MCID: DGN001
MIFTS: 61

Degenerative Disc Disease malady

Genetic diseases (common), Bone diseases categories

Summaries for Degenerative Disc Disease

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to spondylolisthesis and osteoarthritis. An important gene associated with Degenerative Disc Disease is ASPN (asporin), and among its related pathways are Elastic fibre formation and Phenylalanine metabolism. The compounds polyglycolic acid and chitosan have been mentioned in the context of this disorder. Affiliated tissues include intervertebral disc, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:66 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:48 603932

Aliases & Classifications for Degenerative Disc Disease

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 41NCIt, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Bone diseases


Aliases & Descriptions:

degenerative disc disease 9 11 46 32
lumbar disc degeneration 9 48
degeneration of lumbar intervertebral disc 63
cervical disc degenerative disorder 63
cervical disc degenerative disease 9
intervertebral disc degeneration 63
intervertebral disc disorder 63
vertebral disc disease 9


External Ids:

Disease Ontology9 DOID:90
NCIt41 C27156
SNOMED-CT59 156633005
ICD1026 M51.8

Related Diseases for Degenerative Disc Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Symptoms for Degenerative Disc Disease

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48OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Degenerative Disc Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Degenerative Disc Disease

Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Search CenterWatch for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards, 15FMA
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MalaCards organs/tissues related to Degenerative Disc Disease:

34
Bone, Breast, Testes

FMA organs/tissues related to Degenerative Disc Disease:

15
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Degenerative Disc Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8SOX9, BMP2, ACAN, VDR
2MP:00053718.7VDR, GDF5, SOX9, ACAN, BMP2
3MP:00053908.7BMP2, GDF5, SOX9, ACAN, VDR
4MP:00053897.8TBPL1, COMT, BMP2, SOX9, VDR, GDF5

Publications for Degenerative Disc Disease

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Sources:
53PubMed
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Articles related to Degenerative Disc Disease:

(show top 50)    (show all 204)
idTitleAuthorsYear
1
Letter regarding article by Wei et al.: Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomised controlled trials. (24178062)
2014
2
Dynamic stabilisation in the treatment of degenerative disc disease with modic changes. (23781343)
2013
3
Motion characteristics of the lumbar spinous processes with degenerative disc disease and degenerative spondylolisthesis. (23903997)
2013
4
Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease. (23951558)
2013
5
The fuzzy logic of degenerative disc disease: from a Lorenz attractor to a percolation threshold model. (23689128)
2013
6
Instrumented Posterior Lumbar Interbody Fusion (PLIF) with Interbody Fusion Device (Cage) in Degenerative Disc Disease (DDD): 3 Years Outcome. (24292314)
2013
7
Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. (24010901)
2013
8
The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. (24003854)
2013
9
Differences between arthroplasty and anterior cervical fusion in two-level cervical degenerative disc disease. (24318106)
2013
10
Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease. (23622053)
2013
11
Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials. (23645003)
2013
12
Arthroplasty versus fusion in single-level cervical degenerative disc disease. (22972137)
2012
13
Massage therapy for cervical degenerative disc disease: alleviating a pain in the neck? (23087777)
2012
14
Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients. (21948754)
2011
15
Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study. (21311928)
2011
16
Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. (21249667)
2011
17
Impact of total disc arthroplasty on the surgical management of lumbar degenerative disc disease: Analysis of the Nationwide Inpatient Sample from 2000 to 2008. (22059134)
2011
18
How does lumbar degenerative disc disease affect the disc deformation at the cephalic levels in vivo? (21245781)
2011
19
Anterior discectomies and interbody cage fusion without plate fixation for 5-level cervical degenerative disc disease: a 5-year follow-up. (22005163)
2011
20
Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. (20091597)
2010
21
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies. (24198557)
2010
22
Segment-by-segment stabilization for degenerative disc disease: a hybrid technique. (20130934)
2010
23
Efficacy of post-operative analgesia after posterior lumbar instrumented fusion for degenerative disc disease: a prospective randomized comparison of epidural catheter and intravenous administration of analgesics. (21808704)
2010
24
Lateral lumbar interbody fusion via a unilateral true percutaneous approach associated with minimally invasive pedicle screw fixation for degenerative disc disease and lumbar instability. A technical note. (21313957)
2010
25
Influence of single-level lumbar degenerative disc disease on the behavior of the adjacent segments--a finite element model study. (19136113)
2009
26
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (19824220)
2009
27
Follow-up study on the motion range after treatment of degenerative disc disease with the Bryan cervical disc prosthesis. (17497290)
2007
28
Re: Zigler J, Delamarter R, Spivak J, et al. Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. Spine 2007;32:1155-62. (18246024)
2007
29
Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. (17088711)
2006
30
Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs. (16189714)
2006
31
Intradiscal thermal annuloplasty for the treatment of lumbar discogenic pain in patients with multilevel degenerative disc disease. (15271727)
2004
32
Gene therapy for degenerative disc disease. (14724681)
2004
33
Observer variability based on the strength of MR scanners in the assessment of lumbar degenerative disc disease. (15294326)
2004
34
Degenerative disc disease treated with combined anterior and posterior arthrodesis and posterior instrumentation. (12163733)
2002
35
Management of degenerative disc disease above an L5-S1 segment requiring arthrodesis. (10382258)
1999
36
Uninstrumented posterolateral lumbar fusion for single level isolated disc resorption and/or degenerative disc disease. (10078947)
1999
37
A multi-center prospective study of the CD Spinal System in patients with degenerative disc disease. (9884289)
1998
38
Surgical results after soft system stabilization of the lumbar spine in degenerative disc disease--long-term results. (9755317)
1998
39
Case 19. Presentation. Degenerative disc disease at L 4-5, L5-S1 and metastatic breast cancer at L 3. (9492743)
1998
40
Spinal motion in lumbar degenerative disc disease. (9853494)
1998
41
Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. (9020464)
1997
42
The safety and efficacy of the Isola Spinal Implant System for the surgical treatment of degenerative disc disease. A prospective study. (8726203)
1996
43
Orientation of the lumbar facet joints: association with degenerative disc disease. (8613448)
1996
44
The effect of pedicle screw/plate fixation on lumbar/lumbosacral autogenous bone graft fusions in patients with degenerative disc disease. (7701397)
1995
45
Spinal fusion in degenerative disc disease. (8076465)
1994
46
Comparison of MRI and discography in the diagnosis of lumbar degenerative disc disease. (1490039)
1992
47
Computer analysis of spinal segment motion in degenerative disc disease with and without axial loading. (6495026)
1984
48
Autoimmunity in degenerative disc disease of the lumbar spine. (803670)
1975
49
The use of chymopapain in degenerative disc disease: a preliminary report. (5445694)
1970
50
Pain and disability in degenerative disc disease. (5384672)
1969

Variations for Degenerative Disc Disease

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65UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Degenerative Disc Disease:

65
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Degenerative Disc Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9GDF5, BMP2
2
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.4COMT, DCT
39.4COL9A3, COL9A2, ASPN, ACAN
4
Show member pathways
9.3COL9A2, GDF5, BMP2, COL9A3
5
Show member pathways
8.9BMP2, SOX9, COL9A3, GDF5, COL9A2
6
Show member pathways
8.8BMP2, COL9A2, ACAN, ASPN, GDF5, COL9A3

Compounds for genes affiliated with Degenerative Disc Disease

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4610.1ACAN, BMP2
2chitosan4610.1ACAN, BMP2
3alginate469.8SOX9, BMP2, ACAN
4alendronate46 52 1211.7VDR, BMP2
5l-amino acid469.6COMT, GCH1
6vitamin d469.5ACAN, BMP2, VDR
7glycosaminoglycan469.5BMP2, SOX9, ACAN, GDF5
8mptp469.4COMT, GCH1, VDR
9folate469.3GCH1, COMT, VDR
10levodopa46 1210.3COMT, DCT, GCH1
11sb 20358046 6210.2VDR, ACAN, BMP2
12dexamethasone46 52 30 1212.1VDR, BMP2, ACAN, SOX9
13testosterone46 62 25 1211.9COMT, SOX9, BMP2, VDR
14cysteine468.6DCT, COMT, BMP2, GDF5, VDR
15ascorbic acid46 259.5VDR, ACAN, BMP2, COMT, GCH1, SOX9
16retinoic acid46 259.3COMT, ACAN, SOX9, DCT, BMP2, VDR

GO Terms for genes affiliated with Degenerative Disc Disease

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17Gene Ontology
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Cellular components related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IXGO:0055949.6COL9A3, COL9A2
2extracellular regionGO:0055769.0COL9A3, COL9A2, BMP2, ACAN, GDF5

Biological processes related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.0BMP2, SOX9
2bone mineralizationGO:03028210.0ASPN, BMP2
3positive regulation of cartilage developmentGO:06103610.0BMP2, SOX9
4growthGO:04000710.0BMP2, GDF5
5positive regulation of chondrocyte differentiationGO:0323329.9SOX9, GDF5
6extracellular matrix disassemblyGO:0226179.8ACAN, COL9A2, COL9A3
7epithelial to mesenchymal transitionGO:0018379.8SOX9, BMP2
8branching involved in ureteric bud morphogenesisGO:0016589.8BMP2, SOX9
9chondrocyte differentiationGO:0020629.8BMP2, GDF5
10response to painGO:0482659.8GCH1, COMT
11negative regulation of epithelial cell proliferationGO:0506809.4SOX9, GDF5
12skeletal system developmentGO:0015019.1VDR, SOX9, ACAN, BMP2, COL9A2
13extracellular matrix organizationGO:0301988.9COL9A3, COL9A2, BMP2, ACAN, SOX9, GDF5

Molecular functions related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.9COL9A3, COL9A2

Products for genes affiliated with Degenerative Disc Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Degenerative Disc Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet