MCID: CYS006
MIFTS: 50

Cystoid Macular Edema malady

Summaries for Cystoid Macular Edema

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46OMIM, 32MalaCards
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MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to retinitis and macular retinal edema. An important gene associated with Cystoid Macular Edema is PDE6G (phosphodiesterase 6G, cGMP-specific, rod, gamma), and among its related pathways are Visual phototransduction and Visual signal transduction- Rods. The drugs flurbiprofen and flurbiprofen sodium and the compounds rolipram and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are no phenotypic analysis and nervous system.

Description from OMIM:46 153880

Aliases & Classifications for Cystoid Macular Edema

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH
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Aliases & Descriptions:

cystoid macular edema 8 10
macular edema, cystoid 60


External Ids:

Disease Ontology8 DOID:4447
NCIt39 C34794
SNOMED-CT56 193387007
OMIM46 153880
MeSH34 D008269

Related Diseases for Cystoid Macular Edema

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17GeneCards, 18GeneDecks
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Diseases related to Cystoid Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.7RHO
2macular retinal edema31.7CXCL12, VEGFA
3uveitis31.4IFNG, HLA-B, RHO, CXCL10, IL10
4retinal vein occlusion31.3VEGFA
5retinal detachment31.0VEGFA
6glaucoma30.8TTF2
7diabetic retinopathy30.7CXCL12, VEGFA, RHO
8melanoma30.6IFNG, HLA-B, RHO, VEGFA, CXCL10, IL10
9retinopathy of prematurity30.5VEGFA
10acquired immunodeficiency syndrome30.5HLA-B, CXCL12
11vasculitis30.3HLA-B
12keratitis30.3VEGFA
13endophthalmitis30.3VEGFA
14adenoma30.3PTGS2, HLA-B
15hepatitis30.3TTF2, CXCL12, CXCL10, HLA-B
16hepatitis c30.3IFNG, CXCL10, IL10
17multiple sclerosis30.3IFNG, HLA-B, CXCL10, CXCL12, IL10
18cataract11.0
19retinitis pigmentosa10.9
20diabetic macular edema10.9
21choroiditis10.7
22central retinal vein occlusion10.7
23macular holes10.6
24corneal edema10.5
25gyrate atrophy10.4
26ocular hypertension10.4
27poems syndrome10.4
28posterior uveitis10.4
29hypertension10.4
30intermediate uveitis10.4
31neuropathy10.4
32ocular hypotension10.4
33papilledema10.4
34cystoid macular dystrophy10.4
35age related macular degeneration10.2
36central retinal artery occlusion10.2
37crohn's disease10.2
38iritis10.2
39cycloplegia10.2
40danon disease10.2
41bullous keratopathy10.2
42ischemic neuropathy10.2
43coats disease10.2
44lyme disease10.2
45retinal melanoma10.2
46macular keratitis10.2
47preretinal fibrosis10.2
48churg-strauss syndrome10.2
49vitelliform macular dystrophy10.2
50ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Clinical Features for Cystoid Macular Edema

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46OMIM
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Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cystoid Macular Edema

Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Search CenterWatch for Cystoid Macular Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cystoid Macular Edema

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Anatomical Context for Cystoid Macular Edema

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32MalaCards
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MalaCards organs/tissues related to Cystoid Macular Edema:

32
Eye, Retina, Endothelial, Bone, Bone marrow, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Cystoid Macular Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9PTGS2, RHO
2MP:00036319.8RHO, PDE6A, PDE6G
3MP:00053919.7PDE6G, PDE6A, RHO
4MP:00053708.4PTGS2, IL10, CXCL12, VEGFA, IFNG
5MP:00053857.7IFNG, RHO, VEGFA, CXCL10, CXCL12, IL10
6MP:00053977.2IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
7MP:00053846.9IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
8MP:00053876.8IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12

Publications for Cystoid Macular Edema

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50PubMed
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Articles related to Cystoid Macular Edema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Phakic cystoid macular edema secondary to idiopathic macular telangiectasia type 1 responsive to topical anti-inflammatory agents. (23448562)
2013
2
Cystoid macular edema in retinitis pigmentosa patients without associated macular thickening. (23448561)
2013
3
Pseudophakic cystoid macular edema. (21921587)
2012
4
Intravitreal bevacizumab for pseudophakic cystoid macular edema. (22034022)
2012
5
Intravitreal bevacizumab for pseudophakic cystoid macular edema; a systematic review. (23264866)
2012
6
Cystoid macular edema induced by nab-paclitaxel. (22592399)
2012
7
Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurity. (22232366)
2012
8
Optical coherence tomographic reflectivity of photoreceptors beneath cystoid spaces in diabetic macular edema. (22323463)
2012
9
Cystoid Macular Edema after Complicated Cataract Surgery Resolved by an Intravitreal Dexamethasone 0.7-mg Implant. (22125533)
2011
10
Full Thickness Macular Hole Formation in a Patient with Cystoid Macular Edema Caused by CRVO Treated with Intravitreal Bevacizicumab. (20337340)
2010
11
Cystoid macular edema without macular thickening: a retrospective optical coherence tomographic study. (20168270)
2010
12
Bilateral and simultaneous cystoid macular edema associated with latanoprost use: report of two cases. (20549052)
2010
13
Cystoid macular edema secondary to immune recovery uveitis in a man with cytomegalovirus retinitis and AIDS. (20957141)
2010
14
Pseudophakic cystoid macular edema. (20057303)
2010
15
Postsurgical cystoid macular edema. (20703048)
2010
16
Bevacizumab compared with macular laser grid photocoagulation for cystoid macular edema in branch retinal vein occlusion. (20827152)
2010
17
Serous detachment of macula in cystoid macular edema associated with latanoprost. (18988179)
2008
18
Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient. (18195237)
2008
19
Effect of prophylactic nonsteroidal antiinflammatory drugs on cystoid macular edema assessed using optical coherence tomography quantification of total macular volume after cataract surgery. (18165083)
2008
20
Intravitreal vs. subtenon triamcinolone acetonide for the treatment of diabetic cystoid macular edema. (18366650)
2008
21
Efficacy and complications of intravitreal injection of triamcinolone acetonide for refractory cystoid macular edema associated with intraocular inflammation. (18991038)
2008
22
Cystoid macular edema. (19668445)
2008
23
Foveal photoreceptor layer in eyes with persistent cystoid macular edema associated with branch retinal vein occlusion. (18045566)
2008
24
25-gauge vitrectomy and triamcinolone acetonide-assisted internal limiting membrane peeling for chronic cystoid macular edema associated with branch retinal vein occlusion. (18698296)
2008
25
Cystoid macular edema in a pseudophakic patient after switching from latanoprost to BAK-free travoprost. (18001244)
2007
26
The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. (16597536)
2006
27
Surgical removal of the internal limiting membrane in diabetic cystoid macular edema. (16603977)
2006
28
Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema. (16815285)
2006
29
Cystoid macular edema from niacin typically is not accompanied by fluorescein leakage on angiography. (15860328)
2005
30
Early treatment of cystoid macular edema secondary to branch retinal vein occlusion with intravitreal triamcinolone acetonide. (15688969)
2005
31
Pseudophakic cystoid macular edema: ketorolac alone vs. ketorolac plus prednisolone. (15180141)
2004
32
Treatment of cystoid macular edema with oral acetazolamide in a patient with best vitelliform macular dystrophy. (15187682)
2004
33
Managing cystoid macular edema after cataract surgery. (12544809)
2003
34
Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study. (11297495)
2001
35
Ketorolac treatment of pseudophakic cystoid macular edema identified more than 24 months after cataract extraction. (10485530)
1999
36
Human T-cell lymphotrophic virus antibody in phakic cystoid macular edema. (10565535)
1999
37
Cystoid macular edema associated with cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. (9512171)
1998
38
Cystoid macular edema and anterior uveitis associated with latanoprost use. Experience and incidence in a retrospective review of 94 patients. (9479285)
1998
39
Chronic cystoid macular edema and predictors of visual acuity. (8321508)
1993
40
Prediction of visual acuity recovery in cystoid macular edema. (1603539)
1992
41
Treating cystoid macular edema with cycloplegia. (2810102)
1989
42
Cystoid macular edema in keratoplasty. (3327205)
1987
43
Treatment of pseudophakic cystoid macular edema by elevation of intraocular pressure. (6508106)
1984
44
Role of the vitreous in cystoid macular edema. (6463849)
1984
45
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
46
Quick-staining of whole retina for pathological demonstration of cystoid macular edema. (6193034)
1983
47
Cystoid macular edema associated with limbal melanoma. (6667858)
1983
48
Prophylaxis of pseudophakic cystoid macular edema with topical indomethacin. (6752799)
1982
49
Cystoid macular edema after aphakic penetrating keratoplasty. (7033865)
1981
50
Anterior vitrectomy for chronic aphakic cystoid macular edema. (7422258)
1980

Genetic Variations for Cystoid Macular Edema

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Expression for genes affiliated with Cystoid Macular Edema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 12EMD Millipore
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Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6PDE6G, PDE6A, RHO
2
Hide members
9.6PDE6G, PDE6A, RHO
39.6RHO, PDE6A, PDE6G
4
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9.5IL10, IFNG
5
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9.4PTGS2, CXCL12, CXCL10
69.1CXCL10, HLA-B, IFNG
7
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8.6IFNG, HLA-B, CXCL12, IL10
8
Hide members
8.5PTGS2, VEGFA, HLA-B, IFNG

Compounds for genes affiliated with Cystoid Macular Edema

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.3PDE6A, PDE6G
2cycloheximide4410.3CXCL12, CXCL10
3pge24410.1PTGS2, VEGFA
4tacrolimus44 49 1112.1CXCL10, IFNG
52,5-oligoadenylate4410.0HLA-B, CXCL10
6gm-csf44 2810.9IFNG, IL10
7lenalidomide44 1110.9PTGS2, VEGFA
8bucillamine449.9IFNG, VEGFA
9betaseron449.9IFNG, IL10
10(r)-(-)-rolipram599.9PDE6A, PDE6G
11interferon gamma449.9IL10, IFNG
12misoprostol44 1110.9IL10, PTGS2
13groalpha449.8IL10, CXCL12, CXCL10
14alpha-galactosylceramide449.8IL10, IFNG
15dexamethasone44 49 28 1112.8VEGFA, CXCL12, PTGS2
16glatiramer acetate44 1110.7IFNG, IL10
17tuberculin449.7IFNG, IL10
18natalizumab44 1110.7IFNG, IL10
19cobalt chloride449.7IFNG, VEGFA
20il 10449.6IL10, CXCL10, IFNG
21neopterin449.6IL10, CXCL10, IFNG
22allergens449.6IFNG, CXCL10, IL10
23gemcitabine44 49 1111.5VEGFA, IL10, PTGS2
24triptolide449.5IFNG, VEGFA, PTGS2
25etanercept44 49 1111.5IFNG, IL10, PTGS2
26mdms449.4IL10, CXCL12
27rantes449.4IFNG, HLA-B, CXCL12
28tarc449.4IFNG, CXCL10, CXCL12, IL10
29ccl344 2810.4IFNG, CXCL10, CXCL12, IL10
30ifn-alpha449.4IFNG, CXCL10, CXCL12, IL10
31infliximab44 49 1111.3IFNG, VEGFA, CXCL10, IL10
32prostacyclin449.3RHO, VEGFA, IL10, PTGS2
33histamine44 28 2411.3IL10, CXCL10, RHO, IFNG
34cyclosporin a44 28 5911.3IFNG, HLA-B, TTF2
35simvastatin44 49 59 28 11 2414.2IL10, VEGFA, IFNG
36triamcinolone44 49 28 1112.2PTGS2, CXCL12, VEGFA, IFNG
37gtp44 2810.2TTF2, CXCL12, RHO, HLA-B
38herbimycin a44 5910.2IFNG, CXCL12, PTGS2
39rapamycin449.1IFNG, VEGFA, CXCL12, IL10
4015-deoxy-delta-12,14-prostaglandin j2449.1PTGS2, IL10, VEGFA, IFNG
41thalidomide44 49 59 1112.1PTGS2, IL10, VEGFA, IFNG
42polyinosinic-polycytidylic acid449.1IFNG, HLA-B, CXCL10, IL10
43ribavirin44 49 1111.1IL10, CXCL10, HLA-B, IFNG
44actinomycin d449.1IFNG, VEGFA, CXCL12, PTGS2
45ly294002449.0PTGS2, IL10, CXCL12, VEGFA, RHO
46genistein44 28 59 2 11 2413.9IFNG, VEGFA, CXCL10, CXCL12, PTGS2
47thymidine44 249.8IL10, CXCL12, CXCL10, IFNG
48sb 20358044 599.8IFNG, VEGFA, CXCL12, IL10, PTGS2
49nitric oxide44 11 2410.3IFNG, HLA-B, CXCL10, IL10, TTF2, PTGS2
50vegf448.0IFNG, RHO, VEGFA, CXCL10, CXCL12, IL10

GO Terms for genes affiliated with Cystoid Macular Edema

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16Gene Ontology
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Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.3RHO, PDE6A, PDE6G
2extracellular spaceGO:0056158.6IL10, CXCL12, CXCL10, VEGFA, IFNG

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:0224009.8RHO, PDE6A, PDE6G
2positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.8PTGS2, VEGFA
3induction of positive chemotaxisGO:0509309.8CXCL12, VEGFA
4rhodopsin mediated signaling pathwayGO:0160569.7RHO, PDE6A, PDE6G
5response to vitamin DGO:0332809.7CXCL10, PTGS2
6positive regulation of MHC class II biosynthetic processGO:0453489.6IFNG, IL10
7phototransduction, visible lightGO:0076039.6RHO, PDE6A, PDE6G
8negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-GMP phosphodiesterase activityGO:0475559.8PDE6A, PDE6G
2cytokine activityGO:0051259.2IL10, VEGFA, IFNG
3growth factor activityGO:0080839.0IL10, CXCL12, VEGFA

Products for genes affiliated with Cystoid Macular Edema

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Sources for Cystoid Macular Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet