MCID: CYT005
MIFTS: 42

Cytomegalovirus Retinitis malady

Summaries for Cytomegalovirus Retinitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that... more...

MalaCards: Cytomegalovirus Retinitis is related to acquired immunodeficiency syndrome and uveitis. An important gene associated with Cytomegalovirus Retinitis is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are Rheumatoid arthritis and Cytokines and Inflammatory Response. The drugs ganciclovir and ganciclovir sodium and the compounds endotoxin and tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related mouse phenotypes are no phenotypic analysis and nervous system.

Aliases & Classifications for Cytomegalovirus Retinitis

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

cytomegalovirus retinitis 42 60


Related Diseases for Cytomegalovirus Retinitis

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17GeneCards, 18GeneDecks
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Diseases related to Cytomegalovirus Retinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1acquired immunodeficiency syndrome31.0IL2, CXCL12, HLA-B, CSF2, CCR5, CCR2
2uveitis30.8IL10, HLA-A, HLA-B, TNF, IFNG, CCR5
3acute leukemia30.4IL2, CXCL12, HDAC9, CSF2
4systemic lupus erythematosus30.3IL2, IL10, IL10RA, HLA-A, HLA-DRB1, HLA-DQB1
5leukemia30.3IL2, CXCL12, CD9, HDAC9, HLA-A, HLA-DRB1
6wegener's granulomatosis30.3CCR5
7optic neuritis30.2IFNB1
8intraocular lymphoma30.1IL10
9hodgkin's lymphoma30.1IL2, HLA-A, HLA-B, CSF2
10herpes zoster29.9CD9
11proliferative diabetic retinopathy29.9CXCL12
12diabetic retinopathy29.9CXCL12
13thymoma29.9IL2
14dermatomyositis29.9HLA-B
15thrombocytopenia29.9IL2, CSF2
16leprosy29.9IL2, HLA-DRB1
17herpes simplex29.9HLA-B, IFNB1, IDO1
18aplastic anemia29.9FASLG, CSF2, IFNG
19encephalitis29.9CD9, HLA-B, IDO1, CCR5
20vasculitis29.9HLA-B, TNF
21tuberculoid leprosy29.9IL10, IFNG
22t-cell leukemia29.9IL2, HDAC9, HLA-B, FASLG
23diabetes mellitus29.9HLA-A, HLA-DRB1, HLA-B, HLA-DQB1, TNF
24myeloma29.9IL2, CXCL12, CD9, HDAC9, HLA-B, FASLG
25pneumonia29.9IL10, CD9, HDAC9, TNF, CSF2, IDO1
26tuberculosis29.9IL2, IL10, CXCL12, CD9, HLA-A, HLA-DRB1
27arthritis29.9IL10, HDAC9, HLA-A, HLA-DRB1, HLA-B, TNF
28rheumatoid arthritis29.9IL2, IL10, IL10RA, CXCL12, HLA-A, HLA-DRB1
29retinitis11.3
30retinal detachment10.6
31retinal disease10.4
32cystoid macular edema10.4
33macular retinal edema10.4
34good syndrome10.3
35central retinal vein occlusion10.3
36lupus erythematosus10.3
37retinal vein occlusion10.3
38choroiditis10.2
39lymphoblastic leukemia10.2
40common variable immunodeficiency10.1
41cataract10.1
42neuritis10.1
43vein disease10.1
44toxoplasmosis10.0CD9
45sjogren's syndrome10.0FASLG
46myocarditis10.0IFNB1
47chagas disease10.0CCR5
48toxic epidermal necrolysis10.0FASLG
49guillain-barre syndrome10.0CCR5
50glomerulonephritis10.0CCR5

Graphical network of the top 20 diseases related to Cytomegalovirus Retinitis:



Diseases related to cytomegalovirus retinitis

Clinical Features for Cytomegalovirus Retinitis

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Drugs & Therapeutics for Cytomegalovirus Retinitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Cytomegalovirus Retinitis

Drug clinical trials:

Search ClinicalTrials for Cytomegalovirus Retinitis

Search NIH Clinical Center for Cytomegalovirus Retinitis

Search CenterWatch for Cytomegalovirus Retinitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Cytomegalovirus Retinitis

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Anatomical Context for Cytomegalovirus Retinitis

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32MalaCards
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MalaCards organs/tissues related to Cytomegalovirus Retinitis:

32
Eye, Retina

Animal Models for Cytomegalovirus Retinitis or affiliated genes

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36MGI
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Publications for Cytomegalovirus Retinitis

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Genetic Variations for Cytomegalovirus Retinitis

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Expression for genes affiliated with Cytomegalovirus Retinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Cytomegalovirus Retinitis

Search GEO for disease gene expression data for Cytomegalovirus Retinitis.

Pathways for genes affiliated with Cytomegalovirus Retinitis

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 55SinoBiological, 52R&D Systems, 4Cell Signaling Technology
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Pathways related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2CSF2
210.1HLA-DRB1
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.9FASLG, IFNG
49.7CCR5, CCR2, CXCL12
59.5IL2, HLA-DRB1, HLA-DQB1
69.5TNF, IFNG, CCR2
7
Immune response Bacterial infections in normal airways
9.5IFNG, TNF, FASLG
89.5TNF, CCR2, IL2
99.4HLA-DRB1, IL2, IFNG
10
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9.4IL10RA, IL2, IFNB1
11
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9.4IL10RA, CCR5, HLA-DQB1, HLA-DRB1
129.4IL2, TNF, IFNG
139.3IL10, HLA-DRB1, HLA-DQB1
149.3IL10RA, TNF, IL10
159.3IFNG, IL2, IL10
16
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9.3CCR5, CCR2, CXCL12, IL10RA, CSF2
17
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9.3CXCL12, IL10RA, CSF2, CCR2, CCR5
18
Immune response IFN alpha/beta signaling pathway
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9.2HLA-B, IFNB1, HLA-A
19
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9.2TNF, FASLG, HLA-DQB1, HLA-A
209.2IFNB1, IFNG, HLA-B
219.2CSF2, IL2, HLA-B, HLA-DQB1
229.1HLA-B, HLA-A, HLA-DQB1, HLA-DRB1
239.1HLA-B, HLA-DRB1, HLA-DQB1, HLA-A
248.9IFNG, IL10, TNF, CSF2
258.9HLA-A, CCR5, HLA-B, HDAC9
26
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8.9IL2, IFNG, CSF2, TNF, FASLG
27
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8.8IFNG, TNF, IL10, IL2
288.8FASLG, IL2, HLA-A, TNF, IFNG
29
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8.8HLA-A, HLA-B, FASLG, IFNG, TNF
308.7IL10, FASLG, IFNG, IDO1, TNF
31
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8.7HLA-DRB1, IFNG, HLA-DQB1, TNF, IL2
328.7IL2, IL10, FASLG, CCR2, CXCL12, IDO1
33
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8.7HLA-DRB1, IL2, IFNG, FASLG, HLA-A, CCR5
34
Development PDGF signaling via STATs and NF-kB
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8.6IL10, IL10RA, TNF, IL2, IFNG
358.6TNF, CSF2, CD9, HLA-DRB1
36
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8.3TNF, CSF2, IFNG, IL10, FASLG, IL2
37
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8.3TNF, CSF2, IL2, IFNG, CCR5, IL10
388.3IFNG, IL10, IFNB1, TNF, IL2
398.3IL10, IL2, IFNG, CSF2, IL10RA, IFNB1
408.1IL10, IL10RA, HLA-DRB1, HLA-DQB1, TNF, IFNB1
418.1IFNG, HLA-DQB1, HLA-B, HLA-A, IL10, IL10RA
42
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8.1IL2, IL10, FASLG, IFNG, TNF, IFNB1
43
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7.9CSF2, CCR5, CCR2, TNF, CXCL12, IL10RA
44
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7.9TNF, IL10, HDAC9, IFNG, HLA-DQB1, HLA-DRB1
45
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7.9CCR2, CCR5, IL10RA, CSF2, FASLG, HDAC9
46
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7.7IFNG, IL2, HLA-A, HLA-DRB1, HLA-B, HLA-DQB1
47
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7.6IFNG, IFNB1, CSF2, TNF, FASLG, HLA-B
48
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7.5IFNB1, IFNG, CCR2, CSF2, HLA-DQB1, HLA-DRB1
49
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7.3IFNG, HLA-A, HLA-DRB1, IFNB1, TNF, FASLG
50
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7.1HLA-A, TNF, FASLG, HLA-DQB1, HLA-B, HLA-DRB1

Compounds for genes affiliated with Cytomegalovirus Retinitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.6FASLG
2tacrolimus44 49 1111.9IFNG, FASLG, IL2
3cyclosporin a44 28 5911.8HLA-A, IFNG, HLA-B
4cycloheximide449.8IFNB1, FASLG, CXCL12
5pentoxifylline44 1110.8CSF2, CD9
6pge2449.7CSF2, HDAC9, IL2
7gm-csf44 2810.5IFNG, IL10, TNF
8mip 1alpha449.2CCR5, CSF2, TNF, IL10
9interferon gamma449.2IFNG, TNF, IL10, IL2
10quinine44 28 2 1112.1IL10, CXCL12, CSF2, IDO1, CCR5
11gold sodium thiomalate449.1IL2, HLA-DRB1, TNF, IFNG
12dexamethasone44 49 28 1112.0IDO1, IFNB1, CXCL12, HDAC9, FASLG
13groalpha449.0IL10, CSF2, TNF, CXCL12, CCR5
14cyclophosphamide44 49 1111.0CXCL12, CSF2, IL2, FASLG, IFNB1
15poly(i-c)449.0TNF, CSF2, IFNB1, IDO1, IFNG
162,5-oligoadenylate449.0IFNB1, TNF, HLA-B, IL2, IDO1
17il-12448.9CSF2, TNF, IFNG, IL2, IL10
18okt3448.9IL2, IFNG, CSF2, TNF, IL10
19glatiramer acetate44 119.8IL10, IL2, IFNG, IFNB1, HLA-DRB1
20rituximab44 49 1110.7IL2, CSF2, IL10, FASLG, TNF, CXCL12
21mdms448.7CCR5, CSF2, CD9, CXCL12, IL10
22natalizumab44 119.7IL10, TNF, IFNB1, IFNG
23ganciclovir44 119.6IFNB1, CD9, FASLG
24imiquimod44 28 59 1111.6IFNB1, IL10, TNF, FASLG, CSF2, IFNG
25ccl344 289.5IFNG, IL10, CXCL12, TNF, CCR5, IFNB1
26herbimycin a44 599.5CSF2, IFNB1, IFNG, TNF, CXCL12, IL2
27simvastatin44 49 59 28 11 2413.4IL10, FASLG, IFNB1, IFNG, CCR5, TNF
28ifn-alpha448.4CSF2, FASLG, IFNB1, IL2, IL10, CXCL12
29ionomycin448.4FASLG, IL10, CSF2, IFNG, IL2, TNF
30ivig448.3CCR5, IFNG, IFNB1, CSF2, TNF, FASLG
31polyinosinic-polycytidylic acid448.3IFNG, IL2, IL10, HLA-B, TNF, IFNB1
32tarc448.3CXCL12, CCR5, IFNG, IFNB1, CSF2, TNF
33ribavirin44 49 1110.3IL2, CCR5, IFNG, IL10, HLA-B, CSF2
34actinomycin d448.2IFNG, CCR5, FASLG, IFNB1, CSF2, TNF
355-aza-2deoxycytidine448.1CXCL12, HLA-B, FASLG, IFNB1, IFNG, HDAC9
36thalidomide44 49 59 1111.1IFNG, IL2, FASLG, HDAC9, IL10, TNF
37il 10448.0IL2, IL10, IL10RA, TNF, CSF2, CCR5
385fluorouracil448.0CSF2, FASLG, IFNG, IFNB1, HLA-A, CXCL12
39polysaccharide448.0HLA-B, CD9, FASLG, CSF2, IFNB1, CXCL12
40calcitriol44 59 11 2410.9IFNG, CSF2, HDAC9, TNF, IL2, IL10
41zidovudine44 118.9CCR5, IFNB1, CD9, IL10, CSF2, CXCL12
42sb 20358044 598.6IL10, TNF, FASLG, IFNG, HDAC9, CXCL12
43genistein44 28 59 2 11 2412.5CD9, IFNB1, CSF2, TNF, FASLG, CXCL12
44neopterin447.5IL10, CD9, TNF, CSF2, IDO1, IFNG
45vegf447.2TNF, CXCL12, IL2, IFNG, IFNB1, CSF2
46rantes447.1IDO1, IFNG, IFNB1, CSF2, TNF, FASLG
47oligonucleotide447.0CD9, FASLG, IDO1, HLA-DQB1, HLA-B, IFNB1
48ly294002446.9IFNB1, TNF, FASLG, HDAC9, CD9, CXCL12
49thymidine44 247.9IDO1, IFNG, IFNB1, CSF2, FASLG, CD9
50tyrosine445.8IDO1, CCR5, CXCL12, FASLG, HLA-DRB1, IFNB1

GO Terms for genes affiliated with Cytomegalovirus Retinitis

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16Gene Ontology
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Cellular components related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.8HLA-A, HLA-B
2integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DQB1, HLA-B, HLA-DRB1, HLA-A
3ER to Golgi transport vesicle membraneGO:0125079.2HLA-DQB1, HLA-B, HLA-DRB1, HLA-A
4external side of plasma membraneGO:0098977.9CXCL12, CD9, HLA-DRB1, FASLG, TNF, IFNG
5extracellular regionGO:0055767.7IFNG, IFNB1, CSF2, TNF, FASLG, CXCL12
6extracellular spaceGO:0056157.5IFNG, IFNB1, CSF2, TNF, FASLG, CXCL12
7integral to plasma membraneGO:0058877.3CCR2, CCR5, TNF, FASLG, HLA-B, HLA-DRB1

Biological processes related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-23 productionGO:03274710.2IFNG, CSF2
2activation of necroptosis by extracellular signalsGO:06055510.1TNF, FASLG
3chemokine-mediated signaling pathwayGO:07009810.1CXCL12, CCR5, CCR2
4immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.1HLA-DQB1, HLA-DRB1
5necrotic cell deathGO:07026510.1TNF, FASLG
6positive regulation of isotype switching to IgG isotypesGO:04830410.1IFNG, IL2
7positive regulation of vitamin D biosynthetic processGO:06055710.1TNF, IFNG
8humoral immune response mediated by circulating immunoglobulinGO:00245510.1HLA-DRB1, HLA-DQB1
9positive regulation of calcidiol 1-monooxygenase activityGO:06055910.0IFNG, TNF
10positive regulation of podosome assemblyGO:07180310.0CSF2, TNF
11positive regulation of monocyte chemotaxisGO:09002610.0CXCL12, CCR2
12positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.0IFNG, IFNB1
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.9HLA-A, HLA-B
14positive regulation of chemokine biosynthetic processGO:0450809.9TNF, IFNG
15positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL10
16receptor biosynthetic processGO:0328009.8TNF, IL10
17positive regulation of interferon-gamma productionGO:0327299.8CCR2, TNF, IL2
18negative regulation of cytokine secretion involved in immune responseGO:0027409.8TNF, IL10
19detection of bacteriumGO:0160459.8HLA-B, HLA-DRB1, HLA-A
20positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IFNG
21negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF, IL10
22cellular response to lipopolysaccharideGO:0712229.5IL10, CSF2, IFNG, CCR5
23humoral immune responseGO:0069599.5IFNG, IFNB1, TNF
24type I interferon-mediated signaling pathwayGO:0603379.5HLA-A, HLA-B, IFNB1
25elevation of cytosolic calcium ion concentrationGO:0072049.4CCR2, CCR5, IL2
26activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3IFNB1, TNF, FASLG
27B cell proliferationGO:0421009.3IL10, IFNB1
28cell-cell signalingGO:0072679.3CCR5, FASLG, IL10, IL2
29response to virusGO:0096159.3IFNG, IFNB1, TNF, CXCL12
30interferon-gamma-mediated signaling pathwayGO:0603339.2IFNG, HLA-DQB1, HLA-B, HLA-DRB1, HLA-A
31inflammatory responseGO:0069548.8CCR2, CCR5, TNF, HDAC9, IL10
32cytokine-mediated signaling pathwayGO:0192218.5CCR2, IFNG, IFNB1, HLA-DQB1, HLA-B, HLA-DRB1
33immune responseGO:0069558.0IL2, CCR2, CCR5, CSF2, FASLG, HLA-DQB1

Molecular functions related to Cytomegalovirus Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.8HLA-DRB1, HLA-DQB1
2C-C chemokine receptor activityGO:0164939.7CCR5, CCR2
3peptide antigen bindingGO:0426059.5HLA-A, HLA-DRB1, HLA-B
4receptor bindingGO:0051029.2FASLG, HLA-B, HLA-A, CXCL12
5growth factor activityGO:0080839.1CSF2, CXCL12, IL10, IL2
6cytokine activityGO:0051257.9IL2, IFNG, IFNB1, CSF2, TNF, FASLG

Products for genes affiliated with Cytomegalovirus Retinitis

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Sources for Cytomegalovirus Retinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet