PORK
MCID: CYS005
MIFTS: 58

Cysticercosis (PORK) malady

Infectious, Gastrointestinal, Neuronal categories

Summaries for Cysticercosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards: Cysticercosis, also known as neurocysticercosis, is related to type 1 diabetes and adenocarcinoma. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Leishmaniasis and Malaria. The drugs praziquantel and albendazole and the compounds endotoxin and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and spinal cord, and related mouse phenotypes are no phenotypic analysis and cellular.

Disease Ontology:8 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:3 Cysticercosis is a parasitic tissue infection caused by larval cysts of the pork tapeworm. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. An individual acquires cysticercosis from ingesting eggs excreted by a person who has an intestinal tapeworm. People living in the same household with a tapeworm carrier have a much higher risk of getting cysticercosis than others.

Wikipedia:64 Cysticercosis refers to tissue infection after exposure to eggs of Taenia solium, the pork tapeworm. The... more...

Aliases & Classifications for Cysticercosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Gastrointestinal, Neuronal


Characteristics (Orphanet epidemiological data):

49
cysticercosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

cysticercosis 8 43 10 45 49 61
neurocysticercosis 8 43 45 61
submacular cysticercosis 43 61
tapeworm infection: intestinal taenia solium 8
intestinal taenia solium infection 8
tenia solium infectious disease 8
pork tapeworm infection 8
taeniasis 43
pork 8


External Ids:

Disease Ontology8 DOID:10079
ICD9CM27 123.1
NCIt40 C34520
MeSH35 D003551
MESH via Orphanet36 D003551
ICD10 via Orphanet26 B69
SNOMED-CT via Orphanet58 105684008, 59051007
UMLS via Orphanet62 C0010678
ICD1025 B69, B69.9

Related Diseases for Cysticercosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cysticercosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes30.7STYX, IL10, IL4
2adenocarcinoma30.0TACSTD2
3hepatitis b29.9MIF
4eclampsia29.8SPIN4
5hepatitis c29.8IL18, IL10, ARG1
6tuberculosis29.8TNF, MIF, IL10, IL18, IL4
7taeniasis10.9
8type 1 diabetes mellitus10.6
9type 2 diabetes mellitus10.6
10maturity-onset diabetes of the young, type 110.6
11cystic echinococcosis10.5
12diabetic ketoacidosis10.5
13orbital cyst10.5
14maturity-onset diabetes of the young10.5
15immunodysregulation, polyendocrinopathy and enteropathy x-linked10.5
16brittle diabetes10.5
17maturity-onset diabetes of the young, type 210.5
18maturity-onset diabetes of the young, type 610.5
19epiphyseal dysplasia multiple with early-onset diabetes mellitus10.5
20diabetes, type 210.5
21rh-mod syndrome10.5
22toxocariasis10.3
23hepatitis a10.2
24n syndrome10.1
25headache10.1
26hypoglycemia10.1
27pseudotumor cerebri10.1
28lateral sinus thrombosis10.1
29eosinophilic meningitis10.1
30adenoma10.1
31myokymia10.1
32ascariasis10.0
33neuroretinitis10.0
34empty sella syndrome10.0
35onchocerciasis10.0
36fascioliasis10.0
37obstructive hydrocephalus10.0
38brown syndrome10.0
39hyperglycemia10.0SLC5A2
40herpes simplex10.0DUT
41pancreatic cancer10.0TACSTD2
42glomerulonephritis10.0MIF
43hepatocellular carcinoma10.0ARG1
44acute myocardial infarction10.0MIF
45deficiency anemia10.0MIF
46gastritis10.0MIF
47endometriosis10.0MIF
48keratitis10.0MIF
49hepatitis10.0IL18
50lupus erythematosus10.0IL18

Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Clinical Features for Cysticercosis

Drugs & Therapeutics for Cysticercosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cysticercosis

Drug clinical trials:

Search ClinicalTrials for Cysticercosis

Search NIH Clinical Center for Cysticercosis

Search CenterWatch for Cysticercosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cysticercosis

Anatomical Context for Cysticercosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Cysticercosis:

33
Spleen, Brain, Spinal cord, Heart, Small intestine, Kidney, Liver, Pancreas, Thyroid, Salivary gland, Breast, T cells, B cells, Temporal lobe, Tongue

Animal Models for Cysticercosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cysticercosis

Sources:
51PubMed
See all sources

Articles related to Cysticercosis:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Occurrence and factors associated with bovine cysticercosis recorded in cattle at meat inspection in Denmark in 2004-2011. (23245844)
2013
2
Molecular identification of species of Taenia causing bovine cysticercosis in Ethiopia. (23452760)
2013
3
Control of cysticercosis in Madagascar: beware of the pitfalls. (24145061)
2013
4
Parasite antigen in serum predicts the presence of viable brain parasites in patients with apparently calcified cysticercosis only. (23788241)
2013
5
Cerebellar cysticercosis caused by larval Taenia crassiceps tapeworm in immunocompetent woman, Germany. (24274258)
2013
6
Taenia solium taeniosis/cysticercosis in Africa: risk factors, epidemiology and prospects for control using vaccination. (23312868)
2013
7
Sex-associated expression of co-stimulatory molecules CD80, CD86, and accessory molecules, PDL-1, PDL-2 and MHC-II, in F480+ macrophages during murine cysticercosis. (23533995)
2013
8
Taenia solium cysticercosis: the case of Cuba. (23951367)
2013
9
Spinal cysticercosis. (22575026)
2013
10
Multifocal cysticercosis with optical coherence tomography findings in a child. (22623867)
2012
11
Validation of an immunohistochemical assay for bovine cysticercosis, with comparison to a standard histological method. (22169223)
2012
12
Changes in knowledge and practices related to taeniasis/cysticercosis after health education in a south Indian community. (24029395)
2012
13
A review of cases of human cysticercosis in Canada. (22547511)
2012
14
Disseminated cutaneous cysticercosis and neurocysticercosis: A rare occurrence. (23130290)
2012
15
Association between epilepsy and cysticercosis and toxocariasis: a population-based case-control study in a slum in India. (23106145)
2012
16
A review on diagnostic and preventive aspects of cystic echinococcosis and human cysticercosis. (23767016)
2012
17
Efficacy of diverse antiparasitic treatments for cysticercosis in the pig model. (22855760)
2012
18
Positional vomiting as the initial manifestation of Bruns syndrome due to cysticercosis in the fourth ventricle: a symptom reminiscent of an old disease. (22286184)
2012
19
Influence of gender on cardiac and encephalic inflammation in the elderly with cysticercosis: a case control study. (23056059)
2012
20
Spinal intramedullary cysticercosis: a case report and literature review. (21814474)
2011
21
Public health implications of cysticercosis acquired in the United States. (21192847)
2011
22
Oral cysticercosis-a rare presentation. (21803314)
2011
23
Immunolocalization of TSOL18 and TSOL45-1A, the successful protective peptides against porcine cysticercosis, in Taenia solium oncospheres. (21211050)
2011
24
Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. (20035822)
2010
25
An ultrasonographic evaluation of solitary muscular and soft tissue cysticercosis. (21209548)
2010
26
Proptosis of eyeball in children with medial rectus cysticercosis: report of 2 cases. (19882505)
2010
27
Cardiac cysticercosis. (19380525)
2009
28
A survey of bovine cysticercosis/human taeniosis in Northern Turkana District, Kenya. (19329200)
2009
29
Seroprevalence to the antigens of Taenia solium cysticercosis among residents of three villages in Burkina Faso: a cross-sectional study. (19936298)
2009
30
Taenia crassiceps cysticercosis: variations in its parasite growth permissiveness that encounter with local immune features in BALB/c substrains. (19735657)
2009
31
Unusual presentation of orbital cysticercosis-ptosis, diminution of vision and medial rectus weakness: a case report. (19918504)
2009
32
A serological study of cysticercosis in patients with HIV. (19738997)
2009
33
Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa. (18440704)
2008
34
Anterior chamber cysticercosis. (18952654)
2008
35
Vaccines against cysticercosis. (18393905)
2008
36
Use of ProteinChip technology for identifying biomarkers of parasitic diseases: the example of porcine cysticercosis (Taenia solium). (18823977)
2008
37
Heart involvement in disseminated cysticercosis- a case report and review of literature. (19240318)
2008
38
Optic nerve cysticercosis. (19068376)
2008
39
Spinal intramedullary cysticercosis of the conus medullaris. (18416368)
2008
40
Evaluation of immunodiagnostics for toxocarosis in experimental porcine cysticercosis. (17207154)
2007
41
Cysteine proteinase inhibitors in murine cysticercosis. (16870795)
2006
42
Extensive brain and muscular cysticercosis. (16476923)
2006
43
Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A. (16629704)
2006
44
Simultaneous intraocular and bilateral extraocular muscle involvement in a case of disseminated cysticercosis. (16779570)
2005
45
Atypical presentations of orbital cysticercosis. (16250224)
2005
46
Prevalence of antibodies to unique Taenia solium oncosphere antigens in taeniasis and human and porcine cysticercosis. (14640505)
2003
47
Taenia solium cysticercosis and human taeniasis in the Nsukka area of Enugu State, Nigeria. (7487226)
1995
48
Control of Taenia solium taeniasis and cysticercosis by focus-oriented chemotherapy of taeniasis. (1822907)
1991
49
Taeniasis-cysticercosis in Australia. (875783)
1977
50
Somatic taeniasis (solium cysticercosis). (20989936)
1946

Genetic Variations for Cysticercosis

Expression for genes affiliated with Cysticercosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cysticercosis

Search GEO for disease gene expression data for Cysticercosis.

Pathways for genes affiliated with Cysticercosis

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN
See all sources

Compounds for genes affiliated with Cysticercosis

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Cysticercosis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.7ARG1
2gm-csf45 2911.3TNF, IL10
3monomethyl fumarate4510.3IL4, IL10
4tuberculin4510.1MIF, IL10, IL18
5hydrocortisone45 2 60 1113.1IGHE
6interferon gamma4510.1TNF, IL10, IL4
7mip 1alpha4510.0IL4, IL10, TNF
8natalizumab45 1111.0TNF, IL10, IL18
9indoleamine4510.0IL18, IL10, TNF
10imiquimod45 29 60 1113.0TNF, IL10, IL18
11prednisolone45 29 1112.0IGHE
12con a4510.0IL4, IL18, IL10
13groalpha4510.0TNF, IL10, IL18
14polymyxin b4510.0TNF, IL10, IL4
15okt3459.9TNF, IL10, IL4
16lipoteichoic acid459.9IL18, IL10, TNF
17dexamethasone45 50 29 1112.9IGHE
18cdp571459.9IL10, TNF
19cyclophosphamide45 50 1111.8MIF, IGHE
20etanercept45 50 1111.8TNF, IL10, IL18
21il-12459.8IL4, IL18, IL10, TNF
22polyinosinic-polycytidylic acid459.8IL4, IL18, IL10, TNF
23poly(i-c)459.8IL4, IL18, TNF
24il 10459.8TNF, IL10, IL18, IL4
25thalidomide45 50 60 1112.8IL18, IL10, MIF, TNF
26pentoxifylline45 1110.8TNF, IL10, IL18, IL4
27neopterin459.8TNF, IL10, IL18, IL4
28chloroquine45 2 50 29 1113.8IL4, IL18, IL10, TNF
29simvastatin45 50 60 29 11 2414.6TNF, IL10, IL18, IL4
30betaseron459.6IL4, IL10
31ionomycin459.6IL4, IL18, IL10, TNF
32rantes459.5TNF, MIF, IL10, IL18, IL4
33praziquantel45 1110.5IL4, IL10, IGHE
34sb 20358045 6010.5TNF, MIF, IL10, IL18, IL4
35tacrolimus45 50 1111.5TNF, IL10, IL18, IL4
36montelukast45 50 29 1112.5IGHE, IL10, IL4
37salbutamol45 50 29 11 2413.4IL18, IL10, IGHE
38budesonide45 50 1111.4TNF, IGHE, IL4
39fluticasone propionate45 50 60 1112.3IL4, IGHE, TNF
40omalizumab45 1110.3IL4, IGHE
41ivig459.2IL4, IL10, IGHE, TNF
42hydrogen45 2410.2ARG1, MT-CO1, DUT, MIF, IL18
43thymidine45 2410.1TNF, DUT, MIF, IL10, IL18, IL4
44infliximab45 50 1111.0TNF, IGHE, IL10, IL18, IL4
45tarc459.0TNF, IGHE, IL10, IL18, IL4
46histamine45 29 2410.9TNF, IGHE, IL10, IL18, IL4
47cyclosporin a45 29 6010.7TNF, IGHE, IL10, IL18, IL4
48vegf458.5TNF, ARG1, IGHE, MIF, IL10, IL18
49arginine458.4SAFB, ARG1, IGHE, IL18, IL4, SLC5A2
50allergens458.4IL4, IL18, IL10, IGHE, SAFB, RPLP2

GO Terms for genes affiliated with Cysticercosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7TACSTD2, IL4, IL18, IL10, MIF, ARG1

Biological processes related to Cysticercosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of isotype switchingGO:04519110.2IL10, IL4
2positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.2MIF, TNF
3receptor biosynthetic processGO:03280010.1TNF, IL10
4positive regulation of MHC class II biosynthetic processGO:04534810.1IL4, IL10
5negative regulation of cytokine secretion involved in immune responseGO:00274010.1TNF, IL10
6positive regulation of chemokine biosynthetic processGO:04508010.1IL4, TNF
7negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
8type 2 immune responseGO:04209210.0IL4, IL18, IL10
9positive regulation of cytokine secretionGO:0507159.9IL10, MIF, TNF
10positive regulation of chemokine productionGO:0327229.9IL18, TNF
11negative regulation of growth of symbiont in hostGO:0441309.8IL10, TNF
12positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.8TNF, IL10, IL4
13protein homotrimerizationGO:0702079.7MIF, ARG1
14response to drugGO:0424939.5IL4, IL10, ARG1, TNF
15inflammatory responseGO:0069549.4TNF, MIF, IL10, IL18

Molecular functions related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL4, IL18, IL10, MIF, TNF

Products for genes affiliated with Cysticercosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cysticercosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet