MCID: CYS006
MIFTS: 50

Cystoid Macular Edema malady

Summaries for Cystoid Macular Edema

About this section
Sources:
46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Cystoid Macular Edema, also known as macular edema, cystoid, is related to retinitis and macular retinal edema. An important gene associated with Cystoid Macular Edema is PDE6G (phosphodiesterase 6G, cGMP-specific, rod, gamma), and among its related pathways are Visual phototransduction and Visual signal transduction- Rods. The drugs flurbiprofen and flurbiprofen sodium and the compounds rolipram and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are no phenotypic analysis and nervous system.

Description from OMIM:46 153880

Aliases & Classifications for Cystoid Macular Edema

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 46OMIM, 34MeSH
See all sources

Aliases & Descriptions:

cystoid macular edema 8 10
macular edema, cystoid 60


External Ids:

Disease Ontology8 DOID:4447
NCIt39 C34794
SNOMED-CT56 193387007
OMIM46 153880
MeSH34 D008269

Related Diseases for Cystoid Macular Edema

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Cystoid Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.7RHO
2macular retinal edema31.7CXCL12, VEGFA
3uveitis31.4IFNG, HLA-B, RHO, CXCL10, IL10
4retinal vein occlusion31.3VEGFA
5retinal detachment31.0VEGFA
6glaucoma30.8TTF2
7diabetic retinopathy30.7CXCL12, VEGFA, RHO
8melanoma30.6IFNG, HLA-B, RHO, VEGFA, CXCL10, IL10
9retinopathy of prematurity30.5VEGFA
10acquired immunodeficiency syndrome30.5HLA-B, CXCL12
11vasculitis30.3HLA-B
12keratitis30.3VEGFA
13endophthalmitis30.3VEGFA
14adenoma30.3PTGS2, HLA-B
15hepatitis30.3TTF2, CXCL12, CXCL10, HLA-B
16hepatitis c30.3IFNG, CXCL10, IL10
17multiple sclerosis30.3IFNG, HLA-B, CXCL10, CXCL12, IL10
18cataract11.0
19retinitis pigmentosa10.9
20diabetic macular edema10.9
21choroiditis10.7
22central retinal vein occlusion10.7
23macular holes10.6
24corneal edema10.5
25gyrate atrophy10.4
26ocular hypertension10.4
27poems syndrome10.4
28posterior uveitis10.4
29hypertension10.4
30intermediate uveitis10.4
31neuropathy10.4
32ocular hypotension10.4
33papilledema10.4
34cystoid macular dystrophy10.4
35age related macular degeneration10.2
36central retinal artery occlusion10.2
37crohn's disease10.2
38iritis10.2
39cycloplegia10.2
40danon disease10.2
41bullous keratopathy10.2
42ischemic neuropathy10.2
43coats disease10.2
44lyme disease10.2
45retinal melanoma10.2
46macular keratitis10.2
47preretinal fibrosis10.2
48churg-strauss syndrome10.2
49vitelliform macular dystrophy10.2
50ischemic optic neuropathy10.2

Graphical network of the top 20 diseases related to Cystoid Macular Edema:



Diseases related to cystoid macular edema

Clinical Features for Cystoid Macular Edema

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

153880

Drugs & Therapeutics for Cystoid Macular Edema

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Cystoid Macular Edema

Drug clinical trials:

Search ClinicalTrials for Cystoid Macular Edema

Search NIH Clinical Center for Cystoid Macular Edema

Search CenterWatch for Cystoid Macular Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cystoid Macular Edema

About this section

Anatomical Context for Cystoid Macular Edema

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Cystoid Macular Edema:

32
Eye, Retina, Endothelial, Bone marrow, Bone, Myeloid, T cells

Animal Models for Cystoid Macular Edema or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Cystoid Macular Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.9PTGS2, RHO
2MP:00036319.8RHO, PDE6A, PDE6G
3MP:00053919.7PDE6G, PDE6A, RHO
4MP:00053708.4PTGS2, IL10, CXCL12, VEGFA, IFNG
5MP:00053857.7IFNG, RHO, VEGFA, CXCL10, CXCL12, IL10
6MP:00053977.2IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
7MP:00053846.9IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12
8MP:00053876.8IFNG, HLA-B, RHO, VEGFA, CXCL10, CXCL12

Publications for Cystoid Macular Edema

About this section
Sources:
50PubMed
See all sources

Articles related to Cystoid Macular Edema:

(show top 50)    (show all 498)
idTitleAuthorsYear
1
Correlations between spectral-domain OCT measurements and visual acuity in cystoid macular edema associated with retinitis pigmentosa. (23329664)
2013
2
Morphologic and functional evaluations during development, resolution, and relapse of uveitis-associated cystoid macular edema. (23584695)
2013
3
Bilateral cystoid macular edema in a patient with taxane-based chemotherapy. (23419309)
2013
4
Cystoid macular edema associated with fingolimod use for multiple sclerosis. (23307220)
2013
5
Longstanding refractory pseudophakic cystoid macular edema resolved using intravitreal 0.7 mg dexamethasone implants. (23818753)
2013
6
Error in Figure 4F in: Spectral-Domain Optical Coherence Tomographic Assessment of Severity of Cystoid Macular Edema in Retinopathy of Prematurity. (23753941)
2012
7
Intravitreal ranibizumab for the treatment of cystoid macular edema in Irvine-Gass syndrome. (22731243)
2012
8
Interferon alpha 2b in the treatment of uveitic cystoid macular edema. (22409560)
2012
9
Efficacy and safety of intravitreal bevacizumab compared with intravitreal and posterior sub-tenon triamcinolone acetonide for treatment of uveitic cystoid macular edema. (20856170)
2011
10
Use of intraocular ketorolac tromethamine for the treatment of chronic cystoid macular edema. (20648080)
2010
11
Correlation between fluorescein angiography and spectral-domain optical coherence tomography in the diagnosis of cystoid macular edema. (19965832)
2010
12
Cystoid Macular Edema: Possible Complication of Infliximab Therapy in BehAset's Disease. (20737054)
2010
13
Intravitreal bevacizumab for refractory pseudophakic cystoid macular edema: the Pan-American Collaborative Retina Study Group results. (19545901)
2009
14
Intravitreal ranibizumab in the treatment of cystoid macular edema associated with retinitis pigmentosa. (20028262)
2009
15
USE OF CORONAL SIMULTANEOUS OPTICAL COHERENCE TOMOGRAPHY/SCANNING LASER OPHTHALMOSCOPY TO DEMONSTRATE CYSTOID MACULAR EDEMA SECONDARY TO EXTRAFOVEAL RETINAL HOLE. (19759837)
2008
16
Successful treatment of cystoid macular edema with valdecoxib. (17397743)
2007
17
Cystoid macular edema following photorefractive keratectomy complicated by presumptive infectious keratitis. (17276286)
2007
18
Effect of oral pentoxifylline on cystoid macular edema associated with central retinal vein occlusion. (18040238)
2007
19
Optic disc edema, cystoid macular edema, and elevated vascular endothelial growth factor in a patient with POEMS syndrome. (17895817)
2007
20
Optical coherence tomography and focal electroretinogram evaluation of cystoid macular edema secondary to retinitis pigmentosa treated with intravitreal triamcinolone: case report. (17191201)
2006
21
Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema. (16508440)
2006
22
Incidence of cystoid macular edema after uncomplicated phacoemulsification. (14573973)
2003
23
Intravitreal triamcinolone acetonide for pseudophakic cystoid macular edema. (12888077)
2003
24
Cystoid macular edema in aphakia and pseudophakia after use of prostaglandin analogs. (12759848)
2002
25
Pars plana vitrectomy for cystoid macular edema secondary to sarcoid uveitis. (11382643)
2001
26
Interferon-associated retinopathy and cystoid macular edema. (11448335)
2001
27
Pars-plana vitrectomy in cystoid macular edema associated with intermediate uveitis. (11521690)
2001
28
Ketorolac versus prednisolone versus combination therapy in the treatment of acute pseudophakic cystoid macular edema. (11054327)
2000
29
Pseudophakic cystoid macular edema treated with high-dose intravenous methylprednisolone. (10476516)
1999
30
Cystoid macular edema associated with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension. (10328408)
1999
31
Treatment of cystoid macular edema with octreotide. (9480445)
1998
32
Posterior sub-Tenon injections of repository corticosteroids in uveitis patients with cystoid macular edema. (7643487)
1995
33
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994
34
Recurrent uveitis, cystoid macular edema and pericarditis in Lyme disease. (22823081)
1994
35
Treatment of cystoid macular edema with acetazolamide in a patient with serpiginous choroidopathy. (1813958)
1991
36
Intraocular lens removal for chronic cystoid macular edema. (2778692)
1989
37
Effect of a pupillary light occluder on cystoid macular edema. (2614709)
1989
38
Cystoid macular edema. (3420664)
1988
39
Pseudophakic cystoid macular edema: a revised comparison of the incidence with intracapsular and extracapsular cataract extraction. (3347455)
1988
40
Light-induced maculopathy and cystoid macular edema. (3339555)
1988
41
Idiopathic preretinal fibrosis with concurrent cystoid macular edema. (3429756)
1987
42
Macular thickening and visual acuity. Measurement in patients with cystoid macular edema. (3684231)
1987
43
Pharmacologic therapy of aphakic and pseudophakic cystoid macular edema. 1985 update. (3897936)
1985
44
A clinical, fluorescein angiographic, and electron microscopic correlation of cystoid macular edema. (4014384)
1985
45
Effect of retrobulbar hyaluronidase on pseudophakic cystoid macular edema. (6874539)
1983
46
Clinical cystoid macular edema with intracapsular cataract extraction and posterior chamber lens implantation. (6571347)
1983
47
A fluorescein angiographic study of cystoid macular edema. (7315927)
1981
48
Aphakic cystoid macular edema in children. (7469860)
1981
49
Pathology and pathogenesis of cystoid macular edema. (7312293)
1981
50
Clinical factors relating to cystoid macular edema after lens implantation. (7228802)
1981

Genetic Variations for Cystoid Macular Edema

About this section

Expression for genes affiliated with Cystoid Macular Edema

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Cystoid Macular Edema

Search GEO for disease gene expression data for Cystoid Macular Edema.

Pathways for genes affiliated with Cystoid Macular Edema

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6PDE6G, PDE6A, RHO
2
Hide members
9.6PDE6G, PDE6A, RHO
39.6RHO, PDE6A, PDE6G
4
Hide members
9.5IL10, IFNG
5
Hide members
9.4PTGS2, CXCL12, CXCL10
69.1CXCL10, HLA-B, IFNG
7
Hide members
8.6IFNG, HLA-B, CXCL12, IL10
8
Hide members
8.5PTGS2, VEGFA, HLA-B, IFNG

Compounds for genes affiliated with Cystoid Macular Edema

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rolipram44 59 2812.3PDE6G, PDE6A
2cycloheximide4410.3CXCL12, CXCL10
3pge24410.1VEGFA, PTGS2
4tacrolimus44 49 1112.1CXCL10, IFNG
52,5-oligoadenylate4410.0CXCL10, HLA-B
6gm-csf44 2810.9IL10, IFNG
7lenalidomide44 1110.9VEGFA, PTGS2
8bucillamine449.9VEGFA, IFNG
9betaseron449.9IL10, IFNG
10interferon gamma449.9IL10, IFNG
11misoprostol44 1110.9PTGS2, IL10
12groalpha449.8CXCL10, IL10, CXCL12
13alpha-galactosylceramide449.8IFNG, IL10
14dexamethasone44 49 28 1112.8VEGFA, CXCL12, PTGS2
15glatiramer acetate44 1110.7IFNG, IL10
16tuberculin449.7IFNG, IL10
17cobalt chloride449.7VEGFA, IFNG
18natalizumab44 1110.7IL10, IFNG
19il 10449.6CXCL10, IFNG, IL10
20neopterin449.6CXCL10, IFNG, IL10
21allergens449.6IFNG, CXCL10, IL10
22clodronate44 49 1111.6IL10, PTGS2
23gemcitabine44 49 1111.5IL10, VEGFA, PTGS2
24triptolide449.5VEGFA, IFNG, PTGS2
25etanercept44 49 1111.5IL10, IFNG, PTGS2
26mdms449.4CXCL12, IL10
27rantes449.4CXCL12, HLA-B, IFNG
28tarc449.4IL10, CXCL12, CXCL10, IFNG
29ccl344 2810.4CXCL10, CXCL12, IL10, IFNG
30ifn-alpha449.4IFNG, CXCL10, IL10, CXCL12
31infliximab44 49 1111.3IFNG, IL10, VEGFA, CXCL10
32prostacyclin449.3PTGS2, IL10, VEGFA, RHO
33histamine44 28 2411.3IFNG, RHO, CXCL10, IL10
34cyclosporin a44 28 5911.3HLA-B, IFNG, TTF2
35simvastatin44 49 59 28 11 2414.2IFNG, VEGFA, IL10
36triamcinolone44 49 28 1112.2PTGS2, CXCL12, VEGFA, IFNG
37gtp44 2810.2HLA-B, RHO, TTF2, CXCL12
38herbimycin a44 5910.2IFNG, PTGS2, CXCL12
39rapamycin449.1IFNG, IL10, CXCL12, VEGFA
4015-deoxy-delta-12,14-prostaglandin j2449.1IFNG, VEGFA, IL10, PTGS2
41thalidomide44 49 59 1112.1IFNG, VEGFA, IL10, PTGS2
42polyinosinic-polycytidylic acid449.1IFNG, IL10, CXCL10, HLA-B
43ribavirin44 49 1111.1HLA-B, IFNG, IL10, CXCL10
44actinomycin d449.1VEGFA, IFNG, PTGS2, CXCL12
45ly294002449.0PTGS2, IL10, CXCL12, VEGFA, RHO
46genistein44 28 59 2 11 2413.9PTGS2, IFNG, VEGFA, CXCL10, CXCL12
47thymidine44 249.8IFNG, CXCL10, CXCL12, IL10
48sb 20358044 599.8PTGS2, IL10, CXCL12, VEGFA, IFNG
49nitric oxide44 11 2410.3TTF2, IL10, CXCL10, HLA-B, IFNG, PTGS2
50vegf448.0IFNG, TTF2, IL10, CXCL12, CXCL10, VEGFA

GO Terms for genes affiliated with Cystoid Macular Edema

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:0973819.3RHO, PDE6A, PDE6G
2extracellular spaceGO:0056158.6IL10, CXCL12, CXCL10, VEGFA, IFNG

Biological processes related to Cystoid Macular Edema according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:0224009.8RHO, PDE6A, PDE6G
2positive regulation of cell migration involved in sprouting angiogenesisGO:0900509.8PTGS2, VEGFA
3induction of positive chemotaxisGO:0509309.8CXCL12, VEGFA
4rhodopsin mediated signaling pathwayGO:0160569.7RHO, PDE6A, PDE6G
5response to vitamin DGO:0332809.7CXCL10, PTGS2
6positive regulation of MHC class II biosynthetic processGO:0453489.6IFNG, IL10
7phototransduction, visible lightGO:0076039.6RHO, PDE6A, PDE6G
8negative regulation of growth of symbiont in hostGO:0441309.2IL10, IFNG

Molecular functions related to Cystoid Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-GMP phosphodiesterase activityGO:0475559.8PDE6A, PDE6G
2cytokine activityGO:0051259.2IL10, VEGFA, IFNG
3growth factor activityGO:0080839.0IL10, CXCL12, VEGFA

Products for genes affiliated with Cystoid Macular Edema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cystoid Macular Edema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet