MCID: DGN001
MIFTS: 53

Degenerative Disc Disease malady

Category: Bone diseases

Aliases & Classifications for Degenerative Disc Disease

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Aliases & Descriptions for Degenerative Disc Disease:

Name: Degenerative Disc Disease 35 11 50 13
Intervertebral Disc Degeneration 11 68
Degeneration of Lumbar Intervertebral Disc 68
Cervical Disc Degenerative Disorder 68
 
Cervical Disc Degenerative Disease 11
Intervertebral Disc Disorder 68
Lumbar Disc Degeneration 11
Vertebral Disc Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:90
NCIt45 C27156
SNOMED-CT62 156633005
ICD1030 M51.3

Summaries for Degenerative Disc Disease

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Disease Ontology:11 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary: Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to intervertebral disc disease and spondylolisthesis, and has symptoms including sciatica and sciatica. An important gene associated with Degenerative Disc Disease is ACAN (Aggrecan), and among its related pathways are ECM proteoglycans and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include intervertebral disc, bone and eye, and related mouse phenotype limbs/digits/tail.

Wikipedia:71 Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine.... more...

Related Diseases for Degenerative Disc Disease

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Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1intervertebral disc disease31.8ASPN, COL9A3, VDR
2spondylolisthesis29.6ACAN, CALCA, COL9A3, MMP3
3cervicitis10.6
4acromesomelic dysplasia10.5ACAN, ASPN
5capillariasis10.4CALCA, VDR
6brugada syndrome10.4CALCA, VDR
7primrose syndrome10.4ASPN, CALCA
8cataract ataxia deafness10.4CALCA, NPY
9neuropathy, hereditary thermosensitive10.4CALCA, NPY
10opthalmomandibulomelic dysplasia10.3BMP2, VDR
11alobar holoprosencephaly10.3CALCA, NPY
12bacillary angiomatosis10.3CALCA, VDR
13back pain10.3
14angelucci's syndrome10.3CALCA, VDR
15constrictive pericarditis10.3CALCA, NPY
16acquired hyperkeratosis10.3CALCA, VDR
17pneumatosis cystoides intestinalis10.3BMP2, GDF5
18acromesomelic dysplasia, demirhan type10.3BMP2, GDF5
19syphilitic myelopathy10.3BMP2, SOX9
20carcinoma of the vocal tract10.3CALCA, NPY
21short qt syndrome10.2BMP2, GDF5
22mild pre-eclampsia10.2CALCA, VDR
23neurogenic bladder10.2BMP2, CALCA
24meckel's diverticulum10.2CALCA, COMT
25chorioretinitis10.2MMP3, VDR
26basal ganglia cerebrovascular disease10.2CALCA, IVD
27osteonecrosis10.1ACAN, COL9A3
28hemolytic anemia due to glutathione synthetase deficiency10.1ASPN, GDF5, MMP3
29tracheal stenosis10.1CALCA, NPY
30physical disorder10.0BMP2, CALCA, VDR
31bone deterioration disease10.0BMP2, CALCA, VDR
32myofascial pain syndrome10.0BMP2, IVD
33brain stem angioblastoma10.0ACAN, CALCA, MMP3
34bone resorption disease10.0ACAN, BMP2
35radiculopathy9.9
36west syndrome9.9MMP3, NPY
37osteochondrosis9.9ACAN, ASPN, GDF5, MMP3
38osteoarthritis9.9
39breast cancer9.7
40obesity9.7
41arthritis9.7
42scoliosis9.7
43osteomyelitis9.7
44cystitis9.7
45pancreatitis9.7
46thyroiditis9.7
47spondylarthropathy9.7
48metabolic acidosis9.7
49delayed sleep phase syndrome9.5RPS17, SOX9
50systemic mastocytosis9.4BMP2, GDF5, IVD, MMP3

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Symptoms & Phenotypes for Degenerative Disc Disease

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UMLS symptoms related to Degenerative Disc Disease:


sciatica

MGI Mouse Phenotypes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0ASPN, BMP2, GDF5, SOX9, VDR

Drugs & Therapeutics for Degenerative Disc Disease

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Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 195)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Oxycodoneapproved, illicit, investigationalPhase 436476-42-65284603
Synonyms:
(-)-14-Hydroxydihydrocodeinone
(-)-Oxycodone
(5alpha)-14-hydroxy-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one
124-90-3 (hydrochloride)
14-Hydroxydihydrocodeinone
14-hydroxy-3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one
25333-72-6 (Terephthalate)
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5.alpha.-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
76-42-6
AC-16043
AC1Q4DTG
BRN 0043446
C08018
CHEBI:7852
CHEMBL656
CID5284603
Combunox
D05312
DB00497
DEA No. 9143
Dihydro-14-hydroxycodeinone
Dihydrohydroxycodeinone
Dihydrohydroxycondeinone
Dihydrone
Dihydroxycodeinone
Dinarkon
Diphydrone
EINECS 200-960-2
Endine (Australia)
Endocet
Endodan
Endone
Eubine
Eubine [France]
Eucodal
Eucodalum
Eukodal
Eutagen
HSDB 3142
Hydroxycodeinon
LS-92148
MolPort-004-285-989
Morphinan-6-one, 4,5alpha-epoxy-14-hydroxy-3-methoxy-17-methyl- (8CI)
NSC 19043
NSC19043
 
Ossicodone
Ossicodone [DCIT]
Oxanest
Oxicodona
Oxicodona [INN-Spanish]
Oxicon
Oxicone
Oxiconum
Oxikon
OxyFAST
OxyIR
OxyNorm
Oxycodeinon
Oxycodeinone
Oxycodon
Oxycodone
Oxycodone (USAN/INN)
Oxycodone Concentrate
Oxycodone Hcl
Oxycodone Hydrochloride
Oxycodone [USAN:INN:BAN]
Oxycodone hydrochloride
Oxycodonum
Oxycodonum [INN-Latin]
Oxycon
Oxycone
Oxycontin
Oxyfast
Oxynorm
PTI-821
Pancodine
Pancodone retard (United Kingdom)
Percobarb
Percodan
Percolone
Remoxy
Roxicet
Roxicodone
Supendol
Supendol [Canada]
Supeudol
Tecodin
Tekodin
Tekodin (free base)
Thecodine
Thekodin
Theocodin
UNII-CD35PMG570
WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JO1 P1
oxycodone
2
TravoprostapprovedPhase 4130157283-68-65282226
Synonyms:
(((1R)-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-dihydroxy-2-(3-hydroxy-4-(3-trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(+)-Fluprostenol isopropyl ester
(1R-(1alpha(Z),2beta(1E,3R*),3alpha,5alpha))-7-(3,5-Dihydroxy-2-(3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-5-heptenoic acid, 1-methylethyl ester
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3R)-3-hydroxy-4-((alpha,alpha,alpha-trifluoro-m-isopropyl-tolyl)oxy)-1-butenyl)cyclopentyl)-5-heptenoate
157283-68-6
5-Heptenoic acid,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-,1-methylethyl ester,(5Z)
AC-6103
AC1NQZOS
AL-6221
AL6221
C26H35F3O6
CHEBI:746859
CHEMBL1200799
CID5282226
D01964
DB00287
 
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1e,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
LS-173521
S1554_Selleck
Travatan
Travatan (TN)
Travatan Alcon
Travatan Z
Travatan, Travoprost
Travatanz
Travoprost
Travoprost (JAN/USAN/INN)
Travoprost [USAN]
Travoprostum
ZINC04474682
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
3
Meloxicamapproved, vet_approvedPhase 4, Phase 37971125-38-75281106, 54677470
Synonyms:
(3E)-3-[hydroxy-[(5-methyl-1,3-thiazol-2-yl)amino]methylidene]-2-methyl-1,1-dioxo-1
133687-22-6
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methylthiazolyl)-, 1,1-dioxide
4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
4-hydroxy-2-mehtyl-N-(5-mehtyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
71125-38-7
AC-1325
AC1NQY12
AC1Q3XZW
AKOS000279442
Abbott brand of meloxicam
Almirall brand of meloxicam
Apo-meloxicam
Bio-0826
Boehringer Ingelheim brand of meloxicam
C065757
C08169
C14H13N3O4S2
CCRIS 9139
CHEMBL599
CID5281106
Co Meloxicam
D00969
DB00814
Dom-meloxicam
Europharma brand of meloxicam
FT-0082769
Gen-meloxicam
HMS1922D19
HMS2089B18
I06-0490
LS-40538
M1959
Masflex
 
Meloxicam
Meloxicam (JAN/USAN/INN)
Meloxicam [USAN:BAN:INN]
Meloxicamum
Meloxicamum [Latin]
Meloxicamum [latin]
Meloxivet
Metacam
Mobec
Mobic
Mobic (TN)
Mobic, Metacam, Parocin, Meloxicam
Mobicox
MolPort-002-885-839
Movalis
Movatec
Movicox
Méloxicam
Novo-meloxicam
PHL-meloxicam
PMS-meloxicam
Parocin
Promeco brand of meloxicam
Ratio-meloxicam
S1734_Selleck
SPECTRUM1504150
STK620505
Squibb brand of meloxicam
TL8005001
Tenaron
UH-AC 62XX
UHAC-62XX
UNII-VG2QF83CGL
UNII-vg2qf83cgl
Uticox
meloxicam
miloxicam
reumoxicam
4
TimololapprovedPhase 425226839-75-833624, 5478
Synonyms:
(-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole
(2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol
(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
(S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
(S)-timolol
131628-37-0
194288-09-0
26839-75-8
26921-17-5 (maleate (1:1) salt)
AB00513729
AC1L1PYN
AC1Q59QM
Apo-Timol
Apo-Timop
Aquanil
BIDD:GT0073
BPBio1_001008
BRD-K08806317-050-03-6
BSPBio_000916
Betim
Betimol
Betimol (TN)
Blocadren
C07141
C13H24N4O3S
CAS-26921-17-5
CHEBI:9599
CHEMBL499
CID33624
CPD001456519
D08600
DB00373
DB08625
EINECS 248-032-6
HMS2089I11
HSDB 6533
Istalol
L-714,465
LS-122231
Lopac-T-6394
Lopac0_001189
MK-950
NCGC00016038-01
 
NCGC00016038-02
NCGC00016798-01
NCGC00016798-07
NCGC00022033-02
NCGC00022033-04
NCGC00022033-05
Novo-Timol
Nu-Timolol
Oprea1_640981
Optimol
Phoxal-timolol
Prestwick0_000948
Prestwick1_000948
Prestwick2_000948
Prestwick3_000948
Proflax
S(-)-Timolol maleate
S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole
SAM002564238
SPBio_003075
ST072193
TIM
Temserin
Tenopt
Tim-AK
Timacar
Timacor
Timolol
Timolol (INN)
Timolol (TN)
Timolol GFS
Timolol Maleate, (1:1) Salt
Timolol [USAN]
Timolol anhydrous
Timolol maleate
Timololo
Timololum
Timololum [INN-Latin]
Timopic
Timoptic
Timoptic OcuDose
Timoptic in Ocudose
Timoptic-XE
Timoptol
Tocris-0649
UNII-817W3C6175
timolol
5
Morphineapproved, investigationalPhase 496057-27-25288826
Synonyms:
(-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(-)-Heroin hydrochloride
(-)-Morphine
(-)Morphine sulfate
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol
(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol
(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(5α,6α)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol
(5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol
(−)-morphine
17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol
4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol
4-methyl-(13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol
47106-99-0
57-27-2
6211-15-0 (sulfate (2:1) (salt) pentahydrate)
64-31-3
64-31-3 (sulfate (2:1) (salt) anhydrous)
7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol
7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol
8053-16-5
85201-37-2
Apokyn
Astramorph PF
Avinza
BIDD:GT0147
C01516
CCRIS 5762
CHEBI:17303
CHEMBL70
CID5288826
Cube juice
D-(-)-Morphine
DB00295
DEA No. 9300
DepoDur
Depodur
Diacetylmorphine hydrochloride
Diamorphine hydrochloride
Dolcontin
Dreamer
Dulcontin
Duramorph PF
Duromorph
EINECS 200-320-2
Epimorph
HSDB 2134
Hard stuff
Heroin hydrochloride
Heroine hydrochloride
Hocus
 
Infumorph
Kadian
LS-91748
M-Eslon
M.O.S
MOI
MORPHINE SULFATE
MORPHINE, (5A,6A)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINIAN-3,6-DIOL, MORPHIUM, MORPHIA, DOLCONTIN, DUROMORPH, MORPHINA, NEPENTHE
MS Contin
MS/L
MS/S
MSIR
Meconium
MolPort-003-849-273
Morfina
Morfina [Italian]
Morphia
Morphin
Morphin [German]
Morphina
Morphina [Italian]
Morphine Extra-Forte
Morphine Forte
Morphine H.P
Morphine Sulfate
Morphine [BAN]
Morphinism
Morphinum
Morphitec
Morphium
Morpho
Moscontin
Ms Contin
Ms Emma
NSC11441
Nepenthe
O,O'-Diacetylmorphine hydrochloride
OMS Concentrate
Oramorph SR
Ospalivina
RMS
RMS Uniserts
Rescudose
Roxanol
Roxanol 100
Roxanol UD
SDZ 202-250
SDZ202-250
Statex
Statex Drops
Statex SR
UNII-76I7G6D29C
Unkie
l-Morphine
morfina
morphine
nchembio.317-comp1
nchembio.64-comp1
6
Latanoprostapproved, investigationalPhase 4197130209-82-45282380, 5311221
Synonyms:
130209-82-4
AC1NSK8Q
AR-202
Ambap130209-82-4
CHEBI:6384
CHEMBL1051
CID5311221
CPD000466354
Catioprost
D00356
HMS2051H11
HMS2089J17
Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
Jsp001835
L1167_SIGMA
Latanoprost
Latanoprost (JAN/USAN/INN)
Latanoprostum
MLS000759468
MLS001424106
 
MolPort-003-942-862
Nova-21027
PHXA-41
PhXA 41
PhXA34 [as 15(R,S)-isomer]
PhXA41
Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
S1254_Selleck
SAM001246671
SMR000466354
TL8000716
XA-41
XA41
Xalatan
Xalatan (TN)
Xalatan Fixed Flow Device
ZINC12468792
isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
latanoprost
latanoprost free acid
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
7
Bimatoprostapproved, investigationalPhase 4132155206-00-15311027
Synonyms:
(5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1e,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
155206-00-1
15M
267244-98-4
5-Heptenamide,7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ehtyl-,(5Z)
AC1NSJUW
AGN 192024
AGN-192024
Bimataprost [USAN:INN:BAN]
Bimatoprost
Bimatoprost (JAN/USAN/INN)
Bimatoprost [USAN:INN:BAN]
Bimatoprostum
 
CHEBI:39562
CHEBI:51230
CHEMBL1200963
CID5311027
D02724
DB00905
DB06863
I06-1275
I06-1277
LS-181817
Latisse
Lumigan
Lumigan (TN)
NCGC00181745-01
UNII-QXS94885MZ
ZINC04474405
bimatoprostum
8
NorepinephrineapprovedPhase 468351-41-2439260
Synonyms:
(-)-(R)-Norepinephrine
(-)-Arterenol
(-)-Arterenol free base
(-)-NORADRENALINE
(-)-Noradrenaline
(-)-Norepinephrine
(-)-alpha-(Aminomethyl)protocatechuyl alcohol
(R)-(-)-Norepinephrine
(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol
(R)-Noradrenaline
(R)-Norepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI)
4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol
4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
4899-05-2
51-40-1 (l-tartrate (1:1))
51-41-2
66197-73-7
A7257_SIGMA
AC1L96ZT
ALBB-006229
Adrenor
Aktamin
Arterenol
BRN 4231961
BSPBio_002079
C00547
CHEBI:18357
CHEMBL1437
CID439260
D-(-)-Noradrenaline
D00076
D53D5E3A-2360-4CA9-8031-6C2CD4062FD5
DB00368
DivK1c_000230
EINECS 200-096-6
HMS1920B08
HMS2089E18
HMS2091J08
HMS500L12
IDI1_000230
KBio1_000230
KBio2_001489
KBio2_004057
KBio2_006625
KBio3_001579
KBioGR_000635
KBioSS_001489
L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
L-3,4-Dihydroxyphenylethanolamine
L-3,4-dihydroxyphenylethanolamine
L-Arterenol
L-Noradrenaline
L-Norepinephrine
L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol
L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol
L-arterenol
L-noradrenaline
LS-42676
LT03330026
 
LT4
Levarterenol
Levarterenolo
Levarterenolo [DCIT]
Levoarterenol
Levonor
Levonoradrenaline
Levonorepinephrine
Levophed
NCGC00159406-02
NCGC00159406-03
NCGC00159406-04
NCGC00159406-05
NCGC00159406-06
NCGC00159406-07
NCGC00159406-09
NINDS_000230
Nor adrenalin
Nor adrenalin (TN)
Nor-Epirenan
Nor-adrenaline
Noradrenalin
Noradrenalina
Noradrenalina [Italian]
Noradrenaline
Noradrenaline (JP15)
Noradrenalinum
Norartrinal
Noreinefrina
Noreinefrina [INN-Spanish]
Norepinefrina
Norepinephrine
Norepinephrine (INN)
Norepinephrine Noradrenalin
Norepinephrine [INN:JAN]
Norepinephrine l-Tartrate (1:1)
Norepinephrinum
Norepinephrinum [INN-Latin]
Norepirenamine
PDSP1_001111
PDSP2_001095
SGCUT00123
SPBio_001048
SPECTRUM1500436
STK503776
Spectrum2_001064
Spectrum3_000520
Spectrum4_000078
Spectrum5_001068
Spectrum_001009
Sympathin E
UNII-X4W3ENH1CV
bmse000404
l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol
l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol
nchembio.284-comp2
nchembio.64-comp2
nchembio705-1
noradrenaline
norepinefrina
norepinephrine
norepinephrinum
to_000024
9
DopamineapprovedPhase 4375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
10
Maleic acidexperimentalPhase 4293110-16-7444266
Synonyms:
(2Z)-2-Butenedioate
(2Z)-2-Butenedioic acid
(2Z)-Butene-2-dioate
(2Z)-Butene-2-dioic acid
(2Z)-but-2-enedioate
(2Z)-but-2-enedioic acid
(Z)-2-Butenedioate
(Z)-2-Butenedioic acid
(z)-butenedioate
(z)-butenedioic acid
2-Butenedioate
2-Butenedioic acid
Cis-butenedioate
Cis-butenedioic acid
 
H2male
Kyselina maleinova
MAE
Maleate
Maleic acid
Maleic acid [NA2215]
Maleinic acid
Malenic acid
Malezid CM
Scotchbond multipurpose etchant
Toxilic acid
cis-1,2-Ethylenedicarboxylic acid
cis-2-Butenedioate
cis-2-Butenedioic acid
cis-But-2-enedioate
cis-But-2-enedioic acid
11Antirheumatic AgentsPhase 4, Phase 310627
12
s 1 (combination)Phase 4, Phase 3, Phase 1, Phase 2364
Synonyms:
 
Gimeracil / oteracil / tegafur
TS 1
13Cyclooxygenase InhibitorsPhase 4, Phase 32778
14AnalgesicsPhase 4, Phase 311287
15Trace ElementsPhase 4, Phase 2, Phase 15802
16MicronutrientsPhase 4, Phase 2, Phase 15802
17Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 1, Phase 222776
18Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 34295
19Analgesics, Non-NarcoticPhase 4, Phase 36260
20Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 210355
21AnestheticsPhase 4, Phase 3, Phase 2, Phase 1, Early Phase 19001
22Neurotransmitter AgentsPhase 417734
23Luteolytic AgentsPhase 4294
24TetrahydrozolinePhase 4593
25Lubricant Eye DropsPhase 4162
26Plasma SubstitutesPhase 4233
27Ophthalmic SolutionsPhase 41092
28DextransPhase 499
29Adrenergic AgentsPhase 45140
30Anesthetics, LocalPhase 4, Phase 3, Phase 1, Phase 2, Early Phase 13272
31Central Nervous System DepressantsPhase 4, Phase 3, Phase 1, Phase 212806
32Analgesics, OpioidPhase 4, Phase 33091
33NarcoticsPhase 4, Phase 33486
34Adrenergic AntagonistsPhase 41535
35Adrenergic beta-AntagonistsPhase 41154
36CloprostenolPhase 416
37Contraceptive AgentsPhase 41901
38Antihypertensive AgentsPhase 44095
39Blood SubstitutesPhase 4246
40Anti-Arrhythmia AgentsPhase 4, Phase 3, Phase 22969
41AnticoagulantsPhase 4, Phase 12516
42Serotonin and Noradrenaline Reuptake InhibitorsPhase 4450
43
SiliconPhase 4947440-21-34082203
Synonyms:
Si
 
Silica
Silicate
Silicic acid
44
SerotoninPhase 4356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
45Dopamine AgentsPhase 43759
46Antidepressive AgentsPhase 42666
47Psychotropic DrugsPhase 46279
48Duloxetine HydrochloridePhase 4264
49Neurotransmitter Uptake InhibitorsPhase 43464
50
Hyaluronic acidapproved, vet_approvedPhase 3, Phase 2, Phase 14399004-61-953477741, 24759
Synonyms:
Hyaluronan
Hyaluronate
Hyaluronic acid
Hylartil
Hyruan Plus
Luronit
 
Macronan
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sofast
Synvisc

Interventional clinical trials:

(show top 50)    (show all 329)
idNameStatusNCT IDPhase
1Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc DiseaseCompletedNCT00165893Phase 4
2CHARITE™ vs. ALIF 5-Year Follow-upCompletedNCT00215332Phase 4
3Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™CompletedNCT01615328Phase 4
4Performance of Inductigraft in Spinal FusionCompletedNCT01452022Phase 4
5Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back PainCompletedNCT00443781Phase 4
6Opioid Treatment for Chronic Low Back Pain and the Impact of Mood SymptomsCompletedNCT01502644Phase 4
7Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar PainCompletedNCT01407913Phase 4
8Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal StenosisCompletedNCT00000409Phase 4
9Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc HerniationCompletedNCT00000410Phase 4
10Spine Research With Roentgen Stereophotogrammetric AnalysisCompletedNCT00493558Phase 4
11Spine Patient Outcomes Research Trial (SPORT): Spinal StenosisCompletedNCT00000411Phase 4
12Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent LevelCompletedNCT00554528Phase 4
13The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-studyCompletedNCT02895555Phase 4
14Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAGCompletedNCT01978015Phase 4
15Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical ApproachRecruitingNCT02075554Phase 4
16Comparison of nanOss Cervical IBF System to C-Plus PEEK IBF Device With AutograftRecruitingNCT02586116Phase 4
17Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal StenosisRecruitingNCT01455805Phase 4
18Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody FusionRecruitingNCT02628210Phase 4
19Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody FusionRecruitingNCT01549366Phase 4
20A Prospective Study of the InterFuse T(tm),RecruitingNCT02678130Phase 4
21Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative SpondylolisthesisRecruitingNCT01921530Phase 4
22Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine SurgeryActive, not recruitingNCT02535000Phase 4
23Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF)Active, not recruitingNCT01016314Phase 4
24Post-Market Surveillance Study of the TM Ardis Interbody Fusion SystemActive, not recruitingNCT02429908Phase 4
25Valeo OL Interbody Fusion Devices for Posterior Lumbar Interbody Fusion SNAP TrialActive, not recruitingNCT01557829Phase 4
26Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)Active, not recruitingNCT02182843Phase 4
27Comparison of Complication Rates Between Lateral Approaches to the Lumbar SpineEnrolling by invitationNCT02068729Phase 4
28Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™Not yet recruitingNCT02425514Phase 4
29Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc DiseaseTerminatedNCT00700739Phase 4
30CARES Lumbar Artificial Disc RegistryTerminatedNCT02139527Phase 4
31Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion DeviceTerminatedNCT00095095Phase 4
32Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous ImplantTerminatedNCT01057641Phase 4
33Wallis Stabilization System for Low Back PainUnknown statusNCT00484458Phase 3
34Wallis Mechanical Normalization System for Low Back PainUnknown statusNCT00134537Phase 3
35XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD)CompletedNCT00927238Phase 3
36CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc DiseaseCompletedNCT00215306Phase 3
37rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal StudyCompletedNCT00707265Phase 3
38Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc DiseaseCompletedNCT00316121Phase 3
39Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.CompletedNCT00215319Phase 3
40Cervical I/F Cage for Anterior Cervical FusionCompletedNCT00215293Phase 3
41MAVERICK™ Total Disc Replacement- Pivotal StudyCompletedNCT00635843Phase 3
42Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDDCompletedNCT00667459Phase 3
43LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDECompletedNCT00389597Phase 3
44Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective StudyCompletedNCT01824108Phase 3
45Performance of the Hedrocel(R) Cervical Fusion DeviceCompletedNCT00758758Phase 3
46NORSPAN Transdermal Patches Phase III Study In Non-Cancer PainCompletedNCT01476774Phase 3
47Neurosurgery Patient Outcomes in Treating Spinal DisordersCompletedNCT01220921Phase 3
48Post-Approval Clinical Trial of the PCM® Cervical DiscCompletedNCT01905930Phase 3
49PCM Cervical Disc SystemCompletedNCT00578812Phase 3
50Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or LaminotomyCompletedNCT00939406Phase 2, Phase 3

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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MalaCards organs/tissues related to Degenerative Disc Disease:

36
Bone, Eye, Bone marrow, Spinal cord, Endothelial, Testes, Breast

FMA organs/tissues related to Degenerative Disc Disease:

17
Intervertebral disc

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageAnnulus FibrosusIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageNucleus PulposusIntervertebral Disc Nucleus Pulposus Cells Affected by disease
3 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

About this section

Articles related to Degenerative Disc Disease:

(show top 50)    (show all 304)
idTitleAuthorsYear
1
The usefulness of radiological grading scales to predict pain intensity, functional impairment, and health-related quality of life after surgery for lumbar degenerative disc disease. (27873048)
2017
2
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. (28086781)
2017
3
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. (27902945)
2017
4
Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease. (28002363)
2017
5
Assessment of the Minimum Clinically Important Difference in the Timed Up and Go Test After Surgery for Lumbar Degenerative Disc Disease. (27352275)
2016
6
Association between nutritional status and Modic classification in degenerative disc disease. (27190462)
2016
7
Current and future perspectives on lumbar degenerative disc disease: a UK survey exploring specialist multidisciplinary clinical opinion. (27633633)
2016
8
Intervertebral Fusion with Mobile Microendoscopic Discectomy for Lumbar Degenerative Disc Disease. (27384734)
2016
9
Correlation of pain, functional impairment, and health-related quality of life with radiological grading scales of lumbar degenerative disc disease. (26783024)
2016
10
The 'Lumbar Fusion Outcome Score' (LUFOS): a new practical and surgically oriented grading system for preoperative prediction of surgical outcomes after lumbar spinal fusion in patients with degenerative disc disease and refractory chronicA axial low back pain. (27289367)
2016
11
PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. (26901836)
2016
12
Etiology for Degenerative Disc Disease. (27733227)
2016
13
Comparison of anterior cervical discectomy and fusion with the zero-profile device versus plate and cage in treating cervical degenerative disc disease: A meta-analysis. (27443497)
2016
14
Biological Treatment Approaches for Degenerative Disc Disease: A Review of Clinical Trials and Future Directions. (28018762)
2016
15
Evaluation of Aesculap Implant Systems activl Artificial Disc for the treatment of degenerative disc disease. (27807981)
2016
16
Sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease. (26761383)
2016
17
Patients' Preference of the Timed Up and Go (TUG) Test or Patient-Reported Outcome Measures (PROMs) Before and After Surgery for Lumbar Degenerative Disc Disease. (27913260)
2016
18
A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolutiona8c) with a comparison to historical controls. (26849141)
2016
19
Biochemical validity of imaging techniques (X-ray, MRI, and dGEMRIC) in degenerative disc disease of the human cervical spine-an in vivo study. (27568543)
2016
20
Clinical and radiologic comparison of dynamic cervical implant arthroplasty and cervical total disc replacement for single-level cervical degenerative disc disease. (26928156)
2016
21
Sagittal balance parameters correlate with spinal conformational type and MRI changes in lumbar degenerative disc disease: results of a retrospective study. (27562589)
2016
22
Effects of Smoking on Subjective and Objective Measures of Pain Intensity, Functional Impairment and Health-related Quality of Life in Lumbar Degenerative Disc Disease. (27888086)
2016
23
Reply: the letter to the editor of Dr. Yan Hu entitled "Re: Gao F, Mao T, Sun W, Guo W, Wang Y, Li Z et al. An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD). Spine (Phila Pa 1976) 2015;40(23): 1816-23. (27054456)
2016
24
Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. (27163101)
2016
25
Cost Utility Analysis of the Cervical Artificial Disc vs Fusion for the Treatment of 2-Level Symptomatic Degenerative Disc Disease: 5-Year Follow-up. (26855020)
2016
26
Association of spinal degenerative disc disease with thyroid autoimmunity. (26885680)
2016
27
Return to Work Rates After Single-level Cervical Fusion for Degenerative Disc Disease Compared With Fusion for Radiculopathy in a Workers' Compensation Setting. (27398795)
2016
28
Influence of Body Mass Index on Subjective and Objective Measures of Pain, Functional Impairment, and Health-Related Quality of Life in Lumbar Degenerative Disc Disease. (27686509)
2016
29
Operative Management of Lumbar Degenerative Disc Disease. (27559465)
2016
30
Influence of the mental health status on a new measure of objective functional impairment in lumbar degenerative disc disease. (27988343)
2016
31
Pre- and postoperative correlation of patient-reported outcome measures with standardized Timed Up and Go (TUG) test results in lumbar degenerative disc disease. (27488842)
2016
32
A Pilot Study Of Sequence Of Segmental Contributions In The Lower Cervical Spine During Active Extension And Flexion: Healthy Controls vs. Cervical Degenerative Disc Disease Patients. (27879563)
2016
33
Electromagnetic fields in the treatment of chronic lower back pain in patients with degenerative disc disease. (28031951)
2016
34
MRI Phenotyping of COL9A2/Trp2 and COL9A3/Trp3 Alleles in Degenerative Disc Disease: a Case-Control Study in Southwestern Iranian Population Reveals a Significant Trp3-Disease Association in Males. (27054457)
2016
35
Sex differences in lumbar degenerative disc disease. (27086119)
2016
36
Diagnosing Discogenic Low Back Pain Associated with Degenerative Disc Disease Using a Medical Interview. (27820861)
2016
37
Erratum: Replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. (27058502)
2016
38
In vivo Characteristics of Non-degenerated Adjacent Segment Intervertebral Foramina in Patients with Degenerative Disc Disease during Flexion-Extension. (27379419)
2016
39
Women do not fare worse than men after lumbar fusion surgery: Two-year follow-up results from 4,780 prospectively collected patients in the Swedish National Spine Register with lumbar degenerative disc disease and chronic low back pain. (27845232)
2016
40
Reply to the Letter to the Editor regarding: "An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD)." Spine (Philaa88Pa 1976). 2015 Dec;40(23): 1816-23. (26909830)
2016
41
A systematic review and meta-analysis of outcomes in hybrid constructs for multi-level lumbar degenerative disc disease. (27475322)
2016
42
Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. (27015130)
2016
43
Influence of age on pain intensity, functional impairment and health-related quality of life before and after surgery for lumbar degenerative disc disease. (27579779)
2016
44
Disc nucleus fortification for lumbar degenerative disc disease: a biomechanical study. (26771371)
2016
45
Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses. (27448810)
2016
46
Association of rs731236 polymorphism in the vitamin D receptor gene with degenerative disc disease: evidence from a meta-analysis. (26309717)
2015
47
An 11-year minimum follow-up of the Charite III lumbar disc replacement for the treatment of symptomatic degenerative disc disease. (25895882)
2015
48
Morphological Changes in Degenerative Disc Disease on Magnetic Resonance Imaging: Comparison Between Young and Elderly. (27005714)
2015
49
Clinical and radiological features of hybrid surgery in multilevel cervical degenerative disc disease. (26463866)
2015
50
Association of rs2228570 polymorphism of vitamin D receptor gene with degenerative disc disease: a meta-analysis involving 2947 subjects. (26885185)
2015

Variations for Degenerative Disc Disease

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Expression for genes affiliated with Degenerative Disc Disease

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Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ACAN, ASPN, COL9A3
29.4ACAN, BMP2, GDF5, SOX9
39.3CALCA, NPY
4
Show member pathways
8.5ACAN, ASPN, BMP2, COL9A3, GDF5, MMP3

GO Terms for genes affiliated with Degenerative Disc Disease

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Cellular components related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1ACAN, ASPN, COL9A3, MMP3
2extracellular regionGO:00055768.3ACAN, BMP2, CALCA, COL9A3, GDF5, MMP3

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1chondrocyte developmentGO:000206310.6ACAN, SOX9
2negative regulation of chondrocyte differentiationGO:003233110.5GDF5, SOX9
3negative regulation of mesenchymal cell apoptotic processGO:200105410.5GDF5, SOX9
4endocardial cushion morphogenesisGO:000320310.5BMP2, SOX9
5epithelial to mesenchymal transitionGO:000183710.5BMP2, SOX9
6positive regulation of chondrocyte differentiationGO:003233210.5GDF5, SOX9
7growthGO:004000710.5BMP2, GDF5
8positive regulation of cartilage developmentGO:006103610.5BMP2, SOX9
9bone mineralizationGO:003028210.5ASPN, BMP2
10chondrocyte differentiationGO:000206210.2BMP2, GDF5, SOX9
11negative regulation of ossificationGO:003027910.2CALCA, SOX9
12positive regulation of ossificationGO:004577810.1BMP2, CALCA
13negative regulation of blood pressureGO:004577610.0CALCA, GCH1
14skeletal system developmentGO:00015019.7ACAN, BMP2, SOX9, VDR
15response to painGO:00482659.6CALCA, COMT, GCH1
16vasodilationGO:00423119.4CALCA, GCH1

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051028.7BMP2, CALCA, GDF5, NPY

Sources for Degenerative Disc Disease

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2CDC
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10DGIdb
15ExPASy
16FDA
17FMA
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