MCID: DCR003
MIFTS: 34

Dacryoadenitis malady

Eye category

Summaries for Dacryoadenitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing glands). more...

MalaCards: Dacryoadenitis is related to sialadenitis and keratoconjunctivitis sicca. An important gene associated with Dacryoadenitis is TGFB1 (transforming growth factor, beta 1), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. The compounds pilocarpine and aristolochic acid have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and cellular.

Aliases & Classifications for Dacryoadenitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 27ICD9CM, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

dacryoadenitis 8 10 45 61


External Ids:

Disease Ontology8 DOID:950
MeSH35 D003607
NCIt40 C26971
ICD9CM27 375.00, 375.0
ICD1025 H04.0

Related Diseases for Dacryoadenitis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dacryoadenitis family:

acute dacryoadenitis chronic dacryoadenitis

Diseases related to Dacryoadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1sialadenitis30.4CD4, HSPG2
2keratoconjunctivitis sicca30.1HSPG2
3sjogren's syndrome30.1AQP5, HSPG2
4acute dacryoadenitis10.6
5chronic dacryoadenitis10.5
6mikulicz disease10.2
7churg-strauss syndrome10.2
8lymphocytic hypophysitis10.2
9wegener's granulomatosis10.1
10infectious mononucleosis10.1
11n syndrome10.1
12tuberculosis10.1
13severe combined immunodeficiency10.0IL21
14malaria10.0CD4
15anaplastic large cell lymphoma10.0CD4
16dermatophytosis10.0B4GALNT2
17laryngeal carcinoma10.0CD4
18meningoencephalitis10.0CD4
19alopecia10.0CD4
20periodontal disease10.0CD4
21connective tissue disease10.0CD4, TGFB1
22dry eye syndrome10.0HSPG2
23leishmaniasis10.0CD4
24thrombocytopenia10.0CD4
25asthma10.0CD4, AQP5, TGFB1
26eosinophilia10.0CD4, HSPG2
27hepatitis c10.0CD4, HSPG2
28hepatitis10.0CD4, HSPG2
29multiple sclerosis10.0HSPG2, CD4, TGFB1
30hypersensitivity reaction type ii disease10.0HSPG2, CD4, IL21, TGFB1
31crohn's disease9.9
32trachoma9.9
33acute myeloid leukemia9.9
34systemic lupus erythematosus9.9
35nasal cavity lymphoma9.9
36lyme disease9.9
37reactive arthritis9.9
38hepatitis d9.9
39herpes zoster9.9
40tonsillitis9.9
41mumps9.9
42acute leukemia9.9
43hepatitis a9.9
44allergic conjunctivitis9.9
45arthritis9.9
46thyroiditis9.9
47uveitis9.9
48anterior uveitis9.9
49castleman's disease9.9
50herpes zoster ophthalmicus9.9

Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to dacryoadenitis

Clinical Features for Dacryoadenitis

Drugs & Therapeutics for Dacryoadenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Dacryoadenitis

Drug clinical trials:

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Search NIH Clinical Center for Dacryoadenitis

Search CenterWatch for Dacryoadenitis

Genetic Tests for Dacryoadenitis

Anatomical Context for Dacryoadenitis

Animal Models for Dacryoadenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Dacryoadenitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.1B4GALNT2, CD4, XCL1, AQP5, TGFB1, HSPG2
2MP:00053846.5TGFB1, HSPG2, APOF, CTSZ, B4GALNT2, CD4

Publications for Dacryoadenitis

Sources:
51PubMed
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Articles related to Dacryoadenitis:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice. (24389165)
2014
2
Acute suppurative bacterial dacryoadenitis: a case series. (23603486)
2013
3
BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the lacrimal fluid. (23433092)
2013
4
Deletion of interferon-I^ delays onset and severity of dacryoadenitis in CD25KO mice. (23116218)
2012
5
Bilateral dacryoadenitis. (22416166)
2012
6
Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. (22333667)
2012
7
Sequential right then left acute dacryoadenitis in Crohn's disease. (23047994)
2012
8
Tuberculous dacryoadenitis in a child. (21876602)
2011
9
Na(+)/K(+)-ATPase in the lacrimal glands of rabbits and its changes during induced autoimmune dacryoadenitis. (21921989)
2011
10
Ultrasound findings in horses with severe eyelid swelling, and recognition of acute dacryoadenitis: 10 cases (2004-2010). (21366823)
2011
11
Relationship between chronic sclerosing dacryoadenitis with high level of IgG4 and Castleman disease. (21311653)
2010
12
IgG4-related dacryoadenitis. (20141856)
2010
13
IgG4-positive dacryoadenitis and KA1ttner submandibular sclerosing inflammatory tumor. (20625062)
2010
14
Acute dacryoadenitis in Crohn's disease. (22767655)
2010
15
Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. (19456259)
2009
16
Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. (18580683)
2008
17
Autoimmune dacryoadenitis and keratoconjunctivitis induced in rabbits by subcutaneous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. (18534818)
2008
18
Dacryoadenitis caused by methicillin-resistant Staphylococcus aureus. (18209643)
2008
19
Complication of IgG4-related chronic sclerosing dacryoadenitis by lymphoma. (18695125)
2008
20
Palatal fistula: a complication of primary tuberculous dacryoadenitis. (18458012)
2008
21
Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? (17414116)
2007
22
Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. (17823290)
2007
23
Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human SjAPgren's syndrome. (17082658)
2006
24
Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. (15985164)
2005
25
Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. (15111591)
2004
26
Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. (12502944)
2003
27
A case of acute dacryoadenitis associated with herpes zoster ophthalmicus. (12586188)
2003
28
Tuberculous dacryoadenitis: a rare manifestation of tuberculosis. (12481880)
2002
29
Brucella melitensis dacryoadenitis: a case report. (11071036)
2000
30
Bilateral dacryoadenitis associated with brucellosis. (10406164)
1999
31
Lymphocytic hypophysitis associated with dacryoadenitis: an autoimmunologically mediated syndrome. (10408464)
1999
32
Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. (9502771)
1998
33
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. (9328136)
1997
34
Histologic examination of the NOD-mouse lacrimal glands, a potential model for idiopathic autoimmune dacryoadenitis in Sjogren's syndrome. (8699811)
1996
35
Dacryoadenitis presenting with eyelid retraction. (8532298)
1995
36
Treatment of experimental autoimmune dacryoadenitis with cyclosporin A. (8443987)
1993
37
Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen. (1582807)
1992
38
Eosinophilic granulomatous dacryoadenitis causing bilateral keratoconjunctivitis sicca in a horse. (2731512)
1989
39
Acute suppurative dacryoadenitis. (3503190)
1987
40
Ectopic lacrimal gland tissue of the orbit and sclerosing dacryoadenitis. (3991115)
1985
41
Acute suppurative dacryoadenitis caused by a cysticercus cellulosa. (7097460)
1982
42
Harderian gland dacryoadenitis in rats resulting from orbital bleeding. (513634)
1979
43
Dacryoadenitis, conjunctivitis, and facial dermatitis of the mouse. (853714)
1977
44
Granulomatous dacryoadenitis caused by Schistosoma haematobium. (556933)
1977
45
Report of a case of bilateral caseous tuberculous dacryoadenitis. (5075142)
1972
46
Acute disease of the submaxillary and Harderian glands (sialo-dacryoadenitis) of rats with cytomegaly and no inclusion bodies. (13717762)
1961
47
A CASE OF ACUTE DACRYOADENITIS. (20321761)
1940
48
ACUTE DACRYOADENITIS DUE TO THE MORAX-AXENFELD DIPLOBACILLUS. (18169461)
1937
49
Traumatic Periostitis of Orbit: Further Note on Case shown November 13, 1931, as one of Dacryoadenitis. (19988799)
1932
50
Acute Dacryoadenitis Caused by Focal Infection. (16692717)
1925

Genetic Variations for Dacryoadenitis

Expression for genes affiliated with Dacryoadenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dacryoadenitis

Search GEO for disease gene expression data for Dacryoadenitis.

Pathways for genes affiliated with Dacryoadenitis

Sources:
53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Dacryoadenitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 2BitterDB
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Compounds related to Dacryoadenitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pilocarpine45 29 1111.9AQP5, HSPG2
2aristolochic acid45 210.6TGFB1, HSPG2
3rantes458.9TGFB1, XCL1, IL21, CD4

GO Terms for genes affiliated with Dacryoadenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microvillusGO:0059029.9TGFB1, AQP5
2extracellular spaceGO:0056158.4TGFB1, XCL1, IL21, CTSZ, HSPG2

Biological processes related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0TGFB1, IL21
2chondrocyte differentiationGO:0020629.9TGFB1, HSPG2
3response to cholesterolGO:0707239.8TGFB1, PMVK
4negative regulation of cell-cell adhesionGO:0224089.7TGFB1, B4GALNT2
5positive regulation of interleukin-10 productionGO:0327339.5IL21, XCL1
6release of sequestered calcium ion into cytosolGO:0512099.1XCR1, XCL1

Products for genes affiliated with Dacryoadenitis

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Sources for Dacryoadenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet