Aliases & Classifications for Deficiency Anemia

MalaCards integrated aliases for Deficiency Anemia:

Name: Deficiency Anemia 39 12 14
Anemia 39 12 72 29 52 41 42 14 69
Deficiency Anemias 12 69
Unspecified Deficiency Anemia 12
Deficiency Anemias Nos 12
Anaemia 12


Summaries for Deficiency Anemia

MedlinePlus : 41 if you have anemia, your blood does not carry enough oxygen to the rest of your body. the most common cause of anemia is not having enough iron. your body needs iron to make hemoglobin. hemoglobin is an iron-rich protein that gives the red color to blood. it carries oxygen from the lungs to the rest of the body. anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction. conditions that may lead to anemia include heavy periods pregnancy ulcers colon polyps or colon cancer inherited disorders a diet that does not have enough iron, folic acid or vitamin b12 blood disorders such as sickle cell anemia and thalassemia, or cancer aplastic anemia, a condition that can be inherited or acquired g6pd deficiency, a metabolic disorder anemia can make you feel tired, cold, dizzy, and irritable. you may be short of breath or have a headache. your doctor will diagnose anemia with a physical exam and blood tests. treatment depends on the kind of anemia you have. nih: national heart, lung, and blood institute

MalaCards based summary : Deficiency Anemia, also known as anemia, is related to pyruvate kinase deficiency and choroiditis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Deficiency Anemia is TMPRSS6 (Transmembrane Protease, Serine 6), and among its related pathways/superpathways are Insulin receptor recycling and Jak-STAT signaling pathway (KEGG). The drugs Iron and Zinc have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.

Related Diseases for Deficiency Anemia

Diseases related to Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
id Related Disease Score Top Affiliating Genes
1 pyruvate kinase deficiency 30.8 EPO G6PD HBG2 HFE
2 choroiditis 30.2 ALB CRP IL6
3 pulmonary embolism 30.0 ALB CRP IL6
4 sickle cell anemia 29.2 EPO G6PD HBB HBG2 HFE TF
5 malaria 28.9 ALB CRP CSF3 EPO G6PD HAMP
6 aplastic anemia 12.2
7 iron-refractory iron deficiency anemia 12.2
8 diamond-blackfan anemia 12.2
9 iron deficiency anemia 12.2
10 folic acid deficiency anemia 11.9
11 protein-deficiency anemia 11.8
12 hereditary orotic aciduria without megaloblastic anaemia 11.8
13 pyridoxine deficiency anemia 11.8
14 autoimmune hemolytic anemia 11.3
15 hereditary elliptocytosis 11.2
16 anemia, sideroblastic, 1 11.1
17 dermatoosteolysis, kirghizian type 11.0 HFE TF
18 virilizing ovarian tumor 11.0 EPO IL6
19 klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism 11.0 EPO HFE2 TMPRSS6
20 microcytic anemia 11.0
21 collagenopathy type 2 alpha 1 10.9 CRP IL6
22 gastric antral vascular ectasia 10.9
23 plummer vinson syndrome 10.9
24 autoimmune atrophic gastritis 10.9
25 harp syndrome 10.9 CRP HFE TF
26 acute radiation syndrome 10.9 G6PD HBG2
27 diarrhea 1, secretory chloride, congenital 10.9 HFE TFR2
28 hepatitis b reinfection following liver transplantation 10.9 HBB HBG2
29 peripheral vascular disease 10.9 G6PD HBG2
30 myeloid sarcoma 10.9 CRP IL6 THPO
31 early-onset zonular cataract 10.9 CP IL6 TF
32 unclassified vasculitis 10.9 HBB HBG2
33 cerebral sarcoidosis 10.8 ALB EPO TF
34 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 10.8 EPO EPOR THPO
35 ehlers-danlos syndrome, type iv 10.8 SLC40A1 TFR2
36 conjunctival vascular disease 10.8 ALB EPO TFRC
37 childhood brain stem glioma 10.8 ALB EPO THPO
38 myoclonic encephalopathy of infants 10.8 ALB CP
39 ovarian cyst 10.8 CP HFE
40 crystal arthropathies 10.8 CRP IL6
41 hereditary multiple osteochondromas 10.8 HFE HFE2 SLC11A2 TFR2
42 granulomatous hepatitis 10.8 CRP EPO IL6 THPO
43 anemia, hemolytic, due to umph1 deficiency 10.8
44 spastic entropion 10.8 ALB CRP TF
45 chronic laryngitis 10.8 HBB THPO
46 bladder sarcoma 10.8 ALB IL6 TF
47 iron metabolism disease 10.8
48 shoulder impingement syndrome 10.8 CRP IL6
49 brain meningioma 10.7 ALB EPO IL6
50 porphyria cutanea tarda 10.7 HAMP HFE HFE2 TF TFRC

Comorbidity relations with Deficiency Anemia via Phenotypic Disease Network (PDN): (show top 50) (show all 337)

3-Hydroxyacyl-Coa Dehydrogenase Deficiency Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Conjunctivitis
Acute Cystitis Acute Kidney Failure
Acute Leukemia Acute Maxillary Sinusitis
Acute Myocardial Infarction Acute Pancreatitis
Acute Proliferative Glomerulonephritis Adjustment Disorder
Adrenal Gland Disease Agammaglobulinemia, X-Linked 1
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Alcoholic Neuropathy Alzheimer Disease
Amyloidosis Anus Cancer
Anxiety Disorder Aortic Aneurysm
Aortic Atherosclerosis Aplastic Anemia
Asbestosis Ascending Colon Cancer
Aspergillosis Atrioventricular Block
Atrophic Gastritis Atypical Depressive Disorder
Autoimmune Hemolytic Anemia Autonomic Nervous System Disease
Bacteremia Basilar Artery Insufficiency
Benign Essential Hypertension Benign Hypertensive Renal Disease
Biliary Tract Neoplasm Bleeding Disorder, Platelet-Type, 11
Blepharitis Blood Platelet Disease
Bronchiectasis Bronchitis
Bronchopneumonia Bullous Pemphigoid
Candidiasis Cardiac Arrest
Cardiogenic Shock Cardiomyopathy, Familial Hypertrophic

Graphical network of the top 20 diseases related to Deficiency Anemia:

Diseases related to Deficiency Anemia

Symptoms & Phenotypes for Deficiency Anemia

UMLS symptoms related to Deficiency Anemia:

angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Deficiency Anemia:

id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 G6PD HFE HFE2 IL6 SLC11A2 SLC40A1
2 homeostasis/metabolism MP:0005376 10.16 ALB CP CRP EPO EPOR G6PD
3 cardiovascular system MP:0005385 10.11 CP CRP EPO EPOR G6PD HFE2
4 immune system MP:0005387 10 CSF3 EPO EPOR HFE HFE2 IL6
5 integument MP:0010771 9.56 SLC40A1 TFRC TMPRSS6 CSF3 EPO HFE2
6 liver/biliary system MP:0005370 9.4 ALB CP EPO EPOR HFE HFE2

Drugs & Therapeutics for Deficiency Anemia

Drugs for Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 5460373 44475014
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
Halofantrine Approved Phase 4 69756-53-2 37393
Copper Approved Phase 4 7440-50-8 27099
Selenium Approved, Vet_approved Phase 4 7782-49-2
Glycerol Approved, Investigational Phase 4 56-81-5 753
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 50-81-7 5785 54670067
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 68-19-9 44176380
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
20 Tocopherol Approved, Nutraceutical Phase 4,Phase 1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-02-9 14985
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
Iodine Investigational Phase 4 7553-56-2 807
26 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1
27 Ferric oxide, saccharated Phase 4,Phase 3,Phase 2,Phase 1
28 Hematinics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Teferrol Phase 4,Phase 3
32 Retinol palmitate Phase 4,Phase 3,Phase 2
33 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Ferrous gluconate Phase 4
35 Antioxidants Phase 4,Phase 3,Phase 1
Bilirubin Phase 4 635-65-4 5280352
37 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Protective Agents Phase 4,Phase 3,Phase 1
39 Vitamin B 12 Phase 4,Phase 2,Phase 3
40 Vitamin B Complex Phase 4,Phase 3,Phase 2
41 Antacids Phase 4,Phase 1
42 Anti-Ulcer Agents Phase 4,Phase 1
43 Gastrointestinal Agents Phase 4,Phase 1
Proton pump inhibitors Phase 4
45 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
46 Blood Substitutes Phase 4,Phase 3,Phase 2,Phase 1
47 Dextrans Phase 4,Phase 3,Phase 2,Phase 1
48 Iron-Dextran Complex Phase 4,Phase 3,Phase 2,Phase 1
49 Plasma Substitutes Phase 4,Phase 3,Phase 2,Phase 1
50 Ferrosoferric Oxide Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 413)

id Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Unknown status NCT00694954 Phase 4
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
5 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
6 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
7 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
8 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4 vitamin B12
9 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
10 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
11 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
12 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
13 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
14 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
15 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
16 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
17 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
18 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
19 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
20 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
21 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
22 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
23 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
24 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
25 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
26 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
27 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
28 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
29 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
30 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
31 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
32 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
33 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
34 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
35 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
36 Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients Completed NCT02214563 Phase 4
37 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
38 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
39 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
40 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
41 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4 Captafer®;Iron Sulfate
42 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
43 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Recruiting NCT03236246 Phase 4 KRX-0502
44 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Recruiting NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
45 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
46 to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants Recruiting NCT03171324 Phase 4 Iron Supplement
47 Iron Treatment for Young Children With Non-anemic Iron Deficiency Recruiting NCT01481766 Phase 4
48 Intravenous Iron Isomaltoside 1000 (Monofer®) Compared With Oral Iron in the Treatment of Postgastrectomy Anemia: An Open-label Randomized Controlled Trial Recruiting NCT03229954 Phase 4 iron isomaltoside (Monofer) intravenous infusion;Ferrous sulfate(Feroba-YOU) per oral
49 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Recruiting NCT01953107 Phase 4
50 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion

Search NIH Clinical Center for Deficiency Anemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: anemia

Genetic Tests for Deficiency Anemia

Genetic tests related to Deficiency Anemia:

id Genetic test Affiliating Genes
1 Anemia 29

Anatomical Context for Deficiency Anemia

MalaCards organs/tissues related to Deficiency Anemia:

Kidney, Heart, Colon, Testes, Lung, Brain, Bone

Publications for Deficiency Anemia

Articles related to Deficiency Anemia:

(show top 50) (show all 795)
id Title Authors Year
A budget impact analysis of parenteral iron treatments for iron deficiency anemia in the UK: reduced resource utilization with iron isomaltoside 1000. ( 28848355 )
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. ( 28052413 )
Curative resectability of gastrointestinal cancer identified from iron deficiency anemia. ( 28943943 )
Ability of serum ferritin to diagnose iron deficiency anemia in an elderly cohort. ( 28830601 )
Effects of Ferric Citrate in Patients with Nondialysis-Dependent CKD and Iron Deficiency Anemia. ( 28082519 )
Enhanced nickel sensitivity in iron deficiency anemia. ( 28928308 )
Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort. ( 28833205 )
Delusional parasitosis secondary to severe iron deficiency anemia. ( 28879221 )
Correction to: Carvalho et al., Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease. ( 28853335 )
Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence. ( 28854239 )
Comparison of Different Iron Preparations in the Prophylaxis of Iron-deficiency Anemia. ( 28872486 )
Idiopathic Pulmonary Hemosiderosis Mimicking Iron Deficiency Anemia: A Delayed Diagnosis? ( 28670434 )
Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children. ( 28667789 )
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. ( 28073037 )
Author's reply: Directly observed iron supplementation for control of iron deficiency anemia. ( 28928309 )
Reply: Intravenous Ferumoxytol in Pediatric Patients With Iron-Deficiency Anemia. ( 28831808 )
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. ( 28934514 )
Primary care physicians are under-testing for celiac disease in patients with iron deficiency anemia: Results of a national survey. ( 28931034 )
Total dose iron dextran infusion versus oral iron for treating iron deficiency anemia in pregnant women: a randomized controlled trial. ( 28901214 )
Comment: Intravenous Ferumoxytol in Pediatric Patients With Iron Deficiency Anemia. ( 28925297 )
Iron Refractory Iron Deficiency Anemia in Dizygotic Twins Due to a Novel TMPRSS6 Gene Mutation in Addition to Polymorphisms Associated With High Susceptibility to Develop Ferropenic Anemia. ( 28491880 )
Challenges in the diagnosis of iron deficiency anemia in aged people. ( 28830594 )
Assessment of the Matos & Carvalho index for distinguishing thalassemia from iron deficiency anemia. ( 28830614 )
Oxidative Stress, Hepcidin and Nesfatin-I Status in Childhood Iron and Vitamin B12 Deficiency Anemias. ( 28691407 )
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
Prevalence of Iron Deficiency and Iron Deficiency Anemia in the Northern and Southern Provinces of Rwanda. ( 28826251 )
The Relationship Between Iron Deficiency Anemia and Sensorineural Hearing Loss in the Pediatric and Adolescent Population. ( 28492865 )
Ferric carboxymaltose reduces the number of red blood cell units transfused and allows transfusion independence to be obtained in patients with iron deficiency anemia secondary to gastrointestinal chronic blood loss. ( 27600706 )
Gastroduodenal lesions in iron-deficiency anemia. ( 27852537 )
Impact of iron deficiency anemia on the function of the immune system in children. ( 27893677 )
Pediatric Crohn's disease, iron deficiency anemia and intravenous iron treatment: a follow-up study. ( 27576956 )
A Curious Case of Iron-Deficiency Anemia. ( 27446874 )
Cost-Effectiveness of Price Subsidies on Fortified Packaged Infant Cereals in Reducing Iron Deficiency Anemia in 6-23-Month-Old-Children in Urban India. ( 27073892 )
Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia. ( 27092272 )
Coexistence of Essential Thrombocythemia, Iron-Refractory Iron Deficiency Anemia and Renal Cell Carcinoma. ( 27103977 )
A new index to discriminate between iron deficiency anemia and thalassemia trait. ( 27521859 )
A 5-Year Follow-Up of Study Patients With Asymptomatic Iron-Deficiency Anemia Using a Nurse-Led Pathway. ( 27922517 )
Severe childhood caries associated with iron deficiency anemia: a case report. ( 27148650 )
The association between subjective assessment of menstrual bleeding and measures of iron deficiency anemia in premenopausal African-American women: a cross-sectional study. ( 27524363 )
Usefulness of Reticulocyte Hemoglobin Equivalent in Management of Regular Hemodialysis Patients with Iron Deficiency Anemia. ( 27141568 )
Hemodynamic response to treatment of iron deficiency anemia in pulmonary arterial hypertension: longitudinal insights from an implantable hemodynamic monitor. ( 28090307 )
Breastfeeding, Mixed, or Formula Feeding at 9 Months of Age and the Prevalence of Iron Deficiency and Iron Deficiency Anemia in Two Cohorts of Infants in China. ( 27836288 )
Prevalence of Thalassemia Trait & Iron Deficiency Anemia during Infancy in 2011-2013 in a Thalassemia Prevalent Region: North Cyprus. ( 27928530 )
Prevalence and Risk Factors for Iron Deficiency Anemia and Iron Depletion During Pregnancy: A Prospective Study. ( 28060688 )
Response to parenteral iron therapy distinguish unexplained refractory iron deficiency anemia from iron-refractory iron deficiency anemia. ( 26818204 )
Iron deficiency anemia in infants and toddlers. ( 28090490 )
A rare case of iron-deficiency anemia rapidly progressing to a life-threatening event. ( 27124228 )
Iron Refractory Iron Deficiency Anemia (IRIDA): A heterogeneous disease that is not always iron refractory. ( 27643674 )
Iron-refractory iron deficiency anemia (IRIDA) cases with 2 novel TMPRSS6 mutations. ( 27120435 )

Variations for Deficiency Anemia

ClinVar genetic disease variations for Deficiency Anemia:

id Gene Variation Type Significance SNP ID Assembly Location
1 HBB; HBD NG_000007.3: g.63632_71046del7415 deletion Pathogenic GRCh38 Chromosome 11, 5226570: 5233984

Expression for Deficiency Anemia

Search GEO for disease gene expression data for Deficiency Anemia.

Pathways for Deficiency Anemia

Pathways related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
3 11.8 CSF3 EPO IL6 THPO
4 11.7 EPO IL6 TF TFRC
Show member pathways
11.69 CP SLC11A2 SLC40A1
7 11.44 CP EPO TF TFRC
8 11.41 SLC11A2 SLC40A1 TF
9 11.38 CSF3 HBB IL6
10 11.35 EPO IL6 TF
11 11.33 CSF3 EPO IL6
12 11.26 CP SLC11A2 SLC40A1 TF TFRC
13 10.18 HAMP SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Deficiency Anemia

Cellular components related to Deficiency Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ALB CP CRP CSF3 EPO HAMP
2 external side of plasma membrane GO:0009897 9.73 HFE IL6 TFR2 TFRC
3 recycling endosome GO:0055037 9.67 HFE SLC11A2 TF TFRC
4 blood microparticle GO:0072562 9.63 ALB CP HBB HBG2 TF TFRC
5 basal part of cell GO:0045178 9.5 HFE SLC11A2 TF
6 hemoglobin complex GO:0005833 9.4 HBB HBG2
7 HFE-transferrin receptor complex GO:1990712 9.02 HFE HFE2 TF TFR2 TFRC
8 extracellular region GO:0005576 10.03 ALB CP CRP CSF3 EPO EPOR

Biological processes related to Deficiency Anemia according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.87 ALB CP IL6 TF
2 receptor-mediated endocytosis GO:0006898 9.84 ALB HBB TFR2 TFRC
3 positive regulation of protein kinase B signaling GO:0051897 9.77 CSF3 IL6 THPO
4 transferrin transport GO:0033572 9.71 HFE TF TFR2 TFRC
5 negative regulation of neuron death GO:1901215 9.69 CSF3 EPO IL6
6 response to iron ion GO:0010039 9.67 HAMP HFE SLC11A2 TFR2
7 acute-phase response GO:0006953 9.63 CRP EPO HAMP HFE IL6 TFR2
8 iron ion transport GO:0006826 9.62 SLC11A2 SLC40A1 TF TFR2
9 cellular response to iron ion GO:0071281 9.61 HFE TF TFR2
10 oxygen transport GO:0015671 9.6 HBB HBG2
11 copper ion transport GO:0006825 9.58 CP SLC11A2
12 erythrocyte maturation GO:0043249 9.58 EPO G6PD
13 negative regulation of lipid storage GO:0010888 9.56 CRP IL6
14 multicellular organismal iron ion homeostasis GO:0060586 9.56 HAMP HFE SLC11A2 SLC40A1
15 positive regulation of peptide hormone secretion GO:0090277 9.55 HFE TFR2
16 iron ion transmembrane transport GO:0034755 9.52 SLC11A2 SLC40A1
17 iron ion homeostasis GO:0055072 9.5 HFE HFE2 SLC11A2 SLC40A1 TF TFR2
18 erythropoietin-mediated signaling pathway GO:0038162 9.49 EPO EPOR
19 response to iron ion starvation GO:1990641 9.48 HAMP HFE
20 ferrous iron import across plasma membrane GO:0098707 9.46 TF TFR2
21 cellular iron ion homeostasis GO:0006879 9.32 CP HAMP HFE HFE2 SLC11A2 SLC40A1
22 transport GO:0006810 10.21 ALB CP HBB HBG2 HFE SLC11A2

Molecular functions related to Deficiency Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.43 ALB HBB HBG2
2 oxygen transporter activity GO:0005344 9.4 HBB HBG2
3 co-receptor binding GO:0039706 9.37 HFE TFR2
4 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
5 ferrous iron transmembrane transporter activity GO:0015093 9.16 SLC11A2 SLC40A1
6 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
7 transferrin receptor binding GO:1990459 8.8 HFE HFE2 TF

Sources for Deficiency Anemia

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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