticercosis in a female Nicaraguan traveler. (17883469)
2007
30
Cysticercosis of temporalis muscle: an unusual cause of temporal headaches. A case report. (17955174)
2007
31
Pulmonary and cardiac cysticercosis: helical CT findings. (17548502)
2007
32
Taenia solium dUTPase: A potential target for anti-human cysticercosis. (17368551)
2007
33
Evaluation of a serological method for the detection of Taenia saginata cysticercosis using serum and meat juice samples. (17216238)
2007
34
Acute cysticercosis favours rapid and more severe lesions caused by Leishmania major and Leishmania mexicana infection, a role for alternatively activated macrophages. (17118349)
2006
35
Lack of specificity of a single positive 50-kDa band in the electroimmunotransfer blot (EITB) assay for cysticercosis. (16643523)
2006
36
Ocular manifestations of helminthic infections: onchocersiasis, cysticercosis, toxocariasis, and diffuse unilateral subacute neuroretinitis. (16770150)
2006
37
Optimizing therapy of seizures in patients with HIV and cysticercosis. (17190916)
2006
38
Challenges for control of taeniasis/cysticercosis in Indonesia. (16380290)
2006
39
Current status of Taenia solium and cysticercosis in Papua New Guinea. (16338165)
2006
40
Short report: cysticercosis in an Egyptian mummy of the late Ptolemaic period. (16606991)
2006
41
Cysticercosis/taeniasis in Asia and the Pacific. (15228810)
2004
42
Acquired brown syndrome secondary to superior oblique muscle cysticercosis. (12690365)
2003
43
PCR tools for the differential diagnosis of Taenia saginata and Taenia solium taeniasis/cysticercosis from different geographical locations. (12007441)
2002
44
Risk factors associated with taeniasis-cysticercosis in Lagamar, Minas Gerais State, Brazil. (9477700)
1998
45
Acute obstructive hydrocephalus due to cysticercosis during pregnancy. (18475345)
1994
46
Landau-Kleffner syndrome in cerebral cysticercosis. (7533144)
1994
47
Potential eradicability of taeniasis and cysticercosis. (8312963)
1993
48
The situation of cysticercosis/taeniasis in animals/man in Bali. (1822895)
1991
49
Immunity in taeniasis-cysticercosis I. Vaccination against Taenia taeniaeformis in rats using purified antigen. (874421)
1977
50
Studies on the zoonotic cycle of Taenia saginata taeniasis and cysticercosis in the Philippines. (1025038)
1976

Genetic Variations for Cysticercosis

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Expression for genes affiliated with Cysticercosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cysticercosis

Search GEO for disease gene expression data for Cysticercosis.

Pathways for genes affiliated with Cysticercosis

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29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Cysticercosis

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Cysticercosis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7ARG1
2gm-csf44 2811.3TNF, IL10
3monomethyl fumarate4410.3IL4, IL10
4tuberculin4410.1MIF, IL10, IL18
5hydrocortisone44 2 59 1113.1IGHE
6interferon gamma4410.1TNF, IL10, IL4
7mip 1alpha4410.0IL4, IL10, TNF
8natalizumab44 1111.0TNF, IL10, IL18
9indoleamine4410.0IL18, IL10, TNF
10imiquimod44 28 59 1113.0TNF, IL10, IL18
11prednisolone44 28 1112.0IGHE
12con a4410.0IL4, IL18, IL10
13groalpha4410.0TNF, IL10, IL18
14polymyxin b4410.0TNF, IL10, IL4
15okt3449.9TNF, IL10, IL4
16lipoteichoic acid449.9IL18, IL10, TNF
17dexamethasone44 49 28 1112.9IGHE
18cdp571449.9IL10, TNF
19cyclophosphamide44 49 1111.8MIF, IGHE
20etanercept44 49 1111.8TNF, IL10, IL18
21il-12449.8IL4, IL18, IL10, TNF
22polyinosinic-polycytidylic acid449.8IL4, IL18, IL10, TNF
23poly(i-c)449.8IL4, IL18, TNF
24il 10449.8TNF, IL10, IL18, IL4
25thalidomide44 49 59 1112.8IL18, IL10, MIF, TNF
26pentoxifylline44 1110.8TNF, IL10, IL18, IL4
27neopterin449.8TNF, IL10, IL18, IL4
28chloroquine44 2 49 28 1113.8IL4, IL18, IL10, TNF
29simvastatin44 49 59 28 11 2414.6TNF, IL10, IL18, IL4
30betaseron449.6IL4, IL10
31ionomycin449.6IL4, IL18, IL10, TNF
32rantes449.5TNF, MIF, IL10, IL18, IL4
33praziquantel44 1110.5IL4, IL10, IGHE
34sb 20358044 5910.5TNF, MIF, IL10, IL18, IL4
35tacrolimus44 49 1111.5TNF, IL10, IL18, IL4
36montelukast44 49 28 1112.5IGHE, IL10, IL4
37salbutamol44 49 28 11 2413.4IL18, IL10, IGHE
38budesonide44 49 1111.4TNF, IGHE, IL4
39fluticasone propionate44 49 59 1112.3IL4, IGHE, TNF
40omalizumab44 1110.3IL4, IGHE
41ivig449.2IL4, IL10, IGHE, TNF
42hydrogen44 2410.2ARG1, MT-CO1, DUT, MIF, IL18
43thymidine44 2410.1TNF, DUT, MIF, IL10, IL18, IL4
44infliximab44 49 1111.0TNF, IGHE, IL10, IL18, IL4
45tarc449.0TNF, IGHE, IL10, IL18, IL4
46histamine44 28 2410.9TNF, IGHE, IL10, IL18, IL4
47cyclosporin a44 28 5910.7TNF, IGHE, IL10, IL18, IL4
48vegf448.5TNF, ARG1, IGHE, MIF, IL10, IL18
49arginine448.4SAFB, ARG1, IGHE, IL18, IL4, SLC5A2
50allergens448.4IL4, IL18, IL10, IGHE, SAFB, RPLP2

GO Terms for genes affiliated with Cysticercosis

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16Gene Ontology
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Cellular components related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7TACSTD2, IL4, IL18, IL10, MIF, ARG1

Biological processes related to Cysticercosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:04519110.2IL10, IL4
2positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.2MIF, TNF
3receptor biosynthetic processGO:03280010.1TNF, IL10
4positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, IL10
5negative regulation of cytokine secretion involved in immune responseGO:00274010.1TNF, IL10
6positive regulation of chemokine biosynthetic processGO:04508010.1IL4, TNF
7negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
8type 2 immune responseGO:04209210.0IL4, IL18, IL10
9positive regulation of cytokine secretionGO:0507159.9IL10, MIF, TNF
10positive regulation of chemokine productionGO:0327229.9IL18, TNF
11negative regulation of growth of symbiont in hostGO:0441309.8IL10, TNF
12positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL10, IL4
13protein homotrimerizationGO:0702079.7MIF, ARG1
14response to drugGO:0424939.5IL4, IL10, ARG1, TNF
15inflammatory responseGO:0069549.4TNF, MIF, IL10, IL18

Molecular functions related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL18, IL10, MIF, TNF

Products for genes affiliated with Cysticercosis

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Sources for Cysticercosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet