Deep Vein Thrombosis malady

MedlinePlus: Deep vein thrombosis, or dvt, is a blood clot that forms in a vein deep in the body. most deep vein clots occur in the lower leg or thigh. if the vein swells, the condition is called thrombophlebitis. a deep vein thrombosis can break loose and cause a serious problem in the lung, called a pulmonary embolism. sitting still for a long time can make you more likely to get a dvt. some medicines and disorders that increase your risk for blood clots can also lead to dvts. common symptoms are warmth and tenderness over the vein pain or swelling in the part of the body affected skin redness treatment includes medicines to ease pain and inflammation, break up clots and keep new clots from forming. keeping the affected area raised and applying moist heat can also help. if you are taking a long car or plane trip, take a break, walk or stretch your legs and drink plenty of liquids.²³

MalaCards: Deep Vein Thrombosis is related to thrombosis and pulmonary embolism. An important gene associated with Deep Vein Thrombosis is CTEPH1 (Pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to), and among its related pathways are Gamma-carboxylation of protein precursors and Common Pathway. The compounds fondaparinux and Drotrecogin alfa have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, liver and lung, and related mouse phenotypes are embryogenesis and hematopoietic system.

CDC: DVT/PE are often underdiagnosed and serious, but preventable medical conditions. It is important to know about DVT because it can happen to anybody at any age and can cause serious illness, disability, and in some cases, death. The good news is that DVT is preventable and treatable if discovered early.²

Wikipedia: Deep vein thrombosis, or deep venous thrombosis, (DVT) is the formation of a blood clot in a deep...⁴⁴ more...

deep vein thrombosis 17 32 23 43

Diseases related to deep vein thrombosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 704)

id	Related Disease	Score	Top Affiliating Genes
1	thrombosis	41.5	MTHFR, FGB, F8, F5, F2, CTEPH1
2	pulmonary embolism	32.9	SERPINC1, SERPINE1, VKORC1, MTHFR, CELSR2, FGA
3	postphlebitic syndrome	32.9	SERPINC1, F5, DES
4	protein s deficiency	32.7	SERPINC1, SERPINE1, MTHFR, CELSR2, FGA, APOH
5	antithrombin iii deficiency	32.3	SERPINC1, MTHFR, FGA, APOH, F5, F2
6	antiphospholipid syndrome	31.5	APOH, F2
7	type 1 von willebrand disease	31.1	VWF, MTHFR, F8
8	behcet's disease	30.8	APOH, F5, HLA-A, HLA-B, TNF, CRP
9	growth hormone deficiency	30.5	SERPINE1, F2, TNF, PROC, EPO
10	factor xi deficiency	30.4	VWF, F9, F8, F5, F3, F2
11	von willebrand's disease	30.2	VWF, SELP, F9, F8, F5, F3
12	klinefelter's syndrome	29.8	SERPINE1, MTHFR, F5, TNF, CRP, EPO
13	thromboembolism	29.7	VWF, SELP, SERPINC1, SERPINE1, MTHFR, MTR
14	protein c deficiency	29.1	SERPINC1, SERPINE1, MTHFR, FGA, APOH, F9
15	thrombophilia	28.9	VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
16	venous thrombosis	28.8	VWF, SELP, SERPINC1, SERPINE1, MTHFR, MTR
17	hyperhomocysteinemia	28.8	VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
18	polycythemia vera	28.4	VWF, SELP, SERPINC1, SERPINE1, ITGB3, F5
19	spinal cord injury	27.4	SERPINC1, SERPINE1, MTHFR, FGA, GPT, F8
20	sepsis	26.7	SELP, SERPINC1, SERPINE1, FGA, F9, F5
21	nephrotic syndrome	23.8	VWF, SELP, SERPINC1, SERPINE1, FGA, APOH
22	pulmonary hypertension	22.7	VWF, SELP, SERPINC1, SERPINE1, MTR, FGA
23	hypertension	18.4	VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
24	breast cancer	18.0	VWF, SELP, SERPINC1, SERPINE1, MTRR, MTHFR
25	placental infarction	13.9	SERPINC1, APOH, F5
26	sagittal sinus thrombosis	13.9	SERPINC1, F5, F3
27	placental abruption	13.9	SERPINC1, MTHFR, F5
28	blood protein disease	13.9	MTHFR, F5, F2
29	prothrombin deficiency	13.9	F9, F3, F2
30	porencephaly	13.8	MTHFR, F5, F2
31	acute fatty liver of pregnancy	13.8	SERPINC1, F3, F2
32	neonatal stroke	13.8	SERPINE1, MTHFR, F5
33	hepatic vein thrombosis	13.8	SERPINE1, MTHFR, F5
34	amaurosis fugax	13.8	SERPINE1, MTHFR, APOH, F5
35	scott syndrome	13.8	F5, F2, F10, TNXA
36	fournier gangrene	13.8	SERPINC1, F8, F3, F2
37	legg-calve-perthes disease	13.8	SERPINC1, SERPINE1, F5, THBD
38	carotid artery occlusion	13.8	APOH, F8, THBD
39	factor x deficiency	13.8	F9, F5, F3, F2, F10
40	spinal cord infarction	13.8	SERPINC1, MTHFR, APOH, F5, F2
41	mondor disease	13.8	APOH, F5
42	transient cerebral ischemia	13.8	MTHFR, FGA, APOH
43	factor v deficiency	13.7	F9, F8, F5, F3, F2
44	stroke, ischemic	13.7	F5, F2
45	central serous chorioretinopathy	13.7	SERPINE1, PLAT
46	dysprothrombinemia	13.7	F2, F10
47	vein disease	13.7	SERPINC1, MTHFR, F5, F2, PROS1, PROC
48	factor xii deficiency	13.7	F5, F3, F2, F13A1
49	genee-wiedemann syndrome	13.7	PLAT, THBD
50	cerebral hemorrhage	13.7	MTHFR, APOH, F2, PLAT

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to deep vein thrombosis:

²²

MGI Mouse Phenotypes related to deep vein thrombosis:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryogenesis phenotype	MP:0005380	9.9	PROCR, TNFRSF1A, CBS, F2, SERPINC1
2	hematopoietic system phenotype	MP:0005397	9.9	F11, F13A1, PROCR, EPO, HGF
3	respiratory system phenotype	MP:0005388	9.7	SELP, ITGB3, CBS, F11, F13A1
4	integument phenotype	MP:0010771	9.3	F2, PROS1, PTGS1, F3, F5, CBS
5	liver/biliary system phenotype	MP:0005370	9.2	EPO, SERPINC1, FGA, F9, CBS, F11
6	reproductive system phenotype	MP:0005389	8.8	PLG, PTGS1, CELSR2, F8, CBS, F10
7	renal/urinary system phenotype	MP:0005367	8.8	PTGS1, NOS3, PLG, SELP, CBS, ESR1
8	immune system phenotype	MP:0005387	8.6	TNFRSF1A, TNF, F11, F2, F8, F9
9	skeleton phenotype	MP:0005390	8.3	MTHFR, ITGB3, FGA, ESR1, ESR2, TNFRSF1A
10	nervous system phenotype	MP:0003631	8.2	VWF, PLG, PLAU, TNFRSF1A, ESR2, SERPINC1
11	digestive/alimentary phenotype	MP:0005381	8.1	VWF, NOS3, PLG, PLAU, PLAT, PTGS1
12	vision/eye phenotype	MP:0005391	7.8	ITGB3, FGA, F3, CBS, TNFRSF1A, PLAT
13	behavior/neurological phenotype	MP:0005386	7.4	TNFRSF1A, PLAT, NOS3, ACE, DES, PROC
14	tumorigenesis	MP:0002006	7.1	TNF, TNFRSF1A, PTGS1, PLAU, PLG, ACE
15	growth/size phenotype	MP:0005378	7.1	F3, SELP, THBD, SERPINE1, MTRR, ESR2
16	muscle phenotype	MP:0005369	7.0	F11, CBS, F3, ITGB3, ESR1, PLAU
17	mortality/aging	MP:0010768	6.1	VWF, SELP, SERPINC1, NOS3, ACE, THBD
18	cellular phenotype	MP:0005384	5.1	F2, F3, ITGB3, SELP, VWF, NFKB1
19	cardiovascular system phenotype	MP:0005385	4.1	DES, ACE, KLKB1, NOS3, PLG, PLAU
20	homeostasis/metabolism phenotype	MP:0005376	3.1	VKORC1, TNFRSF1A, PTGS1, CRP, PLAT, PLAU

Articles related to deep vein thrombosis:

(show top 50)    (show all 177)

id	Title	Authors	Year	Affiliating Genes
1	Patients with severe factor XI deficiency have a redu ced incidence of deep-vein thrombosis. (21057700)	Salomon O.... Seligsohn U.	2011	F11
2	Circulating tissue factor and microparticles are not increased in patients with deep vein thrombosis. (21500176)	Steppich B.A.... Ott I.	2011	F3
3	Deep vein thrombosis, inferior vena cava interruption and multiple thrombophilic gene mutations. (21642818)	Galati G.... Picardi A.	2011	SERPINE1, F5, MTHFR
4	Genetic analysis of patients with deep vein thrombosi s during pregnancy and postpartum. (21811774)	Neki R.... Miyata T.	2011	PROS1
5	Recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR- 677C>T and 1298A>C. (20449891)	Angel J.R.... Atallah E.	2010	MTHFR
6	Different risk of deep vein thrombosis and pulmonary embolism in carriers with factor V Leiden compared with non-carriers, but not i n other thrombophilic defects. Results from a large retrospective family cohort study. (20007142)	MAokelburg A.B.... Lijfering W.M.	2010	F5
7	The association of protein S Tokushima-K196E with a r isk of deep vein thrombosis. (20811787)	Ikejiri M.... Nobori T.	2010	F2, CYP2C9, F5
8	Lack of association between hemorheological alterations and upper-extremity deep vein thrombosis. (19318721)	Vaya A.... Corella D.	2009	F2, F5
9	Factor V Leiden is associated with more distal location of deep vein thrombosis of the leg. (18182032)	Huisman M.V.... Prandoni P.	2008	F5
10	Deep vein thrombosis of lower extremity: direct intraclot injection of alteplase once daily with systemic anticoagulation--results of pilot study. (18227550)	Chang R.... Horne M.K.	2008	PLAT
11	Congenital hypoplasia of the inferior vena cava and inherited thrombophilia: rare associated risk factors for idiopathic deep vein thrombosis. A case report. (18268431)	Bianchi M.... Castiglioni M.G.	2008	SERPINC1
12	D-dimer and factor VIII are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. (18304616)	Cosmi B.... Palareti G.	2008	F8
13	Combined heterozygote factor V Leiden mutation and an ticardiolipin antibody positivity in a young patient with spontaneous deep vein thrombosis. (18258541)	KaradurmuA9 N.... ErikAsi S.	2008	F5, APOH
14	Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. (17576867)	Agnelli G.... Schellong S.	2007	F10
15	Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis. (17439632)	Van Hylckama Vlieg A.... Hermida J.	2007	PROCR
16	Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians. (17287626)	Naushad S.... Devi A.R.	2007	F2, F5, MTHFR
17	Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population. (16507317)	Sugiyama S.... Miyata T.	2007	THBD, SULT1A3
18	Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)	Gustavsson P.... Dahl N.	2006	PROC
19	A case report of posttraumatic deep vein thrombosis of the lower limbs in a patient with factor V Leiden mutation and the congenital absence of the inferior vena cava (17078493)	Jendrzejewski J.... Wyrzykowski B.	2006	F5
20	Up close and personal with deep vein thrombosis. (16565527)	Parnell L.K.	2006	F5
21	Association of 4G/5G polymorphism in PAI1 promoter with PAI1 level in deep vein thrombosis. (16331557)	Chen Y.L.... Li H.	2005	SERPINE1
22	Deep vein thrombosis. (15794972)	Kyrle P.A.... Eichinger S.	2005	SERPINC1
23	Activated protein C resistance due to factor V Leiden, elevated coagulation factor VIII and postoperative deep vein thrombosis in late breast reconstruction with a free TRAM flap: a report of two cases. (15992531)	Olsson E.... HAPijer P.	2005	F8, F5
24	No association between pulmonary embolism or deep vein thrombosis and the -455G/A beta-fibrinogen gene polymorphism. (15795538)	Camilleri R.S.... Cohen H.	2005	FGB
25	Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase. (15063833)	Klocker J.... Schwelberger H.G.	2004	ABP1
26	Beta-receptor blockade decreases elevated plasma levels of factor VIII:C in patients with deep vein thrombosis. (15304037)	Hoppener M.R.... Levi M.	2004	F8
27	Application of recombinant human activated protein C with blood product administration and deep vein thrombosis in severe sepsis (15535893)	Liu L.... Qiu H.B.	2004	F5
28	The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism. (14597977)	Wells P.S.... Jaffey J.	2003	F2, ACE, F5
29	Deep vein thrombosis after orthopedic surgery in a pa tient with type 1 von Willebrand disease and mutations in the MTHFR and beta-fi brinogen genes. (14597997)	Franchini M.... Veneri D.	2003	MTHFR
30	Clinical and functional assessment after anticoagulant therapy of acute deep vein thrombosis involving the lower limb. (12950126)	Huh S.H.... Joh J.H.	2003	SERPINC1
31	Three risk factors--high lipoprotein (a), elevated FVIII, and FV Leiden--in a pediatric BehAset's disease patient with deep vein thrombosis. (12297135)	GAPzdaA9oA9lu S.... Akar N.	2002	F8
32	Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis. (12431473)	WAYhlander K.... Eriksson H.	2002	F3
33	Markers of hemostatic system activation during treatment of deep vein thrombosis with subcutaneous unfractionated or low-molecular weight heparin. (11927130)	Peternel P.... Stegnar M.	2002	F2, SERPINC1, F3
34	CBS 844ins68, MTHFR TT677 and EPCR 4031ins23 genotypes in patients with deep-vein thrombosis. (12413583)	Grossmann R.... Walter U.	2002	CBS, MTHFR, PROCR
35	Plasma tissue factor pathway inhibitor levels as a marker for postoperative bleeding after enoxaparin use in deep vein thrombosis prophylaxis in orthopedics and general surgery. (11190908)	Hakki S.I.... Wright T.	2001	F2
36	Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis. (11302483)	Suehisa E.... Kanakura Y.	2001	SERPINC1
37	Upper extremity deep vein thrombosis in a young patient double heterozygous for factor V Leiden and prothrombin G20210A mutation. (11190909)	VayA! A.... Aznar J.	2001	F5
38	Risk factors and management of patients with upper limb deep vein thrombosis. (10631197)	Ellis M.H.... Witz M.	2000	APOH
39	Plasma tissue factor pathway inhibitor levels as a marker for postoperative bleeding after enoxaparin use in deep vein thrombosis prophylaxis in orthopedics and general surgery. (11030526)	Hakki S.I.... Wright T.	2000	F2
40	Deep vein thrombosis during enoxaparin prophylactic treatment in a young pregnant woman homozygous for factor V Leiden and heterozygous for the G127-->a mutation in the thrombomodulin gene. (11132655)	Magdelaine A.... Soubrier F.	2000	F5
41	Deep vein thrombosis outcome and the level of oral an ticoagulation therapy. (10550177)	Caprini J.A.... Cohen E.B.	1999	F3
42	Is the prevalence of the factor V Leiden mutation in patients with pulmonary embolism and deep vein thrombosis really different? (10102457)	Turkstra F.... BA1ller H.R.	1999	F5
43	Oral contraception and factor V Leiden mutation in relation to localization of deep vein thrombosis. (9692618)	Andersen B.S.... Olsen J.	1998	F5
44	Deep-vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus-like features. (9462552)	Kamphuisen P.W.... Van der Meer F.J.	1998	F5
45	Relation between the time to achieve the lower limit of the APTT therapeutic range and recurrent venous thromboembolism during heparin treatment for deep vein thrombosis. (9531224)	Hull R.D.... Valentine K.A.	1997	F3
46	Fibrinolytic parameters in patients undergoing total hip replacement: relationship with the development of asymptomatic deep vein thrombosis and diagnostic usefulness of venous occlusion. (9175322)	Trotti R.... Piovella F.	1997	PLAT
47	A novel G/A and the 4G/5G polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis. (8987164)	Grubic N.... Binder B.R.	1996	SERPINE1
48	The treatment of deep vein thrombosis with continuous intravenous low-molecular-weight dermatan sulphate (Desmin). A pilot study. (8987160)	Kretz J.G.... Cazenave J.P.	1996	F10, DES
49	Physician-guided treatment compared with a heparin protocol for deep vein thrombosis. (8179457)	Elliott C.G.... Kitterman N.	1994	F3
50	Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis. (1346817)	Prandoni P.... Ten Cate J.W.	1992	F3

Genes related to deep vein thrombosis according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	CTEPH1	Pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to	11.1	Aliases & Descriptions
2	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
3	TNXA	tenascin XA (pseudogene)	11.0	Publications
4	PROCR	protein C receptor, endothelial	11.0	Publications
5	PROS1	protein S (alpha)	11.0	Publications
6	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
7	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.0	Publications
8	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
9	F9	coagulation factor IX	11.0	Publications
10	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
11	PLAT	plasminogen activator, tissue	11.0	Publications
12	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
13	F2	coagulation factor II (thrombin)	11.0	Publications
14	F10	coagulation factor X	11.0	Publications
15	TTF2	transcription termination factor, RNA polymerase II	11.0
16	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
17	THBD	thrombomodulin	11.0	Publications
18	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
19	F8	coagulation factor VIII, procoagulant component	11.0	Publications
20	FGB	fibrinogen beta chain	11.0	Publications
21	GGCX	gamma-glutamyl carboxylase	11.0	Publications
22	NFKBIL1	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	11.0	Publications
23	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
24	CYP4V2	cytochrome P450, family 4, subfamily V, polypeptide 2	11.0	Publications
25	KLKB1	kallikrein B, plasma (Fletcher factor) 1	11.0	Publications
26	VKORC1	vitamin K epoxide reductase complex, subunit 1	11.0	Publications
27	F11	coagulation factor XI	11.0	Publications
28	F12	coagulation factor XII (Hageman factor)	11.0	Publications
29	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
30	CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	11.0	Publications
31	FGA	fibrinogen alpha chain	11.0	Publications
32	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.0	Publications
33	CBS	cystathionine-beta-synthase	11.0	Publications
34	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0	Publications
35	DES	desmin	11.0	Publications
36	PLG	plasminogen	11.0	Publications
37	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0	Publications
38	EPO	erythropoietin	11.0	Publications
39	VWF	von Willebrand factor	11.0	Publications
40	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
41	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
42	CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	11.0	Publications
43	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
44	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
45	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
46	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
47	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
48	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
49	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
50	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications

Pathways related to deep vein thrombosis according to GeneDecks:

(show all 35)

id	Pathway	Score	Top Affiliating Genes
1	Gamma-carboxylation of protein precursors38	10.4	F9, F10
2	Common Pathway38	10.4	SERPINC1, F13A1, F5
3	Cell surface interactions at the vascular wall38	10.3	SELP, F2, THBD, PROC
4	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.3	MTRR, MTHFR, MTR, CBS
5	Warfarin Pathway, Pharmacodynamics34	10.3	GGCX, VKORC1, F9, F2, F10, PROS1
6	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.2	CBS, MTR, MTHFR, MTRR
7	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	10.2	MTR, MTRR, CBS, MTHFR
8	Platelet activation, signaling and aggregation38	10.2	FGA, FGB, PPBP, PLG, VWF
9	Cell adhesion molecules (CAMs)20	10.1	SELP, HLA-DPB1
10	Graft-versus-host disease20	10.1	HLA-A, HLA-DPB1, HLA-B
11	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.9	PTGS1, F2, FGB, FGA, ITGB3, VWF
12	MSP-RON Signaling36	9.8	TNF, F12, F11, KLKB1
13	Cell adhesion_PLAU signaling41	9.8	HGF, PLAT, PLAU, SERPINE1, PLG
14	Cell adhesion PLAU signaling10	9.8	SERPINE1, PLAT, PLG, HGF, PLAU
15	Selected targets of HNF110	9.7	PROC, APOH, CRP, F13A1, F8
16	Cell adhesion ECM remodeling10	9.7	PLAT, PLAU, SERPINE1, PLG
17	Cell adhesion Plasmin signaling10	9.7	F12, PLAT, PLAU, FGB, KLKB1, FGA
18	Cell adhesion_Plasmin signaling41	9.7	PLAU, PLAT, KLKB1, PLG, F12, FGB
19	Cell adhesion_ECM remodeling41	9.6	PLG, PLAU, PLAT, SERPINE1
20	Immune response IL-1 signaling pathway10	9.6	TNF, SERPINE1, F3, NFKB1
21	Extrinsic Prothrombin Activation Pathway36	9.6	SERPINC1, FGA, FGB, F5, F3, PROS1
22	Immune response_IL-1 signaling pathway41	9.6	SERPINE1, F3, TNF, NFKB1
23	Intrinsic Prothrombin Activation Pathway36	9.3	FGB, F9, F8, F5, F2, F10
24	Staphylococcus aureus infection20	9.3	PLG, HLA-DRB1, SELP, HLA-DPB1
25	Blood Coagulation Cascade36	9.2	KLKB1, SERPINC1, F13A1, F12, F11, F10
26	Development_VEGF signaling via VEGFR2 - generic cascades41	9.1	ITGB3, NOS3, PLAU, PTGS1, NFKB1
27	Autoimmune thyroid disease20	9.1	HLA-DPB1, HLA-DRB1, HLA-B, HLA-A
28	Chagas disease (American trypanosomiasis)20	8.9	TNF, NFKB1, SERPINE1, ACE, TNFRSF1A
29	Allograft rejection20	8.8	HLA-DRB1, HLA-DPB1, HLA-B, HLA-A, TNF
30	Type I diabetes mellitus20	8.7	HLA-A, TNF, HLA-DRB1, HLA-DPB1, HLA-B
31	Antigen processing and presentation20	8.7	HLA-DRB1, HLA-A, HLA-B, TNF, HLA-DPB1
32	Influenza A20	8.5	TNFRSF1A, NFKB1, PLG, TNF, HLA-DPB1, HLA-DRB1
33	Blood Coagulation Signaling Pathways37	8.4	PROS1, THBD, KLKB1, PLG, PLAU, PLAT
34	Complement and coagulation cascades20	8.3	VWF, SERPINC1, SERPINE1, KLKB1, THBD, PROS1
35	Toxoplasmosis20	8.1	HLA-DPB1, HLA-DRB1, TNF, NFKB1, TNFRSF1A

Compounds related to deep vein thrombosis according to GeneDecks:

(show top 50)    (show all 363)

id	Compound	Score	Top Affiliating Genes
1	fondaparinux32	10.3	PLAT, TNXA, F10, F2, F3, F5
2	Drotrecogin alfa9 9	11.2	GGCX, PROCR, PROS1, THBD, F2, F5
3	ancrod32	10.2	THBD, PLAT, F10, F2, F5, FGA
4	kaolin32	10.2	F8, F9, APOH, F5, F3, F2
5	ximelagatran32 9 9	12.2	SERPINC1, GPT, F2, CYP2C9, F10
6	cyclophosphamide32 34 9 9	13.1	F8, F9, APOH
7	batroxobin32	10.1	SERPINE1, SELP, FGA, FGB, F5, PLAT
8	coumarins32	10.1	VKORC1, APOH, F9, CYP2C9, F10, F2
9	citrate32	10.0	SELP, F9, NOS3, PPBP, F10, F8
10	argatroban32 9 9	11.9	THBD, PLAT, TNXA, F10, F2, F3
11	gamma-carboxyglutamic acid32	9.9	GGCX, PROCR, PROC, PROS1, THBD, TNXA
12	bivalirudin32 9 9	11.9	THBD, PLAT, TNXA, F10, F2, F3
13	ristocetin32	9.9	F11, F2, F8, F9, SERPINC1, SELP
14	ppack32	9.9	F3, FGA, SERPINC1, SELP, VWF, F2
15	protamine32	9.9	SELP, PLAT, TNXA, F10, F2, F3
16	coumarin32 18	10.7	CYP2C9, HLA-B, F10, F2, F3, F5
17	hirudin32	9.6	PROCR, THBD, PLAU, TNXA, F11, F10
18	11-dehydrothromboxane b232	9.5	VWF, SELP, SERPINE1, FGA, THBD, PPBP
19	ticlopidine32 9 9	11.5	PLAT, PPBP, CYP2C9, PTGS1, F3, APOH
20	tranexamic acid32 9 9	11.5	EPO, PLG, PLAU, PLAT, F8, F9
21	clopidogrel32 34 9 18 9	13.5	ACE, PPBP, CYP2C9, PTGS1, TNXA, F10
22	tirofiban32 9 9	11.3	ITGB3, SERPINC1, SELP, VWF, PLAT, CRP
23	aspartate32	9.2	HGF, THBD, PLAU, SULT1A3, F10, F2
24	pge132	9.2	THBD, PLAU, PLAT, PPBP, F5, GPT
25	endotoxin32	9.1	PROCR, THBD, ABP1, KLKB1, FGA, CRP
26	aprotinin32 9 9	11.0	THBD, SELP, VWF, SERPINC1, FGA, F9
27	dermatan sulfate32	8.8	THBD, PLAU, PLAT, TNXA, F11, F10
28	desmopressin32 42 9 9	11.8	SELP, VWF, SERPINC1, PLAT, PPBP, PTGS1
29	cysteine32	8.6	VKORC1, SELP, TTF2, KLKB1, PLAU, PLAT
30	atorvastatin32 34 9 18 9	12.1	TNF, F5, GPT, SELP, VWF, CYP2C9
31	homocysteine32 18	9.0	THBD, MTR, MTHFR, MTRR, SERPINE1, SERPINC1
32	warfarin32 34 9 18 9	12.0	GGCX, PROC, THBD, TTF2, ACE, PLAT
33	kininogen32	7.9	F5, F9, APOH, SERPINE1, SERPINC1, SELP
34	glutamate32	7.8	GGCX, HGF, PLAU, PLAT, TNFRSF1A, ESR2
35	simvastatin32 34 42 9 18 9	12.5	THBD, NOS3, PLAT, CRP, CYP2C9, TNFRSF1A
36	heparin32 9 18 9	10.5	HGF, PROC, PROS1, DES, TTF2, F3
37	cyclosporin a32 42	8.3	EPO, HGF, THBD, TTF2, VWF, SELP
38	estrogen32	7.3	F2, F8, F9, APOH, ITGB3, MTR
39	cholesterol32 9 18 9	9.8	HLA-B, CBS, F5, F8, F9, GPT
40	lactate32	6.6	EPO, F5, F8, GPT, APOH, FGA
41	aspirin32 34 18	8.6	ACE, F5, F8, APOH, FGA, ITGB3
42	methotrexate32 34 42 9 9	10.5	EPO, HGF, NOS3, CRP, TNFRSF1A, TNF
43	alanine32	6.3	HGF, THBD, TTF2, F8, F9, GPT
44	fibrinogen32	6.3	F12, SERPINC1, SELP, SERPINE1, ITGB3, FGA
45	creatinine32	6.2	TNFRSF1A, VWF, SELP, SERPINC1, HLA-B, F3
46	prostacyclin32	6.1	HGF, ESR2, F3, F5, F8, APOH
47	nitric oxide32 9 18 9	9.0	PROCR, DES, THBD, TTF2, ACE, NFKB1
48	arginine32	5.9	HLA-DRB1, VWF, SELP, SERPINC1, APOH, HLA-B
49	vegf32	5.2	NOS3, F5, F8, APOH, ITGB3, SERPINE1
50	serine32	5.2	HGF, PROCR, PROC, PROS1, TNF, HLA-B

Cellular components related to deep vein thrombosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule	GO:031091	10.1	VWF, FGA, FGB
2	Golgi lumen	GO:005796	10.0	F2, F9, F10, PROS1, PROC
3	platelet alpha granule lumen	GO:031093	9.1	VWF, SERPINE1, FGA, FGB, F8, F5
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.9	HLA-B, HLA-A, HLA-DPB1, HLA-DRB1
5	ER to Golgi transport vesicle membrane	GO:012507	8.6	HLA-DRB1, HLA-B, HLA-DPB1, HLA-A
6	external side of plasma membrane	GO:009897	7.9	VWF, FGA, ACE, TNF, HLA-DRB1, FGB
7	extracellular region	GO:005576	6.7	VWF, F10, F12, F11, F2, F5
8	extracellular space	GO:005615	6.0	FGA, PLG, PLAU, PLAT, CRP, PPBP
9	plasma membrane	GO:005886	3.9	PLAU, PTGS1, TNFRSF1A, TNF, PLG, NOS3

Biological processes related to deep vein thrombosis according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation, extrinsic pathway	GO:007598	10.5	F3, F9, F10
2	negative regulation of blood coagulation	GO:030195	10.4	SERPINE1, THBD, PROC, APOH
3	positive regulation of blood coagulation	GO:030194	10.4	F12, F2, APOH, SERPINE1
4	plasminogen activation	GO:031639	10.4	APOH, F11, PLAT, KLKB1
5	negative regulation of fibrinolysis	GO:051918	10.3	F2, SERPINE1, THBD, PLG, APOH
6	positive regulation of fibrinolysis	GO:051919	10.2	F11, F12, PLG, KLKB1
7	Factor XII activation	GO:002542	10.2	F12, KLKB1
8	homocysteine metabolic process	GO:050667	10.2	MTR, CBS, MTHFR
9	peptidyl-glutamic acid carboxylation	GO:017187	10.2	F9, F2, F10, PROS1, PROC, GGCX
10	post-translational protein modification	GO:043687	10.1	F9, GGCX, F2, F10, PROS1, PROC
11	negative regulation of platelet activation	GO:010544	10.0	NOS3, F2, THBD
12	leukocyte migration	GO:050900	9.9	PROC, PROS1, THBD, F2, ITGB3, SELP
13	response to hyperoxia	GO:055093	9.9	EPO, NOS3, SERPINE1
14	blood coagulation, intrinsic pathway	GO:007597	9.8	KLKB1, F12, F11, F10, F2, F8
15	fibrinolysis	GO:042730	9.7	PROS1, F12, SERPINE1, KLKB1, PLG, PLAU
16	response to lipopolysaccharide	GO:032496	9.4	TNFRSF1A, SELP, F3, THBD, EPO
17	negative regulation of lipid storage	GO:010888	9.3	TNF, CRP, ITGB3
18	detection of bacterium	GO:016045	9.1	HLA-A, HLA-DRB1, HLA-B
19	platelet degranulation	GO:002576	8.8	HGF, PROS1, PLG, PPBP, F13A1, F5
20	platelet activation	GO:030168	8.7	VWF, SELP, F5, FGB, F2, F13A1
21	anti-apoptosis	GO:006916	8.6	F3, EPO, NFKB1, NOS3, TNF, HGF
22	proteolysis	GO:006508	8.5	PLG, PLAT, F11, F10, F2, HGF
23	blood coagulation	GO:007596	6.9	PLAU, PLAT, PPBP, F13A1, F12, F11

Molecular functions related to deep vein thrombosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	9.6	APOH, FGB, FGA, SELP, EPO
2	heparin binding	GO:008201	9.5	F11, ABP1, SELP, SERPINC1, APOH
3	protease binding	GO:002020	9.5	SERPINE1, F3, TNF, TNFRSF1A, SERPINC1
4	heme binding	GO:020037	9.4	CBS, NOS3, CYP2C9, CYP4V2, PTGS1
5	serine-type endopeptidase activity	GO:004252	9.0	F11, HGF, PROC, KLKB1, PLG, PLAU
6	protein binding	GO:005515	3.4	DES, NOS3, PLG, PLAU, PLAT, CRP