MCID: CYT005
MIFTS: 56

Cytomegalovirus Retinitis malady

Rare diseases category

Summaries for Cytomegalovirus Retinitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that... more...

MalaCards: Cytomegalovirus Retinitis is related to acquired immunodeficiency syndrome and uveitis. An important gene associated with Cytomegalovirus Retinitis is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and Staphylococcus aureus infection. The drugs ganciclovir and ganciclovir sodium and the compounds mdms and mip 1alpha have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Cytomegalovirus Retinitis

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

cytomegalovirus retinitis 44 63


Related Diseases for Cytomegalovirus Retinitis

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18GeneCards, 19GeneDecks
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Diseases related to Cytomegalovirus Retinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome31.0HLA-B, CSF2, IL2, CCR5, CCR2, CXCL12
2uveitis30.7TNF, HLA-A, HLA-B, CCR5, IL10, IFNG
3intraocular lymphoma30.4IL10
4hodgkin's lymphoma30.2CSF2, HLA-A, IL2, HLA-B
5encephalitis30.1CD9, CCR5, HLA-B
6leprosy30.1HLA-DRB1, IL2
7tuberculoid leprosy30.0IL10, IFNG
8leukemia30.0IFNG, CD9, CSF2, HLA-DRB1, TNF, HLA-B
9aplastic anemia30.0FASLG, IFNG, CSF2
10systemic lupus erythematosus30.0IL10RA, IL10, IL2, IFNG, CCR5, HLA-A
11pneumonia30.0CSF2, TNF, IL10, CD9
12diabetes mellitus29.9HLA-B, HLA-DQB1, TNF, HLA-A, HLA-DRB1
13myeloma29.9CXCL12, HLA-B, FASLG, IL2, CSF2, CD9
14arthritis29.7CCR5, TNF, IL10, IFNG, CSF2, HLA-A
15tuberculosis29.6IL10, IL2, IFNG, CXCL12, HLA-A, HLA-DQB1
16rheumatoid arthritis29.5IL2, CXCL12, CCR5, IFNG, IL10, IL10RA
17retinitis11.4
18retinal detachment10.6
19cystoid macular edema10.5
20good syndrome10.3
21central retinal vein occlusion10.3
22lupus erythematosus10.3
23retinal vein occlusion10.3
24hematopoietic stem cell transplantation10.3
25choroiditis10.2
26wegener's granulomatosis10.2
27lymphoblastic leukemia10.2
28congenital cytomegalovirus10.2
29common variable immunodeficiency10.2
30cataract10.2
31neuritis10.2
32optic neuritis10.2
33anterior uveitis10.2
34cytomegalovirus infection10.2
35hiv/aids10.2
36endotheliitis10.2
37periapical granuloma10.1CCR5
38toxic epidermal necrolysis10.1FASLG
39felty's syndrome10.1CSF2
40aphthous stomatitis10.1HLA-B
41blau syndrome10.1TNF
42thyroiditis10.1FASLG, HLA-DRB1
43vogt-koyanagi-harada disease10.1FASLG, HLA-DRB1
44multiple sclerosis 110.1HLA-DRB1, HLA-DQB1
45stomatitis10.1CSF2
46autoimmune lymphoproliferative syndrome10.1IL10, FASLG
47human immunodeficiency virus infectious disease10.1HLA-A, FASLG
48capillary leak syndrome10.1CSF2, IL2
49dementia10.0CD9, CCR5, CXCL12
50choriocarcinoma10.0FASLG, CD9, CSF2

Graphical network of the top 20 diseases related to Cytomegalovirus Retinitis:



Diseases related to cytomegalovirus retinitis

Symptoms for Cytomegalovirus Retinitis

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Drugs & Therapeutics for Cytomegalovirus Retinitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Cytomegalovirus Retinitis

Drug clinical trials:

Search ClinicalTrials for Cytomegalovirus Retinitis

Search NIH Clinical Center for Cytomegalovirus Retinitis

Search CenterWatch for Cytomegalovirus Retinitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Cytomegalovirus Retinitis

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Anatomical Context for Cytomegalovirus Retinitis

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34MalaCards
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MalaCards organs/tissues related to Cytomegalovirus Retinitis:

34
Eye, Retina, T cells, Bone, Bone marrow, Testes, Endothelial, Liver, Heart, Nk cells, Lung

Animal Models for Cytomegalovirus Retinitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Cytomegalovirus Retinitis:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8CSF2, CCR2, FASLG, HLA-DQB1, IFNG
2MP:00053917.8IL10, IFNG, TNF, FASLG, CCR5, CCR2
3MP:00053697.6IFNG, HLA-DQB1, TNF, CXCL12, CCR5, IL10
4MP:00053907.3TNF, FASLG, CCR2, IFNG, IL10, CSF2
5MP:00053797.3CSF2, IL10, IL2, FASLG, TNF, HLA-DQB1
6MP:00020067.3IFNG, IL2, CSF2, IL10, CCR5, CCR2
7MP:00030127.1HLA-B, TNF, CXCL12, CCR2, CCR5, IFNG
8MP:00053817.0IL10, CCR2, HLA-DQB1, FASLG, IL2, IFNG
9MP:00053707.0CXCL12, HLA-DQB1, TNF, FASLG, IL2, CCR2
10MP:00036316.9HLA-B, IL10, IFNG, CCR5, CCR2, TNF
11MP:00053886.7IFNG, IL2, FASLG, TNF, HLA-DQB1, CCR2
12MP:00053866.7HLA-B, HLA-DQB1, IL10, IL2, TNF, CSF2
13MP:00053766.7TNF, FASLG, IFNG, CCR2, IL2, IL10
14MP:00053856.6CXCL12, CCR2, IFNG, IL10, CSF2, FASLG
15MP:00053846.4IL2, CCR2, IFNG, CSF2, CXCL12, IL10RA
16MP:00053896.4IL10, IL2, IFNG, CCR5, CXCL12, FASLG
17MP:00053786.4IFNG, CSF2, TNF, CD9, IL2, IL10
18MP:00107686.2CSF2, CXCL12, CCR5, HLA-B, HLA-DQB1, TNF
19MP:00053975.6CCR5, CSF2, IL10RA, IL10, HLA-B, HLA-DQB1
20MP:00053875.5HLA-DQB1, TNF, CSF2, IL10RA, IL10, IL2

Publications for Cytomegalovirus Retinitis

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53PubMed
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Articles related to Cytomegalovirus Retinitis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Herpetic (non-cytomegalovirus) retinal infections in patients with the acquired immunodeficiency syndrome. (23544389)
2013
2
A messenger at the door: cytomegalovirus retinitis in myeloma patients with progressive disease. (23790037)
2013
3
Telemedicine screening for cytomegalovirus retinitis using digital fundus photography. (23756239)
2013
4
Retinal metastasis simulating cytomegalovirus retinitis. (22938704)
2012
5
Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation. (22657564)
2012
6
Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis. (22837196)
2012
7
The epidemiology and incidence of cytomegalovirus retinitis in the HIV population in Singapore over 6 years. (23074211)
2012
8
Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus. (21396623)
2011
9
Cytomegalovirus retinitis in an immunocompromised infant: a case report and review of the literature. (21941498)
2011
10
Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis. (21742304)
2011
11
Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS. (19818505)
2010
12
Intravitreal ganciclovir in the management of non-AIDS-related human cytomegalovirus retinitis. (20379302)
2010
13
Good's syndrome in a patient with cytomegalovirus retinitis. (18382022)
2008
14
Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation. (17220797)
2007
15
Cytomegalovirus retinitis following intravitreal injection of triamcinolone: report of two cases. (17403022)
2007
16
Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. (18052600)
2007
17
Long-term follow-up of a cohort of HIV-infected patients who discontinued maintenance therapy for cytomegalovirus retinitis. (16632459)
2006
18
Indocyanine green angiographic findings in a cytomegalovirus retinitis patient. (16334614)
2005
19
A case of immune recovery vitritis induced by donor leukocyte infusion for the treatment of cytomegalovirus retinitis. (16146543)
2005
20
PCR with the aqueous humor, blood leukocytes and vitreous of patients affected by cytomegalovirus retinitis and immune recovery uveitis. (14688435)
2004
21
Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence. (12706995)
2003
22
Interleukin-2 immunotherapy of murine cytomegalovirus retinitis during MAIDS correlates with increased intraocular CD8+ T-cell infiltration. (12711843)
2003
23
Mortality risk for patients with cytomegalovirus retinitis and acquired immune deficiency syndrome. (14583871)
2003
24
Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy. (12523893)
2003
25
Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. (12895694)
2003
26
Incidence and management of cataract after retinal detachment repair with silicone oil in immune compromised patients with cytomegalovirus retinitis. (14644210)
2003
27
Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS. (11931782)
2002
28
HIV and cytomegalovirus viral load and clinical outcomes in AIDS and cytomegalovirus retinitis patients: Monoclonal Antibody Cytomegalovirus Retinitis Trial. (11919489)
2002
29
Protease inhibitor therapy is associated with markedly prolonged time to relapse and improved survival in AIDS patients with cytomegalovirus retinitis. (11564333)
2001
30
Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. (11120934)
2001
31
Cystoid macular edema in patients with acquired immune deficiency syndrome and cytomegalovirus retinitis. (11071031)
2000
32
Highly active antiretroviral therapy-related immune recovery in AIDS patients with cytomegalovirus retinitis. (10811078)
2000
33
HIV associated cytomegalovirus retinitis in Melbourne, Australia. (10961210)
2000
34
Visual and anatomic outcomes associated with posterior segment complications after ganciclovir implant procedures in patients with AIDS and cytomegalovirus retinitis. (10088738)
1999
35
Cystoid macular edema following immune recovery and treatment with cidofovir for cytomegalovirus retinitis. (10541898)
1999
36
Successive intraocular nocardiosis and cytomegalovirus retinitis after cardiac transplantation. (9682720)
1998
37
Optic nerve head neovascularization in a patient with inactive cytomegalovirus retinitis and immune recovery. (9727534)
1998
38
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. (9194724)
1997
39
New therapies for cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. (9109331)
1997
40
Successful use of cidofovir in treating AIDS-related cytomegalovirus retinitis, encephalitis, and esophagitis. (9215660)
1997
41
Antibody alone does not prevent experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency (MAIDS). (9380340)
1997
42
Convenient twice daily foscarnet in induction therapy of AIDS-associated cytomegalovirus retinitis. The Foscarnet Italian Study Group. (9030380)
1997
43
Cytomegalovirus retinitis: diagnosis and status of systemic therapy. (9058611)
1997
44
An economic evaluation of oral compared with intravenous ganciclovir for maintenance treatment of newly diagnosed cytomegalovirus retinitis in AIDS patients. (8829030)
1996
45
Cytomegalovirus retinitis and viral resistance. Prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group. (8660163)
1996
46
Treatment of cytomegalovirus retinitis: A growing number of options. (22514462)
1996
47
Long survival in AIDS-related cytomegalovirus retinitis. (8680895)
1996
48
Effectiveness of entoptic perimetry for locating peripheral scotomas caused by cytomegalovirus retinitis. (8660166)
1996
49
Treatment of cytomegalovirus retinitis in patients with AIDS. (8678370)
1996
50
Effect of foscarnet therapy on human immunodeficiency virus p24 antigen levels in AIDS patients with cytomegalovirus retinitis. (1323624)
1992

Variations for Cytomegalovirus Retinitis

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Expression for genes affiliated with Cytomegalovirus Retinitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cytomegalovirus Retinitis

Search GEO for disease gene expression data for Cytomegalovirus Retinitis.

Pathways for genes affiliated with Cytomegalovirus Retinitis

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 31KEGG, 61Thomson Reuters, 54QIAGEN, 39NCBI BioSystems Database, 58SinoBiological, 5Cell Signaling Technology
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Pathways related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CXCL12, CCR5, CCR2
29.3HLA-DQB1, IL10, HLA-DRB1
3
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.3IL2, HLA-DRB1, HLA-DQB1
4
Show member pathways
9.3HLA-DQB1, HLA-DRB1, IL2
59.0CSF2, IL2, IFNG
69.0HLA-B, HLA-DRB1, HLA-A, HLA-DQB1
79.0HLA-DRB1, HLA-B, HLA-A, HLA-DQB1
8
Show member pathways
9.0HLA-DRB1, HLA-DQB1, HLA-A, HLA-B
99.0IL10RA, TNF, IL10
109.0IL2, HLA-DRB1, IFNG
118.9IL10, IL2, IFNG
128.8IFNG, CCR2, TNF
138.8TNF, IFNG, FASLG
14
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.8IFNG, FASLG, TNF
15
Show member pathways
8.7FASLG, TNF, HLA-DQB1, HLA-A
168.7CCR2, FASLG, IL10, CXCL12, IL2
178.6IFNG, TNF, IL10
188.5TNF, IL2, IFNG
198.5HLA-DRB1, CD9, CSF2, TNF
20
Show member pathways
Type III interferon signaling39
8.4IFNG, IL2, CSF2, IL10RA, IL10
218.3IL10, IFNG, FASLG, TNF
228.3TNF, IL10, CSF2, IFNG
238.3IL2, TNF, CCR2, IFNG
24
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.1FASLG, CCR5, IFNG, HLA-DRB1, HLA-A, IL2
25
Show member pathways
IL27-mediated signaling events39
8.1IL10, IFNG, TNF, IL2
268.1TNF, IL2, IFNG, IL10
27
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.0FASLG, TNF, HLA-A, IFNG, HLA-B
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.0FASLG, CSF2, IL2, TNF, IFNG
29
Show member pathways
Ras signaling in the CD4+ TCR pathway39
7.9IFNG, FASLG, IL2, TNF, HLA-A
30
Show member pathways
7.9TNF, HLA-DRB1, HLA-DQB1, IFNG, IL10
31
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
7.8IL10RA, IFNG, IL2, TNF, IL10
32
Show member pathways
7.8HLA-DQB1, TNF, IFNG, HLA-DRB1, IL2
33
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
7.8IL10, IL2, IFNG, FASLG, TNF
347.8CXCL12, HLA-DRB1, TNF, HLA-DQB1, IFNG, CSF2
357.7HLA-DRB1, IFNG, IL10, IL10RA, HLA-DQB1, HLA-A
367.6HLA-DQB1, IFNG, TNF, IL10, IL10RA, HLA-DRB1
37
Show member pathways
7.6HLA-DRB1, HLA-DQB1, HLA-A, HLA-B, IL2, CSF2
38
Show member pathways
7.5TNF, CXCL12, IFNG, IL10RA, IL2, IL10
39
Show member pathways
7.5TNF, FASLG, IL2, IL10, CSF2, IFNG
40
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
7.5CCR5, IL10, IL2, IFNG, TNF, CSF2
417.4TNF, IL2, HLA-DRB1, CSF2, HLA-B, HLA-A
427.4CSF2, IL10, IFNG, TNF, HLA-DRB1, IL2
43
Show member pathways
7.4IL2, CXCL12, IL10RA, CSF2, IL10, CCR2
44
Show member pathways
7.4CXCL12, CCR2, CCR5, IL2, IL10RA, TNF
45
Show member pathways
7.4CXCL12, CSF2, TNF, CCR2, CCR5, IL2
46
Show member pathways
Immune response CD16 signaling in NK cells61
7.2CSF2, HLA-A, HLA-B, TNF, FASLG, IFNG
47
Show member pathways
6.9IL2, IL10RA, IFNG, TNF, IL10, CCR5
48
Show member pathways
6.8TNF, HLA-A, HLA-B, HLA-DQB1, HLA-DRB1, FASLG
49
Show member pathways
6.5TNF, FASLG, CXCL12, CCR2, CCR5, CSF2
50
Show member pathways
5.8TNF, IL2, IL10RA, IFNG, FASLG, CXCL12

Compounds for genes affiliated with Cytomegalovirus Retinitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1mdms469.1CXCL12, IL10, CD9, CSF2, CCR5
2mip 1alpha469.0CSF2, IL10, CCR5, TNF
3glatiramer acetate46 129.8IL10, IL2, HLA-DRB1, IFNG
4cyclophosphamide46 52 1210.8CXCL12, CSF2, IL2, IL10, FASLG
5groalpha468.7CSF2, TNF, CXCL12, CCR5, IL10
6polysaccharide468.7CSF2, HLA-B, FASLG, CXCL12, CCR5, CD9
75-aza-2deoxycytidine468.5IFNG, HLA-B, HLA-A, CXCL12, FASLG
8zidovudine46 52 1210.5CXCL12, CSF2, IL10, IL2, CCR5, CD9
9ifn-alpha468.5CSF2, IL10, IL2, IFNG, CXCL12, FASLG
10gold sodium thiomalate468.5HLA-DRB1, TNF, IFNG, IL2
11imiquimod46 62 30 1211.5IL10, CSF2, IFNG, FASLG, TNF
125fluorouracil468.5CXCL12, FASLG, HLA-A, IFNG, IL2, CSF2
13interferon gamma468.4IFNG, IL2, IL10, TNF
14ribavirin46 52 1210.4CSF2, IFNG, IL10, CCR5, HLA-B, IL2
15ccl346 309.3IL10, CXCL12, CCR5, IFNG, TNF
16rapamycin468.3IFNG, IL10, IL2, CCR5, CXCL12, FASLG
17cimetidine46 30 1210.3HLA-B, IL10, CD9, IL2
18rituximab46 52 1210.3TNF, CSF2, IL10, IL2, CXCL12, FASLG
19simvastatin46 52 62 30 25 1213.3IL10, TNF, IFNG, CCR5, FASLG
20ivig468.2IL10, CCR5, FASLG, IFNG, CSF2, TNF
21rolipram46 62 3010.2TNF, IFNG, IL10, CD9
22il-12468.2CSF2, IL10, IL2, IFNG, TNF
23tarc468.2TNF, CSF2, IL10, IFNG, CCR5, CXCL12
24okt3468.2CSF2, IL10, IL2, IFNG, TNF
25gm-csf46 309.2IL10, IFNG, IL2, TNF, CSF2
26herbimycin a46 629.1IL2, TNF, CXCL12, IFNG, CSF2
27hydrocortisone46 3 62 1211.0CSF2, IL2, IL10, IFNG, TNF
28sb 20358046 629.0IL10, TNF, FASLG, CSF2, CXCL12, IFNG
29polyinosinic-polycytidylic acid468.0IFNG, IL10, IL2, TNF, HLA-B
302,5-oligoadenylate468.0IL2, IFNG, TNF, HLA-B, IL10
31endotoxin468.0IL10, CSF2, IFNG, TNF, HLA-B, FASLG
32mycophenolate mofetil46 52 1210.0TNF, IFNG, IL10, IL2
33thalidomide46 52 62 1210.9CSF2, IL10, IL2, IFNG, FASLG, TNF
34ionomycin467.9TNF, CSF2, IFNG, IL10, IL2, FASLG
35calcitriol46 62 25 1210.8CSF2, IL10, IFNG, TNF, IL2
36actinomycin d467.8IL2, FASLG, CXCL12, TNF, IFNG, CCR5
37histamine46 30 259.7TNF, CSF2, IL10, IL2, IFNG, CCR5
38il 10467.7IFNG, CCR5, TNF, CSF2, IL10RA, IL10
39pentoxifylline46 128.7CSF2, CD9, IFNG, IL2, IL10, TNF
40neopterin467.7CSF2, IFNG, CD9, TNF, IL10, IL2
41cycloheximide467.5TNF, FASLG, IFNG, IL2, IL10, CSF2
42genistein46 30 62 3 25 1212.5IL2, CD9, CSF2, CXCL12, TNF, FASLG
43tacrolimus46 52 129.5IL10, IL2, HLA-A, FASLG, HLA-B, TNF
44vegf467.3CXCL12, IFNG, IL2, IL10, TNF, CSF2
45thymidine46 258.1IL2, CXCL12, TNF, FASLG, IFNG, IL10
46tyrosine467.0IL2, HLA-B, HLA-DQB1, HLA-DRB1, CXCL12, IL10RA
47pge2467.0IL2, TNF, FASLG, CCR5, IFNG, IL10
48dexamethasone46 52 30 129.9HLA-B, IL10, IL2, IFNG, CCR5, CXCL12
49cyclosporin a46 30 628.9HLA-B, TNF, CSF2, FASLG, CCR5, IFNG
50rantes466.5HLA-B, CCR5, CXCL12, TNF, IL2, CSF2

GO Terms for genes affiliated with Cytomegalovirus Retinitis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.6HLA-B, HLA-A
2MHC class II protein complexGO:0426139.5HLA-DRB1, HLA-DQB1
3integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.2HLA-B, HLA-DQB1, HLA-A, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:0125079.2HLA-B, HLA-DRB1, HLA-DQB1, HLA-A
5Golgi membraneGO:0001399.0HLA-DRB1, HLA-B, HLA-A, HLA-DQB1
6cell surfaceGO:0099868.6HLA-B, HLA-A, CCR5, TNF
7extracellular regionGO:0055767.7CXCL12, CSF2, IL2, IFNG, FASLG, TNF
8external side of plasma membraneGO:0098977.6FASLG, IFNG, TNF, HLA-DRB1, CD9, CCR5
9integral component of plasma membraneGO:0058877.4CCR5, CCR2, FASLG, TNF, HLA-DRB1, HLA-A
10extracellular spaceGO:0056157.4TNF, CSF2, IL10, IL2, CXCL12, IFNG
11plasma membraneGO:0058867.1TNF, HLA-DQB1, CD9, IL10RA, CCR2, HLA-DRB1

Biological processes related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:00240710.2CCR5, CCR2
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.1HLA-DQB1, HLA-DRB1
3antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00248610.1HLA-A, HLA-B
4humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DRB1, HLA-DQB1
5positive regulation of monocyte chemotaxisGO:09002610.1CCR5, CCR2, CXCL12
6chemokine-mediated signaling pathwayGO:07009810.1CCR5, CCR2, CXCL12
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.0HLA-B, HLA-A
8positive regulation of interleukin-23 productionGO:0327479.9IFNG, CSF2
9chemotaxisGO:0069359.9CXCL12, CCR2, CCR5
10positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IL2, CSF2
11positive regulation of T cell mediated cytotoxicityGO:0019169.8HLA-B, HLA-A
12detection of bacteriumGO:0160459.8HLA-B, HLA-A, HLA-DRB1
13necroptotic signaling pathwayGO:0975279.8TNF, FASLG
14positive regulation of podosome assemblyGO:0718039.7TNF, CSF2
15positive regulation of cytosolic calcium ion concentrationGO:0072049.7IL2, CCR5, CCR2
16positive regulation of MHC class II biosynthetic processGO:0453489.7IL10, IFNG
17positive regulation of isotype switching to IgG isotypesGO:0483049.7IFNG, IL2
18receptor biosynthetic processGO:0328009.6IL10, TNF
19negative regulation of cytokine secretion involved in immune responseGO:0027409.6TNF, IL10
20negative regulation of interferon-gamma productionGO:0326899.5IL10, HLA-DRB1
21positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
22positive regulation of calcidiol 1-monooxygenase activityGO:0605599.4IFNG, TNF
23cell-cell signalingGO:0072679.3FASLG, CCR5, IL2, IL10
24negative regulation of interleukin-6 productionGO:0327159.3TNF, IL10
25positive regulation of chemokine biosynthetic processGO:0450809.3IFNG, TNF
26positive regulation of membrane protein ectodomain proteolysisGO:0510449.3IFNG, TNF
27cellular response to lipopolysaccharideGO:0712229.3CCR5, IFNG, IL10, CSF2
28viral processGO:0160329.2HLA-B, HLA-A, CCR2, CCR5
29positive regulation of osteoclast differentiationGO:0456729.2IFNG, TNF
30response to activityGO:0148239.2IL10, TNF
31extrinsic apoptotic signaling pathwayGO:0971919.2TNF, FASLG, IFNG
32protein import into nucleus, translocationGO:0000609.1IFNG, TNF
33inflammatory responseGO:0069549.0TNF, CCR2, CCR5, IL10
34response to virusGO:0096159.0IFNG, CXCL12, TNF
35negative regulation of growth of symbiont in hostGO:0441309.0TNF, IFNG, IL10
36positive regulation of interferon-gamma productionGO:0327299.0HLA-A, TNF, CCR2, IL2
37positive regulation of cytokine secretionGO:0507158.9IL10, TNF
38interferon-gamma-mediated signaling pathwayGO:0603338.8HLA-B, HLA-A, HLA-DQB1, HLA-DRB1, IFNG
39cytokine-mediated signaling pathwayGO:0192218.4HLA-B, HLA-A, HLA-DQB1, HLA-DRB1, CCR2, IFNG
40immune responseGO:0069557.6CSF2, HLA-B, HLA-A, HLA-DQB1, HLA-DRB1, FASLG

Molecular functions related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:01649310.0CCR2, CCR5
2TAP bindingGO:0469779.8HLA-B, HLA-A
3MHC class II receptor activityGO:0323959.7HLA-DRB1, HLA-DQB1
4chemokine receptor activityGO:0049509.7CCR5, CCR2
5peptide antigen bindingGO:0426059.5HLA-B, HLA-A, HLA-DRB1
6tumor necrosis factor receptor bindingGO:0051649.4FASLG, TNF
7receptor bindingGO:0051029.2CXCL12, FASLG, HLA-A, HLA-B
8growth factor activityGO:0080839.1CSF2, IL10, IL2, CXCL12
9cytokine activityGO:0051257.7CSF2, IL10, IL2, IFNG, FASLG, TNF

Products for genes affiliated with Cytomegalovirus Retinitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
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38MGI
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