MCID: DCR003
MIFTS: 41

Dacryoadenitis malady

Eye diseases category

Summaries for Dacryoadenitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Dacryoadenitis is inflammation of the lacrimal glands (the tear-producing glands). more...

MalaCards: Dacryoadenitis is related to systemic lupus erythematosus and acute dacryoadenitis. An important gene associated with Dacryoadenitis is TGFB1 (transforming growth factor, beta 1), and among its related pathways are Leishmaniasis and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds aristolochic acid and ang ii have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Dacryoadenitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

dacryoadenitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:950
MeSH36 D003607
ICD9CM28 375.0, 375.00
NCIt41 C26971
ICD1026 H04.0

Related Diseases for Dacryoadenitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Dacryoadenitis:



Diseases related to dacryoadenitis

Symptoms for Dacryoadenitis

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Drugs & Therapeutics for Dacryoadenitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dacryoadenitis

Search CenterWatch for Dacryoadenitis

Genetic Tests for Dacryoadenitis

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Anatomical Context for Dacryoadenitis

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34MalaCards
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MalaCards organs/tissues related to Dacryoadenitis:

34
Eye, Bone marrow, Bone, Lymph node, Thyroid, Skin, Tonsil, Myeloid, T cells

Animal Models for Dacryoadenitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dacryoadenitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3TGFB1, APOF, HSPG2
2MP:00053768.1IL21, TGFB1, APOF, HSPG2

Publications for Dacryoadenitis

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53PubMed
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Articles related to Dacryoadenitis:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
NK/T-cell lymphoma of the nasal cavity causing contralateral dacryoadenitis. (23663138)
2013
2
A case of IgG4-related dacryoadenitis that regressed without systemic steroid administration. (23801134)
2013
3
Dacryoadenitis as first presenting feature in systemic lupus erythematosus. (23884982)
2013
4
Acute suppurative bacterial dacryoadenitis: a case series. (23603486)
2013
5
BXSB/MpJ-Yaa mice develop autoimmune dacryoadenitis with the appearance of inflammatory cell marker messenger RNAs in the lacrimal fluid. (23433092)
2013
6
Clinical features of IgG4-related dacryoadenitis. (24318531)
2013
7
Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. (22753386)
2012
8
Deletion of interferon-I^ delays onset and severity of dacryoadenitis in CD25KO mice. (23116218)
2012
9
Simultaneous occurrence of IgG4-related chronic sclerosing dacryoadenitis and chronic sclerosing sialadenitis associated with lymph node involvement and Warthin's tumor. (19117975)
2011
10
Tuberculous dacryoadenitis in a child. (21876602)
2011
11
Severe anterior uveitis associated with idiopathic dacryoadenitis in diabetes mellitus patient. (21654891)
2011
12
Na(+)/K(+)-ATPase in the lacrimal glands of rabbits and its changes during induced autoimmune dacryoadenitis. (21921989)
2011
13
Relationship between chronic sclerosing dacryoadenitis with high level of IgG4 and Castleman disease. (21311653)
2010
14
Dacryoadenitis, an extra-intestinal manifestation of Crohn's disease. (20686473)
2010
15
IgG4-related dacryoadenitis. (20141856)
2010
16
Clinical characterization and immunopathologic features of sclerosing dacryoadenitis and riedel thyroiditis. (21149794)
2010
17
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
18
Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. (19456259)
2009
19
A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis. (18855098)
2009
20
Bilateral dacryoadenitis: a new addition to the spectrum of reactive arthritis? (19300169)
2009
21
Lymphocytic hypophysitis with dacryoadenitis in a male patient: non-invasive diagnosis and high-dose methylprednisolone pulse therapy. (20038929)
2009
22
Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. (18580683)
2008
23
Chronic sclerosing dacryoadenitis: part of the spectrum of IgG4-related Sclerosing disease? (17414116)
2007
24
Dacryoadenitis associated with Acanthamoeba keratitis. (16966617)
2006
25
Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. (15985164)
2005
26
Intralesional steroid injection for management of acute idiopathic dacryoadenitis: a preliminary result. (15778669)
2005
27
Dacryoadenitis associated with subcutaneous Sweet's syndrome in a patient with acute myeloid leukemia. (15764119)
2005
28
Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. (12792478)
2003
29
Acute infectious mononucleosis presenting with dacryoadenitis and tonsillitis. (12059880)
2002
30
Leakage of aquaporin 5 in the tear of dacryoadenitis mice. (10937550)
2000
31
Localized orbital inflammation: a case of dacryoadenitis. (10772228)
2000
32
Chronic dacryoadenitis misdiagnosed as eyelid edema and allergic conjunctivitis. (10340792)
1999
33
Bilateral dacryoadenitis associated with brucellosis. (10406164)
1999
34
Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. (9502771)
1998
35
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid. (9328136)
1997
36
Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen. (1582807)
1992
37
Wegener's granulomatosis presenting as dacryoadenitis. (1782785)
1991
38
Eosinophilic granulomatous dacryoadenitis causing bilateral keratoconjunctivitis sicca in a horse. (2731512)
1989
39
Acute suppurative dacryoadenitis. (3503190)
1987
40
Experimental autoimmune dacryoadenitis. I. Lacrimal gland disease in the rat. (8591907)
1987
41
Experimental autoimmune dacryoadenitis. II. Harderian gland disease in the rat. (8591908)
1987
42
Ectopic lacrimal gland tissue of the orbit and sclerosing dacryoadenitis. (3991115)
1985
43
Harderian gland dacryoadenitis in rats resulting from orbital bleeding. (513634)
1979
44
Dacryoadenitis, conjunctivitis, and facial dermatitis of the mouse. (853714)
1977
45
Ophthalmic lesions and dacryoadenitis: a naturally occurring aspect of sialodacryoadenitis virus infection of the laboratory rat. (198605)
1977
46
Dacryoadenitis in the Sprague-Dawley rat. (13955749)
1963
47
A CASE OF ACUTE DACRYOADENITIS. (20321761)
1940
48
ACUTE DACRYOADENITIS DUE TO THE MORAX-AXENFELD DIPLOBACILLUS. (18169461)
1937
49
Traumatic Periostitis of Orbit: Further Note on Case shown November 13, 1931, as one of Dacryoadenitis. (19988799)
1932
50
A Case of Acute Suppurative Dacryoadenitis. (16692254)
1912

Variations for Dacryoadenitis

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Expression for genes affiliated with Dacryoadenitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dacryoadenitis

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Pathways for genes affiliated with Dacryoadenitis

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51PathCards, 31KEGG, 55R&D Systems, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN
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Compounds for genes affiliated with Dacryoadenitis

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46Novoseek, 3BitterDB, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Dacryoadenitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1aristolochic acid46 310.7TGFB1, HSPG2
2ang ii469.6TGFB1, HSPG2
3neomycin469.6TGFB1, HSPG2
4losartan46 52 30 1212.6HSPG2, TGFB1
5kainate46 3010.6TGFB1, HSPG2
6verapamil46 30 52 25 1213.5TGFB1, HSPG2
7nifedipine46 30 52 1212.5HSPG2, TGFB1
8choline46 25 1211.5TGFB1, HSPG2
9dmso469.4TGFB1, HSPG2
10indomethacin46 30 62 1212.4TGFB1, HSPG2
11aspirin46 52 30 2512.3HSPG2, TGFB1
12rantes469.2IL21, TGFB1

GO Terms for genes affiliated with Dacryoadenitis

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17Gene Ontology
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Cellular components related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.3TGFB1, HSPG2
2extracellular spaceGO:0056158.6IL21, TGFB1, HSPG2
3extracellular regionGO:0055768.6TGFB1, APOF, HSPG2

Biological processes related to Dacryoadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:0707239.4TGFB1, PMVK
2chondrocyte differentiationGO:0020629.4TGFB1, HSPG2
3positive regulation of interleukin-17 productionGO:0327409.2IL21, TGFB1

Products for genes affiliated with Dacryoadenitis

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Sources for Dacryoadenitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet