MCID: CYS006
MIFTS: 50

Cystoid Macular Edema malady

Summaries for Cystoid Macular Edema

About this section
Sources:
46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to retinitis and macular retinal edema. An important gene associated with Cystoid Macular Edema is PDE6G (phosphodiesterase 6G, cGMP-specific, rod, gamma), and among its related pathways are Visual phototransduction and Visual signal transduction- Rods. The drugs flurbiprofen and flurbiprofen sodium and the compounds rolipram and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are no phenotypic analysis and nervous system.

Description from OMIM:46 153880

Aliases & Classifications for Cystoid Macular Edema

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH
See all sources

Aliases & Descriptions:

cystoid macular edema 8 10
macular edema, cystoid 60


External Ids:

Disease Ontology8 DOID:4447
NCIt39 C34794
SNOMED-CT56 193387007
OMIM46 153880
MeSH34 D008269

Related Diseases for Cystoid Macular Edema

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cystoid Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.7RHO
2macular retinal edema31.7CXCL12, VEGFA
3uveitis31.4IFNG, HLA-B, RHO, CXCL10, IL10
4retinal vein occlusion31.3VEGFA
5retinal detachment31.0VEGFA
6glaucoma30.8TTF2
7diabetic retinopathy30.7CXCL12, VEGFA, RHO
8melanoma30.6IFNG, HLA-B, RHO, VEGFA, CXCL10, IL10
9retinopathy of prematurity30.5VEGFA
10acquired immunodeficiency syndrome30.5HLA-B, CXCL12
11vasculitis30.3HLA-B
12keratitis30.3VEGFA
13endophthalmitis30.3VEGFA
14adenoma30.3PTGS2, HLA-B
15hepatitis30.3TTF2, CXCL12, CXCL10, HLA-B
16hepatitis c30.3IFNG, CXCL10, IL10
17multiple sclerosis30.3IFNG, HLA-B, CXCL10, CXCL12, IL10
18cataract11.0
19retinitis pigmentosa10.9
20diabetic macular edema10.9
21choroiditis10.7
22central retinal vein occlusion10.7
23macular holes10.6
24corneal edema10.5
25gyrate atrophy10.4
26ocular hypertension10.4
27poems syndrome10.4
28posterior uveitis10.4
29hypertension10.4
30intermediate uveitis10.4
31neuropathy10.4
32ocular hypotension10.4
33papilledema10.4
34cystoid macular dystrophy10.4
35age related macular degeneration10.2
36central retinal artery occlusion10.2
37crohn's disease10.2
38iritis10.2
39cycloplegia10.2
40danon disease10.2
41bullous keratopathy10.2
42ischemic neuropathy10.2
43coats disease10.2
44lyme disease10.2
45retinal melanoma10.2
46macular keratitis10.2
47preretinal fibrosis10.2
48churg-strauss syndrome10.2
49vitelliform macular dystrophy10.2
50ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Clinical Features for Cystoid Macular Edema

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cystoid Macular Edema

Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Search CenterWatch for Cystoid Macular Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cystoid Macular Edema

About this section

Anatomical Context for Cystoid Macular Edema

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cystoid Macular Edema:

32
Eye, Retina, Endothelial, Bone marrow, Bone, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cystoid Macular Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9PTGS2, RHO
2MP:00036319.8RHO, PDE6A, PDE6G
3MP:00053919.7PDE6G, PDE6A, RHO
4MP:00053708.4PTGS2, IL10, CXCL12, VEGFA, IFNG
5MP:00053857.7IFNG, RHO, VEGFA, CXCL10, CXCL12, IL10
6MP:00053977.2IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
7MP:00053846.9IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
8MP:00053876.8IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12

Publications for Cystoid Macular Edema

About this section
Sources:
50PubMed
See all sources

Articles related to Cystoid Macular Edema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
INTRAVITREAL DICLOFENAC VERSUS INTRAVITREAL TRIAMCINOLONE FOR THE TREATMENT OF UVEITIC CYSTOID MACULAR EDEMA. (23584700)
2013
2
Influence of Orthostasis and Daytime on Retinal Thickness in Uveitis-Associated Cystoid Macular Edema. (24215573)
2013
3
Incidence of acute postoperative cystoid macular edema in clinical practice. (23084360)
2012
4
Cystoid macular edema in acute presentation of central retinal artery occlusion. (22606497)
2012
5
The natural history of tractional cystoid macular edema. (22718150)
2012
6
Prophylaxis of pseudophakic cystoid macular edema with intraoperative pegaptanib. (21923279)
2012
7
Cystoid macular edema as the initial manifestation of choroidal melanoma. (23440248)
2012
8
Fluocinolone acetonide implant (Retisert) for chronic cystoid macular edema in two patients with AIDS and a history of cytomegalovirus retinitis. (21595537)
2011
9
Tangential vitreous traction: a possible mechanism of development of cystoid macular edema in retinitis pigmentosa. (21386918)
2011
10
Resolution of pseudophakic cystoid macular edema with combination therapy of topical corticosteroids and nonsteroidal anti-inflammatory drugs. (22220453)
2011
11
Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening. (21314440)
2011
12
Prostaglandin-induced cystoid macular edema following routine cataract extraction. (21076526)
2010
13
Intravitreal ranibizumab in the treatment of cystoid macular edema associated with retinitis pigmentosa. (20925582)
2010
14
Intravitreal pegaptanib sodium (Macugen) for refractory cystoid macular edema in pericentral retinitis pigmentosa. (18157710)
2009
15
Intravitreal bevacizumab (Avastin) for the treatment of cystoid macular edema in BehAset disease. (19294576)
2009
16
Treatment of cystoid macular edema due to acute posterior multifocal placoid pigment epitheliopathy. (18379948)
2008
17
Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis. (18321467)
2008
18
Cystoid macular edema with docetaxel chemotherapy and the fluid retention syndrome. (17763235)
2007
19
Intravitreal injection of bevacizumab for cystoid macular edema in retinitis pigmentosa. (17313405)
2007
20
Evaluation of costs for cystoid macular edema among patients after cataract surgery. (17558326)
2007
21
Intravitreal triamcinolone for cystoid macular edema related to branch retinal vein occlusion. (17726219)
2006
22
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
23
Bilateral retinal venous occlusion and unilateral cystoid macular edema in Churg-Strauss syndrome treated with intravitreal triamcinolone. (16077365)
2005
24
Infliximab for chronic cystoid macular edema associated with uveitis. (15488796)
2004
25
Choroiditis, pigment epithelial detachment, and cystoid macular edema as complications of poststreptococcal syndrome. (15300115)
2004
26
Cystoid macular edema associated with latanoprost use in a pseudophakic eye with a history of surgical complications. (12586189)
2003
27
A case of cystoid macular edema associated with latanoprost ophthalmic solution. (12543193)
2002
28
Intravitreal triamcinolone for refractory cystoid macular edema secondary to birdshot retinochoroidopathy. (11545651)
2001
29
Cystoid macular edema associated with topical latanoprost in glaucomatous eyes with a normally functioning blood-ocular barrier. (11442189)
2001
30
Visually significant cystoid macular edema in pseudophakic and aphakic patients with glaucoma receiving latanoprost. (10958605)
2000
31
Latanoprost and cystoid macular edema: is there a causal relation? (10848227)
2000
32
Cystoid macular edema in a patient with acquired immunodeficiency syndrome and past ocular history of cytomegalovirus retinitis after initiation of protease inhibitors. (10896344)
1999
33
Infrared imaging of cystoid macular edema. (10541899)
1999
34
A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. (8684794)
1996
35
Capillary blood flow velocity measurements in cystoid macular edema with the scanning laser ophthalmoscope. (8291589)
1994
36
Cystoid macular edema associated with topical echothiophate iodide. (8129329)
1993
37
Corticosteroid-induced ocular hypertension in the treatment of aphakic or pseudophakic cystoid macular edema. (8437822)
1993
38
Epiretinal membranes and cystoid macular edema in gyrate atrophy of the choroid and retina. (2772421)
1989
39
Cystoid macular edema in pediatric aphakia. (3171831)
1988
40
Cystoid macular edema diagnosis, prognosis, and management. (4012830)
1985
41
Occurrence of cystoid macular edema after Q switched Nd Y.A.G. laser capsulotomy. (3842943)
1985
42
The national, prospective, randomized vitrectomy study for chronic aphakic cystoid macular edema. Progress report and comparison between the control and nonrandomized groups. (6463852)
1984
43
Intraretinal hemorrhages in cystoid macular edema. (6466176)
1984
44
Aphakic cystoid macular edema. Longterm clinical observations. (6463846)
1984
45
Cystoid macular edema in pseudophakia. (6463847)
1984
46
YAG laser treatment of cystoid macular edema. (6688505)
1983
47
Surgical therapy for chronic aphakic cystoid macular edema. (6752800)
1982
48
Incidence of aphakic cystoid macular edema with the use of topical indomethacin. (7029388)
1981
49
Cystoid macular edema following secondary lens implantation. (7228801)
1981
50
Vitrectomy and cystoid macular edema. (6995896)
1980

Genetic Variations for Cystoid Macular Edema

About this section

Expression for genes affiliated with Cystoid Macular Edema

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6PDE6G, PDE6A, RHO
2
Hide members
9.6PDE6G, PDE6A, RHO
39.6RHO, PDE6A, PDE6G
4
Hide members
9.5IL10, IFNG
5
Hide members
9.4PTGS2, CXCL12, CXCL10
69.1CXCL10, HLA-B, IFNG
7
Hide members
8.6IFNG, HLA-B, CXCL12, IL10
8
Hide members
8.5PTGS2, VEGFA, HLA-B, IFNG

Compounds for genes affiliated with Cystoid Macular Edema

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.3PDE6A, PDE6G
2cycloheximide4410.3CXCL12, CXCL10
3pge24410.1VEGFA, PTGS2
4tacrolimus44 49 1112.1IFNG, CXCL10
52,5-oligoadenylate4410.0CXCL10, HLA-B
6gm-csf44 2810.9IFNG, IL10
7lenalidomide44 1110.9VEGFA, PTGS2
8bucillamine449.9IFNG, VEGFA
9betaseron449.9IL10, IFNG
10(r)-(-)-rolipram599.9PDE6A, PDE6G
11interferon gamma449.9IL10, IFNG
12misoprostol44 1110.9IL10, PTGS2
13groalpha449.8IL10, CXCL12, CXCL10
14alpha-galactosylceramide449.8IFNG, IL10
15dexamethasone44 49 28 1112.8CXCL12, PTGS2, VEGFA
16glatiramer acetate44 1110.7IL10, IFNG
17tuberculin449.7IL10, IFNG
18cobalt chloride449.7VEGFA, IFNG
19natalizumab44 1110.7IL10, IFNG
20il 10449.6IL10, CXCL10, IFNG
21neopterin449.6CXCL10, IL10, IFNG
22allergens449.6IFNG, CXCL10, IL10
23gemcitabine44 49 1111.5PTGS2, IL10, VEGFA
24triptolide449.5PTGS2, IFNG, VEGFA
25etanercept44 49 1111.5PTGS2, IFNG, IL10
26mdms449.4CXCL12, IL10
27rantes449.4IFNG, HLA-B, CXCL12
28tarc449.4IFNG, CXCL10, CXCL12, IL10
29ccl344 2810.4IFNG, CXCL10, IL10, CXCL12
30ifn-alpha449.4CXCL12, IFNG, CXCL10, IL10
31infliximab44 49 1111.3CXCL10, IL10, VEGFA, IFNG
32prostacyclin449.3PTGS2, IL10, VEGFA, RHO
33histamine44 28 2411.3IFNG, RHO, CXCL10, IL10
34cyclosporin a44 28 5911.3IFNG, HLA-B, TTF2
35simvastatin44 49 59 28 11 2414.2IFNG, VEGFA, IL10
36triamcinolone44 49 28 1112.2CXCL12, PTGS2, VEGFA, IFNG
37gtp44 2810.2TTF2, HLA-B, CXCL12, RHO
38herbimycin a44 5910.2PTGS2, IFNG, CXCL12
39rapamycin449.1IL10, CXCL12, VEGFA, IFNG
4015-deoxy-delta-12,14-prostaglandin j2449.1IFNG, PTGS2, IL10, VEGFA
41thalidomide44 49 59 1112.1IL10, IFNG, PTGS2, VEGFA
42polyinosinic-polycytidylic acid449.1IL10, HLA-B, IFNG, CXCL10
43ribavirin44 49 1111.1CXCL10, IL10, HLA-B, IFNG
44actinomycin d449.1VEGFA, CXCL12, PTGS2, IFNG
45ly294002449.0VEGFA, PTGS2, IL10, CXCL12, RHO
46genistein44 28 59 2 11 2413.9PTGS2, IFNG, CXCL10, CXCL12, VEGFA
47thymidine44 249.8CXCL12, IL10, IFNG, CXCL10
48sb 20358044 599.8VEGFA, IFNG, CXCL12, PTGS2, IL10
49nitric oxide44 11 2410.3HLA-B, IL10, CXCL10, IFNG, PTGS2, TTF2
50vegf448.0IFNG, TTF2, IL10, PTGS2, CXCL12, CXCL10

GO Terms for genes affiliated with Cystoid Macular Edema

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.3RHO, PDE6A, PDE6G
2extracellular spaceGO:0056158.6IL10, CXCL12, CXCL10, VEGFA, IFNG

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:0224009.8RHO, PDE6A, PDE6G
2positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.8PTGS2, VEGFA
3induction of positive chemotaxisGO:0509309.8CXCL12, VEGFA
4rhodopsin mediated signaling pathwayGO:0160569.7RHO, PDE6A, PDE6G
5response to vitamin DGO:0332809.7CXCL10, PTGS2
6positive regulation of MHC class II biosynthetic processGO:0453489.6IFNG, IL10
7phototransduction, visible lightGO:0076039.6RHO, PDE6A, PDE6G
8negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-GMP phosphodiesterase activityGO:0475559.8PDE6A, PDE6G
2cytokine activityGO:0051259.2IL10, VEGFA, IFNG
3growth factor activityGO:0080839.0IL10, CXCL12, VEGFA

Products for genes affiliated with Cystoid Macular Edema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystoid Macular Edema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet