MCID: DCR003
MIFTS: 40

Dacryoadenitis malady

Eye diseases category

Summaries for Dacryoadenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing glands). more...

MalaCards: Dacryoadenitis is related to sialadenitis and keratoconjunctivitis sicca. An important gene associated with Dacryoadenitis is TGFB1 (transforming growth factor, beta 1), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The compounds pilocarpine and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Dacryoadenitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

dacryoadenitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:950
MeSH34 D003607
NCIt39 C26971
ICD9CM27 375.00, 375.0
ICD1025 H04.0

Related Diseases for Dacryoadenitis

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17GeneCards, 18GeneDecks
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Diseases in the Dacryoadenitis family:

Acute Dacryoadenitis Chronic Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1sialadenitis30.3HSPG2, CD4
2keratoconjunctivitis sicca30.0HSPG2
3sjogren's syndrome30.0AQP5, HSPG2
4hepatitis c29.8HSPG2, CD4
5hepatitis29.8CD4, HSPG2
6acute dacryoadenitis10.6
7chronic dacryoadenitis10.5
8crohn's disease10.2
9keratoconjunctivitis10.2
10wegener's granulomatosis10.1
11churg-strauss syndrome10.1
12conjunctivitis10.1
13mikulicz disease10.0
14infectious mononucleosis10.0
15tuberculosis10.0
16severe combined immunodeficiency10.0IL21
17malaria10.0CD4
18anaplastic large cell lymphoma10.0CD4
19dermatophytosis10.0B4GALNT2
20laryngeal benign neoplasm10.0CD4
21meningoencephalitis10.0CD4
22alopecia10.0CD4
23periodontal disease10.0CD4
24connective tissue disease10.0TGFB1, CD4
25thrombocytopenia10.0CD4
26dry eye syndrome10.0HSPG2
27leishmaniasis10.0CD4
28asthma10.0CD4, AQP5, TGFB1
29eosinophilia10.0CD4, HSPG2
30multiple sclerosis10.0HSPG2, TGFB1, CD4
31hypersensitivity reaction type ii disease10.0HSPG2, CD4, IL21, TGFB1
32orbital periostitis9.9
33acute myeloid leukemia9.9
34systemic lupus erythematosus9.9
35nasal cavity lymphoma9.9
36lyme disease9.9
37reactive arthritis9.9
38herpes zoster9.9
39tonsillitis9.9
40mumps9.9
41acute leukemia9.9
42allergic conjunctivitis9.9
43arthritis9.9
44brucellosis9.9
45chronic conjunctivitis9.9
46dermatitis9.9
47diabetes mellitus9.9
48herpes simplex9.9
49intestinal disease9.9
50keratitis9.9

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to dacryoadenitis

Clinical Features for Dacryoadenitis

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Drugs & Therapeutics for Dacryoadenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dacryoadenitis

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Anatomical Context for Dacryoadenitis

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32MalaCards
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MalaCards organs/tissues related to Dacryoadenitis:

32
Eye, Skin, Bone, Lymph node, Bone marrow, Thyroid, Myeloid, T cells, Tonsil

Animal Models for Dacryoadenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dacryoadenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1HSPG2, B4GALNT2, CD4, XCL1, AQP5, TGFB1
2MP:00053846.5HSPG2, APOF, CTSZ, B4GALNT2, CD4, IL21

Publications for Dacryoadenitis

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50PubMed
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Articles related to Dacryoadenitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis. (23663138)
2013
2
Dacryoadenitis as first presenting feature in systemic lupus erythematosus. (23884982)
2013
3
Acute suppurative bacterial dacryoadenitis: a case series. (23603486)
2013
4
BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the lacrimal fluid. (23433092)
2013
5
Clinical features of IgG4-related dacryoadenitis. (24318531)
2013
6
A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of SjAPgren's syndrome. (23892265)
2013
7
T helper subsets in SjAPgren's syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. (23920005)
2013
8
Deletion of interferon-I^ delays onset and severity of dacryoadenitis in CD25KO mice. (23116218)
2012
9
Bilateral dacryoadenitis. (22416166)
2012
10
Histopathology and immunohistochemical profile in idiopathic dacryoadenitis. (22510006)
2012
11
Tuberculous dacryoadenitis in a child. (21876602)
2011
12
Dacryoadenitis and diffuse orbital inflammation: unusual first presentations of Churg-Strauss syndrome. (21574807)
2011
13
IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis. (21757831)
2011
14
Relationship between chronic sclerosing dacryoadenitis with high level of IgG4 and Castleman disease. (21311653)
2010
15
Dacryoadenitis as a presenting feature of the Churg Strauss syndrome. (19444294)
2010
16
Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. (20505195)
2010
17
Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. (19456259)
2009
18
A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis. (18855098)
2009
19
Tuberculous dacryoadenitis in a Scottish teenager. (19174399)
2009
20
Autoimmune dacryoadenitis and keratoconjunctivitis induced in rabbits by subcutaneous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. (18534818)
2008
21
Dacryoadenitis caused by methicillin-resistant Staphylococcus aureus. (18209643)
2008
22
Dacryoadenitis and orbital myositis associated with lyme disease. (18695120)
2008
23
Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? (17414116)
2007
24
Tubercular dacryoadenitis--a case report and review of literature. (17001891)
2006
25
Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. (15111591)
2004
26
Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. (12792478)
2003
27
Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. (12502944)
2003
28
Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis. (12059880)
2002
29
Dacryoadenitis as the earliest presenting manifestation of systemic Wegener's granulomatosis. (12113573)
2002
30
Tuberculous dacryoadenitis: a rare manifestation of tuberculosis. (12481880)
2002
31
Leakage of aquaporin 5 in the tear of dacryoadenitis mice. (10937550)
2000
32
Brucella melitensis dacryoadenitis: a case report. (11071036)
2000
33
Lymphocytic hypophysitis associated with dacryoadenitis: an autoimmunologically mediated syndrome. (10408464)
1999
34
Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. (9502771)
1998
35
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. (9328136)
1997
36
Pseudomonas dacryoadenitis secondary to a lacrimal gland ductule stone. (9185196)
1997
37
Role of the ICAM-1/LFA-1 pathway during the development of autoimmune dacryoadenitis in an animal model for SjAPgren's syndrome. (9068010)
1996
38
Dacryoadenitis presenting with eyelid retraction. (8532298)
1995
39
Adoptive transfer of experimental autoimmune dacryoadenitis in susceptible and resistant mice. (8370074)
1993
40
Treatment of experimental autoimmune dacryoadenitis with cyclosporin A. (8443987)
1993
41
Wegener's granulomatosis presenting as dacryoadenitis. (1782785)
1991
42
Ectopic lacrimal gland tissue of the orbit and sclerosing dacryoadenitis. (3991115)
1985
43
Clinical and histocytopathological study of chronic dacryoadenitis. (6313486)
1983
44
Dacryoadenitis, conjunctivitis, and facial dermatitis of the mouse. (853714)
1977
45
Ophthalmic lesions and dacryoadenitis: a naturally occurring aspect of sialodacryoadenitis virus infection of the laboratory rat. (198605)
1977
46
Granulomatous dacryoadenitis caused by Schistosoma haematobium. (556933)
1977
47
Report of a case of bilateral caseous tuberculous dacryoadenitis. (5075142)
1972
48
Acute disease of the submaxillary and Harderian glands (sialo-dacryoadenitis) of rats with cytomegaly and no inclusion bodies. (13717762)
1961
49
Traumatic Periostitis of Orbit: Further Note on Case shown November 13, 1931, as one of Dacryoadenitis. (19988799)
1932
50
Acute Dacryoadenitis Caused by Focal Infection. (16692717)
1925

Genetic Variations for Dacryoadenitis

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Expression for genes affiliated with Dacryoadenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dacryoadenitis

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Pathways for genes affiliated with Dacryoadenitis

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52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Dacryoadenitis

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44Novoseek, 28IUPHAR, 11DrugBank, 2BitterDB
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Compounds related to Dacryoadenitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pilocarpine44 28 1111.9AQP5, HSPG2
2aristolochic acid44 210.6TGFB1, HSPG2
3rantes448.9TGFB1, XCL1, IL21, CD4

GO Terms for genes affiliated with Dacryoadenitis

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16Gene Ontology
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Cellular components related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:0059029.9TGFB1, AQP5
2extracellular spaceGO:0056158.4TGFB1, XCL1, IL21, CTSZ, HSPG2

Biological processes related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0TGFB1, IL21
2chondrocyte differentiationGO:0020629.9TGFB1, HSPG2
3response to cholesterolGO:0707239.8TGFB1, PMVK
4negative regulation of cell-cell adhesionGO:0224089.7TGFB1, B4GALNT2
5positive regulation of interleukin-10 productionGO:0327339.5IL21, XCL1
6release of sequestered calcium ion into cytosolGO:0512099.1XCR1, XCL1

Products for genes affiliated with Dacryoadenitis

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Sources for Dacryoadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet