MCID: DGN001
MIFTS: 52

Degenerative Disc Disease malady

Categories: Bone diseases

Aliases & Classifications for Degenerative Disc Disease

Aliases & Descriptions for Degenerative Disc Disease:

Name: Degenerative Disc Disease 38 12 52 14
Intervertebral Disc Degeneration 12 69
Degeneration of Lumbar Intervertebral Disc 69
Cervical Disc Degenerative Disorder 69
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 69
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 47 C27156
SNOMED-CT 64 156633005
ICD10 33 M51.3
UMLS 69 C0410606

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to intervertebral disc disease and cervicitis, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is ACAN (Aggrecan), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Morphine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia : 71 Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine.... more...

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 11.1
2 cervicitis 10.6
3 back pain 10.3
4 cerebral beriberi 10.2 ASPN COL9A3
5 cerebellar hypoplasia with endosteal sclerosis 10.2 CALCA NPY
6 waardenburg syndrome, type 4b 10.2 CALCA VDR
7 tarsal-carpal coalition syndrome 10.1 BMP2 GDF5
8 low compliance bladder 10.1 BMP2 CALCA
9 acute hemorrhagic leukoencephalitis 10.1 CALCA IVD
10 immunodeficiency, common variable, 12 10.1 BMP2 GDF5
11 stickler syndrome, type v 10.1 ASPN COL9A3 VDR
12 cockayne syndrome type i 10.1 CALCA NPY
13 cranio-facial dystonia 10.1 COMT GCH1
14 spondylolisthesis 10.1
15 dysbaric osteonecrosis 10.1 BMP2 CALCA VDR
16 ischemic bone disease 10.1 BMP2 CALCA VDR
17 pediatric castleman disease 10.1 CALCA NPY
18 hemolytic anemia due to glutathione synthetase deficiency 10.0 ASPN GDF5 MMP3
19 osteopetrosis 10.0 ACAN COL9A3 MMP13
20 epidermolysis bullosa acquisita 10.0 ACAN BMP2 IVD
21 bazex syndrome 10.0 ASPN CALCA
22 radiculopathy 9.9
23 bone angioendothelial sarcoma 9.9 ACAN MMP13 MMP3
24 mental retardation, autosomal recessive 40 9.9 MMP13 MMP3 SOX9
25 syngnathia cleft palate 9.9 ACAN CALCA COL9A3 MMP3
26 osteoarthritis 9.8
27 systemic scleroderma 9.8 BMP2 GDF5 IVD MMP3
28 pancreatitis 9.7
29 thyroiditis 9.7
30 spondylarthropathy 9.7
31 breast cancer 9.7
32 obesity 9.7
33 arthritis 9.7
34 scoliosis 9.7
35 osteomyelitis 9.7
36 cystitis 9.7
37 metabolic acidosis 9.7
38 osteonecrosis 9.6 ACAN ASPN GDF5 MMP13 MMP3 SOX9
39 physical disorder 9.2 ACAN BMP2 COL9A3 GDF5 IVD MMP13
40 bone resorption disease 8.9 ACAN BMP2 COL9A3 GDF5 IVD MMP13
41 dentin dysplasia 8.2 ACAN ASPN BMP2 CALCA COL9A3 COMT

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

MGI Mouse Phenotypes related to Degenerative Disc Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.43 ASPN BMP2 GDF5 MMP13 SOX9 VDR
2 skeleton MP:0005390 9.17 GDF5 MMP13 MMP3 NPY SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 224)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
3
Meloxicam Approved, Vet_approved Phase 4,Phase 3 71125-38-7 5281106 54677470
4
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
5
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
6
Timolol Approved Phase 4 26839-75-8 33624 5478
7
Travoprost Approved Phase 4 157283-68-6 5282226
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Norepinephrine Approved Phase 4 51-41-2 439260
10
Choline Approved, Nutraceutical Phase 4 62-49-7 305
11
Maleic acid Experimental Phase 4 110-16-7 444266
12
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2
13 Analgesics Phase 4,Phase 3
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Analgesics, Non-Narcotic Phase 4,Phase 3
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
18 Antirheumatic Agents Phase 4,Phase 3
19 Cyclooxygenase Inhibitors Phase 4,Phase 3
20 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
21 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
23 Analgesics, Opioid Phase 4,Phase 3
24 Narcotics Phase 4,Phase 3
25 Adrenergic Agents Phase 4
26 Adrenergic Antagonists Phase 4
27 Adrenergic beta-Antagonists Phase 4
28 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
29 Anticoagulants Phase 4,Phase 1
30 Antihypertensive Agents Phase 4
31 Blood Substitutes Phase 4
32 Cloprostenol Phase 4
33 Contraceptive Agents Phase 4
34 Dextrans Phase 4
35 Lubricant Eye Drops Phase 4
36 Luteolytic Agents Phase 4
37 Neurotransmitter Agents Phase 4
38 Ophthalmic Solutions Phase 4
39 Plasma Substitutes Phase 4
40 Tetrahydrozoline Phase 4
41 Cytidine Diphosphate Choline Phase 4
42 Nootropic Agents Phase 4
43 Psychotropic Drugs Phase 4
44 Antidepressive Agents Phase 4
45 Dopamine Agents Phase 4
46 Duloxetine Hydrochloride Phase 4
47 Neurotransmitter Uptake Inhibitors Phase 4
48
Serotonin Phase 4 50-67-9 5202
49 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
50
Benzocaine Approved Phase 3,Phase 1 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 349)
id Name Status NCT ID Phase
1 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
2 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
3 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
4 CHARITE™ vs. ALIF 5-Year Follow-up Completed NCT00215332 Phase 4
5 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
6 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
7 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4
8 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
9 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
10 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
11 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
12 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
13 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
14 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study Completed NCT02895555 Phase 4
15 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4
16 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
17 Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion Recruiting NCT01549366 Phase 4
18 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
19 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
20 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03046693 Phase 4
21 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
22 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Active, not recruiting NCT02535000 Phase 4
23 Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) Active, not recruiting NCT01016314 Phase 4
24 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Active, not recruiting NCT02429908 Phase 4
25 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Active, not recruiting NCT02182843 Phase 4
26 Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine Enrolling by invitation NCT02068729 Phase 4
27 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
28 CARES Lumbar Artificial Disc Registry Terminated NCT02139527 Phase 4
29 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
30 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
31 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
32 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
33 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
34 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
35 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
36 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
37 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
38 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
39 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
40 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
41 LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE Completed NCT00389597 Phase 3
42 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
43 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
44 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3
45 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
46 Post-Approval Clinical Trial of the PCM® Cervical Disc Completed NCT01905930 Phase 3
47 PCM Cervical Disc System Completed NCT00578812 Phase 3
48 Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
49 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
50 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) Completed NCT00943072 Phase 3

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

MalaCards organs/tissues related to Degenerative Disc Disease:

39
Bone, Testes, Breast, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

18
Intervertebral Disc
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 303)
id Title Authors Year
1
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. ( 27902945 )
2017
2
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. ( 28086781 )
2017
3
The usefulness of radiological grading scales to predict pain intensity, functional impairment, and health-related quality of life after surgery for lumbar degenerative disc disease. ( 27873048 )
2017
4
Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease. ( 28002363 )
2017
5
Biochemical validity of imaging techniques (X-ray, MRI, and dGEMRIC) in degenerative disc disease of the human cervical spine-an in vivo study. ( 27568543 )
2016
6
Evaluation of Aesculap Implant Systems activl Artificial Disc for the treatment of degenerative disc disease. ( 27807981 )
2016
7
Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27015130 )
2016
8
Influence of Body Mass Index on Subjective and Objective Measures of Pain, Functional Impairment, and Health-Related Quality of Life in Lumbar Degenerative Disc Disease. ( 27686509 )
2016
9
Disc nucleus fortification for lumbar degenerative disc disease: a biomechanical study. ( 26771371 )
2016
10
Reply: the letter to the editor of Dr. Yan Hu entitled "Re: Gao F, Mao T, Sun W, Guo W, Wang Y, Li Z et al. An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD). Spine (Phila Pa 1976) 2015;40(23): 1816-23." ( 27054456 )
2016
11
Sex differences in lumbar degenerative disc disease. ( 27086119 )
2016
12
Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses. ( 27448810 )
2016
13
Pre- and postoperative correlation of patient-reported outcome measures with standardized Timed Up and Go (TUG) test results in lumbar degenerative disc disease. ( 27488842 )
2016
14
Biological Treatment Approaches for Degenerative Disc Disease: A Review of Clinical Trials and Future Directions. ( 28018762 )
2016
15
Assessment of the Minimum Clinically Important Difference in the Timed Up and Go Test After Surgery for Lumbar Degenerative Disc Disease. ( 27352275 )
2016
16
Influence of age on pain intensity, functional impairment and health-related quality of life before and after surgery for lumbar degenerative disc disease. ( 27579779 )
2016
17
Etiology for Degenerative Disc Disease. ( 27733227 )
2016
18
PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. ( 26901836 )
2016
19
A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolutiona8c) with a comparison to historical controls. ( 26849141 )
2016
20
Return to Work Rates After Single-level Cervical Fusion for Degenerative Disc Disease Compared With Fusion for Radiculopathy in a Workers' Compensation Setting. ( 27398795 )
2016
21
Electromagnetic fields in the treatment of chronic lower back pain in patients with degenerative disc disease. ( 28031951 )
2016
22
Association between nutritional status and Modic classification in degenerative disc disease. ( 27190462 )
2016
23
Women do not fare worse than men after lumbar fusion surgery: Two-year follow-up results from 4,780 prospectively collected patients in the Swedish National Spine Register with lumbar degenerative disc disease and chronic low back pain. ( 27845232 )
2016
24
Correlation of pain, functional impairment, and health-related quality of life with radiological grading scales of lumbar degenerative disc disease. ( 26783024 )
2016
25
Operative Management of Lumbar Degenerative Disc Disease. ( 27559465 )
2016
26
Sagittal balance parameters correlate with spinal conformational type and MRI changes in lumbar degenerative disc disease: results of a retrospective study. ( 27562589 )
2016
27
Diagnosing Discogenic Low Back Pain Associated with Degenerative Disc Disease Using a Medical Interview. ( 27820861 )
2016
28
In vivo Characteristics of Non-degenerated Adjacent Segment Intervertebral Foramina in Patients with Degenerative Disc Disease during Flexion-Extension. ( 27379419 )
2016
29
Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up. ( 26855020 )
2016
30
Patients' Preference of the Timed Up and Go (TUG) Test or Patient-Reported Outcome Measures (PROMs) Before and After Surgery for Lumbar Degenerative Disc Disease. ( 27913260 )
2016
31
The 'Lumbar Fusion Outcome Score' (LUFOS): a new practical and surgically oriented grading system for preoperative prediction of surgical outcomes after lumbar spinal fusion in patients with degenerative disc disease and refractory chronicA axial low back pain. ( 27289367 )
2016
32
Current and future perspectives on lumbar degenerative disc disease: a UK survey exploring specialist multidisciplinary clinical opinion. ( 27633633 )
2016
33
Clinical and radiologic comparison of dynamic cervical implant arthroplasty and cervical total disc replacement for single-level cervical degenerative disc disease. ( 26928156 )
2016
34
Influence of the mental health status on a new measure of objective functional impairment in lumbar degenerative disc disease. ( 27988343 )
2016
35
Association of spinal degenerative disc disease with thyroid autoimmunity. ( 26885680 )
2016
36
Intervertebral Fusion with Mobile Microendoscopic Discectomy for Lumbar Degenerative Disc Disease. ( 27384734 )
2016
37
MRI Phenotyping of COL9A2/Trp2 and COL9A3/Trp3 Alleles in Degenerative Disc Disease: a Case-Control Study in Southwestern Iranian Population Reveals a Significant Trp3-Disease Association in Males. ( 27054457 )
2016
38
Sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease. ( 26761383 )
2016
39
Erratum: Replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27058502 )
2016
40
Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. ( 27163101 )
2016
41
Reply to the Letter to the Editor regarding: "An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD)." Spine (Philaa88Pa 1976). 2015 Dec;40(23): 1816-23. ( 26909830 )
2016
42
Effects of Smoking on Subjective and Objective Measures of Pain Intensity, Functional Impairment and Health-related Quality of Life in Lumbar Degenerative Disc Disease. ( 27888086 )
2016
43
A Pilot Study Of Sequence Of Segmental Contributions In The Lower Cervical Spine During Active Extension And Flexion: Healthy Controls vs. Cervical Degenerative Disc Disease Patients. ( 27879563 )
2016
44
Comparison of anterior cervical discectomy and fusion with the zero-profile device versus plate and cage in treating cervical degenerative disc disease: A meta-analysis. ( 27443497 )
2016
45
What is the Clinical Relevance of Radiographic Nonunion after Single-level Lumbar Interbody Arthrodesis in Degenerative Disc Disease? A Meta-Analysis of the YODA Project Database. ( 26274529 )
2015
46
Magnetic Resonance Imaging Findings in Degenerative Disc Disease of Cervical Spine in Symptomatic Patients. ( 27005711 )
2015
47
Facet joint orientation and tropism in lumbar degenerative disc disease and spondylolisthesis. ( 25958712 )
2015
48
Chronic Opioid Therapy after Lumbar Fusion Surgery for Degenerative Disc Disease in a Workers' Compensation Setting. ( 26192725 )
2015
49
Clinical outcome of stand-alone ALIF compared to posterior instrumentation for degenerative disc disease: A pilot study and a literature review. ( 25855474 )
2015
50
Association of rs2228570 polymorphism of vitamin D receptor gene with degenerative disc disease: a meta-analysis involving 2947 subjects. ( 26885185 )
2015

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 ACAN ASPN BMP2 COL9A3 GDF5 MMP13
2 11.25 ACAN MMP13 SOX9
3 11.24 ACAN BMP2 GDF5 SOX9
4 11.09 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Cellular components related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ACAN ASPN BMP2 CALCA COL9A3 GDF5
2 extracellular space GO:0005615 9.8 ACAN BMP2 CALCA GDF5 MMP13 MMP3
3 proteinaceous extracellular matrix GO:0005578 9.35 ACAN ASPN COL9A3 MMP13 MMP3
4 extracellular matrix GO:0031012 9.02 ACAN ASPN MMP13 MMP3 RPS17

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.61 ACAN MMP13 MMP3
2 regulation of blood pressure GO:0008217 9.58 CALCA GCH1 NPY
3 negative regulation of blood pressure GO:0045776 9.57 CALCA GCH1
4 vasodilation GO:0042311 9.56 CALCA GCH1
5 skeletal system development GO:0001501 9.56 ACAN BMP2 SOX9 VDR
6 negative regulation of ossification GO:0030279 9.55 CALCA SOX9
7 positive regulation of chondrocyte differentiation GO:0032332 9.54 GDF5 SOX9
8 negative regulation of chondrocyte differentiation GO:0032331 9.52 GDF5 SOX9
9 chondrocyte development GO:0002063 9.51 ACAN SOX9
10 chondrocyte differentiation GO:0002062 9.5 BMP2 GDF5 SOX9
11 positive regulation of cartilage development GO:0061036 9.49 BMP2 SOX9
12 endocardial cushion morphogenesis GO:0003203 9.48 BMP2 SOX9
13 positive regulation of ossification GO:0045778 9.46 BMP2 CALCA
14 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.37 GDF5 SOX9
15 bone mineralization GO:0030282 9.33 ASPN BMP2 MMP13
16 response to pain GO:0048265 9.13 CALCA COMT GCH1
17 cartilage development GO:0051216 8.92 BMP2 GDF5 MMP13 SOX9

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.26 BMP2 CALCA GDF5 NPY
2 calcium ion binding GO:0005509 9.02 ACAN ASPN GCH1 MMP13 MMP3

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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