Cystitis malady

Wikipedia: Cystitis is a urinary bladder inflammation that can result from any one of a number of distinct...⁴⁴ more...

MalaCards: Cystitis is related to interstitial cystitis and chronic interstitial cystitis. An important gene associated with Cystitis is LEPREL4 (leprecan-like 4), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and IL-6 Pathway. The drugs amphotericin b and carboprost and the compounds glucose and carbachol have been mentioned in the context of this disorder. Affiliated tissues include kidney, nk cells and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions:

cystitis 6 8 32 43

Diseases related to cystitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 874)

id	Related Disease	Score	Top Affiliating Genes
1	interstitial cystitis	37.1	NCAM2, ZDHHC2, CKAP4, LEPREL4, P2RX3, FZD8
2	chronic interstitial cystitis	33.3	NCAM2, ZDHHC2, CKAP4, LEPREL4, P2RX3, FZD8
3	chronic cystitis	32.1	KIT, RBM6, PTGS1, NGF
4	paine syndrome	29.9	CHI3L1, IL1A, IL6, IL8, CAV1, TNF
5	bladder disease	29.8	TRPV1, PPIG, HBEGF
6	bacteriuria	27.9	PCDH8, SERPINA2, UMOD, IL6, IL8, IGKV1-33
7	bladder carcinoma	23.3	PCNA, RBM6, VEGFA, BMP6, UPK3A, CKAP4
8	colorectal cancer	15.0	KIT, KITLG, PCDH8, PCNA, VEGFA, BMP6
9	hypoxia	14.9	KIT, KITLG, PCNA, VEGFA, BMP6, PARP1
10	carcinoma	14.1	KIT, KITLG, PCNA, RBM6, NAGLU, VEGFA
11	paraurethral gland neoplasm	14.0	CDX2, KRT7, KRT20
12	bladder adenocarcinoma	14.0	CDX2, KRT7, KRT20
13	signet ring cell adenocarcinoma	14.0	CDX2, KRT7, KRT20
14	ovarian brenner tumor	13.9	UPK3A, KRT7, KRT20
15	chronic pain	13.9	P2RX3, IL6, PTGS1, NGF, PDYN, TACR1
16	urinary tract obstruction	13.9	NAGLU, UMOD, HBEGF
17	pancreatic mucinous cystadenoma	13.9	KIT, MUC5AC, KRT20
18	urinary system disease	13.9	NAGLU, UMOD, LACTB, KRT20
19	mucinous ovarian cystadenoma	13.9	MUC2, KRT7, KRT20, PSG2
20	pancreatic ductal carcinoma	13.9	MUC2, MUC5AC, KRT7, KRT20
21	memory impairment	13.9	ITIH4, NGF, PDYN, TSPO, GAP43
22	chronic eosinophilic pneumonia	13.9	RNASE3, CXCL9, CXCR3
23	signet ring basal cell carcinoma	13.8	MUC2, CDH1, KRT7, KRT20
24	low compliance bladder	13.8	P2RX3, NGF, ADRB3
25	radiculopathy	13.8	IL1A, IL6, CXCL9, CXCR3, KNG1
26	perinatal necrotizing enterocolitis	13.8	LACTB, EGF, HBEGF
27	bronchiolo-alveolar adenocarcinoma	13.8	MUC2, MUC5AC, CDX2, CDH1, KRT7, KRT20
28	ampulla of vater adenocarcinoma	13.7	MUC1, MUC2, MUC5AC, CDX2, KRT7, KRT20
29	gastrointestinal system disease	13.7	TRPV1, CRH, HBEGF, TACR1, PSG2
30	microinvasive gastric cancer	13.7	MUC2, CDX2, CDH1, PSG2
31	contact dermatitis	13.7	IL1A, CXCL9, CXCR3
32	small intestine adenocarcinoma	13.7	MUC1, MUC2, MUC5AC, CDX2
33	adenosquamous carcinoma	13.7	MUC1, MUC2, MUC5AC, KRT7, KRT20
34	papillary serous adenocarcinoma	13.7	ERBB2, KRT7, KRT20
35	mucinous cystadenocarcinoma	13.7	MUC1, KRT7, KRT20
36	merkel cell carcinoma	13.7	KIT, MUC1, ENO2, KRT20
37	neuroendocrine tumor	13.7	CDX2, ENO2, KRT20, TAC1, PSG2, NPY
38	sleep apnea	13.7	TSPO, NPY, KNG1, ADRB2
39	pseudomyxoma peritonei	13.7	MUC2, MUC5AC, CDX2, CDH1, KRT7, KRT20
40	oxyphilic adenoma	13.7	KIT, MUC1, CAV1, KRT7, KRT20
41	angioedema	13.7	IL6, HRH1, PTGS1, RNASE3, KNG1
42	multiple sclerosis	13.7	UBD, IL11, IL1A, IL4R, PTPRCAP, PTPRC
43	biliary papillomatosis	13.7	MUC1, MUC2, MUC5AC
44	dry eye syndrome	13.7	MUC1, MUC5AC, CD44, IL6, NGF
45	appendicitis	13.6	LACTB, CRP, GAP43
46	hairy cell leukemia	13.6	IL1A, HMMR, PTPRC, CXCR3
47	melioidosis	13.6	IL6, CRP, CXCL9, CXCR3
48	acute megakaryoblastic leukemia	13.6	KIT, RBM6, BMP6, IL6
49	mammary paget's disease	13.6	MUC1, ERBB2, KRT7, KRT20
50	viral meningitis	13.6	IL6, CRP, CXCR3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amphotericin b, amphotericin b cholesteryl sulfate, amphotericin b lipid complex, amphotericin b liposome, carboprost, ciprofloxacin, ciprofloxacin hydrochloride, gatifloxacin, methenamine, methenamine hippurate, methenamine mandelate, methenamine sulfosalicylate, moxifloxacin, moxifloxacin hcl, norfloxacin, ofloxacin

MalaCards organs/tissues related to cystitis:

²²

MGI Mouse Phenotypes related to cystitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	ADRB3, CAV1, CDX2
2	respiratory system phenotype	MP:0005388	10.0	TH, NOS1, CRH, PTPRC, CASK, P2RX3
3	hematopoietic system phenotype	MP:0005397	9.9	PTPRC, PTPRCAP, TNFSF14, CCL7, MAPK9, IL4R
4	renal/urinary system phenotype	MP:0005367	9.8	PTGS1, PTPRC, HIF1A, TAC1, DCN, ADM
5	liver/biliary system phenotype	MP:0005370	8.3	TP53, PTPRC, HIF1A, TH, ADM, TRPV1
6	no phenotypic analysis	MP:0003012	7.8	TP53, TRPV1, CDH1, CD44, MUC1, PARP1
7	behavior/neurological phenotype	MP:0005386	7.5	TH, HBEGF, PDYN, NGF, NOS2, TACR1
8	reproductive system phenotype	MP:0005389	7.4	CAV1, ERBB2, TNF, PTGS1, NOS2, IL6
9	immune system phenotype	MP:0005387	7.3	NAGLU, KIT, TERT, TNF, TP53, TRPV1
10	adipose tissue phenotype	MP:0005375	7.2	TNF, NOS1, NOS2, PDYN, NPY, ADRB2
11	digestive/alimentary phenotype	MP:0005381	7.1	TERT, PTGS1, PTPRC, NOS1, NOS2, PDYN
12	integument phenotype	MP:0010771	7.0	ATF2, P2RX3, MUC1, PARP1, KITLG, KIT
13	mortality/aging	MP:0010768	6.7	NGF, NOS2, NOS1, TP53, CAV1, NFKBIA
14	skeleton phenotype	MP:0005390	5.6	CAV1, ERBB2, TP53, TERT, PTPRC, NOS1
15	vision/eye phenotype	MP:0005391	5.6	TP53, TNF, NOS1, NOS2, NGF, EGF
16	muscle phenotype	MP:0005369	5.5	PTGS1, NOS1, NOS2, HBEGF, HIF1A, DCN
17	tumorigenesis	MP:0002006	5.4	CST3, IGF1, MAPK9, MAPK14, IL6, IL1A
18	growth/size phenotype	MP:0005378	5.1	GAP43, ADRB3, ADRB2, NPY, HRH1, CASK
19	cardiovascular system phenotype	MP:0005385	4.5	NOS2, NOS1, CRP, PTGS1, TNF, TP53
20	cellular phenotype	MP:0005384	2.7	NOS1, CRH, PTPRC, PTPRCAP, PTGS1, TERT
21	homeostasis/metabolism phenotype	MP:0005376	1.7	NFKBIA, NOS2, NOS1, CRP, CRH, PTPRC
22	normal phenotype	MP:0002873	INF	PTPRCAP, PTPRC, CRH, NOS1, NFKBIA, HBEGF
23	nervous system phenotype	MP:0003631	INF	HBEGF, PDYN, NGF, NOS1, CRH, HIF1A

Articles related to cystitis:

(show top 50)    (show all 80)

id	Title	Authors	Year	Affiliating Genes
1	Endogenous nerve growth factor regulates collagen exp ression and bladder hypertrophy through Akt and MAPK pathways during cystitis. (19996110)	Chung C.W.... Qiao L.Y.	2010	NGF
2	CXCR3 binding chemokine and TNFSF14 over expression i n bladder urothelium of patients with ulcerative interstitial cystitis. (20096889)	Ogawa T.... Nishizawa O.	2010	CXCR3, TNFSF14
3	Increased nerve growth factor in neurogenic overactiv e bladder and interstitial cystitis patients. (20156378)	Jacobs B.L.... Tyagi P.	2010	NGF
4	Antimicrobial resistance among uropathogens that caus e acute uncomplicated cystitis in women in Hong Kong: a prospective multicenter study in 2006 to 2008. (19446980)	Ho P.L.... Yuen K.Y.	2010	LACTB
5	YKL-40 and mast cells are associated with detrusor fi brosis in patients diagnosed with bladder pain syndrome/interstitial cystitis a ccording to the 2008 criteria of the European Society for the Study of Intersti tial Cystitis. (20840668)	Richter B.... Hansen A.B.	2010	CHI3L1
6	Urinary nerve growth factor level is increased in pat ients with interstitial cystitis/bladder pain syndrome and decreased in respond ers to treatment. (19522864)	Liu H.T.... Kuo H.C.	2009	NGF
7	Aminoguanidine, selective nitric oxide synthase inhib itor, ameliorates cyclophosphamide-induced hemorrhagic cystitis by inhibiting p rotein nitration and PARS activation. (19251306)	Abraham P.... Kulothungan P.	2009	EPRS
8	Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. (18990151)	Kim J.... Freeman M.R.	2009	MAPK14, HBEGF
9	Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation. (19303104)	Kiuchi H.... Okuyama A.	2009	TNF, NFKBIA
10	Abnormal glycosylation of Tamm-Horsfall protein in patients with interstitial cystitis. (19007360)	Argade S.P.... Parsons C.L.	2009	UMOD
11	Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. (19909543)	Rudick C.N.... Klumpp D.J.	2009	TACR1
12	Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis. (18554637)	Koskela L.R.... Wiklund N.P.	2008	NOS2
13	Genotypic characterization of virulence factors in Es cherichia coli strains from patients with cystitis. (18949339)	Tiba M.R.... Leite D.d.a. .S.	2008	CDB2
14	Loss of prostaglandin E2 release from immortalized urothelial cells obtained from interstitial cystitis patient bladders. (18322019)	Rastogi P.... McHowat J.	2008	PLA2G2A
15	CXCL10 blockade protects mice from cyclophosphamide-induced cystitis. (18957084)	Sakthivel S.K.... Lillard J.W.	2008	CXCR3, CXCL9
16	Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. (18082196)	Hauser P.J.... Hurst R.E.	2008	DCN
17	Urinary epidermal growth factor and interleukin-6 lev els in patients with painful bladder syndrome/interstitial cystitis treated wit h cyclosporine or pentosan polysulfate sodium. (18387391)	Sairanen J.... Ruutu M.	2008	IL6
18	Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects. (18455532)	Canter M.P.... Merchant M.L.	2008	KNG1, UMOD, ITIH4
19	Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. (18199362)	Raj A.... Bertolone S.J.	2007	IL11
20	EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients. (16837648)	Sun Y.... Chai T.C.	2007	EGF, HBEGF
21	Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. (18199361)	Gorczynska E.	2007	IL11
22	Neural upregulation in interstitial cystitis. (17462476)	Nazif O.... Gebhart G.F.	2007	PDYN, P2RX3
23	Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. (17980069)	Mota J.M.... Ribeiro R.d.e. .A.	2007	IL11
24	p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. (17628545)	Kim J.... Freeman M.R.	2007	TP53
25	Differences in the expression of mucins in various forms of cystitis glandularis. (17659847)	Jankovic Velickovic L.... Stefanovic V.	2007	MUC1, MUC2, MUC5AC
26	Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder. (16951671)	Sung M.T.... Cheng L.	2006	KRT7, CDX2, KRT20
27	Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis. (16971769)	Nishijima S.... Ogawa Y.	2006	ADRB2
28	Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. (16107499)	Sun Y.... Chai T.C.	2006	HBEGF
29	Interleukin-6, histamine, and methylhistamine as diag nostic markers for interstitial cystitis. (17070335)	Lamale L.M.... Kreder K.J.	2006	IL6
30	APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis. (15862132)	Zhang C.O.... Kong C.Z.	2005	EGF, HBEGF
31	Systemic aspects of interstitial cystitis, immunology and linkage with autoimmune disorders. (14641413)	van de Merwe J.P.... Sakamoto Y.	2003	CD44
32	Serum amyloid A: a novel serum marker for the detection of systemic inflammatory response in cystitis. (12913703)	Lannergard A.... Larsson A.	2003	CRP
33	Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (12442007)	Sugaya K.... Ogawa Y.	2002	ADRB2, IL4, ADRA1D
34	Isolation and immunochemical characterization of human cystitis C. (16212561)	BegiA8 L.... BerbiA8 S.	2002	CST3
35	Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis. (11378043)	Keay S.K.... Chai T.	2001	EGF, HBEGF
36	Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis. (10702392)	Saban R.... Hammond T.G.	2000	TACR1, TAC1
37	Increased tyrosine hydroxylase immunoreactivity in bladder tissue from patients with classic and nonulcer interstitial cystitis. (10737477)	Peeker R.... Fall M.	2000	ENO2, NPY
38	Percutaneous sacral third nerve root neurostimulation improves symptoms and normalizes urinary HB-EGF levels and antiproliferative activity in patients with interstitial cystitis. (10792070)	Chai T.C.... Keay S.	2000	HBEGF
39	Cyto-injury factors in urine: a possible mechanism fo r the development of interstitial cystitis. (10992419)	Parsons C.L.... Zupkas P.	2000	UMOD
40	Urothelial cytoprotective activity of Tamm-Horsfall protein isolated from the urine of healthy subjects and patients with interstitial cystitis. (10830825)	Akiyama A.... Parsons C.L.	2000	UMOD
41	Activation of the kallikrein kinin system in intersti tial cystitis. (10379755)	Rosamilia A.... Campbell D.J.	1999	KNG1
42	Increased urinary levels of adrenomedullin in patients with cystitis. (10196022)	Nishitani Y.... Dohi K.	1999	ADM
43	Increased tyrosine hydroxylase immunoreactivity in th e locus coeruleus of cats with interstitial cystitis. (9474229)	Reche JA_nior A.... Buffington C.A.	1998	TH
44	Post radiation hemorrhagic cystitis: MR findings. (9364959)	Worawattanakul S.... Kelekis N.L.	1997	HBG2
45	Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. (9126085)	Lowe E.M.... Osborne J.L.	1997	NGF
46	Concentrations of specific epithelial growth factors in the urine of interstitial cystitis patients and controls. (9334654)	Keay S.... Warren J.W.	1997	EGF, IGF1, IGFBP3
47	Xanthogranulomatous cystitis as a cause of elevated carcinoembryonic antigen mimicking recurrent colorectal cancer. Report of a case. (8797658)	Garcia A.A.... Leichman L.W.	1996	PSG2
48	p53 and c-erbB-2 expression in schistosomal urinary bladder carcinomas and schistosomal cystitis with premalignant lesions. (7911381)	Kamel D.... PAoAokkAP P.	1994	ERBB2, TP53
49	In vitro passive sensitization of guinea pig, rhesus monkey and human bladders as a model of noninfectious cystitis. (7523714)	Bjorling D.E.... Saban R.	1994	HRH1
50	Evidence for urothelial cell activation in interstitial cystitis. (8094760)	Liebert M.... Grossman H.B.	1993	IL1A

Genes related to cystitis according to GeneCards:

(show top 50)    (show all 100)

id	Symbol	Description	Score	GeneCards Section Context
1	LEPREL4	leprecan-like 4	11.1	Summaries
2	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
3	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
4	CKAP4	cytoskeleton-associated protein 4	11.0	Publications
5	FZD8	frizzled family receptor 8	11.0
6	P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	11.0	Publications
7	ZDHHC2	zinc finger, DHHC-type containing 2	11.0
8	TSPO	translocator protein (18kDa)	11.0
9	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0
10	UMOD	uromodulin	11.0	Publications
11	IL11	interleukin 11	11.0	Publications
12	GAP43	growth associated protein 43	11.0	Publications
13	RBM6	RNA binding motif protein 6	11.0
14	TAC1	tachykinin, precursor 1	11.0	Publications
15	KRT7	keratin 7	11.0	Publications
16	CDX2	caudal type homeobox 2	11.0	Publications
17	KRT20	keratin 20	11.0	Publications
18	TACR1	tachykinin receptor 1	11.0	Publications
19	NAGLU	N-acetylglucosaminidase, alpha	11.0
20	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
21	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
22	IL1A	interleukin 1, alpha	11.0	Publications
23	EGF	epidermal growth factor	11.0	Publications
24	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
25	IGKV1-33	immunoglobulin kappa variable 1-33	11.0
26	IGKV1-37	immunoglobulin kappa variable 1-37 (non-functional)	11.0
27	CDB2	corneal dystrophy of Bowman layer type II (Thiel-Behnke)	11.0	Publications
28	UPK2	uroplakin 2	11.0
29	UPK3A	uroplakin 3A	11.0	Publications
30	UPK1A	uroplakin 1A	11.0	Publications
31	BNC1	basonuclin 1	11.0	Publications
32	PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein	11.0
33	FIBP	fibroblast growth factor (acidic) intracellular binding protein	11.0	Publications
34	HAS1	hyaluronan synthase 1	11.0	Publications
35	PCDH8	protocadherin 8	11.0
36	SERPINA2	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2	11.0
37	CGN	cingulin	11.0	Publications
38	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
39	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	11.0	Publications
40	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	11.0
41	UBD	ubiquitin D	11.0
42	ADRA1D	adrenoceptor alpha 1D	11.0	Publications
43	HMMR	hyaluronan-mediated motility receptor (RHAMM)	11.0	Publications
44	PDYN	prodynorphin	11.0	Publications
45	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
46	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
47	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
48	CCL7	chemokine (C-C motif) ligand 7	11.0
49	ADM	adrenomedullin	11.0	Publications
50	TJP1	tight junction protein 1	11.0	Publications

Pathways related to cystitis according to GeneDecks:

(show top 50)    (show all 156)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.2	CCL7, MAPK9, MAPK14, IL11, TNFSF14, CXCL9
2	IL-6 Pathway36	9.8	TNFSF14, CXCL9, CCL7, IL8, IL4, BMP6
3	Akt Signaling36	9.7	IL11, CXCR3, CXCL9, TNF, CCL7, IL6
4	Hematopoietic cell lineage20	9.6	TNF, IL6, IL4R, IL4, IL1A, IL11
5	Calcium signaling pathway20	9.6	TACR1, P2RX2, HRH1, ADRB3, NOS1, NOS2
6	Development Ligand-independent activation of ESR1 and ESR210	9.5	ADRB2, HRH1, ERBB2, EGF, ADRB3
7	Endothelin-1 Signaling Pathway36	9.4	IL4, IL6, MAPK9, CCL7, ERBB2, TNFSF14
8	ERK Signaling36	9.4	CCL7, TNFSF14, ERBB2, IL6, NFKBIA, CXCL9
9	all-trans-Retinoic Acid Signaling in Brain36	9.2	CCL7, PLA2G2A, CXCL9, IL8, TNFSF14, TNF
10	PGC1Alpha Pathway36	9.2	CCL7, IL8, IL4R, IL4, IL1A, IL11
11	NF-KappaB Activation by EBV36	9.1	JUN, FOS, MAPK14, NFKBIA, EGF, MAPK9
12	MIF Mediated Glucocorticoid Regulation36	9.1	IL1A, IL4, PLA2G2A, NFKBIA, CXCL9, TNFSF14
13	Mucin expression in CF via TLRs, EGFR signaling pathways41	9.0	ATF2, FOS, IL6, MAPK14, MAPK9, JUN
14	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.9	IGF1, IL6, IL1A, FOS, CDX2, JUN
15	p70S6K Signaling36	8.9	IGF1, MAPK9, MAPK14, IL4R, IL4, BMP6
16	PI3K Signaling in B-Lymphocyte36	8.8	ATF2, NFKBIA, MAPK9, JUN, FOS, IL4R
17	STAT3 Pathway36	8.7	BMP6, IL11, IL1A, IL4, IL4R, CXCR3
18	PAK Pathway36	8.7	TNFSF14, IL8, BMP6, IL6, IL4, IL1A
19	PEDF Induced Signaling36	8.7	CCL7, IL8, IL6, IL4, IL1A, IL11
20	EGF Pathway36	8.7	MUC1, EGF, ERBB2, CAV1, MAPK9, FOS
21	JNK Pathway36	8.7	BMP6, JUN, KITLG, EGF, CCL7, MAPK9
22	Cytokine-cytokine receptor interaction20	8.5	KIT, KITLG, VEGFA, IL11, IL1A, CXCR3
23	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.5	IL1A, IL6, IGF1, TNF, CDX2, JUN
24	Immune response MIF-mediated glucocorticoid regulation10	8.5	FOS, IL8, TNF, NOS2, NFKBIA, IL6
25	Immune response_MIF-mediated glucocorticoid regulation41	8.5	JUN, TNF, FOS, IL6, IL8, NOS2
26	14-3-3 Induced Intracellular Signaling36	8.5	TNF, IGF1, MAPK9, MAPK14, KITLG, ERBB2
27	TRAF Pathway36	8.4	UBD, FOS, NFKBIA, TNF, MAPK9, MAPK14
28	ILK Signaling36	8.4	CDH1, EGF, ERBB2, IGF1, MAPK9, FOS
29	Toll-like receptor signaling pathway20	8.3	NFKBIA, FOS, JUN, TNF, MAPK9, MAPK14
30	Glucocorticoid Receptor Signaling36	8.3	IL6, NFKBIA, CCL7, MAPK9, JUN, IL4R
31	Pertussis20	8.3	IL6, IL8, MAPK14, MAPK9, TNF, NOS2
32	Leishmaniasis20	8.2	MAPK14, TNF, NOS2, NFKBIA, FOS, IL4
33	PKR Pathway36	8.1	MAPK9, TP53, NFKBIA, MAPK14, FOS, ATF2
34	Immune response IL-1 signaling pathway10	8.1	NFKBIA, MAPK9, TNF, NOS2, MAPK14, IL8
35	Immune response_IL-1 signaling pathway41	8.1	NFKBIA, MAPK9, NOS2, TNF, MAPK14, IL8
36	NFAT in Immune Response36	8.1	EGF, ERBB2, IGF1, MAPK9, KIT, JUN
37	Chagas disease (American trypanosomiasis)20	8.0	JUN, FOS, MAPK14, MAPK9, TNF, NOS2
38	JAK-STAT Pathway36	8.0	IL11, FOS, JUN, UBD, BMP6, EGF
39	Molecular Mechanisms of Cancer36	7.9	CDH1, JUN, FZD8, BMP6, KITLG, FOS
40	Tec Kinases Signaling36	7.9	MAPK9, EGF, TNF, ERBB2, IGF1, CCL7
41	Rho Family GTPases36	7.8	TNFSF14, KIT, IL1A, ERBB2, BMP6, IL8
42	Immune response_MIF in innate immunity response41	7.8	TP53, TNF, NFKBIA, MAPK9, MAPK14, IL8
43	Immune response MIF in innate immunity response10	7.8	NOS2, TNF, IL6, MAPK9, MAPK14, IL8
44	TGF-Beta Pathway36	7.7	IL8, IL11, EGF, IGF1, CCL7, KITLG
45	MAPK Family Pathway36	7.7	MAPK14, KITLG, BMP6, ATF2, JUN, IL11
46	Antioxidant Action of Vitamin-C36	7.3	KIT, KITLG, BMP6, ATF2, JUN, FOS
47	MIF Regulation of Innate Immune Cells36	7.2	IL6, IL4, IL1A, IL8, MAPK9, CCL7
48	Pathways in cancer20	7.2	HIF1A, FOS, CDH1, MAPK9, ERBB2, TP53
49	p38 Signaling36	7.1	IL6, IL4, CXCL9, CXCR3, EGF, TNFSF14
50	MAPK Signaling36	6.8	TP53, TNF, EGF, KIT, ERBB2, IGF1

Compounds related to cystitis according to GeneDecks:

(show top 50)    (show all 398)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	KIT, SERPINA2, UMOD, ATF2, IL11, TJP1
2	carbachol32 9 9	12.3	IL11, HRH1, CRH, TAC1, KNG1, ADRB2
3	egcg32	10.0	ITIH4, IL1A, MAPK14, IGFBP3, PTGS1, NFKBIA
4	sodium nitroprusside32	9.3	PCNA, BMP6, PTGS1, CRH, NFKBIA, HBG2
5	epinephrine32 9 18 9	12.3	KITLG, BMP6, IL11, IL1A, IGFBP3, HRH1
6	h2o232	9.2	KITLG, NAGLU, ATF2, ITIH4, MAPK14, MAPK9
7	heparin32 9 18 9	11.9	KITLG, UMOD, CDH1, ITIH4, IL11, ENO2
8	aspartate32	8.9	PCNA, NAGLU, BMP6, CDH1, ITIH4, IL11
9	dopamine32 9 18 9	11.9	NAGLU, BMP6, ITIH4, FOS, IL11, HRH1
10	nmda32 42	9.9	ITIH4, FOS, IL1A, ENO2, HRH1, TRPV1
11	capsaicin32	8.7	P2RX3, FOS, HRH1, TRPV1, CRH, NOS1
12	prostaglandin32	8.6	KITLG, MUC5AC, IL11, IL1A, IL6, ENO2
13	calcitriol32 42 9 18 9	12.6	KITLG, BMP6, ATF2, JUN, CD44, CDH1
14	mg 13232 42	9.3	PCNA, PARP1, JUN, CDH1, IL1A, IL8
15	norepinephrine32 9 18 9	11.3	KITLG, BMP6, IL1A, IL6, ENO2, IGFBP3
16	ribonucleic acid32	8.3	KIT, KITLG, BMP6, MUC1, MUC5AC, FOS
17	arginine32	8.2	CD44, ITIH4, IL1A, CAV1, ERBB2, TERT
18	glutamate32	8.0	PCNA, BMP6, CDH1, ITIH4, FOS, MAPK9
19	acetylcholine32 9 18 9	11.0	BMP6, P2RX3, IL1A, ENO2, CAV1, ERBB2
20	forskolin32 42 9 9	10.8	BMP6, MUC1, MUC2, ATF2, JUN, FOS
21	formaldehyde32 18	8.8	KIT, PCNA, MUC1, CD44, CDH1, IL1A
22	testosterone32 9 18 9	10.8	KIT, KITLG, PCNA, SERPINA2, MUC1, MUC5AC
23	histamine32 18	8.8	KIT, KITLG, PCNA, BMP6, MUC5AC, CDH1
24	estrogen32	7.8	PCNA, CHI3L1, MUC2, MUC5AC, CDX2, CDH1
25	cyclosporin a32 42	8.8	KITLG, NAGLU, JUN, CD44, ITIH4, IL11
26	n acetylcysteine32	7.7	PCNA, NAGLU, MUC5AC, CDH1, FOS, ERBB2
27	hydrocortisone32 9 9	9.6	KITLG, BMP6, MUC1, IL1A, IL4, IL6
28	matrigel32	7.6	VEGFA, BMP6, MUC1, JUN, CD44, CDH1
29	cysteine32	7.6	PCNA, NAGLU, PARP1, UMOD, MUC1, MUC2
30	rantes32	7.4	KITLG, BMP6, JUN, CD44, ITIH4, IL11
31	oxygen32 18	8.4	KITLG, NAGLU, PARP1, MUC5AC, P2RX2, ATF2
32	calcium32 9 18 9	10.3	KIT, KITLG, NAGLU, UMOD, MUC1, MUC2
33	alanine32	7.3	KITLG, PCNA, NAGLU, BMP6, ATF2, CDH1
34	5fluorouracil32	7.2	KIT, KITLG, PCNA, VEGFA, MUC1, MUC2
35	adenylate32	7.1	KITLG, CD44, CDH1, ITIH4, FOS, IL4
36	indomethacin32 9 9	9.0	PCNA, BMP6, CDH1, ITIH4, IL11, IL1A
37	sb 20358032 42	7.9	VEGFA, BMP6, PARP1, CDH1, FOS, IL6
38	herbimycin a32 42	7.7	KITLG, BMP6, JUN, CDH1, FOS, IL11
39	triptolide32	6.6	VEGFA, PARP1, JUN, IL6, IL8, MAPK14
40	doxorubicin32 34 9 9	9.6	KIT, KITLG, VEGFA, BMP6, PARP1, ATF2
41	lactate32	6.5	KIT, KITLG, PCNA, NAGLU, BMP6, CD44
42	paclitaxel32 34 9 9	9.5	KIT, KITLG, PCNA, VEGFA, BMP6, PARP1
43	pdtc32	6.3	PARP1, JUN, FOS, IL1A, IL4, IL6
44	retinoic acid32 42 18	8.2	KIT, KITLG, BMP6, PARP1, ATF2, JUN
45	cisplatin32 34 9 9	8.9	KITLG, PCNA, NAGLU, VEGFA, BMP6, PARP1
46	ly29400232	5.8	VEGFA, MUC2, JUN, CD44, CDH1, FOS
47	butyrate32	5.7	KITLG, PCNA, BMP6, MUC1, MUC2, ATF2
48	genistein32 9 18 9	7.8	KITLG, PCNA, VEGFA, PARP1, JUN, CDH1
49	actinomycin d32	4.3	KIT, KITLG, VEGFA, PARP1, MUC1, MUC2
50	dexamethasone32 42 34 9 9	6.5	KITLG, PCNA, VEGFA, BMP6, PARP1, MUC1

Cellular components related to cystitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	EGF, PDYN, NFKBIA, PTPRC, PTPRCAP, PTGS1
2	basolateral plasma membrane	GO:016323	9.4	SLC16A10, TJP1, ERBB2, CAV1, CASK, CD44
3	external side of plasma membrane	GO:009897	9.3	CXCL9, PTPRC, TNF, IL4, CD44, KIT
4	integral to plasma membrane	GO:005887	8.6	PTPRC, HBEGF, TACR1, CXCR3, ADRB2, ADRA1D
5	cell surface	GO:009986	8.5	TACR1, HBEGF, TNF, HMMR, CAV1, IL1A
6	extracellular region	GO:005576	7.0	HBEGF, EGF, PDYN, RNASE3, NGF, TAC1
7	extracellular space	GO:005615	6.5	ADM, CRH, CRP, PLA2G2A, NGF, EGF

Biological processes related to cystitis according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	behavioral response to pain	GO:048266	10.8	TACR1, TSPO, P2RX3, P2RX2
2	positive regulation of vasoconstriction	GO:045907	10.4	CAV1, HRH1, PTGS1, TACR1
3	hyaluronan metabolic process	GO:030212	10.4	HAS1, HMMR, ITIH4, CD44
4	response to cold	GO:009409	10.3	P2RX3, ADRB2, ADM, ADRB3
5	positive regulation of MAPK cascade	GO:043410	10.1	ADRB3, ADRB2, PTPRC, IGF1, IGFBP3, IL6
6	wound healing	GO:042060	10.0	ADRB2, DCN, ERBB2, IL1A, BNC1
7	aging	GO:007568	9.9	ADRB3, ADM, DCN, TSPO, PTGS1, JUN
8	positive regulation of epithelial cell proliferation	GO:050679	9.8	TACR1, ERBB2, IGF1, BMP6, BNC1
9	response to lipopolysaccharide	GO:032496	9.8	JUN, IL1A, NGF, TAC1, DCN, ADM
10	negative regulation of nitric oxide biosynthetic process	GO:045019	9.8	TSPO, CAV1, IL4
11	negative regulation of lipid storage	GO:010888	9.7	NFKBIA, CRP, TNF, IL6
12	positive regulation of mitosis	GO:045840	9.6	EGF, TNF, IGF1, IL1A
13	positive regulation of cell proliferation	GO:008284	9.6	ADM, ADRA1D, ADRB2, EGF, NGF, IGF1
14	response to mechanical stimulus	GO:009612	9.6	DCN, NGF, TNF, CAV1, JUN, CHI3L1
15	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.4	TNF, CAV1, IL6, IL11, CD44, VEGFA
16	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.4	MAPK9, MAPK14, FOS, JUN, ATF2
17	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	HIF1A, HBEGF, TNF, IGF1, IL6, JUN
18	response to gamma radiation	GO:010332	9.3	IL1A, CAV1, TP53, PTPRC
19	MyD88-independent toll-like receptor signaling pathway	GO:002756	9.2	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
20	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.2	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
21	toll-like receptor 1 signaling pathway	GO:034130	9.2	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
22	toll-like receptor 3 signaling pathway	GO:034138	9.2	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
23	toll-like receptor 2 signaling pathway	GO:034134	9.2	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
24	toll-like receptor signaling pathway	GO:002224	9.1	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
25	stress-activated MAPK cascade	GO:051403	9.1	MAPK9, MAPK14, FOS, JUN, ATF2
26	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.1	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
27	Toll signaling pathway	GO:008063	9.1	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
28	toll-like receptor 4 signaling pathway	GO:034142	9.1	NFKBIA, MAPK9, MAPK14, FOS, JUN, ATF2
29	positive regulation of MAP kinase activity	GO:043406	9.1	EGF, TNF, ERBB2, VEGFA, KITLG
30	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.8	TP53, IGF1, IL6, IL11, CD44, VEGFA
31	positive regulation of apoptotic process	GO:043065	8.8	ADRB2, KNG1, TSPO, PTPRC, TNF, TP53
32	signal transduction	GO:007165	8.4	TNFSF14, CRH, EGF, HBEGF, HIF1A, CXCL9
33	inflammatory response	GO:006954	8.3	KIT, KNG1, CXCL9, TAC1, TACR1, NGF
34	response to hypoxia	GO:001666	8.2	ADM, TH, HIF1A, NOS2, NOS1, CRP
35	negative regulation of cell proliferation	GO:008285	8.0	ADM, TNF, TP53, IGF1, IGFBP3, IL8
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.4	CASK, TP53, TNF, NOS1, NFKBIA, HIF1A

Molecular functions related to cystitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	8.9	EGF, NGF, IGF1, IL6, IL4, IL11
2	cytokine activity	GO:005125	8.2	IL6, TNF, TNFSF14, CXCL9, IL4, IL1A
3	protein binding	GO:005515	1.2	GAP43, NOS2, NOS1, CRP, CRH, PTPRC