MCID: DCR003
MIFTS: 40

Dacryoadenitis malady

Eye diseases category

Summaries for Dacryoadenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing glands). more...

MalaCards: Dacryoadenitis is related to sialadenitis and keratoconjunctivitis sicca. An important gene associated with Dacryoadenitis is TGFB1 (transforming growth factor, beta 1), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The compounds pilocarpine and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Dacryoadenitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

dacryoadenitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:950
MeSH34 D003607
NCIt39 C26971
ICD9CM27 375.00, 375.0
ICD1025 H04.0

Related Diseases for Dacryoadenitis

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17GeneCards, 18GeneDecks
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Diseases in the Dacryoadenitis family:

Acute Dacryoadenitis Chronic Dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1sialadenitis30.3HSPG2, CD4
2keratoconjunctivitis sicca30.0HSPG2
3sjogren's syndrome30.0AQP5, HSPG2
4hepatitis c29.8HSPG2, CD4
5hepatitis29.8CD4, HSPG2
6acute dacryoadenitis10.6
7chronic dacryoadenitis10.5
8crohn's disease10.2
9keratoconjunctivitis10.2
10wegener's granulomatosis10.1
11churg-strauss syndrome10.1
12conjunctivitis10.1
13mikulicz disease10.0
14infectious mononucleosis10.0
15tuberculosis10.0
16severe combined immunodeficiency10.0IL21
17malaria10.0CD4
18anaplastic large cell lymphoma10.0CD4
19dermatophytosis10.0B4GALNT2
20laryngeal benign neoplasm10.0CD4
21meningoencephalitis10.0CD4
22alopecia10.0CD4
23periodontal disease10.0CD4
24connective tissue disease10.0TGFB1, CD4
25thrombocytopenia10.0CD4
26dry eye syndrome10.0HSPG2
27leishmaniasis10.0CD4
28asthma10.0CD4, AQP5, TGFB1
29eosinophilia10.0CD4, HSPG2
30multiple sclerosis10.0HSPG2, TGFB1, CD4
31hypersensitivity reaction type ii disease10.0HSPG2, CD4, IL21, TGFB1
32orbital periostitis9.9
33acute myeloid leukemia9.9
34systemic lupus erythematosus9.9
35nasal cavity lymphoma9.9
36lyme disease9.9
37reactive arthritis9.9
38herpes zoster9.9
39tonsillitis9.9
40mumps9.9
41acute leukemia9.9
42allergic conjunctivitis9.9
43arthritis9.9
44brucellosis9.9
45chronic conjunctivitis9.9
46dermatitis9.9
47diabetes mellitus9.9
48herpes simplex9.9
49intestinal disease9.9
50keratitis9.9

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to dacryoadenitis

Clinical Features for Dacryoadenitis

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Drugs & Therapeutics for Dacryoadenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dacryoadenitis

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Anatomical Context for Dacryoadenitis

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32MalaCards
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MalaCards organs/tissues related to Dacryoadenitis:

32
Eye, Bone marrow, Bone, Lymph node, Thyroid, Skin, Tonsil, Myeloid, T cells

Animal Models for Dacryoadenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dacryoadenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1B4GALNT2, CD4, XCL1, AQP5, TGFB1, HSPG2
2MP:00053846.5TGFB1, HSPG2, APOF, CTSZ, B4GALNT2, CD4

Publications for Dacryoadenitis

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50PubMed
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Articles related to Dacryoadenitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice. (24389165)
2014
2
A case of IgG4-related dacryoadenitis that regressed without systemic steroid administration. (23801134)
2013
3
Acute suppurative bacterial dacryoadenitis: a case series. (23603486)
2013
4
Spontaneous regression of IgG4-related dacryoadenitis. (22886524)
2013
5
Tuberculous dacryoadenitis unveils HIV infection. (24093205)
2013
6
Churg-Strauss syndrome concomitant with chronic symmetrical dacryoadenitis suggesting Mikulicz's disease. (22975568)
2012
7
Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. (22333667)
2012
8
Sequential right then left acute dacryoadenitis in Crohn's disease. (23047994)
2012
9
Simultaneous occurrence of IgG4-related chronic sclerosing dacryoadenitis and chronic sclerosing sialadenitis associated with lymph node involvement and Warthin's tumor. (19117975)
2011
10
Tuberculous dacryoadenitis in a child. (21876602)
2011
11
Na(+)/K(+)-ATPase in the lacrimal glands of rabbits and its changes during induced autoimmune dacryoadenitis. (21921989)
2011
12
Ultrasound findings in horses with severe eyelid swelling, and recognition of acute dacryoadenitis: 10 cases (2004-2010). (21366823)
2011
13
Dacryoadenitis, an extra-intestinal manifestation of Crohn's disease. (20686473)
2010
14
IgG4-related dacryoadenitis. (20141856)
2010
15
Expression of interleukin-17 in autoimmune dacryoadenitis in MRL/lpr mice. (20858106)
2010
16
IgG4-positive dacryoadenitis and KA1ttner submandibular sclerosing inflammatory tumor. (20625062)
2010
17
Acute dacryoadenitis in Crohn's disease. (22767655)
2010
18
Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. (20566743)
2010
19
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
20
Bilateral dacryoadenitis: a new addition to the spectrum of reactive arthritis? (19300169)
2009
21
Lymphocytic hypophysitis with dacryoadenitis in a male patient: non-invasive diagnosis and high-dose methylprednisolone pulse therapy. (20038929)
2009
22
Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. (18580683)
2008
23
Complication of IgG4-related chronic sclerosing dacryoadenitis by lymphoma. (18695125)
2008
24
Palatal fistula: a complication of primary tuberculous dacryoadenitis. (18458012)
2008
25
Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice. (18055812)
2007
26
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. (17823290)
2007
27
Dacryoadenitis associated with Acanthamoeba keratitis. (16966617)
2006
28
Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human SjAPgren's syndrome. (17082658)
2006
29
Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. (15985164)
2005
30
Herpes simplex virus dacryoadenitis in an immunocompromised patient. (12796273)
2003
31
A case of acute dacryoadenitis associated with herpes zoster ophthalmicus. (12586188)
2003
32
Epstein-Barr virus dacryoadenitis as a complication of bone marrow transplant in a child with combined immunodeficiency. (11827022)
2001
33
Localized orbital inflammation: a case of dacryoadenitis. (10772228)
2000
34
Epstein-Barr virus dacryoadenitis. (10704555)
2000
35
Chronic dacryoadenitis misdiagnosed as eyelid edema and allergic conjunctivitis. (10340792)
1999
36
Bilateral dacryoadenitis associated with brucellosis. (10406164)
1999
37
Histologic examination of the NOD-mouse lacrimal glands, a potential model for idiopathic autoimmune dacryoadenitis in Sjogren's syndrome. (8699811)
1996
38
Infectious mononucleosis presenting with dacryoadenitis. (8637686)
1996
39
Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen. (1582807)
1992
40
Eosinophilic granulomatous dacryoadenitis causing bilateral keratoconjunctivitis sicca in a horse. (2731512)
1989
41
Acute suppurative dacryoadenitis. (3503190)
1987
42
Experimental autoimmune dacryoadenitis. II. Harderian gland disease in the rat. (8591908)
1987
43
Abduction deficit secondary to presumed bacterial dacryoadenitis. (3741233)
1986
44
Acute suppurative dacryoadenitis caused by a cysticercus cellulosa. (7097460)
1982
45
Harderian gland dacryoadenitis in rats resulting from orbital bleeding. (513634)
1979
46
Dacryoadenitis, conjunctivitis, and facial dermatitis of the mouse. (853714)
1977
47
Acute suppurative dacryoadenitis as a sequel to mumps. (13507773)
1958
48
A CASE OF ACUTE DACRYOADENITIS. (20321761)
1940
49
ACUTE DACRYOADENITIS DUE TO THE MORAX-AXENFELD DIPLOBACILLUS. (18169461)
1937
50
A Case of Acute Suppurative Dacryoadenitis. (16692254)
1912

Genetic Variations for Dacryoadenitis

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Expression for genes affiliated with Dacryoadenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dacryoadenitis

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Pathways for genes affiliated with Dacryoadenitis

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52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Dacryoadenitis

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44Novoseek, 28IUPHAR, 11DrugBank, 2BitterDB
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Compounds related to Dacryoadenitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pilocarpine44 28 1111.9AQP5, HSPG2
2aristolochic acid44 210.6TGFB1, HSPG2
3rantes448.9TGFB1, XCL1, IL21, CD4

GO Terms for genes affiliated with Dacryoadenitis

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16Gene Ontology
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Cellular components related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:0059029.9TGFB1, AQP5
2extracellular spaceGO:0056158.4TGFB1, XCL1, IL21, CTSZ, HSPG2

Biological processes related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0TGFB1, IL21
2chondrocyte differentiationGO:0020629.9TGFB1, HSPG2
3response to cholesterolGO:0707239.8TGFB1, PMVK
4negative regulation of cell-cell adhesionGO:0224089.7TGFB1, B4GALNT2
5positive regulation of interleukin-10 productionGO:0327339.5IL21, XCL1
6release of sequestered calcium ion into cytosolGO:0512099.1XCR1, XCL1

Products for genes affiliated with Dacryoadenitis

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Sources for Dacryoadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet