MCID: CYS018
MIFTS: 51

Cystitis malady

Nephrological diseases category
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Summaries for Cystitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that... more...

MalaCards: Cystitis is related to chronic interstitial cystitis and chronic cystitis. An important gene associated with Cystitis is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways is Neuroscience. The drugs mesna and carboprost and the compounds pgj-2 and hcec have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and bone marrow, and related mouse phenotype growth/size/body.

Aliases & Classifications for Cystitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

cystitis 8 10 45 62


External Ids:

Disease Ontology8 DOID:1679
ICD9CM27 595, 595.9
NCIt40 C26738
MeSH35 D003556
ICD1025 N30, N30.9

Related Diseases for Cystitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1chronic interstitial cystitis31.1SPRR2G, HBEGF, TSPO
2chronic cystitis31.1PTGS1, NGF
3pyelonephritis30.8NAGLU, UMOD
4eosinophilia30.2NGF, RNASE3
5pneumonia30.0NAGLU, PTGS1
6urinary tract obstruction30.0HBEGF, NAGLU, UMOD
7rheumatoid arthritis30.0HBEGF, TSPO, PTGS1, NAGLU, RNASE3
8diabetes mellitus29.9UMOD, NAGLU, NGF
9asthma29.9NGF, HBEGF, RNASE3, TSPO, PTGS1
10leukemia29.9RNASE3, NGF, PTGS1, HBEGF, GAP43
11chronic pyelonephritis29.8NAGLU, UMOD
12vesicoureteral reflux29.8NAGLU, UMOD
13eosinophilic cystitis10.9
14paine syndrome10.9
15acute cystitis10.8
16hemorrhagic cystitis10.8
17radiation cystitis10.7
18cystitis cystica10.7
19pyelitis10.5
20prostatitis10.5
21urethritis10.5
22hematopoietic stem cell transplantation10.5
23bacteriuria10.4
24pelvic lipomatosis10.4
25lipomatosis10.3
26urethral syndrome10.3
27acute pyelonephritis10.3
28adenocarcinoma10.3
29blindness10.2
30glandular cystitis10.2
31proctitis10.2
32acute gonococcal cystitis10.2
33neurogenic bladder10.2
34lupus erythematosus10.2
35nephrogenic adenoma10.1
36neuronitis10.1
37systemic lupus erythematosus10.1
38diphtheritic cystitis10.1
39adenoma10.1
40bladder carcinoma10.1
41tuberculosis10.1
42vaginitis10.1
43malakoplakia10.1
44keratoconjunctivitis10.1RNASE3
45arthritis10.1
46bladder disease10.1
47cervicitis10.1
48urethral obstruction10.1
49urethral stricture10.1
50hypereosinophilic syndrome10.1

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to cystitis

Symptoms for Cystitis

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Drugs & Therapeutics for Cystitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cystitis

Search NIH Clinical Center for Cystitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cystitis

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Anatomical Context for Cystitis

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33MalaCards
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MalaCards organs/tissues related to Cystitis:

33
Kidney, Prostate, Bone marrow, Bone, Spinal cord, Endothelial, Testes, B cells, Skin, Pituitary, Colon, Uterus, Thyroid, Heart, Breast

Animal Models for Cystitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Cystitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.2GAP43, UMOD, NAGLU, PTGS1, HBEGF, NGF

Publications for Cystitis

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52PubMed
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Articles related to Cystitis:

(show top 50)    (show all 977)
idTitleAuthorsYear
1
SjAPgren's syndrome accompanied with interstitial cystitis: a case report and review of the literature. (24395198)
2014
2
Coexistence of inflammatory pseudotumour and pseudomembranous cystitis: a histopathological surprise. (24395867)
2014
3
Risk factors and predictors of severity score and complications of pediatric hemorrhagic cystitis. (23954584)
2014
4
Computed tomography scan in supine and prone positions: an alternative method to detect intramural gas in emphysematous cystitis and to evaluate efficacy after adjuvant continuous intravesical irrigation treatment. (23148785)
2013
5
Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. (23485788)
2013
6
Eosinophilic cystitis presented as a manifestation of hypereosinophilic syndrome: a case report and review of the literature. (23573073)
2013
7
Interleukin-6 levels in female rats with protamine sulfate-induced chronic cystitis treated with hyaluronic acid. (23379983)
2013
8
Intravesical heparin: interstitial cystitis (painful bladder syndrome). (24421434)
2013
9
Cystectomy for ulcerative interstitial cystitis: sequelae and patients' perceptions of improvement. (24074977)
2013
10
Elimination of Hunner's Ulcers by Fulguration in Patients With Interstitial Cystitis: Is It Effective and Long Lasting? (24255759)
2013
11
Effects of Tadalafil on Hemorrhagic Cystitis and Testicular Dysfunction Induced by Cyclophosphamide in Rats. (24051982)
2013
12
Nationwide surveillance of bacterial pathogens from patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2009 and 2010: antimicrobial susceptibility of Escherichia coli and Staphylococcus saprophyticus. (23640203)
2013
13
A case of eosinophilic cystitis in patients with abdominal pain, dysuria, genital skin hyperemia and slight toxocariasis. (23820659)
2013
14
BK virus encephalitis without concurrent hemorrhagic cystitis in an allogeneic hematopoietic stem cell transplant recipient. (24086945)
2013
15
Ketamine cystitis: an emerging diagnostic and therapeutic challenge. (23124288)
2012
16
Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. (21904840)
2012
17
Genotypic Analysis of E. coli Strains Isolated from Patients with Cystitis and Pyelonephritis. (22997556)
2012
18
Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium. (22700375)
2012
19
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? (23030327)
2012
20
Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model. (22546378)
2012
21
Mapping of pain phenotypes in female patients with bladder pain syndrome/interstitial cystitis and controls. (22633363)
2012
22
Polyomavirus BK: possibly associated skin eruption in a patient with hemorrhagic cystitis. (21276065)
2011
23
Clinical features of lupus cystitis complicated with hydroureteronephrosis in a Chinese population. (21239742)
2011
24
Editorial comment to effect of hyaluronic acid on urine nerve growth factor in cyclophosphamide-induced cystitis. (21699581)
2011
25
AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. (21497847)
2011
26
Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis. (21194324)
2011
27
Trimethoprim-sulfamethoxazole may no longer be acceptable for the treatment of acute uncomplicated cystitis in the United States. (21765092)
2011
28
Eosinophilic cystitis associated with eosinophilic enterocolitis: case reports and review of the literature. (20505026)
2010
29
Penicillin G-induced hemorrhagic cystitis with hydronephrosis. (19755771)
2009
30
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. (18957084)
2008
31
CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. (17149610)
2007
32
Is there a relation between urinary interleukin-6 levels and symptoms before and after intra-vesical glycosaminoglycan substitution therapy in patients with bladder pain syndrome/interstitial cystitis? (17982709)
2007
33
Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity. (16890679)
2006
34
Giant botryoid fibroepithelial polyp of bladder with myofibroblastic stroma and cystitis cystica et glandularis. (12574920)
2003
35
Bladder neck obstruction due to bilharzial cystitis as a cause of renal failure in Aden City. (14612029)
2003
36
Antibiotic treatment for five days is effective in children with acute cystitis. (11883819)
2002
37
Eosinophilic cystitis in adults. (11176473)
2001
38
Eosinophilic cystitis in view of two cases. (10935134)
1999
39
Eosinophilic cystitis following an infected urachal remnant. (10369914)
1999
40
Fluoroquinolone use for acute cystitis in an IPA-model managed care organization. (8601266)
1995
41
Eosinophilic cystitis caused by vesical sparganosis: a case report. (8437270)
1993
42
Cyclophosphamide-induced hemorrhagic pyelitis and ureteritis associated with cystitis in marrow transplantation. (2231904)
1990
43
Vaginal discharge and cystitis. (3399160)
1988
44
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
45
Single dose trimethoprim-sulfamethoxazole in acute cystitis. (6413899)
1983
46
A new citrated formulation of nalidixic acid (Mictral U.K.) for the treatment of acute cystitis. (7016625)
1981
47
Chronic interstitial cystitis. (5159574)
1971
48
Psychometric testing with the human figure drawing in chronic cystitis. (5532923)
1970
49
Surgical treatment of chronic cystitis in a bitch. (5812943)
1969
50
Remarks on a New Mode of Affording Permanent Relief to Intractable Chronic Cystitis, and to Confirmed Prostatic Retention of Urine. (20750395)
1882

Variations for Cystitis

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Expression for genes affiliated with Cystitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for genes affiliated with Cystitis

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50PathCards, 5Cell Signaling Technology
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Pathways related to Cystitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4GAP43, PTGS1, NGF

Compounds for genes affiliated with Cystitis

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Cystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1pgj-24510.2PTGS1, NGF
2hcec4510.1HBEGF, NGF
3lte44510.1RNASE3, PTGS1
411-dehydrothromboxane b24510.1RNASE3, PTGS1
5zafirlukast45 29 1112.1RNASE3, PTGS1
6calcium oxalate459.9UMOD, NAGLU
7eszopiclone45 1110.9TSPO, PTGS1
8zopiclone45 1110.9PTGS1, TSPO
9oxalate459.9UMOD, NAGLU
10montelukast45 51 29 1112.8RNASE3, PTGS1
11zolpidem29 45 24 1112.8PTGS1, TSPO
12diphenhydramine45 29 3 24 1113.8TSPO, PTGS1
13zymosan459.7RNASE3, NAGLU
14phorbol459.7RNASE3, HBEGF, GAP43
15choline45 24 1111.7NGF, PTGS1, GAP43
16sulfate45 2410.7NAGLU, UMOD, HBEGF
17latex459.6NAGLU, HBEGF, RNASE3
18txb2459.6PTGS1, NAGLU, RNASE3
19ltc4459.6PTGS1, RNASE3
20aspirin45 51 29 2412.6PTGS1, NGF, RNASE3
21uric acid45 2410.6RNASE3, NAGLU, UMOD
22urea45 24 1111.5NAGLU, UMOD, RNASE3
23theophylline45 29 24 1112.5NGF, TSPO, RNASE3
24hyaluronic acid45 2410.5PTGS1, RNASE3, NAGLU
25polysaccharide459.5RNASE3, HBEGF, NGF, UMOD
26vitamin a45 24 1111.4HBEGF, GAP43, NAGLU
27cocaine45 1110.4NGF, GAP43, TSPO
28agar459.4PTGS1, HBEGF, TSPO
2912-o-tetradecanoylphorbol 13-acetate459.4GAP43, HBEGF, NGF
30cycloheximide459.4GAP43, NGF, HBEGF, PTGS1
31n acetylcysteine459.3HBEGF, RNASE3, NAGLU
32vegf459.2PTGS1, NGF, RNASE3, HBEGF
33dbc-amp459.2RNASE3, GAP43, NAGLU, NGF
34indomethacin45 29 61 1112.2TSPO, PTGS1, NGF
35nmda45 2910.2GAP43, PTGS1, NGF, TSPO
36acetylcholine45 51 29 24 1113.1TSPO, GAP43, RNASE3, NGF
37dexamethasone45 51 29 1112.1NGF, HBEGF, PTGS1, RNASE3, GAP43
38isoflurane51 45 1111.0TSPO, NAGLU
39cyclosporin a45 29 6111.0TSPO, NAGLU, RNASE3, NGF
40valproic acid45 51 24 1112.0NAGLU, GAP43, TSPO, PTGS1
41dopamine45 29 24 1112.0NAGLU, NGF, TSPO, GAP43
42alanine458.9NAGLU, PTGS1, HBEGF, NGF, GAP43
43nitric oxide45 24 1110.9NAGLU, HBEGF, RNASE3, GAP43, PTGS1
44heparin45 29 24 1111.9NAGLU, RNASE3, UMOD, HBEGF, GAP43
45glutamate458.9GAP43, TSPO, NGF, HBEGF, PTGS1
46steroid458.7TSPO, GAP43, NAGLU, RNASE3
47creatinine458.7RNASE3, TSPO, NAGLU, NGF, UMOD
48cysteine458.6PTGS1, HBEGF, NAGLU, UMOD, NGF, GAP43
49calcium45 51 24 1111.4GAP43, UMOD, RNASE3, NAGLU, NGF, HBEGF
50h2o2458.3PTGS1, GAP43, TSPO, RNASE3, NAGLU, HBEGF

GO Terms for genes affiliated with Cystitis

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Products for genes affiliated with Cystitis

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Sources for Cystitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet