MCID: CYT008
MIFTS: 50

Cytomegalovirus Infection malady

Summaries for Cytomegalovirus Infection

Sources:
34MedlinePlus, 3CDC, 44NINDS, 33MalaCards
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MedlinePlus:34 Cytomegalovirus (cmv) is a virus found around the world. it is related to the viruses that cause chickenpox and infectious mononucleosis (mono). between 50 percent and 80 percent of adults in the united states have had a cmv infection by age 40. once cmv is in a person's body, it stays there for life. cmv is spread through close contact with body fluids. most people with cmv don't get sick and don't know that they've been infected. but infection with the virus can be serious in babies and people with weak immune systems. if a woman gets cmv when she is pregnant, she can pass it on to her baby. usually the babies do not have health problems. but some babies can develop lifelong disabilities. a blood test can tell whether a person has ever been infected with cmv. most people with cmv don't need treatment. if you have a weakened immune system, your doctor may prescribe antiviral medicine. good hygiene, including proper hand washing, may help prevent infections. centers for disease control and prevention

MalaCards: Cytomegalovirus Infection, also known as cytomegalovirus infections, is related to congenital cytomegalovirus and ulcerative colitis. An important gene associated with Cytomegalovirus Infection is RAG1 (recombination activating gene 1), and among its related pathways are Immune response Fc epsilon RI pathway and Glycosphingolipid biosynthesis - lacto and neolacto series. The drugs immunoglobulins, intravenous and cytomegalovirus immune globulin and the compounds n-acetyllactosamine and gdp fucose have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotype immune system.

CDC:3 Cytomegalovirus (sy toe MEG a low vy rus), or CMV, is a common virus that infects people of all ages. Most CMV infections are "silent," meaning most people who are infected with CMV have no signs or symptoms. However, CMV can cause disease in people with a weakened immune system and in babies infected before birth. About 1 in 150 children is born with congenital (present at birth) CMV infection...more

NINDS:44 Cytomegalovirus (CMV) is a virus found throughout the world that infects between 50 to 80 percent of all adults in the United States by the age of 40.

Aliases & Classifications for Cytomegalovirus Infection

Sources:
44NINDS, 34MedlinePlus, 61UMLS
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Aliases & Descriptions:

cytomegalovirus infection 44
cytomegalovirus infections 34 61


Related Diseases for Cytomegalovirus Infection

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Cytomegalovirus Infection:



Diseases related to cytomegalovirus infection

Clinical Features for Cytomegalovirus Infection

Drugs & Therapeutics for Cytomegalovirus Infection

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Cytomegalovirus Infection

Drug clinical trials:

Search ClinicalTrials for Cytomegalovirus Infection

Search NIH Clinical Center for Cytomegalovirus Infection

Search CenterWatch for Cytomegalovirus Infection

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Cytomegalovirus Infection

Anatomical Context for Cytomegalovirus Infection

Sources:
33MalaCards
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MalaCards organs/tissues related to Cytomegalovirus Infection:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Breast, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Occipital lobe, Hypothalamus, Atrioventricular node, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet

Animal Models for Cytomegalovirus Infection or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Cytomegalovirus Infection:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.1FUT7, TLR12P, IFIT2, NCR1, HOXB4, HOXB7

Publications for Cytomegalovirus Infection

Sources:
51PubMed
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Articles related to Cytomegalovirus Infection:

(show top 50)    (show all 1216)
idTitleAuthorsYear
1
Differential Role for Host Translation Factors in Host and Viral Protein Synthesis during Human Cytomegalovirus Infection. (24198422)
2014
2
Serology indicates cytomegalovirus infection is associated with varicella-zoster virus reactivation. (24037981)
2013
3
Maternal IgG avidity, IgM and ultrasound abnormalities: combined method to detect congenital cytomegalovirus infection with sequelae. (23867961)
2013
4
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection. (23684305)
2013
5
Management of cytomegalovirus infection in haemopoietic stem cell transplantation. (23647436)
2013
6
Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease. (23906542)
2013
7
Congenital cytomegalovirus infection: an obstetrician's point of view. (24257420)
2013
8
Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation. (22160825)
2012
9
Congenital cytomegalovirus infection in fraternal twins: a longitudinal case study examining neurocognitive and neurobehavioral correlates. (23428280)
2012
10
Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients. (23091373)
2012
11
Efficient linking of birth certificate and newborn screening databases for laboratory investigation of congenital cytomegalovirus infection and preterm birth: Florida, 2008. (21203810)
2012
12
UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection. (22723955)
2012
13
Prospective identification of congenital cytomegalovirus infection in newborns using real-time polymerase chain reaction assays in dried blood spots. (21292661)
2011
14
Mixed infection and strain diversity in congenital cytomegalovirus infection. (21881114)
2011
15
Valganciclovir as pre-emptive therapy for cytomegalovirus infection in allogeneic haematopoietic stem cell transplant recipients. (22024510)
2011
16
Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. (22046127)
2011
17
Congenital cytomegalovirus infection and Wiskott-Aldrich syndrome successfully treated with unrelated cord blood transplantation. (21618408)
2011
18
Teaching NeuroImages: CT scan of congenital cytomegalovirus infection. (21242489)
2011
19
Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. (19910789)
2010
20
Monitoring of CD95 and CD38 expression in peripheral blood T lymphocytes during active human cytomegalovirus infection after orthotopic liver transplantation. (19817952)
2010
21
Congenital cytomegalovirus infection associated with severe lung involvement in a preterm neonate: a causal relationship? (19224246)
2009
22
Rehabilitation and outcome of severe profound deafness in a group of 16 infants affected by congenital cytomegalovirus infection. (19283400)
2009
23
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. (19525954)
2009
24
Evaluation of DNA extraction methods for dried blood spots in the diagnosis of congenital cytomegalovirus infection. (19781984)
2009
25
Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred. (19047212)
2008
26
Cutting edge: programmed death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limited hepatitis B virus infection. (18768824)
2008
27
New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. (17542052)
2007
28
AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. (17215282)
2007
29
Comparison of serology assays and polymerase chain reaction for the monitoring of active cytomegalovirus infection in renal transplant recipients. (18021976)
2007
30
Neonatal suppurative parotitis possibly associated with congenital cytomegalovirus infection and maternal methyldopa administration. (16635183)
2006
31
Congenital cytomegalovirus infection and its prevention. (15034840)
2004
32
Birth characteristics and growth pattern in children with congenital cytomegalovirus infection. (14714744)
2003
33
Human cytomegalovirus infection inhibits tumor necrosis factor alpha (TNF-alpha) signaling by targeting the 55-kilodalton TNF-alpha receptor. (12768019)
2003
34
Disseminated cytomegalovirus infection in Crohn's disease following anti-tumour necrosis factor therapy. (12468964)
2002
35
Erythema multiforme associated with cytomegalovirus infection in nonimmunosuppressed patients. (11752816)
2001
36
Prenatal diagnosis of intrauterine cytomegalovirus infection in a fetus with non-immune hydrops fetalis. (11531622)
2001
37
Case 12: obstetrical. Congenital cytomegalovirus infection. (10811423)
2000
38
Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus. (10390260)
1999
39
Infection and replication of human cytomegalovirus in bone marrow stromal cells: effects on the production of IL-6, MIP-1alpha, and TGF-beta1. (9052914)
1997
40
Congenital cytomegalovirus infection in infants infected with human immunodeficiency virus type 1. (8970220)
1996
41
Small intestinal perforation due to cytomegalovirus infection in patients with non-Hodgkin's lymphoma. (7639056)
1995
42
PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection. (8586726)
1995
43
Evidence of active cytomegalovirus infection in clinically stable HIV-infected individuals with CD4+ lymphocyte counts below 100/microliters of blood: features and relation to risk of subsequent CMV retinitis. (7552494)
1995
44
Transient hydrops fetalis associated with intrauterine cytomegalovirus infection: prenatal diagnosis. (9205451)
1994
45
Hydrocephalus ex vacuo and clasp thumb deformity due to congenital cytomegalovirus infection. (7833087)
1994
46
Induction of MHC class I antigen expression following infection of a human esthesioneuroblastoma cell line with cytomegalovirus and human immunodeficiency virus. (1363989)
1992
47
Cyclopia and congenital cytomegalovirus infection. (2823607)
1987
48
Acalculous cholecystitis and cytomegalovirus infection in the acquired immunodeficiency syndrome. (3000250)
1986
49
Central nervous system vasculitis in cytomegalovirus infection. (6268757)
1981
50
Juvenile xanthogranuloma associated with cytomegalovirus infection. (4324278)
1971

Genetic Variations for Cytomegalovirus Infection

Expression for genes affiliated with Cytomegalovirus Infection

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cytomegalovirus Infection

Search GEO for disease gene expression data for Cytomegalovirus Infection.

Pathways for genes affiliated with Cytomegalovirus Infection

Sources:
12EMD Millipore, 30KEGG
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Pathways related to Cytomegalovirus Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9KIR2DS4, KIR2DS2, NCR3, NCR1, KLRAP1, KLRD1
210.6FUT5, FUT7

Compounds for genes affiliated with Cytomegalovirus Infection

Sources:
45Novoseek, 24HMDB
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Compounds related to Cytomegalovirus Infection according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-acetyllactosamine45 2411.6FUT7, KLRB1
2gdp fucose4510.3FUT5, FUT7

GO Terms for genes affiliated with Cytomegalovirus Infection

Sources:
16Gene Ontology
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Biological processes related to Cytomegalovirus Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.7KIR2DS2, LILRB1, KLRD1
2fucosylationGO:03606510.6FUT5, FUT7
3L-fucose catabolic processGO:04235510.5FUT5, FUT7
4anterior/posterior pattern specificationGO:00995210.4HOXB4, HOXC6, HOXB7

Molecular functions related to Cytomegalovirus Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.7KIR2DS2, KLRB1, KLRD1
2alpha-(1->3)-fucosyltransferase activityGO:04692010.5FUT5, FUT7
3fucosyltransferase activityGO:00841710.3FUT5, FUT7

Products for genes affiliated with Cytomegalovirus Infection

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Cytomegalovirus Infection

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet