MCID: CYS018
MIFTS: 46

Cystitis malady

Nephrological category

Summaries for Cystitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that... more...

MalaCards: Cystitis is related to chronic interstitial cystitis and bladder carcinoma. An important gene associated with Cystitis is HBEGF (heparin-binding EGF-like growth factor). The drugs ciprofloxacin and methenamine and the compounds txb2 and heparin have been mentioned in the context of this disorder. Related mouse phenotype integument.

Aliases & Classifications for Cystitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

cystitis 8 10 45 61


External Ids:

Disease Ontology8 DOID:1679
ICD9CM27 595, 595.9
MeSH35 D003556
NCIt40 C26738
ICD1025 N30, N30.9

Related Diseases for Cystitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cystitis family:

acute cystitis chronic cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1chronic interstitial cystitis31.1CKAP4, FZD8, ZDHHC2, HBEGF, P2RX3, NME1-NME2
2bladder carcinoma30.6HBEGF, KRT20
3adenocarcinoma30.3TSPO, PTGS1, KRT20, TAC1, HBEGF
4pain disorder30.3TAC1, NGF
5arthritis30.1TAC1, PTGS1
6asthma30.1NGF, HBEGF, RNASE3, IL11, TAC1, PTGS1
7urinary tract obstruction29.9NAGLU, HBEGF, UMOD
8panic disorder29.9TSPO, NAGLU
9bladder transitional cell carcinoma29.9PTGS1, KRT20
10fibromyalgia29.7TSPO, TAC1
11bronchiolitis29.7RNASE3, IL11
12colorectal cancer29.7PTGS1, KRT20
13pulmonary disease, chronic obstructive29.7TSPO, PTGS1, TAC1, RNASE3
14eosinophilic cystitis10.9
15acute cystitis10.9
16radiation cystitis10.7
17cystitis cystica10.7
18glandular cystitis10.7
19n syndrome10.5
20chronic pain10.5
21hematopoietic stem cell transplantation10.4
22bacteriuria10.4
23pelvic lipomatosis10.3
24urethral syndrome10.3
25acute pyelonephritis10.3
26urethritis10.2
27neurogenic bladder10.2
28bladder adenocarcinoma10.2
29proctitis10.2
30acute gonococcal cystitis10.2
31bladder disease10.2
32radiation proctitis10.2
33nephrogenic adenoma10.1
34systemic lupus erythematosus10.1
35diphtheritic cystitis10.1
36adenoma10.1
37tuberculosis10.1
38malakoplakia10.1
39mast syndrome10.1
40prostatic cyst10.1
41bladder lymphoma10.1
42urethral obstruction10.1
43urethral stricture10.1
44char syndrome10.1
45hypereosinophilic syndrome10.1
46urachal cyst10.1
47neuroblastoma10.0NGF
48glioblastoma multiforme10.0NGF, HBEGF, TAC1, TSPO
49gastritis10.0PTGS1, HBEGF
50pancreatitis10.0TAC1, IL11

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to cystitis

Clinical Features for Cystitis

Drugs & Therapeutics for Cystitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cystitis

Drug clinical trials:

Search ClinicalTrials for Cystitis

Search NIH Clinical Center for Cystitis

Search CenterWatch for Cystitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cystitis

Anatomical Context for Cystitis

Animal Models for Cystitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Cystitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5P2RX3, TAC1, NAGLU, HBEGF

Publications for Cystitis

Sources:
51PubMed
See all sources

Articles related to Cystitis:

(show top 50)    (show all 989)
idTitleAuthorsYear
1
Computed tomography scan in supine and prone positions: an alternative method to detect intramural gas in emphysematous cystitis and to evaluate efficacy after adjuvant continuous intravesical irrigation treatment. (23148785)
2013
2
Effect of amitriptyline in treatment interstitial cystitis or bladder pain syndrome according to two criteria: Does ESSIC criteria change the response rate? (23744795)
2013
3
Xanthogranulomatous cystitis: a case report and clinicopathological review. (23842772)
2013
4
Re: Toll-like 4 receptor variant, Asp299Gly, and reduced risk of hemorrhagic cystitis after hematopoietic stem cell transplantation. (24209529)
2013
5
Effects of vitamin D analog on bladder function and sensory signaling in animal models of cystitis. (23374845)
2013
6
Basic research: Toxic cations could be the root cause of interstitial cystitis. (24366346)
2013
7
Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. (24035333)
2013
8
A case of almost painless herpes zoster presenting with symptoms of cystitis, penile numbness, and acute vestibular failure. (24251046)
2013
9
Local immune response in bladder pain syndrome/interstitial cystitis ESSIC type 3C. (23670165)
2013
10
Reduction of intercellular adhesion molecule 1 may play a role in anti-inflammatory effect of hyaluronic acid in a rat model of severe non-bacterial cystitis. (22358112)
2013
11
Risk factors for recurrent cystitis following acute cystitis in female patients. (23380970)
2013
12
Follow-up protein profiles in urine samples during the course of obstructive feline idiopathic cystitis. (24257070)
2013
13
Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitis. (23421394)
2013
14
Recurrent cystitis in post-menopausal patients more or less than 65 years of age. (23619287)
2013
15
Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome/interstitial cystitis. (23253961)
2013
16
Intravesical glycosaminoglycans for obstructive feline idiopathic cystitis: a pilot study. (24196569)
2013
17
Re: Continuous intravesical lidocaine treatment for interstitial cystitis/bladder pain syndrome: safety and efficacy of a new drug delivery device. (23663606)
2013
18
Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats. (23716886)
2013
19
Re: Hepner et al.: suicidal ideation among patients with bladder pain syndrome/interstitial cystitis. (Urology 2012;80:280-285). (23021673)
2012
20
Sacral neuromodulation is an effective treatment for interstitial cystitis/bladder pain syndrome: con. (23000858)
2012
21
Unusual case of severe late-onset cytomegalovirus-induced hemorrhagic cystitis and ureteritis in a renal transplant patient. (22251223)
2012
22
Hyperbaric oxygen therapy for radiation-induced cystitis and proctitis. (22440041)
2012
23
MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models. (23049171)
2012
24
BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. (22432050)
2012
25
Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis. (22297664)
2012
26
A case of emphysematous cystitis. (22576409)
2012
27
Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: implication for the pathogenesis of interstitial cystitis/bladder pain syndrome. (22353309)
2012
28
Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice. (22646666)
2012
29
Polyomavirus BK: possibly associated skin eruption in a patient with hemorrhagic cystitis. (21276065)
2011
30
Editorial comment to effect of hyaluronic acid on urine nerve growth factor in cyclophosphamide-induced cystitis. (21699581)
2011
31
Encrusting cystitis due to Corynebacterium urealyticum in a patient with ANCA-associated vasculitis: case report and review of the literature. (21277617)
2011
32
Numbers and types of nonbladder syndromes as risk factors for interstitial cystitis/painful bladder syndrome. (21295246)
2011
33
ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. (21396778)
2011
34
Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome: a case control study. (22154637)
2011
35
Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis? (20936157)
2010
36
Family history and risk of recurrent cystitis and pyelonephritis in women. (20639019)
2010
37
Recurrent neutrophilic panniculitis secondary to bacterial cystitis. (17324837)
2007
38
Keratin expression profiling of transitional epithelium in the painful bladder syndrome/interstitial cystitis. (16482998)
2006
39
Eosinophilic cystitis presenting as a recurrent symptomatic bladder mass following intravesical mitomycin C therapy. (11912421)
2002
40
Spontaneous bladder rupture due to chronic cystitis 20 years after cystolithotomy. (12444296)
2002
41
'Telephone treatment' of uncomplicated acute cystitis. (10486997)
1999
42
A fatal case of severe haemorrhagic cystitis associated with malakoplakia. (7827856)
1994
43
Hyperbaric oxygen therapy in hemorrhagic radiation cystitis: a report of 20 cases. (7950806)
1994
44
Traditional acupuncture and electrical stimulation of the posterior tibial nerve. A trial in chronic interstitial cystitis. (8493470)
1993
45
Isolation of a nicotinamide-requiring clone of Escherichia coli O18:K1:H7 from women with acute cystitis: resemblance to strains found in neonatal meningitis. (8095816)
1993
46
Eosinophilic cystitis in children. (2038790)
1991
47
A light and electron microscopic study of urothelium from patients with chronic cystitis. (6479201)
1984
48
Eosinophilic cystitis. (7028355)
1981
49
Toxocara antibodies in eosinophilic cystitis. (4970008)
1968
50
Chronic interstitial cystitis. (13832744)
1960

Genetic Variations for Cystitis

Expression for genes affiliated with Cystitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for genes affiliated with Cystitis

Compounds for genes affiliated with Cystitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Cystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1txb24510.9NAGLU, RNASE3, IL11, PTGS1
2heparin45 29 11 2413.9TAC1, UMOD, GAP43, HBEGF, NAGLU, RNASE3
3h2o24510.9GAP43, HBEGF, NAGLU, RNASE3, TAC1, PTGS1
4dbc-amp4510.9RNASE3, NAGLU, NGF, GAP43
5acetylcholine45 50 29 11 2414.9GAP43, NGF, RNASE3, TAC1, P2RX3, TSPO
6theophylline45 29 11 2413.9NGF, RNASE3, TAC1, TSPO
7nitric oxide45 11 2412.9GAP43, HBEGF, NAGLU, RNASE3, IL11, TAC1
8dexamethasone45 50 29 1113.9GAP43, HBEGF, RNASE3, TAC1
9cysteine4510.9UMOD, GAP43, NGF, HBEGF, NAGLU, IL11
10hyaluronic acid45 2411.9NAGLU, RNASE3, IL11, KRT20, PTGS1
11capsaicin45 2911.9NGF, RNASE3, TAC1, P2RX3
12valproic acid45 50 11 2413.9GAP43, NAGLU, PTGS1, TSPO
13phorbol4510.9NME2, RNASE3, HBEGF, GAP43
14nmda45 2911.9GAP43, NGF, TAC1, PTGS1, TSPO
15indomethacin45 60 29 1113.9NGF, IL11, TAC1, PTGS1, TSPO
16dopamine45 29 11 2413.9GAP43, NGF, NAGLU, IL11, TAC1, TSPO
17estrogen4510.9TAC1, RNASE3
18calcium45 50 11 2413.9UMOD, FZD8, GAP43, NGF, HBEGF, NAGLU
19budesonide45 50 1112.9PTGS1, IL11, RNASE3
20histamine45 29 2412.9NGF, RNASE3, IL11, TAC1, TSPO
21ifosfamide45 1111.9NAGLU, IL11, PTGS1
22carbachol45 29 1112.9GAP43, NGF, IL11, TAC1
23cyclosporin a45 29 6012.8NGF, NAGLU, RNASE3, IL11, TSPO
24vegf4510.8NGF, HBEGF, RNASE3, IL11, KRT20, PTGS1
256-hydroxydopamine4510.8TAC1, NGF, GAP43
26steroid4510.8TSPO, TAC1, IL11, RNASE3, NAGLU, GAP43
27mptp4510.8NGF, TAC1, TSPO
28glutamate4510.8GAP43, NGF, HBEGF, TAC1, PTGS1, TSPO
29alanine4510.8GAP43, NGF, HBEGF, NAGLU, IL11, PTGS1
30creatinine4510.8UMOD, NGF, NAGLU, RNASE3, TSPO
31resiniferatoxin45 2911.8P2RX3, TAC1
32tyrosine4510.8GAP43, NGF, HBEGF, RNASE3, IL11, TAC1
33aspartate4510.8GAP43, NAGLU, IL11, TAC1, PTGS1
34epinephrine45 11 2412.8NGF, RNASE3, IL11, TAC1
35propranolol45 29 50 11 2414.8TSPO, TAC1, NGF
36cycloheximide4510.8GAP43, NGF, HBEGF, IL11, PTGS1
37cyclic amp45 2411.8GAP43, NGF, HBEGF, IL11, TAC1
38eszopiclone45 1111.7PTGS1, TSPO
39pgj-24510.7NGF, PTGS1
40zopiclone45 1111.7PTGS1, TSPO
4112-o-tetradecanoylphorbol 13-acetate4510.7GAP43, NGF, HBEGF, IL11
42lte44510.7PTGS1, RNASE3
43uric acid45 2411.7RNASE3, UMOD
44calcium oxalate4510.6UMOD, NAGLU
45polysaccharide4510.6RNASE3, HBEGF, NGF, UMOD
46levodopa45 1111.5NGF, TAC1, TSPO
47vitamin d4510.5PTGS1, IL11, NAGLU, NGF
48ethanol45 50 11 2413.5P2RX3, IL11, RNASE3, GAP43
4911-dehydrothromboxane b24510.4RNASE3, PTGS1
50nedocromil sodium4510.2RNASE3, TAC1

GO Terms for genes affiliated with Cystitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Cystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1behavioral response to painGO:04826610.5TSPO, P2RX3

Products for genes affiliated with Cystitis

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  • Lysates
  • Antibodies

Sources for Cystitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet