MCID: CYS006
MIFTS: 48

Cystoid Macular Edema malady

Summaries for Cystoid Macular Edema

Sources:
47OMIM, 33MalaCards
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MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to uveitis and acquired immunodeficiency syndrome. An important gene associated with Cystoid Macular Edema is PDE6G (phosphodiesterase 6G, cGMP-specific, rod, gamma), and among its related pathways are Visual phototransduction and Visual signal transduction- Rods. The drugs flurbiprofen and flurbiprofen sodium and the compounds rolipram and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and retina, and related mouse phenotypes are no phenotypic analysis and nervous system.

Description from OMIM:47 153880

Aliases & Classifications for Cystoid Macular Edema

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 35MeSH
See all sources

Aliases & Descriptions:

cystoid macular edema 8 10
macular edema, cystoid 61


External Ids:

Disease Ontology8 DOID:4447
NCIt40 C34794
SNOMED-CT57 193387007
OMIM47 153880
MeSH35 D008269

Related Diseases for Cystoid Macular Edema

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Clinical Features for Cystoid Macular Edema

Sources:
47OMIM
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Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cystoid Macular Edema

Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Search CenterWatch for Cystoid Macular Edema

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cystoid Macular Edema

Anatomical Context for Cystoid Macular Edema

Sources:
33MalaCards
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MalaCards organs/tissues related to Cystoid Macular Edema:

33
Bone marrow, Whole blood, Retina, Myeloid, T cells, Endothelial

Animal Models for Cystoid Macular Edema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Cystoid Macular Edema

Sources:
51PubMed
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Articles related to Cystoid Macular Edema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Intravitreal diclofenac for refractory uveitic cystoid macular edema. (23825712)
2013
2
Cystoid macular edema induced by low doses of nicotinic Acid. (23662229)
2013
3
Dexamethasone intravitreal implant for treatment of uveitic persistent cystoid macular edema in vitrectomized patients. (23514796)
2013
4
Intravitreal triamcinolone acetonide versus pars plana vitrectomy for pseudophakic cystoid macular edema. (22928501)
2012
5
Long-term follow-up of inflammatory cystoid macular edema. (22481481)
2012
6
SD-OCT pattern of retinal venous occlusion with cystoid macular edema treated with OzurdexAr. (21500185)
2011
7
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. (21573094)
2011
8
Pseudophakic cystoid macular edema associated with extrafoveal vitreoretinal traction. (21643426)
2011
9
Toxic anterior segment syndrome presenting as isolated cystoid macular edema after removal of entrapped ophthalmic ointment. (20670090)
2010
10
Cystoid macular edema and visual loss as sequelae to interferon alpha treatment of systemic hepatitis C. (20195039)
2010
11
Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema. (19482498)
2009
12
Successful treatment of cystoid macular edema with valdecoxib. (17964375)
2007
13
Rebound of cystoid macular edema with continued use of acetazolamide in patients with retinitis pigmentosa. (18040255)
2007
14
A case of cystoid macular edema treated by intravitreal triamcinolone in a patient with systemic lupus erythematosis. (17416949)
2006
15
Long-term visual outcomes of vitrectomy for cystoid macular edema due to nonischemic central retinal vein occlusion. (17191190)
2006
16
Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. (16086944)
2005
17
Postoperative subretinal fluid associated with cystoid macular edema following cataract surgery. (15689820)
2005
18
Cystoid macular edema associated with latanoprost after uncomplicated cataract surgery. (15751259)
2005
19
Long-term effect of acetazolamide treatment of patients with uveitic chronic cystoid macular edema is limited by persisting inflammation. (15689809)
2005
20
Trace microalbuminuria in inflammatory cystoid macular edema. (15629293)
2004
21
Pseudophakic cystoid macular edema. (12759847)
2002
22
Deflazacort treatment of cystoid macular edema in patients affected by Retinitis Pigmentosa: a pilot study. (12608650)
2002
23
Postcataract cystoid macular edema. (11787744)
2001
24
Latanoprost and cystoid macular edema in high-risk aphakic or pseudophakic eyes. (11566522)
2001
25
Enhanced disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema by topical timolol and its preservative in early postoperative pseudophakia. (11231772)
2001
26
Cystoid macular edema associated with the use of latanoprost. (9549261)
1998
27
Efficacy of dorzolamide hydrochloride in the management of chronic cystoid macular edema in patients with retinitis pigmentosa. (9196934)
1997
28
Effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of cystoid macular edema after cataract surgery. (9279674)
1996
29
Cystoid macular edema. (8963073)
1996
30
Aggravation of laser-treated diabetic cystoid macular edema after prolonged flight: a case report. (7619038)
1995
31
Retinal trypsin digest study of cystoid macular edema associated with peripheral choroidal melanoma. (7832220)
1995
32
Cystoid macular edema in anterior chamber lens implantation following posterior capsule rupture. (1483373)
1992
33
A direct correlation of the resolution of pseudophakic cystoid macular edema with acetazolamide therapy. (2064253)
1991
34
The putative role of prostaglandins in cystoid macular edema. (2678143)
1989
35
Cystoid macular edema following epikeratophakia. (3057919)
1988
36
A prospective study of cystoid macular edema after neodymium: YAG laser posterior capsulotomy. (3601362)
1987
37
Intraocular lens implant exchange and resolution of cystoid macular edema. (3701638)
1986
38
Changes in the retinal pigment epithelium associated with cystoid macular edema. (3590473)
1986
39
Aphakic cystoid macular edema. A hypothesis. (4026641)
1985
40
Near-UV radiation from the operating microscope and pseudophakic cystoid macular edema. (3883964)
1985
41
Pars plana vitrectomy for aphakic cystoid macular edema. (4001583)
1985
42
Effect of an ultraviolet-filtering intraocular lens on cystoid macular edema. (3991126)
1985
43
Annotated bibliography: cystoid macular edema. (6379954)
1984
44
Pathology of human cystoid macular edema. (6463850)
1984
45
Indomethacin in the treatment of postoperative cystoid macular edema. (6379953)
1984
46
Retinal edema. Introduction to the First International Cystoid Macular Edema Symposium. (6463845)
1984
47
First International Cystoid Macular Edema Symposium. Sarasota, Florida, April 1983. (6463844)
1984
48
Cystoid macular edema following laser iridotomy. (6838095)
1983
49
Aphakic cystoid macular edema: occurrence in infants and children after transpupillary lensectomy and anterior vitrectomy. (7082204)
1982
50
Retinal light exposure and cystoid macular edema. (7387520)
1980

Genetic Variations for Cystoid Macular Edema

Expression for genes affiliated with Cystoid Macular Edema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 53R&D Systems, 12EMD Millipore
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Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6PDE6G, PDE6A, RHO
2
Hide members
9.6PDE6G, PDE6A, RHO
39.6RHO, PDE6A, PDE6G
4
Hide members
9.5IL10, IFNG
5
Hide members
9.4PTGS2, CXCL12, CXCL10
69.1CXCL10, HLA-B, IFNG
7
Hide members
8.6IFNG, HLA-B, CXCL12, IL10
8
Hide members
8.5PTGS2, VEGFA, HLA-B, IFNG

Compounds for genes affiliated with Cystoid Macular Edema

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rolipram45 60 2912.3PDE6A, PDE6G
2cycloheximide4510.3CXCL12, CXCL10
3pge24510.1PTGS2, VEGFA
4tacrolimus45 50 1112.1CXCL10, IFNG
52,5-oligoadenylate4510.0HLA-B, CXCL10
6gm-csf45 2910.9IFNG, IL10
7lenalidomide45 1110.9PTGS2, VEGFA
8bucillamine459.9IFNG, VEGFA
9betaseron459.9IFNG, IL10
10(r)-(-)-rolipram609.9PDE6A, PDE6G
11interferon gamma459.9IL10, IFNG
12misoprostol45 1110.9IL10, PTGS2
13groalpha459.8IL10, CXCL12, CXCL10
14alpha-galactosylceramide459.8IL10, IFNG
15dexamethasone45 50 29 1112.8VEGFA, CXCL12, PTGS2
16glatiramer acetate45 1110.7IFNG, IL10
17tuberculin459.7IFNG, IL10
18natalizumab45 1110.7IFNG, IL10
19cobalt chloride459.7IFNG, VEGFA
20il 10459.6IL10, CXCL10, IFNG
21neopterin459.6IL10, CXCL10, IFNG
22allergens459.6IFNG, CXCL10, IL10
23gemcitabine45 50 1111.5VEGFA, IL10, PTGS2
24triptolide459.5IFNG, VEGFA, PTGS2
25etanercept45 50 1111.5IFNG, IL10, PTGS2
26mdms459.4IL10, CXCL12
27rantes459.4IFNG, HLA-B, CXCL12
28tarc459.4IFNG, CXCL10, CXCL12, IL10
29ccl345 2910.4IFNG, CXCL10, CXCL12, IL10
30ifn-alpha459.4IFNG, CXCL10, CXCL12, IL10
31infliximab45 50 1111.3IFNG, VEGFA, CXCL10, IL10
32prostacyclin459.3RHO, VEGFA, IL10, PTGS2
33histamine45 29 2411.3IL10, CXCL10, RHO, IFNG
34cyclosporin a45 29 6011.3IFNG, HLA-B, TTF2
35simvastatin45 50 60 29 11 2414.2IL10, VEGFA, IFNG
36triamcinolone45 50 29 1112.2PTGS2, CXCL12, VEGFA, IFNG
37gtp45 2910.2TTF2, CXCL12, RHO, HLA-B
38herbimycin a45 6010.2IFNG, CXCL12, PTGS2
39rapamycin459.1IFNG, VEGFA, CXCL12, IL10
4015-deoxy-delta-12,14-prostaglandin j2459.1PTGS2, IL10, VEGFA, IFNG
41thalidomide45 50 60 1112.1PTGS2, IL10, VEGFA, IFNG
42polyinosinic-polycytidylic acid459.1IFNG, HLA-B, CXCL10, IL10
43ribavirin45 50 1111.1IL10, CXCL10, HLA-B, IFNG
44actinomycin d459.1IFNG, VEGFA, CXCL12, PTGS2
45ly294002459.0PTGS2, IL10, CXCL12, VEGFA, RHO
46genistein45 29 60 2 11 2413.9IFNG, VEGFA, CXCL10, CXCL12, PTGS2
47thymidine45 249.8IL10, CXCL12, CXCL10, IFNG
48sb 20358045 609.8IFNG, VEGFA, CXCL12, IL10, PTGS2
49nitric oxide45 11 2410.3IFNG, HLA-B, CXCL10, IL10, TTF2, PTGS2
50vegf458.0IFNG, RHO, VEGFA, CXCL10, CXCL12, IL10

GO Terms for genes affiliated with Cystoid Macular Edema

Sources:
16Gene Ontology
See all sources

Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.3RHO, PDE6A, PDE6G
2extracellular spaceGO:0056158.6IL10, CXCL12, CXCL10, VEGFA, IFNG

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:0224009.8RHO, PDE6A, PDE6G
2positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.8PTGS2, VEGFA
3induction of positive chemotaxisGO:0509309.8CXCL12, VEGFA
4rhodopsin mediated signaling pathwayGO:0160569.7RHO, PDE6A, PDE6G
5response to vitamin DGO:0332809.7CXCL10, PTGS2
6positive regulation of MHC class II biosynthetic processGO:0453489.6IFNG, IL10
7phototransduction, visible lightGO:0076039.6RHO, PDE6A, PDE6G
8negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-GMP phosphodiesterase activityGO:0475559.8PDE6A, PDE6G
2cytokine activityGO:0051259.2IL10, VEGFA, IFNG
3growth factor activityGO:0080839.0IL10, CXCL12, VEGFA

Products for genes affiliated with Cystoid Macular Edema

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystoid Macular Edema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet