DDLS
MCID: DDF001
MIFTS: 42

Dedifferentiated Liposarcoma (DDLS) malady

Cancer diseases category

Summaries for Dedifferentiated Liposarcoma

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32MalaCards
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MalaCards: Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to liposarcoma and lipoma. An important gene associated with Dedifferentiated Liposarcoma is CDK4 (cyclin-dependent kinase 4), and among its related pathways are Activation of Chaperone Genes by ATF6-alpha and Androgen receptor signaling pathway. The compounds hmba and vinblastine have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Dedifferentiated Liposarcoma

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48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
dedifferentiated liposarcoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

dedifferentiated liposarcoma 48
liposarcoma, dedifferentiated 60
ddls 48


External Ids:

ICD10 via Orphanet26 C49
SNOMED-CT via Orphanet57 404072004, 67280001
UMLS via Orphanet61 C0205824

Related Diseases for Dedifferentiated Liposarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1liposarcoma31.7PPARG, MDM2, TP53, HMGA2, CDK4, YEATS4
2lipoma30.6MDM2, DDIT3, DES, CDK4, HMGA2
3sarcoma30.5MDM2, RB1, DDIT3, DES, MUC1, CDK4
4myxoid liposarcoma30.4DDIT3
5leukemoid reaction30.3CSF3, IL3
6leiomyosarcoma30.3DES, RB1, MDM2, MUC1, CDK4, ACTC1
7pancreatitis30.1CRP
8hyperparathyroidism30.1SLPI
9hypertension30.1PPARG, CRP
10acute leukemia30.1CEBPA, IL3, CSF3
11diabetes mellitus30.1CALR, PPARG, CRP
12rhabdomyosarcoma30.1TP53, ACTC1, CDK4, DES, DDIT3, RB1
13leukemia30.1CSF3, MDM2, RB1, DDIT3, CDKN2A, CDK4
14fibrous histiocytoma10.5
15pleomorphic liposarcoma10.5
16histiocytoma10.5
17mediastinum liposarcoma10.4
18inflammatory liposarcoma10.3
19fibroblastic liposarcoma10.3
20conventional leiomyosarcoma10.3
21acute pancreatitis10.1
22liposarcoma of bone10.1
23primary hyperparathyroidism10.1
24esophagus liposarcoma10.1
25spindle cell liposarcoma10.1
26kaposi's sarcoma10.1
27paraganglioma10.1
28chest wall lipoma10.1
29pleomorphic lipoma10.1
30spindle cell lipoma10.1
31cervicitis10.1
32esophagitis10.1
33hyperthyroidism10.1
34laryngitis10.1
35retroperitoneal sarcoma10.1
36gliosarcoma10.0CDK4
37dermatofibrosarcoma10.0MDM2
38endometriosis10.0ACTC1
39hemangioma10.0ACTC1
40giant cell glioblastoma10.0MDM2
41myoepithelioma10.0ACTC1
42chondroma10.0HMGA2
43hepatitis b10.0AFP
44benign meningioma10.0MDM2
45hepatitis c10.0AFP
46hepatoblastoma10.0AFP
47hepatitis10.0AFP
48ischemia10.0CALR
49infantile myofibromatosis10.0DES
50cystic fibrosis10.0SLPI

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to dedifferentiated liposarcoma

Clinical Features for Dedifferentiated Liposarcoma

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Drugs & Therapeutics for Dedifferentiated Liposarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dedifferentiated Liposarcoma

Drug clinical trials:

Search ClinicalTrials for Dedifferentiated Liposarcoma

Search NIH Clinical Center for Dedifferentiated Liposarcoma

Search CenterWatch for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

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Anatomical Context for Dedifferentiated Liposarcoma

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Animal Models for Dedifferentiated Liposarcoma or affiliated genes

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36MGI
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Publications for Dedifferentiated Liposarcoma

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Genetic Variations for Dedifferentiated Liposarcoma

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Expression for genes affiliated with Dedifferentiated Liposarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dedifferentiated Liposarcoma

Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for genes affiliated with Dedifferentiated Liposarcoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 51QIAGEN, 29KEGG, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Dedifferentiated Liposarcoma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8DDIT3, CALR
29.8MDM2, RB1, CALR
39.8TP53, MDM2, CDK4
49.8CDK4, TP53, MDM2
5
Hide members
9.7PPARG, CDK4, IL3
69.7MDM2, TP53, AFP
79.7CDKN2A, TP53, MDM2
89.7MDM2, TP53, CDKN2A
9
Hide members
9.7TP53, CDK4, IL3
109.7RB1, CDK4, TP53
11
Hide members
9.7TP53, MDM2, RB1
12
Hide members
9.6MDM2, CDK4, CDKN2A, RB1
13
Hide members
9.6CDKN2A, CDK4, RB1, MDM2
149.6MUC1, MDM2, TP53
159.5IL3, CDK4, MDM2, TP53
169.5CEBPA, RB1, MDM2, PPARG
17
Hide members
9.5TP53, MDM2, RB1, CDK4
189.5TP53, MDM2, CDK4, RB1
19
Hide members
9.4CALR, CDK4, TP53, RB1
209.4TP53, MDM2, RB1, AFP
21
Hide members
9.4CDK4, CDKN2A, RB1, TP53
229.4TP53, RB1, MDM2, CDKN2A
239.4TP53, CDKN2A, MDM2, RB1
24
Hide members
9.4MDM2, TP53, CDKN2A, RB1
25
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9.2CDK4, CDKN2A, RB1, MDM2, TP53
26
Transcription P53 signaling pathway
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9.2RB1, MDM2, CDK4, TP53, CDKN2A
279.2CDKN2A, MDM2, TP53, CDK4, RB1
28
Hide members
9.2TP53, CDKN2A, RB1, CDK4, MDM2
299.2TP53, CDK4, CDKN2A, RB1, MDM2
309.2CEBPA, DDIT3, RB1, PPARG
319.2TP53, CDK4, CALR, CDKN2A, RB1
32
Hide members
8.8TP53, IL3, CDKN2A, RB1, MDM2, PPARG
33
Hide members
8.8CDK4, TP53, DES, RB1, MDM2, DDIT3
348.7TP53, CEBPA, CDKN2A, RB1, PPARG, MDM2
358.7IL3, CSF3, MDM2, CDK4, TP53
368.5TP53, PPARG, MDM2, DDIT3, IL3, HMGA2
37
Hide members
8.2MDM2, IL3, CEBPA, DDIT3, TP53, CSF3

Compounds for genes affiliated with Dedifferentiated Liposarcoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Dedifferentiated Liposarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1hmba4410.4CDK4
2vinblastine44 49 1112.0TP53, AFP, MDM2
3serine449.9DES, AFP, FRS2
4glycogen44 2410.7MDM2, AFP, CDK4, ACTC1, CEBPA
5olomoucine44 1110.6TP53, CDK4, CDKN2A, RB1
6roscovitine449.5MDM2, RB1, CDKN2A, CDK4, TP53
7aflatoxin b144 2410.5MDM2, RB1, CDKN2A, TP53
8flavopiridol44 1110.5MDM2, RB1, CDKN2A, CDK4, TP53
9paraffin449.3MDM2, DES, AFP, MUC1, CDK4, HMGA2
10vincristine44 49 1111.3CSF3, RB1, AFP, IL3
11biotin44 11 2411.2CRP, RB1, DES, MUC1, CDKN2A, ACTC1
12adpribose449.2MDM2, RB1, DES, CDK4, TP53
13h2o2449.1RB1, DDIT3, DES, AFP, CDKN2A, IL3
14creatinine449.1CRP, AFP, CDKN2A, SLPI, ACTC1
15hematoxylin449.1DES, MUC1, CDKN2A, SLPI, ACTC1
16agar449.1MDM2, RB1, AFP, MUC1, CDKN2A, CDK4
17estradiol44 11 2410.9MDM2, RB1, DES, AFP, CDK4, SLPI
18ly294002448.9PPARG, MDM2, CRP, RB1, CDK4, IL3
19irinotecan44 49 1110.8CSF3, MDM2, AFP, CDKN2A, TP53
20valine448.8CSF3, MDM2, AFP, CDKN2A, CDK4, IL3
21dexamethasone44 49 28 1111.7CALR, MDM2, RB1, AFP, CDKN2A, CDK4
22progesterone44 59 28 11 2412.6MDM2, RB1, DES, AFP, MUC1, CDKN2A
23etoposide44 49 59 1111.6CSF3, MDM2, RB1, DDIT3, AFP, IL3
24n acetylcysteine448.5CALR, PPARG, CRP, DDIT3, CDKN2A, CDK4
25cytarabine44 49 1110.5CSF3, RB1, MUC1, CDKN2A, IL3, TP53
26docetaxel44 49 59 1111.5CSF3, MDM2, DDIT3, CDKN2A, IL3, TP53
27glucose448.5PPARG, DDIT3, MUC1, CDKN2A, SLPI, ACTC1
28steroid448.4CALR, MDM2, RB1, DES, AFP, CDKN2A
29cyclophosphamide44 49 1110.4CSF3, MDM2, CRP, RB1, AFP, IL3
30methotrexate44 49 1110.4CSF3, MDM2, CRP, RB1, AFP, MUC1
31paclitaxel44 49 1110.3CSF3, MDM2, RB1, AFP, CDKN2A, CDK4
32genistein44 28 59 2 11 2413.3PPARG, MDM2, RB1, DDIT3, CDKN2A, CDK4
33oligonucleotide448.1MDM2, RB1, AFP, CDKN2A, CDK4, SLPI
34carboplatin44 49 1110.1CSF3, MDM2, RB1, DDIT3, AFP, CDK4
35threonine448.1CALR, MDM2, RB1, DES, AFP, MUC1
36iron44 249.0CALR, MDM2, CRP, DDIT3, DES, AFP
37nitric oxide44 11 2410.0CALR, MDM2, RB1, DDIT3, DES, MUC1
38adriamycin448.0CSF3, MDM2, RB1, DES, AFP, MUC1
395fluorouracil447.9CSF3, MDM2, RB1, AFP, MUC1, CDKN2A
40doxorubicin44 49 119.9CSF3, MDM2, RB1, DES, AFP, CDKN2A
41oxygen44 248.8CALR, MDM2, RB1, DDIT3, DES, AFP
42calcium44 49 11 2410.6CALR, CRP, DDIT3, DES, AFP, MUC1
43cysteine447.6CALR, MDM2, RB1, DES, MUC1, CDKN2A
44actinomycin d447.5MDM2, RB1, DDIT3, DES, AFP, MUC1
45thymidine44 248.4DES, RB1, MDM2, CSF3, AFP, MUC1
46testosterone44 59 11 249.8CALR, PPARG, MDM2, CRP, RB1, DDIT3
47cisplatin44 49 59 119.7SLPI, TP53, HMGA2, IL3, CSF3, MDM2
48tyrosine446.3DDIT3, RB1, MDM2, CSF3, CALR, DES
49vegf446.1TP53, ACTC1, SLPI, CSF3, PPARG, MDM2
50retinoic acid44 246.7TP53, CALR, CSF3, PPARG, RB1, DDIT3

GO Terms for genes affiliated with Dedifferentiated Liposarcoma

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16Gene Ontology
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Cellular components related to Dedifferentiated Liposarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focusGO:03598510.0HMGA2, CDKN2A
2Rb-E2F complexGO:0351899.9CEBPA, RB1
3nuclear bodyGO:0166049.8MDM2, CDKN2A, TP53
4nuclear matrixGO:0163639.5CEBPA, YEATS4, TP53
5chromatinGO:0007859.4RB1, CDK4, TP53
6nucleoplasmGO:0056548.2PPARG, MDM2, RB1, DDIT3, YEATS4, CDKN2A

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1senescence-associated heterochromatin focus assemblyGO:03598610.3HMGA2, CDKN2A
2positive regulation of cellular senescenceGO:200077410.2HMGA2, CDKN2A
3cellular response to lithium ionGO:07128510.0PPARG, CEBPA, CALR
4organ regenerationGO:03110010.0CDK4, PPARG, CEBPA
5positive regulation of cell cycle arrestGO:07115810.0CDKN2A, TP53, HMGA2
6replicative senescenceGO:0903999.9TP53, CDKN2A
7response to lead ionGO:0102889.9CDK4, CRP
8DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.7MDM2, MUC1, TP53
9ER overload responseGO:0069839.7DDIT3, TP53
10Ras protein signal transductionGO:0072659.7TP53, RB1, CDKN2A
11white fat cell differentiationGO:0508729.7CEBPA, PPARG
12response to drugGO:0424939.6PPARG, CALR, MDM2, CDK4, ACTC1
13negative regulation of transcription from RNA polymerase II promoterGO:0001229.3MDM2, HMGA2, CEBPA, TP53, CALR, PPARG
14cell cycle arrestGO:0070509.2TP53, CALR, RB1, DDIT3, CDKN2A
15positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2CSF3, IL3, TP53
16positive regulation of cell proliferationGO:0082849.0CDK4, MDM2, CALR, IL3, CSF3
17negative regulation of transcription, DNA-dependentGO:0458928.6TP53, CALR, PPARG, MDM2, HMGA2, RB1
18positive regulation of transcription, DNA-dependentGO:0458938.5YEATS4, DDIT3, RB1, PPARG, CDKN2A, TP53
19positive regulation of transcription from RNA polymerase II promoterGO:0459447.9TP53, CEBPA, HMGA2, CSF3, PPARG, RB1

Molecular functions related to Dedifferentiated Liposarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.6TP53, CDKN2A
2p53 bindingGO:0020399.4CDKN2A, MUC1, MDM2, TP53
3transcription factor bindingGO:0081348.8TP53, RB1, DDIT3, CDKN2A, HMGA2, CEBPA
4sequence-specific DNA binding transcription factor activityGO:0037008.5TP53, CEBPA, YEATS4, DDIT3, RB1, PPARG
5enzyme bindingGO:0198998.2CSF3, PPARG, SLPI, MDM2, TP53
6DNA bindingGO:0036777.7RB1, HMGA2, PPARG, CALR, YEATS4, CDKN2A
7protein bindingGO:0055155.5DDIT3, PPARG, MDM2, RB1, TP53, CEBPA

Products for genes affiliated with Dedifferentiated Liposarcoma

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Sources for Dedifferentiated Liposarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet