PORK
MCID: CYS005
MIFTS: 63

Cysticercosis (PORK) malady

Rare diseases, Infectious diseases, Gastrointestinal diseases, Neuronal diseases categories
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Summaries for Cysticercosis

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NIH Rare Diseases:42 Cysticercosis is an infectious disorder caused by the pork tapeworm, taenia solium. infection occurs when the tapeworm larvae enter the body and form cysticeri (cysts). the tapeworm eggs are spread through food, water, or other surfaces contaminated with feces. the signs and symptoms vary depending on the location and number of cysticeri in the affected person's body. symptoms can present months to years after the infection. diagnosing cysticercosis can be challenging and may involve several test, including mri or ct brain scans and blood tests. although treatment is available and may include anti-parasitic drugs, anti-inflammatory drugs, and/or surgery, it is not always necessary. last updated: 4/12/2010

MalaCards based summary: Cysticercosis, also known as neurocysticercosis, is related to tuberculosis and taeniasis. An important gene associated with Cysticercosis is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Th1 Differentiation. The drugs albendazole and praziquantel and the compounds dextran sulfate sodium and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are tumorigenesis and cellular.

Disease Ontology:8 A taeniasis that results from ingestion of eggs or larvae of the taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions.

CDC:3 Cysticercosis is a parasitic tissue infection caused by larval cysts of the tapeworm Taenia solium. These larval cysts infect brain, muscle, or other tissue, and are a major cause of adult onset seizures in most low-income countries. A person gets cysticercosis by swallowing eggs found in the feces of a person who has an intestinal tapeworm.  People living in the same household with someone who has a tapeworm have a much higher risk of getting cysticercosis than people who don’t.

Wikipedia:65 Cysticercosis is a tissue infection caused by the pork tapeworm (Taenia solium). People may have little... more...

Aliases & Classifications for Cysticercosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Cysticercosis, Aliases & Descriptions:

Name: Cysticercosis 8 42 10 44 48 62
Neurocysticercosis 8 42 44 62
Intestinal Taenia Solium Infection 8 62
Submacular Cysticercosis 42 62
Pork Tapeworm Infection 8 62
 
Taeniasis 42 62
Tapeworm Infection: Intestinal Taenia Solium 8
Tenia Solium Infectious Disease 8
Pork 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
cysticercosis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:10079
MeSH34 D003551
NCIt39 C34520
ICD9CM27 123.1
MESH via Orphanet35 D003551
ICD10 via Orphanet26 B69.0, B69.1, B69.8 B69.9, more
UMLS via Orphanet63 C0010678
ICD1025 B69, B69.9

Related Diseases for Cysticercosis

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Graphical network of the top 20 diseases related to Cysticercosis:



Diseases related to cysticercosis

Symptoms for Cysticercosis

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Drugs & Therapeutics for Cysticercosis

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Drug clinical trials:

Search ClinicalTrials for Cysticercosis

Search NIH Clinical Center for Cysticercosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cysticercosis

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Anatomical Context for Cysticercosis

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MalaCards organs/tissues related to Cysticercosis:

32
Brain, Testes, Eye, Heart, Skin, Tongue, Spinal cord, Breast, Kidney, Salivary gland, Spleen, Liver, Pancreas, Thyroid, Temporal lobe

Animal Models for Cysticercosis or affiliated genes

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MGI Mouse Phenotypes related to Cysticercosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9TACSTD2, PDCD1LG2, MIF, TNF
2MP:00053848.1TNF, SAFB, MT-CO1, MIF, IL18, TACSTD2
3MP:00053977.8IGHE, TNF, SAFB, MIF, IL18, PDCD1LG2
4MP:00053877.7IGHE, TNF, MT-CO1, MIF, IL18, PDCD1LG2
5MP:00053767.1SLC5A2, IGHE, TNF, SAFB, MT-CO1, MIF

Publications for Cysticercosis

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Articles related to Cysticercosis:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Immunology of Taenia solium taeniasis and human cysticercosis. (24962350)
2014
2
Of pigs and people--WHO prepares to battle cysticercosis. (25136715)
2014
3
Generalized Taenia crassiceps cysticercosis in a chinchilla (Chinchilla lanigera). (24126089)
2014
4
Prevalence of porcine cysticercosis in the Lake Kyoga Basin, Uganda. (25286901)
2014
5
Taenia eggs in a stabilization pond system with poor hydraulics: concern for human cysticercosis? (24355860)
2013
6
Occurrence and factors associated with bovine cysticercosis recorded in cattle at meat inspection in Denmark in 2004-2011. (23245844)
2013
7
Molecular identification of species of Taenia causing bovine cysticercosis in Ethiopia. (23452760)
2013
8
Disseminated cysticercosis. (24197175)
2013
9
Ocular cysticercosis in a 32-year-old man in Abuja: ultrasonic features as an aid in diagnosis. (24348016)
2013
10
Cyscicerci in the longus colli in disseminated cysticercosis: an unusual location for a common endemic disease. (23893275)
2013
11
Isolated brainstem cysticercosis. (23453152)
2013
12
High prevalence of cysticercosis in people with epilepsy in southern Rwanda. (24244783)
2013
13
An epidemiological survey on the determination of Taenia saginata cysticercosis in Iran, using a PCR assay. (23571031)
2013
14
The effect of oxfendazole treatment on muscle pathology in pigs infected with Taenia solium cysticercosis. (22883970)
2012
15
Multifocal cysticercosis with optical coherence tomography findings in a child. (22623867)
2012
16
Taeniasis and cysticercosis due to Taenia solium in Japan. (22248435)
2012
17
Diagnostic epitope variability within Taenia solium 8 kDa antigen family: implications for cysticercosis immunodetection. (22075212)
2012
18
Development and evaluation of flow through assay for detection of antibodies against porcine cysticercosis. (21602782)
2011
19
A dramatic case of intraventricular cysticercosis. (21670411)
2011
20
Cysticercosis of midbrain presenting with fluctuating ptosis. (22028538)
2011
21
Cysticercosis of the temporalis muscle causing temporal headache in a pregnant woman. (21529806)
2011
22
Disseminated cysticercosis. (21556243)
2011
23
Seroprevalence of Taenia saginata cysticercosis in the federal state of Lower Saxony in Germany. (21038810)
2010
24
Racemose cysticercosis in the cerebellar hemisphere. (20717513)
2010
25
Orbital cysticercosis presenting as recurrent periorbital cellulitis in a four-year-old child. (20431389)
2010
26
Intravitreal cysticercosis presenting as neovascular glaucoma. (20029152)
2010
27
Some risk factors for Taenia solium cysticercosis in semi-intensively raised pigs in Zuru, Nigeria. (20391368)
2010
28
Cytomorphological spectrum of subcutaneous and intramuscular cysticercosis: A study of 22 cases. (21157562)
2010
29
Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. (20035822)
2010
30
Development of a biomolecular assay for postmortem diagnosis of Taenia saginata Cysticercosis. (20618079)
2010
31
Cysticercosis: a rare cause of orbital infection. (19476757)
2009
32
Mylohyoid cysticercosis: a rare submandibular mass. (19924665)
2009
33
Seroepidemiologic survey of cysticercosis-taeniasis in four central highland districts of Papua, Indonesia. (19270286)
2009
34
Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis. (19041315)
2009
35
Subconjunctival cysticercosis. (19810391)
2009
36
Subcutaneous and intramuscular cysticercosis: high-resolution sonography. (19736438)
2009
37
Treatment of cerebral cysticercosis with albendazole in elevated dosages. (18392434)
2008
38
Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa. (18440704)
2008
39
Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. (18834668)
2008
40
Cysticercosis in a female Nicaraguan traveler. (17883469)
2007
41
The immune response in Taenia solium cysticercosis: protection and injury. (18042169)
2007
42
Oral cysticercosis: a collaborative study of 16 cases. (17395067)
2007
43
Primary spinal intradural extramedullary cysticercosis. (17719976)
2007
44
A descriptive study of 36 cases of solitary soft tissue cysticercosis at Ramathibodi Hospital from surgical specimens during 1990-2006. (17877213)
2007
45
Usefulness of severe combined immunodeficiency (scid) and inbred mice for studies of cysticercosis and echinococcosis. (16338168)
2006
46
Brief historical remarks as an introduction for the international symposium on taeniasis/cysticercosis and echinococcosis. (16337830)
2006
47
A case of intramuscular cysticercosis diagnosed definitively by mitochondrial DNA analysis of extremely calcified cysts. (16406683)
2006
48
Cysticercosis of the eye in South India--a case series. (16327117)
2005
49
Acquired brown syndrome secondary to superior oblique muscle cysticercosis. (12690365)
2003
50
Prevalence of antibodies to unique Taenia solium oncosphere antigens in taeniasis and human and porcine cysticercosis. (14640505)
2003

Variations for Cysticercosis

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Expression for genes affiliated with Cysticercosis

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Expression patterns in normal tissues for genes affiliated with Cysticercosis

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Pathways for genes affiliated with Cysticercosis

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Pathways related to Cysticercosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MIF, TNF
2
Show member pathways
IL27-mediated signaling events37
9.8IL18, TNF
39.8IL18, TNF
49.8IL18, TNF
59.8IL18, TNF
69.8IL18, TNF
79.8IL18, TNF
89.8TNF, IL18

Compounds for genes affiliated with Cysticercosis

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Compounds related to Cysticercosis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1dextran sulfate sodium4410.3IL18, MIF
2tuberculin4410.2IL18, MIF
3anakinra44 1111.2TNF, IL18
4natalizumab44 1111.2IL18, TNF
5il-124410.1IL18, TNF
6indoleamine4410.1IL18, TNF
7imiquimod44 61 28 1113.1IL18, TNF
8groalpha4410.1TNF, IL18
9gm-csf44 2811.1IL18, TNF
10lipoteichoic acid4410.0IL18, TNF
11levamisole44 1111.0IL18, IGHE
12polyinosinic-polycytidylic acid4410.0IL18, TNF
13etanercept44 50 1111.9IL18, TNF
14poly(i-c)449.9TNF, IL18
15thalidomide44 50 61 1112.9TNF, MIF, IL18
16salbutamol44 50 28 24 1113.9IGHE, IL18
17budesonide44 50 1111.9IGHE, TNF
18endotoxin449.8IL18, MIF, TNF
19curcumin449.8TNF, MIF, IL18
20fluticasone propionate44 50 61 1112.8IGHE, TNF
21il 10449.8TNF, IL18
22rantes449.8TNF, MIF, IL18
23mycophenolate mofetil44 50 1111.8TNF, IL18
24sb 20358044 6110.7IL18, MIF, TNF
25cyclophosphamide44 50 1111.7IGHE, MIF, IL18
26tarc449.7IGHE, TNF, IL18
27nicotine44 28 50 1112.7IGHE, MIF, IL18
28infliximab44 50 1111.7IGHE, TNF, IL18
29hydrocortisone44 2 61 1112.7MIF, TNF, IGHE
30prednisolone44 28 1111.7IL18, TNF, IGHE
31methotrexate50 44 1111.6IGHE, TNF, IL18
32n acetylcysteine449.6IL18, TNF, IGHE
33indomethacin44 28 61 1112.6IL18, TNF, IGHE
34norepinephrine44 24 1111.5IGHE, MIF, IL18
35hydrogen44 2410.4DUT, MT-CO1, MIF, IL18
36histamine44 28 2411.4IL18, TNF, IGHE
37estradiol44 24 1111.4IL18, MIF, SAFB
38lactate449.3IL18, MIF, TNF, IGHE
39thymidine44 2410.3IL18, MIF, DUT, TNF
40dexamethasone44 50 28 1112.3IL18, MIF, TNF, IGHE
41arginine449.3IGHE, SAFB, IL18, SLC5A2
42l-nmma449.3TNF, IGHE
43glucose449.3SAFB, MT-CO1, MIF, IL18, SLC5A2
44vegf449.3IL18, MIF, TNF, IGHE
45oxygen44 2410.3IL18, MIF, MT-CO1, TNF
46alanine449.0TACSTD2, IL18, MIF, SAFB, IGHE
47retinoic acid44 249.9IGHE, TNF, SAFB, MIF, IL18
48allergens448.8RPLP2, IL18, SAFB, IGHE
49serine448.8TNF, DUT, SAFB, MIF, IL18
50estrogen448.8IGHE, SAFB, MIF, IL18

GO Terms for genes affiliated with Cysticercosis

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Cellular components related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.2MIF, RPLP2, TACSTD2, SLC5A2, DUT
2extracellular regionGO:0055768.0PDCD1LG2, IL18, MIF, TNF, IGHE

Biological processes related to Cysticercosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.0MIF, TNF
2positive regulation of cytokine secretionGO:05071510.0TNF, MIF
3positive regulation of NF-kappaB import into nucleusGO:04234610.0IL18, TNF
4lipopolysaccharide-mediated signaling pathwayGO:0316639.9IL18, TNF
5cellular response to organic cyclic compoundGO:0714079.9IL18, TNF
6positive regulation of interferon-gamma productionGO:0327299.8TNF, IL18
7positive regulation of MAP kinase activityGO:0434069.7TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5MIF, TNF
9inflammatory responseGO:0069549.4IL18, MIF, TNF
10immune responseGO:0069559.0PDCD1LG2, IL18, IGHE

Molecular functions related to Cysticercosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.4IL18, MIF, TNF

Products for genes affiliated with Cysticercosis

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Sources for Cysticercosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet