MCID: DDF001
MIFTS: 41

Dedifferentiated Liposarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Dedifferentiated Liposarcoma

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MalaCards based summary: Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to liposarcoma and fibrous histiocytoma. An important gene associated with Dedifferentiated Liposarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are Oncogene Induced Senescence and DNA damage ATM ATR regulation of G1 S checkpoint. The compounds vitamin k2 and 10-hydroxycamptothecin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and colon, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Aliases & Classifications for Dedifferentiated Liposarcoma

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Sources:
47Orphanet, 60UMLS, 61UMLS via Orphanet, 26ICD10 via Orphanet
See all sources

Dedifferentiated Liposarcoma, Aliases & Descriptions:

Name: Dedifferentiated Liposarcoma 47
Liposarcoma, Dedifferentiated 60
 
Ddls 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
dedifferentiated liposarcoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult


External Ids:

Orphanet47 99970
UMLS via Orphanet61 C0205824
ICD10 via Orphanet26 C49

Related Diseases for Dedifferentiated Liposarcoma

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Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.8CDK4, MDM2, HMGA2, DES
2fibrous histiocytoma31.2ACTC1, DES
3myxoid liposarcoma30.8MDM2, CDK4
4lipoma30.6CDK4, MDM2, HMGA2, DES
5leiomyosarcoma30.5DES, ACTC1, MDM2, CDK4
6sarcoma30.3DES, ACTC1, HMGA2, MDM2, CDK4
7rhabdomyosarcoma30.2DES, ACTC1, MDM2, CDK4
8leukemia30.1CEBPA, HMGA2, MDM2, CDK4
9histiocytoma10.6
10infantile myofibromatosis10.5DES
11sertoli cell tumor10.4DES
12chondroma10.4HMGA2
13fasciitis10.4ACTC1
14lipomatosis10.4HMGA2
15connective tissue benign neoplasm10.4CDK4, MDM2
16leukemoid reaction10.3
17pleomorphic liposarcoma10.3
18anaplastic oligodendroglioma10.3CDK4, MDM2
19uterine sarcoma10.3DES, MDM2
20uveal melanoma10.3CDK4, MDM2
21grade iii astrocytoma10.3CDK4, MDM2
22epithelioid leiomyosarcoma10.2ACTC1, DES
23pseudosarcomatous fibromatosis10.2DES, ACTC1
24spindle cell carcinoma10.2ACTC1, DES
25spindle cell sarcoma10.2DES, ACTC1
26desmoid disease, hereditary10.2DES, ACTC1
27cutaneous fibrous histiocytoma10.2ACTC1, DES
28pre-eclampsia10.2AFP
29oligodendroglioma10.2MDM2, CDK4
30adenosarcoma10.2DES, ACTC1
31dermatofibrosarcoma protuberans10.2ACTC1, DES
32endometrial stromal sarcoma10.2ACTC1, DES
33acute lymphoblastic leukemia, childhood10.2MDM2, CDK4
34rhabdoid tumor10.2ACTC1, DES
35mesothelioma, somatic10.2CDK4, DES
36angiomyolipoma10.2ACTC1, DES
37glomus tumor10.2DES, ACTC1
38fibroma10.2DES, ACTC1
39fibromatosis10.2ACTC1, DES
40abrikosov's tumor10.2DES, ACTC1
41giant cell tumor10.2DES, ACTC1
42inflammatory myofibroblastic tumor10.2
43paraganglioma10.2
44cervicitis10.2
45esophagitis10.2
46hyperparathyroidism10.2
47hyperthyroidism10.2
48laryngitis10.2
49retroperitoneal sarcoma10.2
50hemangioendothelioma10.2

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to dedifferentiated liposarcoma

Symptoms for Dedifferentiated Liposarcoma

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Drugs & Therapeutics for Dedifferentiated Liposarcoma

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Drug clinical trials:

Search ClinicalTrials for Dedifferentiated Liposarcoma

Search NIH Clinical Center for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

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Anatomical Context for Dedifferentiated Liposarcoma

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MalaCards organs/tissues related to Dedifferentiated Liposarcoma:

31
Bone, Lung, Colon, Lymph node, Spleen, Adipocyte, Liver

Animal Models for Dedifferentiated Liposarcoma or affiliated genes

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MGI Mouse Phenotypes related to Dedifferentiated Liposarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.7CDK4, HMGA2, CEBPA, AFP
2MP:00020068.7CDK4, MDM2, CEBPA, AFP
3MP:00053898.4AFP, CEBPA, HMGA2, MDM2, CDK4
4MP:00053868.0DES, AFP, CEBPA, HMGA2, MDM2, CDK4
5MP:00053847.6CEBPA, ACTC1, CALR, MDM2, CDK4
6MP:00053697.6CDK4, MDM2, CALR, ACTC1, CEBPA, DES
7MP:00053787.5CEBPA, ACTC1, CALR, HMGA2, MDM2, CDK4
8MP:00053857.5DES, CEBPA, ACTC1, CALR, MDM2, CDK4
9MP:00053767.0DES, AFP, CEBPA, ACTC1, CALR, HMGA2
10MP:00107687.0DES, AFP, CEBPA, ACTC1, CALR, MDM2

Publications for Dedifferentiated Liposarcoma

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Articles related to Dedifferentiated Liposarcoma:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
Dedifferentiated Liposarcoma of the Gastroesophageal Junction. (25690861)
2015
2
Immunohistochemical, cytogenetic, and molecular cytogenetic characterization of both components of a dedifferentiated liposarcoma: implications for histogenesis. (25550570)
2015
3
Dedifferentiated liposarcoma involving the spleen and splenic hilum: a report of a case with a rare growth pattern. (25594652)
2015
4
Metastasis in dedifferentiated liposarcoma: Predictors and outcome in 148 patients. (25659772)
2015
5
Primary dedifferentiated liposarcoma of the lung with rhabdomyoblastic and chrondroblastic differentiation. (24612243)
2014
6
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
7
Is the nonlipomatous component of dedifferentiated liposarcoma always soft tissue on CT? Analysis of CT densities and correlation with rate of growth in 60 patients. (25287680)
2014
8
Loss of heterozygosity and microsatellite instability are rare in sporadic dedifferentiated liposarcoma: a study of 43 well-characterized cases. (24878023)
2014
9
Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases. (25126005)
2014
10
MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. (24515760)
2014
11
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
12
High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma. (23852861)
2013
13
Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma. (23569312)
2013
14
Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. (23416162)
2013
15
Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability. (22241790)
2012
16
Dedifferentiated liposarcoma of the rectum: a case report. (23139616)
2012
17
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. (23084521)
2012
18
Renal dedifferentiated liposarcoma with intra-caval tumor thrombus: A rare case. (22919143)
2012
19
Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. (22301498)
2012
20
Liposarcoma of the chest wall. Transformation of dedifferentiated liposarcoma from a recurrent lipoma. (22886125)
2012
21
High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma. (21793095)
2011
22
Primary (de novo) dedifferentiated liposarcoma in the extremities: a multi-institution Tohoku Musculoskeletal Tumor Society study of 18 cases in northern Japan. (21795247)
2011
23
Well-differentiated and dedifferentiated liposarcomas. (19688222)
2010
24
Dedifferentiated liposarcoma of retroperitoneum: spectrum of imaging findings in 15 patients. (20416485)
2010
25
Dedifferentiated liposarcoma of the retroperitoneum. (20369054)
2010
26
Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. (19946100)
2009
27
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. (19589790)
2009
28
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component: report of two cases. (19135935)
2009
29
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. (18214854)
2008
30
Dedifferentiated liposarcoma presenting as jejunal polyp. Case report. (18184419)
2007
31
Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation. (17213023)
2007
32
Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses. (18036404)
2007
33
Dedifferentiated liposarcoma arising from the sigmoid mesocolon: a case report. (17696239)
2007
34
alpha-fetoprotein expression in a dedifferentiated liposarcoma. (16489442)
2006
35
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
36
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
37
Primary dedifferentiated liposarcoma of the lung. (15910606)
2005
38
Alterations of the RB1 gene in dedifferentiated liposarcoma. (15933756)
2005
39
Dedifferentiated liposarcoma with extensive lymphoid component. (15991843)
2005
40
Best cases from the AFIP: Dedifferentiated liposarcoma of soft tissue with high-grade osteosarcomatous dedifferentiation. (16009825)
2005
41
Dedifferentiated liposarcoma of the oral cavity with angiosarcomatous dedifferentiation. (15806379)
2005
42
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. (15221942)
2004
43
Establishment of a novel human dedifferentiated liposarcoma cell line, FU-DDLS-1: conventional and molecular cytogenetic characterization. (12579306)
2003
44
Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. (12640106)
2003
45
A leukemoid reaction in a patient with a dedifferentiated liposarcoma. (11391379)
2001
46
Fine needle aspiration cytology of a dedifferentiated liposarcoma: report of a case with histologic and immunohistochemical follow-up. (11480734)
2001
47
Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. (9706974)
1998
48
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
49
Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. (9071997)
1997
50
Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. (7977944)
1994

Variations for Dedifferentiated Liposarcoma

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Expression for genes affiliated with Dedifferentiated Liposarcoma

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Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for genes affiliated with Dedifferentiated Liposarcoma

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Pathways related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDK4, MDM2
29.8CDK4, MDM2
39.8CDK4, MDM2
49.8MDM2, CDK4
59.6CEBPA, MDM2
69.6MDM2, CEBPA
79.6MDM2, AFP
89.5CEBPA, AFP
9
Show member pathways
9.3CDK4, MDM2, HMGA2
10
Show member pathways
9.3ACTC1, DES
119.3CEBPA, MDM2, CDK4
129.2MDM2, HMGA2, CEBPA
13
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.9CDK4, MDM2, CALR

Compounds for genes affiliated with Dedifferentiated Liposarcoma

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Compounds related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1vitamin k2439.9AFP, CDK4
210-hydroxycamptothecin439.9MDM2, AFP
3roscovitine439.8CDK4, MDM2
4orcein439.7ACTC1, DES
5s 100439.7DES, ACTC1
6carboplatin43 49 1211.6AFP, MDM2, CDK4
7reticulin439.6DES, ACTC1
8adpribose439.6CDK4, MDM2, DES
9mucicarmine439.6ACTC1, DES
10ifosfamide43 1210.6MDM2, AFP
11valine439.5AFP, MDM2, CDK4
12diethylstilbestrol43 28 1211.5AFP, MDM2
135fluorouracil439.5AFP, MDM2, CDK4
14agar439.5CDK4, MDM2, AFP
15adriamycin439.4MDM2, AFP, DES
16paclitaxel43 49 1211.4AFP, MDM2, CDK4
17imatinib43 49 1211.3MDM2, ACTC1, DES
18b 723439.2ACTC1, AFP, DES
19con a439.2CALR, AFP
20cisplatin43 49 59 1212.2AFP, HMGA2, MDM2, CDK4
21estradiol43 24 1211.1CDK4, MDM2, AFP, DES
22thymidine43 2410.1DES, AFP, MDM2, CDK4
23actinomycin d439.1DES, AFP, HMGA2, MDM2
24vitamin d439.0CDK4, CALR, AFP
25proline438.9CDK4, MDM2, DES
26hydrogen43 249.8CDK4, MDM2, CALR, AFP
27doxorubicin43 49 1210.7DES, AFP, HMGA2, MDM2, CDK4
28oligonucleotide438.7CDK4, MDM2, CALR, AFP
29arginine438.7DES, CALR, MDM2, CDK4
30zinc43 249.7CDK4, MDM2, CALR, AFP
31nitric oxide43 24 1210.6DES, CALR, MDM2, CDK4
32h2o2438.6DES, AFP, CALR, MDM2
33fatty acid438.5DES, AFP, CEBPA, CALR
34cysteine438.5DES, CALR, MDM2, CDK4
35progesterone43 28 59 24 1212.5DES, AFP, ACTC1, MDM2, CDK4
36vegf438.5DES, AFP, ACTC1, MDM2, CDK4
37threonine438.3DES, AFP, CALR, MDM2, CDK4
38serine438.2CDK4, MDM2, CALR, AFP, DES
39paraffin438.1DES, AFP, ACTC1, HMGA2, MDM2, CDK4
40glycogen43 249.1CDK4, MDM2, ACTC1, CEBPA, AFP, DES
41estrogen438.1DES, AFP, CEBPA, ACTC1, MDM2, CDK4
42dexamethasone43 49 28 1210.8AFP, CEBPA, ACTC1, CALR, MDM2, CDK4
43iron43 248.7DES, AFP, ACTC1, CALR, MDM2, CDK4
44testosterone43 59 24 1210.7DES, AFP, ACTC1, CALR, MDM2, CDK4
45steroid437.7DES, AFP, ACTC1, CALR, MDM2, CDK4
46oxygen43 248.7DES, AFP, ACTC1, CALR, MDM2, CDK4
47tyrosine437.7DES, AFP, ACTC1, CALR, MDM2, CDK4
48calcium43 49 24 1210.7DES, AFP, ACTC1, CALR, MDM2, CDK4
49glucose437.6DES, AFP, CEBPA, ACTC1, CALR, CDK4
50retinoic acid43 248.2DES, AFP, CEBPA, ACTC1, CALR, HMGA2

GO Terms for genes affiliated with Dedifferentiated Liposarcoma

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Cellular components related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058297.8CDK4, MDM2, CALR, ACTC1, DES

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:00711579.9MDM2, CDK4
2organ regenerationGO:00311009.7CDK4, CEBPA
3negative regulation of intracellular steroid hormone receptor signaling pathwayGO:00331449.5HMGA2, CALR
4response to testosteroneGO:00335749.5CALR, CDK4
5cellular response to lithium ionGO:00712859.4CEBPA, CALR
6muscle filament slidingGO:00300499.4ACTC1, DES
7protein localization to nucleusGO:00345049.4MDM2, CALR
8positive regulation of gene expressionGO:00106289.1MDM2, HMGA2, CALR
9negative regulation of apoptotic processGO:00430669.1MDM2, HMGA2, ACTC1
10positive regulation of cell proliferationGO:00082848.8CALR, MDM2, CDK4
11negative regulation of transcription from RNA polymerase II promoterGO:00001228.7CEBPA, CALR, HMGA2, MDM2
12negative regulation of transcription, DNA-templatedGO:00458928.6MDM2, HMGA2, CALR
13response to drugGO:00424938.6CDK4, MDM2, CALR, ACTC1

Products for genes affiliated with Dedifferentiated Liposarcoma

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Sources for Dedifferentiated Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet