PORK
MCID: CYS005
MIFTS: 64

Cysticercosis (PORK) malady

Infectious diseases, Gastrointestinal diseases, Neuronal diseases categories

Summaries for Cysticercosis

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8Disease Ontology, 42NIH Rare Diseases, 3CDC, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards: Cysticercosis, also known as neurocysticercosis, is related to echinococcosis and hyperglycemia. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Leishmaniasis and Malaria. The drugs albendazole and praziquantel and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are no phenotypic analysis and cellular.

Disease Ontology:8 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:3 Cysticercosis is a parasitic tissue infection caused by larval cysts of the pork tapeworm. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. An individual acquires cysticercosis from ingesting eggs excreted by a person who has an intestinal tapeworm. People living in the same household with a tapeworm carrier have a much higher risk of getting cysticercosis than others.

Wikipedia:63 Cysticercosis is a tissue infection by the pork tapeworm (Taenia solium). People may have little or no... more...

Aliases & Classifications for Cysticercosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
cysticercosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

cysticercosis 8 42 10 44 48 60
neurocysticercosis 8 42 44 60
submacular cysticercosis 42 60
tapeworm infection: intestinal taenia solium 8
intestinal taenia solium infection 8
tenia solium infectious disease 8
pork tapeworm infection 8
taeniasis 42
pork 8


External Ids:

Disease Ontology8 DOID:10079
ICD9CM27 123.1
NCIt39 C34520
MeSH34 D003551
MESH via Orphanet35 D003551
SNOMED-CT via Orphanet57 105684008, 59051007
ICD10 via Orphanet26 B69.0, B69.1, B69.8 B69.9, more
UMLS via Orphanet61 C0010678
ICD1025 B69, B69.9

Related Diseases for Cysticercosis

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17GeneCards, 18GeneDecks
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Diseases related to Cysticercosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1echinococcosis30.8MT-CO1, STYX
2hyperglycemia30.7SLC5A2
3type 1 diabetes30.6STYX, IL10, IL4
4hepatitis30.0IL18
5adenocarcinoma30.0TACSTD2
6gastritis29.9MIF
7diabetes mellitus29.8TNF
8eclampsia29.8SPIN4
9hepatitis b29.8MIF
10schistosomiasis29.8IL4, IL10, IGHE
11tuberculosis29.7TNF, MIF, IL10, IL18, IL4
12taeniasis10.9
13type 1 diabetes mellitus10.6
14type 2 diabetes mellitus10.6
15maturity-onset diabetes of the young, type 110.6
16diabetic ketoacidosis10.5
17maturity-onset diabetes of the young10.5
18immunodysregulation, polyendocrinopathy and enteropathy x-linked10.5
19brittle diabetes10.5
20maturity-onset diabetes of the young, type 210.5
21maturity-onset diabetes of the young, type 610.5
22epiphyseal dysplasia multiple with early-onset diabetes mellitus10.5
23diabetes, type 210.5
24rh-mod syndrome10.5
25cerebritis10.4
26hepatitis e10.4
27toxocariasis10.3
28cervicitis10.2
29hydrocephalus10.2
30cranial nerve palsy10.1
31hypoglycemia10.1
32pseudotumor cerebri10.0
33lateral sinus thrombosis10.0
34eosinophilic meningitis10.0
35adenoma10.0
36pituitary adenoma10.0
37cystic echinococcosis10.0
38ascariasis10.0
39neuroretinitis10.0
40empty sella syndrome10.0
41onchocerciasis10.0
42fascioliasis10.0
43obstructive hydrocephalus10.0
44glaucoma10.0
45herpes simplex10.0DUT
46pancreatic cancer10.0TACSTD2
47glomerulonephritis10.0MIF
48hepatocellular carcinoma10.0ARG1
49acute myocardial infarction10.0MIF
50deficiency anemia10.0MIF

Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Clinical Features for Cysticercosis

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Drugs & Therapeutics for Cysticercosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cysticercosis

Drug clinical trials:

Search ClinicalTrials for Cysticercosis

Search NIH Clinical Center for Cysticercosis

Search CenterWatch for Cysticercosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cysticercosis

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Anatomical Context for Cysticercosis

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32MalaCards
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MalaCards organs/tissues related to Cysticercosis:

32
Brain, Testes, Eye, Heart, Skin, Tongue, Breast, Spinal cord, Kidney, Salivary gland, Liver, Thyroid, Spleen, Temporal lobe, Pancreas

Animal Models for Cysticercosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cysticercosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9SLC5A2, IGHE, PDCD1LG2
2MP:00053847.1MT-CO1, TNF, PDCD1LG2, SAFB, AGR2, MIF
3MP:00053876.7PDCD1LG2, TNF, ARG1, MT-CO1, AGR2, IGHE
4MP:00053976.7ARG1, TNF, PDCD1LG2, SAFB, AGR2, IGHE
5MP:00053766.2SLC5A2, SAFB, PDCD1LG2, TNF, ARG1, MT-CO1

Publications for Cysticercosis

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50PubMed
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Articles related to Cysticercosis:

(show top 50)    (show all 577)
idTitleAuthorsYear
1
Generalized Taenia crassiceps cysticercosis in a chinchilla (Chinchilla lanigera). (24126089)
2014
2
Taenia eggs in a stabilization pond system with poor hydraulics: concern for human cysticercosis? (24355860)
2013
3
Expression and immunolocalisation of TpFABP as a candidate antigen for the serodiagnosis of rabbit Taenia pisiformis cysticercosis. (24325873)
2013
4
Taeniasis and cysticercosis due to Taenia solium in Japan. (22248435)
2012
5
Immunological and molecular diagnosis of cysticercosis. (23265553)
2012
6
Verifying elimination programs with a special emphasis on cysticercosis endpoints and postelimination surveillance. (23213490)
2012
7
Emerging of cysticercosis in Europe: a concern. (22669611)
2012
8
Solitary intramuscular cysticercosis-A report of two cases. (23393502)
2011
9
Cysticercosis of lumbar spine, mimicking spinal subarachnoid tumor. (21474075)
2011
10
Cysticercosis of the central nervous system: how should it be managed? (21788891)
2011
11
Asymptomatic cysticercosis in wistar albino rats: A note of caution to all biomedical researchers. (21572670)
2011
12
Limits of the therapeutic properties of synthetic S3Pvac anti-cysticercosis vaccine. (21177039)
2011
13
Dilemmas in cytodiagnosis of subcutaneous swellings: mimics and look-alikes of cysticercosis. (20876327)
2010
14
Animal cysticercosis in indigenous Brazilian villages. (20624354)
2010
15
Age-related infection and transmission patterns of human cysticercosis. (19683531)
2010
16
Parasiticidal effect of 16alpha-bromoepiandrosterone (EpiBr) in amoebiasis and cysticercosis. (20403456)
2010
17
Cysticercosis: a rare cause of orbital infection. (19476757)
2009
18
Neuro cysticercosis with subcutaneous nodules. (19736446)
2009
19
Disseminated cysticercosis. (19211428)
2009
20
Development of an immunobinding dot-blot assay as an alternative for the serodiagnosis of human cysticercosis. (19317923)
2009
21
Taenia asiatica and pig cysticercosis. (18752896)
2008
22
Case-control study to identify risk factors for bovine cysticercosis on farms in Switzerland. (18371237)
2008
23
Tear IgA-ELISA: a novel and sensitive method for diagnosis of ophthalmic cysticercosis. (18462701)
2008
24
Disseminated cysticercosis in an infant. (19129574)
2008
25
Focal spinal intramedullary cysticercosis. (18551821)
2008
26
Prevalence of Taenia solium porcine cysticercosis in the Eastern, Southern and Western provinces of Zambia. (17468023)
2008
27
Inaugural meeting of the Cysticercosis Working Group in Europe. (19046503)
2008
28
Oral cysticercosis: a collaborative study of 16 cases. (17395067)
2007
29
Simultaneous brain and ocular cysticercosis in a five-year-old boy. (17596821)
2007
30
Oral cysticercosis. (16388881)
2007
31
Nitric oxide contributes to host resistance against experimental Taenia crassiceps cysticercosis. (17206501)
2007
32
Extraocular muscle cysticercosis mimicking idiopathic orbital inflammation: case report. (17768567)
2007
33
Validation of meat inspection results for Taenia saginata cysticercosis by PCR-restriction fragment length polymorphism. (17265888)
2007
34
Unifocal, subconjunctival twin cysticercosis cysts. (17274340)
2007
35
Contribution of immunodiagnostic tests to epidemiological/intervention studies of cysticercosis/taeniosis in Mexico. (18042170)
2007
36
Spinal cord cysticercosis: a case report. (17153691)
2006
37
Taeniasis/cysticercosis in Papua (Irian Jaya), Indonesia. (16376603)
2006
38
High prevalence of Taenia saginata taeniasis and status of Taenia solium cysticercosis in Bali, Indonesia, 2002-2004. (16199069)
2006
39
Veterinary public health activities at FAO: cysticercosis and echinococcosis. (16343986)
2006
40
Extraneural cysticercosis - presenting as painless cervical swellings. (16239283)
2006
41
Taeniasis/cysticercosis in a Tibetan population in Sichuan Province, China. (17166477)
2006
42
Taenia solium taeniasis and cysticercosis in three communities in north Vietnam. (16398757)
2006
43
Cysticercosis of the breast: an uncommon cause of lumps. (16509848)
2006
44
Sero-prevalence of Taenia solium cysticercosis and Taenia solium taeniasis in California, USA. (15644066)
2005
45
Cysticercosis cellulose cutis. (17664741)
2001
46
Human cerebral cysticercosis: immunolocalization of a sodium-dependent glucose cotransporter (SGLT) in larval and adult tapeworms. (11426712)
2001
47
Transient hemifacial spasm associated with subarachnoid brainstem cysticercosis: a case report. (9795954)
1998
48
Taeniasis-cysticercosis in Honduras. (1755064)
1991
49
Taenia solium taeniasis and cysticercosis in a Mexican village. (3194663)
1988
50
Research needs in taeniasis-cysticercosis. (1085668)
1976

Genetic Variations for Cysticercosis

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Expression for genes affiliated with Cysticercosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cysticercosis

Search GEO for disease gene expression data for Cysticercosis.

Pathways for genes affiliated with Cysticercosis

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29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Cysticercosis

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Cysticercosis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.7ARG1
2gm-csf44 2811.3TNF, IL10
3monomethyl fumarate4410.3IL10, IL4
4tuberculin4410.1MIF, IL10, IL18
5hydrocortisone44 2 59 1113.1IGHE
6interferon gamma4410.1TNF, IL10, IL4
7mip 1alpha4410.0IL10, IL4, TNF
8natalizumab44 1111.0IL18, IL10, TNF
9indoleamine4410.0IL18, TNF, IL10
10imiquimod44 28 59 1113.0TNF, IL10, IL18
11prednisolone44 28 1112.0IGHE
12con a4410.0IL18, IL10, IL4
13groalpha4410.0TNF, IL18, IL10
14polymyxin b4410.0IL4, TNF, IL10
15okt3449.9IL10, TNF, IL4
16lipoteichoic acid449.9IL18, TNF, IL10
17betaseron449.9IL4, IL10
18dexamethasone44 49 28 1112.9IGHE
19cyclophosphamide44 49 1111.8IGHE, MIF
20etanercept44 49 1111.8IL18, TNF, IL10
21il-12449.8IL10, TNF, IL18, IL4
22polyinosinic-polycytidylic acid449.8IL4, IL18, IL10, TNF
23poly(i-c)449.8TNF, IL4, IL18
24il 10449.8TNF, IL18, IL10, IL4
25thalidomide44 49 59 1112.8IL18, TNF, MIF, IL10
26pentoxifylline44 1110.8IL4, IL18, IL10, TNF
27neopterin449.8IL4, IL10, TNF, IL18
28chloroquine44 2 49 28 1113.8IL10, IL18, TNF, IL4
29simvastatin44 49 59 28 11 2414.6IL4, IL18, IL10, TNF
30cdp571449.6TNF, IL10
31ionomycin449.6IL10, IL4, IL18, TNF
32rantes449.5MIF, IL10, IL18, IL4, TNF
33praziquantel44 1110.5IL10, IL4, IGHE
34sb 20358044 5910.5IL10, IL18, TNF, MIF, IL4
35tacrolimus44 49 1111.5IL18, IL10, TNF, IL4
36montelukast44 49 28 1112.5IL4, IL10, IGHE
37salbutamol44 49 28 11 2413.4IL18, IL10, IGHE
38budesonide44 49 1111.4IL4, TNF, IGHE
39fluticasone propionate44 49 59 1112.3IL4, IGHE, TNF
40omalizumab44 1110.3IL4, IGHE
41ivig449.2IGHE, IL10, IL4, TNF
42hydrogen44 2410.2MIF, IL18, MT-CO1, ARG1, DUT
43thymidine44 2410.1IL18, IL4, MIF, DUT, TNF, IL10
44infliximab44 49 1111.0IGHE, IL10, IL18, IL4, TNF
45tarc449.0TNF, IGHE, IL18, IL4, IL10
46histamine44 28 2410.9IL18, TNF, IGHE, IL10, IL4
47cyclosporin a44 28 5910.7IL4, IL10, IGHE, TNF, IL18
48vegf448.5IL10, IL4, IL18, MIF, IGHE, ARG1
49arginine448.4SLC5A2, ARG1, IGHE, IL18, IL4, SAFB
50allergens448.4IL18, IL4, IL10, RPLP2, SAFB, IGHE

GO Terms for genes affiliated with Cysticercosis

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16Gene Ontology
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Cellular components related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7TACSTD2, IL4, IL18, IL10, MIF, ARG1

Biological processes related to Cysticercosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:04519110.2IL10, IL4
2positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.2MIF, TNF
3receptor biosynthetic processGO:03280010.1TNF, IL10
4positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, IL10
5negative regulation of cytokine secretion involved in immune responseGO:00274010.1TNF, IL10
6positive regulation of chemokine biosynthetic processGO:04508010.1IL4, TNF
7negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
8type 2 immune responseGO:04209210.0IL4, IL18, IL10
9positive regulation of cytokine secretionGO:0507159.9IL10, MIF, TNF
10positive regulation of chemokine productionGO:0327229.9IL18, TNF
11negative regulation of growth of symbiont in hostGO:0441309.8IL10, TNF
12positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL10, IL4
13protein homotrimerizationGO:0702079.7MIF, ARG1
14response to drugGO:0424939.5IL4, IL10, ARG1, TNF
15inflammatory responseGO:0069549.4TNF, MIF, IL10, IL18

Molecular functions related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL18, IL10, MIF, TNF

Products for genes affiliated with Cysticercosis

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Sources for Cysticercosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet