MCID: DGN002
MIFTS: 32

Degenerative Myopia

Categories: Eye diseases

Aliases & Classifications for Degenerative Myopia

MalaCards integrated aliases for Degenerative Myopia:

Name: Degenerative Myopia 12 14
Myopia, Degenerative 41 69
Degenerative Progressive High Myopia 12
Progressive High Myopia 12
Progressive High Myopia 12
Pathological Myopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11829
ICD10 32 H44.2
ICD9CM 34 360.21
MeSH 41 D047728
UMLS 69 C0154778

Summaries for Degenerative Myopia

MalaCards based summary : Degenerative Myopia, also known as myopia, degenerative, is related to myopia and stickler syndrome, type i, nonsyndromic ocular. An important gene associated with Degenerative Myopia is ZNF644 (Zinc Finger Protein 644), and among its related pathways/superpathways are ECM proteoglycans and Cell adhesion_Plasmin signaling. The drugs Ranibizumab and Iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is behavior/neurological.

Related Diseases for Degenerative Myopia

Diseases related to Degenerative Myopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 myopia 28.4 CRYAA GJD2 LAMA1 LUM VEGFA ZNF644
2 stickler syndrome, type i, nonsyndromic ocular 10.9
3 choroiditis 10.2
4 retinitis 10.0
5 blood group, globoside system 9.9 CRYAA VEGFA
6 retinal vascular occlusion 9.9 CRYAA VEGFA
7 rubeosis iridis 9.8 CRYAA VEGFA
8 glaucoma, primary open angle 9.8
9 aging 9.8
10 macular degeneration, age-related, 1 9.8
11 open-angle glaucoma 9.8
12 chorioretinitis 9.8
13 degeneration of macula and posterior pole 9.8 CRYAA VEGFA
14 refractive error 9.7 CHRNG GJD2 ZNF644
15 lens disease 9.6 CRYAA VEGFA

Graphical network of the top 20 diseases related to Degenerative Myopia:



Diseases related to Degenerative Myopia

Symptoms & Phenotypes for Degenerative Myopia

MGI Mouse Phenotypes related to Degenerative Myopia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CHRNG GJD2 LAMA1 LUM NRN1 VEGFA

Drugs & Therapeutics for Degenerative Myopia

Drugs for Degenerative Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 347396-82-1 459903
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
4
Ofloxacin Approved Phase 4 82419-36-1 4583
5
Povidone Approved Phase 4 9003-39-8
6
Povidone-iodine Approved Phase 4 25655-41-8
7
Lactitol Investigational Phase 4 585-86-4 3871
8 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
9 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Ophthalmic Solutions Phase 4,Not Applicable
11 Tetrahydrozoline Phase 4,Not Applicable
12 cadexomer iodine Phase 4
13
Verteporfin Approved, Investigational Phase 3,Phase 1 129497-78-5
14 Dermatologic Agents Phase 3,Phase 1
15 Pharmaceutical Solutions Phase 3,Not Applicable
16 Photosensitizing Agents Phase 3,Phase 1
17 Combretastatin Investigational Phase 2 82855-09-2
18
Fosbretabulin Investigational Phase 2 222030-63-9 5351387
19 Antimitotic Agents Phase 2
20 Antineoplastic Agents, Phytogenic Phase 2
21
Bevacizumab Approved, Investigational Phase 1,Not Applicable 216974-75-3
22
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
23
Atropine Approved, Vet_approved Not Applicable 5908-99-6, 51-55-8 174174
24
Ephedrine Approved Not Applicable 299-42-3 9294
25
Ketorolac Approved Not Applicable 74103-06-3, 66635-83-4 3826
26
Pseudoephedrine Approved Not Applicable 90-82-4 7028
27 Anti-Inflammatory Agents Not Applicable
28 glucocorticoids Not Applicable
29 Hormone Antagonists Not Applicable
30 Hormones Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
32 Immunosuppressive Agents Not Applicable
33 triamcinolone acetonide Not Applicable
34 Triamcinolone diacetate Not Applicable
35 Triamcinolone hexacetonide Not Applicable
36 Adjuvants, Anesthesia Not Applicable
37 Analgesics Not Applicable
38 Analgesics, Non-Narcotic Not Applicable
39 Anesthetics Not Applicable
40 Anti-Arrhythmia Agents Not Applicable
41 Anti-Asthmatic Agents Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
43 Antirheumatic Agents Not Applicable
44 Autonomic Agents Not Applicable
45 Bronchodilator Agents Not Applicable
46 Cholinergic Agents Not Applicable
47 Cholinergic Antagonists Not Applicable
48 Cyclooxygenase Inhibitors Not Applicable
49 Ketorolac Tromethamine Not Applicable
50 Muscarinic Antagonists Not Applicable

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4 0.5mg intravitreal ranibizumab
2 A Randomized, Double-blind, Multicenter, Sham-controlled, Safety and Efficacy Study of Conbercept in Patients With mCNV Unknown status NCT01809223 Phase 3 conbercept, Fixed;conbercept, PRN
3 Efficacy and Safety of Ranibizumab in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia Completed NCT01217944 Phase 3 Ranibizumab;Verteporfin PDT;Sham Ranibizumab;Sham verteporfin PDT
4 A Study of the Criteria Establishing the Need for Re-treatment With Ranibizumab Upon Relapse in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia. Completed NCT02034006 Phase 3 Ranibizumab
5 VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV) Completed NCT01249664 Phase 3
6 Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum Unknown status NCT02623543 Phase 2
7 Ranibizumab for the Treatment of Choroidal Neovascularisation (CNV) Secondary to Pathological Myopia (PM): an Individualized Regimen Completed NCT01037348 Phase 2 ranibizumab 0.5mg
8 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
9 Safety and Efficacy Study of Combretastatin A4 Phosphate to Treat Patients With Choroidal Neovascularization Secondary to Pathologic Myopia Completed NCT01423149 Phase 2 Combretastatin A-4 Phosphate
10 Bevicizumab (Avastin) Infusion for Choroidal Neovascularization (CNV) Not Associated With Age-Related Macular Degeneration (AMD) Completed NCT00407719 Phase 1 Bevacizumab
11 The Efficacy and Safety of Periocular Acupoint Stimulation on Myopia Progression in Children Completed NCT02064660 Phase 1
12 Reduced-fluence Verteporfin Photodynamic Therapy Plus Ranibizumab for Choroidal Neovascularization in Pathologic Myopia Completed NCT01968486 Phase 1 PDT standard fluence, ranibizumab;PDT reduced fluence, ranibizumab;ranibizumab
13 Genomewide Screening of Pathological Myopia Unknown status NCT00155753
14 The Role of SNP of ECM and MMP on the Development of Pathological High Myopia Unknown status NCT00172952
15 Early Vitrectomy for Macular Tractional Maculopathy Unknown status NCT01121978 Not Applicable
16 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Not Applicable Optive
17 Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases Recruiting NCT03128463 Intravitreal injection of conbercept
18 The Relationship Between Structure and Visual Function in Myopia Foveoschisis Recruiting NCT02915133
19 Effectiveness of Orthokeratology in Myopia Control Recruiting NCT03465748 Not Applicable
20 Eye Drops Study for Myopia Control in Schoolchildren Recruiting NCT03402100 Not Applicable eye drops
21 Efficacy Study of Different Lens Treatments on Chinese Adolescent Myopia Recruiting NCT02001415 Not Applicable
22 Myopia Progression With a Novel Extended Depth of Focus Contact Lens Enrolling by invitation NCT03358862

Search NIH Clinical Center for Degenerative Myopia

Cochrane evidence based reviews: myopia, degenerative

Genetic Tests for Degenerative Myopia

Anatomical Context for Degenerative Myopia

MalaCards organs/tissues related to Degenerative Myopia:

38
Eye

Publications for Degenerative Myopia

Articles related to Degenerative Myopia:

(show all 21)
# Title Authors Year
1
Degenerative myopia: myopic macular schisis and the posterior pole buckle. ( 23190923 )
2013
2
Pathology of macular foveoschisis associated with degenerative myopia. ( 20814547 )
2010
3
Aqueous humor level of sCD44 in patients with degenerative myopia and primary open-angle glaucoma. ( 19895708 )
2009
4
Effect of peripapillary chorioretinal atrophy on GDx parametersin patients with degenerative myopia. ( 12427231 )
2002
5
Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and degenerative myopia. ( 11162982 )
2001
6
Choroidal and retinal blood flow changes in degenerative myopia. ( 8743218 )
1996
7
Photocoagulation scar expansion after laser therapy for choroidal neovascularization in degenerative myopia. ( 1708513 )
1990
8
Choroidal neovascularization in degenerative myopia: role of laser photocoagulation. ( 2448722 )
1987
9
Familial sinus node disease and degenerative myopia--a new hereditary syndrome? ( 3943873 )
1986
10
Natural history of choroidal neovascularization in degenerative myopia. ( 6084222 )
1984
11
The etiopathogenesis of degenerative myopia. ( 6229208 )
1983
12
Aetiopathogenesis of degenerative myopia. A hypothesis. ( 6216444 )
1982
13
Degenerative myopia. ( 4697188 )
1973
14
A simplified technique for surgical treatment of degenerative myopia. ( 5054236 )
1972
15
Scleral reinforcement in degenerative myopia. ( 5291554 )
1971
16
THE CONCEPT OF DEGENERATIVE MYOPIA. ( 14262010 )
1965
17
The glaucomatous disc in degenerative myopia. ( 5227179 )
1965
18
SURGICAL TREATMENT OF DEGENERATIVE MYOPIA. SCLERAL REINFORCEMENT. ( 14167191 )
1964
19
Surgical treatment of degenerative myopia. ( 5889605 )
1963
20
Retinal changes in degenerative myopia. ( 13900972 )
1962
21
Surgical treatment of degenerative myopia; the combined lamellar scleral resection with scleral reinforcement using donor eye. ( 13635801 )
1958

Variations for Degenerative Myopia

Expression for Degenerative Myopia

Search GEO for disease gene expression data for Degenerative Myopia.

Pathways for Degenerative Myopia

Pathways related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.91 LAMA1 LUM
2 10.65 LAMA1 VEGFA
3 10.04 LAMA1 VEGFA

GO Terms for Degenerative Myopia

Cellular components related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.8 LAMA1 LUM VEGFA

Biological processes related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 CRYAA GJD2 LUM

Molecular functions related to Degenerative Myopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 LAMA1 LUM

Sources for Degenerative Myopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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