MCID: DFC004
MIFTS: 65

Deficiency Anemia malady

Summaries for Deficiency Anemia

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 If you have anemia, your blood does not carry enough oxygen to the rest of your body. the most common cause of anemia is not having enough iron. your body needs iron to make hemoglobin. hemoglobin is an iron-rich protein that gives the red color to blood. it carries oxygen from the lungs to the rest of the body. anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. conditions that may lead to anemia include heavy periods pregnancy ulcers colon polyps or colon cancer inherited disorders a diet that does not have enough iron, folic acid or vitamin b12 blood disorders such as sickle cell anemia and thalassemia, or cancer aplastic anemia, a condition that can be inherited or acquired g6pd deficiency, a metabolic disorder anemia can make you feel tired, cold, dizzy, and irritable. you may be short of breath or have a headache. your doctor will diagnose anemia with a physical exam and blood tests. treatment depends on the kind of anemia you have. nih: national heart, lung, and blood institute

MalaCards: Deficiency Anemia, also known as anemia, is related to iron deficiency anemia and aplastic anemia. An important gene associated with Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are HIF-1 signaling pathway and Hematopoietic cell lineage. The drugs nandrolone and oxymetholone and the compounds fenton and deferiprone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are integument and cardiovascular system.

Disease Ontology:8 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

Wikipedia:64 Nutritional anemia refers to types of anemia that can be directly attributed to nutritional disorders. more...

Aliases & Classifications for Deficiency Anemia

Sources:
33MalaCards, 8Disease Ontology, 64Wikipedia, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

deficiency anemia 33 8
anemia 33 8 64 10 45 34 61
deficiency anemias 8 61
unspecified deficiency anemia 8
deficiency anemias nos 8


Related Diseases for Deficiency Anemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1058)
idRelated DiseaseScoreTop Affiliating Genes
1iron deficiency anemia31.9TMPRSS6, ACO1, SLC40A1, SLC11A2, THPO, HBG2
2aplastic anemia31.7TFRC, EPO, THPO
3iron-refractory iron deficiency anemia31.0TMPRSS6
4acute leukemia30.9THPO, EPO, HFE, TFRC
5thalassemia30.9HAMP, SLC11A2, HBG2, EPO, HFE, TFRC
6hepatitis c30.8TF, TFR2, HFE, LTF, THPO, SLC11A2
7refractory anemia30.8TFRC, EPO, THPO
8myelodysplastic syndromes30.8THPO, EPO, HFE, TFRC, TF
9hemoglobinuria30.7G6PD
10alpha thalassemia30.6HFE, G6PD
11beta thalassemia30.6HFE, TFRC, TF
12folic acid deficiency anemia30.6EPO, TFRC
13hereditary spherocytosis30.5G6PD, TFRC, HFE
14celiac disease30.5TFRC, HFE
15hemosiderosis30.4EPO, HFE, TF
16pyruvate kinase deficiency30.4G6PD
17diamond-blackfan anemia 130.4EPO, THPO
18tuberculosis30.2SLC11A2
19ulcerative colitis30.2LTF
20hypersplenism30.2THPO
21hepatitis b30.2LTF, HFE, TFRC
22viral hepatitis30.2HFE, G6PD
23asthma30.2HBG2, PON1
24arthritis30.2LTF, HFE, TFR2
25sickle cell disease30.2HBG2, EPO, TFRC, TF, G6PD
26hemochromatosis30.1SLC40A1, SLC11A2, HFE2, HFE, TFRC, TFR2
27wilson disease30.1G6PD, TF, HFE
28nutrition disease30.1TMPRSS6, TFRC, HAMP
29siderosis30.1TF, TFRC, HFE, SLC40A1
30hyperhomocysteinemia30.1PON1
31thromboembolism30.0G6PD
32polycythemia vera30.0THPO, EPO, G6PD
33restless legs syndrome30.0TFRC, TF
34hypochromic microcytic anemia30.0SLC11A2, TF
35diabetic nephropathy30.0SLC11A2, EPO, PON1, HFE, TFRC, TF
36erythropoietic protoporphyria30.0FECH
37porphyria cutanea tarda30.0FECH, TF, TFRC, HFE
38colorectal cancer30.0HEPH, TFRC, LTF
39uremia30.0TF, PON1, EPO
40cystic fibrosis29.8PON1, LTF
41adenocarcinoma29.8FECH
42alcohol abuse29.8HFE, TF
43pouchitis29.8LTF
44hyperferritinemia cataract syndrome29.8TF, HFE
45acute erythroid leukemia29.8FECH, TF, TFRC, EPO, THPO, ACO1
46alzheimer's disease29.8SLC11A2, PON1, HFE, IREB2
47atransferrinemia29.7TFR2, TF, HEPH
48myeloproliferative disorder29.7G6PD, EPO, THPO
49vascular disease29.5TF
50acute myocardial infarction29.4PON1, TFRC

Graphical network of the top 20 diseases related to Deficiency Anemia:



Diseases related to deficiency anemia

Clinical Features for Deficiency Anemia

Drugs & Therapeutics for Deficiency Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Deficiency Anemia

Drug clinical trials:

Search ClinicalTrials for Deficiency Anemia

Search NIH Clinical Center for Deficiency Anemia

Search CenterWatch for Deficiency Anemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Deficiency Anemia

Anatomical Context for Deficiency Anemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Deficiency Anemia:

33
Bone marrow, Whole blood, Spleen, Brain, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Breast, Skin, Placenta, Myeloid, T cells, B lymphoblasts, B cells, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Deficiency Anemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Deficiency Anemia

Sources:
51PubMed
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Articles related to Deficiency Anemia:

(show top 50)    (show all 948)
idTitleAuthorsYear
1
Goat milk consumption modulates liver divalent metal transporter 1 (DMT1) expression and serum hepcidin during Fe repletion in Fe-deficiency anemia. (24239078)
2014
2
Positive relationship between a polymorphism in Helicobacter pylori neutrophil-activating protein a gene and iron-deficiency anemia. (23067298)
2013
3
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. (24039403)
2013
4
Heart failure and iron deficiency anemia in Italy: results from CARMES-1 registry. (23668746)
2013
5
What do we know about the long-term cognitive effects of iron-deficiency anemia in infancy? (23464758)
2013
6
Socioeconomic Determinants of Iron-Deficiency Anemia Among Children Aged 6 to 59 Months in India. (23858515)
2013
7
Diagnostic yield of small-bowel capsule endoscopy in patients with iron deficiency anemia: does it affect management? (24120341)
2013
8
The transferrin/log(ferritin) ratio: a new tool for the diagnosis of iron deficiency anemia. (22868798)
2012
9
Iron deficiency anemia in children presenting with lymphoreticular malignancies and the effect of induction therapy. (22376018)
2012
10
Intravenous iron alone is equally effective with the combination of iron and erythropoietin for the treatment of iron-deficiency anemia in advanced heart failure. (23103041)
2012
11
Diagnostic yield of capsule endoscopy in the setting of iron deficiency anemia without evidence of gastrointestinal bleeding. (23061059)
2012
12
Mild maternal iron deficiency anemia during pregnancy and lactation in guinea pigs causes abnormal auditory function in the offspring. (21613451)
2011
13
FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. (21699794)
2011
14
Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). (20923825)
2010
15
Iron deficiency anemia and cognitive function in infancy. (20660551)
2010
16
Worms in the bowel: a cause of iron-deficiency anemia. (19278907)
2010
17
Upper and lower gastrointestinal causes of iron deficiency anemia in elderly compared with adult outpatients. (21139539)
2010
18
Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia. (19818657)
2010
19
Efficacy and safety of ferric carboxymaltose in correcting iron-deficiency anemia: a review of randomized controlled trials across different indications. (20648930)
2010
20
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases. (19137299)
2009
21
Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients? (20436728)
2009
22
Association of elevated homocysteine level and vitamin B12 deficiency with anemia in older adults. (19433703)
2009
23
Red cell distribution width (RDW) in the diagnosis of iron deficiency with microcytic hypochromic anemia. (19205647)
2009
24
Rapid recurrence of IBD-associated anemia and iron deficiency after intravenous iron sucrose and erythropoietin treatment. (19491860)
2009
25
Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. (19141696)
2009
26
Coexistence of symptomatic iron-deficiency anemia and duodenal nodular lymphoid hyperplasia due to giardiasis: case report. (19206009)
2009
27
Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia. (18796253)
2008
28
Early-life iron deficiency anemia alters neurotrophic factor expression and hippocampal neuron differentiation in male rats. (19022978)
2008
29
Prevalence of celiac disease, Helicobacter pylori and gastroesophageal reflux in patients with refractory iron deficiency anemia. (17908698)
2008
30
Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children. (18775429)
2008
31
Supplemental food may not prevent iron-deficiency anemia in infants. (18810337)
2008
32
Iron(III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis. (17691593)
2007
33
Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis. (17879411)
2007
34
Predictors of endoscopic and laboratory evaluation of iron deficiency anemia in hospitalized patients. (17943040)
2007
35
Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines. (17321670)
2007
36
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria. (15916292)
2005
37
Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa. (12859729)
2003
38
Glucose-6-phosphate dehydrogenase deficiency and hereditary hemolytic anemia]. (10645652)
1999
39
Profile of bone marrow iron stores in childhood iron deficiency anemia. (10770093)
1999
40
Nutritional vitamin B12 deficiency and folate deficiency in an adolescent patient presenting with anemia, weight loss, and poor school performance. (8842864)
1996
41
Anemia in Crohn's disease. Importance of inadequate erythropoietin production and iron deficiency. (8082499)
1994
42
Plasma erythropoietic activity in healthy children and in children with iron-deficiency anemia]. (8054570)
1993
43
Red cell distribution width, free erythrocyte protoporphyrin, and England-Fraser index in the differential diagnosis of microcytosis due to iron deficiency or beta-thalassemia trait. A study of 200 cases of microcytic anemia. (2050603)
1991
44
A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. (2620095)
1989
45
Adult celiac disease (celiac sprue), pernicious anemia and IgA deficiency. Case report and review of the relationships between vitamin B12 deficiency, small intestinal mucosal disease and immunoglobulin deficiency. (3734360)
1986
46
Hereditary dihydrofolate reductase deficiency with megaloblastic anemia. (4080268)
1985
47
Hemolytic anemia with pyruvate kinase deficiency presenting as paravertebral myelolipoma. (6708396)
1984
48
Hemolytic anemia, recurrent metabolic acidosis, and incomplete albinism associated with glutathione synthetase deficiency. (6882923)
1983
49
Is trichuriasis associated with iron deficiency anemia? (464198)
1979
50
Unusual morphologic abnormalities of megaloblasts in pernicious anemia and folate deficiency. (766607)
1976

Genetic Variations for Deficiency Anemia

Expression for genes affiliated with Deficiency Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Deficiency Anemia

Search GEO for disease gene expression data for Deficiency Anemia.

Pathways for genes affiliated with Deficiency Anemia

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Deficiency Anemia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1fenton4510.7HBG2
2deferiprone4510.6TF, EPO, TFRC
3aluminium45 1111.6TF, TFRC, EPO
4iron dextran45 1111.6TFRC, EPO, TF
5bismuth45 2411.5LTF, TF, TFRC
6apotransferrin4510.5LTF, TF, TFRC
723-diphosphoglycerate4510.5EPO, HBG2, G6PD
8protoporphyrin ix45 11 2412.5TFRC, TF, FECH, EPO
9aluminium citrate4510.5TFRC, TF
10succinylacetone4510.4TFRC, TF, EPO, IREB2
11recormon4510.4EPO, TF
12fecl34510.4TF, LTF
13zinc protoporphyrin4510.4FECH, EPO, G6PD, TF, TFRC
14copper45 2411.4SLC40A1, SLC11A2, FECH, HEPH
15ribavirin45 50 1112.4TF, EPO, LTF, G6PD
16haem4510.4FECH, HFE, SLC11A2
17ferric gluconate4510.4TF, EPO
18hydroxyurea45 50 1112.3EPO, HBG2, THPO, TFRC
19malondialdehyde4510.3EPO, PON1, HBG2, G6PD
20sialic acid4510.3TFRC, LTF, EPO, THPO, TF
21cis-aconitate4510.3LTF, ACO1
22ferric ammonium citrate4510.3TFRC, TF, IREB2, LTF, ACO1
23uric acid45 2411.3HBG2, G6PD, HFE, PON1
24oxygen45 2411.3IREB2, HAMP, EPO, ACO1
25folate4510.3TFRC, EPO, G6PD, PON1, TF
268-aminoquinoline4510.3G6PD, HBG2
27alpha tocopherol4510.3HBG2, PON1, TF, G6PD
28n-ethylmaleimide45 1111.2ACO1, HBG2, TFRC, G6PD, IREB2
29polyethylene glycol4510.2PON1, TF, THPO, HBG2, TFRC, G6PD
30vitamin b124510.2PON1, G6PD, EPO, TFRC, TF, LTF
31peroxynitrite4510.2HBG2, IREB2, PON1, ACO1
32polysaccharide4510.2THPO, TFRC
335-aminolevulinic acid45 2411.2SLC11A2, HFE, TFRC, IREB2, ACO1, FECH
34lactate4510.2THPO, EPO, TF, G6PD, TFRC, HBG2
35sodium nitroprusside4510.2IREB2, HBG2, TFRC, G6PD, TF, ACO1
36superoxide45 2411.2THPO, FECH, ACO1, HBG2, G6PD, LTF
37aspartate4510.1TFRC, LTF, EPO, HFE, G6PD, TF
38iron-sulfur4510.1IREB2, ACO1, FECH
39citrate4510.0SLC11A2, TF, TFRC, LTF, ACO1, IREB2
40fe3+4510.0ACO1, SLC11A2, HBG2, LTF, TFRC, TF
41alanine4510.0TF, TFRC, FECH, THPO, HBG2, LTF
42n acetylcysteine459.9G6PD, SLC11A2, HBG2, LTF, TFRC, ACO1
43ascorbic acid45 2410.9HFE, G6PD, SLC11A2, TF, TFRC, PON1
44creatinine459.9LTF, THPO, TFRC, HBG2, TF, EPO
45h2o2459.9THPO, G6PD, HBG2, IREB2, TFRC, PON1
46tocopherol459.9G6PD, HBG2, TF
47cysteine459.8PON1, ACO1, LTF, TFRC, HBG2, HFE
48fe2+459.7TFRC, HFE, TF, FECH, PON1, LTF
49deferoxamine45 1110.7FECH, IREB2, ACO1, HBG2, EPO, LTF
50iron45 249.9TF, TFR2, HAMP, IREB2, HFE2, HEPH

GO Terms for genes affiliated with Deficiency Anemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.2SLC11A2, HFE, TF
2recycling endosomeGO:05503710.2TF, HFE, SLC11A2
3perinuclear region of cytoplasmGO:0484719.8SLC11A2, HFE, TFRC, TF, HEPH
4integral to plasma membraneGO:0058879.8TFRC, TMPRSS11A, SLC40A1, SLC11A2, HFE, TFR2
5extracellular regionGO:0055769.4TMPRSS11A, TF, EPO, LTF, PON1, TFRC

Biological processes related to Deficiency Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.3SLC40A1, SLC11A2, HFE
2iron ion homeostasisGO:05507210.3FECH, HFE2, TMPRSS6
3response to iron(II) ionGO:01004010.3ACO1, IREB2
4copper ion transportGO:00682510.2SLC11A2, HEPH
5iron ion transportGO:00682610.1HEPH, IREB2, TFR2, LTF
6intestinal absorptionGO:05089210.1ACO1, IREB2
7proteolysisGO:00650810.0TFR2, TFRC, LTF, TMPRSS6, TMPRSS11A
8erythrocyte maturationGO:04324910.0EPO, G6PD
9transmembrane transportGO:0550859.9HEPH, TF, TFRC, SLC11A2, SLC40A1
10cellular iron ion homeostasisGO:0068799.4ACO1, HEPH, IREB2, HAMP, TF, TFR2

Molecular functions related to Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.3LTF, TF
2transferrin receptor activityGO:00499810.2TFRC, TFR2
3iron-responsive element bindingGO:03035010.1ACO1, IREB2, FECH
4hormone activityGO:0051799.9THPO, EPO, HAMP
5protein bindingGO:0055158.9TFRC, TF, G6PD, IREB2, FECH, HFE

Products for genes affiliated with Deficiency Anemia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Deficiency Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet