MCID: DGN001
MIFTS: 61

Degenerative Disc Disease malady

Genetic diseases (common), Bone diseases categories
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Summaries for Degenerative Disc Disease

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Disease Ontology:8 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to spondylolisthesis and radiculopathy. An important gene associated with Degenerative Disc Disease is ASPN (asporin), and among its related pathways are Elastic fibre formation and Phenylalanine metabolism. The compounds polyglycolic acid and chitosan have been mentioned in the context of this disorder. Affiliated tissues include intervertebral disc, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:65 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:46 603932

Aliases & Classifications for Degenerative Disc Disease

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Degenerative Disc Disease, Aliases & Descriptions:

Name: Degenerative Disc Disease 30 8 10 44
Lumbar Disc Degeneration 8 46 62
Cervical Disc Degenerative Disorder 62
Cervical Disc Degenerative Disease 8
 
Intervertebral Disc Degeneration 62
Intervertebral Disc Disorder 62
Vertebral Disc Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:90
NCIt39 C27156
SNOMED-CT57 156633005
ICD1025 M51.8

Related Diseases for Degenerative Disc Disease

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Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Symptoms for Degenerative Disc Disease

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Clinical features from OMIM:

603932

Drugs & Therapeutics for Degenerative Disc Disease

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Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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MalaCards organs/tissues related to Degenerative Disc Disease:

32
Bone, Breast, Testes

FMA organs/tissues related to Degenerative Disc Disease:

14
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

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MGI Mouse Phenotypes related to Degenerative Disc Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8VDR, SOX9, ACAN, BMP2
2MP:00053718.7BMP2, ACAN, SOX9, GDF5, VDR
3MP:00053908.7BMP2, ACAN, SOX9, GDF5, VDR
4MP:00053897.8VDR, GDF5, SOX9, BMP2, COMT, TBPL1

Publications for Degenerative Disc Disease

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Articles related to Degenerative Disc Disease:

(show top 50)    (show all 226)
idTitleAuthorsYear
1
End plate disproportion and degenerative disc disease: a case-control study. (25187856)
2014
2
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (24933742)
2014
3
Mesenchymal stem cell technology in the treatment of degenerative disc disease. (25373318)
2014
4
Stand-alone anterior lumbar interbody fusion for degenerative disc disease of the lumbar spine: results with a 2-year follow-up. (24825156)
2014
5
Re: Phillips FM, Slosar PJ, Youssef JA, et al. Systematic review of lumbar spine fusion for chronic low back pain due to degenerative disc disease. Spine (Phila Pa 1976) 2013;38:E409a8922. (24525984)
2014
6
Effects of Spinal Stabilization Exercise on the Cross-sectional Areas of the Lumbar Multifidus and Psoas Major Muscles, Pain Intensity, and Lumbar Muscle Strength of Patients with Degenerative Disc Disease. (24764637)
2014
7
Letter regarding article by Wei et al.: Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomised controlled trials. (24178062)
2014
8
Dynamic stabilisation in the treatment of degenerative disc disease with modic changes. (23781343)
2013
9
Motion characteristics of the lumbar spinous processes with degenerative disc disease and degenerative spondylolisthesis. (23903997)
2013
10
Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease. (23951558)
2013
11
The fuzzy logic of degenerative disc disease: from a Lorenz attractor to a percolation threshold model. (23689128)
2013
12
Instrumented Posterior Lumbar Interbody Fusion (PLIF) with Interbody Fusion Device (Cage) in Degenerative Disc Disease (DDD): 3 Years Outcome. (24292314)
2013
13
Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. (24010901)
2013
14
The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. (24003854)
2013
15
Differences between arthroplasty and anterior cervical fusion in two-level cervical degenerative disc disease. (24318106)
2013
16
Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease. (23622053)
2013
17
Arthroplasty versus fusion in single-level cervical degenerative disc disease. (22972137)
2012
18
Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients. (21948754)
2011
19
Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study. (21311928)
2011
20
Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. (21249667)
2011
21
How does lumbar degenerative disc disease affect the disc deformation at the cephalic levels in vivo? (21245781)
2011
22
Anterior discectomies and interbody cage fusion without plate fixation for 5-level cervical degenerative disc disease: a 5-year follow-up. (22005163)
2011
23
Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. (20091597)
2010
24
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies. (24198557)
2010
25
Segment-by-segment stabilization for degenerative disc disease: a hybrid technique. (20130934)
2010
26
Efficacy of post-operative analgesia after posterior lumbar instrumented fusion for degenerative disc disease: a prospective randomized comparison of epidural catheter and intravenous administration of analgesics. (21808704)
2010
27
Lateral lumbar interbody fusion via a unilateral true percutaneous approach associated with minimally invasive pedicle screw fixation for degenerative disc disease and lumbar instability. A technical note. (21313957)
2010
28
Influence of single-level lumbar degenerative disc disease on the behavior of the adjacent segments--a finite element model study. (19136113)
2009
29
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (19824220)
2009
30
Follow-up study on the motion range after treatment of degenerative disc disease with the Bryan cervical disc prosthesis. (17497290)
2007
31
Re: Zigler J, Delamarter R, Spivak J, et al. Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. Spine 2007;32:1155-62. (18246024)
2007
32
Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. (17088711)
2006
33
Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs. (16189714)
2006
34
Intradiscal thermal annuloplasty for the treatment of lumbar discogenic pain in patients with multilevel degenerative disc disease. (15271727)
2004
35
Gene therapy for degenerative disc disease. (14724681)
2004
36
Management of degenerative disc disease above an L5-S1 segment requiring arthrodesis. (10382258)
1999
37
Uninstrumented posterolateral lumbar fusion for single level isolated disc resorption and/or degenerative disc disease. (10078947)
1999
38
A multi-center prospective study of the CD Spinal System in patients with degenerative disc disease. (9884289)
1998
39
Surgical results after soft system stabilization of the lumbar spine in degenerative disc disease--long-term results. (9755317)
1998
40
Case 19. Presentation. Degenerative disc disease at L 4-5, L5-S1 and metastatic breast cancer at L 3. (9492743)
1998
41
Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. (9020464)
1997
42
The safety and efficacy of the Isola Spinal Implant System for the surgical treatment of degenerative disc disease. A prospective study. (8726203)
1996
43
Orientation of the lumbar facet joints: association with degenerative disc disease. (8613448)
1996
44
The effect of pedicle screw/plate fixation on lumbar/lumbosacral autogenous bone graft fusions in patients with degenerative disc disease. (7701397)
1995
45
Spinal fusion in degenerative disc disease. (8076465)
1994
46
Comparison of MRI and discography in the diagnosis of lumbar degenerative disc disease. (1490039)
1992
47
Computer analysis of spinal segment motion in degenerative disc disease with and without axial loading. (6495026)
1984
48
Autoimmunity in degenerative disc disease of the lumbar spine. (803670)
1975
49
The use of chymopapain in degenerative disc disease: a preliminary report. (5445694)
1970
50
Pain and disability in degenerative disc disease. (5384672)
1969

Variations for Degenerative Disc Disease

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UniProtKB/Swiss-Prot genetic disease variations for Degenerative Disc Disease:

64
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Degenerative Disc Disease

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Expression patterns in normal tissues for genes affiliated with Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Pathways related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9BMP2, GDF5
2
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.4COMT, DCT
39.4ASPN, ACAN, COL9A2, COL9A3
4
Show member pathways
9.3GDF5, BMP2, COL9A2, COL9A3
5
Show member pathways
8.9GDF5, SOX9, BMP2, COL9A2, COL9A3
6
Show member pathways
8.8COL9A3, COL9A2, BMP2, ACAN, ASPN, GDF5

Compounds for genes affiliated with Degenerative Disc Disease

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Compounds related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4410.1BMP2, ACAN
2chitosan4410.1ACAN, BMP2
3alginate449.8BMP2, ACAN, SOX9
4alendronate44 50 1111.7VDR, BMP2
5l-amino acid449.6COMT, GCH1
6vitamin d449.5BMP2, ACAN, VDR
7glycosaminoglycan449.5GDF5, SOX9, ACAN, BMP2
8mptp449.4VDR, COMT, GCH1
9folate449.3GCH1, COMT, VDR
10levodopa44 1110.3GCH1, COMT, DCT
11sb 20358044 6110.2BMP2, ACAN, VDR
12dexamethasone44 50 28 1112.1BMP2, ACAN, SOX9, VDR
13testosterone44 61 24 1111.9COMT, BMP2, SOX9, VDR
14cysteine448.6VDR, GDF5, DCT, BMP2, COMT
15ascorbic acid44 249.5GCH1, COMT, BMP2, ACAN, SOX9, VDR
16retinoic acid44 249.3VDR, DCT, SOX9, ACAN, BMP2, COMT

GO Terms for genes affiliated with Degenerative Disc Disease

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Cellular components related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IXGO:0055949.6COL9A3, COL9A2
2extracellular regionGO:0055769.0COL9A3, COL9A2, BMP2, ACAN, GDF5

Biological processes related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.0BMP2, SOX9
2bone mineralizationGO:03028210.0ASPN, BMP2
3positive regulation of cartilage developmentGO:06103610.0BMP2, SOX9
4growthGO:04000710.0BMP2, GDF5
5positive regulation of chondrocyte differentiationGO:0323329.9SOX9, GDF5
6extracellular matrix disassemblyGO:0226179.8ACAN, COL9A2, COL9A3
7epithelial to mesenchymal transitionGO:0018379.8SOX9, BMP2
8branching involved in ureteric bud morphogenesisGO:0016589.8BMP2, SOX9
9chondrocyte differentiationGO:0020629.8BMP2, GDF5
10response to painGO:0482659.8GCH1, COMT
11negative regulation of epithelial cell proliferationGO:0506809.4SOX9, GDF5
12skeletal system developmentGO:0015019.1VDR, SOX9, ACAN, BMP2, COL9A2
13extracellular matrix organizationGO:0301988.9COL9A3, COL9A2, BMP2, ACAN, SOX9, GDF5

Molecular functions related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.9COL9A3, COL9A2

Products for genes affiliated with Degenerative Disc Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Degenerative Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet