MCID: DDF001
MIFTS: 38

Dedifferentiated Liposarcoma malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Dedifferentiated Liposarcoma

About this section
Sources:
51Orphanet, 65UMLS, 47Novoseek, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Dedifferentiated Liposarcoma:

Name: Dedifferentiated Liposarcoma 51
Liposarcoma, Dedifferentiated 65
 
Liposarcoma Dedifferentiated 47
Ddls 51


Classifications:

Orphanet: 51 
Rare tumors


Characteristics (Orphanet epidemiological data):

51
dedifferentiated liposarcoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult


External Ids:

Orphanet51 99970
ICD10 via Orphanet28 C49
UMLS via Orphanet66 C0205824

Summaries for Dedifferentiated Liposarcoma

About this section
MalaCards based summary: Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to adult liposarcoma and connective tissue disease. An important gene associated with Dedifferentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase), and among its related pathways are Aurora A signaling and GADD45 Pathway. Affiliated tissues include bone, lung and colon, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Dedifferentiated Liposarcoma

About this section

Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1adult liposarcoma30.8CDKN2A, TP53
2connective tissue disease30.6CDK4, MDM2, TP53
3myxoid liposarcoma30.3CDK4, HMGA2, MDM2, TP53
4liposarcoma11.3
5sarcoma10.7
6fibrous histiocytoma10.6
7histiocytoma10.6
8lipoma10.5
9connective tissue benign neoplasm10.5
10connective tissue cancer10.5
11leiomyosarcoma10.5
12malignant mesenchymal tumor10.5
13soft tissue sarcoma10.5
14solitary fibrous tumor10.5
15pleomorphic liposarcoma10.4
16leukemoid reaction10.3
17retroperitoneal sarcoma10.3
18antenatal multiminicore disease with arthrogryposis multiplex congenita10.3CDK4, MDM2
19cheek mucosa cancer10.3CDK4, MDM2
20bone remodeling disease10.3CDK4, MDM2
21lipodermatosclerosis10.3CDK4, MDM2
22atypical mycobacteriosis, familial10.3CDK4, CDKN2A
23metabolic syndrome x10.3CDK4, MDM2
24extrahepatic bile duct lipoma10.3CDK4, MDM2
25acute frontal sinusitis10.3CDK4, MDM2
26malignant eyelid melanoma10.2CDK4, CDKN2A
27keratoacanthoma10.2CDK4, MDM2
28heart septal defect10.2CDKN2A, MDM2
29spigelian hernia-cryptorchidism syndrome10.2ACTC1, DES
30necrotizing fasciitis10.2ACTC1, DES
31plasmalogens synthesis deficiency isolated10.2CDKN2A, DES
32exencephaly10.2CDK4, CDKN2A
33kidney leiomyosarcoma10.2ACTC1, DES
34lymphangiosarcoma10.2ACTC1, DES
35lung oat cell carcinoma10.2ACTC1, DES
36bladder colonic type adenocarcinoma10.2ACTC1, DES
37benign multicystic peritoneal mesothelioma10.2ACTC1, DES
38psoriasis10.2ACTC1, DES
39uveal diseases10.2DES, MDM2
40internal hemorrhoid10.2ACTC1, DES
41pulmonary venous return anomaly10.2ACTC1, DES
42infantile recurrent chronic multifocal osteomyolitis10.2ACTC1, DES
43microcystic variant infiltrating bladder urothelial carcinoma10.2ACTC1, CDKN2A
44malignant hyperthermia arthrogryposis torticollis10.2DES, HMGA2
45rift valley fever10.2ACTC1, DES
46hand dermatosis10.2ACTC1, CDKN2A
47pyosalpinx10.2ACTC1, DES
48mixed cell adenoma10.2DES, HMGA2
49metal metabolism disorder10.2DES, HMGA2
50ichthyosis, x-linked10.2

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to dedifferentiated liposarcoma

Symptoms for Dedifferentiated Liposarcoma

About this section

Drugs & Therapeutics for Dedifferentiated Liposarcoma

About this section

Drugs for Dedifferentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Trabectedinapproved, investigationalPhase 256114899-77-3108150
Synonyms:
ET-743
ET743
Ecteinascidin
Ecteinascidin 743
NSC 684766
SID144206315
 
SID144206787
Yondelis
ecteinascidin
ecteinascidin 743
et-743
et743
nsc 684766
2
IfosfamideapprovedPhase 23583778-73-23690
Synonyms:
(+-)-Ifosfamid
(+-)-Ifosphamide
(+-)-Tetrahydro-N,3-bis(2-chloroethyl)-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
(D,L)-Ifosfamide
(R,S)-Ifosphamide
(R,S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
2,3-(N,N(sup 1)-Bis(2-chloroethyl)diamido)-1,3,2-oxazaphosphoridinoxyd
2,3-N,N(sup 1)-Bis(2-chloroethyl)diamido-1,3,2-oxazaphosphoridinoxyd
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis( 2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (8CI)
2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide
3,} 2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorine oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,3,2-oxazaphosphorineoxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2- oxide
3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
36341-88-5
3778-73-2
84711-20-6
A 4942
AB00513932
AC-2113
AC1L1GHW
ASTA Z 4942
Ambap3778-73-2
Asta Z 4942
BPBio1_000865
BRN 0611835
BSPBio_000785
C07047
CAS-3778-73-2
CCRIS 352
CHEBI:5864
CHEMBL1024
CID3690
Cyfos
D00343
D007069
DB01181
EINECS 223-237-3
HMS1570H07
HMS2090M12
HMS2093N07
HSDB 7023
Holoxan
Holoxan 1000
I-Phosphamide
I06-0494
IFEX (TN)
Ifex
Ifosfamid
Ifosfamida
Ifosfamida [INN-Spanish]
Ifosfamide
 
Ifosfamide (JAN/USP/INN)
Ifosfamide Sterile
Ifosfamide [USAN:INN:BAN:JAN]
Ifosfamidum
Ifosfamidum [INN-Latin]
Ifosphamide
Ifsofamide
Iphosphamid
Iphosphamid(e)
Iphosphamide
Iso Endoxan
Iso-Endoxan
Isoendoxan
Isofosfamide
Isophosphamide
Isosfamide
LS-102
LS-99799
MJF 9325
MJF-9325
MLS002154021
Mitoxana
Mitoxana, Ifex, Ifosfamide
MolPort-003-666-704
N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
N,N-Bis(beta-chloroethyl)-amino-N',O-propylene-phosphoric acid ester diamide
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid
N-(2-Chloraethyl)-N'-(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid [German]
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylen ephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid diamide
N-(2-Chloroethyl)-N'-(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide
N-(2-Chloroethyl)-N-(3-(2-chloroethyl)-2-oxido-1,3,2-oxazaphosphinan-2-yl)amine
NCGC00016639-01
NCGC00179435-01
NCI-C01638
NCI60_000233
NPFAPI-04
NSC 109,724
NSC 109724
NSC-109,724
NSC-109724
NSC109,724
NSC109724
Naxamide
Prestwick0_000833
Prestwick1_000833
Prestwick2_000833
Prestwick3_000833
S1302_Selleck
SMR001233348
SPBio_002706
STL058690
UNII-UM20QQM95Y
WLN: T6NPOTJ AM2G BO B2G
Z 4942
Z-4942
Z4942
ifosfamide
isosfamide
{3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]perhydro-2H-1,
3
MechlorethamineapprovedPhase 241051-75-24033
Synonyms:
.Beta.,.beta.'-Dichlorodiethyl-N-methylamine
1, 5-Dichloro-3-methyl-3-azapentane hydrochloride
126-85-2 (N-oxide)
2,2'-Dichloro-N-me
2,2'-Dichloro-N-methyldiethylamine
2,2'-Dichlorodiethyl-methylamine
2,2'-dichloro-N-methyldiethylamine
2-Chloro-N-(2-chloroethyl)-N-methylethanamine
302-70-5 (N-oxide, hydrochloride)
51-75-2
55-86-7 (HYDROCHLORIDE)
AC1L1H9H
Antimit
BRN 0605323
BSPBio_001947
Bis(2-chloroethyl)methylamine
Bis(beta-chloroethyl) methylamine
Bis(beta-chloroethyl)methylamine
C07115
C5H11Cl2N
CCRIS 447
CHEBI:28925
CHEMBL427
CID4033
Carolysine
Caryolysin
Caryolysine
Chloramine (the nitrogen mustard)
Chlorethazine
Chlormethine
Chlormethine (INN)
Chlormethine [INN:BAN]
Chlormethinum [INN-Latin]
Cloramin
Clormetina
Clormetina [INN-Spanish]
D07671
DB00888
Di(2-chloroethyl)methylamine
Dichlor amine
Dichloren
DivK1c_000759
EINECS 200-120-5
ENT-25294
Embechine
Embichin
HMS1920J15
HMS2091B04
HMS502F21
HN-2
HN2
HSDB 5083
I14-8708
IBS-L0033631
IDI1_000759
KBio1_000759
KBio2_001369
KBio2_003937
KBio2_006505
KBio3_001447
KBioGR_001448
 
KBioSS_001369
LS-7559
MBA
Me chloroethamine
Mebichloramine
Mechlorethamine
Mechlorethamine hydrochloride
Mechlorethanamine
Mechloroethamine
Mecloretamina
Mecloretamina [Italian]
Methylbis(2-chloroethyl)amine
Methylbis(beta-chloroethyl)amine
Methyldi(2-chloroethyl)amine
Mitoxine (*Hydrochloride*)
MolPort-001-785-592
Mustargen
Mustine
Mustine note
Mutagen
N,N-Bis(2-chloroethyl)-N-methylamine
N,N-Bis(2-chloroethyl)methylamine
N,N-Di(chloroethyl)methylamine
N-Lost
N-Methyl lost
N-Methyl-2,2'-dichlorodiethylamine
N-Methyl-bis(2-chloroethyl)amine
N-Methyl-bis(beta-chloroethyl)amine
N-Methyl-bis-chloraethylamin
N-Methyl-bis-chloraethylamin [German]
N-Methyl-lost
N-Methyl-lost [German]
N-methyl-bis(2-chloroethyl)amine
NCGC00091835-02
NCGC00091835-03
NCGC00091835-04
NCGC00091835-05
NCI60_041682
NINDS_000759
NSC762
Nitol (*Hydrochloride*)
Nitrogen mustard
Nitrogen mustard (HN-2)
Nitrogranulogen
SPBio_000496
SPECTRUM1500375
Spectrum2_000448
Spectrum3_000484
Spectrum4_000924
Spectrum5_001702
Spectrum_000889
Stickstofflost (*Hydrochloride*)
Stickstofflost (ebewe)
T 1024
T-1024
TL 146
UNII-50D9XSG0VR
Valchlor
beta,Beta'-dichlorodiethyl-N-methylamine
beta,beta'-Dichlorodiethyl-N-methylamine
mechlorethamine
thyldiethylamine
β,β'-dichlorodiethyl-N-methylamine
4
Rosiglitazoneapproved, investigationalPhase 2219122320-73-477999
Synonyms:
(RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion
(±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione
122320-73-4
2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate
5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(methyl-(2-pyridyl)amino)ethoxy]phenyl]methyl] thiazolidine-2,4-dione
5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
AC-3459
AC1L2U9N
Avandia
BRD-A97437073-001-02-3
BRD-A97437073-001-03-1
BRL49653
BSPBio_002693
Brl 49653
Brl-49653
C18H19N3O3S
CID77999
D08491
DB00412
Gaudil
Gaudil (TN)
HMS1922J11
HMS2094O13
HSDB 7555
I06-0141
IDMB (1uM BRL49653, 1uM Dexamethasone, 0.5uM IBMX, 10ug/mL Insulin)
KBio2_002183
KBio2_004751
KBio2_007319
KBio3_001913
KBioGR_001609
 
KBioSS_002183
LS-151340
MolPort-002-508-212
NCGC00095124-01
NCGC00095124-02
NCGC00095124-03
RGZ
RSG
Rosi
Rosigilitazone
Rosigliazone maleate
Rosiglitazon
Rosiglitazona
Rosiglitazone
Rosiglitazone (INN)
Rosiglitazone Maleate
Rosiglitazone [INN:BAN]
Rosiglitazone maleate
Rosiglitazonum
Rosiglizole
S00306
SPBio_001142
SPECTRUM1504263
STOCK6S-23924
Spectrum2_001241
Spectrum3_000997
Spectrum4_001125
Spectrum5_001464
Spectrum_001703
TDZ 01
UNII-05V02F2KDG
[3H]rosiglitazone
rosiglitazona
rosiglitazone
rosiglitazone (Avandia)
rosiglitazonum
5
Maleic acidexperimentalPhase 2262110-16-7444972, 444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
6
MesnaPhase 22333375-50-6598
Synonyms:
2-Mercaptoethanesulfonate
2-Mercaptoethanesulfonic acid
 
CoM
Coenzyme M
HS-CoM
7Isophosphamide mustardPhase 2358

Interventional clinical trials:

idNameStatusNCT IDPhase
1KCP-330-020 SEAL (Selinexor in Advanced Liposarcoma)RecruitingNCT02606461Phase 2, Phase 3
2Ph II Cabazitaxel/Ifosfamide DD LiposarcomaRecruitingNCT01913652Phase 2
3Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated LiposarcomaRecruitingNCT02247544Phase 2
4Rosiglitazone in Treating Patients With LiposarcomaActive, not recruitingNCT00004180Phase 2
5Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical TrialActive, not recruitingNCT01692496Phase 2
6A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced SarcomasActive, not recruitingNCT02301039Phase 2
7A Phase II Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated LiposarcomaNot yet recruitingNCT02571829Phase 2
8Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter TrialTerminatedNCT01876043Phase 2
9Study Evaluating the Efficacy and Safety of IPI 504 in Patients With Advanced Dedifferentiated LiposarcomaWithdrawnNCT00969917Phase 2
10Phase 1 Safety Testing of SAR405838Active, not recruitingNCT01636479Phase 1

Search NIH Clinical Center for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

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Anatomical Context for Dedifferentiated Liposarcoma

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MalaCards organs/tissues related to Dedifferentiated Liposarcoma:

33
Bone, Lung, Colon, Lymph node, Liver, Adipocyte, Spleen

Animal Models for Dedifferentiated Liposarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Dedifferentiated Liposarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2CDK4, CDKN2A, MDM2, STAT6, TP53
2MP:00020067.8CDK4, CDKN2A, MDM2, STAT6, TP53
3MP:00053857.7ACTC1, CALR, CDK4, DES, MDM2, TP53
4MP:00107717.5CDK4, CDKN2A, HMGA2, MDM2, STAT6, TP53
5MP:00053897.5CDK4, CDKN2A, HMGA2, MDM2, STAT6, TP53
6MP:00053697.3ACTC1, CALR, CDK4, CDKN2A, DES, MDM2
7MP:00053847.1ACTC1, CALR, CDK4, CDKN2A, MDM2, STAT6
8MP:00107686.6ACTC1, CALR, CDK4, CDKN2A, DES, MDM2
9MP:00053786.6ACTC1, CALR, CDK4, CDKN2A, HMGA2, MDM2
10MP:00053766.1ACTC1, CALR, CDK4, CDKN2A, DES, HMGA2

Publications for Dedifferentiated Liposarcoma

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Articles related to Dedifferentiated Liposarcoma:

(show top 50)    (show all 163)
idTitleAuthorsYear
1
Seaweed floating in the pericardium: a rare case of primary dedifferentiated liposarcoma. (26525285)
2015
2
Dedifferentiated Liposarcoma of the Anterior Mediastinum: A Rare Case. (26252913)
2015
3
Dedifferentiated Liposarcoma of the Gastroesophageal Junction. (25690861)
2015
4
Immunohistochemical, cytogenetic, and molecular cytogenetic characterization of both components of a dedifferentiated liposarcoma: implications for histogenesis. (25550570)
2015
5
Primary cardiac dedifferentiated liposarcoma with homologous and heterologous differentiation: a case report. (26464734)
2015
6
Dedifferentiated liposarcoma involving the spleen and splenic hilum: a report of a case with a rare growth pattern. (25594652)
2015
7
Primary dedifferentiated liposarcoma of the lung with rhabdomyoblastic and chrondroblastic differentiation. (24612243)
2014
8
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
9
Is the nonlipomatous component of dedifferentiated liposarcoma always soft tissue on CT? Analysis of CT densities and correlation with rate of growth in 60 patients. (25287680)
2014
10
Loss of heterozygosity and microsatellite instability are rare in sporadic dedifferentiated liposarcoma: a study of 43 well-characterized cases. (24878023)
2014
11
Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases. (25126005)
2014
12
MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. (24515760)
2014
13
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component. (23426961)
2013
14
High level of CDK4 amplification is a poor prognostic factor in well-differentiated and dedifferentiated liposarcoma. (23852861)
2013
15
Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma. (23569312)
2013
16
Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. (23416162)
2013
17
Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability. (22241790)
2012
18
Dedifferentiated liposarcoma of the rectum: a case report. (23139616)
2012
19
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study. (23084521)
2012
20
Renal dedifferentiated liposarcoma with intra-caval tumor thrombus: A rare case. (22919143)
2012
21
Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. (22301498)
2012
22
Liposarcoma of the chest wall. Transformation of dedifferentiated liposarcoma from a recurrent lipoma. (22886125)
2012
23
High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma. (21793095)
2011
24
Primary (de novo) dedifferentiated liposarcoma in the extremities: a multi-institution Tohoku Musculoskeletal Tumor Society study of 18 cases in northern Japan. (21795247)
2011
25
Well-differentiated and dedifferentiated liposarcomas. (19688222)
2010
26
Dedifferentiated liposarcoma of retroperitoneum: spectrum of imaging findings in 15 patients. (20416485)
2010
27
Dedifferentiated liposarcoma of the retroperitoneum. (20369054)
2010
28
Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. (19946100)
2009
29
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura. (19589790)
2009
30
Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component: report of two cases. (19135935)
2009
31
Dedifferentiated liposarcoma in the retroperitoneum in an atomic bomb survivor: report of a case. (21490866)
2008
32
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. (18214854)
2008
33
Dedifferentiated liposarcoma presenting as jejunal polyp. Case report. (18184419)
2007
34
Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whorling pattern and metaplastic bone formation. (17213023)
2007
35
Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses. (18036404)
2007
36
Dedifferentiated liposarcoma arising from the sigmoid mesocolon: a case report. (17696239)
2007
37
alpha-fetoprotein expression in a dedifferentiated liposarcoma. (16489442)
2006
38
MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. (16160477)
2005
39
Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. (15842647)
2005
40
Primary dedifferentiated liposarcoma of the lung. (15910606)
2005
41
Alterations of the RB1 gene in dedifferentiated liposarcoma. (15933756)
2005
42
Dedifferentiated liposarcoma with extensive lymphoid component. (15991843)
2005
43
Best cases from the AFIP: Dedifferentiated liposarcoma of soft tissue with high-grade osteosarcomatous dedifferentiation. (16009825)
2005
44
Establishment of a novel human dedifferentiated liposarcoma cell line, FU-DDLS-1: conventional and molecular cytogenetic characterization. (12579306)
2003
45
Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. (12640106)
2003
46
A leukemoid reaction in a patient with a dedifferentiated liposarcoma. (11391379)
2001
47
Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. (9706974)
1998
48
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
49
Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. (9071997)
1997
50
Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. (7977944)
1994

Variations for Dedifferentiated Liposarcoma

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Expression for genes affiliated with Dedifferentiated Liposarcoma

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Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for genes affiliated with Dedifferentiated Liposarcoma

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Pathways related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3MDM2, TP53
29.3CDK4, TP53
39.0CDK4, MDM2, TP53
49.0CDK4, MDM2, TP53
59.0CDK4, MDM2, TP53
6
Show member pathways
9.0CDK4, MDM2, TP53
79.0CDK4, MDM2, TP53
8
Show member pathways
9.0CDK4, MDM2, TP53
99.0CDK4, MDM2, TP53
109.0HMGA2, MDM2, TP53
118.9CDKN2A, MDM2, TP53
12
Apoptosis (WikiPathways)
Show member pathways
8.9CDKN2A, MDM2, TP53
138.9CDKN2A, MDM2, TP53
14
Show member pathways
8.9CDKN2A, MDM2, TP53
158.9CDKN2A, MDM2, TP53
168.9CDKN2A, MDM2, TP53
17
Show member pathways
8.9CDK4, CDKN2A, TP53
18
Show member pathways
8.7MDM2, STAT6, TP53
19
Show member pathways
8.5CDK4, CDKN2A, MDM2, TP53
208.5CDK4, CDKN2A, MDM2, TP53
21
Show member pathways
8.5CDK4, CDKN2A, MDM2, TP53
22
Show member pathways
8.5CDK4, CDKN2A, MDM2, TP53
23
Show member pathways
8.5CDK4, CDKN2A, MDM2, TP53
248.5CDK4, CDKN2A, MDM2, TP53
258.5CDK4, CDKN2A, MDM2, TP53
268.5CDK4, CDKN2A, MDM2, TP53
278.5CDK4, CDKN2A, MDM2, TP53
288.5CDK4, CDKN2A, MDM2, TP53
298.5CDK4, CDKN2A, MDM2, TP53
308.5CDKN2A, HMGA2, MDM2, TP53
318.3CALR, CDK4, CDKN2A, TP53
32
Show member pathways
8.2CALR, CDK4, STAT6, TP53
33
Show member pathways
8.2CDK4, CDKN2A, HMGA2, MDM2, TP53

GO Terms for genes affiliated with Dedifferentiated Liposarcoma

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Cellular components related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:003598510.4CDKN2A, HMGA2
2nuclear bodyGO:00166049.5CDKN2A, MDM2, TP53
3protein complexGO:00432348.4CALR, CDKN2A, MDM2, TP53
4cytosolGO:00058296.2ACTC1, CALR, CDK4, CDKN2A, DES, MDM2

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:007115710.4CDK4, MDM2
2senescence-associated heterochromatin focus assemblyGO:003598610.4CDKN2A, HMGA2
3positive regulation of cellular senescenceGO:200077410.4CDKN2A, HMGA2
4negative regulation of intracellular steroid hormone receptor signaling pathwayGO:003314410.3CALR, HMGA2
5protein destabilizationGO:003164810.2CDKN2A, MDM2
6positive regulation of cell cycleGO:004578710.2CALR, MDM2
7protein localization to nucleusGO:003450410.2CALR, MDM2
8cellular senescenceGO:009039810.0CALR, CDKN2A
9response to testosteroneGO:003357410.0CALR, CDK4
10chromosome breakageGO:00310529.9HMGA2, TP53
11replicative senescenceGO:00903999.8CDKN2A, TP53
12response to antibioticGO:00466779.8MDM2, TP53
13positive regulation of cell cycle arrestGO:00711589.3CDKN2A, HMGA2, TP53
14muscle filament slidingGO:00300499.2ACTC1, DES
15positive regulation of cell proliferationGO:00082849.2CALR, CDK4, HMGA2, MDM2
16cell cycle arrestGO:00070509.1CALR, CDKN2A, TP53
17regulation of cell proliferationGO:00421278.9CDK4, STAT6, TP53
18positive regulation of apoptotic processGO:00430658.9CDK4, CDKN2A, HMGA2, TP53
19negative regulation of apoptotic processGO:00430668.8ACTC1, HMGA2, MDM2, TP53
20positive regulation of gene expressionGO:00106288.3ACTC1, CALR, HMGA2, TP53
21response to drugGO:00424938.3ACTC1, CALR, CDK4, TP53
22negative regulation of transcription, DNA-templatedGO:00458927.9CALR, CDKN2A, HMGA2, MDM2, TP53
23negative regulation of transcription from RNA polymerase II promoterGO:00001227.8CALR, HMGA2, MDM2, STAT6, TP53

Molecular functions related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.3CDKN2A, MDM2, TP53
2identical protein bindingGO:00428028.3DES, MDM2, STAT6, TP53

Sources for Dedifferentiated Liposarcoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet