MCID: CYS005
MIFTS: 54

Cysticercosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases, Neuronal diseases categories

Summaries for Cysticercosis

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NIH Rare Diseases:41 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards based summary: Cysticercosis, also known as neurocysticercosis, is related to tuberculosis and systemic lupus erythematosus. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Th1 Differentiation. The drugs praziquantel and albendazole and the compounds dextran sulfate sodium and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:9 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:3 Cysticercosis is a parasitic tissue infection caused by larval cysts of the tapeworm Taenia solium. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. A person gets cysticercosis by swallowing eggs found in the feces of a person who has an intestinal tapeworm.  People living in the same household with someone who has a tapeworm have a much higher risk of getting cysticercosis than people who don’t.

Wikipedia:63 Cysticercosis is a tissue infection caused by a young form (cysticercus) of the pork tapeworm (Taenia... more...

Aliases & Classifications for Cysticercosis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Cysticercosis, Aliases & Descriptions:

Name: Cysticercosis 9 41 11 43 47 3 60
Neurocysticercosis 9 41 43 3 60
Submacular Cysticercosis 41 60
Tapeworm Infection: Intestinal Taenia Solium 9
Intestinal Taenia Solium Infection 9
Tenia Solium Infectious Disease 9
 
Pork Tapeworm Infection 9
Tenia Solium Infection 60
Taeniasis 41
Teniasis 60
Pork 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
cysticercosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:10079
MeSH33 D003551
ICD9CM27 123.1
NCIt38 C34520
Orphanet47 1560
MESH via Orphanet34 D003551
ICD10 via Orphanet26 B69.0, B69.1, B69.8 B69.9, more
UMLS via Orphanet61 C0010678
ICD1025 B69, B69.9

Related Diseases for Cysticercosis

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Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Symptoms for Cysticercosis

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Drugs & Therapeutics for Cysticercosis

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Drug clinical trials:

Search ClinicalTrials for Cysticercosis

Search NIH Clinical Center for Cysticercosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Cysticercosis

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Anatomical Context for Cysticercosis

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MalaCards organs/tissues related to Cysticercosis:

31
Brain, Testes, Eye, Heart, Skin, Tongue, Spinal cord, Breast, Kidney, Salivary gland, Bone, Spleen, Liver, Pancreas, Thyroid, Temporal lobe

Animal Models for Cysticercosis or affiliated genes

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MGI Mouse Phenotypes related to Cysticercosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9TACSTD2, PDCD1LG2, MIF, TNF
2MP:00053848.1TNF, SAFB, MT-CO1, MIF, IL18, TACSTD2
3MP:00053977.8IGHE, TNF, SAFB, MIF, IL18, PDCD1LG2
4MP:00053877.7IGHE, TNF, MT-CO1, MIF, IL18, PDCD1LG2
5MP:00053767.1SLC5A2, IGHE, TNF, SAFB, MT-CO1, MIF

Publications for Cysticercosis

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Articles related to Cysticercosis:

(show top 50)    (show all 616)
idTitleAuthorsYear
1
Inferior rectus muscle ocular cysticercosis: A case report. (25892941)
2015
2
Toxic granulomatous anterior uveitis in live intracameral cysticercosis masquerading as leukocoria. (25433748)
2014
3
Immunology of Taenia solium taeniasis and human cysticercosis. (24962350)
2014
4
Of pigs and people--WHO prepares to battle cysticercosis. (25136715)
2014
5
Generalized Taenia crassiceps cysticercosis in a chinchilla (Chinchilla lanigera). (24126089)
2014
6
Prevalence of porcine cysticercosis in the Lake Kyoga Basin, Uganda. (25286901)
2014
7
Current status of taeniasis and cysticercosis in Vietnam. (24850954)
2014
8
Taenia eggs in a stabilization pond system with poor hydraulics: concern for human cysticercosis? (24355860)
2013
9
Occurrence and factors associated with bovine cysticercosis recorded in cattle at meat inspection in Denmark in 2004-2011. (23245844)
2013
10
Molecular identification of species of Taenia causing bovine cysticercosis in Ethiopia. (23452760)
2013
11
Disseminated cysticercosis. (24197175)
2013
12
Ocular cysticercosis in a 32-year-old man in Abuja: ultrasonic features as an aid in diagnosis. (24348016)
2013
13
Cyscicerci in the longus colli in disseminated cysticercosis: an unusual location for a common endemic disease. (23893275)
2013
14
Isolated brainstem cysticercosis. (23453152)
2013
15
High prevalence of cysticercosis in people with epilepsy in southern Rwanda. (24244783)
2013
16
The effect of oxfendazole treatment on muscle pathology in pigs infected with Taenia solium cysticercosis. (22883970)
2012
17
Multifocal cysticercosis with optical coherence tomography findings in a child. (22623867)
2012
18
Taeniasis and cysticercosis due to Taenia solium in Japan. (22248435)
2012
19
Diagnostic epitope variability within Taenia solium 8 kDa antigen family: implications for cysticercosis immunodetection. (22075212)
2012
20
Development and evaluation of flow through assay for detection of antibodies against porcine cysticercosis. (21602782)
2011
21
A dramatic case of intraventricular cysticercosis. (21670411)
2011
22
Cysticercosis of midbrain presenting with fluctuating ptosis. (22028538)
2011
23
Cysticercosis of the temporalis muscle causing temporal headache in a pregnant woman. (21529806)
2011
24
Disseminated cysticercosis. (21556243)
2011
25
Seroprevalence of Taenia saginata cysticercosis in the federal state of Lower Saxony in Germany. (21038810)
2010
26
Racemose cysticercosis in the cerebellar hemisphere. (20717513)
2010
27
Orbital cysticercosis presenting as recurrent periorbital cellulitis in a four-year-old child. (20431389)
2010
28
Intravitreal cysticercosis presenting as neovascular glaucoma. (20029152)
2010
29
Some risk factors for Taenia solium cysticercosis in semi-intensively raised pigs in Zuru, Nigeria. (20391368)
2010
30
Cytomorphological spectrum of subcutaneous and intramuscular cysticercosis: A study of 22 cases. (21157562)
2010
31
Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. (20035822)
2010
32
Development of a biomolecular assay for postmortem diagnosis of Taenia saginata Cysticercosis. (20618079)
2010
33
Cysticercosis: a rare cause of orbital infection. (19476757)
2009
34
Mylohyoid cysticercosis: a rare submandibular mass. (19924665)
2009
35
Seroepidemiologic survey of cysticercosis-taeniasis in four central highland districts of Papua, Indonesia. (19270286)
2009
36
Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis. (19041315)
2009
37
Subconjunctival cysticercosis. (19810391)
2009
38
Treatment of cerebral cysticercosis with albendazole in elevated dosages. (18392434)
2008
39
Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa. (18440704)
2008
40
Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. (18834668)
2008
41
Cysticercosis in a female Nicaraguan traveler. (17883469)
2007
42
The immune response in Taenia solium cysticercosis: protection and injury. (18042169)
2007
43
Oral cysticercosis: a collaborative study of 16 cases. (17395067)
2007
44
Primary spinal intradural extramedullary cysticercosis. (17719976)
2007
45
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
46
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
47
A case of intramuscular cysticercosis diagnosed definitively by mitochondrial DNA analysis of extremely calcified cysts. (16406683)
2006
48
Cysticercosis of the eye in South India--a case series. (16327117)
2005
49
Acquired brown syndrome secondary to superior oblique muscle cysticercosis. (12690365)
2003
50
Prevalence of antibodies to unique Taenia solium oncosphere antigens in taeniasis and human and porcine cysticercosis. (14640505)
2003

Variations for Cysticercosis

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Expression for genes affiliated with Cysticercosis

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Search GEO for disease gene expression data for Cysticercosis.

Pathways for genes affiliated with Cysticercosis

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Pathways related to Cysticercosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MIF, TNF
2
Show member pathways
IL27-mediated signaling events36
9.8IL18, TNF
39.8IL18, TNF
49.8IL18, TNF
59.8IL18, TNF
69.8IL18, TNF
79.8IL18, TNF
89.8TNF, IL18

Compounds for genes affiliated with Cysticercosis

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Compounds related to Cysticercosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dextran sulfate sodium4310.3IL18, MIF
2tuberculin4310.2IL18, MIF
3anakinra43 1211.2TNF, IL18
4natalizumab43 1211.2IL18, TNF
5il-124310.1IL18, TNF
6indoleamine4310.1IL18, TNF
7imiquimod43 59 28 1213.1IL18, TNF
8groalpha4310.1TNF, IL18
9gm-csf43 2811.1IL18, TNF
10lipoteichoic acid4310.0IL18, TNF
11levamisole43 1211.0IL18, IGHE
12polyinosinic-polycytidylic acid4310.0IL18, TNF
13etanercept43 49 1211.9IL18, TNF
14poly(i-c)439.9TNF, IL18
15thalidomide43 49 59 1212.9TNF, MIF, IL18
16salbutamol43 49 28 24 1213.9IGHE, IL18
17budesonide43 49 1211.9IGHE, TNF
18endotoxin439.8IL18, MIF, TNF
19curcumin439.8TNF, MIF, IL18
20fluticasone propionate43 49 59 1212.8IGHE, TNF
21il 10439.8TNF, IL18
22rantes439.8TNF, MIF, IL18
23mycophenolate mofetil43 49 1211.8TNF, IL18
24sb 20358043 5910.7IL18, MIF, TNF
25cyclophosphamide43 49 1211.7IGHE, MIF, IL18
26tarc439.7IGHE, TNF, IL18
27nicotine43 28 49 1212.7IGHE, MIF, IL18
28infliximab43 49 1211.7IGHE, TNF, IL18
29hydrocortisone43 2 59 1212.7MIF, TNF, IGHE
30prednisolone43 28 1211.7IL18, TNF, IGHE
31methotrexate49 43 1211.6IGHE, TNF, IL18
32n acetylcysteine439.6IL18, TNF, IGHE
33indomethacin43 28 59 1212.6IL18, TNF, IGHE
34norepinephrine43 24 1211.5IGHE, MIF, IL18
35hydrogen43 2410.4DUT, MT-CO1, MIF, IL18
36histamine43 28 2411.4IL18, TNF, IGHE
37estradiol43 24 1211.4IL18, MIF, SAFB
38lactate439.3IL18, MIF, TNF, IGHE
39thymidine43 2410.3IL18, MIF, DUT, TNF
40dexamethasone43 49 28 1212.3IL18, MIF, TNF, IGHE
41arginine439.3IGHE, SAFB, IL18, SLC5A2
42l-nmma439.3TNF, IGHE
43glucose439.3SAFB, MT-CO1, MIF, IL18, SLC5A2
44vegf439.3IL18, MIF, TNF, IGHE
45oxygen43 2410.3IL18, MIF, MT-CO1, TNF
46alanine439.0TACSTD2, IL18, MIF, SAFB, IGHE
47retinoic acid43 249.9IGHE, TNF, SAFB, MIF, IL18
48allergens438.8RPLP2, IL18, SAFB, IGHE
49serine438.8TNF, DUT, SAFB, MIF, IL18
50estrogen438.8IGHE, SAFB, MIF, IL18

GO Terms for genes affiliated with Cysticercosis

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Cellular components related to Cysticercosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.2MIF, RPLP2, TACSTD2, SLC5A2, DUT
2extracellular regionGO:00055768.0PDCD1LG2, IL18, MIF, TNF, IGHE

Biological processes related to Cysticercosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:0200034310.0MIF, TNF
2positive regulation of cytokine secretionGO:005071510.0TNF, MIF
3positive regulation of NF-kappaB import into nucleusGO:004234610.0IL18, TNF
4lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL18, TNF
5cellular response to organic cyclic compoundGO:00714079.9IL18, TNF
6positive regulation of interferon-gamma productionGO:00327299.8TNF, IL18
7positive regulation of MAP kinase activityGO:00434069.7TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:00331389.5MIF, TNF
9inflammatory responseGO:00069549.4IL18, MIF, TNF
10immune responseGO:00069559.0PDCD1LG2, IL18, IGHE

Molecular functions related to Cysticercosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4IL18, MIF, TNF

Products for genes affiliated with Cysticercosis

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Sources for Cysticercosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet