PORK
MCID: CYS005
MIFTS: 63

Cysticercosis (PORK) malady

Rare diseases, Infectious diseases, Neuronal diseases, Gastrointestinal diseases categories

Summaries for Cysticercosis

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9Disease Ontology, 44NIH Rare Diseases, 4CDC, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards: Cysticercosis, also known as neurocysticercosis, is related to tuberculosis and taeniasis. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Th1 Differentiation. The drugs albendazole and praziquantel and the compounds dextran sulfate sodium and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:9 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:4 Cysticercosis is a parasitic tissue infection caused by larval cysts of the tapeworm Taenia solium. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. A person gets cysticercosis by swallowing eggs found in the feces of a person who has an intestinal tapeworm.  People living in the same household with someone who has a tapeworm have a much higher risk of getting cysticercosis than people who don’t.

Wikipedia:66 Cysticercosis is a tissue infection by the pork tapeworm (Taenia solium). People may have little or no... more...

Aliases & Classifications for Cysticercosis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 28ICD9CM, 41NCIt, 36MeSH, 59SNOMED-CT, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
cysticercosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

cysticercosis 9 44 11 46 50 63
neurocysticercosis 9 44 46 63
submacular cysticercosis 44 63
tapeworm infection: intestinal taenia solium 9
intestinal taenia solium infection 9
tenia solium infectious disease 9
pork tapeworm infection 9
taeniasis 44
pork 9


External Ids:

Disease Ontology9 DOID:10079
ICD9CM28 123.1
NCIt41 C34520
MeSH36 D003551
MESH via Orphanet37 D003551
SNOMED-CT via Orphanet60 105684008, 59051007
ICD10 via Orphanet27 B69.0, B69.1, B69.8 B69.9, more
UMLS via Orphanet64 C0010678
ICD1026 B69, B69.9

Related Diseases for Cysticercosis

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18GeneCards, 19GeneDecks
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Diseases related to Cysticercosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis29.8TNF, MIF, IL18
2taeniasis10.9
3echinococcosis10.6
4cerebritis10.5
5toxocariasis10.3
6hydrocephalus10.2
7cranial nerve palsy10.2
8cervicitis10.2
9headache10.2
10eosinophilic meningitis10.1
11pseudotumor cerebri10.1
12lateral sinus thrombosis10.1
13adenoma10.1
14pituitary adenoma10.1
15myokymia10.1
16ascariasis10.1
17cystic echinococcosis10.1
18onchocerciasis10.1
19fascioliasis10.1
20neuroretinitis10.1
21empty sella syndrome10.1
22obstructive hydrocephalus10.1
23adenocarcinoma10.1
24glaucoma10.1
25hepatitis10.1
26malaria10.0MIF, TNF
27cerebral malaria10.0MIF, TNF
28acute graft versus host disease10.0IL18, TNF
29adult respiratory distress syndrome10.0TNF, MIF
30pulmonary sarcoidosis10.0IL18, TNF
31plasmodium falciparum malaria10.0IL18, MIF
32behcet's disease10.0IL18, TNF
33extrinsic allergic alveolitis10.0IL18, IGHE
34allergic rhinitis10.0IGHE, IL18
35synovitis10.0IL18, TNF
36granulomatous gastritis10.0
37enterobiasis10.0
38hymenolepiasis10.0
39megaloblastic anemia10.0
40gastritis10.0
41graft versus host disease10.0TNF, IL18
42sarcoidosis10.0IL18, MIF, TNF
43ulcerative colitis10.0TNF, MIF, IL18
44sepsis10.0IL18, MIF, TNF
45inflammatory bowel disease10.0TNF, MIF, IL18
46rheumatic disease10.0IL18, TNF
47atopy9.9IGHE, MIF, IL18
48multiple sclerosis9.9TNF, MIF, IL18
49insulin resistance9.9TNF, MIF, IL18, SLC5A2
50skin disease9.9IL18, TNF, IGHE

Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Symptoms for Cysticercosis

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Drugs & Therapeutics for Cysticercosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Cysticercosis

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Search CenterWatch for Cysticercosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cysticercosis

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Anatomical Context for Cysticercosis

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34MalaCards
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MalaCards organs/tissues related to Cysticercosis:

34
Brain, Testes, Eye, Heart, Skin, Breast, Tongue, Spinal cord, Salivary gland, Kidney, Liver, Thyroid, Spleen, Temporal lobe, Pancreas

Animal Models for Cysticercosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cysticercosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9TACSTD2, PDCD1LG2, MIF, TNF
2MP:00053848.1TNF, SAFB, MT-CO1, MIF, IL18, TACSTD2
3MP:00053977.8IGHE, TNF, SAFB, MIF, IL18, PDCD1LG2
4MP:00053877.7IGHE, TNF, MT-CO1, MIF, IL18, PDCD1LG2
5MP:00053767.1SLC5A2, IGHE, TNF, SAFB, MT-CO1, MIF

Publications for Cysticercosis

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53PubMed
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Articles related to Cysticercosis:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Generalized Taenia crassiceps cysticercosis in a chinchilla (Chinchilla lanigera). (24126089)
2014
2
Taenia eggs in a stabilization pond system with poor hydraulics: concern for human cysticercosis? (24355860)
2013
3
Occurrence and factors associated with bovine cysticercosis recorded in cattle at meat inspection in Denmark in 2004-2011. (23245844)
2013
4
Molecular identification of species of Taenia causing bovine cysticercosis in Ethiopia. (23452760)
2013
5
Disseminated cysticercosis. (24197175)
2013
6
Ocular cysticercosis in a 32-year-old man in Abuja: ultrasonic features as an aid in diagnosis. (24348016)
2013
7
Cyscicerci in the longus colli in disseminated cysticercosis: an unusual location for a common endemic disease. (23893275)
2013
8
Isolated brainstem cysticercosis. (23453152)
2013
9
High prevalence of cysticercosis in people with epilepsy in southern Rwanda. (24244783)
2013
10
An epidemiological survey on the determination of Taenia saginata cysticercosis in Iran, using a PCR assay. (23571031)
2013
11
The effect of oxfendazole treatment on muscle pathology in pigs infected with Taenia solium cysticercosis. (22883970)
2012
12
Multifocal cysticercosis with optical coherence tomography findings in a child. (22623867)
2012
13
Taeniasis and cysticercosis due to Taenia solium in Japan. (22248435)
2012
14
Diagnostic epitope variability within Taenia solium 8 kDa antigen family: implications for cysticercosis immunodetection. (22075212)
2012
15
Development and evaluation of flow through assay for detection of antibodies against porcine cysticercosis. (21602782)
2011
16
A dramatic case of intraventricular cysticercosis. (21670411)
2011
17
Cysticercosis of midbrain presenting with fluctuating ptosis. (22028538)
2011
18
Cysticercosis of the temporalis muscle causing temporal headache in a pregnant woman. (21529806)
2011
19
Disseminated cysticercosis. (21556243)
2011
20
Spinal intramedullary cysticercosis: a case report and literature review. (21814474)
2011
21
Seroprevalence of Taenia saginata cysticercosis in the federal state of Lower Saxony in Germany. (21038810)
2010
22
Racemose cysticercosis in the cerebellar hemisphere. (20717513)
2010
23
Orbital cysticercosis presenting as recurrent periorbital cellulitis in a four-year-old child. (20431389)
2010
24
Intravitreal cysticercosis presenting as neovascular glaucoma. (20029152)
2010
25
Some risk factors for Taenia solium cysticercosis in semi-intensively raised pigs in Zuru, Nigeria. (20391368)
2010
26
Cytomorphological spectrum of subcutaneous and intramuscular cysticercosis: A study of 22 cases. (21157562)
2010
27
Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. (20035822)
2010
28
An ultrasonographic evaluation of solitary muscular and soft tissue cysticercosis. (21209548)
2010
29
Cysticercosis: a rare cause of orbital infection. (19476757)
2009
30
Mylohyoid cysticercosis: a rare submandibular mass. (19924665)
2009
31
Seroepidemiologic survey of cysticercosis-taeniasis in four central highland districts of Papua, Indonesia. (19270286)
2009
32
Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis. (19041315)
2009
33
Subconjunctival cysticercosis. (19810391)
2009
34
Subcutaneous and intramuscular cysticercosis: high-resolution sonography. (19736438)
2009
35
Treatment of cerebral cysticercosis with albendazole in elevated dosages. (18392434)
2008
36
Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa. (18440704)
2008
37
Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. (18834668)
2008
38
Cysticercosis in a female Nicaraguan traveler. (17883469)
2007
39
The immune response in Taenia solium cysticercosis: protection and injury. (18042169)
2007
40
Oral cysticercosis: a collaborative study of 16 cases. (17395067)
2007
41
Primary spinal intradural extramedullary cysticercosis. (17719976)
2007
42
A descriptive study of 36 cases of solitary soft tissue cysticercosis at Ramathibodi Hospital from surgical specimens during 1990-2006. (17877213)
2007
43
Simultaneous brain and ocular cysticercosis in a five-year-old boy. (17596821)
2007
44
Isolation of a 14 kDa antigen from Taenia solium cyst fluid by HPLC and its evaluation in enzyme linked immunosorbent assay for diagnosis of porcine cysticercosis. (17101161)
2007
45
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
46
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
47
A case of intramuscular cysticercosis diagnosed definitively by mitochondrial DNA analysis of extremely calcified cysts. (16406683)
2006
48
Spinal cord cysticercosis: a case report. (17153691)
2006
49
Cysticercosis of the eye in South India--a case series. (16327117)
2005
50
Prevalence of antibodies to unique Taenia solium oncosphere antigens in taeniasis and human and porcine cysticercosis. (14640505)
2003

Variations for Cysticercosis

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Expression for genes affiliated with Cysticercosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cysticercosis

Search GEO for disease gene expression data for Cysticercosis.

Pathways for genes affiliated with Cysticercosis

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51PathCards, 61Thomson Reuters, 55R&D Systems, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Cysticercosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MIF, TNF
2
Show member pathways
IL27-mediated signaling events39
9.8IL18, TNF
39.8IL18, TNF
49.8IL18, TNF
59.8IL18, TNF
69.8IL18, TNF
79.8IL18, TNF
89.8TNF, IL18

Compounds for genes affiliated with Cysticercosis

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Cysticercosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dextran sulfate sodium4610.3IL18, MIF
2tuberculin4610.2IL18, MIF
3anakinra46 1211.2TNF, IL18
4natalizumab46 1211.2IL18, TNF
5il-124610.1IL18, TNF
6indoleamine4610.1IL18, TNF
7imiquimod46 62 30 1213.1IL18, TNF
8groalpha4610.1TNF, IL18
9gm-csf46 3011.1IL18, TNF
10lipoteichoic acid4610.0IL18, TNF
11levamisole46 1211.0IL18, IGHE
12polyinosinic-polycytidylic acid4610.0IL18, TNF
13etanercept46 52 1211.9IL18, TNF
14poly(i-c)469.9TNF, IL18
15thalidomide46 52 62 1212.9TNF, MIF, IL18
16salbutamol46 52 30 25 1213.9IGHE, IL18
17budesonide46 52 1211.9IGHE, TNF
18endotoxin469.8IL18, MIF, TNF
19curcumin469.8TNF, MIF, IL18
20fluticasone propionate46 52 62 1212.8IGHE, TNF
21il 10469.8TNF, IL18
22rantes469.8TNF, MIF, IL18
23mycophenolate mofetil46 52 1211.8TNF, IL18
24sb 20358046 6210.7IL18, MIF, TNF
25cyclophosphamide46 52 1211.7IGHE, MIF, IL18
26tarc469.7IGHE, TNF, IL18
27nicotine46 30 52 1212.7IGHE, MIF, IL18
28infliximab46 52 1211.7IGHE, TNF, IL18
29hydrocortisone46 3 62 1212.7MIF, TNF, IGHE
30prednisolone46 30 1211.7IL18, TNF, IGHE
31methotrexate52 46 1211.6IGHE, TNF, IL18
32n acetylcysteine469.6IL18, TNF, IGHE
33indomethacin46 30 62 1212.6IL18, TNF, IGHE
34norepinephrine46 25 1211.5IGHE, MIF, IL18
35hydrogen46 2510.4DUT, MT-CO1, MIF, IL18
36histamine46 30 2511.4IL18, TNF, IGHE
37estradiol46 25 1211.4IL18, MIF, SAFB
38lactate469.3IL18, MIF, TNF, IGHE
39thymidine46 2510.3IL18, MIF, DUT, TNF
40dexamethasone46 52 30 1212.3IL18, MIF, TNF, IGHE
41arginine469.3IGHE, SAFB, IL18, SLC5A2
42l-nmma469.3TNF, IGHE
43glucose469.3SAFB, MT-CO1, MIF, IL18, SLC5A2
44vegf469.3IL18, MIF, TNF, IGHE
45oxygen46 2510.3IL18, MIF, MT-CO1, TNF
46alanine469.0TACSTD2, IL18, MIF, SAFB, IGHE
47retinoic acid46 259.9IGHE, TNF, SAFB, MIF, IL18
48allergens468.8RPLP2, IL18, SAFB, IGHE
49serine468.8TNF, DUT, SAFB, MIF, IL18
50estrogen468.8IGHE, SAFB, MIF, IL18

GO Terms for genes affiliated with Cysticercosis

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17Gene Ontology
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Cellular components related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.2MIF, RPLP2, TACSTD2, SLC5A2, DUT
2extracellular regionGO:0055768.0PDCD1LG2, IL18, MIF, TNF, IGHE

Biological processes related to Cysticercosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.0MIF, TNF
2positive regulation of cytokine secretionGO:05071510.0TNF, MIF
3positive regulation of NF-kappaB import into nucleusGO:04234610.0IL18, TNF
4lipopolysaccharide-mediated signaling pathwayGO:0316639.9IL18, TNF
5cellular response to organic cyclic compoundGO:0714079.9IL18, TNF
6positive regulation of interferon-gamma productionGO:0327299.8TNF, IL18
7positive regulation of MAP kinase activityGO:0434069.7TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5MIF, TNF
9inflammatory responseGO:0069549.4IL18, MIF, TNF
10immune responseGO:0069559.0PDCD1LG2, IL18, IGHE

Molecular functions related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL18, MIF, TNF

Products for genes affiliated with Cysticercosis

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Sources for Cysticercosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet