MCID: DCR003
MIFTS: 35

Dacryoadenitis malady

Eye diseases category

Summaries for Dacryoadenitis

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Wikipedia:63 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing glands). more...

MalaCards based summary: Dacryoadenitis is related to systemic lupus erythematosus and acute dacryoadenitis. An important gene associated with Dacryoadenitis is TGFB1 (transforming growth factor, beta 1), and among its related pathways are Leishmaniasis and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds aristolochic acid and ang ii have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and b cells, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Dacryoadenitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 38NCIt, 60UMLS, 33MeSH, 25ICD10
See all sources

Dacryoadenitis, Aliases & Descriptions:

Name: Dacryoadenitis 9 11 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:950
ICD9CM27 375.0, 375.00
NCIt38 C26971
MeSH33 D003607
ICD1025 H04.0

Related Diseases for Dacryoadenitis

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Diseases in the Dacryoadenitis family:

Acute Dacryoadenitis Chronic Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus29.5IL21, HSPG2
2acute dacryoadenitis10.5
3connective tissue disease10.4TGFB1
4sialadenitis10.4
5chronic dacryoadenitis10.3
6crohn's disease10.3
7mikulicz disease10.3
8keratoconjunctivitis10.3
9cystic fibrosis10.2HSPG2
10churg-strauss syndrome10.2
11conjunctivitis10.2
12lymphocytic hypophysitis10.2
13hypersensitivity reaction type ii disease10.1TGFB1, HSPG2
14pancreatitis10.1HSPG2, TGFB1
15systemic scleroderma10.1TGFB1, HSPG2
16acute erythroid leukemia10.1TGFB1, HSPG2
17keratitis10.1
18b-cell lymphomas10.1
19marginal zone b-cell lymphoma10.1
20keratoconjunctivitis sicca10.1
21sjogren's syndrome10.1
22tuberculosis10.1
23acanthamoeba keratitis10.1
24cork-handlers' disease10.1HSPG2, TGFB1
25pneumonia10.1TGFB1, HSPG2
26hyperglycemia10.1TGFB1, HSPG2
27multiple sclerosis, disease progression, modifier of10.0TGFB1, HSPG2
28obesity10.0
29hepatitis10.0
30leukemia10.0
31hepatitis c10.0
32lyme disease10.0
33herpes zoster10.0
34tonsillitis10.0
35mumps10.0
36allergic conjunctivitis10.0
37brucellosis10.0
38dermatitis10.0
39herpes simplex10.0
40lupus erythematosus10.0
41myeloid leukemia10.0
42myositis10.0
43periostitis10.0
44thyroiditis10.0
45uveitis10.0
46anterior uveitis10.0
47herpes zoster ophthalmicus10.0
48riedel thyroiditis10.0
49nodal marginal zone b-cell lymphoma10.0
50osteoarthritis9.9IL21, TGFB1

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to dacryoadenitis

Symptoms for Dacryoadenitis

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Drugs & Therapeutics for Dacryoadenitis

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Drug clinical trials:

Search ClinicalTrials for Dacryoadenitis

Search NIH Clinical Center for Dacryoadenitis

Genetic Tests for Dacryoadenitis

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Anatomical Context for Dacryoadenitis

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MalaCards organs/tissues related to Dacryoadenitis:

31
Eye, T cells, B cells, Bone marrow, Bone, Lymph node, Thyroid, Salivary gland, Skin, Tonsil, Myeloid

Animal Models for Dacryoadenitis or affiliated genes

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MGI Mouse Phenotypes related to Dacryoadenitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3TGFB1, APOF, HSPG2
2MP:00053768.1IL21, TGFB1, APOF, HSPG2

Publications for Dacryoadenitis

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Articles related to Dacryoadenitis:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Contact Lens-Related Acanthamoeba Keratitis and Accompanying Dacryoadenitis. (25603441)
2015
2
Reversible lacrimal gland-protective regulatory T cell dysfunction underlies male-specific autoimmune dacryoadenitis in the nonobese diabetic mouse model of SjAPgren syndrome. (25581706)
2015
3
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
4
Idiopathic dacryoadenitis mimicking a primary intraocular tumour in a young girl. (24533840)
2014
5
Clinical Recognition and Management of an Atypical Dacryoadenitis. (25469005)
2014
6
Granulomatous dacryoadenitis in regional enteritis (crohn disease). (25036879)
2014
7
NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis. (23663138)
2013
8
A case of IgG4-related dacryoadenitis that regressed without systemic steroid administration. (23801134)
2013
9
Dacryoadenitis as first presenting feature in systemic lupus erythematosus. (23884982)
2013
10
Acute suppurative bacterial dacryoadenitis: a case series. (23603486)
2013
11
BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the lacrimal fluid. (23433092)
2013
12
Clinical features of IgG4-related dacryoadenitis. (24318531)
2013
13
Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. (22753386)
2012
14
Deletion of interferon-I^ delays onset and severity of dacryoadenitis in CD25KO mice. (23116218)
2012
15
Simultaneous occurrence of IgG4-related chronic sclerosing dacryoadenitis and chronic sclerosing sialadenitis associated with lymph node involvement and Warthin's tumor. (19117975)
2011
16
Tuberculous dacryoadenitis in a child. (21876602)
2011
17
Severe anterior uveitis associated with idiopathic dacryoadenitis in diabetes mellitus patient. (21654891)
2011
18
Relationship between chronic sclerosing dacryoadenitis with high level of IgG4 and Castleman disease. (21311653)
2010
19
Dacryoadenitis, an extra-intestinal manifestation of Crohn's disease. (20686473)
2010
20
IgG4-related dacryoadenitis. (20141856)
2010
21
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
22
Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. (19456259)
2009
23
A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis. (18855098)
2009
24
Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. (18580683)
2008
25
Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? (17414116)
2007
26
Dacryoadenitis associated with Acanthamoeba keratitis. (16966617)
2006
27
Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. (15985164)
2005
28
Intralesional steroid injection for management of acute idiopathic dacryoadenitis: a preliminary result. (15778669)
2005
29
Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. (12792478)
2003
30
Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis. (12059880)
2002
31
Leakage of aquaporin 5 in the tear of dacryoadenitis mice. (10937550)
2000
32
Localized orbital inflammation: a case of dacryoadenitis. (10772228)
2000
33
Chronic dacryoadenitis misdiagnosed as eyelid edema and allergic conjunctivitis. (10340792)
1999
34
Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. (9502771)
1998
35
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. (9328136)
1997
36
Role of the ICAM-1/LFA-1 pathway during the development of autoimmune dacryoadenitis in an animal model for SjAPgren's syndrome. (9068010)
1996
37
Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen. (1582807)
1992
38
Wegener's granulomatosis presenting as dacryoadenitis. (1782785)
1991
39
Eosinophilic granulomatous dacryoadenitis causing bilateral keratoconjunctivitis sicca in a horse. (2731512)
1989
40
Acute suppurative dacryoadenitis. (3503190)
1987
41
Ectopic lacrimal gland tissue of the orbit and sclerosing dacryoadenitis. (3991115)
1985
42
Harderian gland dacryoadenitis in rats resulting from orbital bleeding. (513634)
1979
43
Dacryoadenitis, conjunctivitis, and facial dermatitis of the mouse. (853714)
1977
44
Ophthalmic lesions and dacryoadenitis: a naturally occurring aspect of sialodacryoadenitis virus infection of the laboratory rat. (198605)
1977
45
Trachomatous acute palpebral dacryoadenitis. (6043485)
1967
46
Dacryoadenitis in the Sprague-Dawley rat. (13955749)
1963
47
A CASE OF ACUTE DACRYOADENITIS. (20321761)
1940
48
ACUTE DACRYOADENITIS DUE TO THE MORAX-AXENFELD DIPLOBACILLUS. (18169461)
1937
49
Traumatic Periostitis of Orbit: Further Note on Case shown November 13, 1931, as one of Dacryoadenitis. (19988799)
1932
50
A Case of Acute Suppurative Dacryoadenitis. (16692254)
1912

Variations for Dacryoadenitis

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Expression for genes affiliated with Dacryoadenitis

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Search GEO for disease gene expression data for Dacryoadenitis.

Pathways for genes affiliated with Dacryoadenitis

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Compounds for genes affiliated with Dacryoadenitis

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Compounds related to Dacryoadenitis according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1aristolochic acid43 210.7TGFB1, HSPG2
2ang ii439.6TGFB1, HSPG2
3neomycin439.6TGFB1, HSPG2
4losartan43 49 28 1212.6HSPG2, TGFB1
5kainate43 2810.6TGFB1, HSPG2
6verapamil43 28 49 24 1213.5TGFB1, HSPG2
7nifedipine43 28 49 1212.5HSPG2, TGFB1
8choline43 24 1211.5TGFB1, HSPG2
9dmso439.4TGFB1, HSPG2
10indomethacin43 28 59 1212.4TGFB1, HSPG2
11aspirin43 49 28 2412.3HSPG2, TGFB1
12rantes439.2IL21, TGFB1

GO Terms for genes affiliated with Dacryoadenitis

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Cellular components related to Dacryoadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.3TGFB1, HSPG2
2extracellular spaceGO:00056158.6IL21, TGFB1, HSPG2
3extracellular regionGO:00055768.6TGFB1, APOF, HSPG2

Biological processes related to Dacryoadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:00707239.4TGFB1, PMVK
2chondrocyte differentiationGO:00020629.4TGFB1, HSPG2
3positive regulation of interleukin-17 productionGO:00327409.2IL21, TGFB1

Products for genes affiliated with Dacryoadenitis

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Sources for Dacryoadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet