Aliases & Classifications for Degenerative Disc Disease

MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 37 12 51 14
Intervertebral Disc Degeneration 12 69
Degeneration of Lumbar Intervertebral Disc 69
Cervical Disc Degenerative Disorder 69
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 69
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 46 C27156
SNOMED-CT 64 156633005
ICD10 32 M51.3

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to intervertebral disc disease and back pain, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is ACAN (Aggrecan), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Morphine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are Increased shRNA abundance and limbs/digits/tail

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 intervertebral disc disease 31.6 ACAN ASPN COL9A3 VDR
2 back pain 30.8 ASPN COL9A3
3 osteoarthritis 29.6 ACAN ASPN GDF5 MMP3 SOX9
4 spondylolisthesis 29.0 BMP2 GDF5 IVD MMP3
5 cervicitis 10.7
6 episodic pain syndrome, familial, 1 10.6
7 oculogyric crisis 10.2 COMT GCH1
8 hypercalcemia, infantile, 1 10.2 CALCA VDR
9 leprosy 2 10.2 CALCA NPY
10 hypochondrogenesis 10.1 ACAN ASPN
11 reflex sympathetic dystrophy 10.1 CALCA NPY
12 epispadias 10.1 CALCA NPY
13 radiculopathy 10.1
14 hypocalcemia, autosomal dominant 1 10.1 CALCA VDR
15 body mass index quantitative trait locus 11 10.0
16 body mass index quantitative trait locus 9 10.0
17 body mass index quantitative trait locus 8 10.0
18 osteoarthritis with mild chondrodysplasia 10.0
19 body mass index quantitative trait locus 4 10.0
20 body mass index quantitative trait locus 10 10.0
21 body mass index quantitative trait locus 7 10.0
22 body mass index quantitative trait locus 12 10.0
23 body mass index quantitative trait locus 14 10.0
24 body mass index quantitative trait locus 18 10.0
25 brachydactyly, type a2 10.0 BMP2 GDF5
26 synovial chondromatosis 10.0 BMP2 SOX9
27 tympanosclerosis 10.0 BMP2 CALCA
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
29 arthritis 9.9
30 osteochondritis dissecans 9.9 ACAN COL9A3 MMP3
31 discitis 9.8 CALCA IVD
32 bone resorption disease 9.8 BMP2 CALCA VDR
33 bone remodeling disease 9.8 BMP2 CALCA VDR
34 blood group, i system 9.8
35 carney complex, type 1 9.8
36 hypoascorbemia 9.8
37 aging 9.8
38 body mass index quantitative trait locus 1 9.8
39 anxiety 9.8
40 scoliosis 9.8
41 osteomyelitis 9.8
42 cystitis 9.8
43 pancreatitis 9.8
44 thyroiditis 9.8
45 spondylarthropathy 9.8
46 ring chromosome y syndrome 9.8
47 carcinoid syndrome 9.7 CALCA NPY
48 polyradiculopathy 9.6 ACAN BMP2 IVD
49 spinal stenosis 9.6 ACAN CALCA COL9A3 MMP3
50 bone deterioration disease 8.4 ACAN BMP2 COL9A3 GDF5 IVD MMP3

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

GenomeRNAi Phenotypes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CA12 CALCA HIF1A MMP3

MGI Mouse Phenotypes related to Degenerative Disc Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 ASPN BMP2 GDF5 HIF1A SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Menthol Approved Phase 4 2216-51-5 16666
8
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2
9 Analgesics Phase 4,Phase 3
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
12 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
13 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
14 Analgesics, Opioid Phase 4,Phase 3
15 Narcotics Phase 4,Phase 3
16
Serotonin Phase 4 50-67-9 5202
17 Neurotransmitter Agents Phase 4
18 Psychotropic Drugs Phase 4
19 Diuretics, Potassium Sparing Phase 4,Phase 3
20 Hormone Antagonists Phase 4,Phase 3
21 Hormones Phase 4,Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
23 Antidepressive Agents Phase 4
24 Dopamine Agents Phase 4
25 Duloxetine Hydrochloride Phase 4
26 Neurotransmitter Uptake Inhibitors Phase 4
27 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
28 diuretics Phase 4
29 Mineralocorticoid Receptor Antagonists Phase 4
30 Mineralocorticoids Phase 4
31 Natriuretic Agents Phase 4
32
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
33
Benzocaine Approved, Investigational Phase 3,Phase 1 1994-09-7, 94-09-7 2337
34
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 644073 40400
35
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
36
Lidocaine Approved, Vet_approved Phase 3,Early Phase 1 137-58-6 3676
37
Methylprednisolone Approved, Vet_approved Phase 3,Early Phase 1 83-43-2 6741
38
Prednisolone Approved, Vet_approved Phase 3,Early Phase 1 50-24-8 5755
39 tannic acid Approved, Nutraceutical Phase 3,Phase 1
40 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
41 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Early Phase 1
42 Protective Agents Phase 3,Phase 2,Phase 1
43 Viscosupplements Phase 3,Phase 2,Phase 1
44 Anti-Inflammatory Agents Phase 3
45 Calcium, Dietary Phase 3,Phase 1,Phase 2
46 Narcotic Antagonists Phase 3
47 Mitogens Phase 2, Phase 3,Phase 1
48 Fibrin Tissue Adhesive Phase 3
49 Anti-Arrhythmia Agents Phase 3
50 Antiemetics Phase 3

Interventional clinical trials:

(show top 50) (show all 297)

# Name Status NCT ID Phase Drugs
1 Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) Unknown status NCT01016314 Phase 4
2 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
3 Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion Unknown status NCT01549366 Phase 4
4 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
5 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Unknown status NCT02182843 Phase 4
6 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
7 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
8 CHARITE™ vs. ALIF 5-Year Follow-up Completed NCT00215332 Phase 4
9 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
10 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
11 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
12 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
13 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
14 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
15 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
16 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Active, not recruiting NCT02535000 Phase 4 Duloxetine;Placebo
17 Eplerenone as a Supplement to Epidural Steroid Injections Not yet recruiting NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
18 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
19 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
20 CARES Lumbar Artificial Disc Registry Terminated NCT02139527 Phase 4
21 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease Unknown status NCT00589797 Phase 3
22 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
23 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
24 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
25 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
26 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
27 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
28 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
29 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
30 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
31 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
32 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
33 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
34 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
35 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
36 Evaluation of Outcomes With Amniotic Fluid for Musculoskeletal Conditions Musculoskeletal Conditions Recruiting NCT03390920 Phase 2, Phase 3
37 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Recruiting NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
38 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
39 Restore CLINICAL TRIAL Active, not recruiting NCT01609374 Phase 3
40 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT02421601 Phase 3 Condoliase
41 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT01941563 Phase 3 Condoliase;placebo
42 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Not yet recruiting NCT03327272 Phase 3 Methylprednisolone;Saline
43 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
44 Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration Unknown status NCT01643681 Phase 1, Phase 2
45 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
46 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
47 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate
48 Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
49 Clinical Trial of YH14618 in Patients With Degenerative Disc Disease Completed NCT02320019 Phase 2 Placebo;YH14618
50 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed NCT01860417 Phase 1, Phase 2 Mepivacaine

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Degenerative Disc Disease:

18
Intervertebral Disc

MalaCards organs/tissues related to Degenerative Disc Disease:

38
Bone, Bone Marrow, Testes, Spinal Cord, Thyroid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 336)
# Title Authors Year
1
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease. ( 29352928 )
2018
2
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
3
Comparison among perfect-CAr, zero-PAr, and plates with a cage in single-level cervical degenerative disc disease. ( 29368613 )
2018
4
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
5
Comparison of dynamic cervical implant versus anterior cervical discectomy and fusion for the treatment of single-level cervical degenerative disc disease: A five-year follow-up. ( 29220729 )
2018
6
Clinical and radiological features of Three Reconstructive Procedures for the Surgical Management of Patients with Bi-level Cervical Degenerative Disc Disease at a Minimum Follow Up Period of Five Years: A Comparative Study. ( 29408574 )
2018
7
Review of long-term outcomes of disc arthroplasty for symptomatic single level cervical degenerative disc disease. ( 29378457 )
2018
8
An intervertebral disc whole organ culture system to investigate proinflammatory and degenerative disc disease condition. ( 29320615 )
2018
9
Degenerative disc disease: Circular RNA reduces cell death in IVD disease. ( 29416131 )
2018
10
Objective Functional Testing in Patients With Lumbar Degenerative Disc Disease. ( 28815166 )
2017
11
Anxiety and depression affect pain drawings in cervical degenerative disc disease. ( 28503982 )
2017
12
Efficacy and safety of Mobi-C cervical artificial disc versus anterior discectomy and fusion in patients with symptomatic degenerative disc disease: A meta-analysis. ( 29245217 )
2017
13
The Concurrent Use of Lumbar Total Disc Arthroplasty and Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure for the Treatment of Multi-Level Symptomatic Degenerative Disc Disease- A Prospective Study. ( 28598895 )
2017
14
The usefulness of radiological grading scales to predict pain intensity, functional impairment, and health-related quality of life after surgery for lumbar degenerative disc disease. ( 27873048 )
2017
15
Hybrid Bone Single Photon Emission Computed Tomography Imaging in Evaluation of Chronic Low Back Pain: Correlation with Modic Changes and Degenerative Disc Disease. ( 28377243 )
2017
16
Comparison of lumbar pedicular dynamic stabilisation systems versus fusion for the treatment of lumbar degenerative disc disease: A meta-analysis. ( 29322911 )
2017
17
Kinematic characteristics of lumbar spinous processes during axial rotation in patients with lumbar degenerative disc disease lateral lumbar interbody fusion and intervention. ( 28376780 )
2017
18
Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. ( 28938891 )
2017
19
Pain drawings predict outcome of surgical treatment for degenerative disc disease in the cervical spine. ( 28718697 )
2017
20
The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine. ( 28670401 )
2017
21
Trends analysis of surgical procedures for cervical degenerative disc disease and myelopathy in patients with tobacco use disorder. ( 28488093 )
2017
22
Surgical and Functional Outcomes After Multilevel Cervical Fusion for Degenerative Disc Disease Compared With Fusion for Radiculopathy: A Study of Workers' Compensation Population. ( 28441686 )
2017
23
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. ( 28086781 )
2017
24
Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus. ( 28358123 )
2017
25
Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease. ( 28894792 )
2017
26
Chemometric evaluation of concentrations of trace elements in intervertebral disc tissue in patient with degenerative disc disease. ( 29284234 )
2017
27
Identifying subsets of patients with single-level degenerative disc disease for lumbar fusion: the value of prognostic tests in surgical decision making. ( 28890222 )
2017
28
Indirect meta-analysis comparing clinical outcomes of total cervical disc replacements with fusions for cervical degenerative disc disease. ( 28496111 )
2017
29
Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up. ( 28748380 )
2017
30
Atherosclerotic Disease and its Relationship to Lumbar Degenerative Disc Disease, Facet Arthritis and Stenosis with Computed Tomography Angiography. ( 28918116 )
2017
31
Does Obesity Affect Perioperative and Postoperative Morbidity and Complication Rates After Minimal Access Spinal Technologies in Surgery for Lumbar Degenerative Disc Disease. ( 29274450 )
2017
32
Clinical Outcomes of Total Disc Replacement Versus Anterior Lumbar Interbody Fusion for Surgical Treatment of Lumbar Degenerative Disc Disease. ( 28811990 )
2017
33
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. ( 27902945 )
2017
34
A comparison of anterior cervical discectomy and fusion combined with cervical disc arthroplasty and cervical disc arthroplasty for the treatment of skip-level cervical degenerative disc disease: A retrospective study. ( 29019878 )
2017
35
Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease. ( 28002363 )
2017
36
Cervical sagittal alignment after different anterior discectomy procedures for single-level cervical degenerative disc disease: randomized controlled trial. ( 28887690 )
2017
37
Influence of Body Mass Index on Subjective and Objective Measures of Pain, Functional Impairment, and Health-Related Quality of Life in Lumbar Degenerative Disc Disease. ( 27686509 )
2016
38
Erratum: Replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27058502 )
2016
39
Correlation of pain, functional impairment, and health-related quality of life with radiological grading scales of lumbar degenerative disc disease. ( 26783024 )
2016
40
Patients' Preference of the Timed Up and Go (TUG) Test or Patient-Reported Outcome Measures (PROMs) Before and After Surgery for Lumbar Degenerative Disc Disease. ( 27913260 )
2016
41
Operative Management of Lumbar Degenerative Disc Disease. ( 27559465 )
2016
42
Assessment of the Minimum Clinically Important Difference in the Timed Up and Go Test After Surgery for Lumbar Degenerative Disc Disease. ( 27352275 )
2016
43
Evaluation of Aesculap Implant Systems activl Artificial Disc for the treatment of degenerative disc disease. ( 27807981 )
2016
44
Influence of the mental health status on a new measure of objective functional impairment in lumbar degenerative disc disease. ( 27988343 )
2016
45
Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27015130 )
2016
46
A Pilot Study Of Sequence Of Segmental Contributions In The Lower Cervical Spine During Active Extension And Flexion: Healthy Controls vs. Cervical Degenerative Disc Disease Patients. ( 27879563 )
2016
47
Intervertebral Fusion with Mobile Microendoscopic Discectomy for Lumbar Degenerative Disc Disease. ( 27384734 )
2016
48
Sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease. ( 26761383 )
2016
49
Reply: the letter to the editor of Dr. Yan Hu entitled "Re: Gao F, Mao T, Sun W, Guo W, Wang Y, Li Z et al. An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD). Spine (Phila Pa 1976) 2015;40(23): 1816-23." ( 27054456 )
2016
50
PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. ( 26901836 )
2016

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 ACAN ASPN BMP2 COL9A3 GDF5 MMP3
2 11.24 ACAN BMP2 GDF5 SOX9
3 11.09 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Cellular components related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.26 ACAN ASPN COL9A3 MMP3
2 extracellular region GO:0005576 9.23 ACAN ASPN BMP2 CALCA COL9A3 GDF5

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.9 BMP2 CALCA GDF5 NPY
2 positive regulation of gene expression GO:0010628 9.87 BMP2 HIF1A SOX9 VDR
3 skeletal system development GO:0001501 9.67 ACAN BMP2 SOX9 VDR
4 negative regulation of blood pressure GO:0045776 9.61 CALCA GCH1
5 regulation of blood pressure GO:0008217 9.61 CALCA GCH1 NPY
6 vasculature development GO:0001944 9.59 CALCA HIF1A
7 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 BMP2 HIF1A
8 vasodilation GO:0042311 9.58 CALCA GCH1
9 chondrocyte differentiation GO:0002062 9.58 BMP2 GDF5 SOX9
10 positive regulation of chondrocyte differentiation GO:0032332 9.56 GDF5 SOX9
11 negative regulation of chondrocyte differentiation GO:0032331 9.55 GDF5 SOX9
12 positive regulation of nitric-oxide synthase activity GO:0051000 9.54 GCH1 HIF1A
13 chondrocyte development GO:0002063 9.52 ACAN SOX9
14 positive regulation of cartilage development GO:0061036 9.51 BMP2 SOX9
15 epithelial to mesenchymal transition GO:0001837 9.5 BMP2 HIF1A SOX9
16 endocardial cushion morphogenesis GO:0003203 9.49 BMP2 SOX9
17 positive regulation of ossification GO:0045778 9.48 BMP2 CALCA
18 negative regulation of bone mineralization GO:0030502 9.46 HIF1A SOX9
19 negative regulation of ossification GO:0030279 9.43 CALCA HIF1A SOX9
20 response to pain GO:0048265 9.33 CALCA COMT GCH1
21 cartilage development GO:0051216 9.26 BMP2 GDF5 HIF1A SOX9
22 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 GDF5 HIF1A SOX9

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.92 BMP2 CALCA GDF5 NPY

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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