MCID: DGN001
MIFTS: 41

Degenerative Disc Disease malady

Summaries for Degenerative Disc Disease

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Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to cervicitis and spondylosis. An important gene associated with Degenerative Disc Disease is ASPN (asporin). Affiliated tissues include intervertebral disc, bone and bone marrow.

Wikipedia:63 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:46 603932

Aliases & Classifications for Degenerative Disc Disease

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

degenerative disc disease 8 10 44 30
lumbar disc degeneration 8 46
degeneration of lumbar intervertebral disc 60
cervical disc degenerative disorder 60
cervical disc degenerative disease 8
intervertebral disc degeneration 60
intervertebral disc disorder 60
vertebral disc disease 8


External Ids:

Disease Ontology8 DOID:90
NCIt39 C27156
SNOMED-CT56 156633005
ICD1025 M51.8

Related Diseases for Degenerative Disc Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis10.9
2spondylosis10.5
3osteoporotic fracture10.3
4chronic cervicitis10.3
5collagen disease10.3
6intervertebral disc disease10.3
7spondylolysis10.2
8spondyloepiphyseal dysplasia with congenital joint dislocations10.2
9hyperostosis10.2
10atherosclerosis10.2
11breast disease10.1
12cystitis10.1
13obesity10.1
14osteomyelitis10.1
15pancreatitis10.1
16metabolic acidosis10.1

Graphical network of diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Clinical Features for Degenerative Disc Disease

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46OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Degenerative Disc Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Degenerative Disc Disease

Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Search CenterWatch for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Degenerative Disc Disease:

32
Bone, Bone marrow, Breast, Testes

FMA organs/tissues related to Degenerative Disc Disease:

14
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

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Publications for Degenerative Disc Disease

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Sources:
50PubMed
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Articles related to Degenerative Disc Disease:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse magnetic resonance imaging analysis of 224 patients. (24231779)
2014
2
Artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials. (24323061)
2014
3
Dynamic stabilisation in the treatment of degenerative disc disease with modic changes. (23781343)
2013
4
Adolescent lumbar disc herniation: experience from a large minimally invasive treatment centre for lumbar degenerative disease in Chongqing, China. (23419406)
2013
5
Instrumented Posterior Lumbar Interbody Fusion (PLIF) with Interbody Fusion Device (Cage) in Degenerative Disc Disease (DDD): 3 Years Outcome. (24292314)
2013
6
Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials. (23645003)
2013
7
Clinical and radiologic comparison of dynamic cervical implant arthroplasty versus anterior cervical discectomy and fusion for the treatment of cervical degenerative disc disease. (24411326)
2013
8
Posterior Transpedicular Dynamic Stabilization versus Total Disc Replacement in the Treatment of Lumbar Painful Degenerative Disc Disease: A Comparison of Clinical Results. (23401784)
2013
9
Massage therapy for cervical degenerative disc disease: alleviating a pain in the neck? (23087777)
2012
10
Lumbar degenerative disc disease: current and future concepts of diagnosis and management. (22567411)
2012
11
Diagnostic testing for degenerative disc disease. (22844603)
2012
12
Intradiscal pulsed radiofrequency application following provocative discography for the management of degenerative disc disease and concordant pain: a pilot study. (22008239)
2012
13
Regarding: intradiscal pulsed radiofrequency application following provocative discography for the management of degenerative disc disease and concordant pain: a pilot study. (22672242)
2012
14
Five-year results of the prospective, randomized, multicenter, Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential arthrodesis for the treatment of single-level degenerative disc disease. (23082846)
2012
15
Clinical outcome of lumbar total disc replacement using ProDisc-L in degenerative disc disease: minimum 5-year follow-up results at a single institute. (21857395)
2012
16
Tissue engineering approaches to degenerative disc disease--a meta-analysis of controlled animal trials. (22789805)
2012
17
Epidural abscess and cauda equina syndrome after percutaneous intradiscal therapy in degenerative lumbar disc disease. (23131581)
2012
18
Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study. (21311928)
2011
19
Impact of total disc arthroplasty on the surgical management of lumbar degenerative disc disease: Analysis of the Nationwide Inpatient Sample from 2000 to 2008. (22059134)
2011
20
Anterior discectomies and interbody cage fusion without plate fixation for 5-level cervical degenerative disc disease: a 5-year follow-up. (22005163)
2011
21
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (22724162)
2011
22
Optimization of protein crosslinking formulations for the treatment of degenerative disc disease. (20595926)
2011
23
Effect of deep wound infection following lumbar arthrodesis for degenerative disc disease on long-term outcome: a prospective study: clinical article. (21682558)
2011
24
TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. (21445993)
2011
25
Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease: a systematic review. (21403782)
2011
26
Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. (20091597)
2010
27
Total disc replacement surgery for symptomatic degenerative lumbar disc disease: a systematic review of the literature. (20508954)
2010
28
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (18411503)
2008
29
Follow-up study on the motion range after treatment of degenerative disc disease with the Bryan cervical disc prosthesis. (17497290)
2007
30
Adjacent segment degeneration following spinal fusion for degenerative disc disease. (17539759)
2007
31
Controversial topics in surgery: degenerative disc disease: disc replacement. Against. (17326280)
2007
32
Juvenile degenerative disc disease: a report of 76 cases identified by magnetic resonance imaging. (17482117)
2007
33
Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. (17088711)
2006
34
Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. (16648751)
2006
35
Surgical treatment of degenerative disc disease using anterior or posterior interbody fusion. (17675984)
2004
36
The "tract" of history in the treatment of lumbar degenerative disc disease. (15264785)
2004
37
A new classification system for degenerative disc disease of the lumbar spine based on magnetic resonance imaging, provocative discography, plain radiographs and anatomic considerations. (15541662)
2004
38
Combined anterior interbody fusion and posterior pedicle screw fixation in patients with degenerative lumbar disc disease. (15309326)
2004
39
Uninstrumented posterolateral lumbar fusion for single level isolated disc resorption and/or degenerative disc disease. (10078947)
1999
40
Cervical monosegmental interbody fusion using titanium implants in degenerative, intervertebral disc disease. (10228933)
1999
41
Familial predisposition for lumbar degenerative disc disease. A case-control study. (9589542)
1998
42
The safety and efficacy of the Isola Spinal Implant System for the surgical treatment of degenerative disc disease. A prospective study. (8726203)
1996
43
Spinal fusion in degenerative disc disease. (8076465)
1994
44
Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain. (8083266)
1994
45
Comparison of MRI and discography in the diagnosis of lumbar degenerative disc disease. (1490039)
1992
46
Clinical efficacy of spinal instrumentation in lumbar degenerative disc disease. (1502650)
1992
47
Severity of disability due to occupational low back injury after lumbar laminectomy for degenerative disc disease. (2348264)
1990
48
Centrode patterns and segmental instability in degenerative disc disease. (3992346)
1985
49
The Pennsylvania Plan. An algorithm for the management of lumbar degenerative disc disease. (264030)
1979
50
Proceedings: Intervertebral disc collagen in degenerative disc disease. (1221933)
1975

Genetic Variations for Degenerative Disc Disease

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Degenerative Disc Disease:

62
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Degenerative Disc Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Compounds for genes affiliated with Degenerative Disc Disease

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GO Terms for genes affiliated with Degenerative Disc Disease

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Products for genes affiliated with Degenerative Disc Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Degenerative Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet