MCID: CYS006
MIFTS: 54

Cystoid Macular Edema malady

Eye diseases category
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Summaries for Cystoid Macular Edema

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MalaCards based summary: Cystoid Macular Edema, also known as macular edema, cystoid, is related to uveitis and endophthalmitis. An important gene associated with Cystoid Macular Edema is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are The phototransduction cascade and Type II interferon signaling (IFNG). The drugs flurbiprofen and flurbiprofen sodium and the compounds bucillamine and betaseron have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Description from OMIM:46 153880

Aliases & Classifications for Cystoid Macular Edema

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Cystoid Macular Edema, Aliases & Descriptions:

Name: Cystoid Macular Edema 8 10
 
Macular Edema, Cystoid 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:4447
NCIt39 C34794
SNOMED-CT57 193387007
MeSH34 D008269
OMIM46 153880

Related Diseases for Cystoid Macular Edema

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Diseases related to Cystoid Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis31.2CXCL10, IFNG, IL10, RHO
2endophthalmitis31.0VEGFA
3diabetic retinopathy31.0RHO, CXCL12, VEGFA
4age related macular degeneration30.7VEGFA, RHO
5hepatitis30.6TTF2, CXCL10, CXCL12
6hepatitis c30.2IL10, IFNG, CXCL10
7multiple sclerosis30.0CXCL10, CXCL12, IFNG, IL10
8melanoma29.8VEGFA, TTF2, CXCL10, IFNG, IL10, RHO
9arthritis29.7TTF2, PTGS2, CXCL10, IFNG, IL10
10retinitis11.2
11cataract11.1
12retinitis pigmentosa11.0
13retinal vein occlusion10.9
14choroiditis10.8
15retinal detachment10.8
16central retinal vein occlusion10.8
17cytomegalovirus retinitis10.7
18macular holes10.6
19endotheliitis10.6
20hypertension10.4
21poems syndrome10.4
22gyrate atrophy10.4
23acquired immunodeficiency syndrome10.4
24retinopathy of prematurity10.4
25ocular hypertension10.4
26intermediate uveitis10.4
27neuropathy10.4
28ocular hypotension10.4
29papilledema10.4
30cystoid macular dystrophy10.4
31pleurisy10.4PTGS2
32intraocular lymphoma10.4IL10
33meningitis10.4CXCL10
34corneal neovascularization10.3VEGFA, CXCL10
35crohn's disease10.3
36hemangioma10.3
37ischemic optic neuropathy10.3
38keratopathy10.3
39multiple myeloma10.3
40coats disease10.3
41preretinal fibrosis10.3
42iritis10.3
43optic disk drusen10.3
44werner syndrome10.3
45central retinal artery occlusion10.3
46lyme disease10.3
47cycloplegia10.3
48danon disease10.3
49vitelliform macular dystrophy10.3
50churg-strauss syndrome10.3

Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Symptoms for Cystoid Macular Edema

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Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

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Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Cystoid Macular Edema

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Anatomical Context for Cystoid Macular Edema

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MalaCards organs/tissues related to Cystoid Macular Edema:

32
Eye, Retina, Endothelial, Bone marrow, Bone, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

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Publications for Cystoid Macular Edema

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Articles related to Cystoid Macular Edema:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Treatment and functional outcome of patients with cystoid macular edema: a single-center experience. (25028250)
2014
2
Intravitreal injection of dexamethasone implant and ranibizumab in cystoid macular edema in the course of irvine-gass syndrome. (25232337)
2014
3
Intravitreal diclofenac for refractory uveitic cystoid macular edema. (23825712)
2013
4
Phakic cystoid macular edema secondary to idiopathic macular telangiectasia type 1 responsive to topical anti-inflammatory agents. (23448562)
2013
5
INTRAVITREAL DICLOFENAC VERSUS INTRAVITREAL TRIAMCINOLONE FOR THE TREATMENT OF UVEITIC CYSTOID MACULAR EDEMA. (23584700)
2013
6
Subtenon triamcinolone injection for postoperative cystoid macular edema associated with tafluprost. (23901262)
2013
7
Cystoid macular edema secondary to nanoparticle albumin-bound Paclitaxel therapy. (23421925)
2013
8
Selective laser trabeculoplasty complicated by cystoid macular edema: report of two cases. (23225841)
2012
9
Incidence of acute postoperative cystoid macular edema in clinical practice. (23084360)
2012
10
Intravitreal triamcinolone acetonide versus pars plana vitrectomy for pseudophakic cystoid macular edema. (22928501)
2012
11
A case of cystoid macular edema associated with Paclitaxel chemotherapy. (23060727)
2012
12
Efficacy and safety of intravitreal bevacizumab compared with intravitreal and posterior sub-tenon triamcinolone acetonide for treatment of uveitic cystoid macular edema. (20856170)
2011
13
Comparison of serum glycosylated hemoglobin levels in patients with diabetic cystoid macular edema with and without serous macular detachment. (20689191)
2010
14
Cystoid macular edema in uveitis. (20703047)
2010
15
Intravitreal bevacizumab versus triamcinolone acetonide for refractory uveitic cystoid macular edema: a randomized pilot study. (20307215)
2010
16
Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone. (23861610)
2010
17
Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema. (19482498)
2009
18
Serous detachment of macula in cystoid macular edema associated with latanoprost. (18988179)
2008
19
Corneal melting after use of nepafenac in a patient with chronic cystoid macular edema after cataract surgery. (18327052)
2008
20
The effect of topical diclofenac on choroidal blood flow in early postoperative pseudophakias with regard to cystoid macular edema formation. (18055815)
2007
21
Primary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema: pilot study of the Pan-American Collaborative Retina Study Group. (18053911)
2007
22
The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. (16597536)
2006
23
Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. (16546110)
2006
24
Optical coherence tomography and focal electroretinogram evaluation of cystoid macular edema secondary to retinitis pigmentosa treated with intravitreal triamcinolone: case report. (17191201)
2006
25
A case of POEMS syndrome with cystoid macular edema. (15767082)
2005
26
Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. (16086944)
2005
27
Pathomechanisms of cystoid macular edema. (15583429)
2004
28
Retinal vasculitis and cystoid macular edema after body tattooing: a case report. (15162298)
2004
29
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide: case report. (15180250)
2003
30
Managing cystoid macular edema after cataract surgery. (12544809)
2003
31
Treatment of cystoid macular edema related to retinitis pigmentosa with intravitreal triamcinolone acetonide. (14509465)
2003
32
Pars plana vitrectomy for cystoid macular edema secondary to sarcoid uveitis. (11382643)
2001
33
Interferon-associated retinopathy and cystoid macular edema. (11448335)
2001
34
Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study. (11297495)
2001
35
Cystoid macular edema in patients with acquired immune deficiency syndrome and cytomegalovirus retinitis. (11071031)
2000
36
Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. (10541898)
1999
37
Phakic patients with cystoid macular edema, retinal periphlebitis, and vitreous inflammation. (9715682)
1998
38
Bilateral cystoid macular edema in a 21-year-old woman. (8779089)
1996
39
Pathophysiology and treatment of cystoid macular edema. (8913630)
1996
40
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994
41
Cystoid macular edema. (3420664)
1988
42
Natural course of nonaphakic cystoid macular edema. (6463848)
1984
43
The national, prospective, randomized vitrectomy study for chronic aphakic cystoid macular edema. Progress report and comparison between the control and nonrandomized groups. (6463852)
1984
44
Corneal endothelial cell loss, cystoid macular edema, and iris-supported intraocular lenses. (6472820)
1984
45
Annotated bibliography: cystoid macular edema. (6379954)
1984
46
Pathology of human cystoid macular edema. (6463850)
1984
47
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
48
YAG laser treatment of cystoid macular edema. (6688505)
1983
49
Surgical therapy for chronic aphakic cystoid macular edema. (6752800)
1982
50
Cystoid macular edema after retinal detachment surgery. (7243204)
1980

Variations for Cystoid Macular Edema

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Expression for genes affiliated with Cystoid Macular Edema

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Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

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Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8RHO, PDE6A
29.6IFNG, CXCL10
39.4IFNG, VEGFA
49.3IL10, IFNG
59.3IFNG, IL10
6
Show member pathways
IL27-mediated signaling events37
9.3IL10, IFNG
7
Show member pathways
9.3IFNG, IL10
89.3IFNG, IL10
99.3IL10, IFNG
109.3IL10, IFNG
119.2PTGS2, VEGFA
12
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.2PTGS2, VEGFA
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.0IFNG, PTGS2
149.0IFNG, PTGS2
15
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0IL10, IFNG, CXCL10
169.0VEGFA, CXCL12, IFNG
17
Show member pathways
8.9CXCL12, IFNG, IL10
18
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.9RHO, PTGS2, VEGFA
19
Show member pathways
8.6VEGFA, CXCL10, CXCL12, PDE6A, RHO
20
Show member pathways
8.5IL10, IFNG, PTGS2
21
Show member pathways
8.4PTGS2, CXCL10, CXCL12, IL10
22
Show member pathways
7.3IL10, IFNG, CXCL12, CXCL10, PTGS2, VEGFA

Compounds for genes affiliated with Cystoid Macular Edema

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Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1bucillamine449.7IFNG, VEGFA
2betaseron449.7IL10, IFNG
3groalpha449.7CXCL10, CXCL12, IL10
4interferon gamma449.6IL10, IFNG
5alpha-galactosylceramide449.6IL10, IFNG
62,5-oligoadenylate449.4CXCL10, IFNG, IL10
7polyinosinic-polycytidylic acid449.4CXCL10, IFNG, IL10
8lenalidomide44 1110.4PTGS2, VEGFA
9il 10449.4CXCL10, IFNG, IL10
10ribavirin44 50 1111.4IL10, IFNG, CXCL10
11neopterin449.4IL10, IFNG, CXCL10
12allergens449.4IL10, IFNG, CXCL10
13rolipram44 61 2811.4IFNG, IL10, PDE6A
14misoprostol44 1110.3PTGS2, IL10
15natalizumab44 1110.3IL10, IFNG
16hydrocortisone44 2 61 1112.3CXCL10, IFNG, IL10
17gm-csf44 2810.3VEGFA, IFNG, IL10
18tuberculin449.2IFNG, IL10
19imatinib44 50 1111.2IL10, CXCL12, VEGFA
20heparin44 28 24 1112.2VEGFA, TTF2, CXCL12, RHO
21cyclophosphamide44 50 1111.2VEGFA, CXCL12, IL10
22histamine44 28 2411.1CXCL10, IFNG, IL10, RHO
23tarc449.1CXCL10, CXCL12, IFNG, IL10
24ccl344 2810.1CXCL10, CXCL12, IFNG, IL10
25ifn-alpha449.1CXCL10, CXCL12, IFNG, IL10
26simvastatin44 50 61 28 24 1114.1VEGFA, IFNG, IL10
27endotoxin449.0IL10, IFNG, CXCL10
28glatiramer acetate44 1110.0IFNG, IL10
29infliximab44 50 1111.0VEGFA, CXCL10, IFNG, IL10
30rantes449.0IL10, IFNG, CXCL12, CXCL10
31gemcitabine44 50 1111.0VEGFA, PTGS2, IL10
32triptolide449.0VEGFA, PTGS2, IFNG
33thymidine44 249.9CXCL10, CXCL12, IFNG, IL10
34etanercept44 50 1110.9IL10, IFNG, PTGS2
35rapamycin448.8VEGFA, CXCL12, IFNG, IL10
36herbimycin a44 619.8PTGS2, CXCL12, IFNG
37prostacyclin448.8RHO, IL10, PTGS2, VEGFA
38triamcinolone50 44 28 1111.6VEGFA, PTGS2, CXCL12, IFNG
39actinomycin d448.5VEGFA, PTGS2, CXCL12, IFNG
4015-deoxy-delta-12,14-prostaglandin j2448.5IL10, IFNG, PTGS2, VEGFA
41thalidomide44 50 61 1111.5VEGFA, PTGS2, IFNG, IL10
42estrogen448.5VEGFA, TTF2, PTGS2, CXCL10, CXCL12
43ly294002448.4RHO, IL10, CXCL12, PTGS2, VEGFA
44genistein44 28 61 2 24 1113.3VEGFA, PTGS2, CXCL10, CXCL12, IFNG
45nitric oxide44 24 1110.2TTF2, PTGS2, CXCL10, IFNG, IL10
46sb 20358044 619.1VEGFA, PTGS2, CXCL12, IFNG, IL10
47pge2447.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
48cycloheximide447.8VEGFA, PTGS2, CXCL10, CXCL12, IFNG, IL10
49dexamethasone44 50 28 1110.4VEGFA, TTF2, PTGS2, CXCL10, CXCL12, IFNG
50vegf447.1RHO, VEGFA, TTF2, PTGS2, CXCL10, CXCL12

GO Terms for genes affiliated with Cystoid Macular Edema

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Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.5PDE6A, RHO
2external side of plasma membraneGO:0098979.1IFNG, CXCL12, CXCL10
3extracellular spaceGO:0056158.1IL10, IFNG, CXCL12, CXCL10, VEGFA

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1chemokine-mediated signaling pathwayGO:07009810.0CXCL12, CXCL10
2regulation of rhodopsin mediated signaling pathwayGO:02240010.0PDE6A, RHO
3rhodopsin mediated signaling pathwayGO:01605610.0RHO, PDE6A
4positive regulation of axon extension involved in axon guidanceGO:0488429.9CXCL12, VEGFA
5induction of positive chemotaxisGO:0509309.9VEGFA, CXCL12
6blood circulationGO:0080159.8CXCL10, CXCL12
7retina development in camera-type eyeGO:0600419.8RHO, PDE6A
8patterning of blood vesselsGO:0015699.7VEGFA, CXCL12
9positive regulation of MHC class II biosynthetic processGO:0453489.7IL10, IFNG
10response to vitamin DGO:0332809.6PTGS2, CXCL10
11negative regulation of growth of symbiont in hostGO:0441309.6IFNG, IL10
12positive regulation of cell adhesionGO:0457859.6VEGFA, IFNG
13positive regulation of mesenchymal cell proliferationGO:0020539.5VEGFA, IFNG
14positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.5PTGS2, VEGFA
15positive regulation of nitric oxide biosynthetic processGO:0454299.3PTGS2, IFNG
16G-protein coupled receptor signaling pathwayGO:0071869.1RHO, CXCL12, CXCL10
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.8VEGFA, CXCL10, IFNG, IL10
18inflammatory responseGO:0069548.7PTGS2, CXCL10, IL10
19response to drugGO:0424938.5IL10, IFNG, PTGS2

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8CXCL12, CXCL10
2growth factor activityGO:0080839.0IL10, CXCL12, VEGFA
3cytokine activityGO:0051258.6IL10, IFNG, VEGFA

Products for genes affiliated with Cystoid Macular Edema

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Sources for Cystoid Macular Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet