MCID: CYS018
MIFTS: 54

Cystitis malady

Nephrological diseases category

Summaries for Cystitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that... more...

MalaCards: Cystitis is related to chronic cystitis and chronic interstitial cystitis. An important gene associated with Cystitis is HBEGF (heparin-binding EGF-like growth factor). The drugs mesna and carboprost and the compounds txb2 and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and bone marrow, and related mouse phenotype integument.

Aliases & Classifications for Cystitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

cystitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:1679
ICD9CM27 595, 595.9
MeSH34 D003556
NCIt39 C26738
ICD1025 N30, N30.9

Related Diseases for Cystitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1chronic cystitis31.2NGF, PTGS1
2chronic interstitial cystitis31.1TSPO, SPRR2G, NME2, NME1-NME2, P2RX3, HBEGF
3bladder carcinoma30.5HBEGF, KRT20
4adenocarcinoma30.3KRT20, TSPO, TAC1, HBEGF, PTGS1
5pain disorder30.3NGF, TAC1
6arthritis30.0TAC1, PTGS1
7rheumatoid arthritis30.0TSPO, TAC1, PTGS1, IL11, HBEGF, RNASE3
8urinary tract obstruction29.9UMOD, HBEGF, NAGLU
9pneumonia29.9PTGS1, IL11, NAGLU
10asthma29.9RNASE3, HBEGF, TSPO, NGF, TAC1, IL11
11chronic pyelonephritis29.9UMOD, NAGLU
12leukemia29.9IL11, PTGS1, RNASE3, HBEGF, NGF, GAP43
13panic disorder29.9NAGLU, TSPO
14diabetes mellitus29.9TAC1, NAGLU, NGF, UMOD
15bladder transitional cell carcinoma29.9PTGS1, KRT20
16pancreatitis29.7TAC1, IL11
17bronchiolitis29.7RNASE3, IL11
18colorectal cancer29.7KRT20, PTGS1
19breast cancer29.7NGF, NME2, TAC1, HBEGF, KRT20
20acute cystitis10.8
21radiation cystitis10.7
22cystitis cystica10.7
23prostatitis10.5
24pyelitis10.5
25pyelonephritis10.5
26urethritis10.4
27bacteriuria10.3
28pelvic lipomatosis10.3
29urethral syndrome10.3
30glandular cystitis10.3
31lipomatosis10.3
32acute pyelonephritis10.3
33neurogenic bladder10.2
34bladder adenocarcinoma10.2
35eosinophilic cystitis10.2
36proctitis10.2
37acute gonococcal cystitis10.2
38bladder disease10.2
39eosinophilia10.2
40lupus erythematosus10.2
41nephrogenic adenoma10.1
42systemic lupus erythematosus10.1
43neuronitis10.1
44diphtheritic cystitis10.1
45adenoma10.1
46tuberculosis10.1
47vaginitis10.1
48bladder lymphoma10.0
49cervicitis10.0
50urethral obstruction10.0

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to cystitis

Clinical Features for Cystitis

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Drugs & Therapeutics for Cystitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cystitis

Drug clinical trials:

Search ClinicalTrials for Cystitis

Search NIH Clinical Center for Cystitis

Search CenterWatch for Cystitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cystitis

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Anatomical Context for Cystitis

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32MalaCards
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MalaCards organs/tissues related to Cystitis:

32
Kidney, Prostate, Bone marrow, Bone, Spinal cord, Endothelial, Testes, B cells, Skin, Pituitary, Colon, Uterus, Thyroid, Heart, Breast

Animal Models for Cystitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5P2RX3, TAC1, NAGLU, HBEGF

Publications for Cystitis

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50PubMed
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Articles related to Cystitis:

(show top 50)    (show all 987)
idTitleAuthorsYear
1
Intravesical heparin: interstitial cystitis (painful bladder syndrome). (24421434)
2013
2
Cystectomy for ulcerative interstitial cystitis: sequelae and patients' perceptions of improvement. (24074977)
2013
3
BK virus (BKV) plasma dynamics in patients with BKV-associated hemorrhagic cystitis following allogeneic stem cell transplantation. (23473059)
2013
4
Nitric oxide modulates bladder afferent nerve activity in the in vitro urinary bladder-pelvic nerve preparation from rats with cyclophosphamide induced cystitis. (23063886)
2013
5
Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons. (23636721)
2013
6
Effectiveness of intravesical hyaluronic acid with or without chondroitin sulfate for recurrent bacterial cystitis in adult women: a meta-analysis. (23129247)
2013
7
A multicentre, prospective, randomised, double-blind study to measure the treatment effectiveness of abobotulinum A (AboBTXA) among women with refractory interstitial cystitis/bladder pain syndrome. (24276074)
2013
8
A C-type lectin receptor pathway is responsible for the pathogenesis of acute cyclophosphamide-induced cystitis in mice. (24102807)
2013
9
Is there a high incidence of hysterectomy and other nonbladder surgeries before and after onset of interstitial cystitis/bladder pain syndrome? (23092763)
2013
10
Mapping of pain phenotypes in female patients with bladder pain syndrome/interstitial cystitis and controls. (22633363)
2012
11
Effects of exogenous glycosaminoglycans on the histological structure of the rat bladder in experimental cystitis. (23330103)
2012
12
Effects of combination treatment of intravesical resiniferatoxin instillation and hydrodistention in patients with refractory painful bladder syndrome/interstitial cystitis: a pilot study. (22500253)
2012
13
Enterococcus faecium related emphysematous cystitis and bladder rupture. (23289047)
2012
14
Admissions related to interstitial cystitis in Japan: an estimation based on the Japanese diagnosis procedure combination database. (22044558)
2012
15
Emphysematous cystitis after surgery for rectal cancer. (22964194)
2012
16
Reinforcements arrive for the war against chronic cystitis and bladder cancer. (22882427)
2012
17
Glandular cystitis and lithium intoxication in a patient with bipolar disorder. (22796915)
2012
18
Management of interstitial cystitis/bladder pain syndrome: a urology perspective. (22877722)
2012
19
Cystitis, pyelonephritis and perinephric abscess due to ureaplasma urealyticum. (23000853)
2012
20
Assessment of cystitis glandularis by transvaginal sonography in women. (22733851)
2012
21
Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. (22082303)
2012
22
Emphysematous cystitis: report of an atypical case. (22606608)
2011
23
BK Virus Associated Late Onset Haemorrhagic Cystitis After Allogeneic Peripheral Blood Stem Cell Transplant. (22942570)
2011
24
Ketamine-snorting associated cystitis. (22248834)
2011
25
Cystitis: symptomatology in women with suspected uncomplicated urinary tract infection. (21671766)
2011
26
Emphysematous cystitis in a patient with type-2 diabetes mellitus. (21847457)
2011
27
Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence. (21592255)
2011
28
Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. (20719340)
2010
29
Antimicrobial resistance among uropathogens that cause acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008. (19446980)
2010
30
Genotypic characterization of virulence factors in Escherichia coli strains from patients with cystitis. (18949339)
2008
31
Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells. (18951569)
2008
32
Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis. (17698128)
2007
33
Clinical manifestations and functional outcomes in children with eosinophilic cystitis. (16280840)
2005
34
Hypereosinophilic syndrome presenting with eosinophilic colitis, enteritis and cystitis. (16246232)
2005
35
Antibiotic treatment for five days is effective in children with acute cystitis. (12641137)
2003
36
Development of collagenous colitis in a cecoplasty of a patient with interstitial cystitis. (8714285)
1996
37
Re: Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder. (1569691)
1992
38
Alkaline-encrusted pyelitis/cystitis and urinary tract infection due to corynebacterium urealyticum: a new severe complication after renal transplantation. (1539352)
1992
39
Eosinophilic cystitis in a renal allograft recipient. (2374203)
1990
40
Chronic interstitial cystitis. (2862324)
1985
41
Cystitis cystica simulating bladder tumor at sonography. (3920259)
1985
42
Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. (3872946)
1985
43
Eosinophilic cystitis in children: a self-limited process. (6427481)
1984
44
Antibacterial therapy for women with abacterial cystitis (urethral syndrome) (6346159)
1983
45
Chronic interstitial cystitis as an initial major manifestation of systemic lupus erythematosus. (6975827)
1981
46
Secretory immunoglobulin-A excretion in cystitis cystica. (4588626)
1973
47
Clinico-pathological conference: cellulitis, urolithiasis, chronic pyelonephritis, chronic cystitis and chronic prostatitis and cystic hyperplasia in a dog. (5104482)
1971
48
Haemorrhagic radiation cystitis. (5678172)
1968
49
Is cystitis cystica an innocent or a malefic lesion? (13281875)
1955
50
Persistence of cystitis after nephrectomy for renal tuberculosis. (14789500)
1950

Genetic Variations for Cystitis

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Expression for genes affiliated with Cystitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for genes affiliated with Cystitis

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Compounds for genes affiliated with Cystitis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Cystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1txb24410.9PTGS1, NAGLU, RNASE3, IL11
2heparin44 28 11 2413.9NAGLU, IL11, RNASE3, HBEGF, GAP43, UMOD
3h2o24410.9GAP43, NAGLU, TAC1, PTGS1, TSPO, RNASE3
4dbc-amp4410.9NGF, GAP43, NAGLU, RNASE3
5acetylcholine44 49 28 11 2414.9TSPO, GAP43, NGF, TAC1, P2RX3, RNASE3
6theophylline44 28 11 2413.9NGF, RNASE3, TAC1, TSPO
7nitric oxide44 11 2412.9TAC1, PTGS1, GAP43, NAGLU, IL11, P2RX3
8dexamethasone44 49 28 1113.9HBEGF, RNASE3, TAC1, GAP43
9cysteine4410.9PTGS1, UMOD, TAC1, IL11, GAP43, NGF
10hyaluronic acid44 2411.9KRT20, PTGS1, IL11, NAGLU, RNASE3
11capsaicin44 2811.9P2RX3, TAC1, RNASE3, NGF
12valproic acid44 49 11 2413.9GAP43, NAGLU, TSPO, PTGS1
13phorbol4410.9NME2, HBEGF, GAP43, RNASE3
14nmda44 2811.9GAP43, NGF, TAC1, PTGS1, TSPO
15indomethacin44 59 28 1113.9NGF, TSPO, TAC1, PTGS1, IL11
16dopamine44 28 11 2413.9NAGLU, NGF, GAP43, TAC1, IL11, TSPO
17estrogen4410.9TAC1, RNASE3
18calcium44 49 11 2413.9UMOD, P2RX3, TAC1, IL11, RNASE3, NAGLU
19budesonide44 49 1112.9PTGS1, RNASE3, IL11
20histamine44 28 2412.9TSPO, NGF, TAC1, IL11, RNASE3
21ifosfamide44 1111.9IL11, PTGS1, NAGLU
22carbachol44 28 1112.9TAC1, NGF, GAP43, IL11
23cyclosporin a44 28 5912.8RNASE3, NGF, IL11, TSPO, NAGLU
24vegf4410.8RNASE3, HBEGF, NGF, PTGS1, IL11, KRT20
256-hydroxydopamine4410.8TAC1, GAP43, NGF
26steroid4410.8TSPO, TAC1, GAP43, IL11, RNASE3, NAGLU
27mptp4410.8NGF, TAC1, TSPO
28glutamate4410.8TSPO, PTGS1, TAC1, HBEGF, NGF, GAP43
29alanine4410.8GAP43, IL11, HBEGF, PTGS1, NGF, NAGLU
30creatinine4410.8NGF, NAGLU, RNASE3, TSPO, UMOD
31resiniferatoxin44 2811.8TAC1, P2RX3
32tyrosine4410.8KRT20, GAP43, IL11, NME2, TAC1, NGF
33aspartate4410.8GAP43, PTGS1, NAGLU, TAC1, IL11
34epinephrine44 11 2412.8NGF, TAC1, IL11, RNASE3
35propranolol44 28 49 11 2414.8TAC1, TSPO, NGF
36cycloheximide4410.8GAP43, IL11, HBEGF, NGF, PTGS1
37cyclic amp44 2411.8GAP43, NGF, TAC1, IL11, HBEGF
38zopiclone44 1111.7PTGS1, TSPO
39pgj-24410.7PTGS1, NGF
40eszopiclone44 1111.7TSPO, PTGS1
4112-o-tetradecanoylphorbol 13-acetate4410.7GAP43, NGF, HBEGF, IL11
42lte44410.7PTGS1, RNASE3
43uric acid44 2411.7UMOD, RNASE3
44calcium oxalate4410.6UMOD, NAGLU
45polysaccharide4410.6RNASE3, HBEGF, NGF, UMOD
46levodopa44 1111.5NGF, TAC1, TSPO
47vitamin d4410.5NAGLU, IL11, NGF, PTGS1
48ethanol44 49 11 2413.5IL11, RNASE3, GAP43, P2RX3
4911-dehydrothromboxane b24410.4RNASE3, PTGS1
50nedocromil sodium4410.2TAC1, RNASE3

GO Terms for genes affiliated with Cystitis

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16Gene Ontology
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Biological processes related to Cystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1behavioral response to painGO:04826610.5TSPO, P2RX3

Products for genes affiliated with Cystitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet