MCID: CYS018
MIFTS: 54

Cystitis malady

Nephrological diseases category

Summaries for Cystitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 A urinary tract infection (UTI) (also known as acute cystitis or bladder infection) is an infection that... more...

MalaCards: Cystitis is related to chronic cystitis and chronic interstitial cystitis. An important gene associated with Cystitis is HBEGF (heparin-binding EGF-like growth factor). The drugs ciprofloxacin and methenamine and the compounds txb2 and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and bone marrow, and related mouse phenotype integument.

Aliases & Classifications for Cystitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

cystitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:1679
ICD9CM27 595, 595.9
MeSH34 D003556
NCIt39 C26738
ICD1025 N30, N30.9

Related Diseases for Cystitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Cystitis family:

Acute Cystitis Chronic Cystitis

Diseases related to Cystitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1chronic cystitis31.2NGF, PTGS1
2chronic interstitial cystitis31.1TSPO, SPRR2G, NME2, NME1-NME2, P2RX3, HBEGF
3bladder carcinoma30.5HBEGF, KRT20
4adenocarcinoma30.3KRT20, TSPO, TAC1, HBEGF, PTGS1
5pain disorder30.3NGF, TAC1
6arthritis30.0TAC1, PTGS1
7rheumatoid arthritis30.0TSPO, TAC1, PTGS1, IL11, HBEGF, RNASE3
8urinary tract obstruction29.9UMOD, HBEGF, NAGLU
9pneumonia29.9PTGS1, IL11, NAGLU
10asthma29.9RNASE3, HBEGF, TSPO, NGF, TAC1, IL11
11chronic pyelonephritis29.9UMOD, NAGLU
12leukemia29.9IL11, PTGS1, RNASE3, HBEGF, NGF, GAP43
13panic disorder29.9NAGLU, TSPO
14diabetes mellitus29.9TAC1, NAGLU, NGF, UMOD
15bladder transitional cell carcinoma29.9PTGS1, KRT20
16pancreatitis29.7TAC1, IL11
17bronchiolitis29.7RNASE3, IL11
18colorectal cancer29.7KRT20, PTGS1
19breast cancer29.7NGF, NME2, TAC1, HBEGF, KRT20
20acute cystitis10.8
21radiation cystitis10.7
22cystitis cystica10.7
23prostatitis10.5
24pyelitis10.5
25pyelonephritis10.5
26urethritis10.4
27bacteriuria10.3
28pelvic lipomatosis10.3
29urethral syndrome10.3
30glandular cystitis10.3
31lipomatosis10.3
32acute pyelonephritis10.3
33neurogenic bladder10.2
34bladder adenocarcinoma10.2
35eosinophilic cystitis10.2
36proctitis10.2
37acute gonococcal cystitis10.2
38bladder disease10.2
39eosinophilia10.2
40lupus erythematosus10.2
41nephrogenic adenoma10.1
42systemic lupus erythematosus10.1
43neuronitis10.1
44diphtheritic cystitis10.1
45adenoma10.1
46tuberculosis10.1
47vaginitis10.1
48bladder lymphoma10.0
49cervicitis10.0
50urethral obstruction10.0

Graphical network of the top 20 diseases related to Cystitis:



Diseases related to cystitis

Clinical Features for Cystitis

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Drugs & Therapeutics for Cystitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cystitis

Drug clinical trials:

Search ClinicalTrials for Cystitis

Search NIH Clinical Center for Cystitis

Search CenterWatch for Cystitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cystitis

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Anatomical Context for Cystitis

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32MalaCards
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MalaCards organs/tissues related to Cystitis:

32
Kidney, Prostate, Bone marrow, Bone, Spinal cord, Endothelial, Testes, B cells, Skin, Pituitary, Colon, Uterus, Thyroid, Heart, Breast

Animal Models for Cystitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.5P2RX3, TAC1, NAGLU, HBEGF

Publications for Cystitis

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50PubMed
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Articles related to Cystitis:

(show top 50)    (show all 987)
idTitleAuthorsYear
1
Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. (23485788)
2013
2
BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission. (22999487)
2013
3
Interstitial cystitis/bladder pain syndrome: diagnosis and management. (23430074)
2013
4
Nitric oxide metabolites in the lumbosacral spinal cord interstice and cerebrospinal fluid in female rats with acute cyclophosphamide-induced cystitis. An in vivo microdialysis study. (23579750)
2013
5
Unusual case of emphysematous cystitis seen on FDG PET/CT. (23354039)
2013
6
Statistical Validation of the Shorter-Moldwin Food Sensitivity Questionnaire for Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) Patients. (24316093)
2013
7
'Ketamine-induced ulcerative cystitis' is perhaps better labelled 'ketamine-induced uropathy'. (23714219)
2013
8
Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis. (21904840)
2012
9
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? (23030327)
2012
10
Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness. (22503015)
2012
11
Co-morbidities of interstitial cystitis. (22907988)
2012
12
Re: Dean A. Tripp, J. Curtis Nickel, Jennifer Wong, et al. Mapping of pain phenotypes in female patients with bladder pain syndrome/interstitial cystitis and controls. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2012.05.023. (22766169)
2012
13
Empirical treatment of uncomplicated cystitis. (22348511)
2012
14
Group B streptococcus cystitis presenting in a diabetic patient with a massive abdominopelvic abscess: a case report. (22883571)
2012
15
Cyclosporine A for refractory interstitial cystitis/bladder pain syndrome: experience of 3 tertiary centers. (22901569)
2012
16
Diagnosis and treatment of interstitial cystitis in adolescents. (21600805)
2012
17
Virulence determinants, phylogenetic groups and fluoroquinolone resistance in Escherichia coli isolated from cystitis and pyelonephritis. (21872408)
2012
18
The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis. (22511431)
2012
19
Severe emphysematous cystitis: Outcome after seven days of antibiotics. (22363178)
2011
20
Normalization of proliferation and tight junction formation in bladder epithelial cells from patients with interstitial cystitis/painful bladder syndrome by d-proline and d-pipecolic acid derivatives of antiproliferative factor. (21352500)
2011
21
Septic peritonitis and uroperitoneum secondary to subclinical omphalitis and concurrent necrotizing cystitis in a colt. (22294797)
2011
22
Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. (18199362)
2007
23
Chronic cystitis with ossification of the bladder wall in a 6-month-old German shepherd dog. (17966335)
2007
24
Eosinophilic cystitis in a female German wire-haired pointer. (17542370)
2007
25
Eosinophilic cystitis simulating invasive bladder cancer: a real diagnostic challenge. (17115289)
2006
26
Primary splenic marginal zone lymphoma with bladder metastases mimicking interstitial cystitis. (17033884)
2006
27
Eosinophilic cystitis. A rare inflammatory pathology mimicking bladder neoplasms. (14512650)
2003
28
Imaging characteristics of alkaline-encrusted cystitis and pyelitis. (11804900)
2002
29
Eosinophilic cystitis: eight cases report and literature review. (12017980)
2002
30
Over expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in patients with interstitial cystitis and bladder carcinoma. (11743354)
2002
31
Encrusted cystitis and pyelitis. (11306884)
2001
32
Chronic cystitis caused by Corynebacterium urealyticum detected by polymerase chain reaction. (11205634)
2000
33
Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis. (10751853)
2000
34
Urinary bacterial flora of women with urethral syndrome and interstitial cystitis. (9852391)
1999
35
Increased urinary levels of adrenomedullin in patients with cystitis. (10196022)
1999
36
Combined use of urinary alpha1-microglobulin and 99mTc DMSA scintigraphy in the diagnosis and follow-up of acute pyelonephritis and cystitis in children. (9831790)
1998
37
Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. (7674746)
1995
38
Management of severe chronic radiation cystitis. (1416787)
1992
39
Pharmacodynamic evaluation of ofloxacin and trimethoprim-sulfamethoxazole in vaginal fluid of women treated for acute cystitis. (3075434)
1988
40
Persistent tuberculous cystitis: the most common indication for nephrectomy in the management of urogenital tuberculosis. (3582454)
1987
41
Late radiation cystitis after treatment for carcinoma of the bladder. (3787396)
1986
42
A randomised comparison of single-dose vs. three-day and ten-day therapy with trimethoprim-sulfamethoxazole for acute cystitis in women. (6396834)
1984
43
Gas gangrene of the bladder complicating cyclophosphamide cystitis. (6697098)
1984
44
Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis. (7014730)
1981
45
Eosinophilic cystitis. A study of 16 cases. (506991)
1979
46
Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis. (566977)
1978
47
Feline cystitis, urethritis, urethral obstruction syndrome. Part IV: adverse drug reactions; client education. (714008)
1978
48
Hemorrhagic radiation cystitis. Treatment. (4812667)
1974
49
The Genesis and Development of Brunn's Nests and Their Relation to Cystitis Cystica, Cystitis Glandularis, and Primary Adenocarcinoma of the Bladder. (20320089)
1935
50
The Etiology and Pathology of Pyelitis Cystica, Ureteritis Cystica and cystitis cystica. (19969776)
1928

Genetic Variations for Cystitis

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Expression for genes affiliated with Cystitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystitis

Search GEO for disease gene expression data for Cystitis.

Pathways for genes affiliated with Cystitis

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Compounds for genes affiliated with Cystitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Cystitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1txb24410.9PTGS1, NAGLU, RNASE3, IL11
2heparin44 28 11 2413.9NAGLU, IL11, RNASE3, HBEGF, GAP43, UMOD
3h2o24410.9GAP43, NAGLU, TAC1, PTGS1, TSPO, RNASE3
4dbc-amp4410.9NGF, GAP43, NAGLU, RNASE3
5acetylcholine44 49 28 11 2414.9TSPO, GAP43, NGF, TAC1, P2RX3, RNASE3
6theophylline44 28 11 2413.9NGF, RNASE3, TAC1, TSPO
7nitric oxide44 11 2412.9TAC1, PTGS1, GAP43, NAGLU, IL11, P2RX3
8dexamethasone44 49 28 1113.9HBEGF, RNASE3, TAC1, GAP43
9cysteine4410.9PTGS1, UMOD, TAC1, IL11, GAP43, NGF
10hyaluronic acid44 2411.9KRT20, PTGS1, IL11, NAGLU, RNASE3
11capsaicin44 2811.9P2RX3, TAC1, RNASE3, NGF
12valproic acid44 49 11 2413.9GAP43, NAGLU, TSPO, PTGS1
13phorbol4410.9NME2, HBEGF, GAP43, RNASE3
14nmda44 2811.9GAP43, NGF, TAC1, PTGS1, TSPO
15indomethacin44 59 28 1113.9NGF, TSPO, TAC1, PTGS1, IL11
16dopamine44 28 11 2413.9NAGLU, NGF, GAP43, TAC1, IL11, TSPO
17estrogen4410.9TAC1, RNASE3
18calcium44 49 11 2413.9UMOD, P2RX3, TAC1, IL11, RNASE3, NAGLU
19budesonide44 49 1112.9PTGS1, RNASE3, IL11
20histamine44 28 2412.9TSPO, NGF, TAC1, IL11, RNASE3
21ifosfamide44 1111.9IL11, PTGS1, NAGLU
22carbachol44 28 1112.9TAC1, NGF, GAP43, IL11
23cyclosporin a44 28 5912.8RNASE3, NGF, IL11, TSPO, NAGLU
24vegf4410.8RNASE3, HBEGF, NGF, PTGS1, IL11, KRT20
256-hydroxydopamine4410.8TAC1, GAP43, NGF
26steroid4410.8TSPO, TAC1, GAP43, IL11, RNASE3, NAGLU
27mptp4410.8NGF, TAC1, TSPO
28glutamate4410.8TSPO, PTGS1, TAC1, HBEGF, NGF, GAP43
29alanine4410.8GAP43, IL11, HBEGF, PTGS1, NGF, NAGLU
30creatinine4410.8NGF, NAGLU, RNASE3, TSPO, UMOD
31resiniferatoxin44 2811.8TAC1, P2RX3
32tyrosine4410.8KRT20, GAP43, IL11, NME2, TAC1, NGF
33aspartate4410.8GAP43, PTGS1, NAGLU, TAC1, IL11
34epinephrine44 11 2412.8NGF, TAC1, IL11, RNASE3
35propranolol44 28 49 11 2414.8TAC1, TSPO, NGF
36cycloheximide4410.8GAP43, IL11, HBEGF, NGF, PTGS1
37cyclic amp44 2411.8GAP43, NGF, TAC1, IL11, HBEGF
38zopiclone44 1111.7PTGS1, TSPO
39pgj-24410.7PTGS1, NGF
40eszopiclone44 1111.7TSPO, PTGS1
4112-o-tetradecanoylphorbol 13-acetate4410.7GAP43, NGF, HBEGF, IL11
42lte44410.7PTGS1, RNASE3
43uric acid44 2411.7UMOD, RNASE3
44calcium oxalate4410.6UMOD, NAGLU
45polysaccharide4410.6RNASE3, HBEGF, NGF, UMOD
46levodopa44 1111.5NGF, TAC1, TSPO
47vitamin d4410.5NAGLU, IL11, NGF, PTGS1
48ethanol44 49 11 2413.5IL11, RNASE3, GAP43, P2RX3
4911-dehydrothromboxane b24410.4RNASE3, PTGS1
50nedocromil sodium4410.2TAC1, RNASE3

GO Terms for genes affiliated with Cystitis

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16Gene Ontology
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Biological processes related to Cystitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1behavioral response to painGO:04826610.5TSPO, P2RX3

Products for genes affiliated with Cystitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet