MCID: DDF001
MIFTS: 47

Dedifferentiated Liposarcoma

Categories: Rare diseases

Aliases & Classifications for Dedifferentiated Liposarcoma

MalaCards integrated aliases for Dedifferentiated Liposarcoma:

Name: Dedifferentiated Liposarcoma 55
Liposarcoma, Dedifferentiated 69
Liposarcoma Dedifferentiated 51
Ddls 55

Characteristics:

Orphanet epidemiological data:

55
dedifferentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 55 ORPHA99970
UMLS via Orphanet 70 C0205824
ICD10 via Orphanet 33 C49.9
UMLS 69 C0205824

Summaries for Dedifferentiated Liposarcoma

MalaCards based summary : Dedifferentiated Liposarcoma, also known as liposarcoma, dedifferentiated, is related to histiocytoma and liposarcoma. An important gene associated with Dedifferentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Endometrial cancer. The drugs Rosiglitazone and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and colon, and related phenotypes are cardiovascular system and cellular

Related Diseases for Dedifferentiated Liposarcoma

Diseases related to Dedifferentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 30.5 CDK4 MDM2 TP53
2 liposarcoma 30.3 CDK4 CDKN2A DES HMGA2 MDM2 TP53
3 fibrous histiocytoma 30.1 ACTC1 DES F13A1
4 well-differentiated liposarcoma 30.0 CDK4 CDKN2A HMGA2 MDM2
5 lipomatosis, multiple 30.0 CDK4 DES HMGA2 MDM2
6 atypical lipomatous tumor 29.8 CDK4 CDKN2A HMGA2 MDM2
7 rhabdomyosarcoma 29.8 CDK4 DES MDM2 TP53
8 pleomorphic liposarcoma 29.7 ACTC1 CDKN2A DES MDM2
9 hemangiopericytoma, malignant 29.6 ACTC1 DES F13A1 MDM2
10 inflammatory myofibroblastic tumor 29.6 ACTC1 DES MDM2 TP53
11 leiomyosarcoma 29.4 ACTC1 CDK4 DES MDM2 TP53
12 myxoid liposarcoma 29.4 CDK4 HMGA2 MDM2 TP53
13 malignant peripheral nerve sheath tumor 29.0 ACTC1 CDK4 CDKN2A MDM2 TP53
14 undifferentiated embryonal sarcoma of the liver 10.5 CDK4 MDM2
15 extraosseous osteosarcoma 10.5 CDK4 MDM2
16 inflammatory mfh 10.5 CDK4 MDM2
17 bone osteosarcoma 10.5 CDK4 MDM2
18 lipoblastoma 10.5 CDK4 MDM2
19 mixed liposarcoma 10.4 CDK4 MDM2
20 spindle cell liposarcoma 10.4 CDK4 MDM2
21 chondroid lipoma 10.4 CDK4 MDM2
22 actinic cheilitis 10.4 MDM2 TP53
23 juxtacortical osteosarcoma 10.4 CDK4 MDM2
24 sclerosing liposarcoma 10.4 MDM2 TP53
25 lip cancer 10.4 MDM2 TP53
26 plasmablastic lymphoma 10.3 CDKN2A DES
27 brain stem astrocytic neoplasm 10.3 CDKN2A TP53
28 squamous cell carcinoma of the oropharynx 10.3 CDKN2A TP53
29 spitz nevus 10.3 CDKN2A TP53
30 ewing's family of tumors 10.3 CDK4 CDKN2A
31 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
32 squamous cell carcinoma of the larynx 10.3 CDKN2A TP53
33 gliomatosis cerebri 10.3 MDM2 TP53
34 bartholin's gland benign neoplasm 10.3 CDKN2A TP53
35 ovarian fibrothecoma 10.3 ACTC1 DES
36 soft tissue sarcoma 10.3 MDM2 TP53
37 cutaneous leiomyosarcoma 10.3 ACTC1 DES
38 bladder carcinoma in situ 10.3 CDKN2A TP53
39 peripheral osteosarcoma 10.3 CDK4 MDM2
40 malignant ectomesenchymoma 10.3 DES HMGA2
41 ectomesenchymoma 10.3 DES HMGA2
42 thyroid lymphoma 10.3 CDKN2A TP53
43 parachordoma 10.3 ACTC1 DES
44 vulva squamous cell carcinoma 10.3 CDKN2A TP53
45 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
46 uterine sarcoma 10.3 DES MDM2
47 ossifying fibromyxoid tumor 10.3 ACTC1 DES
48 epithelioid leiomyosarcoma 10.3 ACTC1 DES
49 pulmonary blastoma 10.3 DES TP53
50 bone squamous cell carcinoma 10.3 CDKN2A TP53

Graphical network of the top 20 diseases related to Dedifferentiated Liposarcoma:



Diseases related to Dedifferentiated Liposarcoma

Symptoms & Phenotypes for Dedifferentiated Liposarcoma

MGI Mouse Phenotypes related to Dedifferentiated Liposarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 ACTC1 CDK4 CDKN2A DES F13A1 MDM2
2 cellular MP:0005384 10 ACTC1 CDK4 CDKN2A DES MDM2 MET
3 homeostasis/metabolism MP:0005376 9.97 ACTC1 CDK4 CDKN2A DES F13A1 MDM2
4 endocrine/exocrine gland MP:0005379 9.88 MET TP53 CDK4 CDKN2A F13A1 MDM2
5 mortality/aging MP:0010768 9.86 ACTC1 CDK4 CDKN2A DES F13A1 MDM2
6 digestive/alimentary MP:0005381 9.83 CDK4 CDKN2A MDM2 MET TP53
7 liver/biliary system MP:0005370 9.72 CDK4 CDKN2A MDM2 MET TP53
8 muscle MP:0005369 9.7 ACTC1 CDK4 CDKN2A DES MDM2 MET
9 neoplasm MP:0002006 9.35 CDKN2A MDM2 MET TP53 CDK4
10 pigmentation MP:0001186 8.92 CDK4 CDKN2A MDM2 TP53

Drugs & Therapeutics for Dedifferentiated Liposarcoma

Drugs for Dedifferentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
2
Ifosfamide Approved Phase 2 3778-73-2 3690
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
5
Mesna Approved, Investigational Phase 2 3375-50-6 598
6
Everolimus Approved Phase 2 159351-69-6 6442177
7
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
8
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
9
nivolumab Approved Phase 2 946414-94-4
10
Pembrolizumab Approved Phase 2 1374853-91-4
11
Maleic acid Experimental Phase 2 110-16-7 444266
12 Hypoglycemic Agents Phase 2
13 Isophosphamide mustard Phase 2 0
14 Alkylating Agents Phase 2
15 Antibodies, Monoclonal Phase 2
16 Anti-Bacterial Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Antifungal Agents Phase 2
19 Immunoglobulins Phase 2
20 Immunosuppressive Agents Phase 2
21 Antibiotics, Antitubercular Phase 2
22 Antibodies Phase 2

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Selinexor in Advanced Liposarcoma Recruiting NCT02606461 Phase 2, Phase 3 Selinexor;Placebo
2 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
3 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
4 Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) Recruiting NCT03114527 Phase 2 Ribociclib;Everolimus
5 Study of Abemaciclib in Dedifferentiated Liposarcoma Recruiting NCT02846987 Phase 2 Abemaciclib
6 A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Recruiting NCT03096912 Phase 2 Ribociclib
7 Ph II Cabazitaxel DD Liposarcoma Recruiting NCT01913652 Phase 2 Cabazitaxel;Prolonged infusional ifosfamide
8 Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Recruiting NCT02247544 Phase 2 Trabectedin
9 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
10 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
11 Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery Recruiting NCT02500797 Phase 2
12 A Phase II Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Active, not recruiting NCT02571829 Phase 2 ribociclib
13 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
14 Study Evaluating the Efficacy and Safety of IPI 504 in Patients With Advanced Dedifferentiated Liposarcoma Withdrawn NCT00969917 Phase 2 IPI-504
15 Phase 1 Safety Testing of SAR405838 Active, not recruiting NCT01636479 Phase 1 SAR405838
16 The FGF/FGFR Signalling Pathway: Recruiting NCT03303885

Search NIH Clinical Center for Dedifferentiated Liposarcoma

Genetic Tests for Dedifferentiated Liposarcoma

Anatomical Context for Dedifferentiated Liposarcoma

MalaCards organs/tissues related to Dedifferentiated Liposarcoma:

38
Bone, Testes, Colon, Lung, Liver, Lymph Node, Kidney

Publications for Dedifferentiated Liposarcoma

Articles related to Dedifferentiated Liposarcoma:

(show top 50) (show all 215)
# Title Authors Year
1
Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. ( 29309298 )
2018
2
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. ( 29446522 )
2018
3
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
4
Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithelioid cells: a frequently misdiagnosed highly aggressive variant. ( 29307627 )
2018
5
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
6
Frequent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma. ( 28099935 )
2017
7
Systemic Therapy in Metastatic or Unresectable Well-Differentiated/Dedifferentiated Liposarcoma. ( 29250486 )
2017
8
Malignant solitary fibrous tumour of the kidney with lymph node and liver metastases: beware of STAT6 expression in dedifferentiated liposarcoma with a solitary fibrous tumour-like morphology: author reply. ( 28838615 )
2017
9
p16 Immunohistochemistry is Less Useful Than MDM2 and CDK4 to Distinguish Dedifferentiated Liposarcomas From Other Retroperitoneal Mimics. ( 26509911 )
2017
10
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
11
Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. ( 29076540 )
2017
12
Dedifferentiated liposarcoma of the lower extremity with low-grade dedifferentiation and low-grade osteosarcomatous component. ( 27909788 )
2017
13
Giant retroperitoneal dedifferentiated liposarcoma. ( 28098568 )
2017
14
Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass. ( 28950740 )
2017
15
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. ( 28552535 )
2017
16
Malignant solitary fibrous tumour of the kidney with lymph node and liver metastases: beware of STAT6 expression in dedifferentiated liposarcoma with a solitary fibrous tumour-like morphology. ( 28822554 )
2017
17
A retroperitoneal dedifferentiated liposarcoma mimicking an ovarian tumor. ( 29184870 )
2017
18
Preoperative Radiation Therapy With Simultaneous Integrated Boost Dose Escalation for Optimal Local Control of Retroperitoneal Dedifferentiated Liposarcoma. ( 28463146 )
2017
19
A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. ( 29046788 )
2017
20
Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard. ( 28928422 )
2017
21
A case of dedifferentiated liposarcoma of the heart and stomach. ( 29031176 )
2017
22
Scattered genomic amplification in dedifferentiated liposarcoma. ( 28652867 )
2017
23
Identification of key genes and molecular mechanisms associated with dedifferentiated liposarcoma based on bioinformatic methods. ( 28670134 )
2017
24
Dedifferentiated Liposarcoma in the Spermatic Cord Finally Diagnosed at 7th Resection of Recurrence: A Case Report and Bibliographic Consideration. ( 28878655 )
2017
25
High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. ( 29153098 )
2017
26
Primary colonic well-differentiatedA /A dedifferentiated liposarcoma of the ascending colon: a case report. ( 28856628 )
2017
27
Retroperitoneal dedifferentiated liposarcoma with huge cystic degeneration: A case report. ( 28337832 )
2017
28
Dedifferentiated Liposarcoma With Epithelioid/Epithelial Features. ( 28719466 )
2017
29
Mediastinal dedifferentiated liposarcoma. ( 28707566 )
2017
30
Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report. ( 29209735 )
2017
31
Dedifferentiated Liposarcoma of the Esophagus: A Case Report and Selected Review of the Literature. ( 28191296 )
2016
32
Application of MDM2 Fluorescence In Situ Hybridization and Immunohistochemistry in Distinguishing Dedifferentiated Liposarcoma From Other High-grade Sarcomas. ( 27028243 )
2016
33
Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial. ( 27124835 )
2016
34
Dedifferentiated Liposarcoma of Sigmoid Mesocolon - A Case Report. ( 27604671 )
2016
35
Homologous Lipoblastic Differentiation in Dedifferentiated Liposarcoma. ( 26644373 )
2016
36
Paratesticular dedifferentiated liposarcoma with rhabdomyoblastic differentiation and hCG production: Case study and literature review. ( 27773101 )
2016
37
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma. ( 27409346 )
2016
38
Dedifferentiated Liposarcoma Masquerading as Rhabdomyosarcoma. ( 27801731 )
2016
39
Primary mediastinal dedifferentiated liposarcoma resected by lateral thoracotomy with video-assisted thoracoscopic surgery. ( 26724326 )
2016
40
Giant dedifferentiated liposarcoma of small bowel mesentery: a case report. ( 27654578 )
2016
41
Multiple Primary Dedifferentiated Liposarcoma of the Jejunal Mesentery: A Case Report and Review of Literature. ( 26894164 )
2016
42
Primary Diaphragmatic Dedifferentiated Liposarcoma in a Young Female Patient after Delivery. ( 27247814 )
2016
43
Spermatic cord dedifferentiated liposarcoma presenting as a recurrent inguinal hernia. ( 27995856 )
2016
44
Dedifferentiated Liposarcoma: Updates on Morphology, Genetics, and Therapeutic Strategies. ( 26645460 )
2016
45
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2016
46
MDM2 Expression in Extranodal Abdominal and Retroperitoneal Follicular Dendritic Cell Sarcomas, Mimicking Dedifferentiated Liposarcomas. ( 26180935 )
2016
47
Rare Aggressive Behavior of MDM2-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases. ( 27746879 )
2016
48
Plasma levels of miRNA-155 as a powerful diagnostic marker for dedifferentiated liposarcoma. ( 27186423 )
2016
49
Clinical outcome of dedifferentiated liposarcoma in the extremities: A retrospective case series of 7 patients. ( 27317086 )
2016
50
The hepatocyte growth factor receptor as a potential therapeutic target for dedifferentiated liposarcoma. ( 26006023 )
2015

Variations for Dedifferentiated Liposarcoma

Expression for Dedifferentiated Liposarcoma

Search GEO for disease gene expression data for Dedifferentiated Liposarcoma.

Pathways for Dedifferentiated Liposarcoma

Pathways related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CDK4 CDKN2A HMGA2 MDM2 TP53
2
Show member pathways
12.88 CDK4 CDKN2A MDM2 MET TP53
3
Show member pathways
12.8 CDK4 MDM2 MET TP53
4 12.66 CDK4 CDKN2A MDM2 MET TP53
5
Show member pathways
12.61 CDK4 CDKN2A MET TP53
6
Show member pathways
12.44 CDK4 CDKN2A MDM2 TP53
7
Show member pathways
12.44 CDK4 CDKN2A MDM2 TP53
8 12.37 CDK4 CDKN2A MDM2 TP53
9 12.26 CDK4 CDKN2A TP53
10
Show member pathways
12.24 MDM2 MET TP53
11
Show member pathways
12.23 CDK4 CDKN2A MDM2 TP53
12 12.22 CDK4 CDKN2A MDM2 TP53
13
Show member pathways
12.2 CDK4 CDKN2A TP53
14 12.15 MDM2 MET TP53
15 12.13 CDK4 CDKN2A MDM2 TP53
16
Show member pathways
12.11 CDK4 MDM2 TP53
17
Show member pathways
12.08 CDK4 MDM2 MET TP53
18 12.05 HMGA2 MDM2 MET TP53
19 12.03 CDKN2A HMGA2 MDM2 MET TP53
20 12.01 CDK4 MDM2 TP53
21 11.96 CDK4 CDKN2A MDM2 TP53
22 11.94 MDM2 MET TP53
23
Show member pathways
11.92 CDK4 CDKN2A MDM2 TP53
24 11.91 CDKN2A MDM2 TP53
25 11.87 CDKN2A MDM2 TP53
26 11.83 CDKN2A MDM2 TP53
27 11.83 CDK4 CDKN2A MDM2 TP53
28 11.73 CDK4 MDM2 TP53
29 11.62 CDKN2A MDM2 TP53
30
Show member pathways
11.62 CDKN2A MDM2 TP53
31 11.6 CDK4 CDKN2A MDM2 TP53
32 11.46 CDKN2A MDM2 TP53
33 11.35 CDK4 MDM2 TP53
34 11.31 CDK4 MDM2 TP53
35 11.29 ACTC1 MET
36 11.17 CDK4 TP53
37 11.16 MDM2 TP53
38 11.12 CDK4 CDKN2A MDM2 TP53
39 10.89 CDKN2A MDM2 TP53
40
Show member pathways
10.84 CDKN2A MDM2 TP53
41 10.43 CDK4 CDKN2A MDM2 TP53

GO Terms for Dedifferentiated Liposarcoma

Cellular components related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.13 CDK4 HMGA2 TP53
2 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.88 CDK4 CDKN2A HMGA2 TP53
2 negative regulation of transcription, DNA-templated GO:0045892 9.83 CDKN2A HMGA2 MDM2 TP53
3 negative regulation of apoptotic process GO:0043066 9.81 ACTC1 HMGA2 MDM2 TP53
4 positive regulation of apoptotic process GO:0043065 9.71 CDK4 CDKN2A HMGA2 TP53
5 response to drug GO:0042493 9.62 ACTC1 CDK4 MDM2 TP53
6 muscle filament sliding GO:0030049 9.59 ACTC1 DES
7 base-excision repair GO:0006284 9.58 HMGA2 TP53
8 response to antibiotic GO:0046677 9.57 MDM2 TP53
9 positive regulation of cell cycle arrest GO:0071158 9.56 HMGA2 TP53
10 cellular response to gamma radiation GO:0071480 9.55 MDM2 TP53
11 negative regulation of cell cycle arrest GO:0071157 9.54 CDK4 MDM2
12 response to hyperoxia GO:0055093 9.49 CDK4 TP53
13 positive regulation of protein export from nucleus GO:0046827 9.48 MDM2 TP53
14 positive regulation of cellular senescence GO:2000774 9.46 CDKN2A HMGA2
15 replicative senescence GO:0090399 9.43 CDKN2A TP53
16 amyloid fibril formation GO:1990000 9.37 CDKN2A MDM2
17 cellular response to actinomycin D GO:0072717 9.26 MDM2 TP53
18 senescence-associated heterochromatin focus assembly GO:0035986 9.16 CDKN2A HMGA2
19 positive regulation of cell cycle GO:0045787 9.13 CDK4 MDM2 TP53
20 positive regulation of gene expression GO:0010628 9.02 ACTC1 CDKN2A HMGA2 MDM2 TP53

Molecular functions related to Dedifferentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.96 CDKN2A MDM2
2 disordered domain specific binding GO:0097718 8.8 CDKN2A MDM2 TP53

Sources for Dedifferentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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