MCID: DGN001
MIFTS: 54

Degenerative Disc Disease malady

Summaries for Degenerative Disc Disease

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to lumbar disc disease and spondylolisthesis. An important gene associated with Degenerative Disc Disease is ASPN (asporin), and among its related pathways are Non-integrin membrane-ECM interactions and Phenylalanine metabolism. The compounds polyglycolic acid and chitosan have been mentioned in the context of this disorder. Affiliated tissues include intervertebral disc, bone marrow and skeletal muscle, and related mouse phenotype nervous system.

Wikipedia:64 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:47 603932

Aliases & Classifications for Degenerative Disc Disease

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

degenerative disc disease 8 10 45 31
lumbar disc degeneration 8 47
degeneration of lumbar intervertebral disc 61
cervical disc degenerative disorder 61
cervical disc degenerative disease 8
intervertebral disc degeneration 61
intervertebral disc disorder 61
vertebral disc disease 8


External Ids:

Disease Ontology8 DOID:90
NCIt40 C27156
SNOMED-CT57 156633005
ICD1025 M51.8

Related Diseases for Degenerative Disc Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Clinical Features for Degenerative Disc Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

603932

Drugs & Therapeutics for Degenerative Disc Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Degenerative Disc Disease

Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Search CenterWatch for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

Sources:
31LifeMap Discovery™, 14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Degenerative Disc Disease:

33
Bone marrow, Skeletal muscle, Breast, B cells

FMA organs/tissues related to Degenerative Disc Disease:

14
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Degenerative Disc Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8ACAN, FTH1, VDR, DCT, BMP2, SOX9

Publications for Degenerative Disc Disease

Sources:
51PubMed
See all sources

Articles related to Degenerative Disc Disease:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse magnetic resonance imaging analysis of 224 patients. (24231779)
2014
2
A preliminary association study of fat mass and obesity associated gene polymorphisms and degenerative disc disease in a Chinese Han population. (24304927)
2014
3
Artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials. (24323061)
2014
4
Dynamic stabilisation in the treatment of degenerative disc disease with modic changes. (23781343)
2013
5
Motion characteristics of the lumbar spinous processes with degenerative disc disease and degenerative spondylolisthesis. (23903997)
2013
6
Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. (24010901)
2013
7
Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials. (23645003)
2013
8
Bisphosphonate therapy for degenerative disc disease? (24051711)
2013
9
Degenerative disc disease: Altered Wnt signalling in intervertebral disc degeneration. (23399689)
2013
10
Transforaminal Lumbar Interbody Fusion in Degenerative Disc Disease and Spondylolisthesis Grade I: Minimally Invasive Versus Open Surgery. (24136060)
2013
11
Tissue-engineered allograft intervertebral disc transplantation for the treatment of degenerative disc disease: experimental study in a beagle model. (22849557)
2013
12
Complications in Anterior Cervical Discectomy and Fusion for cervical degenerative disc disease. (24076214)
2013
13
Lumbar degenerative disc disease: current and future concepts of diagnosis and management. (22567411)
2012
14
Diagnostic testing for degenerative disc disease. (22844603)
2012
15
Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study. (21311928)
2011
16
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (22724162)
2011
17
Optimization of protein crosslinking formulations for the treatment of degenerative disc disease. (20595926)
2011
18
TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. (21445993)
2011
19
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies. (24198557)
2010
20
Segment-by-segment stabilization for degenerative disc disease: a hybrid technique. (20130934)
2010
21
Efficacy of post-operative analgesia after posterior lumbar instrumented fusion for degenerative disc disease: a prospective randomized comparison of epidural catheter and intravenous administration of analgesics. (21808704)
2010
22
Total disc replacement surgery for symptomatic degenerative lumbar disc disease: a systematic review of the literature. (20508954)
2010
23
Looking ahead: what long-term outcomes can we expect from spinal devices for degenerative disc disease. (20370643)
2008
24
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (18411503)
2008
25
Advances in susceptibility genetics of intervertebral degenerative disc disease. (18781226)
2008
26
Adjacent segment degeneration following spinal fusion for degenerative disc disease. (17539759)
2007
27
Controversial topics in surgery: degenerative disc disease: disc replacement. For. (17316511)
2007
28
Juvenile degenerative disc disease: a report of 76 cases identified by magnetic resonance imaging. (17482117)
2007
29
Outcome analyses of interbody titanium cage fusion used in the anterior discectomy for cervical degenerative disc disease. (16021013)
2005
30
Two-level posterior lumbar interbody fusion for degenerative disc disease: improved clinical outcome with restoration of lumbar lordosis. (16291098)
2005
31
Observer variability based on the strength of MR scanners in the assessment of lumbar degenerative disc disease. (15294326)
2004
32
The "tract" of history in the treatment of lumbar degenerative disc disease. (15264785)
2004
33
A new classification system for degenerative disc disease of the lumbar spine based on magnetic resonance imaging, provocative discography, plain radiographs and anatomic considerations. (15541662)
2004
34
Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. (15495130)
2004
35
Posterior lumbar interbody fusion for degenerative disc disease using a minimally invasive B-twin expandable spinal spacer: a multicenter study. (14526194)
2003
36
Summary statement: emerging techniques for treatment of degenerative lumbar disc disease. (12897470)
2003
37
Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. (12698117)
2003
38
Guidelines for the use of discography for the diagnosis of painful degenerative lumbar disc disease. (15916396)
2002
39
Degenerative disc disease treated with combined anterior and posterior arthrodesis and posterior instrumentation. (12163733)
2002
40
Molecular biology of degenerative disc disease. (11063096)
2000
41
Degenerative disc disease and back pain. (10494530)
1999
42
Case 19. Presentation. Degenerative disc disease at L 4-5, L5-S1 and metastatic breast cancer at L 3. (9492743)
1998
43
Spinal motion in lumbar degenerative disc disease. (9853494)
1998
44
Familial predisposition for lumbar degenerative disc disease. A case-control study. (9589542)
1998
45
Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. (9020464)
1997
46
Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain. (8083266)
1994
47
Comparison of MRI and discography in the diagnosis of lumbar degenerative disc disease. (1490039)
1992
48
Clinical efficacy of spinal instrumentation in lumbar degenerative disc disease. (1502650)
1992
49
Computer analysis of spinal segment motion in degenerative disc disease with and without axial loading. (6495026)
1984
50
Proceedings: Intervertebral disc collagen in degenerative disc disease. (1221933)
1975

Genetic Variations for Degenerative Disc Disease

Expression for genes affiliated with Degenerative Disc Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

Sources:
54Reactome, 30KEGG, 52QIAGEN
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Pathways related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ASPN, COL9A3, ACAN
2
Hide members
9.5DCT, COMT
3
Hide members
8.7ACAN, COL9A3, BMP2, ADAMTS3, ASPN

Compounds for genes affiliated with Degenerative Disc Disease

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4510.1BMP2, ACAN
2chitosan4510.0BMP2, ACAN
3alginate4510.0SOX9, BMP2, ACAN
4glycosaminoglycan459.9SOX9, ACAN, BMP2
5l-amino acid459.7GCH1, COMT
6mptp459.6COMT, VDR, GCH1
7levodopa45 1110.4GCH1, COMT, DCT
8carbon459.4FTH1, VDR, COMT
9folate459.1VDR, COMT, GCH1
10testosterone45 60 11 2412.1SOX9, IDE, VDR, BMP2, COMT
11zinc45 249.9DCT, SOX9, IDE, GCH1, FTH1
12oxygen45 249.7BMP2, FTH1, DCT, GCH1, SOX9
13retinoic acid45 249.6ACAN, BMP2, VDR, DCT, SOX9, COMT
14ascorbic acid45 249.6ACAN, FTH1, VDR, BMP2, COMT, GCH1

GO Terms for genes affiliated with Degenerative Disc Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.2ADAMTS3, ASPN, ACAN

Biological processes related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:00320310.0BMP2, SOX9
2epithelial to mesenchymal transitionGO:00183710.0BMP2, SOX9
3positive regulation of cartilage developmentGO:0610369.9BMP2, SOX9
4response to painGO:0482659.4GCH1, COMT
5skeletal system developmentGO:0015019.4ACAN, BMP2, VDR, SOX9
6extracellular matrix organizationGO:0301988.8ADAMTS3, COL9A3, SOX9, BMP2, ACAN

Products for genes affiliated with Degenerative Disc Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Degenerative Disc Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet