Aliases & Classifications for Deficiency Anemia

MalaCards integrated aliases for Deficiency Anemia:

Name: Deficiency Anemia 38 12 14
Anemia 38 12 72 28 51 40 41 14 69 59
Deficiency Anemias 12 69
Unspecified Deficiency Anemia 12
Deficiency Anemias Nos 12
Anaemia 12

Classifications:



Summaries for Deficiency Anemia

MedlinePlus : 40 If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body. Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. Conditions that may lead to anemia include Heavy periods Pregnancy Ulcers Colon polyps or colon cancer Inherited disorders A diet that does not have enough iron, folic acid or vitamin B12 Blood disorders such as sickle cell anemia and thalassemia, or cancer Aplastic anemia, a condition that can be inherited or acquired G6PD deficiency, a metabolic disorder Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache. Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Deficiency Anemia, also known as anemia, is related to iron-refractory iron deficiency anemia and anemia, sideroblastic, 1, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Deficiency Anemia is TMPRSS6 (Transmembrane Protease, Serine 6), and among its related pathways/superpathways are Insulin receptor recycling and Selenium Micronutrient Network. The drugs Iron and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

PubMed Health : 59
About anemia: Anemia (uh-NEE-me-uh) is a condition in which your blood has a lower than normal number of red blood cells.Anemia also can occur if your red blood cells don't contain enough hemoglobin (HEE-muh-glow-bin). Hemoglobin is an iron-rich protein that gives blood its red color. This protein helps red blood cells carry oxygen from the lungs to the rest of the body.If you have anemia, your body doesn't get enough oxygen-rich blood. As a result, you may feel tired or weak. You also may have other symptoms, such as shortness of breath, dizziness, or headaches.Severe or long-lasting anemia can damage your heart, brain, and other organs in your body. Very severe anemia may even cause death.

Wikipedia : 72 Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a... more...

Related Diseases for Deficiency Anemia

Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.6 EPO HFE2 TMPRSS6
2 anemia, sideroblastic, 1 34.4 HAMP HBB TFRC
3 aplastic anemia 34.1 CSF3 EPO HFE IL6 THPO
4 folic acid deficiency anemia 33.8 CRP EPO TF TFRC THPO
5 iron deficiency anemia 32.9 CRP EPO HAMP HFE HFE2 IL6
6 microcytic anemia 32.4 EPO G6PD SLC11A2 TF TFRC TMPRSS6
7 iron metabolism disease 32.1 CP EPO HFE HFE2 SLC11A2 SLC40A1
8 thalassemia 31.0 EPO HBB HFE TF TFRC
9 thrombocytosis 30.9 CRP EPO IL6 THPO
10 chronic kidney failure 30.4 ALB CRP EPO IL6 TF
11 pancytopenia 30.2 CSF3 EPO THPO
12 hyperferritinemia with or without cataract 30.2 HFE TF
13 hemosiderosis 30.1 CP EPO HAMP HFE SLC11A2 SLC40A1
14 sickle cell disease 30.1 EPO G6PD HBB HBG2
15 hemoglobinopathy 30.1 EPO HAMP HBB HFE TF
16 dysentery 30.0 ALB CRP TF
17 beta-thalassemia 29.9 EPO G6PD HAMP HBB HBG2 HFE
18 glucosephosphate dehydrogenase deficiency 29.9 G6PD HBB HBG2
19 congenital hemolytic anemia 29.9 EPO G6PD HBB TF
20 intestinal disease 29.9 ALB CRP IL6
21 protein-energy malnutrition 29.9 ALB CP IL6 TF
22 sickle cell anemia 29.8 EPO G6PD HBB HBG2
23 anemia of prematurity 29.8 CSF3 EPO EPOR HAMP
24 diabetes mellitus 29.8 ALB CP CRP HFE IL6
25 hypochromic microcytic anemia 29.8 CP HBB SLC11A2 TF TMPRSS6
26 restless legs syndrome 29.8 EPO SLC11A2 TFRC
27 polycythemia 29.7 EPO EPOR HBB TFRC THPO
28 malaria 29.0 ALB CRP CSF3 EPO G6PD HAMP
29 hemochromatosis, type 1 29.0 CP HAMP HBB HFE HFE2 SLC11A2
30 fanconi anemia, complementation group a 12.4
31 diamond-blackfan anemia 12.3
32 protein-deficiency anemia 12.0
33 pyridoxine deficiency anemia 12.0
34 hereditary orotic aciduria without megaloblastic anaemia 11.9
35 adenosine triphosphatase deficiency, anemia due to 11.8
36 anemia, autoimmune hemolytic 11.4
37 myopathy, lactic acidosis, and sideroblastic anemia 1 11.4
38 hereditary elliptocytosis 11.3
39 triosephosphate isomerase deficiency 11.3
40 pyruvate kinase deficiency of red cells 11.1
41 hernia, hiatus 11.0
42 gastric antral vascular ectasia 11.0
43 autoimmune atrophic gastritis 11.0
44 uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to 10.9
45 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.9
46 iron overload in africa 10.7 HFE TF
47 anemia, congenital dyserythropoietic, type iii 10.7
48 pernicious anemia 10.7
49 ancylostomiasis 10.7
50 vibrio vulnificus infection 10.7 EPO IL6

Comorbidity relations with Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 340)


3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Acute Kidney Failure
Acute Leukemia Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Acute Vascular Insufficiency of Intestine
Adjustment Disorder Adrenal Gland Disease
Agammaglobulinemia, X-Linked Alcohol Abuse
Alcoholic Gastritis Alcoholic Hepatitis
Alcoholic Liver Cirrhosis Alcoholic Neuropathy
Alzheimer Disease Amyloidosis
Anemia, Autoimmune Hemolytic Anus Cancer
Anxiety Aortic Aneurysm
Aortic Atherosclerosis Aortic Valve Disease 1
Asbestosis Ascending Colon Cancer
Aspergillosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autonomic Nervous System Disease Bacteremia 2
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Hypertensive Renal Disease Biliary Tract Neoplasm
Bladder Cancer Bleeding Disorder, Platelet-Type, 11
Blepharitis Bronchiectasis
Bronchitis Bronchopneumonia
Bullous Pemphigoid Candidiasis
Cardiac Arrest Cardiogenic Shock

Graphical network of the top 20 diseases related to Deficiency Anemia:



Diseases related to Deficiency Anemia

Symptoms & Phenotypes for Deficiency Anemia

UMLS symptoms related to Deficiency Anemia:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Deficiency Anemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 CP HFE2 IL6 CSF3 EPO SLC11A2
2 homeostasis/metabolism MP:0005376 10.16 CP HFE2 CRP IL6 EPO SLC11A2
3 cardiovascular system MP:0005385 10.11 CP HFE2 CRP IL6 EPO SLC11A2
4 immune system MP:0005387 10 HFE CP HFE2 CRP CSF3 IL6
5 integument MP:0010771 9.56 HFE2 CSF3 IL6 EPO SLC11A2 SLC40A1
6 liver/biliary system MP:0005370 9.4 CP HFE2 IL6 EPO SLC11A2 EPOR

Drugs & Therapeutics for Deficiency Anemia

PubMedHealth treatment related to Deficiency Anemia: 59

Treatment for anemia depends on the type, cause, and severity of the condition. Treatments may include dietary changes or supplements, medicines, procedures, or surgery to treat blood loss.

Drugs for Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 181)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
2
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051 23994
3
Halofantrine Approved Phase 4 69756-53-2 37393
4
Copper Approved, Investigational Phase 4 7440-50-8 27099
5
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
6
Iodine Approved, Investigational Phase 4 7553-56-2 807
7
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Metronidazole Approved Phase 4 443-48-1 4173
10
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
11
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 68-26-8, 11103-57-4 445354
12
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1 50-81-7 54670067 5785
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
15
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
16
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
17
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
18
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
19
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
20
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
21
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
22
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
23 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 1
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
25
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-02-9 14985
26
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 77-92-9 311
27
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 56-40-6 750
28 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1
29 Ferric oxide, saccharated Phase 4,Phase 3,Phase 2,Phase 1
30 Hematinics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Teferrol Phase 4
34 Retinol palmitate Phase 4,Phase 3,Phase 2
35 Vitamins Phase 4,Phase 3,Phase 1,Early Phase 1
36 Ferrosoferric Oxide Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Parenteral Nutrition Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Vitamin B Complex Phase 4,Phase 3
40 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
41 Blood Substitutes Phase 4,Phase 3,Phase 2,Phase 1
42 Dextrans Phase 4,Phase 3,Phase 2,Phase 1
43 Iron-Dextran Complex Phase 4,Phase 3,Phase 2,Phase 1
44 Plasma Substitutes Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
46 Lactoferrin Phase 4,Phase 1,Phase 2
47 Ferrous fumarate Phase 4,Phase 3,Phase 1,Early Phase 1
48 ferric gluconate Phase 4,Phase 2,Phase 3
49 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1 113427-24-0
50 cadexomer iodine Phase 4

Interventional clinical trials:

(show top 50) (show all 285)

# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
3 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
4 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
5 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
6 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
7 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
8 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
9 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
10 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
11 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
12 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
13 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
14 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
15 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
16 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
17 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
18 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
19 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
20 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
21 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
22 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4 Captafer®;Iron Sulfate
23 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
24 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Recruiting NCT03236246 Phase 4 KRX-0502
25 Iron Deficiency Anemia, Iron Supplementation and Genomic Stability in Infants Recruiting NCT03359447 Phase 4 Weekly Ferrous Sulfate;Daily Ferrous Sulfate
26 Eradication of H-pylori in Pregnancy and Its Effect on Iron Replacement Therapy? Recruiting NCT03347513 Phase 4 triple attack therapy;Ferrous(II)-glycine-sulphate complex 567.7 mg capsules
27 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Recruiting NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
28 FLIPS: Ferfer Liposomal Iron Performance Study Recruiting NCT03112187 Phase 4 Iron Supplement
29 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
30 to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants Recruiting NCT03171324 Phase 4 Iron Supplement
31 Iron Treatment for Young Children With Non-anemic Iron Deficiency Recruiting NCT01481766 Phase 4
32 Intravenous Iron Isomaltoside 1000 (Monofer®) Compared With Oral Iron in the Treatment of Postgastrectomy Anemia: An Open-label Randomized Controlled Trial Recruiting NCT03229954 Phase 4 iron isomaltoside (Monofer) intravenous infusion;Ferrous sulfate(Feroba-YOU) per oral
33 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Recruiting NCT01953107 Phase 4
34 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
35 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
36 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4 ferumoxytol;gadofosveset
37 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
38 Preoperative Intravenous Iron Infusion to Reduce Post-surgical Complications: a Pilot Randomised Control Trial Recruiting NCT03295851 Phase 4 Ferric carboxymaltose;Ferrous Fumarate
39 Treatment Response of Injectafer vs Oral Iron to Baseline Hepcidin Levels in Patients With Iron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass Active, not recruiting NCT02086968 Phase 4 Injectafer;Ferrous Sulfate tablets
40 Trial to Evaluate the Utility of Serum Hepcidin Levels to Predict Response to Oral or IV Iron and to Compare Safety, Effect on Quality of Life, and Resource Utilization of Injectafer vs Intravenous Standard of Care for the Treatment of IDA in an Infusion Active, not recruiting NCT01950247 Phase 4 Injectafer;SOC
41 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Not yet recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
42 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency Anaemia in Pregnancy. Not yet recruiting NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
43 Trial Comparing the Safety of Two Different Intravenous Iron Formulations Suspended NCT00593619 Phase 4 Iron dextran;Iron sucrose
44 Ferric Carboxymaltose for Treatment of Anaemia of Cancer in Subjects With Multiple Myeloma Receiving Chemotherapy Terminated NCT01100879 Phase 4 Ferric carboxymaltose
45 Intravenous Ferric Carboxymaltose (Ferinject®) With or Without Erythropoietin in Patients Undergoing Orthopaedic Surgery Terminated NCT00706667 Phase 4 Ferinject ®
46 A Clinical Trial of Oral Versus IV Iron in Patients With Chronic Kidney Disease Terminated NCT00830037 Phase 4 IV Iron;Ferrous Sulfate
47 Safety Assessment of Iron Sucrose (Venofer) in Patients With Chronic Kidney Disease Who Cannot Tolerate Ferumoxytol (Feraheme) or Iron Dextran (INFed or Dexferrum) Withdrawn NCT01151592 Phase 4 Iron Sucrose
48 Helicobacter Pylori and Iron Deficiency: Prevalence of Association and Effect of Therapy Withdrawn NCT00475527 Phase 4 omeprazole,clarithromycin,amoxicillin (or metronidazole)
49 Effect of CFR and Iron Supplementation on Iron Status and Gut Microbiota of 1-2 Years Old Myanmar Children Unknown status NCT01758159 Phase 3
50 A Randomized Trial of Oral Iron Therapy in Fibromyalgia Unknown status NCT01820052 Phase 3 Oral Iron;Oral Placebo

Search NIH Clinical Center for Deficiency Anemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: anemia

Genetic Tests for Deficiency Anemia

Genetic tests related to Deficiency Anemia:

# Genetic test Affiliating Genes
1 Anemia 28

Anatomical Context for Deficiency Anemia

MalaCards organs/tissues related to Deficiency Anemia:

38
Kidney, Heart, Colon, Lung, Testes, Brain, Bone

Publications for Deficiency Anemia

Articles related to Deficiency Anemia:

(show top 50) (show all 820)
# Title Authors Year
1
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
2
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
3
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
4
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
5
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
6
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
7
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
8
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
9
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
10
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
11
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
12
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
13
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
14
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
15
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
16
Efficacy and safety of IV ferumoxytol for iron deficiency anemia in patients with cancer. ( 29263710 )
2017
17
Electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure. ( 29268978 )
2017
18
Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. ( 29282766 )
2017
19
Comment: Intravenous Ferumoxytol in Pediatric Patients With Iron Deficiency Anemia. ( 28925297 )
2017
20
Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence. ( 28854239 )
2017
21
Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. ( 28073037 )
2017
22
Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort. ( 28833205 )
2017
23
Sodium chloride pica causing recurrent nephrolithiasis in a patient with iron deficiency anemia: a case report. ( 29149910 )
2017
24
Idiopathic Pulmonary Hemosiderosis Mimicking Iron Deficiency Anemia: A Delayed Diagnosis? ( 28670434 )
2017
25
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. ( 28052413 )
2017
26
VON WILLEBRAND FACTOR IMMUNOHISTOCHEMICAL STAINING QUANTITATIVE OPTICAL DENSITY PARAMETERS IN THE ENDOTHELIUM AND FIBRINOID OF THE PLACENTA DURING SECUNDINES INFLAMMATION AND CONCOMITANT IRON DEFICIENCY ANEMIA IN GRAVIDAS. ( 29328041 )
2017
27
Author's reply: Directly observed iron supplementation for control of iron deficiency anemia. ( 28928309 )
2017
28
The Relationship Between Iron Deficiency Anemia and Sensorineural Hearing Loss in the Pediatric and Adolescent Population. ( 28492865 )
2017
29
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
2017
30
Prevalence of Iron Deficiency and Iron Deficiency Anemia in the Northern and Southern Provinces of Rwanda. ( 28826251 )
2017
31
Challenges in the diagnosis of iron deficiency anemia in aged people. ( 28830594 )
2017
32
Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis. ( 28957722 )
2017
33
Iron deficiency anemia and Plummer-Vinson syndrome: current insights. ( 29089792 )
2017
34
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
2017
35
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
2017
36
Assessment of the Matos & Carvalho index for distinguishing thalassemia from iron deficiency anemia. ( 28830614 )
2017
37
A budget impact analysis of parenteral iron treatments for iron deficiency anemia in the UK: reduced resource utilization with iron isomaltoside 1000. ( 28848355 )
2017
38
Effects of Ferric Citrate in Patients with Nondialysis-Dependent CKD and Iron Deficiency Anemia. ( 28082519 )
2017
39
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. ( 28934514 )
2017
40
Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. ( 28901214 )
2017
41
Comparison of Different Iron Preparations in the Prophylaxis of Iron-deficiency Anemia. ( 28872486 )
2017
42
QUANTITATIVE ASSESSMENT OF THE RESULTS OF VIMENTIN IMMUNOHISTOCHEMICAL EXAMINATION IN FIBROBLASTS AND ENDOTHELIOCYTES OF THE PLACENTAL VILLI IN THE ASPECT OF PRETERM MATURATION OF THE CHORIONIC TREE AND IRON DEFICIENCY ANEMIA OF GRAVIDAS. ( 29328038 )
2017
43
Delusional parasitosis secondary to severe iron deficiency anemia. ( 28879221 )
2017
44
Reply: Intravenous Ferumoxytol in Pediatric Patients With Iron-Deficiency Anemia. ( 28831808 )
2017
45
Ability of serum ferritin to diagnose iron deficiency anemia in an elderly cohort. ( 28830601 )
2017
46
Curative resectability of gastrointestinal cancer identified from iron deficiency anemia. ( 28943943 )
2017
47
Cerebral Venous Thrombosis in a Patient with Iron Deficiency Anemia and Thrombocytopenia: A Case Report. ( 29362628 )
2017
48
Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children. ( 28667789 )
2017
49
Primary care physicians are under-testing for celiac disease in patients with iron deficiency anemia: Results of a national survey. ( 28931034 )
2017
50
Iron Refractory Iron Deficiency Anemia in Dizygotic Twins Due to a Novel TMPRSS6 Gene Mutation in Addition to Polymorphisms Associated With High Susceptibility to Develop Ferropenic Anemia. ( 28491880 )
2017

Variations for Deficiency Anemia

ClinVar genetic disease variations for Deficiency Anemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB; HBD NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh38 Chromosome 11, 5226570: 5233984

Expression for Deficiency Anemia

Search GEO for disease gene expression data for Deficiency Anemia.

Pathways for Deficiency Anemia

Pathways related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 CP SLC11A2 SLC40A1 TF TFRC
2
Show member pathways
12.17 ALB CRP HBB IL6
3
Show member pathways
12.15 CSF3 EPO EPOR IL6 THPO
4 11.8 CSF3 EPO IL6 THPO
5
Show member pathways
11.71 CP SLC11A2 SLC40A1
6 11.71 EPO IL6 TF TFRC
7 11.62 CSF3 EPO EPOR IL6 TFRC THPO
8 11.44 CP EPO TF TFRC
9 11.41 SLC11A2 SLC40A1 TF
10 11.38 CSF3 HBB IL6
11 11.35 EPO IL6 TF
12 11.33 CSF3 EPO IL6
13 11.26 CP SLC11A2 SLC40A1 TF TFRC
14 10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC
15 10.1 HAMP HFE HFE2 TMPRSS6

GO Terms for Deficiency Anemia

Cellular components related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB CP CRP CSF3 EPO HAMP
2 endoplasmic reticulum lumen GO:0005788 9.76 ALB CP IL6 TF
3 early endosome GO:0005769 9.73 HFE SLC11A2 TF TFRC
4 recycling endosome GO:0055037 9.67 HFE SLC11A2 TF TFRC
5 blood microparticle GO:0072562 9.63 ALB CP HBB HBG2 TF TFRC
6 basal part of cell GO:0045178 9.5 HFE SLC11A2 TF
7 hemoglobin complex GO:0005833 9.4 HBB HBG2
8 HFE-transferrin receptor complex GO:1990712 9.02 HFE HFE2 TF TFR2 TFRC
9 extracellular region GO:0005576 10.03 ALB CP CRP CSF3 EPO EPOR

Biological processes related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.96 CSF3 EPO HAMP IL6 THPO
2 cellular protein metabolic process GO:0044267 9.87 ALB CP IL6 TF
3 receptor-mediated endocytosis GO:0006898 9.83 ALB HBB TFR2 TFRC
4 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
5 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
6 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
7 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
8 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
9 oxygen transport GO:0015671 9.59 HBB HBG2
10 copper ion transport GO:0006825 9.58 CP SLC11A2
11 erythrocyte maturation GO:0043249 9.58 EPO G6PD
12 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
13 negative regulation of lipid storage GO:0010888 9.55 CRP IL6
14 positive regulation of peptide hormone secretion GO:0090277 9.54 HFE TFR2
15 iron ion transmembrane transport GO:0034755 9.51 SLC11A2 SLC40A1
16 iron ion homeostasis GO:0055072 9.5 HFE HFE2 SLC11A2 SLC40A1 TF TFR2
17 erythropoietin-mediated signaling pathway GO:0038162 9.49 EPO EPOR
18 response to iron ion starvation GO:1990641 9.48 HAMP HFE
19 ferrous iron import across plasma membrane GO:0098707 9.46 TF TFR2
20 cellular iron ion homeostasis GO:0006879 9.32 CP HAMP HFE HFE2 SLC11A2 SLC40A1

Molecular functions related to Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 CSF3 EPO IL6 THPO
2 oxygen binding GO:0019825 9.5 ALB HBB HBG2
3 oxygen carrier activity GO:0005344 9.46 HBB HBG2
4 co-receptor binding GO:0039706 9.43 HFE TFR2
5 iron ion transmembrane transporter activity GO:0005381 9.37 SLC11A2 SLC40A1
6 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
7 transferrin transmembrane transporter activity GO:0033570 9.16 TFR2 TFRC
8 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
9 transferrin receptor binding GO:1990459 8.8 HFE HFE2 TF

Sources for Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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