MCID: CYS006
MIFTS: 53

Cystoid Macular Edema malady

Eye diseases category
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Summaries for Cystoid Macular Edema

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47OMIM, 33MalaCards
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MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to uveitis and diabetic retinopathy. An important gene associated with Cystoid Macular Edema is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are The phototransduction cascade and Type II interferon signaling (IFNG). The drugs flurbiprofen and flurbiprofen sodium and the compounds bucillamine and betaseron have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Description from OMIM:47 153880

Aliases & Classifications for Cystoid Macular Edema

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8Disease Ontology, 10DISEASES, 62UMLS, 47OMIM, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

cystoid macular edema 8 10
macular edema, cystoid 62


External Ids:

Disease Ontology8 DOID:4447
OMIM47 153880
SNOMED-CT58 193387007
MeSH35 D008269
NCIt40 C34794

Related Diseases for Cystoid Macular Edema

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Symptoms for Cystoid Macular Edema

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47OMIM
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Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Cystoid Macular Edema

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Anatomical Context for Cystoid Macular Edema

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33MalaCards
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MalaCards organs/tissues related to Cystoid Macular Edema:

33
Eye, Retina, Endothelial, Bone, Bone marrow, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

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37MGI
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Publications for Cystoid Macular Edema

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52PubMed
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Articles related to Cystoid Macular Edema:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Intravitreal diclofenac for refractory uveitic cystoid macular edema. (23825712)
2013
2
Phakic cystoid macular edema secondary to idiopathic macular telangiectasia type 1 responsive to topical anti-inflammatory agents. (23448562)
2013
3
INTRAVITREAL DICLOFENAC VERSUS INTRAVITREAL TRIAMCINOLONE FOR THE TREATMENT OF UVEITIC CYSTOID MACULAR EDEMA. (23584700)
2013
4
Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost. (23901262)
2013
5
Cystoid macular edema secondary to nanoparticle albumin-bound Paclitaxel therapy. (23421925)
2013
6
Selective laser trabeculoplasty complicated by cystoid macular edema: report of two cases. (23225841)
2012
7
Incidence of acute postoperative cystoid macular edema in clinical practice. (23084360)
2012
8
Intravitreal triamcinolone acetonide versus pars plana vitrectomy for pseudophakic cystoid macular edema. (22928501)
2012
9
A case of cystoid macular edema associated with Paclitaxel chemotherapy. (23060727)
2012
10
Efficacy and safety of intravitreal bevacizumab compared with intravitreal and posterior sub-tenon triamcinolone acetonide for treatment of uveitic cystoid macular edema. (20856170)
2011
11
Comparison of serum glycosylated hemoglobin levels in patients with diabetic cystoid macular edema with and without serous macular detachment. (20689191)
2010
12
Cystoid macular edema in uveitis. (20703047)
2010
13
Intravitreal bevacizumab versus triamcinolone acetonide for refractory uveitic cystoid macular edema: a randomized pilot study. (20307215)
2010
14
Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone. (23861610)
2010
15
Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema. (19482498)
2009
16
Serous detachment of macula in cystoid macular edema associated with latanoprost. (18988179)
2008
17
Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery. (18327052)
2008
18
Treatment of cystoid macular edema due to acute posterior multifocal placoid pigment epitheliopathy. (18379948)
2008
19
The effect of topical diclofenac on choroidal blood flow in early postoperative pseudophakias with regard to cystoid macular edema formation. (18055815)
2007
20
Primary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema: pilot study of the Pan-American Collaborative Retina Study Group. (18053911)
2007
21
The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. (16597536)
2006
22
Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. (16546110)
2006
23
Optical coherence tomography and focal electroretinogram evaluation of cystoid macular edema secondary to retinitis pigmentosa treated with intravitreal triamcinolone: case report. (17191201)
2006
24
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
25
Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. (16086944)
2005
26
Pathomechanisms of cystoid macular edema. (15583429)
2004
27
Retinal vasculitis and cystoid macular edema after body tattooing: a case report. (15162298)
2004
28
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone. (15596583)
2004
29
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide: case report. (15180250)
2003
30
Managing cystoid macular edema after cataract surgery. (12544809)
2003
31
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide. (14509465)
2003
32
Pars plana vitrectomy for cystoid macular edema secondary to sarcoid uveitis. (11382643)
2001
33
Interferon-associated retinopathy and cystoid macular edema. (11448335)
2001
34
Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study. (11297495)
2001
35
Cystoid macular edema in patients with acquired immune deficiency syndrome and cytomegalovirus retinitis. (11071031)
2000
36
Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. (10541898)
1999
37
Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation. (9715682)
1998
38
Bilateral cystoid macular edema in a 21-year-old woman. (8779089)
1996
39
Pathophysiology and treatment of cystoid macular edema. (8913630)
1996
40
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994
41
Cystoid macular edema. (3420664)
1988
42
Natural course of nonaphakic cystoid macular edema. (6463848)
1984
43
The national, prospective, randomized vitrectomy study for chronic aphakic cystoid macular edema. Progress report and comparison between the control and nonrandomized groups. (6463852)
1984
44
Corneal endothelial cell loss, cystoid macular edema, and iris-supported intraocular lenses. (6472820)
1984
45
Annotated bibliography: cystoid macular edema. (6379954)
1984
46
Pathology of human cystoid macular edema. (6463850)
1984
47
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
48
YAG laser treatment of cystoid macular edema. (6688505)
1983
49
Surgical therapy for chronic aphakic cystoid macular edema. (6752800)
1982
50
Cystoid macular edema after retinal detachment surgery. (7243204)
1980

Variations for Cystoid Macular Edema

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Expression for genes affiliated with Cystoid Macular Edema

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 54R&D Systems, 53QIAGEN, 51PharmGKB, 60Thomson Reuters
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Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8RHO, PDE6A
29.6IFNG, CXCL10
39.4IFNG, VEGFA
49.3IL10, IFNG
59.3IFNG, IL10
6
Show member pathways
IL27-mediated signaling events38
9.3IL10, IFNG
7
Show member pathways
9.3IFNG, IL10
89.3IFNG, IL10
99.3IL10, IFNG
109.3IL10, IFNG
119.2PTGS2, VEGFA
12
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.2PTGS2, VEGFA
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.0IFNG, PTGS2
149.0IFNG, PTGS2
15
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IL10, IFNG, CXCL10
169.0VEGFA, CXCL12, IFNG
17
Show member pathways
8.9CXCL12, IFNG, IL10
18
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.9RHO, PTGS2, VEGFA
19
Show member pathways
8.6VEGFA, CXCL10, CXCL12, PDE6A, RHO
20
Show member pathways
8.5IL10, IFNG, PTGS2
21
Show member pathways
8.4PTGS2, CXCL10, CXCL12, IL10
22
Show member pathways
7.3IL10, IFNG, CXCL12, CXCL10, PTGS2, VEGFA

Compounds for genes affiliated with Cystoid Macular Edema

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1bucillamine459.7IFNG, VEGFA
2betaseron459.7IL10, IFNG
3groalpha459.7CXCL10, CXCL12, IL10
4interferon gamma459.6IL10, IFNG
5alpha-galactosylceramide459.6IL10, IFNG
62,5-oligoadenylate459.4CXCL10, IFNG, IL10
7polyinosinic-polycytidylic acid459.4CXCL10, IFNG, IL10
8lenalidomide45 1110.4PTGS2, VEGFA
9il 10459.4CXCL10, IFNG, IL10
10ribavirin45 51 1111.4IL10, IFNG, CXCL10
11neopterin459.4IL10, IFNG, CXCL10
12allergens459.4IL10, IFNG, CXCL10
13rolipram45 61 2911.4IFNG, IL10, PDE6A
14misoprostol45 1110.3PTGS2, IL10
15natalizumab45 1110.3IL10, IFNG
16hydrocortisone45 3 61 1112.3CXCL10, IFNG, IL10
17gm-csf45 2910.3VEGFA, IFNG, IL10
18tuberculin459.2IFNG, IL10
19imatinib45 51 1111.2IL10, CXCL12, VEGFA
20heparin45 29 24 1112.2VEGFA, TTF2, CXCL12, RHO
21cyclophosphamide45 51 1111.2VEGFA, CXCL12, IL10
22histamine45 29 2411.1CXCL10, IFNG, IL10, RHO
23tarc459.1CXCL10, CXCL12, IFNG, IL10
24ccl345 2910.1CXCL10, CXCL12, IFNG, IL10
25ifn-alpha459.1CXCL10, CXCL12, IFNG, IL10
26simvastatin45 51 61 29 24 1114.1VEGFA, IFNG, IL10
27endotoxin459.0IL10, IFNG, CXCL10
28glatiramer acetate45 1110.0IFNG, IL10
29infliximab45 51 1111.0VEGFA, CXCL10, IFNG, IL10
30rantes459.0IL10, IFNG, CXCL12, CXCL10
31gemcitabine45 51 1111.0VEGFA, PTGS2, IL10
32triptolide459.0VEGFA, PTGS2, IFNG
33thymidine45 249.9CXCL10, CXCL12, IFNG, IL10
34etanercept45 51 1110.9IL10, IFNG, PTGS2
35rapamycin458.8VEGFA, CXCL12, IFNG, IL10
36herbimycin a45 619.8PTGS2, CXCL12, IFNG
37prostacyclin458.8RHO, IL10, PTGS2, VEGFA
38triamcinolone51 45 29 1111.6VEGFA, PTGS2, CXCL12, IFNG
39actinomycin d458.5VEGFA, PTGS2, CXCL12, IFNG
4015-deoxy-delta-12,14-prostaglandin j2458.5IL10, IFNG, PTGS2, VEGFA
41thalidomide45 51 61 1111.5VEGFA, PTGS2, IFNG, IL10
42estrogen458.5VEGFA, TTF2, PTGS2, CXCL10, CXCL12
43ly294002458.4RHO, IL10, CXCL12, PTGS2, VEGFA
44genistein45 29 61 3 24 1113.3VEGFA, PTGS2, CXCL10, CXCL12, IFNG
45nitric oxide45 24 1110.2TTF2, PTGS2, CXCL10, IFNG, IL10
46sb 20358045 619.1VEGFA, PTGS2, CXCL12, IFNG, IL10
47pge2457.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
48cycloheximide457.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
49dexamethasone45 51 29 1110.4VEGFA, TTF2, PTGS2, CXCL10, CXCL12, IFNG
50vegf457.1RHO, VEGFA, TTF2, PTGS2, CXCL10, CXCL12

GO Terms for genes affiliated with Cystoid Macular Edema

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16Gene Ontology
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Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.5PDE6A, RHO
2external side of plasma membraneGO:0098979.1IFNG, CXCL12, CXCL10
3extracellular spaceGO:0056158.1IL10, IFNG, CXCL12, CXCL10, VEGFA

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:07009810.0CXCL12, CXCL10
2regulation of rhodopsin mediated signaling pathwayGO:02240010.0PDE6A, RHO
3rhodopsin mediated signaling pathwayGO:01605610.0RHO, PDE6A
4positive regulation of axon extension involved in axon guidanceGO:0488429.9CXCL12, VEGFA
5induction of positive chemotaxisGO:0509309.9VEGFA, CXCL12
6blood circulationGO:0080159.8CXCL10, CXCL12
7retina development in camera-type eyeGO:0600419.8RHO, PDE6A
8patterning of blood vesselsGO:0015699.7VEGFA, CXCL12
9positive regulation of MHC class II biosynthetic processGO:0453489.7IL10, IFNG
10response to vitamin DGO:0332809.6PTGS2, CXCL10
11negative regulation of growth of symbiont in hostGO:0441309.6IFNG, IL10
12positive regulation of cell adhesionGO:0457859.6VEGFA, IFNG
13positive regulation of mesenchymal cell proliferationGO:0020539.5VEGFA, IFNG
14positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.5PTGS2, VEGFA
15positive regulation of nitric oxide biosynthetic processGO:0454299.3PTGS2, IFNG
16G-protein coupled receptor signaling pathwayGO:0071869.1RHO, CXCL12, CXCL10
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.8VEGFA, CXCL10, IFNG, IL10
18inflammatory responseGO:0069548.7PTGS2, CXCL10, IL10
19response to drugGO:0424938.5IL10, IFNG, PTGS2

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL12, CXCL10
2growth factor activityGO:0080839.0IL10, CXCL12, VEGFA
3cytokine activityGO:0051258.6IL10, IFNG, VEGFA

Products for genes affiliated with Cystoid Macular Edema

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Sources for Cystoid Macular Edema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet