MCID: DGN001
MIFTS: 41

Degenerative Disc Disease malady

Summaries for Degenerative Disc Disease

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Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to cervicitis and spondylosis. An important gene associated with Degenerative Disc Disease is ASPN (asporin). Affiliated tissues include intervertebral disc, bone and testes.

Wikipedia:63 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Description from OMIM:46 603932

Aliases & Classifications for Degenerative Disc Disease

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

degenerative disc disease 8 10 44 30
lumbar disc degeneration 8 46
degeneration of lumbar intervertebral disc 60
cervical disc degenerative disorder 60
cervical disc degenerative disease 8
intervertebral disc degeneration 60
intervertebral disc disorder 60
vertebral disc disease 8


External Ids:

Disease Ontology8 DOID:90
NCIt39 C27156
SNOMED-CT56 156633005
ICD1025 M51.8

Related Diseases for Degenerative Disc Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis10.9
2spondylosis10.5
3osteoporotic fracture10.3
4chronic cervicitis10.3
5collagen disease10.3
6intervertebral disc disease10.3
7spondylolysis10.2
8spondyloepiphyseal dysplasia with congenital joint dislocations10.2
9hyperostosis10.2
10atherosclerosis10.2
11breast disease10.1
12cystitis10.1
13obesity10.1
14osteomyelitis10.1
15pancreatitis10.1
16metabolic acidosis10.1

Graphical network of diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Clinical Features for Degenerative Disc Disease

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46OMIM
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Clinical features from OMIM:

603932

Drugs & Therapeutics for Degenerative Disc Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Degenerative Disc Disease

Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Search CenterWatch for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
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MalaCards organs/tissues related to Degenerative Disc Disease:

32
Bone, Testes, Bone marrow, Breast

FMA organs/tissues related to Degenerative Disc Disease:

14
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

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Publications for Degenerative Disc Disease

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Sources:
50PubMed
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Articles related to Degenerative Disc Disease:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease. (23951558)
2013
2
The fuzzy logic of degenerative disc disease: from a Lorenz attractor to a percolation threshold model. (23689128)
2013
3
Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. (24010901)
2013
4
The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. (24003854)
2013
5
Differences between arthroplasty and anterior cervical fusion in two-level cervical degenerative disc disease. (24318106)
2013
6
Editorial Statement " PERSPECTIVES" on the article: "Operative and Nonoperative Treatment Approaches for Lumbar Degenerative Disc Disease Have Similar Long-Term Clinical Outcomes Among Patients with Positive Discography" (24172047)
2013
7
Operative and Nonoperative Treatment Approaches for Lumbar Degenerative Disc Disease Have Similar Long-Term Clinical Outcomes Among Patients with Positive Discography. (24047821)
2013
8
Clinico-biomechanical issues and dynamic stabilization when considering stem cell treatment for degenerative disc disease. (23325008)
2013
9
Posterior dynamic stabilization for the treatment of patients with lumbar degenerative disc disease: long-term clinical and radiological results. (23546904)
2013
10
Phenotype variations affect genetic association studies of degenerative disc disease: conclusions of analysis of genetic association of 58 single nucleotide polymorphisms with highly specific phenotypes for disc degeneration in 332 subjects. (23792102)
2013
11
Stem cell therapy for degenerative disc disease. (22593830)
2012
12
Hybrid surgery of multilevel cervical degenerative disc disease : review of literature and clinical results. (23323165)
2012
13
Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients. (21948754)
2011
14
How does lumbar degenerative disc disease affect the disc deformation at the cephalic levels in vivo? (21245781)
2011
15
Lumbar facet joint motion in patients with degenerative disc disease at affected and adjacent levels: an in vivo biomechanical study. (21270686)
2011
16
Bioresorbable anterior cervical plate device for multi-level degenerative disc disease: case report with 8-year follow-up. (22000835)
2011
17
Early follow-up outcomes after treatment of degenerative disc disease with the discover cervical disc prosthesis. (21377939)
2011
18
Segment-by-segment stabilization for degenerative disc disease: a hybrid technique. (20130934)
2010
19
Efficacy of post-operative analgesia after posterior lumbar instrumented fusion for degenerative disc disease: a prospective randomized comparison of epidural catheter and intravenous administration of analgesics. (21808704)
2010
20
Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. (20863768)
2010
21
Effect of cage geometry on sagittal alignment after posterior lumbar interbody fusion for degenerative disc disease. (20808001)
2010
22
Degenerative disc disease of the lumbar spine on MRI. (21275125)
2010
23
Influence of single-level lumbar degenerative disc disease on the behavior of the adjacent segments--a finite element model study. (19136113)
2009
24
Bioabsorbable instrumentation for single-level cervical degenerative disc disease: a radiological and clinical outcome study. (19929354)
2009
25
Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. (17495770)
2007
26
Artificial inteverbral disc replacement for lumbar degenerative disc disease: what's the state of the evidence? (18193539)
2007
27
Degenerative disc disease: genotyping, MR imaging and phenotyping. (16738912)
2007
28
Degenerative disc disease of the lumbar spine: a prospective comparison of fast T1-weighted fluid-attenuated inversion recovery and T1-weighted turbo spin echo MR imaging. (16036160)
2005
29
A novel surgical treatment of lumbar disc herniation in patients with long-standing degenerative disc disease. (15945425)
2005
30
A review of spinal fusion for degenerative disc disease: need for alternative treatment approach of disc arthroplasty? (15541663)
2004
31
Intermediate follow-up after treatment of degenerative disc disease with the Bryan Cervical Disc Prosthesis: single-level and bi-level. (14673368)
2003
32
An in vivo model of degenerative disc disease. (12507597)
2003
33
Degenerative disc disease treated with combined anterior and posterior arthrodesis and posterior instrumentation. (12163733)
2002
34
Long-term follow-up of functional outcomes and radiographic changes at adjacent levels following lumbar spine fusion for degenerative disc disease. (11563616)
2001
35
The diagnostic performance of vertebral displacement measurements derived from ultrasonic indentation in an in vivo model of degenerative disc disease. (11426151)
2001
36
Minimally invasive surgery for lumbar degenerative disorders: Part II. Degenerative disc disease and lumbar stenosis. (11140348)
2000
37
A multi-center prospective study of the CD Spinal System in patients with degenerative disc disease. (9884289)
1998
38
Changes in collagen cross-linking in degenerative disc disease and scoliosis. (9854753)
1998
39
Posterior cervical fixation for fracture and degenerative disc disease. (9020210)
1997
40
Familial predisposition for degenerative disc disease. A case-control study. (8817779)
1996
41
Degenerative disc disease. A cause for diagnostic dilemma on In-111 WBC studies in suspected osteomyelitis. (8039309)
1994
42
Degenerative disc disease in the lumbar spine: another cause for focally reduced activity on marrow scintigraphy. (1626292)
1992
43
Magnetic resonance assessment of the postoperative spine. Degenerative disc disease. (1829540)
1991
44
The role and incidence of facet tropism in lumbar spine degenerative disc disease. (1839670)
1991
45
Risk and severity of non-back occupational injuries after lumbar laminectomy for degenerative disc disease. (2035551)
1991
46
The Pennsylvania Plan II: an algorithm for the management of lumbar degenerative disc disease. (2939144)
1985
47
Static and dynamic roentgenology in the diagnosis of degenerative disc disease. (6225814)
1983
48
Static and dynamic roentgenography in the diagnosis of degenerative disc disease: a review and comparative assessment. (7161580)
1982
49
Autoimmunity in degenerative disc disease of the lumbar spine. (803670)
1975
50
Backward displacement of fifth lumbar vertebra in degenerative disc disease; the significance of the difference in anteroposterior diameters of the fifth lumbar and first sacral vertebrae. (20270367)
1947

Genetic Variations for Degenerative Disc Disease

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Degenerative Disc Disease:

62
id Symbol AA change Variation ID SNP ID
1COL9A2p.Gln326TrpVAR_012658

Expression for genes affiliated with Degenerative Disc Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Compounds for genes affiliated with Degenerative Disc Disease

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GO Terms for genes affiliated with Degenerative Disc Disease

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Products for genes affiliated with Degenerative Disc Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Degenerative Disc Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet