MCID: CYS006
MIFTS: 53

Cystoid Macular Edema malady

Eye diseases category

Summaries for Cystoid Macular Edema

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48OMIM, 34MalaCards
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MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to uveitis and diabetic retinopathy. An important gene associated with Cystoid Macular Edema is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are The phototransduction cascade and Type II interferon signaling (IFNG). The drugs flurbiprofen and flurbiprofen sodium and the compounds bucillamine and betaseron have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Description from OMIM:48 153880

Aliases & Classifications for Cystoid Macular Edema

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 48OMIM, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

cystoid macular edema 9 11
macular edema, cystoid 63


External Ids:

Disease Ontology9 DOID:4447
OMIM48 153880
SNOMED-CT59 193387007
MeSH36 D008269
NCIt41 C34794

Related Diseases for Cystoid Macular Edema

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Symptoms for Cystoid Macular Edema

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48OMIM
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Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cystoid Macular Edema

Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Search CenterWatch for Cystoid Macular Edema

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cystoid Macular Edema

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Anatomical Context for Cystoid Macular Edema

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34MalaCards
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MalaCards organs/tissues related to Cystoid Macular Edema:

34
Eye, Retina, Endothelial, Bone, Bone marrow, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

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38MGI
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Publications for Cystoid Macular Edema

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53PubMed
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Articles related to Cystoid Macular Edema:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Intravitreal diclofenac for refractory uveitic cystoid macular edema. (23825712)
2013
2
Phakic cystoid macular edema secondary to idiopathic macular telangiectasia type 1 responsive to topical anti-inflammatory agents. (23448562)
2013
3
INTRAVITREAL DICLOFENAC VERSUS INTRAVITREAL TRIAMCINOLONE FOR THE TREATMENT OF UVEITIC CYSTOID MACULAR EDEMA. (23584700)
2013
4
Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost. (23901262)
2013
5
Cystoid macular edema secondary to nanoparticle albumin-bound Paclitaxel therapy. (23421925)
2013
6
Selective laser trabeculoplasty complicated by cystoid macular edema: report of two cases. (23225841)
2012
7
Incidence of acute postoperative cystoid macular edema in clinical practice. (23084360)
2012
8
Intravitreal triamcinolone acetonide versus pars plana vitrectomy for pseudophakic cystoid macular edema. (22928501)
2012
9
A case of cystoid macular edema associated with Paclitaxel chemotherapy. (23060727)
2012
10
Efficacy and safety of intravitreal bevacizumab compared with intravitreal and posterior sub-tenon triamcinolone acetonide for treatment of uveitic cystoid macular edema. (20856170)
2011
11
Comparison of serum glycosylated hemoglobin levels in patients with diabetic cystoid macular edema with and without serous macular detachment. (20689191)
2010
12
Cystoid macular edema in uveitis. (20703047)
2010
13
Intravitreal bevacizumab versus triamcinolone acetonide for refractory uveitic cystoid macular edema: a randomized pilot study. (20307215)
2010
14
Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone. (23861610)
2010
15
Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema. (19482498)
2009
16
Serous detachment of macula in cystoid macular edema associated with latanoprost. (18988179)
2008
17
Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery. (18327052)
2008
18
Treatment of cystoid macular edema due to acute posterior multifocal placoid pigment epitheliopathy. (18379948)
2008
19
The effect of topical diclofenac on choroidal blood flow in early postoperative pseudophakias with regard to cystoid macular edema formation. (18055815)
2007
20
Primary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema: pilot study of the Pan-American Collaborative Retina Study Group. (18053911)
2007
21
The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. (16597536)
2006
22
Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. (16546110)
2006
23
Optical coherence tomography and focal electroretinogram evaluation of cystoid macular edema secondary to retinitis pigmentosa treated with intravitreal triamcinolone: case report. (17191201)
2006
24
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
25
Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. (16086944)
2005
26
Pathomechanisms of cystoid macular edema. (15583429)
2004
27
Retinal vasculitis and cystoid macular edema after body tattooing: a case report. (15162298)
2004
28
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. (15596583)
2004
29
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide: case report. (15180250)
2003
30
Managing cystoid macular edema after cataract surgery. (12544809)
2003
31
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide. (14509465)
2003
32
Pars plana vitrectomy for cystoid macular edema secondary to sarcoid uveitis. (11382643)
2001
33
Interferon-associated retinopathy and cystoid macular edema. (11448335)
2001
34
Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study. (11297495)
2001
35
Cystoid macular edema in patients with acquired immune deficiency syndrome and cytomegalovirus retinitis. (11071031)
2000
36
Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. (10541898)
1999
37
Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation. (9715682)
1998
38
Bilateral cystoid macular edema in a 21-year-old woman. (8779089)
1996
39
Pathophysiology and treatment of cystoid macular edema. (8913630)
1996
40
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994
41
Cystoid macular edema. (3420664)
1988
42
Natural course of nonaphakic cystoid macular edema. (6463848)
1984
43
The national, prospective, randomized vitrectomy study for chronic aphakic cystoid macular edema. Progress report and comparison between the control and nonrandomized groups. (6463852)
1984
44
Corneal endothelial cell loss, cystoid macular edema, and iris-supported intraocular lenses. (6472820)
1984
45
Annotated bibliography: cystoid macular edema. (6379954)
1984
46
Pathology of human cystoid macular edema. (6463850)
1984
47
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
48
YAG laser treatment of cystoid macular edema. (6688505)
1983
49
Surgical therapy for chronic aphakic cystoid macular edema. (6752800)
1982
50
Cystoid macular edema after retinal detachment surgery. (7243204)
1980

Variations for Cystoid Macular Edema

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Expression for genes affiliated with Cystoid Macular Edema

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems, 54QIAGEN, 52PharmGKB, 61Thomson Reuters
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Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8RHO, PDE6A
29.6IFNG, CXCL10
39.4IFNG, VEGFA
49.3IL10, IFNG
59.3IFNG, IL10
6
Show member pathways
IL27-mediated signaling events39
9.3IL10, IFNG
7
Show member pathways
9.3IFNG, IL10
89.3IFNG, IL10
99.3IL10, IFNG
109.3IL10, IFNG
119.2PTGS2, VEGFA
12
Show member pathways
S1P2 pathway39
S1P4 pathway39
S1P5 pathway39
S1P1 pathway39
Sphingosine 1-phosphate (S1P) pathway39
9.2PTGS2, VEGFA
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.0IFNG, PTGS2
149.0IFNG, PTGS2
15
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0IL10, IFNG, CXCL10
169.0VEGFA, CXCL12, IFNG
17
Show member pathways
8.9CXCL12, IFNG, IL10
18
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.9RHO, PTGS2, VEGFA
19
Show member pathways
8.6VEGFA, CXCL10, CXCL12, PDE6A, RHO
20
Show member pathways
8.5IL10, IFNG, PTGS2
21
Show member pathways
8.4PTGS2, CXCL10, CXCL12, IL10
22
Show member pathways
7.3IL10, IFNG, CXCL12, CXCL10, PTGS2, VEGFA

Compounds for genes affiliated with Cystoid Macular Edema

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1bucillamine469.7IFNG, VEGFA
2betaseron469.7IL10, IFNG
3groalpha469.7CXCL10, CXCL12, IL10
4interferon gamma469.6IL10, IFNG
5alpha-galactosylceramide469.6IL10, IFNG
62,5-oligoadenylate469.4CXCL10, IFNG, IL10
7polyinosinic-polycytidylic acid469.4CXCL10, IFNG, IL10
8lenalidomide46 1210.4PTGS2, VEGFA
9il 10469.4CXCL10, IFNG, IL10
10ribavirin46 52 1211.4IL10, IFNG, CXCL10
11neopterin469.4IL10, IFNG, CXCL10
12allergens469.4IL10, IFNG, CXCL10
13rolipram46 62 3011.4IFNG, IL10, PDE6A
14misoprostol46 1210.3PTGS2, IL10
15natalizumab46 1210.3IL10, IFNG
16hydrocortisone46 3 62 1212.3CXCL10, IFNG, IL10
17gm-csf46 3010.3VEGFA, IFNG, IL10
18tuberculin469.2IFNG, IL10
19imatinib46 52 1211.2IL10, CXCL12, VEGFA
20heparin46 30 25 1212.2VEGFA, TTF2, CXCL12, RHO
21cyclophosphamide46 52 1211.2VEGFA, CXCL12, IL10
22histamine46 30 2511.1CXCL10, IFNG, IL10, RHO
23tarc469.1CXCL10, CXCL12, IFNG, IL10
24ccl346 3010.1CXCL10, CXCL12, IFNG, IL10
25ifn-alpha469.1CXCL10, CXCL12, IFNG, IL10
26simvastatin46 52 62 30 25 1214.1VEGFA, IFNG, IL10
27endotoxin469.0IL10, IFNG, CXCL10
28glatiramer acetate46 1210.0IFNG, IL10
29infliximab46 52 1211.0VEGFA, CXCL10, IFNG, IL10
30rantes469.0IL10, IFNG, CXCL12, CXCL10
31gemcitabine46 52 1211.0VEGFA, PTGS2, IL10
32triptolide469.0VEGFA, PTGS2, IFNG
33thymidine46 259.9CXCL10, CXCL12, IFNG, IL10
34etanercept46 52 1210.9IL10, IFNG, PTGS2
35rapamycin468.8VEGFA, CXCL12, IFNG, IL10
36herbimycin a46 629.8PTGS2, CXCL12, IFNG
37prostacyclin468.8RHO, IL10, PTGS2, VEGFA
38triamcinolone52 46 30 1211.6VEGFA, PTGS2, CXCL12, IFNG
39actinomycin d468.5VEGFA, PTGS2, CXCL12, IFNG
4015-deoxy-delta-12,14-prostaglandin j2468.5IL10, IFNG, PTGS2, VEGFA
41thalidomide46 52 62 1211.5VEGFA, PTGS2, IFNG, IL10
42estrogen468.5VEGFA, TTF2, PTGS2, CXCL10, CXCL12
43ly294002468.4RHO, IL10, CXCL12, PTGS2, VEGFA
44genistein46 30 62 3 25 1213.3VEGFA, PTGS2, CXCL10, CXCL12, IFNG
45nitric oxide46 25 1210.2TTF2, PTGS2, CXCL10, IFNG, IL10
46sb 20358046 629.1VEGFA, PTGS2, CXCL12, IFNG, IL10
47pge2467.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
48cycloheximide467.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
49dexamethasone46 52 30 1210.4VEGFA, TTF2, PTGS2, CXCL10, CXCL12, IFNG
50vegf467.1RHO, VEGFA, TTF2, PTGS2, CXCL10, CXCL12

GO Terms for genes affiliated with Cystoid Macular Edema

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17Gene Ontology
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Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.5PDE6A, RHO
2external side of plasma membraneGO:0098979.1IFNG, CXCL12, CXCL10
3extracellular spaceGO:0056158.1IL10, IFNG, CXCL12, CXCL10, VEGFA

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:07009810.0CXCL12, CXCL10
2regulation of rhodopsin mediated signaling pathwayGO:02240010.0PDE6A, RHO
3rhodopsin mediated signaling pathwayGO:01605610.0RHO, PDE6A
4positive regulation of axon extension involved in axon guidanceGO:0488429.9CXCL12, VEGFA
5induction of positive chemotaxisGO:0509309.9VEGFA, CXCL12
6blood circulationGO:0080159.8CXCL10, CXCL12
7retina development in camera-type eyeGO:0600419.8RHO, PDE6A
8patterning of blood vesselsGO:0015699.7VEGFA, CXCL12
9positive regulation of MHC class II biosynthetic processGO:0453489.7IL10, IFNG
10response to vitamin DGO:0332809.6PTGS2, CXCL10
11negative regulation of growth of symbiont in hostGO:0441309.6IFNG, IL10
12positive regulation of cell adhesionGO:0457859.6VEGFA, IFNG
13positive regulation of mesenchymal cell proliferationGO:0020539.5VEGFA, IFNG
14positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.5PTGS2, VEGFA
15positive regulation of nitric oxide biosynthetic processGO:0454299.3PTGS2, IFNG
16G-protein coupled receptor signaling pathwayGO:0071869.1RHO, CXCL12, CXCL10
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.8VEGFA, CXCL10, IFNG, IL10
18inflammatory responseGO:0069548.7PTGS2, CXCL10, IL10
19response to drugGO:0424938.5IL10, IFNG, PTGS2

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL12, CXCL10
2growth factor activityGO:0080839.0IL10, CXCL12, VEGFA
3cytokine activityGO:0051258.6IL10, IFNG, VEGFA

Products for genes affiliated with Cystoid Macular Edema

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  • Antibodies
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Sources for Cystoid Macular Edema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet