Aliases & Classifications for Degenerative Disc Disease

MalaCards integrated aliases for Degenerative Disc Disease:

Name: Degenerative Disc Disease 38 12 52 14
Intervertebral Disc Degeneration 12 69
Degeneration of Lumbar Intervertebral Disc 69
Cervical Disc Degenerative Disorder 69
Cervical Disc Degenerative Disease 12
Intervertebral Disc Disorder 69
Lumbar Disc Degeneration 12
Vertebral Disc Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:90
NCIt 47 C27156
SNOMED-CT 64 156633005
ICD10 33 M51.3
UMLS 69 C0410606

Summaries for Degenerative Disc Disease

Disease Ontology : 12 A bone deterioration disease that has material basis in gradual dehydration and tears located in intervertebral disc.

MalaCards based summary : Degenerative Disc Disease, also known as intervertebral disc degeneration, is related to spondylolisthesis and osteochondrosis, and has symptoms including sciatica An important gene associated with Degenerative Disc Disease is ACAN (Aggrecan), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Morphine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Cartilage, and related phenotypes are Increased shRNA abundance and limbs/digits/tail

Wikipedia : 72 Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine.... more...

Related Diseases for Degenerative Disc Disease

Diseases related to Degenerative Disc Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 spondylolisthesis 29.4 ACAN CALCA COL9A3 MMP3
2 osteochondrosis 28.9 ACAN ASPN GDF5 MMP3 SOX9
3 intervertebral disc disease 11.1
4 cervicitis 10.6
5 waardenburg syndrome, type 4b 10.4 CALCA VDR
6 acromesomelic dysplasia 10.3 ACAN ASPN
7 back pain 10.3
8 spasmodic dystonia 10.3 COMT GCH1
9 central cord syndrome 10.3 ASPN COL9A3
10 neuropathy, hereditary thermosensitive 10.2 CALCA NPY
11 x-linked intellectual disability, porteous type 10.2 CALCA NPY
12 amyloidosis, finnish type 10.1 COMT GCH1
13 epileptic encephalopathy, early infantile, 7 10.1 ASPN COL9A3 VDR
14 hemolytic anemia due to glutathione synthetase deficiency 10.1 ASPN GDF5 MMP3
15 low compliance bladder 10.1 BMP2 CALCA
16 acromesomelic dysplasia, demirhan type 10.1 BMP2 GDF5
17 syringobulbia 10.0 BMP2 SOX9
18 radiculopathy 10.0
19 osteoarthritis 9.9
20 epilepsy idiopathic generalized 8 9.9 CALCA VDR
21 osteonecrosis 9.9 ACAN COL9A3 MMP3
22 basal ganglia cerebrovascular disease 9.9 CALCA IVD
23 carcinoma of unknown primary site, childhood 9.9 CALCA NPY
24 physical disorder 9.9 BMP2 CALCA VDR
25 bone deterioration disease 9.9 BMP2 CALCA VDR
26 obesity 9.9
27 arthritis 9.9
28 scoliosis 9.7
29 osteomyelitis 9.7
30 cystitis 9.7
31 pancreatitis 9.7
32 thyroiditis 9.7
33 spondylarthropathy 9.7
34 breast cancer 9.7
35 metabolic acidosis 9.7
36 smooth muscle tumor 9.5 ACAN BMP2 IVD
37 systemic mastocytosis 9.0 BMP2 GDF5 IVD MMP3
38 bone structure disease 8.0 ACAN BMP2 COL9A3 GDF5 IVD MMP3
39 chromosomal disease 8.0 ACAN BMP2 COL9A3 GDF5 IVD MMP3
40 dengue hemorrhagic fever 5.2 ACAN ASPN BMP2 CA12 CALCA COL9A3

Graphical network of the top 20 diseases related to Degenerative Disc Disease:



Diseases related to Degenerative Disc Disease

Symptoms & Phenotypes for Degenerative Disc Disease

UMLS symptoms related to Degenerative Disc Disease:


sciatica

GenomeRNAi Phenotypes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CA12 CALCA HIF1A MMP3

MGI Mouse Phenotypes related to Degenerative Disc Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.1 ASPN BMP2 GDF5 HIF1A SOX9 VDR

Drugs & Therapeutics for Degenerative Disc Disease

Drugs for Degenerative Disc Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
3
Meloxicam Approved, Vet_approved Phase 4,Phase 3 71125-38-7 5281106 54677470
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Norepinephrine Approved Phase 4 51-41-2 439260
6
Menthol Approved Phase 4 2216-51-5 16666
7
s 1 (combination) Phase 4,Phase 3,Phase 1,Phase 2
8 Analgesics Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Analgesics, Non-Narcotic Phase 4,Phase 3
11 Anti-Inflammatory Agents Phase 4,Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
13 Antirheumatic Agents Phase 4,Phase 3
14 Cyclooxygenase Inhibitors Phase 4,Phase 3
15 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
16 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
18 Analgesics, Opioid Phase 4,Phase 3
19 Narcotics Phase 4,Phase 3
20 Neurotransmitter Agents Phase 4
21 Psychotropic Drugs Phase 4
22 Antidepressive Agents Phase 4
23 Dopamine Agents Phase 4
24 Duloxetine Hydrochloride Phase 4
25 Neurotransmitter Uptake Inhibitors Phase 4
26
Serotonin Phase 4 50-67-9 5202
27 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
28
Benzocaine Approved Phase 3,Phase 1 1994-09-7, 94-09-7 2337
29
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
30
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
31
Hyaluronic acid Approved, Vet_approved Phase 3,Phase 2,Phase 1 9004-61-9 53477741 24759
32
Lidocaine Approved, Vet_approved Phase 3,Early Phase 1 137-58-6 3676
33
Methylprednisolone Approved, Vet_approved Phase 3,Early Phase 1 83-43-2 6741
34
Prednisolone Approved, Vet_approved Phase 3,Early Phase 1 50-24-8 5755
35 tannic acid Approved, Nutraceutical Phase 3,Phase 1
36 Calcium, Dietary Phase 3,Phase 1,Phase 2
37 Narcotic Antagonists Phase 3
38 Pharmaceutical Solutions Phase 3,Phase 2,Early Phase 1
39 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
40 Protective Agents Phase 3,Phase 2,Phase 1
41 Viscosupplements Phase 3,Phase 2,Phase 1
42 Coagulants Phase 3,Phase 1
43 Fibrin Tissue Adhesive Phase 3
44 Hemostatics Phase 3,Phase 1
45 Anti-Arrhythmia Agents Phase 3
46 Antiemetics Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Autonomic Agents Phase 3
49 Diuretics, Potassium Sparing Phase 3
50 Gastrointestinal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 288)

id Name Status NCT ID Phase Drugs
1 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
2 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Unknown status NCT02182843 Phase 4
3 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
4 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
5 CHARITE™ vs. ALIF 5-Year Follow-up Completed NCT00215332 Phase 4
6 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
7 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
8 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed NCT01502644 Phase 4 Oxycodone;Morphine;Placebo
9 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
10 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
11 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
12 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
13 Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody Fusion Recruiting NCT01549366 Phase 4
14 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
15 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
16 Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) Active, not recruiting NCT01016314 Phase 4
17 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Active, not recruiting NCT02429908 Phase 4
18 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Active, not recruiting NCT02535000 Phase 4 Duloxetine;Placebo
19 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
20 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
21 CARES Lumbar Artificial Disc Registry Terminated NCT02139527 Phase 4
22 Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease Unknown status NCT00589797 Phase 3
23 Wallis Stabilization System for Low Back Pain Unknown status NCT00484458 Phase 3
24 Wallis Mechanical Normalization System for Low Back Pain Unknown status NCT00134537 Phase 3
25 XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) Completed NCT00927238 Phase 3
26 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
27 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed NCT00316121 Phase 3
28 CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease Completed NCT00215306 Phase 3
29 Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. Completed NCT00215319 Phase 3
30 MAVERICK™ Total Disc Replacement- Pivotal Study Completed NCT00635843 Phase 3
31 Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical DDD Completed NCT00667459 Phase 3
32 LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE Completed NCT00389597 Phase 3
33 Cervical I/F Cage for Anterior Cervical Fusion Completed NCT00215293 Phase 3
34 Wallis Interspinous Dynamic Stability System for Lumbar Disc Herniation: a Prospective Study Completed NCT01824108 Phase 3
35 Performance of the Hedrocel(R) Cervical Fusion Device Completed NCT00758758 Phase 3
36 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
37 Comparative Evaluation of Clinical Outcome of Degenerative Disc Disease Treated With the GelStix GelStix Study Recruiting NCT02763956 Phase 3
38 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
39 Assessment of the Efficacy of an Intradiscal Injection of Corticoids in Modic I Discopathies. Recruiting NCT01694134 Phase 3 Hydrocortancyl.;Lidocaine
40 Study of the Safety and Effectiveness of DIAM™ Spinal Stabilization System Versus Conservative Care Active, not recruiting NCT00456378 Phase 3
41 Prospective Study of Thoracolumbar Spinal Fusion Graft Active, not recruiting NCT02297256 Phase 3
42 Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels Active, not recruiting NCT00637156 Phase 3
43 Restore CLINICAL TRIAL Active, not recruiting NCT01609374 Phase 3
44 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT02421601 Phase 3 Condoliase
45 A Study of SI-6603 in Patients With Lumbar Disc Herniation Active, not recruiting NCT01941563 Phase 3 Condoliase;placebo
46 Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline
47 Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798239 Phase 1, Phase 2
48 Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery Unknown status NCT00798902 Phase 1, Phase 2
49 Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration Unknown status NCT01643681 Phase 1, Phase 2
50 Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease Unknown status NCT01799616 Phase 2 Pamidronate

Search NIH Clinical Center for Degenerative Disc Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Degenerative Disc Disease cell therapies at LifeMap Discovery.

Genetic Tests for Degenerative Disc Disease

Anatomical Context for Degenerative Disc Disease

MalaCards organs/tissues related to Degenerative Disc Disease:

39
Bone, Bone Marrow, Testes, Spinal Cord, Thyroid, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Degenerative Disc Disease:
id Tissue Anatomical CompartmentCell Relevance
1 Cartilage Annulus Fibrosus Intervertebral Disc Annulus Fibrosus Cells Affected by disease
2 Cartilage Nucleus Pulposus Intervertebral Disc Nucleus Pulposus Cells Affected by disease
3 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Degenerative Disc Disease

Articles related to Degenerative Disc Disease:

(show top 50) (show all 321)
id Title Authors Year
1
Trends analysis of surgical procedures for cervical degenerative disc disease and myelopathy in patients with tobacco use disorder. ( 28488093 )
2017
2
Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up. ( 28748380 )
2017
3
The usefulness of radiological grading scales to predict pain intensity, functional impairment, and health-related quality of life after surgery for lumbar degenerative disc disease. ( 27873048 )
2017
4
Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. ( 27902945 )
2017
5
Identifying subsets of patients with single-level degenerative disc disease for lumbar fusion: the value of prognostic tests in surgical decision making. ( 28890222 )
2017
6
The Concurrent Use of Lumbar Total Disc Arthroplasty and Anterior Lumbar Interbody Fusion: The Lumbar Hybrid Procedure for the Treatment of Multi-Level Symptomatic Degenerative Disc Disease- A Prospective Study. ( 28598895 )
2017
7
Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus. ( 28358123 )
2017
8
Hybrid Bone Single Photon Emission Computed Tomography Imaging in Evaluation of Chronic Low Back Pain: Correlation with Modic Changes and Degenerative Disc Disease. ( 28377243 )
2017
9
Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease. ( 28894792 )
2017
10
Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease. ( 28002363 )
2017
11
Pain drawings predict outcome of surgical treatment for degenerative disc disease in the cervical spine. ( 28718697 )
2017
12
Indirect meta-analysis comparing clinical outcomes of total cervical disc replacements with fusions for cervical degenerative disc disease. ( 28496111 )
2017
13
Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. ( 28938891 )
2017
14
Objective Functional Testing in Patients With Lumbar Degenerative Disc Disease. ( 28815166 )
2017
15
Kinematic characteristics of lumbar spinous processes during axial rotation in patients with lumbar degenerative disc disease lateral lumbar interbody fusion and intervention. ( 28376780 )
2017
16
Atherosclerotic Disease and its Relationship to Lumbar Degenerative Disc Disease, Facet Arthritis and Stenosis with Computed Tomography Angiography. ( 28918116 )
2017
17
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. ( 28086781 )
2017
18
The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine. ( 28670401 )
2017
19
Anxiety and depression affect pain drawings in cervical degenerative disc disease. ( 28503982 )
2017
20
Clinical Outcomes of Total Disc Replacement Versus Anterior Lumbar Interbody Fusion for Surgical Treatment of Lumbar Degenerative Disc Disease. ( 28811990 )
2017
21
Cervical sagittal alignment after different anterior discectomy procedures for single-level cervical degenerative disc disease: randomized controlled trial. ( 28887690 )
2017
22
Surgical and Functional Outcomes After Multilevel Cervical Fusion for Degenerative Disc Disease Compared With Fusion for Radiculopathy: A Study of Workers' Compensation Population. ( 28441686 )
2017
23
Clinical and radiologic comparison of dynamic cervical implant arthroplasty and cervical total disc replacement for single-level cervical degenerative disc disease. ( 26928156 )
2016
24
Total disc replacement versus fusion for lumbar degenerative disc disease: a systematic review of overlapping meta-analyses. ( 27448810 )
2016
25
Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27015130 )
2016
26
Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. ( 27163101 )
2016
27
MRI Phenotyping of COL9A2/Trp2 and COL9A3/Trp3 Alleles in Degenerative Disc Disease: a Case-Control Study in Southwestern Iranian Population Reveals a Significant Trp3-Disease Association in Males. ( 27054457 )
2016
28
Sex differences in subjective and objective measures of pain, functional impairment, and health-related quality of life in patients with lumbar degenerative disc disease. ( 26761383 )
2016
29
Biological Treatment Approaches for Degenerative Disc Disease: A Review of Clinical Trials and Future Directions. ( 28018762 )
2016
30
A systematic review and meta-analysis of outcomes in hybrid constructs for multi-level lumbar degenerative disc disease. ( 27475322 )
2016
31
Current and future perspectives on lumbar degenerative disc disease: a UK survey exploring specialist multidisciplinary clinical opinion. ( 27633633 )
2016
32
Influence of age on pain intensity, functional impairment and health-related quality of life before and after surgery for lumbar degenerative disc disease. ( 27579779 )
2016
33
A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolutiona8c) with a comparison to historical controls. ( 26849141 )
2016
34
Sex differences in lumbar degenerative disc disease. ( 27086119 )
2016
35
Reply: the letter to the editor of Dr. Yan Hu entitled "Re: Gao F, Mao T, Sun W, Guo W, Wang Y, Li Z et al. An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD). Spine (Phila Pa 1976) 2015;40(23): 1816-23." ( 27054456 )
2016
36
Pre- and postoperative correlation of patient-reported outcome measures with standardized Timed Up and Go (TUG) test results in lumbar degenerative disc disease. ( 27488842 )
2016
37
Reply to the Letter to the Editor regarding: "An Updated Meta-Analysis Comparing Artificial Cervical Disc Arthroplasty (CDA) Versus Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (CDDD)." Spine (Philaa88Pa 1976). 2015 Dec;40(23): 1816-23. ( 26909830 )
2016
38
Electromagnetic fields in the treatment of chronic lower back pain in patients with degenerative disc disease. ( 28031951 )
2016
39
Comparison of anterior cervical discectomy and fusion with the zero-profile device versus plate and cage in treating cervical degenerative disc disease: A meta-analysis. ( 27443497 )
2016
40
Biochemical validity of imaging techniques (X-ray, MRI, and dGEMRIC) in degenerative disc disease of the human cervical spine-an in vivo study. ( 27568543 )
2016
41
Evaluation of Aesculap Implant Systems activl Artificial Disc for the treatment of degenerative disc disease. ( 27807981 )
2016
42
PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. ( 26901836 )
2016
43
Erratum: Replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial. ( 27058502 )
2016
44
Influence of Body Mass Index on Subjective and Objective Measures of Pain, Functional Impairment, and Health-Related Quality of Life in Lumbar Degenerative Disc Disease. ( 27686509 )
2016
45
Diagnosing Discogenic Low Back Pain Associated with Degenerative Disc Disease Using a Medical Interview. ( 27820861 )
2016
46
Patients' Preference of the Timed Up and Go (TUG) Test or Patient-Reported Outcome Measures (PROMs) Before and After Surgery for Lumbar Degenerative Disc Disease. ( 27913260 )
2016
47
Operative Management of Lumbar Degenerative Disc Disease. ( 27559465 )
2016
48
Intervertebral Fusion with Mobile Microendoscopic Discectomy for Lumbar Degenerative Disc Disease. ( 27384734 )
2016
49
Assessment of the Minimum Clinically Important Difference in the Timed Up and Go Test After Surgery for Lumbar Degenerative Disc Disease. ( 27352275 )
2016
50
Association between nutritional status and Modic classification in degenerative disc disease. ( 27190462 )
2016

Variations for Degenerative Disc Disease

Expression for Degenerative Disc Disease

Search GEO for disease gene expression data for Degenerative Disc Disease.

Pathways for Degenerative Disc Disease

Pathways related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 ACAN ASPN BMP2 COL9A3 GDF5 MMP3
2 11.24 ACAN BMP2 GDF5 SOX9
3 11.09 ACAN ASPN COL9A3

GO Terms for Degenerative Disc Disease

Cellular components related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.26 ACAN ASPN COL9A3 MMP3
2 extracellular region GO:0005576 9.23 ACAN ASPN BMP2 CALCA COL9A3 GDF5

Biological processes related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.87 BMP2 HIF1A SOX9 VDR
2 skeletal system development GO:0001501 9.71 ACAN BMP2 SOX9 VDR
3 regulation of blood pressure GO:0008217 9.61 CALCA GCH1 NPY
4 negative regulation of blood pressure GO:0045776 9.6 CALCA GCH1
5 vasculature development GO:0001944 9.59 CALCA HIF1A
6 vasodilation GO:0042311 9.58 CALCA GCH1
7 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.58 BMP2 HIF1A
8 positive regulation of chondrocyte differentiation GO:0032332 9.56 GDF5 SOX9
9 negative regulation of chondrocyte differentiation GO:0032331 9.55 GDF5 SOX9
10 positive regulation of nitric-oxide synthase activity GO:0051000 9.54 GCH1 HIF1A
11 chondrocyte differentiation GO:0002062 9.54 BMP2 GDF5 SOX9
12 chondrocyte development GO:0002063 9.52 ACAN SOX9
13 positive regulation of cartilage development GO:0061036 9.51 BMP2 SOX9
14 epithelial to mesenchymal transition GO:0001837 9.5 BMP2 HIF1A SOX9
15 negative regulation of bone mineralization GO:0030502 9.49 HIF1A SOX9
16 endocardial cushion morphogenesis GO:0003203 9.48 BMP2 SOX9
17 positive regulation of ossification GO:0045778 9.46 BMP2 CALCA
18 negative regulation of ossification GO:0030279 9.43 CALCA HIF1A SOX9
19 response to pain GO:0048265 9.33 CALCA COMT GCH1
20 cartilage development GO:0051216 9.26 BMP2 GDF5 HIF1A SOX9
21 negative regulation of mesenchymal cell apoptotic process GO:2001054 8.8 GDF5 HIF1A SOX9

Molecular functions related to Degenerative Disc Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.92 BMP2 CALCA GDF5 NPY

Sources for Degenerative Disc Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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