MCID: DGN001
MIFTS: 57

Degenerative Disc Disease malady

Bone diseases category

Summaries for Degenerative Disc Disease

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Disease Ontology:10 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary: Degenerative Disc Disease, also known as lumbar disc degeneration, is related to spondylolisthesis and intervertebral disc disease. An important gene associated with Degenerative Disc Disease is BMP2 (bone morphogenetic protein 2), and among its related pathways are Elastic fibre formation and ECM proteoglycans. The compounds polyglycolic acid and chitosan have been mentioned in the context of this disorder. Affiliated tissues include intervertebral disc, bone and breast, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:65 Degeneration of one or more intervertebral disc(s) of the spine, often called \"degenerative disc... more...

Aliases & Classifications for Degenerative Disc Disease

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Degenerative Disc Disease, Aliases & Descriptions:

Name: Degenerative Disc Disease 32 10 12 45
Lumbar Disc Degeneration 10 62
Cervical Disc Degenerative Disorder 62
Cervical Disc Degenerative Disease 10
 
Intervertebral Disc Degeneration 62
Intervertebral Disc Disorder 62
Vertebral Disc Disease 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology10 DOID:90
SNOMED-CT57 156633005
NCIt40 C27156

Related Diseases for Degenerative Disc Disease

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Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to degenerative disc disease

Symptoms for Degenerative Disc Disease

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Drugs & Therapeutics for Degenerative Disc Disease

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Drug clinical trials:

Search ClinicalTrials for Degenerative Disc Disease

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

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Anatomical Context for Degenerative Disc Disease

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MalaCards organs/tissues related to Degenerative Disc Disease:

33
Bone, Breast, Testes

FMA organs/tissues related to Degenerative Disc Disease:

16
Intervertebral disc

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id TissueAnatomical CompartmentCell Relevance
1 CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
2 CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
3 CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
4 CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells Affected by disease
5 CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
6 CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
7 CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
8 CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells Affected by disease
9 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
10 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Degenerative Disc Disease or affiliated genes

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MGI Mouse Phenotypes related to Degenerative Disc Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0VDR, SOX9, ACAN, BMP2
2MP:00053718.8BMP2, ACAN, SOX9, GDF5, VDR
3MP:00053908.4VDR, GDF5, SOX9, ACAN, BMP2
4MP:00036318.0COMT, BMP2, ACAN, SOX9, DCT, VDR
5MP:00053897.9VDR, GDF5, SOX9, BMP2, COMT, TBPL1

Publications for Degenerative Disc Disease

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Articles related to Degenerative Disc Disease:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Sharp, left-sided back pain A^ bilateral leg weakness A^ degenerative disc disease A^ Dx? (25671528)
2015
2
An 11-year minimum follow-up of the Charite III lumbar disc replacement for the treatment of symptomatic degenerative disc disease. (25895882)
2015
3
End plate disproportion and degenerative disc disease: a case-control study. (25187856)
2014
4
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (24933742)
2014
5
Mesenchymal stem cell technology in the treatment of degenerative disc disease. (25373318)
2014
6
Genetic susceptibility of lumbar degenerative disc disease in young Indian adults. (25416170)
2014
7
Stand-alone anterior lumbar interbody fusion for degenerative disc disease of the lumbar spine: results with a 2-year follow-up. (24825156)
2014
8
Re: Phillips FM, Slosar PJ, Youssef JA, et al. Systematic review of lumbar spine fusion for chronic low back pain due to degenerative disc disease. Spine (Phila Pa 1976) 2013;38:E409a8922. (24525984)
2014
9
Effects of Spinal Stabilization Exercise on the Cross-sectional Areas of the Lumbar Multifidus and Psoas Major Muscles, Pain Intensity, and Lumbar Muscle Strength of Patients with Degenerative Disc Disease. (24764637)
2014
10
Letter regarding article by Wei et al.: Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomised controlled trials. (24178062)
2014
11
Dynamic stabilisation in the treatment of degenerative disc disease with modic changes. (23781343)
2013
12
Motion characteristics of the lumbar spinous processes with degenerative disc disease and degenerative spondylolisthesis. (23903997)
2013
13
Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease. (23951558)
2013
14
The fuzzy logic of degenerative disc disease: from a Lorenz attractor to a percolation threshold model. (23689128)
2013
15
Instrumented Posterior Lumbar Interbody Fusion (PLIF) with Interbody Fusion Device (Cage) in Degenerative Disc Disease (DDD): 3 Years Outcome. (24292314)
2013
16
Cervical total disc replacement with the Mobi-C cervical artificial disc compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled multicenter clinical trial: clinical article. (24010901)
2013
17
The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. (24003854)
2013
18
Differences between arthroplasty and anterior cervical fusion in two-level cervical degenerative disc disease. (24318106)
2013
19
Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease. (23622053)
2013
20
Arthroplasty versus fusion in single-level cervical degenerative disc disease. (22972137)
2012
21
Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients. (21948754)
2011
22
Does anterior lumbar interbody fusion promote adjacent degeneration in degenerative disc disease? A finite element study. (21311928)
2011
23
Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. (21249667)
2011
24
Impact of total disc arthroplasty on the surgical management of lumbar degenerative disc disease: Analysis of the Nationwide Inpatient Sample from 2000 to 2008. (22059134)
2011
25
How does lumbar degenerative disc disease affect the disc deformation at the cephalic levels in vivo? (21245781)
2011
26
Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease. (20091597)
2010
27
Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies. (24198557)
2010
28
Segment-by-segment stabilization for degenerative disc disease: a hybrid technique. (20130934)
2010
29
Efficacy of post-operative analgesia after posterior lumbar instrumented fusion for degenerative disc disease: a prospective randomized comparison of epidural catheter and intravenous administration of analgesics. (21808704)
2010
30
Lateral lumbar interbody fusion via a unilateral true percutaneous approach associated with minimally invasive pedicle screw fixation for degenerative disc disease and lumbar instability. A technical note. (21313957)
2010
31
Influence of single-level lumbar degenerative disc disease on the behavior of the adjacent segments--a finite element model study. (19136113)
2009
32
Artificial intervertebral disc arthroplasty for treatment of degenerative disc disease of the cervical spine. (19824220)
2009
33
Follow-up study on the motion range after treatment of degenerative disc disease with the Bryan cervical disc prosthesis. (17497290)
2007
34
Re: Zigler J, Delamarter R, Spivak J, et al. Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. Spine 2007;32:1155-62. (18246024)
2007
35
Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. (17088711)
2006
36
Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs. (16189714)
2006
37
Intradiscal thermal annuloplasty for the treatment of lumbar discogenic pain in patients with multilevel degenerative disc disease. (15271727)
2004
38
Gene therapy for degenerative disc disease. (14724681)
2004
39
Management of degenerative disc disease above an L5-S1 segment requiring arthrodesis. (10382258)
1999
40
A multi-center prospective study of the CD Spinal System in patients with degenerative disc disease. (9884289)
1998
41
Surgical results after soft system stabilization of the lumbar spine in degenerative disc disease--long-term results. (9755317)
1998
42
Case 19. Presentation. Degenerative disc disease at L 4-5, L5-S1 and metastatic breast cancer at L 3. (9492743)
1998
43
Sensory and sympathetic innervation of the vertebral endplate in patients with degenerative disc disease. (9020464)
1997
44
The safety and efficacy of the Isola Spinal Implant System for the surgical treatment of degenerative disc disease. A prospective study. (8726203)
1996
45
Orientation of the lumbar facet joints: association with degenerative disc disease. (8613448)
1996
46
The effect of pedicle screw/plate fixation on lumbar/lumbosacral autogenous bone graft fusions in patients with degenerative disc disease. (7701397)
1995
47
Comparison of MRI and discography in the diagnosis of lumbar degenerative disc disease. (1490039)
1992
48
Computer analysis of spinal segment motion in degenerative disc disease with and without axial loading. (6495026)
1984
49
Autoimmunity in degenerative disc disease of the lumbar spine. (803670)
1975
50
Pain and disability in degenerative disc disease. (5384672)
1969

Variations for Degenerative Disc Disease

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Expression for genes affiliated with Degenerative Disc Disease

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Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for genes affiliated with Degenerative Disc Disease

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Pathways related to Degenerative Disc Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9BMP2, GDF5
29.6ASPN, ACAN, COL9A3
3
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.4COMT, DCT
4
Show member pathways
9.0COL9A3, BMP2, ACAN, ASPN, GDF5

Compounds for genes affiliated with Degenerative Disc Disease

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Compounds related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1polyglycolic acid4510.2BMP2, ACAN
2chitosan4510.2BMP2, ACAN
3alendronate45 51 1311.9BMP2, VDR
4alginate459.8SOX9, ACAN, BMP2
5l-amino acid459.8COMT, GCH1
6raloxifene45 51 30 1312.7BMP2, VDR
7sb 20358045 6110.5VDR, ACAN, BMP2
8glycosaminoglycan459.5GDF5, SOX9, ACAN, BMP2
9vitamin d459.5BMP2, ACAN, VDR
10mptp459.4GCH1, COMT, VDR
11folate459.4VDR, COMT, GCH1
12levodopa45 1310.3GCH1, COMT, DCT
13dexamethasone45 51 30 1312.2BMP2, ACAN, SOX9, VDR
14testosterone45 61 26 1312.0COMT, BMP2, SOX9, VDR
15estrogen458.9GCH1, COMT, BMP2, VDR
16cysteine458.6VDR, GDF5, DCT, BMP2, COMT
17oxygen45 269.6DCT, SOX9, BMP2, GCH1
18ascorbic acid45 269.5GCH1, COMT, BMP2, ACAN, SOX9, VDR
19retinoic acid45 269.3COMT, BMP2, ACAN, SOX9, DCT, VDR

GO Terms for genes affiliated with Degenerative Disc Disease

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Biological processes related to Degenerative Disc Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion morphogenesisGO:000320310.0BMP2, SOX9
2bone mineralizationGO:003028210.0ASPN, BMP2
3positive regulation of cartilage developmentGO:006103610.0BMP2, SOX9
4growthGO:004000710.0BMP2, GDF5
5positive regulation of chondrocyte differentiationGO:00323329.9SOX9, GDF5
6epithelial to mesenchymal transitionGO:00018379.8SOX9, BMP2
7branching involved in ureteric bud morphogenesisGO:00016589.8BMP2, SOX9
8chondrocyte differentiationGO:00020629.8BMP2, GDF5
9response to painGO:00482659.8COMT, GCH1
10negative regulation of epithelial cell proliferationGO:00506809.4SOX9, GDF5
11skeletal system developmentGO:00015019.3VDR, SOX9, ACAN, BMP2
12extracellular matrix organizationGO:00301989.1COL9A3, BMP2, ACAN, SOX9, GDF5

Products for genes affiliated with Degenerative Disc Disease

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Sources for Degenerative Disc Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet