Decubitus Ulcer disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Decubitus Ulcer

Sources:
⁸Disease Ontology, ³³MedlinePlus, ⁶³Wikipedia, ³²MalaCards
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MedlinePlus:³³ Pressure sores are areas of damaged skin caused by staying in one position for too long. they commonly form where your bones are close to your skin, such as your ankles, back, elbows, heels and hips. you are at risk if you are bedridden, use a wheelchair, or are unable to change your position. pressure sores can cause serious infections, some of which are life-threatening. they can be a problem for people in nursing homes. you can prevent the sores by keeping skin clean and dry changing position every two hours using pillows and products that relieve pressure pressure sores have a variety of treatments. advanced sores are slow to heal, so early treatment is best.

MalaCards: Decubitus Ulcer, also known as pressure ulcer, is related to meningitis and diabetic foot ulcers. An important gene associated with Decubitus Ulcer is NDUFS7 (NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds idpn and diflunisal have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord.

Disease Ontology:⁸ Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure.

Wikipedia:⁶³ Pressure ulcers, also known as decubitus ulcers or bedsores, are localized injuries to the skin and/or... more...

Aliases & Classifications for Decubitus Ulcer

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ³³MedlinePlus, ⁵⁶SNOMED-CT, ²⁷ICD9CM, ³⁴MeSH, ³⁹NCIt
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Aliases & Descriptions:

decubitus ulcer ⁸ ¹⁰

pressure ulcer ⁸ ⁴⁴ ⁶⁰

pressure sores ⁸ ³³

decubitus ulcer, lower back ⁸

decubitus ulcer, other site ⁸

decubitus ulcer, upper back ⁸

decubitus ulcer any site ⁸

decubitus ulcer, elbow ⁸

decubitus ulcer ⁸

pressure sore ⁸

External Ids:

Disease Ontology⁸ DOID:8717

ICD9CM²⁷ 707.0, 707.00

SNOMED-CT⁵⁶ 156424003, 399912005, 142668003 165258002, 418172001, 201248003, 90144002, 420226006, 400192002, 28103007, more

MeSH³⁴ D003668

NCIt³⁹ C50706

UMLS⁶⁰ C0011127

Related Diseases for Decubitus Ulcer

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Decubitus Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)

id	Related Disease	Score	Top Affiliating Genes
1	meningitis	10.2
2	diabetic foot ulcers	10.1
3	quadriplegia	10.1
4	chronic ulcer of skin	10.1
5	rheumatic fever	10.1
6	subdural empyema	10.1
7	atopic dermatitis	10.1
8	necrotizing fasciitis	10.1
9	ulcer of lower limbs	10.1
10	bacterial meningitis	10.1
11	bursitis	10.1
12	dermatitis	10.1
13	endocarditis	10.1
14	fasciitis	10.1
15	hypothyroidism	10.1
16	lipoma	10.1
17	multiple myeloma	10.1
18	myeloma	10.1
19	myiasis	10.1
20	myocardial infarction	10.1
21	nephrotic syndrome	10.1
22	paraplegia	10.1
23	pneumonia	10.1
24	prostatitis	10.1
25	scabies	10.1
26	spina bifida	10.1
27	bacteriuria	10.0
28	gas gangrene	10.0
29	myositis ossificans	10.0
30	myositis	10.0
31	hepatic encephalopathy	10.0	ALB
32	nutritional deficiency disease	10.0	TTR, ALB
33	hyperthyroxinemia	10.0	TTR, ALB
34	protein-energy malnutrition	10.0	TTR, ALB
35	primary hyperoxaluria	10.0	ALB, TTR
36	autonomic neuropathy	10.0	ALB, TTR
37	galactosemia	10.0	TTR, ALB
38	burns	9.9
39	locked-in syndrome	9.9
40	verrucous carcinoma	9.9
41	histiocytoma	9.9
42	multiple sclerosis	9.9
43	neuropathy	9.9
44	osteomyelitis	9.9
45	spinal cord disease	9.9
46	syphilis	9.9
47	tertiary syphilis	9.9
48	neurologic diseases	9.9

Graphical network of the top 20 diseases related to Decubitus Ulcer:

Clinical Features for Decubitus Ulcer

Drugs & Therapeutics for Decubitus Ulcer

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Decubitus Ulcer

Anatomical Context for Decubitus Ulcer

Sources:
³²MalaCards
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MalaCards organs/tissues related to Decubitus Ulcer:

³²

Skin, Bone, Spinal cord, Prostate

Animal Models for Decubitus Ulcer or affiliated genes

Publications for Decubitus Ulcer

Sources:
⁵⁰PubMed
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Articles related to Decubitus Ulcer:

(show top 50) (show all 119)

id	Title	Authors	Year
1	Allogeneic platelet leucocyte-gel to treat occipital decubitus ulcer in a neonate: a case report. (22395354)	Perotti G.... Perotti C.	2012
2	Sacral decubitus ulcers and bacterial meningitis. (22365531)	Honigman L.... Friedberg R.	2012
3	Pressure sores and myiasis: flesh flies (Diptera: Sarcophagidae) complicating a decubitus ulcer. (21294953)	Iqbal J.... Hall M.J.	2011
4	Giant lipoma of posterior neck with bleeding decubitus ulcer: a rare entity. (21031074)	Verma S.... Singh R.	2010
5	Successful treatment of chronic decubitus ulcer with 0.1% dirhamnolipid ointment. (18544299)	Piljac A.... Piljac G.	2008
6	Multidrug-resistant Enterococcus raffinosus from a decubitus ulcer: a case report. (18372268)	Savini V.... D'Antonio D.	2008
7	Two simple leg net devices designed to protect lower-extremity skin grafts and donor sites and prevent decubitus ulcer. (17211210)	Hedman T.L.... Holcomb J.B.	2007
8	Cautious use of administrative data for decubitus ulcer outcome reporting. (16849783)	Polancich S.... Prosser J.	2006
9	Moxifloxacin distribution in the interstitial space of infected decubitus ulcer tissue of patients with spinal cord injury measured by in vivo microdialysis. (17008236)	Burkhardt O.... Barth J.	2006
10	The influence of a change in medicare reimbursement on the effectiveness of stage III or greater decubitus ulcer home health nursing care. (16443958)	Eaton M.K.	2005
11	Phenytoin-induced lymphocytic chemotaxis, angiogenesis and accelerated healing of decubitus ulcer in a patient with stroke. (15080024)	Pitiakoudis M.... Piperidou C.	2004
12	Overwhelming cranial and spinal subdural empyema secondary infected sacral decubitus ulcers. (14756492)	Baker R.P.... Coakham H.B.	2003
13	Decubitus ulcer standards and guidelines. (10568935)	D'Andrea D.D.	1998
14	An evaluation of current risk assessment scales for decubitus ulcer in general inpatients and wheelchair users. (9619655)	Anthony D.... Unsworth J.	1998
15	Nutritional status of patients with decubitus ulcers, and changes in the skin blood flow when the sacral region was compressed]. (9301264)	Miyajima Y.... Fukumoto I.	1997
16	Efficacy of hydrocolloid occlusive dressing technique in decubitus ulcer treatment: a comparative study. (8826783)	Kim Y.C.... Kim Y.S.	1996
17	Susceptibility to decubitus ulcer formation. (8129586)	Meijer J.H.... Ribbe M.W.	1994
18	The effect of diapulse therapy on the healing of decubitus ulcer. (7982015)	Comorosan S.... Stelea S.	1993
19	The influence of various support systems for decubitus ulcer prevention on contact pressure and percutaneous oxygen pressure. (2061586)	Neander K.D.... Birkenfeld R.	1991
20	Unusual aspects of the decubitus ulcer. (3254235)	Parish L.C.... Crissey J.T.	1988
21	Recent findings on decubitus ulcer pathology: implications for care. (3510153)	Seiler W.O.... StAohelin H.B.	1986
22	Perineal decubitus ulcer with urethro-cutaneous fistula without bilateral ischiectomy: case report. (3534693)	Ramasastry S.S.... Schwentker F.S.	1986
23	Decubitus ulcer care: a comparative study. (3850687)	Kurzuk-Howard G.... Palmieri A.	1985
24	Decubitus ulcer warfare: product vs. process. (6562057)	Tooman T.... Patterson J.	1984
25	Decubitus ulcer prevention: a new investigative method using transcutaneous oxygen tension measurement. (6655181)	Seiler W.O.... StAohelin H.B.	1983
26	Medical aspects of the decubitus ulcer. (7095957)	Andersen K.E.... Kvorning S.A.	1982
27	Product report: decubitus ulcer treatment. (10257166)		1982
28	16 steps to better decubitus ulcer care. (6911037)	Morley M.	1981
29	Interstitial fluid flow as a factor in decubitus ulcer formation. (7328094)	Reddy N.P.... Cochran G.V.	1981
30	Community nursing care study: decubitus ulcer. (6909758)	Davidson M.M.	1981
31	Decubitus ulcer treatment. (6899705)	Yeats H.S.	1980
32	Skin oxygen tension as a function of imposed skin pressure: implication for decubitus ulcer formation. (447992)	Seiler W.O.... StAohelin H.B.	1979
33	The decubitus ulcer. (457313)	Parish L.C.... Witkowski J.A.	1979
34	Mechanisms of decubitus ulcer formation--an hypothesis. (634177)	Krouskop T.A.... Secor J.W.	1978
35	Decubitus ulcer management: a simple program. (925551)	Fowler L.P.... Price B.	1977
36	Turnover island flap of gluteus maximus muscle for the repair of sacral decubitus ulcer. (4598941)	Stallings J.O.... Converse J.M.	1974
37	A preliminary note on demographic and personality correlates of decubitus ulcer incidence. (4748964)	Cull J.G.... Smith O.H.	1973
38	New system for supporting the patient in the management of decubitus ulcer: preliminary report. (5438032)	Rowan N.M.	1970
39	A protective device for a decubitus ulcer. (5484650)	Blumenthal F.S.... Wanchik J.	1970
40	Care of the decubitus ulcer patient. (5780823)	Spira M.... Gerow F.	1969
41	Decubitus ulcer. A double blind study of an old problem and a new treatment. (4888158)	Settel E.	1969
42	Bucket seat treatment for decubitus ulcer. (5220504)	Ackerman M.	1966
43	Surgical treatment of the decubitus ulcer over the ischial tuberosity (in paraplegic patients). (5883525)	van Enst W.	1965
44	AN INTERESTING DECUBITUS ULCER CLOSURE. (14132877)	COMARR A.E.	1964
45	A preliminary report of a study of decubitus ulcer care. (13780901)	VERHONICK P.J.	1961
46	Decubitus ulcer care. (13297543)	BURSTON I.... REEDER T.P.	1956
47	Decubitus ulcer in rheumatic fever treated with cortisone. (14861016)	BARROW J.G.... SIKES C.R.	1951
48	The surgical repair of decubitus ulcer in paraplegics; further observations. (18119037)	BLOCKSMA R.... GREELEY P.W.	1949
49	The operative treatment of decubitus ulcer. (20254154)	Croce E.J.... BEAKES C.H.	1947
50	The Operative Treatment of Decubitus Ulcer. (17858729)	Croce E.J.... Shearer T.P.	1946

Genes related to Decubitus Ulcer

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Decubitus Ulcer:

id	Symbol	Description	Score	Implication
1	NDUFS7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)	21.00	GeneCards inferred : Disorders (show sections)
2	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	19.00	GeneCards inferred : Disorders (show sections)
3	TTR	transthyretin	17.00	GeneCards inferred : Disorders (show sections)
4	ALB	albumin	15.00	GeneCards inferred : Publications, Disorders (show sections)
5	MAGEE1	melanoma antigen family E, 1	13.00	GeneCards inferred : Disorders (show sections)
6	OSCAR	osteoclast associated, immunoglobulin-like receptor	11.00	GeneCards inferred : Disorders (show sections)
7	PRLH	prolactin releasing hormone	9.00	GeneCards inferred : Disorders (show sections)
8	MDS2	myelodysplastic syndrome 2 translocation associated	7.00	GeneCards inferred : Disorders (show sections)
9	ZC3H12D	zinc finger CCCH-type containing 12D	5.00	GeneCards inferred : Disorders (show sections)
10	BSN	bassoon presynaptic cytomatrix protein	3.00	GeneCards inferred : Disorders (show sections)

Products for genes related to Decubitus Ulcer disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	6	6	9
2	LSBio	-	-	10

Genetic Variations for Decubitus Ulcer

Expression for genes affiliated with Decubitus Ulcer

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Decubitus Ulcer

Search GEO for disease gene expression data for Decubitus Ulcer.

Pathways for genes affiliated with Decubitus Ulcer

Sources:
³⁷NCBI BioSystems Database
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Pathways related to Decubitus Ulcer according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	FOXA2 and FOXA3 transcription factor networks³⁷	9.8	ALB, TTR

Compounds for genes affiliated with Decubitus Ulcer

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ²⁴HMDB, ²⁸IUPHAR, ⁴⁹PharmGKB
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Compounds related to Decubitus Ulcer according to GeneCards/GeneDecks:

(show all 14)

id	Compound	Score	Top Affiliating Genes
1	idpn⁴⁴	10.0	ALB, TTR
2	diflunisal⁴⁴ ¹¹	11.0	ALB, TTR
3	Levothyroxine¹¹	10.0	ALB, TTR
4	Liotrix¹¹	10.0	TTR, ALB
5	Liothyronine¹¹ ²⁴	11.0	ALB, TTR
6	flurbiprofen⁴⁴ ²⁸ ⁴⁹ ¹¹	13.0	ALB, TTR
7	cellulose acetate⁴⁴	9.9	ALB, TTR
8	glutaraldehyde⁴⁴	9.9	TTR, ALB
9	vitamin b6⁴⁴	9.9	ALB, TTR
10	25-hydroxyvitamin d⁴⁴	9.8	ALB, TTR
11	phosphorus⁴⁴	9.8	TTR, ALB
12	salicylic acid⁴⁴ ²⁸	10.8	ALB, TTR
13	diclofenac⁴⁴ ²⁸ ⁴⁹ ¹¹	12.7	ALB, TTR
14	vitamin b12⁴⁴	9.5	ALB, TTR