MCID: DGN002
MIFTS: 30

Degenerative Myopia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Degenerative Myopia

MalaCards integrated aliases for Degenerative Myopia:

Name: Degenerative Myopia 12 14
Myopia, Degenerative 42 69
Degenerative Progressive High Myopia 12
Progressive High Myopia 12
Progressive High Myopia 12
Pathological Myopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11829
ICD10 33 H44.2
ICD9CM 35 360.21
MeSH 42 D047728
UMLS 69 C0154778

Summaries for Degenerative Myopia

MalaCards based summary : Degenerative Myopia, also known as myopia, degenerative, is related to stickler sydrome, type i, nonsyndromic ocular and myopia. An important gene associated with Degenerative Myopia is ZNF644 (Zinc Finger Protein 644), and among its related pathways/superpathways are ECM proteoglycans and Cell adhesion_Plasmin signaling. The drugs Ranibizumab and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is behavior/neurological.

Related Diseases for Degenerative Myopia

Diseases related to Degenerative Myopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
id Related Disease Score Top Affiliating Genes
1 stickler sydrome, type i, nonsyndromic ocular 10.8
2 myopia 10.4
3 choroiditis 10.1
4 conjugate gaze palsy 9.9 CRYAA VEGFA
5 retinitis 9.9
6 cryptosporidiosis 9.9 CRYAA VEGFA
7 anorectal stricture 9.9 CRYAA VEGFA
8 algoneurodystrophy 9.8 CRYAA VEGFA
9 chorioretinitis 9.7
10 open-angle glaucoma 9.7
11 accommodative esotropia 9.7 CHRNG GJD2 ZNF644
12 placental choriocarcinoma 9.6 CRYAA VEGFA
13 hypersensitivity vasculitis 9.4 GJD2 LUM VEGFA ZNF644
14 visual epilepsy 6.9 CHRNG CRYAA GJD2 LAMA1 LUM NRN1

Graphical network of the top 20 diseases related to Degenerative Myopia:



Diseases related to Degenerative Myopia

Symptoms & Phenotypes for Degenerative Myopia

MGI Mouse Phenotypes related to Degenerative Myopia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CHRNG GJD2 LAMA1 LUM NRN1 VEGFA

Drugs & Therapeutics for Degenerative Myopia

Drugs for Degenerative Myopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 347396-82-1 459903
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3
Ofloxacin Approved Phase 4 82419-36-1 4583
4
Povidone Approved Phase 4 9003-39-8
5 Povidone-iodine Approved Phase 4 25655-41-8
6
Iodine Investigational Phase 4 7553-56-2 807
7
Lactitol Investigational Phase 4 585-86-4 3871
8 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
9 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Ophthalmic Solutions Phase 4
11 Tetrahydrozoline Phase 4
12 cadexomer iodine Phase 4
13
Verteporfin Approved, Investigational Phase 3,Phase 1 129497-78-5
14
Bevacizumab Approved, Investigational Phase 3,Phase 1 216974-75-3
15 Dermatologic Agents Phase 3,Phase 1
16 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
17 Photosensitizing Agents Phase 3,Phase 1
18 Combretastatin Investigational Phase 2 82855-09-2
19
Fosbretabulin Investigational Phase 2 222030-63-9 5351387
20 Antimitotic Agents Phase 2
21 Antineoplastic Agents, Phytogenic Phase 2
22
Triamcinolone Approved, Vet_approved 124-94-7 31307
23
Menthol Approved 2216-51-5 16666
24 Anti-Inflammatory Agents
25 glucocorticoids
26 Hormone Antagonists
27 Hormones
28 Hormones, Hormone Substitutes, and Hormone Antagonists
29 Immunosuppressive Agents
30 triamcinolone acetonide
31 Triamcinolone diacetate
32 Triamcinolone hexacetonide

Interventional clinical trials:

(show all 28)

id Name Status NCT ID Phase Drugs
1 PreView PHP Preferential Hyperacuity Perimeter for the Detection of Choroidal Neovascularization Completed NCT00358345 Phase 4
2 Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization Recruiting NCT03042871 Phase 4 0.5mg intravitreal ranibizumab
3 A Randomized, Double-blind, Multicenter, Sham-controlled, Safety and Efficacy Study of Conbercept in Patients With mCNV Unknown status NCT01809223 Phase 3 conbercept, Fixed;conbercept, PRN
4 Efficacy and Safety of Ranibizumab in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia Completed NCT01217944 Phase 3 Ranibizumab;Verteporfin PDT;Sham Ranibizumab;Sham verteporfin PDT
5 A Study of the Criteria Establishing the Need for Re-treatment With Ranibizumab Upon Relapse in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia. Completed NCT02034006 Phase 3 Ranibizumab
6 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
7 VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV) Completed NCT01249664 Phase 3
8 Ranibizumab for the Treatment of Choroidal Neovascularisation (CNV) Secondary to Pathological Myopia (PM): an Individualized Regimen Completed NCT01037348 Phase 2 ranibizumab 0.5mg
9 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
10 Safety and Efficacy Study of Combretastatin A4 Phosphate to Treat Patients With Choroidal Neovascularization Secondary to Pathologic Myopia Completed NCT01423149 Phase 2 Combretastatin A-4 Phosphate
11 Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum Recruiting NCT02623543 Phase 2
12 Research With Retinal Cells Derived From Stem Cells for Myopic Macular Degeneration Withdrawn NCT02122159 Phase 1, Phase 2
13 Bevicizumab (Avastin) Infusion for Choroidal Neovascularization (CNV) Not Associated With Age-Related Macular Degeneration (AMD) Completed NCT00407719 Phase 1 Bevacizumab
14 The Efficacy and Safety of Periocular Acupoint Stimulation on Myopia Progression in Children Completed NCT02064660 Phase 1
15 Reduced-fluence Verteporfin Photodynamic Therapy Plus Ranibizumab for Choroidal Neovascularization in Pathologic Myopia Completed NCT01968486 Phase 1 PDT standard fluence, ranibizumab;PDT reduced fluence, ranibizumab;ranibizumab
16 Genomewide Screening of Pathological Myopia Unknown status NCT00155753
17 The Role of SNP of ECM and MMP on the Development of Pathological High Myopia Unknown status NCT00172952
18 Early Vitrectomy for Macular Tractional Maculopathy Unknown status NCT01121978
19 Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia. Completed NCT00347451
20 Relationships Between Macular Pigment Optical Density and Lacquer Cracks in High Myopic Patients. Completed NCT02205632
21 Macular Buckle With Three-armed Silicone Completed NCT02169635
22 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Optive
23 Observation of Treatment Patterns With Lucentis in Approved Indications Completed NCT02194803
24 Pharmacogenomic Study on Anti-VEGF Medicine in Treatment of Macular Neovascular Diseases Recruiting NCT03128463 Intravitreal injection of conbercept
25 The Relationship Between Structure and Visual Function in Myopia Foveoschisis Recruiting NCT02915133
26 Clinical Study Of Nearsightedness; TReatment With Orthokeratology Lenses Recruiting NCT03246464
27 Efficacy Study of Different Lens Treatments on Chinese Adolescent Myopia Recruiting NCT02001415
28 The Evolution of Visual Acuity Measured by Electronic Tablet / Computer of Exudative AMD Patients Recruiting NCT03214484

Search NIH Clinical Center for Degenerative Myopia

Cochrane evidence based reviews: myopia, degenerative

Genetic Tests for Degenerative Myopia

Anatomical Context for Degenerative Myopia

MalaCards organs/tissues related to Degenerative Myopia:

39
Eye

Publications for Degenerative Myopia

Articles related to Degenerative Myopia:

(show all 21)
id Title Authors Year
1
Degenerative myopia: myopic macular schisis and the posterior pole buckle. ( 23190923 )
2013
2
Pathology of macular foveoschisis associated with degenerative myopia. ( 20814547 )
2010
3
Aqueous humor level of sCD44 in patients with degenerative myopia and primary open-angle glaucoma. ( 19895708 )
2009
4
Effect of peripapillary chorioretinal atrophy on GDx parametersin patients with degenerative myopia. ( 12427231 )
2002
5
Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and degenerative myopia. ( 11162982 )
2001
6
Choroidal and retinal blood flow changes in degenerative myopia. ( 8743218 )
1996
7
Photocoagulation scar expansion after laser therapy for choroidal neovascularization in degenerative myopia. ( 1708513 )
1990
8
Choroidal neovascularization in degenerative myopia: role of laser photocoagulation. ( 2448722 )
1987
9
Familial sinus node disease and degenerative myopia--a new hereditary syndrome? ( 3943873 )
1986
10
Natural history of choroidal neovascularization in degenerative myopia. ( 6084222 )
1984
11
The etiopathogenesis of degenerative myopia. ( 6229208 )
1983
12
Aetiopathogenesis of degenerative myopia. A hypothesis. ( 6216444 )
1982
13
Degenerative myopia. ( 4697188 )
1973
14
A simplified technique for surgical treatment of degenerative myopia. ( 5054236 )
1972
15
Scleral reinforcement in degenerative myopia. ( 5291554 )
1971
16
THE CONCEPT OF DEGENERATIVE MYOPIA. ( 14262010 )
1965
17
The glaucomatous disc in degenerative myopia. ( 5227179 )
1965
18
SURGICAL TREATMENT OF DEGENERATIVE MYOPIA. SCLERAL REINFORCEMENT. ( 14167191 )
1964
19
Surgical treatment of degenerative myopia. ( 5889605 )
1963
20
Retinal changes in degenerative myopia. ( 13900972 )
1962
21
Surgical treatment of degenerative myopia; the combined lamellar scleral resection with scleral reinforcement using donor eye. ( 13635801 )
1958

Variations for Degenerative Myopia

Expression for Degenerative Myopia

Search GEO for disease gene expression data for Degenerative Myopia.

Pathways for Degenerative Myopia

Pathways related to Degenerative Myopia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.91 LAMA1 LUM
2 10.65 LAMA1 VEGFA
3 10.04 LAMA1 VEGFA

GO Terms for Degenerative Myopia

Cellular components related to Degenerative Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.8 LAMA1 LUM VEGFA

Biological processes related to Degenerative Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.8 CRYAA GJD2 LUM

Molecular functions related to Degenerative Myopia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 LAMA1 LUM

Sources for Degenerative Myopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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