Cytomegalovirus Infection malady

MedlinePlus: Cytomegalovirus (cmv) is a virus found around the world. it is related to the viruses that cause chickenpox and infectious mononucleosis (mono). between 50 percent and 80 percent of adults in the united states have had a cmv infection by age 40. once cmv is in a person's body, it stays there for life. most people with cmv don't get sick. but infection with the virus can be very serious in babies and people with weak immune systems. if a woman gets cmv when she is pregnant, she can pass it on to her baby. cmv does not harm most babies. but some develop lifelong disabilities. cmv is spread through close contact with body fluids. you should use good hygiene, including proper hand washing, to avoid catching or spreading the virus. most people with cmv don't require treatment. if you have a weakened immune system, your doctor may prescribe antiviral medicine. centers for disease control and prevention²³

MalaCards: Cytomegalovirus Infection, also known as cytomegalovirus infections, is related to congenital cytomegalovirus and hepatitis. An important gene associated with Cytomegalovirus Infection is RAG1 (recombination activating gene 1), and among its related pathways are Immune System and Graft-versus-host disease. The drugs foscarnet and globulin,immune (iv) and the compounds glucose and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and heart, and related mouse phenotypes are respiratory system and hematopoietic system.

CDC: Cytomegalovirus (sy toe MEG a low vy rus), or CMV, is a common virus that infects people of all ages. Most CMV infections are "silent," meaning most people who are infected with CMV have no signs or symptoms. However, CMV can cause disease in people with a weakened immune system and in babies infected before birth. About 1 in 150 children is born with congenital (present at birth) CMV infection...more²

NINDS: Cytomegalovirus (CMV) is a virus found throughout the world that infects between 50 to 80 percent of all adults in the United States by the age of 40. ³¹

cytomegalovirus infection 31 cytomegalovirus infections 23 43

Diseases related to cytomegalovirus infection by text searches and GeneDecks gene sharing:

(show top 50)    (show all 911)

id	Related Disease	Score	Top Affiliating Genes
1	congenital cytomegalovirus	33.4	MT-RNR1, CD40LG, GPT, GJB2, GJB6
2	hepatitis	29.9	SELP, SERPINA1, IL2RB, FAS, GPT, HLA-A
3	autoimmune lymphoproliferative syndrome	29.0	IL10, IL2RA, FAS, CASP8, HDAC9
4	sensorineural hearing loss	28.9	MTHFR, MT-RNR1, APOE, F5, GJB2, GJB6
5	venous thrombosis	28.8	VWF, SELP, MTHFR, F9, F5, F2R
6	hepatitis b	28.5	PDCD1, IL10, IL18, IL2RA, MBL2, CCR5
7	vascular disease	28.5	VWF, SELE, SELP, VCAM1, BMP6, MTHFR
8	lymphoproliferative syndrome	28.4	BCL2, CD40LG, IL10, IL2, IL2RA, FAS
9	adult t-cell leukemia	28.2	NCAM1, BCL2, ITGAL, IL2, IL2RA, IL2RB
10	glioblastoma	28.1	BIRC5, MTOR, CDKN2A, CDKN3, CASP8, HLA-B
11	hearing loss	27.8	MTHFR, MT-RNR1, CDH1, APOE, F5, HSPA4
12	peripheral vascular disease	27.6	VWF, SELE, SELP, VCAM1, MPO, IL18
13	arteriosclerosis	26.7	SELE, SELP, VCAM1, MTHFR, ITGA4, ITGAL
14	t-cell leukemia	26.4	RAG1, BIRC5, BCL2, FUT7, CDK2, CDKN3
15	hepatitis a	25.9	B2M, CD40LG, IL10, IL2, IL2RA, GPT
16	alpha 1-antitrypsin deficiency	25.2	SERPINA1, BMP6, MPO, IL10, IL8, CCL2
17	emphysema	24.8	SERPINA1, BMP6, BLVRB, MPO, CDKN2A, ITGB6
18	immunodeficiency	24.6	PDCD1, KIR3DL1, SELL, BMP6, CFLAR, CD40LG
19	essential hypertension	23.1	VWF, SELE, SELL, SELP, VCAM1, BMP6
20	otitis media	22.9	SELL, VCAM1, BMP6, MPO, CD40LG, ITGAL
21	inflammatory bowel disease	22.5	SELE, SELL, SELP, SERPINA1, VCAM1, MPO
22	leukemia/lymphoma	21.9	PDCD1, VCAM1, RAG1, BCL2, ULBP1, MTHFR
23	abdominal aortic aneurysm	21.3	VWF, SELE, SELL, BMP6, MTHFR, MPO
24	aortic aneurysm	21.0	PIK3C2A, VWF, SELE, SELL, BMP6, MTHFR
25	pertussis	20.6	SELL, BMP6, CD40LG, CD38, ITGA4, ITGA5
26	vasculitis	20.1	PDCD1, VWF, SELE, SELL, SELP, SERPINA1
27	thrombosis	19.8	PIK3C2A, VWF, SELE, SELL, SELP, SERPINA1
28	retinitis	18.4	PIK3C2A, VWF, RBL2, SELE, SELP, SERPINB9
29	neuroblastoma	18.1	NCAM1, KIR3DL1, RBL2, SELP, BMP6, RARA
30	pneumonia	18.0	PIK3C2A, SELE, SELL, SERPINB9, SERPINA1, VCAM1
31	hypertension	16.7	PIK3C2A, NCAM1, VWF, SELE, SELL, SELP
32	leukemia	16.5	PIK3C2A, NCAM1, NCR1, NCR2, NCR3, PDCD1
33	atherosclerosis	16.4	PIK3C2A, PDCD1, VWF, SELE, SELL, SELP
34	ebola hemorrhagic fever	13.9	IFIT2, F5, DDX58, RNPC3
35	tick-borne encephalitis	13.9	B2M, CCL2, CCL3, GPT, IFIT2, DDX58
36	lymphomatoid papulosis	13.9	B2M, FAS, CCR4, CCR3, TRB@, PDGFRA
37	ectopic pregnancy	13.8	PIK3C2A, VCAM1, BMP6, CD40LG, IL2RA, HLA-G
38	erdheim-chester disease	13.7	CCL2, CCR5, CCR3, CCR7
39	mhc class i deficiency	13.7	ULBP1, ULBP2, IFNG, HLA-B, KLRK1
40	glanzmann's thrombasthenia	13.7	VWF, CD9, F9, F2R, THBS1
41	acute interstitial pneumonia	13.7	PIK3C2A, CCR4, CCR7, THBD, TGFB2, CSF3
42	mast-cell leukemia	13.6	MPO, CCL2, CCL3, CCL5
43	peripheral t-cell lymphoma	13.6	NCAM1, IL2RA, IL2RB, CCR4, TRB@, PDGFRA
44	ovarian cancer	13.6	RBL2, CDK2, CDKN2A, CDK7, CDK1, CCNB1
45	immune-complex glomerulonephritis	13.6	SELP, VCAM1, MPO, CD40LG, ITGAL, CCR5
46	arteriosclerosis obliterans	13.6	SELP, VCAM1, ITGA4, ITGAL, ICAM1
47	intraocular melanoma	13.6	CDKN2A, CD55, CD46, ITGA4, ENG, HLA-A
48	alcoholism	13.6	IL1RN, GPT, SP1, NGF, G6PD, TKT
49	chromoblastomycosis	13.6	IL4, CCR1, CCL3, HLA-A
50	leukocyte-adhesion deficiency syndrome	13.6	SELE, SELL, SELP, ITGA4, ITGAL, ICAM1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 foscarnet, foscarnet sodium hexahydrate, globulin,immune (iv)

MalaCards organs/tissues related to cytomegalovirus infection:

²²

MGI Mouse Phenotypes related to cytomegalovirus infection:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	RAG1, SELP, SELL, MUT, GAD2, THY1
2	hematopoietic system phenotype	MP:0005397	10.6	NCR1, PML, CSF3, THBS2, KLRK1, PDGFRA
3	craniofacial phenotype	MP:0005382	10.2	HDAC1, SP1, SSBP3, TP73, ITGA4, GAD2
4	endocrine/exocrine gland phenotype	MP:0005379	10.0	RBL2, SELL, FUT1, CD40LG, GAD2, RICTOR
5	normal phenotype	MP:0002873	9.5	SSBP3, DAXX, GAD2, HDAC1, SLAMF6, PML
6	no phenotypic analysis	MP:0003012	9.4	F2R, CCR5, ATF6, MTHFR, VCAM1, RBL2
7	embryogenesis phenotype	MP:0005380	9.3	ITGA4, ITGA5, CDK1, CFLAR, BIRC5, RBL2
8	renal/urinary system phenotype	MP:0005367	8.9	TGFB2, CCR1, CASP3, PLA2G4A, PDGFRA, EGFR
9	liver/biliary system phenotype	MP:0005370	8.8	PRKAB1, ATF6, MUT, LGMN, RAG1, IL2
10	immune system phenotype	MP:0005387	8.3	GAD2, HDAC1, RICTOR, PRKAB1, THBS1, TLR12P
11	reproductive system phenotype	MP:0005389	8.3	CCR5, RBL2, RARA, B2M, FUT1, CCL2
12	skeleton phenotype	MP:0005390	8.3	RBL2, TP73, HOXC6, HOXB7, CASP3, MAPK14
13	nervous system phenotype	MP:0003631	8.1	MAVS, PDCD1, ITGAV, ITGA5, MTHFR, MUT
14	integument phenotype	MP:0010771	7.6	TNFRSF1A, TRB@, ERN1, GJB2, HOXC6, CASP8
15	behavior/neurological phenotype	MP:0005386	7.5	HLA-C, NCAM1, APOE, SELE, SELP, RAG1
16	adipose tissue phenotype	MP:0005375	7.5	CDK7, TNFRSF1A, IL6, PIK3C2A, BCL2, IL18
17	mortality/aging	MP:0010768	7.0	GAD2, HDAC9, RICTOR, SLAMF6, PML, PRKAB1
18	digestive/alimentary phenotype	MP:0005381	6.5	IFNG, MUT, BCL2, RARA, RAG1, VWF
19	tumorigenesis	MP:0002006	6.3	TGFB1, THBS2, THBS1, EIF4E, EGFR, KLRK1
20	muscle phenotype	MP:0005369	5.6	ITGAV, CD55, CDKN2A, CDK2, MPO, CFLAR
21	growth/size phenotype	MP:0005378	5.5	GAD2, GFAP, TKT, THBD, THBS1, HDAC9
22	homeostasis/metabolism phenotype	MP:0005376	5.3	GAD2, RICTOR, SLAMF6, SLC39A14, PRKAB1, DBH
23	vision/eye phenotype	MP:0005391	5.2	TNF, TP73, GJB2, CASP3, F2R, ICAM1
24	cardiovascular system phenotype	MP:0005385	4.3	PDCD1, VWF, RBL2, SELE, SELL, SELP
25	cellular phenotype	MP:0005384	4.0	CDH1, BCL2, BIRC5, RARA, RAG1, VCAM1

Articles related to cytomegalovirus infection:

(show top 50)    (show all 179)

id	Title	Authors	Year	Affiliating Genes
1	The changing role of mTOR kinase in the maintenance o f protein synthesis during human cytomegalovirus infection. (21307192)	Clippinger A.J.... Alwine J.C.	2011	MTOR
2	Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections. (21722964)	Szala A.... Cedzynski M.	2011	MBL2
3	Regulation of the subcellular distribution of key cel lular RNA-processing factors during permissive human cytomegalovirus infection. (20164265)	Gaddy C.E.... Colberg-Poley A.M.	2010	SRPK1, CSTF2, PTBP1
4	Association between a polymorphism in the human progr ammed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplant ation. (19581275)	Hoffmann T.W.... Baron C.	2010	PDCD1
5	Survivin expression in odontogenic keratocysts and co rrelation with cytomegalovirus infection. (19659890)	Andric M.... Milasin J.	2010	BIRC5
6	Influence of human cytomegalovirus infection on the N K cell receptor repertoire in children. (20201038)	MonsivA!is-Urenda A.... GonzA!lez-Amaro R.	2010	KIR3DL1, LILRB1, KLRB1
7	Evaluation of interleukin-6 and interleukin-10 in lun g transplant patients with human cytomegalovirus infection. (19624695)	Zedtwitz-Liebenstein K.... Frass M.	2009	IL6
8	The HLA-G 14 bp insertion/deletion polymorphism is a putative susceptible factor for active human cytomegalovirus infection in child ren. (19624485)	Zheng X.Q.... Yan W.H.	2009	HLA-G
9	Effect of cytomegalovirus infection on long-term ren al allograft function (19726300)	Tang B.... Liu D.	2009	TGFB1
10	Induction of both membrane-bound and soluble HLA-G ex pression in active human cytomegalovirus infection. (19619059)	Yan W.H.... Chen S.Y.	2009	HLA-G
11	C-reactive protein mediates the effect of apolipoprotein E on cytomegalovirus infection. (18171282)	Aiello A.E.... Haan M.N.	2008	APOE, CRP
12	HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). (18769594)	McCormick A.L.... Mocarski E.S.	2008	HTRA2
13	Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. (18349127)	Tabata T.... Pereira L.	2008	TGFB1, ITGAV, ITGB6
14	Valproic acid interferes with antiviral treatment in human cytomegalovirus-infected endothelial cells. (18006438)	Michaelis M.... Cinatl J.	2008	HDAC9
15	GJB2 and GJB6 mutations in children with congenital cytomegalovirus infection. (17426645)	Ross S.A.... Boppana S.	2007	GJB2, GJB6
16	Regulation of human fibrolastic 2',5'-oligoadenylate synthetase gene activity in cytomegalovirus infected fibroblast cells (17338231)	Sokolova T.M.... Kushch A.A.	2007	OAS1
17	Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. (17299707)	Ogawa H.... Omori K.	2007	GJB2
18	Acute otitis media associated with cytomegalovirus infection in infants and children. (17618694)	Yano H.... Nishimura H.	2007	GPT
19	Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells. (17202152)	Nystrom K.... Olofsson S.	2007	FUT3, FUT6, FUT1
20	Usefulness of interleukin-10 detection in lung transplant patients with human cytomegalovirus infection with respect to virus persistence. (17667821)	Zedtwitz-Liebenstein K.... Frass M.	2007	IL10
21	Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis. (17575381)	Osame K.... Noda M.	2007	GAD2
22	Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients. (16741880)	Guma M.... Lopez-Botet M.	2006	KLRB1
23	Human cytomegalovirus infection of endothelial cells triggers platelet adhesion and aggregation. (15681423)	Rahbar A.... SAPderberg-NauclAcr C.	2005	VWF
24	Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. (15619605)	Gravel S.P.... Servant M.J.	2005	TBK1
25	Downregulation of the cellular adhesion molecule Thy-1 (CD90) by cytomegalovirus infection of human fibroblasts. (15218185)	Leis M.... Stamminger T.	2004	THY1
26	Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells. (13680213)	Scholz M.... Cinatl J.	2004	F2R, SP1
27	Alteration of cellular RNA splicing and polyadenylation machineries during productive human cytomegalovirus infection. (15557227)	Adair R.... Colberg-Poley A.M.	2004	CSTF2
28	Natural killer cell receptors for major histocompatibility complex class I and related molecules in cytomegalovirus infection. (14989708)	Lopez-Botet M.... Guma M.	2004	LILRB1, HLA-B, LAIR1
29	Hemophagocytic syndrome caused by fulminant ulcerativ e colitis and cytomegalovirus infection: report of a case. (15148644)	Koketsu S.... Nagawa H.	2004	CSF3
30	Reconstitution of T-cell repertoire after autologous stem cell transplantation: influence of CD34 selection and cytomegalovirus infection. (12652471)	Peggs K.S.... Mackinnon S.	2003	TRB@
31	Association of glycoprotein B and immediate early-1 genotypes with human leukocyte antigen alleles in renal transplant recipients with cytomegalovirus infection. (12544891)	RetiA"re C.... Imbert-Marcille B.M.	2003	HLA-A, HLA-B
32	Primary cytomegalovirus infection in an outpatient se tting--laboratory markers and clinical aspects. (14556056)	Just-NA1bling G.... Preiser W.	2003	GPT
33	Disseminated cytomegalovirus infection in Crohn's dis ease following anti-tumour necrosis factor therapy. (12468964)	Helbling D.... Krause M.	2002	TNF
34	Marked gastric foveolar hyperplasia associated with active cytomegalovirus infection. (11197257)	Xiao S.Y.... Hart J.	2001	TGFA
35	Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection. (11438044)	Newkirk M.M.... Marshall G.S.	2001	SNRNP70, RNPC3
36	Altered cellular mRNA levels in human cytomegalovirus -infected fibroblasts: viral block to the accumulation of antiviral mRNAs. (11711622)	Browne E.P.... Shenk T.	2001	ISG20
37	Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38. (10627526)	Johnson R.A.... Huang E.S.	2000	MAPK14, MAP2K3, MAP2K4
38	An association between cytomegalovirus infection and chronic rejection after liver transplantation. (10653376)	Evans P.C.... Alexander G.J.	2000	HLA-B
39	Cytomegalovirus-infected neuroblastoma cells exhibit augmented invasiveness mediated by beta1alpha5 integrin (VLA-5). (10885561)	Scholz M.... Cinatl J.	2000	ITGA5
40	The influence of mycophenolate mofetil on the incidence and severity of primary cytomegalovirus infections and disease after renal transplantation. (10809816)	er Meulen C.G.... Hilbrands L.B.	2000	GPT
41	Chemokines and soluble adhesion molecules in renal transplant recipients with cytomegalovirus infection. (10792384)	NordA... land S.S.	2000	SELL, VCAM1, CCL3
42	Influence of human cytomegalovirus infection on the expression of HOX genes in human embryo lung cells (12212112)	Chen L.Y.... Chen S.Z.	2000	HOXB7
43	Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection. (9621010)	Billstrom M.A.... Worthen G.S.	1998	CCR1, CCR4, CCL7
44	Interrelationship between human cytomegalovirus infection and chemokine (9465667)	Murayama T.	1998	IL8
45	Human cytomegalovirus infection inhibits G1/S transition. (8995690)	Dittmer D.... Mocarski E.S.	1997	CCNB1
46	Relationship between human cytomegalovirus infection and soluble interleukin-2 receptor level (15617342)	Cao Y.... Li A.	1997	IL2RA
47	Expression of human leukocyte antigens class I and cl ass II on cultured biliary epithelial cells after cytomegalovirus infection. (9234487)	Scholz M.... Doerr H.W.	1997	HLA-A
48	Serial monitoring of soluble interleukin-2 receptor as a rapid marker of cytomegalovirus infection and response to antiviral therapy. (8652897)	Rossi S.... Balistreri W.	1996	IL2RA
49	Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients. (7514775)	Dighiero P.... Goureau O.	1994	BLVRB
50	Comparison of shell viral culture and serology for the diagnosis of human cytomegalovirus infection in neonates and immunocompromised subjects. (1327325)	Weber B.... Doerr H.W.	1992	CD40LG

Genes related to cytomegalovirus infection according to GeneCards:

(show top 50)    (show all 186)

id	Symbol	Description	Score	GeneCards Section Context
1	RAG1	recombination activating gene 1	11.0
2	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
3	TLR12P	toll-like receptor 12, pseudogene	11.0	Publications
4	HOXC6	homeobox C6	11.0	Publications
5	MT-RNR1	mitochondrially encoded 12S RNA	11.0	Publications
6	HOXB7	homeobox B7	11.0	Publications
7	KLRB1	killer cell lectin-like receptor subfamily B, member 1	11.0	Publications
8	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	11.0	Publications
9	KLRAP1	killer cell lectin-like receptor subfamily A pseudogene 1	11.0	Publications
10	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	11.0	Publications
11	IFIT3	interferon-induced protein with tetratricopeptide repeats 3	11.0	Publications
12	NCR1	natural cytotoxicity triggering receptor 1	11.0	Publications
13	ULBP2	UL16 binding protein 2	11.0	Publications
14	ULBP1	UL16 binding protein 1	11.0	Publications
15	LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	11.0	Publications
16	FUT5	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	11.0	Publications
17	FUT7	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	11.0	Publications
18	CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	11.0	Publications
19	HOXC4	homeobox C4	11.0	Publications
20	RSAD2	radical S-adenosyl methionine domain containing 2	11.0	Publications
21	NCR3	natural cytotoxicity triggering receptor 3	11.0	Publications
22	NCR2	natural cytotoxicity triggering receptor 2	11.0	Publications
23	MANF	mesencephalic astrocyte-derived neurotrophic factor	11.0	Publications
24	DDAH2	dimethylarginine dimethylaminohydrolase 2	11.0	Publications
25	SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	11.0	Publications
26	THY1	Thy-1 cell surface antigen	11.0	Publications
27	FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	11.0	Publications
28	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	11.0	Publications
29	DAXX	death-domain associated protein	11.0	Publications
30	FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	11.0	Publications
31	HTRA2	HtrA serine peptidase 2	11.0	Publications
32	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
33	GMNN	geminin, DNA replication inhibitor	11.0	Publications
34	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa	11.0	Publications
35	ANAPC4	anaphase promoting complex subunit 4	11.0	Publications
36	CCL8	chemokine (C-C motif) ligand 8	11.0	Publications
37	SLC39A14	solute carrier family 39 (zinc transporter), member 14	11.0	Publications
38	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications
39	MUT	methylmalonyl CoA mutase	11.0	Publications
40	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
41	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
42	SLAMF6	SLAM family member 6	11.0	Publications
43	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	11.0	Publications
44	HLA-E	major histocompatibility complex, class I, E	11.0	Publications
45	GJB6	gap junction protein, beta 6, 30kDa	11.0	Publications
46	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
47	MAVS	mitochondrial antiviral signaling protein	11.0	Publications
48	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
49	KLRD1	killer cell lectin-like receptor subfamily D, member 1	11.0	Publications
50	KLRC1	killer cell lectin-like receptor subfamily C, member 1	11.0	Publications

Pathways related to cytomegalovirus infection according to GeneDecks:

(show top 50)    (show all 234)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	10.6	SP100, OAS1, DDX58, HLA-G, HLA-E, ICAM1
2	Graft-versus-host disease20	10.5	KLRC1, HLA-G, HLA-E, HLA-C, HLA-B, HLA-A
3	Cell adhesion molecules (CAMs)20	10.5	HLA-G, HLA-E, ITGAV, ITGAL, ITGA4, SELP
4	Antigen processing and presentation20	10.4	KIR3DL1, LGMN, HSPA4, HLA-C, KLRD1, KLRC1
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	BCL2, IL2, IL2RA, CCL3, GZMA, TNFRSF1A
6	RAR-Gamma-RXR-Alpha Degradation36	9.9	CDK7, CSF3, CXCL1, CCL5, CCL3, CCL7
7	Natural killer cell mediated cytotoxicity20	9.9	MAPK3, FAS, ITGAL, ULBP2, ULBP1, KIR3DL1
8	Viral myocarditis20	9.4	ITGAL, ICAM1, HLA-DRB1, CASP8, HLA-A, HLA-B
9	Immune response Role of integrins in NK cells cytotoxicity10	9.4	HLA-E, KLRC1, KLRD1, ICAM1, IFNG, MAPK14
10	Immune response_Role of integrins in NK cells cytotoxicity41	9.3	VCAM1, ITGA4, ITGAL, IL8, MAP2K3, MAPK14
11	NFAT Signaling and Lymphocyte Interactions36	9.2	BMP6, CCL3, CCL2, CCL7, CCL8, IL2RB
12	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.2	TGFB2, TNF, FAS, IL2RB, IL2RA, IL2
13	Measles20	9.1	NFKB1, TP73, IRF3, IL2, IL2RA, IL2RB
14	IL-6 Pathway36	9.1	CSF3, CXCL1, PPP2R4, CCL5, CCL3, CCL2
15	Akt Signaling36	9.0	PPP2R4, TNFRSF1A, TNF, CCL5, CCR7, CCL3
16	Chemokine Signaling36	8.9	MAPK14, CCR7, CCL3, CCR3, MAPK3, CCR5
17	Allograft rejection20	8.9	TNF, CD40LG, IL10, HLA-G, HLA-E, HLA-DRB1
18	PGC1Alpha Pathway36	8.9	IL2RB, CCL3, CCL7, CCL8, MAPK14, BMP6
19	Toll-like receptor signaling pathway20	8.8	TBK1, TNF, CCL3, CASP8, NFKB1, IRF3
20	PPAR Pathway36	8.8	TGFB2, EGFR, PDGFRA, TNFRSF1A, TNF, MAPK14
21	CDC42 Pathway36	8.8	ITGAV, MAPK10, MAPK14, ANAPC4, ITGB6, ANAPC5
22	Regulation of eIF4 and p70S6K36	8.8	CCL5, ITGAL, ITGA5, ITGA4, PABPC1, ITGB6
23	NOD-like receptor signaling pathway20	8.4	TNF, CASP8, CCL5, CCL2, MAPK10, MAPK14
24	Influenza A20	8.1	TNFRSF1A, TNF, HLA-DRB1, ICAM1, IFNG, CCL5
25	Malaria20	8.1	CSF3, TGFB2, TGFB1, THBS2, THBS1, KLRK1
26	all-trans-Retinoic Acid Signaling in Brain36	8.1	BMP6, RARA, BCL2, IL10, IL18, IL2
27	Endothelin-1 Signaling Pathway36	7.9	CCL8, MAPK10, MAPK3, IL6, IL4, IL2
28	MIF Mediated Glucocorticoid Regulation36	7.9	CCL5, CCL3, CCL2, CCL7, CCL8, MAPK3
29	PEDF Induced Signaling36	7.8	NFKB1, TNF, CASP8, CCL5, CCL3, CCL2
30	MIF Regulation of Innate Immune Cells36	7.7	CSF3, CXCL1, NFKB1, TNF, CCL5, CCL3
31	Rheumatoid arthritis20	7.7	CCL5, IFNG, ICAM1, HLA-DRB1, TGFB1, TGFB2
32	Toxoplasmosis20	7.7	TGFB2, IL10, CD40LG, BCL2, MAP2K6, TNF
33	STAT3 Pathway36	7.6	CSF3, CXCL1, TNFRSF1A, TNF, CCL5, CCR7
34	Rho Family GTPases36	7.4	BMP6, BCL2, CSF3, CXCL1, TGFB2, TGFB1
35	Pathways in cancer20	7.3	PML, TGFB1, TGFA, EGFR, EGF, PDGFRA
36	Chagas disease (American trypanosomiasis)20	7.3	CCL2, MAPK10, MAPK14, MAPK3, MAP2K4, FAS
37	Glucocorticoid Receptor Signaling36	6.9	IL8, IL6, IL4, IL2RB, IL2RA, IL2
38	ERK Signaling36	6.7	ITGB6, ITGAV, ITGAL, ITGA5, ITGA4, BMP6
39	Cellular Apoptosis Pathway36	6.6	BCL2, PDGFRA, BMP6, TGFB1, TGFB2, TGFA
40	Molecular Mechanisms of Cancer36	6.6	CCR1, CDK2, CFLAR, BCL2, RARA, BMP6
41	MAPK Signaling36	6.5	IL2RA, IL2, ITGB6, ITGAV, ITGAL, ITGA5
42	p70S6K Signaling36	6.4	MAP2K6, MAP2K3, MAP2K4, IL4, IL2RA, IL2
43	PAK Pathway36	6.2	CASP8, CASP3, CCL5, CCL3, CCL2, CCL7
44	Cytokine-cytokine receptor interaction20	6.1	CD40LG, IL10, CSF3, CXCR1, CXCL1, TGFB2
45	TGF-Beta Pathway36	5.8	MAP2K6, BMP6, IL8, IL6, IL4, IL2RB
46	JAK-STAT Pathway36	5.8	TGFB1, TGFA, EGFR, EGF, PDGFRA, NFKB1
47	Tec Kinases Signaling36	5.7	TGFA, EGFR, EGF, PDGFRA, NFKB1, TNFRSF1A
48	MAPK Family Pathway36	5.6	MAP2K4, BMP6, BCL2, MAP2K3, MAP2K6, IL8
49	Antioxidant Action of Vitamin-C36	5.5	IL8, IL6, IL4, IL2RB, IL2RA, IL2
50	p38 Signaling36	5.4	NFKB1, SP1, DAXX, TNFRSF1A, TNF, CASP3

Compounds related to cytomegalovirus infection according to GeneDecks:

(show top 50)    (show all 444)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.0	BLVRB, CFLAR, FUT3, CD38, MAP2K6, MAP2K3
2	ionomycin32	10.8	RAG1, GZMA, MAPK3, CCL3, CALR, TNFRSF1A
3	cyclophosphamide32 34 9 9	13.6	ITGA4, ITGAL, MBL2, F9, TRB@
4	dmso32	10.3	SELP, BMP6, CCR1, F2R, HSPA4, TP73
5	ascorbic acid32 18	11.1	CD40LG, CD9, IL2RA, FAS, ENG, MAPK3
6	egcg32	10.1	CDK2, MAPK3, MAPK14, MAPK10, CCL5, SP1
7	slea32	10.0	SELE, SELL, SELP, FUT3, CD40LG, CDH1
8	polyethylene glycol32	10.0	SELE, MPO, CD9, CDH1, APOE, ANPEP
9	roscovitine32	10.0	BIRC5, CDK9, CDK7, CDK1, MAPK3, MAPK14
10	homocysteine32 18	10.6	PIK3C2A, VWF, SELE, SELP, VCAM1, IL18
11	aspartate32	9.5	PIK3C2A, SELP, BMP6, RAG1, RARA, LGMN
12	latex32	9.4	VWF, CDK1, CD9, CDH1, ITGAL, IL18
13	camptothecin32 42 9 9	12.0	BIRC5, BCL2, CFLAR, CDK2, CDKN2A, CDKN3
14	mycophenolate mofetil32 9 9	11.0	SELE, SELP, CD40LG, IL10, IL18, IL2
15	calcium32 9 18 9	12.0	PIK3C2A, VWF, RARA, LILRB1, BLVRB, BIRC5
16	chloramphenicol32 9 9	10.9	SELE, RARA, MPO, CDKN2A, CDKN3, CD55
17	norepinephrine32 9 18 9	11.9	PIK3C2A, VWF, SELE, SELL, SELP, VCAM1
18	ifn-alpha32	8.7	CDK2, CDKN2A, IRF3, IL10, IL18, IL2
19	ribavirin32 34 9 9	11.6	CD40LG, ISG20, IL10, IL18, IL2, IL4
20	resveratrol32 9 18 9	11.6	BIRC5, BCL2, MTOR, CDK2, CDK1, FAS
21	okadaic acid32 42	9.4	BMP6, BCL2, MTOR, CDK9, CDK2, CDKN3
22	quercetin32 42 9 18 9	12.4	PIK3C2A, SELE, VCAM1, BIRC5, BCL2, CDK2
23	n acetylcysteine32	8.3	VWF, SELE, SELP, VCAM1, BIRC5, CDKN2A
24	arsenite32 18	9.2	RARA, BIRC5, BCL2, MTOR, CFLAR, CDK2
25	tetracycline32 9 9	10.1	VWF, CDK2, CDKN2A, CD40LG, IL18, FAS
26	polyinosinic-polycytidylic acid32	8.1	SELE, VCAM1, IRF3, IL10, IL18, IL2
27	anisomycin32 42 9 9	11.1	MTOR, CFLAR, IL2RA, IL6, FAS, MAP2K6
28	staurosporin32	8.1	BCL2, CDKN3, ITGAL, IL8, MAPK14, MAPK10
29	estrogen32	8.1	VWF, SERPINB9, SERPINA1, RARA, MTHFR, CDK7
30	aspirin32 34 18	10.0	VWF, SELE, SELL, SELP, BMP6, BIRC5
31	lipid32	8.0	PIK3C2A, NCAM1, KIR3DL1, SELE, SERPINA1, VCAM1
32	retinoid32	7.9	SELL, BMP6, RARA, BCL2, CDH1, CD38
33	cholesterol32 9 18 9	10.7	PIK3C2A, VWF, SELE, SELP, SERPINA1, VCAM1
34	polymyxin b32	7.7	SELE, VCAM1, IL10, IL1RN, IL4, IL6
35	progesterone32 42 9 18 9	11.7	NCAM1, RARA, BIRC5, BCL2, CDK2, CDKN2A
36	pentoxifylline32 9 9	9.6	SELL, SELP, VCAM1, BMP6, MPO, CD9
37	diphenyleneiodonium32	7.6	VCAM1, MPO, CDKN3, IL8, MAPK3, MAPK14
38	wortmannin32 42	8.4	PIK3C2A, VCAM1, BIRC5, BCL2, MTOR, CFLAR
39	troglitazone32 42 9 9	10.3	SELE, VCAM1, BMP6, RARA, BIRC5, BCL2
40	imatinib32 34 9 9	10.3	SELL, BMP6, RARA, BIRC5, BCL2, MTOR
41	nitric oxide32 9 18 9	10.2	NCAM1, SELE, SELP, SERPINA1, VCAM1, BMP6
42	cytochalasin d32 42	8.0	VWF, SELE, SELL, VCAM1, CDKN3, CDH1
43	mg 13232 42	7.9	RARA, BIRC5, CFLAR, CDK2, CDKN2A, CDH1
44	il 1032	6.8	BMP6, IL10, IL18, IL1RN, IL2, IL2RA
45	tamoxifen32 34 9 9	9.2	SELE, SERPINB9, VCAM1, BMP6, RARA, BIRC5
46	thymidine32 18	7.1	SERPINA1, BMP6, RARA, BIRC5, MTHFR, B2M
47	butyrate32	5.2	BMP6, RARA, BIRC5, BCL2, B2M, MPO
48	retinoic acid32 42 18	6.8	NCAM1, VWF, SELL, SELP, VCAM1, BMP6
49	genistein32 9 18 9	7.1	SELE, SELL, SELP, VCAM1, BIRC5, BCL2
50	pd 98,05932	4.0	VCAM1, BMP6, RARA, BIRC5, BCL2, MTOR

Cellular components related to cytomegalovirus infection according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	10.7	HLA-G, HLA-E, ULBP1, ULBP2, B2M, HLA-A
2	phagocytic vesicle membrane	GO:030670	10.2	HLA-E, HLA-C, HLA-G, HLA-A, B2M, HLA-B
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	CALR, HLA-G, HLA-E, HLA-DRB1, HLA-C, HLA-B
4	ER to Golgi transport vesicle membrane	GO:012507	10.1	HLA-B, HLA-A, HLA-C, HLA-DRB1, HLA-E, HLA-G
5	nucleoplasm	GO:005654	9.5	HDAC1, CASP3, CCNT1, CCNB1, MAPK10, MAPK14
6	integral to plasma membrane	GO:005887	9.5	ICAM1, F2R, HLA-A, ITGAV, CCR3, CCR1
7	cell surface	GO:009986	9.2	CDH1, ULBP2, RARA, VCAM1, NCAM1, TGFB2
8	platelet alpha granule lumen	GO:031093	9.1	VWF, SERPINA1, F5, EGF, TGFB2, THBS1
9	external side of plasma membrane	GO:009897	8.7	ITGAL, ITGAV, IL2RB, IL4, FAS, ENG
10	cytosol	GO:005829	8.6	IFIT3, CTSH, OAS1, DAXX, DDX58, TBK1
11	plasma membrane	GO:005886	6.9	GAD2, HLA-DRB1, HLA-C, HLA-B, HLA-A, GJB6
12	nucleus	GO:005634	6.7	CDK1, SP100, CDK7, HDAC9, HDAC1, PIK3C2A
13	extracellular region	GO:005576	6.4	THBS1, THBS2, CCL7, CXCL1, DBH, TGFB2
14	cytoplasm	GO:005737	5.8	FAS, CDK7, CDH1, IRF3, IL1RN, APOE
15	extracellular space	GO:005615	4.7	CSF3, CCL2, CCL7, CCL8, MANF, ENG

Biological processes related to cytomegalovirus infection according to GeneDecks:

(show top 50)    (show all 89)

id	Name	GO ID	Score	Top Affiliating Genes
1	type I interferon-mediated signaling pathway	GO:060337	11.0	IFIT2, HLA-C, IFIT3, ISG20, IRF3, HLA-A
2	fucosylation	GO:036065	11.0	FUT7, FUT9, FUT5, FUT3, FUT6
3	L-fucose catabolic process	GO:042355	10.9	FUT6, FUT1, FUT5, FUT7, FUT9
4	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.7	HLA-C, B2M, HLA-A, HLA-B, HLA-G, HLA-E
5	response to virus	GO:009615	10.6	DDX58, LILRB1, ISG20, CCL8, CCL5, TBK1
6	chemokine-mediated signaling pathway	GO:070098	10.6	CXCR1, CCR5, CCL5, CCR1, CCL2, CCR4
7	heterophilic cell-cell adhesion	GO:007157	10.4	SELP, VCAM1, ITGA4, ITGA5, ICAM1, ITGAL
8	leukocyte cell-cell adhesion	GO:007159	10.4	SELE, SELP, CD40LG, ITGA4, ITGA5, ICAM1
9	regulation of immune response	GO:050776	10.2	KIR3DL1, KLRD1, KLRC1, HLA-G, HLA-E, VCAM1
10	response to lipopolysaccharide	GO:032496	10.2	THBD, CASP8, PLA2G4A, NGF, SELP, TNFRSF1A
11	MyD88-independent toll-like receptor signaling pathway	GO:002756	10.2	MAP2K6, CDK1, TBK1, IRF3, MAP2K3, MAP2K4
12	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.2	MAP2K4, MAP2K3, MAP2K6, MAPK3, NFKB1, TBK1
13	toll-like receptor 3 signaling pathway	GO:034138	10.2	IRF3, MAP2K6, MAP2K3, MAPK3, MAPK14, MAPK10
14	Toll signaling pathway	GO:008063	10.2	NFKB1, CDK1, MAP2K6, MAP2K3, IRF3, MAPK3
15	toll-like receptor 4 signaling pathway	GO:034142	10.1	MAP2K6, MAPK3, TBK1, IRF3, CDK1, MAP2K3
16	chemotaxis	GO:006935	10.1	CCR1, CCR3, CCL5, CXCL1, CXCR1, CCL8
17	elevation of cytosolic calcium ion concentration	GO:007204	9.9	CCR4, PDGFRA, F2R, CCR7, CCR3, CCR1
18	positive regulation of gene expression	GO:010628	9.9	TGFB1, NGF, CTSH, CALR, CCL5, CCL3
19	activation of MAPK activity	GO:000187	9.9	TNF, CDK1, MAP2K6, MAP2K3, MAPK3, MAPK14
20	transforming growth factor beta receptor signaling pathway	GO:007179	9.9	TGFB2, CCL2, SP1, ENG, CDK9, TFDP1
21	virus-host interaction	GO:019048	9.9	PML, CFLAR, HLA-C, TNFRSF1A, TBK1, DDX58
22	defense response to virus	GO:051607	9.8	BCL2, RSAD2, OAS1, IFNG, MAVS, IL6
23	interferon-gamma-mediated signaling pathway	GO:060333	9.8	NCAM1, VCAM1, B2M, IRF3, IFNG, ICAM1
24	innate immune response	GO:045087	9.8	MAPK10, MAPK14, MAPK3, MBL2, MAP2K4, MAP2K3
25	B cell differentiation	GO:030183	9.7	CD40LG, RAG1, HDAC9, VCAM1, IL10, IL4
26	cell adhesion	GO:007155	9.7	ITGAL, IL2, ENG, CCL2, CCR3, F5
27	response to glucocorticoid stimulus	GO:051384	9.5	FAS, IL6, IL1RN, IL10, CCL2, CCL5
28	cellular calcium ion homeostasis	GO:006874	9.5	CALR, CCL8, TGFB1, CCL5, CCL3, CCL7
29	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	IRF3, IL18, MAPK3, MAPK14, CCL2, CCL3
30	response to hypoxia	GO:001666	9.3	THBS1, TGFB1, TGFB2, PML, CRP, TNFRSF1A
31	protein phosphorylation	GO:006468	9.3	CCL5, ERN1, SRPK1, TGFB1, TGFB2, POLR2L
32	induction of apoptosis	GO:006917	9.3	TNF, TGFB2, THBS1, DAXX, ERN1, CASP3
33	cell cycle arrest	GO:007050	9.3	TP73, CDKN2A, CALR, PML, PRKAB1, HTRA2
34	platelet degranulation	GO:002576	9.2	VWF, TGFB1, THBS1, EGF, F5, CD9
35	positive regulation of cell migration	GO:030335	9.2	EGFR, CCL3, PDGFRA, CTSH, ITGAV, CCL7
36	cytokine-mediated signaling pathway	GO:019221	9.1	NCAM1, HLA-C, HLA-DRB1, HLA-E, HLA-G, TNFRSF1A
37	immune response	GO:006955	9.0	THBS1, IL18, GZMA, ULBP2, ULBP1, RAG1
38	cell surface receptor signaling pathway	GO:007166	8.9	IL2RA, CXCR1, EGFR, KLRD1, IFNG, CCR1
39	angiogenesis	GO:001525	8.9	MAPK14, ANPEP, IL8, IL18, ITGAV, ITGA5
40	anti-apoptosis	GO:006916	8.7	CCL2, FAS, IL10, TNF, APOE, IL2
41	platelet activation	GO:030168	8.6	TGFB2, TGFB1, THBS1, EGF, PLA2G4A, F2R
42	MAPK cascade	GO:000165	8.6	CDK1, IL18, MAPK3, CCL2, CCL3, CCL5
43	apoptotic process	GO:006915	8.5	IL2RA, FAS, CDH1, CDK1, CFLAR, BCL2
44	blood coagulation	GO:007596	8.5	EGF, THBD, THBS1, TGFB1, TGFB2, HDAC1
45	negative regulation of apoptotic process	GO:043066	8.5	EGFR, BCL2, CD38, ITGAV, IL1RN, IL4
46	response to drug	GO:042493	8.1	THBS1, B2M, CDK1, MAP2K6, CDH1, CD38
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	CDK9, CDKN2A, CDK7, LILRB1, RARA, IL6
48	positive regulation of transcription, DNA-dependent	GO:045893	7.9	RARA, SP100, SP1, TNF, TP73, F2R
49	inflammatory response	GO:006954	7.7	HDAC9, CXCR1, CXCL1, TGFB1, NFKB1, MAP2K3
50	positive regulation of cell proliferation	GO:008284	7.5	SSBP3, CTSH, PLA2G4A, PDGFRA, TGFB1, HDAC1

Molecular functions related to cytomegalovirus infection according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	fucosyltransferase activity	GO:008417	11.0	FUT1, FUT9, FUT7, FUT6, FUT5, FUT3
2	alpha-(1->3)-fucosyltransferase activity	GO:046920	10.9	FUT7, FUT9, FUT3, FUT5, FUT6
3	MHC class I receptor activity	GO:032393	10.8	HLA-E, HLA-C, HLA-B, LILRB1, ULBP1, HLA-A
4	C-C chemokine receptor activity	GO:016493	10.6	CCR1, CCR4, CCR5, CCR3, CCR7
5	integrin binding	GO:005178	10.5	ITGA5, CD9, VCAM1, VWF, ITGB6, ICAM1
6	chemokine receptor activity	GO:004950	10.4	CCR4, CCR1, CCR3, CXCR1, CCR5
7	protein kinase activity	GO:004672	10.3	CDK9, POLR2L, SRPK1, TBK1, CCL5, CCL2
8	heparin binding	GO:008201	10.0	THBS2, THBS1, CCL5, CCL2, CCL7, SELP
9	chemokine activity	GO:008009	9.9	CXCL1, CCL5, IL8, CCL3, CCL2, CCL7
10	protease binding	GO:002020	9.8	BCL2, SERPINA1, SERPINB9, SELL, TNFRSF1A, TNF
11	MAP kinase kinase activity	GO:004708	9.7	MAP2K6, MAPK10, TGFA, MAP2K3, MAPK14
12	transmembrane signaling receptor activity	GO:004888	9.5	SELE, EGFR, KLRD1, THBD, KLRB1, NCR2
13	protein homodimerization activity	GO:042803	9.2	LILRB1, RAG1, VWF, PDGFRA, G6PD, TKT
14	cytokine activity	GO:005125	8.5	IFNG, TNF, IL4, IL6, CSF3, IL2
15	growth factor activity	GO:008083	7.9	IL4, CSF3, IL2, BMP6, TGFB2, TGFB1
16	protein binding	GO:005515	4.2	CDK2, MAPK14, MAPK10, CCNB1, CCR5, CCR1